Journal articles: 'Alinism'

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Methusela, Mishael Masanja, Mwita Imori Marko, and Juma Kaudunde Ismail. "Lifelong Agony Among People with Albinism (PWA): Tales From Lake Zone in Tanzania." Journal of Social and Political Sciences 3, no. 2 (2020): 329–37. https://doi.org/10.31014/aior.1991.03.02.172.

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A qualitative study conducted in the northern regions surrounding Lake Victoria in Tanzania, reveals that, People with Albinism (PWA) have been harshly treated for long. Mothers were required to terminate lives of their abnormally born infants (like albino infants). Besides lifelong challenges due to albinism condition, people searched for their body parts even after “being hidden” in unmarked graves after their deaths. Beliefs fuelling such ill-treatment on PWA are deep rooted and intertwined among peoples’ mind under influence of cultural beliefs existing for several decades. Proper approach should be designed for permanent solution of the long existed inhumane practices against People with Albinism.

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Kubakaddi, S. S., Kasala Suresha, and B. G. Mulimani. "Energy loss rate of two-dimensional electron gas in GaInAs/AlInAs, InSb/AlInSb and GaSb/AlGaAsSb heterostructures." Physica E: Low-dimensional Systems and Nanostructures 18, no. 4 (2003): 475–84. http://dx.doi.org/10.1016/s1386-9477(03)00227-3.

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Pasqualetti, Sara, Assunta Carnevale, Alberto Dolci, and Mauro Panteghini. "A step towards optimal efficiency of HbA_1c measurement as a first-line laboratory test: the TOP-HOLE (Towards OPtimal glycoHemOgLobin tEsting) project." Clinical Chemistry and Laboratory Medicine (CCLM) 60, no. 3 (2022): 441–50. http://dx.doi.org/10.1515/cclm-2021-1249.

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Abstract Objectives The TOP-HOLE (Towards OPtimal glycoHemOgLobin tEsting) project aimed to validate the HbA1c enzymatic method on the Abbott Alinity c platform and to implement the HbA1c testing process on the total laboratory automation (TLA) system of our institution. Methods Three different measuring systems were employed: Architect c4000 stand-alone (s-a), Alinity c s-a, and Alinity c TLA. Eight frozen whole blood samples, IFCC value-assigned, were used for checking trueness. A comparison study testing transferability of HbA1c results from Architect to Alinity was also performed. The alignment of Alinity TLA vs. s-a was verified and the measurement uncertainty (MU) estimated according to ISO 20914:2019. Turnaround time (TAT) and full time equivalent (FTE) were used as efficiency indicators. Results For HbA1c concentrations covering cut-offs adopted in clinical setting, the bias for both Architect and Alinity s-a was negligible. When compared with Architect, Alinity showed a mean positive bias of 0.54 mmol/mol, corresponding to a mean difference of 0.87%. A perfect alignment of Alinity TLA to the Alinity s-a was shown, and a MU of 1.58% was obtained, widely fulfilling the desirable 3.0% goal. After the full automation of HbA1c testing, 90% of results were released with a maximum TAT of 1 h, 0.30 FTE resource was also saved. Conclusions The traceability of Alinity HbA1c enzymatic assay to the IFCC reference system was correctly implemented. We successfully completed the integration of the HbA1c testing on our TLA system, without worsening the optimal analytical performance. The shift of HbA1c testing from s-a mode to TLA significantly decreased TAT.

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Patel, S., J. M. Petersen, and D. Jhala. "Comparison of Abbott COVID-19 testing Platforms for timely results- CMCVAMC experience." American Journal of Clinical Pathology 156, Supplement_1 (2021): S138—S139. http://dx.doi.org/10.1093/ajcp/aqab191.295.

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Abstract Introduction/Objective COVID-19 is a new disease, caused by the SARS-CoV-2 coronavirus capable of causing severe disease and death. The Alinity-m has a high throughput and random-access features that are not on the Abbott m2000, both of which had been validated and brought into clinical use for high throughput SARS-CoV-2 testing. The additional features of Alinity-m would be expected to improve turnaround time; however, there are no published reports in the English literature comparing the turnaround time between the Abbott m2000 and Alinity-m. Methods/Case Report A retrospective quality assurance search for all SARS-CoV-2 tests performed on the Abbott m2000 and Alinity-m (both Chicago IL) between February 1st 2021 to March 1st, 2021, to capture the turnaround time differences for the Abbott m2000 versus the Alinity-m for the month after the Alinity-m was brought into clinical service after validation. Results (if a Case Study enter NA) There was a total of 318 tests performed on the Abbott m2000 and 1329 tests performed on the Alinity-m during this time period. The average turnaround time on the Alinity was 6 hours, compared with 11 hours on the Abbott m2000. This difference was statistically significant by the t-test (p-value = &lt;0.01). Both the optimized throughput and random-access features of the Alinity-m contributed significantly to this improvement. The Alinity-m is capable of producing results within 115 minutes for the first specimen and then 3 minutes for each sequential specimen. On the other hand, the Abbott m2000 must be batched in limited 8-12 hour runs without random access capability. All the results were reported and communicated to the clinical teams, so the timely patient management can be administrated and surveillance of the same can be done in real time. Conclusion Alinity M has a significant advantage for a random access as well as improved TAT for detection of SARS-CoV-2, leading to prompt patient care and management.

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Kurdowski, W. "Bromide alinite." Cement and Concrete Research 17, no. 2 (1987): 361–64. http://dx.doi.org/10.1016/0008-8846(87)90119-0.

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Slim, Christiaan L., Brigitte A. Wevers, Martijn W. H. J. Demmers, et al. "Multicenter performance evaluation of the Abbott Alinity hq hematology analyzer." Clinical Chemistry and Laboratory Medicine (CCLM) 57, no. 12 (2019): 1988–98. http://dx.doi.org/10.1515/cclm-2019-0155.

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Abstract Background Alinity hq (Abbott) is a new high-throughput hematology analyzer that exclusively employs optical principles for detecting and enumerating blood cells. It reports 29 parameters, including a six-part white blood cell (WBC) differential. The aim of this multicenter study was to evaluate the analytical and clinical performance of the Alinity hq. Methods Complete blood count (CBC) results and morphological flagging were compared to that of CELL-DYN Sapphire (Abbott) and 2 × 200-cell manual differential results, on 1473 whole-blood samples from a well-defined patient population from three different clinical laboratories in the Netherlands. In addition, within-run and within-laboratory precision, linearity, limit of quantitation, carryover and sample stability were assessed. External quality assessment samples were also evaluated. Results Data analysis demonstrated strong concordance of Alinity hq results with those of CELL-DYN Sapphire for all CBC parameters, except for basophil granulocytes. Alinity hq WBC differential showed high level of agreement with manual differential results and exhibited a better agreement with manual basophil results than CELL-DYN Sapphire. The sensitivity of the Alinity hq Blast flag was 57.6%, equal to the 57.6% sensitivity of the CELL-DYN Sapphire’s Blast Alert. When considering samples with ≥5% blasts, the sensitivity of the Alinity hq Blast flag was 70.0%. Analytical performance of Alinity hq was shown to be consistent with state-of-the-art (SOTA) performance characteristics. Conclusions Alinity hq CBC measurands demonstrated good overall agreement with results obtained with CELL-DYN Sapphire, as well as manual WBC differential. The analytical and clinical performance characteristics of Alinity hq make it well suited for clinical laboratories.

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Guo, Xiao Lu, Hui Sheng Shi, and Jia Bao Huang. "Effects of Cement Additives on Alinite Cement-Based Materials from Municipal Solid Waste Incineration (MSWI) Fly Ash." Key Engineering Materials 727 (January 2017): 1046–53. http://dx.doi.org/10.4028/www.scientific.net/kem.727.1046.

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Municipal solid waste incineration (MSWI) fly ash was successfully used as a main raw material in sintering and preparing alinite cement clinker in laboratory. Based on this, this work focused on the effects of cement admixtures on the compressive strength and durability of the alinite cement-based materials. The optimum mix mass ratio was confirmed, i.e. the mass ratio of alinite cement clinker / gypsum / cement additives (MSWI fly ash, fly ash, or slag) was 80 % / 5 % / 15 %. The experimental results showed that addition of cement additives could improve resistance to sulfate attack of the prepared alinite cement-based materials. The resistance to carbonation and water permeability could be improved by adding different cement additives. The effectiveness is specimen AD3 (with 15 wt. % slag) > AB3 (with 15 wt. % MSWI fly ash) > AC3 (with 15 wt. % fly ash). However, addition of cement additives had negative effects on the dry shrinkage. Finally, with the hydration ages increasing, the content of soluble chloride ion from alinite cement specimen AB3 was decreased. It would be stable in long term. This work improves utilization of industrial solid wastes as cement additives in the prepared alinite cement from MSWI fly ash. It is beneficial for our understanding and application of alinite composite cement as construction and building materials.

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Goldstein, Emily, Laura Martinez-García, Martin Obermeier, et al. "Simultaneous identification of Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium, and Trichomonas vaginalis ‒ multicenter evaluation of the Alinity m STI assay." Journal of Laboratory Medicine 45, no. 4-5 (2021): 213–23. http://dx.doi.org/10.1515/labmed-2020-0136.

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Abstract Objectives Accurate and rapid diagnosis of sexually transmitted infections (STIs) is essential for timely administration of appropriate treatment and reducing the spread of the disease. We examined the performance of the new Alinity m STI assay, a qualitative real-time multiplex PCR test for simultaneous identification of Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Mycoplasma genitalium (MG), and Trichomonas vaginalis (TV) run on the fully automated Alinity m platform. Methods This international, multicenter study evaluated the accuracy, reproducibility, and clinical performance of the Alinity m STI assay compared to commonly used STI assays in a large series of patient samples encountered in clinical practice. Results The Alinity m STI assay identified accurately and precisely single and mixed pathogens from an analytical panel of specimens. The Alinity m STI assay demonstrated high overall agreement rates with comparator STI assays (99.6% for CT [n=2,127], 99.2% for NG [n=2,160], 97.1% for MG [n=491], and 99.4% for TV [n=313]). Conclusions The newly developed Alinity m STI assay accurately detects the 4 sexually transmitted target pathogens in various collection devices across clinically relevant specimen types, regardless of single or mixed infection status.

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Bohn, Mary Kathryn, Siobhan Wilson, Alexandra Hall, and Khosrow Adeli. "Pediatric reference interval verification for endocrine and fertility hormone assays on the Abbott Alinity system." Clinical Chemistry and Laboratory Medicine (CCLM) 59, no. 10 (2021): 1680–87. http://dx.doi.org/10.1515/cclm-2021-0337.

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Abstract Objectives The Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER) has developed an extensive database of reference intervals (RIs) for several biomarkers on various analytical systems. In this study, pediatric RIs were verified for key immunoassays on the Abbott Alinity system based on the analysis of healthy children samples and comparison to comprehensive RIs previously established for Abbott ARCHITECT assays. Methods Analytical performance of Alinity immunoassays was first assessed. Subsequently, 100 serum samples from healthy children recruited with informed consent were analyzed for 16 Alinity immunoassays. The percentage of test results falling within published CALIPER ARCHITECT reference and confidence limits was determined. If ≥ 90% of test results fell within the confidence limits, they were considered verified based on CLSI guidelines. If <90% of test results fell within the confidence limits, additional samples were analyzed and new Alinity RIs were established. Results Of the 16 immunoassays assessed, 13 met the criteria for verification with test results from ≥ 90% of healthy serum samples falling within the published ARCHITECT confidence limits. New CALIPER RIs were established for free thyroxine and prolactin on the Alinity system. Estradiol required special considerations in early life. Conclusions Our data demonstrate excellent concordance between ARCHITECT and Alinity immunoassays, as well as the robustness of previously established CALIPER RIs for most immunoassays, eliminating the need for de novo RI studies for most parameters. Availability of pediatric RIs for immunoassays on the Alinity system will assist clinical laboratories using this new platform and contribute to improved clinical decision-making.

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Toja-Camba, Francisco José, Enrique Bandín-Vilar, Gonzalo Hermelo-Vidal, et al. "Towards Precision Medicine in Clinical Practice: Alinity C vs. UHPLC-MS/MS in Plasma Aripiprazole Determination." Pharmaceutics 16, no. 1 (2024): 104. http://dx.doi.org/10.3390/pharmaceutics16010104.

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Therapeutic drug monitoring improves the benefit–risk balance of antipsychotic therapy. Ultra-high-performance liquid chromatography–tandem mass spectrometry (UHPLC-MS/MS) is considered the gold-standard method for measuring plasma drug concentrations; however, the Alinity C system has emerged as a promising alternative. This is the first study aimed at comparing UHPLC-MS/MS versus Alinity C in measuring plasma concentrations of aripiprazole and dehydroaripiprazole. A total of 86 plasma samples were analyzed. The active moiety of aripiprazole was measured in 60 samples using both systems and 26 samples were analyzed twice using Alinity C with an intermediate period of 6 months to assess its reproducibility. Spearman’s correlation revealed a good association between the two assays (rs = 0.96) and no significance differences were found by McNemar’s test when classifying samples between infra-, supra- and therapeutic ranges. Passing–Bablock regression showed a good correlation among methods (rs = 0.93) and a slope of 1.12 indicating a slight tendency of Alinity C to measure higher values than UHPLC-MS/MS. In addition, a good intra-method correlation across the two sequential analyses with Alinity C was obtained (rs = 0.99). Nonetheless, clinical decisions could be different in 15% of the cases depending on the chosen method. No differences were found in active moiety determination by Alinity C depending on the concentration of aripiprazole and dehydroaripiprazole of the samples.

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Burke, Jasper E., Thuy Hien T. Nguyen, Tanya Davis, et al. "Evaluation of the i-STAT Alinity v in a veterinary clinical setting." Journal of Veterinary Diagnostic Investigation 33, no. 4 (2021): 703–10. http://dx.doi.org/10.1177/10406387211019710.

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Many point-of-care (POC) analyzers are available for the measurement of electrolytes and acid-base status in animals. We assessed the precision of the i-STAT Alinity v, a recently introduced POC analyzer, and compared it to 2 commonly used and previously validated POC analyzers (i-STAT 1, Stat Profile pHOx Ultra). Precision was evaluated by performing multiple analyses of whole blood samples from healthy dogs, cats, and horses on multiple i-STAT Alinity v analyzers. For comparison between analyzers, whole blood samples from dogs and cats presented to the emergency room were run concurrently on all 3 POC instruments. Reported values were compared by species (dogs and cats only) using Pearson correlation, and all values from all species were analyzed together for the Bland–Altman analysis. Results suggested that the i-STAT Alinity v precision was very good, with median coefficients of variability <2.5% for all measured parameters (except the anion gap), with variable ranges of coefficients of variation. In addition, good-to-excellent correlation was observed between the i-STAT Alinity v and i-STAT 1, and between the i-STAT Alinity v and Stat Profile pHOx Ultra for all parameters in both cats and dogs, respectively. In this cohort, the i-STAT Alinity v had clinically acceptable bias compared to the currently marketed analyzers and can be used for monitoring measured analytes in cats and dogs, although serial measurements in a single animal should be performed on the same analyzer whenever possible.

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Aloisio, Elena, Erika Frusciante, Sara Pasqualetti, et al. "Traceability validation of six enzyme measurements on the Abbott Alinity c analytical system." Clinical Chemistry and Laboratory Medicine (CCLM) 58, no. 8 (2020): 1250–56. http://dx.doi.org/10.1515/cclm-2020-0015.

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AbstractBackgroundLaboratory professionals should independently verify the correct implementation of metrological traceability of commercial measuring systems and determine if their performance is fit for purpose. We evaluated the trueness, uncertainty of measurements, and transferability of six clinically important enzyme measurements (alanine aminotransferase [ALT], alkaline phosphatase [ALP], aspartate aminotransferase [AST], creatine kinase [CK], γ-glutamyltransferase [γGT], and lactate dehydrogenase [LDH]) performed on the Abbott Alinity c analytical system.MethodsTarget values and associated uncertainties were assigned to three pools for each enzyme by using the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) reference measurement procedures (RMPs) and the pools were then measured on the Alinity system. Bias estimation and regression studies were performed, and the uncertainty associated with Alinity measurements was also estimated, using analytical performance specifications (APS) derived from biological variability of measurands as goals. Finally, to validate the transferability of the obtained results, a comparison study between two Alinity systems located in Milan, Italy, and Bydgoszcz, Poland, was carried out.ResultsCorrect implementation of traceability to the IFCC RMPs and acceptable measurement uncertainty fulfilling desirable (ALP, AST, LDH) or optimal APS (ALT, CK, γGT) was verified for all evaluated enzymes. An optimal alignment between the two Alinity systems located in Milan and Bydgoszcz was also found for all enzyme measurements.ConclusionsWe confirmed that measurements of ALT, ALP, AST, CK, γGT, and LDH performed on the Alinity c analytical system are correctly standardized to the IFCC reference measurement systems and the system alignment is consistent between different platforms.

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Bohn, Mary Kathryn, Siobhan Wilson, Alexandra Hall, Youssef Massamiri, Ed Randell, and Khosrow Adeli. "Pediatric reference interval verification for common biochemical assays on the Abbott Alinity system." Clinical Chemistry and Laboratory Medicine (CCLM) 59, no. 9 (2021): 1554–62. http://dx.doi.org/10.1515/cclm-2021-0336.

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Abstract Objectives The quality of clinical laboratory service depends on quality laboratory operations and accurate test result interpretation based on reference intervals (RIs). As new analytical systems continue to be developed and improved, previously established RIs must be verified. The Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER) has established comprehensive RIs for many biomarkers on several analytical systems. Here, published CALIPER RIs for 28 chemistry assays on the Abbott ARCHITECT were assessed for verification on the newer Alinity system. Methods An analytical validation was first completed to assess assay performance. CALIPER serum samples (100) were analyzed for 28 chemistry assays on the Alinity system. The percentage of results falling within published pediatric ARCHITECT reference and confidence limits was determined for each analyte. Based on Clinical and Laboratory Standards Institute (CLSI) guidelines, if ≥90% of test results fell within confidence limits of ARCHITECT assay RIs, they were considered verified. Results Of the 28 assays assessed, 26 met the criteria for verification. Reference values for calcium and magnesium did not meet the criteria for verification with 87% and 35% falling within previously established ARCHITECT confidence limits, respectively. However, both assays could be verified using pediatric RIs provided in the Abbott Alinity package insert. Conclusions In this study, CALIPER ARCHITECT RIs were verified on the Alinity system for several chemistry assays. These data demonstrate excellent concordance for most assays between the Abbott ARCHITECT and Alinity systems and will assist in the implementation of the Alinity system in pediatric healthcare institutions.

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Gaisler, V. A., I. A. Derebezov, A. V. Gaisler, and D. V. Dmitriev. "Luminescence of InAs and AlInAs Single Quantum Dots." Siberian Journal of Physics 13, no. 4 (2018): 117–25. http://dx.doi.org/10.25205/2541-9447-2018-13-4-117-125.

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Aina, Leye, and Mike Mattingly. "Electron mobilities of AlInAs and AlInAs/InP heterostructures." Journal of Applied Physics 64, no. 10 (1988): 5253–55. http://dx.doi.org/10.1063/1.342413.

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Khengar, S. J., P. R. Parmar, and P. B. Thakor. "An ab initio Study of Structural, Electronic and Optical Properties of Janus AlInS₂ homo-bilayer." Journal of Physics: Conference Series 2518, no. 1 (2023): 012012. http://dx.doi.org/10.1088/1742-6596/2518/1/012012.

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Abstract By using the first principle calculations, the structural, electronic and optical properties of Janus AlInS2 Bilayer have been calculated. The Janus AlInS2 shows a honey-comb stable structure with semiconducting behaviour having indirect bandgap. The bilayer is found to be energetically favourable. The density of states (DOS) is calculated for Janus AlInS2 Bilayer. It shows absorptions in the visible and ultraviolet regions where prominent peaks of absorption coefficient is found in ultraviolet region of order 105 cm−1. The Janus AlInS2 Bilayer has a high static refractive Index. From the results, it is concluded that Janus AlInS2 Bilayer has a potential application in optoelectronic devices such as coating material to increase reflectivity.

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Zulkafli, Zefarina, Noor Haslina, and Shafini Mohamed Yusoff. "6-Parts Haematology Parameters Evaluation Using Abbott Alinity H." Asian Journal of Medicine and Biomedicine 8, no. 1 (2024): 15–19. http://dx.doi.org/10.37231/ajmb.2024.8.1.651.

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Nowadays, there are variety of automated hematology analyzers available in the market. However, the new product of diagnostic equipment should be evaluated and validated to ensure their capability. Thorough process of testing on all new hematology analyzers must be performed to certify that reliable result will be released and for patient safety. This study was carried out to evaluate automated hematology analyzers; Abbott Alinity H, in the Hospital Universiti Sains Malaysia setting. Blood samples send for complete blood count were selected randomly (n = 50) from healthy subjects and those who have different blood disorders. Blood specimens and quality control materials were analysed on the Abbott Alinity H to evaluate the precision. For correlation, the Sysmex XN-1000 was used as the comparative method. The study showed very good correlation between Abbott Alinity H and Sysmex, XN-1000 in the parameters such as white blood cell (WBC), red blood cell (RBC), hemoglobin (HGB), mean cell volume (MCV), platelet (PLT), neutrophil (NEU), lymphocyte (LYM), monocyte (MONO), eosinophil (EOS), and basophil (BASO). For the precision, all the parameters are performed well within allowable limits of performance for Abbott Alinity H. In conclusion, the Abbott Alinity H demonstrated an acceptable performance in term of precision and the analyzer was equivalent with the Sysmex XN-1000.

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Patel, S., and D. Jhala. "Validation and Implementation of molecular RT-PCR COVID-19 Testing Platforms." American Journal of Clinical Pathology 156, Supplement_1 (2021): S139. http://dx.doi.org/10.1093/ajcp/aqab191.297.

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Abstract Introduction/Objective COVID-19 is caused by the SARS-CoV-2 coronavirus that has led to a worldwide pandemic with an unprecedented need for fast and accurate testing under FDA Emergency Use Authorizations (EUA). Despite the promise of the Alinity-m as an upgrade from the Abbott m2000 for optimization of high throughput testing and random access for laboratory workflow, validation studies comparing Alinity-m to already used Abbott m2000 are sparse in the literature, particularly for the veteran population. Methods/Case Report The validation study for the Alinity m (Chicago IL) was performed in three parts 1) Method to method sample/patient correlation study, 2) precision study (at 250 virus copies/mL, 500 virus copies/mL and 1000 virus copies/mL versus 4 negatives), and 3) verification and confirmation of the accuracy of the assay at the lower limit of detection (LOD). For the validation study. The patient specimens were used side by side for both assays. The results from the Abbott m2000 (Chicago IL), which was already established in our lab, were used as a reference for validation. Results (if a Case Study enter NA) The validation with a method to method correlation included 157 valid specimens from which concordant results were obtained for all 157 specimens on both the Alinity-m and Abbott m2000. The precision or reproducibility of the Alinity-m was verified at all concentrations. The limit of detection verification on diluted samples determined the limit of detection to be 20 virus copies/mL (&gt;95% of dilution samples agreed with positive results at this level), which confirmed even below the manufacturer provided LOD of 100 virus copies/mL. Conclusion Alinity m was validated for clinical use with study demonstrating that it is 1) equivalent in the method to method correlation, precision, and LOD determination. 2)The validation of Alinity m, holds great promise with its optimized throughput for testing of large numbers of specimens with less technician handling and random access, is a valuable addition to the literature of test validations under the FDA EUA. 3)The validation of tests under the FDA EUA is unprecedented and provides an important way to improve patient care during this extraordinary pandemic.

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Jugwanth, Sarika, Maemu P. Gededzha, Nakampe Mampeule, et al. "Performance of the Abbott SARS-CoV-2 IgG serological assay in South African 2 patients." PLOS ONE 17, no. 2 (2022): e0262442. http://dx.doi.org/10.1371/journal.pone.0262442.

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In late December 2019, pneumonia cases of unknown origin were reported in Wuhan, China. This virus was named SARS-CoV2 and the clinical syndrome was named coronavirus disease 19 (COVID-19). South Africa, despite strict and early lockdown has the highest infection rate in Africa. A key component of South Africa’s response to SARSCoV2 was the rapid scale-up of diagnostic testing. The Abbott SARS-CoV2 assay detects IgG antibodies against the Nucleocapsid (N) protein of the SARS-CoV2 virus. This study undertook to validate and evaluate performance criteria of the Abbott assay and to establish whether this assay would show clinical utility in our population. Positive patients (n = 391) and negative controls (n = 139) were included. The Architect-i and Alinity-i systems were analyzers that were used to perform the SARS-CoV-2 IgG assay. In-house ELISA was incorporated into the study as a confirmatory serology test. A total of number of 530 participants was tested, 87% were symptomatic with infection and 13% were asymptomatic. When compared to RT-qPCR, the sensitivity of Architect and Alinity SARS-CoV2 assays was 69.5% and 64.8%, respectively. Specificity for Architect and Alinity assays was 95% and 90.3%, respectively. The Abbott assay was also compared to in house ELISA assay, with sensitivity for the Architect and Alinity assays of 94.7% and 92.5%, respectively. Specificity for Abbott Alinity assays was 91.7% higher than Abbott Architect 88.1%. Based on the current findings testing of IgG after 14 days is recommended in South Africa and supports other studies performed around the world.

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Ermakov, A. I., N. N. Kotova, T. N. Vinogradova, and D. E. Kireev. "Evaluation of the use of additional capabilities of immunochemiluminescent analysis for determining the duration of infection with human immunodeficiency virus." Journal Infectology 16, no. 4 (2024): 105–11. http://dx.doi.org/10.22625/2072-6732-2024-16-3-105-111.

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Early assessment of HIV incidence is an important public health tool for understanding the state of the epidemic in a particular area, identifying high-risk groups, and assessing the effectiveness of HIV prevention interventions.Objective. To assess the possibility of using the positivity rate (S/CO) in the HIV Ag/Ab immunoassay on the Alinity i analytical platform to determine the duration of infection during HIV screening.Materials and methods. The study included 316 HIV-infected patients with different infection durations. Immunochemical analysis was performed on an Alinity i automatic analyzer (Abbott Laboratories, USA) using the Alinity i HIV Ag/Ab Reagent Kit (Abbott Laboratories, Germany) in accordance with the manufacturer’s instructions.Results. Statistical analysis of 316 blood samples from HIV-infected patients at different stages of infection demonstrated the reactivity of the Alinity i HIV Ag/Ab test result and a dynamic increase in the positivity ratio during the first six months after the onset of the disease. Based on the data obtained, a threshold value (≤294 conventional units) was obtained for the positivity ratio, which allowed for a clear distinction between HIV-positive patients with a recent (<6 months) period of infection. At the same time, the sensitivity and specificity indicators for detecting recent infection in the CMIA analysis were 79,0% and 63,2%, respectively.Conclusion. The additional usage of the positivity ratio in the Alinity i HIV Ag/Ab CMIA analysis meets the acceptability criteria for assessing the duration of HIV infection and can be a useful tool for analyzing the stage of the epidemic in a particular territory.

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Gaisler, A. V., I. A. Derebezov, V. A. Gaisler, et al. "AlInAs quantum dots." JETP Letters 105, no. 2 (2017): 103–9. http://dx.doi.org/10.1134/s0021364017020096.

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Lebedev, D. V., A. M. Mintairov, M. M. Kulagina, et al. "Lasing of InP/AlInAs quantum dots in AlInAs microdisk cavity." Journal of Physics: Conference Series 690 (February 2016): 012023. http://dx.doi.org/10.1088/1742-6596/690/1/012023.

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Aina, Leye, Mike Mattingly, Ayub Fathimulla, Eric A. Martin, Tom Loughran, and Lisa Stecker. "OMVPE growth of AlInAs and device quality AlInAs-based heterostructures." Journal of Crystal Growth 93, no. 1-4 (1988): 911–18. http://dx.doi.org/10.1016/0022-0248(88)90639-2.

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Stratton, Hayley S., Kimberly D. Ange-van Heugten, and Larry J. Minter. "Comparison of Hematocrit and Biochemical Analytes among Two Point-of-Care Analyzers (EPOC and i-STAT Alinity v) and a Veterinary Diagnostic Laboratory in the African Savanna Elephant (Loxodonta africana) and the Southern White Rhinoceros (Ceratotherium simum simum)." Journal of Zoological and Botanical Gardens 3, no. 4 (2022): 653–64. http://dx.doi.org/10.3390/jzbg3040048.

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This study compared hematocrit measured with the EPOC and i-STAT Alinity v point-of-care analyzers and manual measurement of packed cell volume in managed African savanna elephants (Loxodonta africana) and southern white rhinoceros (Ceratotherium simum simum). Biochemical analytes were also measured with the EPOC, i-STAT Alinity v, and a veterinary diagnostic laboratory in the same animals. Analytes assessed included blood urea nitrogen, chloride, creatinine, glucose, ionized calcium, potassium, and sodium. There were no differences for hematocrit values for African savanna elephants or southern white rhinoceros (p ≤ 0.05). In African savanna elephants, there were no differences between the EPOC and i-STAT Alinity v analyzers for any measured analytes except ionized calcium. When compared to a veterinary diagnostic laboratory, there were differences for a majority of the biochemical analytes measured on the EPOC and i-STAT Alinity v analyzers in African savanna elephants. In southern white rhinoceros, there were differences for a majority of analytes among all three analyzers. While differences existed among the portable analyzers and a veterinary diagnostic laboratory for biochemical analytes in both species, these numerically small differences are unlikely to be clinically significant. For routine health care of African savanna elephants and southern white rhinoceros, these point-of-care analyzers may be a useful alternative to commercial analyzers for the parameters evaluated.

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Loubna Yacoubi, Zainab Kajeiou, Sabah Mokhtari, et al. "Verification of the analytical performance of the serum gamma-glutamyl transferase assay on the Abbott Alinity ci®: Experience of the biochemistry laboratory of the Mohammed VI university hospital of Oujda." World Journal of Biology Pharmacy and Health Sciences 15, no. 2 (2023): 098–103. http://dx.doi.org/10.30574/wjbphs.2023.15.2.0349.

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Introduction: As part of our study, we set out to evaluate the analytical performance of the gamma-glutamyl transferase (GGT) assay using an Abbott kit on the Alinity ci® automated system in the biochemistry laboratory of the CHU Mohammed VI in Oujda. Materials and methods: This study assessed the repeatability and reproducibility of Alinity ci® and compared the results obtained by the Alinity ci® and Architect ci-8200® automated systems. Results: The results obtained met the acceptability criteria recommended by the supplier and the Valtec protocol of the Société Française de Biologie Clinique (SFBC), demonstrating overall satisfaction with the study. The Alinity ci® automated system demonstrated the analytical performance required for accurate and reliable determination of GGT levels. Discussion: Validation of an analytical method is an essential step in guaranteeing that the result obtained is as close as possible to the reference value of a sample. Several standards and technical guides set out requirements for the performance criteria of an analytical method, notably NF EN ISO 15 189. Conclusion: the verification study of the GGT assay method produced satisfactory results, providing a high level of reliability for analysis results from the central laboratory of the CHU Mohammed VI d'Ouja. This work forms an essential basis for developing an accreditation procedure, which is part of the quality approach to which our laboratory is committed.

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Stratton, Hayley S., Heugten Kimberly D. Ange-van, and Larry J. Minter. "Comparison of Hematocrit and Biochemical Analytes among Two Point-of-Care Analyzers (EPOC and i-STAT Alinity v) and a Veterinary Diagnostic Laboratory in the African Savanna Elephant (Loxodonta africana) and the Southern White Rhinoceros (Ceratotherium simum simum)." Journal of Zoological and Botanical Gardens 3, no. 4 (2022): 653–64. https://doi.org/10.5281/zenodo.13536948.

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(Uploaded by Plazi for the Bat Literature Project) This study compared hematocrit measured with the EPOC and i-STAT Alinity v point-of-care analyzers and manual measurement of packed cell volume in managed African savanna elephants (Loxodonta africana) and southern white rhinoceros (Ceratotherium simum simum). Biochemical analytes were also measured with the EPOC, i-STAT Alinity v, and a veterinary diagnostic laboratory in the same animals. Analytes assessed included blood urea nitrogen, chloride, creatinine, glucose, ionized calcium, potassium, and sodium. There were no differences for hematocrit values for African savanna elephants or southern white rhinoceros (p ≤ 0.05). In African savanna elephants, there were no differences between the EPOC and i-STAT Alinity v analyzers for any measured analytes except ionized calcium. When compared to a veterinary diagnostic laboratory, there were differences for a majority of the biochemical analytes measured on the EPOC and i-STAT Alinity v analyzers in African savanna elephants. In southern white rhinoceros, there were differences for a majority of analytes among all three analyzers. While differences existed among the portable analyzers and a veterinary diagnostic laboratory for biochemical analytes in both species, these numerically small differences are unlikely to be clinically significant. For routine health care of African savanna elephants and southern white rhinoceros, these point-of-care analyzers may be a useful alternative to commercial analyzers for the parameters evaluated.

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Stratton, Hayley S., Heugten Kimberly D. Ange-van, and Larry J. Minter. "Comparison of Hematocrit and Biochemical Analytes among Two Point-of-Care Analyzers (EPOC and i-STAT Alinity v) and a Veterinary Diagnostic Laboratory in the African Savanna Elephant (Loxodonta africana) and the Southern White Rhinoceros (Ceratotherium simum simum)." Journal of Zoological and Botanical Gardens 3, no. 4 (2022): 653–64. https://doi.org/10.5281/zenodo.13536948.

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(Uploaded by Plazi for the Bat Literature Project) This study compared hematocrit measured with the EPOC and i-STAT Alinity v point-of-care analyzers and manual measurement of packed cell volume in managed African savanna elephants (Loxodonta africana) and southern white rhinoceros (Ceratotherium simum simum). Biochemical analytes were also measured with the EPOC, i-STAT Alinity v, and a veterinary diagnostic laboratory in the same animals. Analytes assessed included blood urea nitrogen, chloride, creatinine, glucose, ionized calcium, potassium, and sodium. There were no differences for hematocrit values for African savanna elephants or southern white rhinoceros (p ≤ 0.05). In African savanna elephants, there were no differences between the EPOC and i-STAT Alinity v analyzers for any measured analytes except ionized calcium. When compared to a veterinary diagnostic laboratory, there were differences for a majority of the biochemical analytes measured on the EPOC and i-STAT Alinity v analyzers in African savanna elephants. In southern white rhinoceros, there were differences for a majority of analytes among all three analyzers. While differences existed among the portable analyzers and a veterinary diagnostic laboratory for biochemical analytes in both species, these numerically small differences are unlikely to be clinically significant. For routine health care of African savanna elephants and southern white rhinoceros, these point-of-care analyzers may be a useful alternative to commercial analyzers for the parameters evaluated.

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Aninkevičius, V., A. Matulionis, and I. Matulioniene. "Hot-phonon lifetime in a modulation-doped AlInAs/GaInAs/AlInAs/InP." Semiconductor Science and Technology 20, no. 2 (2004): 109–14. http://dx.doi.org/10.1088/0268-1242/20/2/001.

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Brown, A. S., U. K. Mishra, C. S. Chou, et al. "AlInAs-GaInAs HEMTs utilizing low-temperature AlInAs buffers grown by MBE." IEEE Electron Device Letters 10, no. 12 (1989): 565–67. http://dx.doi.org/10.1109/55.43141.

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Kurdowski, Wieslaw, and Urszula Moryc. "Once more about bromide alinite." Cement and Concrete Research 19, no. 4 (1989): 657–61. http://dx.doi.org/10.1016/0008-8846(89)90018-5.

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Toja-Camba, Francisco José, Gonzalo Hermelo-Vidal, Carolina Feitosa-Medeiros, et al. "Head-to-Head Comparison of UHPLC-MS/MS and Alinity C for Plasma Analysis of Risperidone and Paliperidone." Pharmaceuticals 17, no. 11 (2024): 1446. http://dx.doi.org/10.3390/ph17111446.

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Background and objectives: Risperidone, a second-generation antipsychotic widely used in the treatment of schizophrenia, requires therapeutic drug monitoring due to its high interindividual variability. UHPLC-MS/MS is considered the gold standard for pharmacokinetic studies owing to its superior sensitivity and specificity, although it involves time-consuming manual sample preparation. In contrast, the Alinity C system, fully automated, simplifies sample processing, but only measures the active moiety (risperidone plus paliperidone). The aim of this study is to compare the performance of UHPLC-MS/MS and the Alinity C system for the determination of risperidone and paliperidone concentrations in plasma. Methods: A total of 115 plasma samples of 115 patients, 92 and 23 under risperidone and paliperidone long-acting treatment, respectively, were analyzed using both methods. Results: A strong correlation for the active moiety (risperidone plus 9-OH-Risperidone) (rs = 0.95) was observed. However, Bland–Altman analysis revealed a mean bias of 0.996 ng/mL, indicating that the Alinity C system slightly overestimates concentrations compared to UHPLC-MS/MS. While there was substantial agreement between methods (κ = 0.72), discrepancies were observed in 16.3% of cases, which could impact clinical decision-making. When analyzing paliperidone separately, the agreement was lower (κ = 0.63), with greater variability observed. Conclusions: These findings suggest that, while the Alinity C system is suitable for routine therapeutic monitoring, UHPLC-MS/MS remains the preferred method in clinical scenarios requiring higher precision, particularly for patients with concentrations near therapeutic thresholds.

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Sabah Mokhtari, Loubna Yacoubi, Imane Naji, et al. "Verification of the analytical performance of the serum phosphorus assay on the Abbott Alinity ci®: Experience of the central laboratory Mohammed VI University Hospital of Oujda." World Journal of Biology Pharmacy and Health Sciences 16, no. 1 (2023): 233–38. http://dx.doi.org/10.30574/wjbphs.2023.16.1.0401.

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Introduction: In our study, we aimed to evaluate the analytical performance of the serum phosphorus determination method using an Abbott kit on the Alinity c automaton at the biochemistry laboratory of Mohammed VI University Hospital of Oujda. Materials and methods: We evaluated the performance of the kit using flexible scope A and conducted a thorough performance study on the Alinity c automaton. This study encompassed assessments of repeatability, reproducibility and comparisons of results obtained from two Alinity c automatons. Results: The obtained results met the acceptability criteria recommended by the supplier and the French Society of Clinical Biology(Société Française de Biologie Clinique SFBC) Valtec protocol, indicating overall satisfaction with the study. The Alinity c automaton exhibited the necessary analytical performance to ensure accurate and dependable determination of phosphorus levels. Discussion: Ensuring accurate and reliable results, the verification of the serum phosphorus determination method in the medical laboratory is crucial. This process entails implementing quality control measures, calibration, and comparing with established reference methods. It guarantees that the laboratory's phosphorus testing method is precise, accurate, and compliant with industry standards, thereby upholding the quality of patient care. Conclusion: The verification study of the serum phosphorus determination method yielded satisfactory results, providing high reliability to the test results from the central laboratory at Mohammed VI University Hospital of Oujda. This verification study serves as a strong foundation in the accreditation process, ensuring the accuracy and quality of laboratory testing, and enhancing the overall reliability of patient care

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Loubna, Yacoubi, Kajeiou Zainab, Mokhtari Sabah, et al. "Verification of the analytical performance of the serum gamma-glutamyl transferase assay on the Abbott Alinity ci®: Experience of the biochemistry laboratory of the Mohammed VI university hospital of Oujda." World Journal of Biology Pharmacy and Health Sciences 15, no. 2 (2023): 098–103. https://doi.org/10.5281/zenodo.10677048.

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Introduction: As part of our study, we set out to evaluate the analytical performance of the gamma-glutamyl transferase (GGT) assay using an Abbott kit on the Alinity ci® automated system in the biochemistry laboratory of the CHU Mohammed VI in Oujda. Materials and methods: This study assessed the repeatability and reproducibility of Alinity ci® and compared the results obtained by the Alinity ci® and Architect ci-8200® automated systems. Results: The results obtained met the acceptability criteria recommended by the supplier and the Valtec protocol of the Société Française de Biologie Clinique (SFBC), demonstrating overall satisfaction with the study. The Alinity ci® automated system demonstrated the analytical performance required for accurate and reliable determination of GGT levels. Discussion: Validation of an analytical method is an essential step in guaranteeing that the result obtained is as close as possible to the reference value of a sample. Several standards and technical guides set out requirements for the performance criteria of an analytical method, notably NF EN ISO 15 189. Conclusion: the verification study of the GGT assay method produced satisfactory results, providing a high level of reliability for analysis results from the central laboratory of the CHU Mohammed VI d'Ouja. This work forms an essential basis for developing an accreditation procedure, which is part of the quality approach to which our laboratory is committed.

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Moniuszko-Malinowska, Anna, Wojciech Jelski, Justyna Dunaj, et al. "Serology in COVID-19: Comparison of Two Methods." International Journal of Environmental Research and Public Health 18, no. 12 (2021): 6497. http://dx.doi.org/10.3390/ijerph18126497.

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Background: The aim of our study was to examine the performance of two assays in detecting SARS-CoV-2 antibodies. Methods: A total of 127 COVID-19 disease contacts from the Infectious Diseases Department were included. Two serological tests were used: SARS-CoV-2 IgG CMIA on the Alinity system (Abbott) and LIAISON® SARS-CoV-2 S1/S2 IgG CLIA (DiaSorin). Results: The assays exhibited a 96.85% (123/127 patients) test result agreement. In two cases, the positive results obtained by SARS-CoV-2 IgG CMIA on the Alinity system (Abbott) were negative based on the LIAISON® SARS-CoV-2 S1/S2 IgG CLIA (DiaSorin) test, and in two cases, negative results from the LIAISON® SARS-CoV-2 S1/S2 IgG CLIA (DiaSorin) test were positive with the SARS-CoV-2 IgG CMIA on the Alinity system (Abbott). Conclusions: Based on the results of our study, we conclude that in population medicine, the assessments of anti-SARS-CoV-2 antibodies after exposure to SARS-CoV-2 virus based on spike protein or nucleocapsid protein show comparable effectiveness.

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Aina, O., M. Serio, M. Mattingly, and E. Hempfling. "Novel AlInAs/InP HEMT." Electronics Letters 26, no. 10 (1990): 651–52. http://dx.doi.org/10.1049/el:19900426.

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Huang, Jie, Ming Li, and Kei-May Lau. "Normally-off metamorphic AlInAs/AlInAs HEMTs on Si substrates grown by MOCVD." Chinese Physics B 24, no. 7 (2015): 078102. http://dx.doi.org/10.1088/1674-1056/24/7/078102.

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Abraham, P., M. A. Garcia Perez, T. Benyattou, G. Guillot, M. Sacilotti, and X. Letartre. "Temperature dependence of AlInAs band gap energy and AlInAs/InP band offsets." Materials Science and Technology 14, no. 12 (1998): 1291–94. http://dx.doi.org/10.1179/mst.1998.14.12.1291.

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Pereira, Gabriela, Marcus Wilcox Hemais, and Mariana Betine. "DISTANCIAMENTO ENTRE ACADÊMICOS E EMPREENDEDORES EM CONTEXTOS DE BAIXA RENDA." Revista Economia & Gestão 20, no. 56 (2020): 25–44. http://dx.doi.org/10.5752/p.1984-6606.2020v20n56p25-44.

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O presente estudo analisa como empreendedores em contextos de baixa renda operam seus negócios, para verificar se suas práticas se alinham/distanciam de ensinamentos do meio acadêmico. Foram realizadas entrevistas em profundidade com nove professores universitários e oito empreendedores desse contexto, para comparar seus relatos a respeito de quais teorias, conceitos e modelo de marketing seriam importantes para o sucesso de empreendedores. Os achados mostram que, em geral, práticas dos empreendedores pouco se alinham com ensinamentos acadêmicos quanto a análise ambiental, pesquisa de marketing e segmentação e posicionamento de mercado, porém se aproximam quando adotadas ações do composto de marketing.

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Sabah, Mokhtari, Yacoubi Loubna, Naji Imane, et al. "Verification of the analytical performance of the serum phosphorus assay on the Abbott Alinity ci®: Experience of the central laboratory Mohammed VI University Hospital of Oujda." World Journal of Biology Pharmacy and Health Sciences 16, no. 1 (2023): 233–38. https://doi.org/10.5281/zenodo.10791239.

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Introduction: In our study, we aimed to evaluate the analytical performance of the serum phosphorus determination method using an Abbott kit on the Alinity c automaton at the biochemistry laboratory of Mohammed VI University Hospital of Oujda. Materials and methods: We evaluated the performance of the kit using flexible scope A and conducted a thorough performance study on the Alinity c automaton. This study encompassed assessments of repeatability, reproducibility and comparisons of results obtained from two Alinity c automatons. Results: The obtained results met the acceptability criteria recommended by the supplier and the French Society of Clinical Biology(Société Française de Biologie Clinique SFBC) Valtec protocol, indicating overall satisfaction with the study. The Alinity c automaton exhibited the necessary analytical performance to ensure accurate and dependable determination of phosphorus levels. Discussion: Ensuring accurate and reliable results, the verification of the serum phosphorus determination method in the medical laboratory is crucial. This process entails implementing quality control measures, calibration, and comparing with established reference methods. It guarantees that the laboratory's phosphorus testing method is precise, accurate, and compliant with industry standards, thereby upholding the quality of patient care. Conclusion: The verification study of the serum phosphorus determination method yielded satisfactory results, providing high reliability to the test results from the central laboratory at Mohammed VI University Hospital of Oujda. This verification study serves as a strong foundation in the accreditation process, ensuring the accuracy and quality of laboratory testing, and enhancing the overall reliability of patient care

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Fajriyah, Mira. "Refraksi dan Alinasi Pengangkatan Hakim Konstitusi." Jurnal Konstitusi 12, no. 2 (2016): 237. http://dx.doi.org/10.31078/jk1223.

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The Justice appointment of The Constitutional Court is an entry point of the independence and impartiality of The Constitutional Court in Indonesia. There is some refraction on the mechanism of the Justice appointment of The Constitutional Court either in the juridical case also in the socio-juridical case. In the juridical case, there is a substantive regulation flaw as be found in UUD N RI 1945, UU KK dan UU MK. In the socio-juridical case, there is three discourse points to change the mechanism of the Justice appointment of The Constitutional Court. Those discourse points consist of the context of requirement, the ultimate right enforcement of DPR, Presiden and Mahkamah Agung in the Justice appointment of The Constitutional Court which dealing the democratic principle, and the last is about the ideal composition of The Constitutional Court’s Justice based on their political background. Those juridical and socio-juridical cases have to guiding back to the characteristic of The Constitutional Court which will produce the alignment of The Justice appointment of The Constitutional Court. The concept is a juridical alignment that changing the regulation of mechanism of the Justice appointment of The Constitutional Court to fulfill the law hierarchy system and also to accommodate the socio-juridical case substantively and democratically.

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BİLİR-, Abdullah. "MELEKLERİN MASUMİYETİ İNANCININ TEFSİRLERDE ELE ALINIŞI." Journal of Social Sciences 51, no. 51 (2021): 513–30. http://dx.doi.org/10.29228/sobider.49510.

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Zaidah, Nuning. "HISTORIFIKASI, ALINASI PADA TEATER EPIK BRECHT DAN SENI DRAMA TRADISI KETHOPRAK." Jurnal IKADBUDI 5, no. 12 (2017). http://dx.doi.org/10.21831/ikadbudi.v5i12.12310.

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Historifikasi, alinasi pada Teater Epik Bertolt Brecht mempunyai kemiripan dengan pertunjukan seni drama tradisi Kethoprak. Alinasi dalam naskah karya Brecht muncul dari rangkaian pemikirannya, yaitu Historifikasi-Alinasi-Epik. Historifikasi adalah usaha Brecht untuk menempatkan aktor seolah-olah memainkan sebuah adegan sejarah. Alinasi adalah usaha untuk menggambarkan sebuah peristiwa ke dalam bentuk baru yang bertujuan untuk mencegah penonton menjadi katarsis, sedangkan Epik adalah diambil dari kata epos atau cerita kepahlawanan. Ketiga hal tersebut, alinasi menjadi unsur paling sering dibahas dalam konteks pembicaraan tentang teater Epik. Untuk mendapatkan alinasi, Brecht tidak menciptakan metode khusus pelatihan aktor dalam mencapainya, tetapi alinasi tersebut melekat dalam naskah yang ditulisnya. Alinasi didapatkan dari cara menganalisis struktur naskahnya. Historifikasi-Alinasi-Epik juga terdapat pada struktur naskah lakon-lakon pertunjukan seni drama tradisi Kethoprak berupa dialog, mood dan spectacle.Kata kunci: historifikasi, alinasi, Teater Epik Brecht, Kethoprak.

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Sasaki, M., X. Wang, D. Toolsie, G. Cloherty, and D. Lucic. "B-189 Alinity m You-Create Lab-Developed Test for hepatitis delta virus." Clinical Chemistry 70, Supplement_1 (2024). http://dx.doi.org/10.1093/clinchem/hvae106.549.

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Abstract Background Lab developed tests (LDTs) play an important role in the realm of infectious diseases. Current molecular diagnostic platforms offer fully automated high-throughput performance capable of running LDTs. The Alinity m platform enables users to run LDTs concurrently with other FDA cleared or approved IVD assays with its Alinity m You-Create feature. Here, we investigated the performance of an LDT assay targeting hepatitis delta virus (HDV) using commercially available PCR reagents. Methods Alinity m You-Create LDT for HDV was evaluated using Applied Biosystems TaqMan Fast Virus 1-Step Multiplex Master Mix, No ROX, (ThermoFisher, Cat: 5555532). Sample extraction utilized Alinity m Sample Prep Kit 2. Alinity m You-Create HDV LDT analytical performance for sensitivity, linearity and precision was assessed using panels prepared by diluting the HDV 1st WHO international standard in negative plasma. Alinity m You-Create HDV LDT clinical performance was assessed by comparing 45 HDV positive samples previously tested on the m2000 HDV LDT. Assay specificity was assessed testing 97 HDV negative, HBV and/or HCV positive (by serology or nucleic acid amplification test). Results Alinity m You-Create HDV LDT had 100% detection as low as 2.5 IU/mL with SD ≤0.25 Log IU/mL for panels that were ≥2.5 IU/mL. Coefficient of correlation between Alinity m You-Create HDV LDT and m2000 HDV LDT was 0.969 and the mean bias was -0.16 Log IU/mL. All HDV negative specimens were undetected by Alinity m You-Create HDV LDT. Conclusions This study demonstrated successful implementation of an LDT for HDV on the Alinity m platform using the Alinity m You-Create feature using commercially available PCR reagents. The Alinity m You-Create feature for HDV has not been approved by FDA for use in the detection or diagnosis for HDV and its safety and effectiveness has not been established.

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Costa, Diego S., Marcel S. B. Quintana, Beatriz Grinsztejn, Valdiléa G. Veloso, and Simone C. C. Silva. "Evaluation of the analytical and clinical performance of the Abbott Alinity m instrument for the quantification of HIV-1 RNA plasma viral load in a reference laboratory in Rio de Janeiro, Brazil." American Journal of Clinical Pathology, July 13, 2024. http://dx.doi.org/10.1093/ajcp/aqae076.

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Abstract Objectives We sought to evaluate the analytical performance of the Alinity m system (Abbott Molecular) and to compare the clinical performance of HIV-1 assays on the Alinity m and m2000 RealTime platforms (Abbott Molecular). Methods The sensitivity, precision, and accuracy of the Alinity m instrument were determined using a panel of standard samples (n = 46). The carryover effect was assessed by analyzing HIV-negative clinical samples (n = 20). Clinical performance of the Alinity m and m2000 RealTime platforms was compared using surplus HIV-positive patient plasma samples (n = 39). Results The Alinity m HIV-1 assay demonstrated 100% sensitivity, a high precision (coefficient of variation (s/x̄) × 100 ≤1.5% [SD ≤ 0.05] logarithm to base 10 [log10] copies/mL), and partial accuracy over the quantification range. Analysis of clinical samples suggested that the Alinity m HIV-1 assay does not cause carryover effect and produced a mean bias of 0.209 log10 copies/mL (95% CI, 0.153-0.265) compared with the m2000 RealTime System. Conclusions The Alinity m instrument’s performance correlated to that of the m2000 RealTime platform and showed excellent sensitivity, precision, and accuracy, despite producing overquantification not clinically relevant for disease management. Furthermore, use of the Alinity m platform can reduce turnaround time.

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Lima, Amorce, Dominic Uy, Joshua Kostera, and Suzane Silbert. "Comparative Clinical Evaluation of the Alinity m STI Multiplex PCR Assay for Diagnosis and Surveillance of Chlamydia trachomatis, Neisseria gonorrhea, Trichomonas vaginalis, and Mycoplasma genitalium." Sexually Transmitted Diseases, March 4, 2024. http://dx.doi.org/10.1097/olq.0000000000001964.

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Abstract Background Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) are routinely tested and reported; however, Trichomonas vaginalis (TV) is the most common STI in the US and the prevalence of Mycoplasma genitalium (MG) infections is likely higher than estimated. We examined the clinical performance of the Alinity m STI assay for detection and surveillance of CT/NG/TV/MG in urine specimens from patients at a large academic medical center. Methods Urine specimen from 198 patients were tested in this evaluation. Alinity m STI and Aptima Combo 2 CT/NG and TV assay (Panther System) results were compared, with discrepant results run on the cobas 6800 CT/NG, TV/MG assays. Analyzer turnaround times (TAT), time from loading the specimen on the analyzer to results reporting, were determined for Alinity m and Panther systems. Results Overall percent agreement of the Alinity m in comparison with the Aptima and cobas assays for CT, NG, TV, and MG were respectively: 99.5% (97.2, 99.9%), 99.5% (97.2, 99.9%), 98.4% (95.5, 99.5%), and 86.4% (66.7, 95.3). There were 5 discrepant samples (CT = 1, NG = 1, TV = 3) between the Alinity m and the Aptima assays, and 3 MG discrepant samples between the Alinity m STI and cobas 6800. Two of the five Aptima and Alinity m discrepant samples were resolved as they yielded similar results on both Alinity m and cobas 6800. TV and MG infections comprised 54% of the positive samples and were more often asymptomatic than CT and NG infections. Analyzer TAT was 3 hours 25 minutes for the Aptima CT/NG, 3 hours 25 minutes for Aptima TV, and 1 hour 55 minutes for Alinity m STI assay. Conclusions The Alinity m STI assay allows for fast and simultaneous detection of the four major STI pathogens, which can facilitate surveillance and provide accurate results to help clinicians diagnose for initiation of appropriate treatment.

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"Abbott Alinity." Biomedical Safety & Standards 52, no. 12 (2022): 92. http://dx.doi.org/10.1097/01.bmsas.0000834844.67114.86.

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Oprea, Oana Roxana, Elena-Cristina Preda, Bogdana Dorcioman, Hannelore Doris Bucur, and Minodora Dobreanu. "Hematology instruments don’t speak the same language: a comparison study between flagging messages of sysmex XN-1000 and alinity H." Journal of Laboratory Medicine, October 15, 2024. http://dx.doi.org/10.1515/labmed-2024-0046.

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Abstract Objectives While manual review is the gold standard, automated hematology analyzers are increasingly used. This study assessed the efficiency of white blood cell (WBC)-related flagging messages from the Sysmex XN-1000 and Alinity hq analyzers compared to peripheral blood smear (PBS) findings and evaluated their inter-platform agreement. Methods K3EDTA blood samples from hospitalized patients were analyzed using the Sysmex XN-1000. Samples triggering a morphology flag were reanalyzed on the Alinity hq, with PBS reviewed per CLSI protocol H20-A2-2007. Results Of 5530 samples, 196 had morphology-related flags requiring PBS review. Sysmex flagged 144 samples with leukocyte-related messages; Alinity flagged 120. The positive predictive value (PPV) for the Left Shift flag was 100 % for Sysmex and 77.5 % for Alinity; for Immature Granulocytes, it was 19.4 % for Sysmex and 94.6 % for Alinity. The Blast Flag’s PPVs were 9.3 % for Sysmex and 17.9 % for Alinity. Left Shift specificities were high (>94 %), but sensitivities varied. Sysmex showed 100 % sensitivity for the Blast flag but moderate specificity (53 %), while Alinity performed well (77–82 %). Agreement between platforms ranged from poor to good. Conclusions Tailored SOPs are crucial for optimizing laboratory workflow based on different flagging performances. Understanding each analyzer’s strengths and limitations improves interpretation and workflow management.

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Obermeier, Martin, Monia Pacenti, Robert Ehret, et al. "Improved molecular laboratory productivity by consolidation of testing on the new random-access analyzer Alinity m." LaboratoriumsMedizin, November 9, 2020. http://dx.doi.org/10.1515/labmed-2020-0102.

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AbstractObjectivesAutomated molecular analyzers have accelerated diagnosis, allowing earlier intervention and better patient follow-up. A recently developed completely automated molecular analyzer, Alinity™ m (Abbott), offers consolidated, continuous, and random-access testing that may improve molecular laboratory workflow.MethodsAn international, multicenter study compared laboratory workflow metrics across various routine analyzers and Alinity m utilizing assays for human immunodeficiency virus type 1 (HIV-1), hepatitis C virus (HCV), hepatitis B virus (HBV), high-risk human papillomavirus (HR HPV), and sexually transmitted infection (STI) (Chlamydia trachomatis [CT]/Neisseria gonorrhoeae [NG]/Trichomonas vaginalis [TV]/Mycoplasma genitalium [MG]). Three turnaround times (TATs) were assessed: total TAT (sample arrival to result), sample onboard TAT (sample loading and test starting to result), and processing TAT (sample aspiration to result).ResultsTotal TAT was reduced from days with routine analyzers to hours with Alinity m, independent of requested assays. Sample onboard TATs for standard workflow using routine analyzers ranged from 7 to 32.5 h compared to 2.75–6 h for Alinity m. The mean sample onboard TAT for STAT samples on Alinity m was 2.36 h (±0.19 h). Processing TATs for Alinity m were independent of the combination of assays, with 100% of results reported within 117 min.ConclusionsThe consolidated, continuous, random-access workflow of Alinity m reduces TATs across various assays and is expected to improve both laboratory operational efficiency and patient care.

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Lee, Miae, Eliseo Albert, Els Wessels, et al. "Multicenter performance evaluation of the Alinity m CMV assay for quantifying cytomegalovirus DNA in plasma samples." Journal of Clinical Microbiology, September 20, 2023. http://dx.doi.org/10.1128/jcm.00415-23.

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ABSTRACT Monitoring of cytomegalovirus (CMV) viral load is critical for informing treatment decisions in order to prevent the severe health consequences of CMV infection or reactivation of latent CMV in immunocompromised individuals. This first field evaluation examined the analytical and clinical performance of the Alinity m CMV assay. Analytical performance was assessed with a commercially available six-member panel, while the clinical performance evaluation compared the Alinity m CMV assay to the RealTi m e CMV assay and a laboratory-developed test (LDT) as the test of record at three large hospital-based clinical laboratories. Precision of the Alinity m CMV assay was demonstrated with total standard deviation (SD) between 0.08 and 0.28 Log IU/mL. A total of 457 plasma specimens were tested on the Alinity m CMV assay and compared to the test of record at each site ( n = 304 with RealTi m e CMV and n = 153 with LDT CMV). The Alinity m CMV assay had excellent correlation (correlation coefficient r ≥0.942) in comparison to the RealTi m e CMV or LDT CMV assays. The mean observed bias ranged from −0.03 to 0.34 Log IU/mL. Median onboard turnaround time of Alinity m CMV was less than 3 h. When the CMV assay is run on the Alinity m system, it has the capacity to shorten time to result and, therefore, to therapy.

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Goldstein, D. Yitzchak, Mark M. Sasaki, Momka Narlieva, et al. "Performance evaluation of the high-throughput quantitative Alinity m Epstein-Barr virus assay." Microbiology Spectrum, November 15, 2024. http://dx.doi.org/10.1128/spectrum.01507-24.

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ABSTRACT Molecular testing for Epstein-Barr virus (EBV) infection is a cornerstone of care to prevent adverse outcomes in immunocompromised patients, including transplant recipients. We evaluated the analytical and clinical performance of the quantitative Alinity m EBV assay for plasma sample testing on the fully automated Alinity m platform. Assay lower limit of detection and precision were determined using commercially available panels in plasma. Alinity m EBV detected 100% of panels at 1.3 Log IU/mL, and precision ranged from 1.9% to 5.2% coefficients of variance (SD ≤ 0.14 Log IU/mL). Remnant-de-identified specimens initially tested with the Eurofins Viracor EBV Laboratory Developed Test (LDT) ( n = 357), ELITech EBV LDT ( n = 113), University of Washington (UW) LDT ( n = 151), or Roche cobas EBV assay ( n = 148) were subsequently tested with the Alinity m EBV assay. Comparison of the Alinity m EBV assay and Eurofins Viracor EBV assay demonstrated a correlation coefficient of 0.762 and mean bias of −0.48 Log IU/mL, comparison of the Alinity m EBV assay with UW LDT demonstrated a correlation coefficient of 0.970 and mean bias of −0.24 Log IU/mL, and comparison of the Alinity m EBV assay with cobas EBV demonstrated a correlation coefficient of 0.964 and mean bias of 0.35 Log IU/mL. The Alinity m EBV assay demonstrated high precision across the analytical measurement range and produced comparable results to the EBV test of record assays. These findings support the utility of the fully automated Alinity m EBV assay in transplant patient management. IMPORTANCE Epstein-Barr virus (EBV) infection and reactivation are associated with increased risk for post-transplant lymphoproliferative disorders (PTLD) in transplant recipients with the development of PTLD occurring predominantly within a year of transplant. Quantitative PCR for EBV is used to monitor the viral load of EBV with a negative result as a good negative predictor of PTLD. Nucleic acid amplification tests (NAATs) with high sensitivity and specificity are available on fully automated high-throughput instruments to provide accurate quantitation and improve test result turn-around time. This study evaluates the analytical and clinical performance of one such NAAT, the Alinity m EBV assay.

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Journal articles on the topic 'Alinism'

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