Relevant bibliographies by topics / Aliphatic compounds – Toxicology

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Academic literature on the topic 'Aliphatic compounds – Toxicology'

Author: Grafiati
Published: 4 June 2021
Last updated: 9 February 2022

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Journal articles on the topic "Aliphatic compounds – Toxicology"

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Coggins, Christopher R. E., Ann M. Jerome, Jeffery S. Edmiston, and Michael J. Oldham. "A comprehensive evaluation of the toxicology of cigarette ingredients: aliphatic carbonyl compounds." Inhalation Toxicology 23, sup1 (June 2011): 102–18. http://dx.doi.org/10.3109/08958378.2010.545842.

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2

Luo, Yu-Syuan, Kyle C. Ferguson, Ivan Rusyn, and Weihsueh A. Chiu. "In Vitro Bioavailability of the Hydrocarbon Fractions of Dimethyl Sulfoxide Extracts of Petroleum Substances." Toxicological Sciences 174, no. 2 (February 10, 2020): 168–77. http://dx.doi.org/10.1093/toxsci/kfaa007.

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Abstract Determining the in vitro bioavailable concentration is a critical, yet unmet need to refine in vitro-to-in vivo extrapolation for unknown or variable composition, complex reaction product or biological material (UVCB) substances. UVCBs such as petroleum substances are commonly subjected to dimethyl sulfoxide (DMSO) extraction in order to retrieve the bioactive polycyclic aromatic compound (PAC) portion for in vitro testing. In addition to DMSO extraction, protein binding in cell culture media and dilution can all influence in vitro bioavailable concentrations of aliphatic and aromatic compounds in petroleum substances. However, these in vitro factors have not been fully characterized. In this study, we aimed to fill in these data gaps by characterizing the effects of these processes using both a defined mixture of analytical standards containing aliphatic and aromatic hydrocarbons, as well as 4 refined petroleum products as prototypical examples of UVCBs. Each substance was extracted with DMSO, and the protein binding in cell culture media was measured by using solid-phase microextraction. Semiquantitative analysis for aliphatic and aromatic compounds was achieved via gas chromatography-mass spectrometry. Our results showed that DMSO selectively extracted PACs from test substances, and that chemical profiles of PACs across molecular classes remained consistent after extraction. With respect to protein binding, chemical profiles were retained at a lower dilution (higher concentration), but a greater dilution factor (ie, lower concentration) resulted in higher protein binding in cell medium, which in turn altered the ultimate chemical profile of bioavailable PACs. Overall, this case study demonstrates that extraction procedures, protein binding in cell culture media, and dilution factors prior to in vitro testing can all contribute to determining the final bioavailable concentrations of bioactive constituents of UVCBs in vitro. Thus, in vitro-to-in vivo extrapolation for UVCBs may require greater attention to the concentration-dependent and compound-specific differences in recovery and bioavailability.
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Coggins, Christopher R. E., Kimberly Frost-Pineda, Donna C. Smith, and Michael J. Oldham. "A comprehensive evaluation of the toxicology of cigarette ingredients: aromatic and aliphatic alcohol compounds." Inhalation Toxicology 23, sup1 (June 2011): 141–56. http://dx.doi.org/10.3109/08958378.2010.551552.

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4

Abarca-Vargas, Rodolfo, and Vera L. Petricevich. "Bougainvillea Genus: A Review on Phytochemistry, Pharmacology, and Toxicology." Evidence-Based Complementary and Alternative Medicine 2018 (June 24, 2018): 1–17. http://dx.doi.org/10.1155/2018/9070927.

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This review discusses the current knowledge of the phytochemistry and in vitro and in vivo evaluations carried out using the extracts and, where appropriate, the main active components isolated from the genus Bougainvillea. Out of 18 species, most phytochemical, pharmacological, and toxicological studies focused on four species with different cultivars and one hybrid. Some plants are used for the treatment of various health disorders. Numerous phytochemical investigations of plants in this genus confirm the presence of aliphatic hydrocarbons, fatty acids, fatty alcohols, volatile compounds, phenolic compounds, peltogynoids, flavonoids, phytosterols, terpenes, carbohydrates, and betalains. Various studies have confirmed that these extracts or active substances that were isolated from the genus Bougainvillea have multiple pharmacological activities. Some species of Bougainvillea have emerged as sources of traditional medicine in human health. More studies of the phytochemical, pharmacological, and toxicological properties and their mechanisms of action, safety, and efficacy in all Bougainvillea species, cultivars, and hybrids are advisable for future research.
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5

Kotowska, Urszula, and Valery Isidorov. "Partition coefficients of ketones, phenols, aliphatic and aromatic acids, and esters in n-hexane/nitromethane." Open Chemistry 9, no. 5 (October 1, 2011): 813–24. http://dx.doi.org/10.2478/s11532-011-0060-4.

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AbstractLiquid-liquid partition is used in sample preparation and in countercurrent and liquid-liquid chromatographic separations. Partition coefficients are widely used in toxicology, environmental, and analytical chemistry. The K hn determination procedure for the n-hexane/nitromethane system was optimized and partition coefficients for 99 ketones, esters and trimethylsilyl derivatives of phenols, aliphatic and aromatic acids were determined. For 130 compounds, K hn values were predicted using mathematical relationships between K hn and other physicochemical and structural parameters.
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Janssen, Dick B., Jan R. van der Ploeg, and Frens Pries. "Genetic Adaptation of Bacteria to Halogenated Aliphatic Compounds." Environmental Health Perspectives 103 (June 1995): 29. http://dx.doi.org/10.2307/3432474.

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Janssen, D. B., J. R. van der Ploeg, and F. Pries. "Genetic adaptation of bacteria to halogenated aliphatic compounds." Environmental Health Perspectives 103, suppl 5 (June 1995): 29–32. http://dx.doi.org/10.1289/ehp.95103s429.

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8

McKee, Richard H., and Russell White. "The Mammalian Toxicological Hazards of Petroleum-Derived Substances." International Journal of Toxicology 33, no. 1_suppl (December 18, 2013): 4S—16S. http://dx.doi.org/10.1177/1091581813514024.

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Petroleum-derived substances are complex and composed of aliphatic (normal-, iso-, and cycloparaffins), olefinic, and/or aromatic constituents. Approximately 400 of these complex substances were evaluated as part of the US Environmental Protection Agency voluntary High Production Volume (HPV) Challenge program. The substances were separated into 13 groups (categories), and all available data were assessed. Toxicology testing was conducted as necessary to fully address the end points encompassed by the HPV initiative. In a broad sense, volatile hydrocarbons may cause acute central nervous system effects, and those that are liquids at room temperature pose aspiration hazards if taken into the lungs as liquids and may also cause skin irritation. Higher boiling substances may contain polycyclic aromatic constituents (PACs) that can be mutagenic and carcinogenic and may also cause developmental effects. Substances containing PACs can also cause target organ and developmental effects. The effects of aliphatic constituents include liver enlargement and/or renal effects in male rats via an α-2u-globulin-mediated process and, in some cases, small but statistically significant reductions in hematological parameters. Crude oils may contain other constituents, particularly sulfur- and nitrogen-containing compounds, which are removed during refining. Aside from these more generic considerations, some specific petroleum substances may contain unusually toxic constituents including benzene, 1,3-butadiene, and/or n-hexane, which should also be taken into account if present at toxicologically relevant levels.
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Hu, Qing-yuan, and Can Wang. "Interaction of gaseous aromatic and aliphatic compounds in thermophilic biofilters." Journal of Hazardous Materials 300 (December 2015): 210–17. http://dx.doi.org/10.1016/j.jhazmat.2015.07.005.

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10

Rorije, Emiel, Lennart Eriksson, Hans Verboom, Henk J. M. Verhaar, Joop L. M. Hermens, and Willie J. G. M. Peijnenburg. "Predicting reductive transformation rates of halogenated aliphatic compounds using different QSAR approaches." Environmental Science and Pollution Research 4, no. 1 (March 1997): 47–54. http://dx.doi.org/10.1007/bf02986265.

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Dissertations / Theses on the topic "Aliphatic compounds – Toxicology"

1

Fawcett, Kimberly A. "Effects of chlorinated aliphatic hydrocarbon degradation on the metabolic enzymes in Nitrosomonas europaea." Thesis, 1999. http://hdl.handle.net/1957/33654.

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The toxic effects of degrading the chlorinated hydrocarbons trichloroethylene (TCE), chloroform (CF) and cis-1,2-dichloroethylene (cis-1,2-DCE) were studied in the bacterium Nitrosomonas europaea. N europaea is an ammonia-oxidizing bacterium that obtains all of its energy from the oxidation of ammonia to nitrite. This metabolic process involves two enzymes, ammonia monooxygenase (AMO) and hydroxylamine oxidoreductase (HAO). AMO has a broad substrate range and is also capable of oxidizing TCE, CF, and cis-1,2-DCE. Effects of degrading these chlorinated compounds on both AMO and HAO were studied. Cells were inactivated with known inhibitors of both AMO (light) and HAO (hydrogen peroxide) to provide comparison studies. Oxidation of the three chlorinated hydrocarbons did not always result in similar toxic effects to the cells. Whole cell studies indicated that oxidation of TCE and CF resulted in a loss of both NH������- and N���H���- dependent 0��� uptake rates, while in vitro studies indicated that at lower concentrations of both TCE (���0.05 mM) and CF (���0.10 mM) neither AMO or HAO appear to be the primary sites of inactivation. The oxidation of cis-1,2-DCE appeared to specifically inactivate AMO both in in vivo and in vitro assays. N europaea cells were also pretreated with the AMO inhibitor acetylene and incubated with the chlorinated hydrocarbons. Results of both whole cell 0��� uptake rates and the in vitro HAO assay confirms the hypothesis that the chlorinated hydrocarbons must be turned over in order to produce a toxic effect in N. europaea cells.
Graduation date: 1999
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Books on the topic "Aliphatic compounds – Toxicology"

1

Fawcett, Kimberly A. Effects of chlorinated aliphatic hydrocarbon degradation on the metabolic enzymes in Nitrosomonas europaea. 1999.

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