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Academic literature on the topic 'Alkaloid'

Author: Grafiati

Published: 4 June 2021

Last updated: 11 September 2023

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Journal articles on the topic "Alkaloid"

1

Han, Sunkyu, Sangbin Jeon, and Joonoh Park. "Syntheses of Dimeric Securinega Alkaloids." Synlett 28, no. 18 (August 22, 2017): 2353–59. http://dx.doi.org/10.1055/s-0036-1590864.

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The isolation of flueggenines A and B by Yue and co-workers in 2006 has triggered a burst of isolation reports of dimeric and oligomeric securinega alkaloid natural products. The compelling molecular structures of these compounds with various modes of connection between monomeric securinega units have posed intriguing challenges to the synthetic organic community. Herein, we have categorized high-order securinega alkaloids based on their biosynthetic mode of dimerization or oligomerization. We then have compiled all reported syntheses of dimeric securinega alkaloids based on our classification.1 Introduction2 Categorization of High-Order Securinega Alkaloid Natural Products3 Syntheses of Type I Dimeric Securinega Alkaloids4 Syntheses of Type II Dimeric Securinega Alkaloids5 Synthesis of Type III Dimeric Securinega Alkaloid6 Conclusion

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Věžník, František, Eva Táborská, Hana Bochořáková, František Tureček, Vladimír Hanuš, and Jiří Slavík. "Alkaloids of Papaver nudicaule SUBSP. xanthopetalum (TRAUTV.) FEDDE and P. nudicaule SUBSP. album (REGEL) FEDDE from the section Scapiflora REICHB." Collection of Czechoslovak Chemical Communications 52, no. 6 (1987): 1634–40. http://dx.doi.org/10.1135/cccc19871634.

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The alkaloidal composition in the two title taxa differs only quantitatively. Both contain amurine as the main alkaloid. P. nudicaule ssp. xanthopetalum contains muramine, protopine and alkaloid PN1 (probably identical with (±)-nudaurine (Ia)) as dominant alkaloids; further were isolated amurensine, epialpinine, cryptopine, mecambridine and alpinigenine. Allocryptopine, papaverrubines A, B, D and G, palmatine and coptisine were detected chromatographically. The quaternary alkaloid fraction afforded cis-N-methylstylopinium hydroxide (as the iodide II) which was isolated for the first time from P. nudicaule. In P. nudicaule ssp. album the alkaloid PN1, epialpinine, amurensine and muramine represented the dominant alkaloids, accompanied with mecambridine, protopine, cryptopine, allocryptopine and alpinigenine. Among the quaternary alkaloids N-methylstylopinium hydroxide was found.

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El-Shazly, A., A. M. Ateya, L. Witte, and M. Wink. "Quinolizidine Alkaloid Profiles of Retama raetam, R. sphaerocarpa and R. monosperma." Zeitschrift für Naturforschung C 51, no. 5-6 (June 1, 1996): 301–8. http://dx.doi.org/10.1515/znc-1996-5-607.

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Abstract About 28 quinolizidine alkaloids and the dipiperidine alkaloids am modendrine, dehydroammodendrine and N -formylammodendrine were identified in the alkaloidal extracts of Retama raetam, Retama sphaerocarpa and Retama monosperma by capillary GLC and GLCMS. Alkaloid profiles of the three Retama species with a Mediterranean distribution are more similar than alkaloid patterns of different organs of the same plant. Whereas sparteine and retamine are the major components of stems, lupanine, retam ine, N-methylcytisine and cytisine dominate in flowers and pods, and cytisine in seeds indicating a high degree of organ specificity of alkaloid storage.

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Wink, M., and L. Witte. "Quinolizidine Alkaloids as Nitrogen Source for Lupin Seedlings and Cell Cultures." Zeitschrift für Naturforschung C 40, no. 11-12 (October 1, 1985): 767–75. http://dx.doi.org/10.1515/znc-1985-11-1204.

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Abstract The alkaloid patterns during germination and seedling development of Lupinus polyphyllus, L. angustifolius, L. albus, L. pubescens, Cytisus scoparius, Baptisia australis, Spartium junceum and Laburnum anagyroides were studied by capillary glc and EI-MS and CI-MS. The alkaloid contents were relatively high in the seeds and decreased by 20-100% during germination and the early developmental stages. The plants with fully developed leaves were able to synthesize new alkaloids. The decrease of alkaloid concentrations during germination was interpreted in terms of alkaloid turnover and use of the alkaloidal nitrogen for seedling development. The ability of plants to rely on the alkaloidal nitrogen as a nitrogen source could also be shown in lupin cell cultures which could survive and even grow on media which contained sparteine as the sole nitrogen source.

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El-Shazly, Assem. "Pyrrolizidine Alkaloid Profiles of Some Senecio Species from Egypt." Zeitschrift für Naturforschung C 57, no. 5-6 (June 1, 2002): 429–33. http://dx.doi.org/10.1515/znc-2002-5-604.

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Alkaloid profiles of two Egyptian Senecio species (Senecio aegyptius var. discoideus and S. desfontainei) in addition to a cultivated species (S. cineraria) were studied using capillary GLC and GLC-mass spectrometry with respect to pyrrolizidine alkaloids (PAs). Four alkaloids were identified in S. aegyptius var. discoideus, 8 in S. desfontainei and 13 in S. cineraria. Some of these alkaloids have not been reported from these plants. The alkaloidal pattern of different plant organs (flowers, leaves, stem, root) were also investigated. Senecionine has been found to be a one of the major alkaloid in all studied species, it was isolated and its structure was elucidated by 1H- and 13C-NMR.

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Slavík, Jiří, and Leonora Slavíková. "Alkaloids of Meconopsis cambrica (L.) VIG. and M. robusta HOOK. f. et THOMS." Collection of Czechoslovak Chemical Communications 61, no. 12 (1996): 1815–22. http://dx.doi.org/10.1135/cccc19961815.

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Additional alkaloids (+)-roemerine (3b), (+)-corytuberine (3d), (-)-N-methylmecambridinium and alkaloid MC 2 (the last two as iodides) were isolated as minor alkaloidal components from Meconopsis cambrica (L.) VIG. (Papaveraceae) besides of the dominant known alkaloids (-)-mecambrine (1), (-)-mecambridine (2), (-)-flavinantine (4) and (+)-magnoflorine (5), and a small amount of (+)-mecambroline (3a). Minute quantities of protopine, allocryptopine, roemeroline, papaverrubine D and C, berberine, coptisine, corysamine and palmatine were identified by thin layer chromatography (TLC). From M. robusta HOOK. f. et THOMS., protopine, (-)-amurensinine (6) and two incompletely characterized alkaloids MRO 1 and MRO 2 were isolated, and allocryptopine, cryptopine, rhoeadine, 6-methoxy-2-methyl-1,2,3,4-tetrahydro-β-carboline, alkaloid MR 1, coptisine, corysamine, magnoflorine, corytuberine and N-methylamurensininium salt were detected on TLC.

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Berkova, Strahil, and Rawia Zayed. "Comparison of Tropane Alkaloid Spectra Between Datura innoxia Grown in Egypt and Bulgaria." Zeitschrift für Naturforschung C 59, no. 3-4 (April 1, 2004): 184–86. http://dx.doi.org/10.1515/znc-2004-3-409.

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The alkaloid spectra of Datura innoxia plants grown in Egypt and Bulgaria were investigated by GC-MS. Thirty-eight alkaloids were detected in the roots, leaves and fruits of the plants. Five new alkaloids for D. innoxia are reported. Alkaloid spectra of Egyptian and Bulgarian plants differ significantly in respect to their alkaloid composition and main alkaloids accumulated in the plant organs.

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Chaplin, JF. "Die Züchtung von TabakimHinblick auf verschieden hohe Alkaloidgehalte - Tobacco Breeding in View of Different Levels of Alcaloid Contents." Beiträge zur Tabakforschung International/Contributions to Tobacco Research 14, no. 1 (December 1, 1987): 1–9. http://dx.doi.org/10.2478/cttr-2013-0578.

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AbstractTwo systems of genetic control are involved in the quality and level of total alkaloids in tobacco (Nicotianatabacum L.). A single locus controls the conversion of nicotine to nornicotine and two loci control total alkaloid levels. These levels may be further modified by minor genes or quantitative factors. Breeding lines and cultivars of flue-cured tobacco have been developed with varying levels of total alkaloids (nicotine). Levels of nicotine in tobacco range from near zero in cigar strains up to 4.5 % in Burley varieties. Within the collection of N. tabacumgermplasm and Nicotiana species maintained by the Agricultural Research Service of the U.S. Department of Agriculture, total alkaloid levels range from 0.20 % to 7.87 %. Flue-cured lines of tobacco with varying levels of total alkaloids have been developed and characterized. In general the high alkaloid lines had the highest grade indexes. All of the extremely low alkaloid lines were also lower in grade index indicating that total alkaloids do have some relationship with the grade index. The high total alkaloid lines were lower in yield. However, it is believed that the levels of total alkaloids reported do not result from yield variation. N. rustica generally has considerably higher total alkaloid levels, based on percent dry weight, than N. tabacum. With the stabilizing of a low total alkaloid line of N. tabacum (0.20 %) it was feasible to introgress the gene(s) for alkaloid production from N. rustica into N. tabacum. Indications are that more than one gene is responsible for total alkaloid production in this material. Also preliminary indications are that the genes for total alkaloid production in N. rustica may be the same as those in N. tabacum.

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Sun, Bo, Yu-Xiao Tian, Fen Zhang, Qing Chen, Yong Zhang, Ya Luo, Xiao-Rong Wang, Fu-Cheng Lin, Jun Yang, and Hao-Ru Tang. "Variations of Alkaloid Accumulation and Gene Transcription in Nicotiana tabacum." Biomolecules 8, no. 4 (October 15, 2018): 114. http://dx.doi.org/10.3390/biom8040114.

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To increase the understanding of alkaloid biosynthesis in Nicotiana tabacum during whole plant growth periods, variations of the contents of alkaloids and the transcription of key biosynthetic genes in fresh leaves were investigated in three varieties at five developmental stages. Six alkaloids were analyzed by gas chromatograph–mass spectrometry (GC–MS) and the most abundant alkaloid was observed during the upper leaves maturing stage in the varieties, among which the alkaloid content of K326 was the highest. Considering the genetic effect, variance analysis indicated that the developmental stage played a predominant role in alkaloid accumulation. Moreover, the levels of biosynthetic gene transcripts in the leaves at the vigorous growing stage might contribute to the contents of alkaloids in the leaves during the maturing stages. To further illuminate the metabolism of alkaloid biosynthesis, a correlation among alkaloids was also documented.

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Doncheva, Tsvetelina, Gabriela Yordanova, Vassil Vutov, Nadezhda Kostova, and Stefan Philipov. "Comparative Study of Alkaloid Pattern of Four Bulgarian Fumaria Species." Natural Product Communications 11, no. 2 (February 2016): 1934578X1601100. http://dx.doi.org/10.1177/1934578x1601100220.

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The alkaloid pattern of four Fumaria species ( Fumaria kralikii, Fumaria rostellata, Fumaria schleicherii, Fumaria thuretii) growing in Bulgaria was investigated by GC-MS and twenty isoquinoline alkaloids were determined. Phytochemical investigation of the alkaloid composition on Fumaria thuretii Boiss was made for the first time. The alkaloid profile of the species was compared at two levels, between different species and within two species from different habitats. Two chemotypical groups, based on the types of isoquinoline alkaloids were suggested. To group A belong species F. kralikii, F. rostellata (F. r. 1) and F. thuretii containing more than 50% spirobenzylisoquinoline alkaloids of the crude alkaloid mixtures. To group B belong species F. rostellata (F. r. 2) and F. schleicherii containing more than 40% protopine alkaloids and relatively high percentage phthaldeisoquinoline alkaloids (11–19%). In group A phthaldeisoquinoline alkaloids were not detected.

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Dissertations / Theses on the topic "Alkaloid"

1

Mathews, C. J. "Alkaloid synthesis." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.238202.

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Atkinson, Jonathan D. M. "Alkaloid synthesis." Thesis, University of Oxford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302885.

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Callaghan, Owen. "Synthetic and mechanistic studies in free radical." Thesis, University of Strathclyde, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366957.

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Ali, Naji M. "Studies in alkaloid synthesis." Thesis, University of East Anglia, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327933.

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Walsma, J. "Tropane alkaloid production by Datura." Thesis, De Montfort University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383103.

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Glenn, Weslee S. (Weslee Sinclair). "Understanding and manipulating alkaloid biosynthesis." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/84374.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2013.
Cataloged from PDF version of thesis. Vita.
Includes bibliographical references.
Humans have exploited plant alkaloids as medicines since at least the Neolithic Era. Today, alkaloids such as vinblastine (isolated from Catharanthus roseus) and morphine (isolated from Papaver somniferum) are prescribed to treat various cancers and relieve pain, respectively. Despite this storied use and palpable presence in the current pharmacopeia, relatively little is known about the biosynthesis, regulation and transport of these molecules. For example, monoterpene indole alkaloid (MIA) biosynthesis, a set of metabolic pathways that produces hundreds of bioactive natural products, has not been fully elucidated in any organism. Here we examine the biosynthesis of secologanin, which contributes the monoterpene moiety to all MIAs. Specifically, we excavate C. roseus transcriptomic datasets to identify 1 0-hydroxygeraniol oxidoreductase, a missing step in secologanin biosynthesis. 10-hydroxygeraniol oxidoreductase catalyzes the oxidation of both hydroxyl moieties of 10-hydroxygeraniol to form 10-oxogeranial, which is the substrate for iridoid synthase, the reductive cyclase that assembles the characteristic iridoid scaffold. Despite having an incomplete understanding of MIA biosynthesis, several engineering strategies have been successfully deployed to incorporate halogenation into the MIA machinery and yield halogenated alkaloids. Although alkaloids and plant natural products have been used to treat various diseases, these compounds have not evolved specifically to do so. Therefore, these compounds frequently require editing to effectively tune their biological and pharmacological activities. We also describe efforts to reengineer tryptophan halogenase RebH to preferentially install chlorine onto tryptamine, the direct indole precursor for the MIAs. After reengineering RebH, we then overexpressed the tryptamine-specific mutant RebH Y455W and flavin reductase RebF in C. roseus and observed the de novo biosynthesis of a chlorinated unnatural natural product 12-chloro- 19,20-dihydroakuammicine. Lastly, we describe the serendipitous discovery of a P. somniferum codeine-Odemethylase mutant that selectively demethylates codeine, a benzylisoquinoline alkaloid involved in morphine biosynthesis, instead of both codeine and thebaine. This mutant may selectively disable a redundant route in the biosynthesis of morphine that has been associated with poor seed and licit opium quality.
by Weslee S. Glenn.
Ph.D.

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7

Boynton, Carole M. "Alkaloid synthesis via novel azabicycles." Thesis, Sheffield Hallam University, 1988. http://shura.shu.ac.uk/19384/.

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A basic introduction to pyrrolizidine and indolizidine alkaloids has been described along with a selection of recent syntheses of the said compounds. Cycloalkene synthesis by intramolecular Wittig reaction has been reviewed and we describe the utility of this strategy in the formation of nitrogen-bridgehead bicycles which can then be used in alkaloid synthesis. Our initial studies on the viability of this strategy in the synthesis of fused pyrrolidone systems employed a Wittig reaction between 5-acetylpyrrolidin-2-one and vinylphosphonium salts. A comparison was made between three different vinylphosphonium salts but in each case the bicycle formed was present as a mixture with the Wittig by-product triphenylphosphine oxide. Various solutions to this problem were investigated including modification of the bicycle and also the formation of a water soluble vinylphosphonium salt. The difficulties encountered led us to the use of a vinylphosphine oxide which resulted in the formation of 5,6,7,7a-tetrahydro-1-methyl-2-phenylthio-3H-pyrrolizin-5-one in good yields. Desulphurisation gave 5,6,7,7a-tetrahydro-1-methyl-3H-pyrrolizin-5-one which has previously been converted into (+/-)-supinidine. Thus our method constitutes a formal total synthesis of (+/-)-supinidine. Attempts at the preparation of analogues of 5-acetylpyrrolidin-2-one were unsuccessful but were in their preliminary stages at the close of the work. Reaction of 5-acetylpyrrolidin-2-one with cyclopropylphosphonium salts were attempted without success but it is felt that the use of cyclopropylphosphine oxides would solve this problem. Attempts at performing an intramolecular Wittig reaction on the imide carbonyl of succinimide using both cyclopropylphosphonium salts and butadienylphosphonium salts were unsuccessful but our investigations gave an insight into the cause of the failure forcing conditions need to be employed to effect the cyclisation.

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8

Kuschnir, R. V. "Koffein – alkaloid fur gute laune." Thesis, Київський національний університет технологій та дизайну, 2018. https://er.knutd.edu.ua/handle/123456789/11392.

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Ermayanti, Tri Muji. "Alkaloid production from root cultures." Thesis, Ermayanti, Tri Muji (1993) Alkaloid production from root cultures. PhD thesis, Murdoch University, 1993. https://researchrepository.murdoch.edu.au/id/eprint/51711/.

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Root culture was used as a method for swainsonine (1,2,8-trihydroxyoctaindolizine) production from the Australian native plant Sxvainsona galegifolia (Darling pea). Root cultures were established either from seedling roots or after infection of plant organs with Agrobacterium rhizogenes. Murashige and Skoog (MS) liquid medium with 5 µM IBA was the best medium for growth of untransformed isolated roots while MS liquid medium with no hormones was best for transformed roots. Swainsonine produced by root cultures of S. galegifolia reached a maximum 30 - 35 days after subculture, and the identity of the compound was confirmed by its GC retention time and mass spectrum in comparison to swainsonine from intact plants and the swainsonine standard (Sigma Co., USA). Roots and shoots from glasshousegrown plants had a similar swainsonine concentration to shoots of plants grown in vitro. The concentration of swainsonine in transformed roots was higher than in untransformed roots. Tests of the effect of plant genotype and A. rhizogenes strain LBA 9402 showed that plant genotype influences swainsonine level in transformed roots, but that different transformation events in one genotype resulted in equally large differences in the level of swainsonine. Polyploid roots might be expected to show higher levels of secondary metabolites than diploids, but attempts to induce polyploidy through use of colchicine, transformation of cotyledons, or differentiation of roots from callus was unsuccessful. Roots from callus showed lowered swainsonine levels concomitant with a reduction in modal chromosome number from 32 to 18. In normal cultures of untransformed or transformed roots, the level of swainsonine in the medium was negligible. Stimulation of production of swainsonine and its release into the medium was attempted using CUSO4, reduction of medium pH, and supply of swainsonine precursors. Addition of 0.5 - 2.0 mM CUSO4 for 1 - 4 days to the culture medium for transformed roots increased swainsonine level and stimulated release of swainsonine to the medium. The maximum swainsonine concentration was achieved after treatment with 2.0 mM CUSO4 for 2 days. Reduction of medium pH from 5.7 to 2.7 for 1 day also increased swainsonine level in transformed roots and in the medium. The precursors pipecolic acid and malonic acid at 0.005 - 2.0 mM given for 1 - 12 days in MS liquid medium increased root growth and swainsonine level. The maximum swainsonine level was found in transformed roots with 2 mM of pipecolic acid for 6 days. Addition of 1 mM malonic acid for each of 4 successive days also increased growth of transformed roots and swainsonine level but the increase did not exceed that achieved by a single supplementation. This report adds to the evidence that roots transformed with A. rhizogenes show high and stable levels of secondary metabolite production. Transformed roots of S. galegifolia had a swainsonine production almost 10-fold that measured in intact plants grown under glasshouse condition. The addition of precursors increased the level to almost 20-fold. Root culture was also attempted for castanospermine production by Castanospermum australe. Growth of untransformed root cultures was unsuccessful. Untransformed roots grew in solid medium but failed to grow in liquid medium. It was not possible to induce transformed roots. No roots were obtained after infection using a range of A. rhizogenes strains or when the bacterium was pre-incubated with acetosyringone in the medium.

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Antropow, Alyssa Hope. "Synthesis and anticancer evaluation of agelastatin alkaloid derivatives and enantioselective total synthesis of aspidosperma alkaloids." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/118214.

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Thesis: Ph. D. in Organic Chemistry, Massachusetts Institute of Technology, Department of Chemistry, 2018.
Cataloged from PDF version of thesis. Vita.
Includes bibliographical references.
I. Synthesis and Evaluation of Agelastatin Derivatives as Potent Modulators for Cancer Invasion and Metastasis The synthesis of new agelastatin alkaloid derivatives and their anticancer evaluation in the context of the breast cancer microenvironment is described. A variety of Ni -alkyl and C5-ether agelastatin derivatives were accessed via application of our strategy for convergent imidazolone synthesis. We have discovered that agelastatin alkaloids are potent modulators for cancer invasion and metastasis at non-cytotoxic doses. We discuss the increased potency of (-)-agelastatin E as compared to (-)-agelastatin A in this capacity, in addition to identification of new agelastatin derivatives with activity that is statistically equivalent to (-)-agelastatin E. II. Enantioselective Synthesis of (-)-Vallesine: Late-stage C17-Oxidation via Complex Indole Boronation The first enantioselective total synthesis of (-)-vallesine via a strategy that features a late-stage regioselective C17-oxidation followed by a highly stereoselective transannular cyclization is described. The versatility of this approach is highlighted by divergent synthesis of the archetypal alkaloid of this family, (+)-aspidospermidine, and an A-ring oxygenated derivative (+)- deacetylaspidospermine, the precursor to (-)-vallesine, from a common intermediate. III. Enantioselective Total Synthesis of (-)-Jerantinine A from (-)-Melodinine P via Bio-Inspired A-Ring Oxidation The first enantioselective synthesis of (-)-melodinine P and its direct conversion to related alkaloid (-)-jerantinine A is described. A key para-aza-quinone methide pentacyclic intermediate enables A-ring to C-ring oxidation state transfer. Our synthesis is streamlined through the development of two multi-step single-pot procedures which proceed with high efficiency. We further demonstrate the utility ofpara-aza-quinone methide intermediates in our strategy for CI6-methoxylation which provides entry to the (-)-jerantinine alkaloid family.
by Alyssa Hope Antropow.
Ph. D. in Organic Chemistry

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Books on the topic "Alkaloid"

1

Głowacki, Aleksander. Alkaloid. Warszawa: Powergraph, 2012.

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Alkaloid synthesis. Heidelberg: Springer, 2012.

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Knölker, Hans-Joachim, ed. Alkaloid Synthesis. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-25529-8.

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Ali, Naji M. Studies in alkaloid synthesis. Norwich: University of East Anglia, 1989.

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Aniszewski, Tadeusz. Alkaloids--secrets of life: Alkaloid chemistry, biological significance, applications and ecological role. Amsterdam: Elsevier, 2007.

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Walsma, J. Tropane alkaloid production by Datura. Leicester: Leicester Polytechnic, 1988.

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Burbidge, Alan. Tropane alkaloid production by genetically manipulated datura. Leicester: Leicester Polytechnic, Department ofApplied Biology and Biotechnolgy, 1992.

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Ouali, Dehimi. Enantioselective synthesis of novel Corynanthe indole alkaloid synthons. Salford: University of Salford, 1991.

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Owen, David Alan. Aryl substituted cyclohexadienyl iron complexes in alkaloid synthesis. Norwich: University of East Anglia, 1990.

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Redemann, Thomas. Kombinatorische Synthese von Alkaloid-Analoga, Peptidomimetika und Alamethicin-Analoga. [S.l.]: [s.n.], 1997.

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Book chapters on the topic "Alkaloid"

1

Böning, Dieter, Michael I. Lindinger, Damian M. Bailey, Istvan Berczi, Kameljit Kalsi, José González-Alonso, David J. Dyck, et al. "Alkaloid." In Encyclopedia of Exercise Medicine in Health and Disease, 52. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-29807-6_2061.

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Neelabh. "Alkaloid." In Encyclopedia of Animal Cognition and Behavior, 1–3. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-47829-6_218-1.

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Neelabh. "Alkaloid." In Encyclopedia of Animal Cognition and Behavior, 172–74. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-319-55065-7_218.

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Dawson, Ray F. "Alkaloid Biogenesis." In Advances in Enzymology - and Related Areas of Molecular Biology, 203–51. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2006. http://dx.doi.org/10.1002/9780470122532.ch5.

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Leete, Edward. "Alkaloid Biosynthesis." In Advances in Enzymology - and Related Areas of Molecular Biology, 373–422. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2006. http://dx.doi.org/10.1002/9780470122778.ch9.

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Stevens, R. V. "Alkaloid Synthesis." In Total Synthesis of Natural Products, 439–554. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2007. http://dx.doi.org/10.1002/9780470129661.ch3.

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Ashihara, Hiroshi, Shinjiro Ogita, and Alan Crozier. "Purine Alkaloid Metabolism." In Plant Metabolism and Biotechnology, 163–89. Chichester, UK: John Wiley & Sons, Ltd, 2011. http://dx.doi.org/10.1002/9781119991311.ch6.

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Desgagné-Penix, Isabel, and Peter J. Facchini. "Benzylisoquinoline Alkaloid Biosynthesis." In Plant Metabolism and Biotechnology, 241–61. Chichester, UK: John Wiley & Sons, Ltd, 2011. http://dx.doi.org/10.1002/9781119991311.ch9.

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Breitmaier, Eberhard. "Der Begriff Alkaloid." In Teubner Studienbücher Chemie, 9–10. Wiesbaden: Vieweg+Teubner Verlag, 2002. http://dx.doi.org/10.1007/978-3-322-92687-6_1.

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Breitmaier, Eberhard. "Exemplarische Alkaloid-Synthesen." In Teubner Studienbücher Chemie, 107–54. Wiesbaden: Vieweg+Teubner Verlag, 2002. http://dx.doi.org/10.1007/978-3-322-92687-6_7.

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Conference papers on the topic "Alkaloid"

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Menendez Perdomo, Ivette. "Benzylisoquiline alkaloid biosynthesis in sacred lotus." In ASPB PLANT BIOLOGY 2020. USA: ASPB, 2020. http://dx.doi.org/10.46678/pb.20.1332313.

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Le, N.-T.-H., L. Pieters, and E. Tuenter. "A new alkaloid from Scadoxus multiflorus." In GA – 70th Annual Meeting 2022. Georg Thieme Verlag KG, 2022. http://dx.doi.org/10.1055/s-0042-1759107.

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Le, Hien T. N., Luc Pieters, and Emmy Tuenter. "A new alkaloid from Pancratium maritimum L." In GA – 69th Annual Meeting 2021, Virtual conference. Georg Thieme Verlag, 2021. http://dx.doi.org/10.1055/s-0041-1736841.

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Трошина, Лариса, Larisa Troshina, Татьяна ЯГОВЕНКО, and Tat'yana YaGOVENKO. "DYNAMICS OF ALKALOID ACCUMULATION AND REDISTRIBUTION IN NARROW-LEAFED LUPIN." In Multifunctional adaptive feed production. ru: Federal Williams Research Center of Forage Production and Agroecology, 2019. http://dx.doi.org/10.33814/mak-2019-21-69-26-31.

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The article presents alkaloid accumulation and redistribution in germinative seed of nar-row-leafed lupin as well as the dynamics of alkaloid content in three genotypes of narrow-leafed lupin plants during ontogenesis. Specialties of accumulation of these compounds under different conditions are shown. The stage “beginning of pod formation — maturing” is the most susceptible to temperature changes in vegetation of narrow-leafed lupin.

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"Alkaloid chemophenetics and transcriptomics of the Nicotiana genus." In Plant Genetics, Genomics, Bioinformatics, and Biotechnology. Novosibirsk ICG SB RAS 2021, 2021. http://dx.doi.org/10.18699/plantgen2021-085.

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Zielińska, S., A. Junka, M. Wójciak-Kosior, I. Sowa, C. Zidorn, SS Çiçek, M. Dziągwa-Becker, et al. "The relevance of alkaloid proportions in Chelidonium maius extracts." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3400100.

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Liu, Yang-yang, and Chang-jiang Liu. "Extraction Process Optimization of Total Alkaloid from Actinidia arguta." In 2015 International Conference on Materials, Environmental and Biological Engineering. Paris, France: Atlantis Press, 2015. http://dx.doi.org/10.2991/mebe-15.2015.32.

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Kaminski, Kacper. "Alkaloid chemophenetics and transcriptomics analysis of the Nicotiana genus revealed evident sectional classification patterns and their correlation with alkaloid biosynthesis gene expression." In ASPB PLANT BIOLOGY 2020. USA: ASPB, 2020. http://dx.doi.org/10.46678/pb.20.1332319.

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Fürst, R. "The Amaryllidaceae alkaloid narciclasine as modulator of endothelial activation processes." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3399678.

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Kunukcu, Y. Kaçar, and U. Wiesmann. "Activated Sludge Treatment and Anaerobic Digestion of Opium Alkaloid Factory." In World Water and Environmental Resources Congress 2004. Reston, VA: American Society of Civil Engineers, 2004. http://dx.doi.org/10.1061/40737(2004)291.

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Reports on the topic "Alkaloid"

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Doncheva, Tsvetelina, Nadezhda Kostova, Vassil Vutov, Ina Aneva, and Stefan Philipov. Comparative Study of the Alkaloid Composition in Some Bulgarian Species of Genus Hypecoum. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, June 2019. http://dx.doi.org/10.7546/crabs.2019.06.04.

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Lewinsohn, Efraim, Peter Facchini, and Frederic Marsolais. Comparative Functional Genomics as a Platform to Investigate Ephedrine Alkaloid Biosynthesis in Plants. United States Department of Agriculture, January 2009. http://dx.doi.org/10.32747/2009.7613886.bard.

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Levy, Arieh, Donald Bills, Dan Palevitch, An Fei Hsu, and David Lavie. Genetic and Chemical Control of Alkaloid Biosynthesis in Papaver bracteatum and Papaver somniferum. United States Department of Agriculture, July 1986. http://dx.doi.org/10.32747/1986.7598189.bard.

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Veilleux, Richard E., Jossi Hillel, A. Raymond Miller, and David Levy. Molecular Analysis by SSR of Genes Associated with Alkaloid Synthesis in a Segregating Monoploid Potato Family. United States Department of Agriculture, May 1994. http://dx.doi.org/10.32747/1994.7570550.bard.

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More than 15,000 anthers of an interspecific hybrid (CP2) between two diploid (2n=2x=24) potato species, Solanum chacoense (weedy) and S. phureja (cultivated), were cultured to generate a family of monoploid (haploid, 2n-1x=12) plants. Of 260 regenerated plants, 34 were monoploid, 210 diploid and 16 tetraploid. SSR analysis revealed that six monoploids were genetically identical and 14 diploids were homozygous, thus limiting the population to 42 (28 monoploids and 14 homozygous diploids). New microsatellite loci were developed for potato from database sequences (15), a conventional genomic library (6), an enriched library (18) and tomato (11). Of these, 13 were polymorphic in the CP2 family and 11 were used to study genetic segregatin. Four of 11 exhibited skewed segregation in the monoploid family. Seven of 18 microsatellite markers were polymorphic and informative on a set of 12 tetraploid potato cultivars. Acetylleptinidine (ALD) is the aglycone of leptines, a natural defense against insects, especially the highly destructuve Colorado potato beetle. ALD is absend in S. phureja but highly expressed in the S. chacoense parent of CP2. A backcross population between CP2 and tis S. phureja parent was used to examine segregation for ALD. Bulks of 10 backcross individuals that expressed ALD and 10 that did not were used to identify putative RAPD markers associatd with the trait. Of 80 primers tested, one putative marker amplified by OPQ02 was present in eight of ten individuals comprising the high bulk and absent in all 10 individuals comprising the low bulk. This is a putative marker for ALD expression in potato.

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Annunziato, Dominick. HPLC Sample Prep and Extraction SOP v1.3 for Fungi. MagicMyco, August 2023. http://dx.doi.org/10.61073/sopv1.3.08.11.2023.

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medicine, industry, and biotechnology. Fungi produce a wide range of bioactive compounds, such as alkaloids, antibiotics, antifungals, immunomodulators, anticancer agents, enzymes, and vitamins. However, these compounds are often locked inside the fungal cell wall, which is composed of chitin, a tough substance that is dif�icult to digest by humans1. Therefore, it is essential to have a good extraction technique that can break down the chitin and release the valuable compounds from the fungi, this is especially essential in the laboratory for accurate lab assays and potency determination during routine HPLC chromatography analysis. During licensure and/ or certi�ication any given lab will be required to take a pro�iciency test which gauges the lab’s pro�iciency at measuring a given matrices for accurate evaluation. They evaluate our abilities to run the gear and accurately measure the potency of what was extracted; however, at the time of this writing none existed for extraction of the fungal material itself, so this remains a variable between testing labs. It is important that we openly share our extraction techniques for evaluating fungi materials speci�ically for the clean extraction of active alkaloids for which potency can be measure via chromatography and/or spectrometry devices. In this way hopefully creating less variables between testing lab and more concise results. In this paper, we present a novel sample prep and extraction technique for fungi that uses speci�ic solvent composition in conjunction with M.A.E (microwave assisted extraction) in 75% methanol , 25% water which helps break the cell wall to release the compounds. Also used is an ultrasonication unit and vortex mixer. Our technique quickly releases all the available alkaloids for accurate chromatography measurements in just two hours, forty-�ive minutes with minimal handling. We demonstrate the effectiveness and ef�iciency of our technique by applying it to magic mushroom fruit bodies for the extraction of tryptamines namely psilocybin and its active derivative psilocin; however, this technique can be used for other species of fungi and compounds like Cordyceps/ cordycepin or Lions’ mane/ erinacines, etc.. We also compare our technique with other popular methods in terms of extraction techniques, digestion times and solvent compositions. Our results show that our technique is superior to the others in terms of time and effectiveness while pulling all the active compounds and not degrading them. Our extraction technique for fungi chromatography analysis offers a new and improved way to access the natural products of fungi and explore their potential for various biotechnological applications. We hope that our technique will inspire further research and innovation in the field of fungal extraction and natural product.

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Skone, Timothy J. Brine Chlor-alkali Processing. Office of Scientific and Technical Information (OSTI), July 2014. http://dx.doi.org/10.2172/1508996.

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Pereboom, D. P. K. H., A. Veršilovskis, P. P. J. Mulder, M. de Nijs, and J. G. J. Mol. Proficiency test for ergot alkaloids in cereals : EURL-PT-MP03 (2019). Wageningen: Wageningen Food Safety Research, 2020. http://dx.doi.org/10.18174/526444.

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Struble, Leslie J. Alkali-silica reaction in concrete. Gaithersburg, MD: National Bureau of Standards, 1985. http://dx.doi.org/10.6028/nbs.ir.85-3116.

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French, T. R., and C. B. Josephson. Surfactant-enhanced alkaline flooding with weak alkalis. Office of Scientific and Technical Information (OSTI), February 1991. http://dx.doi.org/10.2172/6089128.

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Hou, Hongtao. The reaction dynamics of alkali dimer molecules and electronically excited alkali atoms with simple molecules. Office of Scientific and Technical Information (OSTI), December 1995. http://dx.doi.org/10.2172/206522.

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