Relevant bibliographies by topics / Alkaloider. Alkaloids Alkaloids Benzodiazepines Benzodiazepines

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters

Academic literature on the topic 'Alkaloider. Alkaloids Alkaloids Benzodiazepines Benzodiazepines'

Author: Grafiati
Published: 4 June 2021
Last updated: 9 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Alkaloider. Alkaloids Alkaloids Benzodiazepines Benzodiazepines.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Alkaloider. Alkaloids Alkaloids Benzodiazepines Benzodiazepines"

1

Batiha, Gaber El-Saber, Luay M. Alkazmi, Eman H. Nadwa, Eman K. Rashwan, Amany Magdy Beshbishy, Hazem Shaheen, and Lamiaa Wasef. "Physostigmine: A Plant Alkaloid Isolated from Physostigma venenosum: A Review on Pharmacokinetics, Pharmacological and Toxicological Activities." Journal of Drug Delivery and Therapeutics 10, no. 1-s (February 15, 2020): 187–90. http://dx.doi.org/10.22270/jddt.v10i1-s.3866.

Full text
Abstract:
Medicinal plants have been documented as an important source for discovering new pharmaceutical molecules that have been used to treat serious diseases. Strikingly, previous reports stated that natural products and their derived compounds exhibit lesser side effects and improved efficacy than other synthetic counterparts. Physostigmine, a parasympathomimetic plant alkaloid isolated from the West African perennial shrub Physostigma venenosum, it shows a narrow therapeutic index and a short life span, despite its ability to penetrate the blood-brain barrier (BBB). It is a widely known reversible butyrylcholinesterase (BuChE) and acetylcholinesterase (AChE) inhibitor and has been documented to treat various ailments such as Alzheimer’s disease. Pharmacologically, physostigmine was first reported as an antidote for atropine scopolamine and belladonna alkaloids toxicity. Recently, it has been documented as a therapy for treating several ailments including glaucoma, myasthenia gravis and the intoxication caused by tricyclic antidepressant overdoses, anti-histamines, antipsychotics, and benzodiazepines. Physostigmine has been reported to be absorbed from the gastrointestinal tract and showed short half-life, as, after the oral administration of 2 mg of physostigmine salicylate, the peak plasma concentration reached to 30 minutes. This review examines the biological activities, pharmacokinetics, and toxicity of physostigmine extracted from P. venenosum. Keywords: Physostigma venenosum, Physostigmine, pharmacological activities, acetylcholinesterase and butyrylcholinesterase inhibitor.
APA, Harvard, Vancouver, ISO, and other styles
2

Nurmilatina, Nurmilatina. "Analisis Komposisi Kimia Daun Kelakai (Stenochlaena palustris Bedd.) dengan Berbagai Pelarut menggunakan GCMS (Chemical Composition Analysis of Stenochlaena palustris Bedd. Leaves using Various Solvents on GCMS)." Jurnal Riset Industri Hasil Hutan 9, no. 1 (October 1, 2017): 9–16. http://dx.doi.org/10.24111/jrihh.v9i1.2952.

Full text
Abstract:
The selection of suitable solvents is essential for extracting the desired compounds from plant cells. GCMS is an instrument that can be used to identify such compounds. Therefore, this study objective is to extract kelakai leaves using various solvents and analyze the composition of chemical compounds using GCMS instrument. Kelakai leaves was extracted using three solvent variations: a1 = aquadest, a2 = ethanol, and a3 = ethanol 50%; and the maceration time variations: b1 = 1 day, b2 = 2 days, and b3 = 3 days. The best extraction method was aquadest as solvent and one day maceration. The chemical compound extracted were phenolic, alkaloids and terpenoids, such as 2,5-bis [(trimethylsilyl) oxy] benzaldehyde 1,86%, linalool 1,28%, phenethyl alcohol 3,55% and 7-chloro-5-phenyl-1-(trimethylsilyl)-1,3-dihydro-2H-1,4-benzodiazepines-2-on 1,16 % db.Keywords: composition analysis, GCMS, maceration, Stenochlaena palustris Bedd.
APA, Harvard, Vancouver, ISO, and other styles
3

Davidsen, Jesper Rømhild, Lars Christian Lund, Christian B. Laursen, Jesper Hallas, and Daniel Pilsgaard Henriksen. "Dynamics in diagnoses and pharmacotherapy before and after diagnosing idiopathic pulmonary fibrosis." ERJ Open Research 6, no. 4 (September 17, 2020): 00479–2020. http://dx.doi.org/10.1183/23120541.00479-2020.

Full text
Abstract:
BackgroundIdiopathic pulmonary fibrosis (IPF) is a well-characterised interstitial lung disease. Typically, IPF diagnosis is delayed due to nonspecific symptoms, but can also be delayed due to treatment attempts on false indication or due to treatment targeting common comorbidities. This observational study aimed to assess the dynamics in the medication and diagnosis patterns in the period before and after an IPF diagnosis.MethodsWe identified all Danish patients with IPF between 2002 and 2017. We evaluated new and ongoing drug treatments and incident diagnoses 36 months before and 12 months after an IPF diagnosis by use of Danish nationwide registries. To aid interpretation, 10 random controls were recruited for each case.ResultsA total of 650 IPF patients were identified (median age 73 years (interquartile range 65–78), 70.3% males). Prior to the IPF diagnosis, the most prevalent diagnoses were dyspnoea and non-IPF interstitial lung diseases. For drug use, IPF patients had higher initiation rates for antibiotics, oral corticosteroids and mucolytics. In terms of drug volume, IPF patients used more respiratory drugs, antibiotics, immunosuppressants, corticosteroids, proton pump inhibitors, benzodiazepines and opium alkaloids within the 6 months preceding their IPF diagnosis, compared to the controls. Overall drug use decreased after an IPF diagnosis, mainly due to a reduced glucocorticoid and cardiovascular drug use.ConclusionAmong IPF patients, an increased drug use was observed for diagnoses with symptoms overlapping those of IPF, particularly this was observed during the last 6 months before an IPF diagnosis. This emphasises the need for an increased IPF awareness.
APA, Harvard, Vancouver, ISO, and other styles
4

Sudarma, I. Made, and John Bremner. "SYNTHESIS OF THE ISOQUINO-[2,1-c][1,3]-BENZODIAZEPINE DERIVATIVE FROM PAPAVERINE." Indonesian Journal of Chemistry 7, no. 3 (June 20, 2010): 324–26. http://dx.doi.org/10.22146/ijc.21677.

Full text
Abstract:
The objective of this research was to synthesize isoquino[2,1-c][1,3]benzodiazepine from papaverine alkaloid. Functional Group Interconversion (FGI) and Carbon -Nitrogen bond connection approach was investigated. Papaverine (1) was nitrated by HNO3 to compound (2) and followed by reduction with Sn and HCl to afford aminonorlaudanosine (3). Formation of cyclic benzodiazepine (4) was achieved by reaction of (3) with CS2. Products of reactions were confirmed by Nuclear Magnetic Resonances (n.m.r), Mass Spectrum, and Fourier Transform Infra Red (FTIR). Keywords: isoquino[2,1-c][1,3]benzodiazepine, papaverine
APA, Harvard, Vancouver, ISO, and other styles
5

Cui, Chuan-Ming, Xiao-Ming Li, Chun-Shun Li, Hao-Fen Sun, Shu-Shan Gao, and Bin-Gui Wang. "Benzodiazepine Alkaloids from Marine-Derived Endophytic FungusAspergillus ochraceus." Helvetica Chimica Acta 92, no. 7 (July 2009): 1366–70. http://dx.doi.org/10.1002/hlca.200900084.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Munir, Samman, Aqsa Shahid, Bilal Aslam, Usman Ali Ashfaq, Muhammad Sajid Hamid Akash, Muhammad Akhtar Ali, Ahmad Almatroudi, Khaled S. Allemailem, Muhammad Shahid Riaz Rajoka, and Mohsin Khurshid. "The Therapeutic Prospects of Naturally Occurring and Synthetic Indole Alkaloids for Depression and Anxiety Disorders." Evidence-Based Complementary and Alternative Medicine 2020 (October 16, 2020): 1–11. http://dx.doi.org/10.1155/2020/8836983.

Full text
Abstract:
Depression and anxiety are the most common disorders among all age groups. Several antidepressant drugs including benzodiazepine, antidepressant tricyclics, azapirone, noradrenaline reuptake inhibitors, serotonin selective reuptake inhibitors, serotonin, noradrenaline reuptake inhibitors, and monoamine oxidase inhibitors have been used to treat these psychiatric disorders. However, these antidepressants are generally synthetic agents and can cause a wide range of side effects. The potential efficacy of plant-derived alkaloids has been reviewed against various neurodegenerative diseases including Alzheimer’s disease, Huntington disease, Parkinson’s disease, schizophrenia, and epilepsy. However, data correlating the indole alkaloids and antidepressant activity are limited. Natural products, especially plants and the marine environment, are rich sources of potential new drugs. Plants possess a variety of indole alkaloids, and compounds that have an indole moiety are related to serotonin, which is a neurotransmitter that regulates brain function and cognition, which in turn alleviates anxiety, and ensures a good mood and happiness. The present review is a summary of the bioactive compounds from plants and marine sources that contain the indole moiety, which can serve as potent antidepressants. The prospects of naturally occurring as well as synthetic indole alkaloids for the amelioration of anxiety and depression-related disorders, structure-activity relationship, and their therapeutic prospects have been discussed.
APA, Harvard, Vancouver, ISO, and other styles
7

Helbig, Florian, Jörg Steighardt, and Werner Roos. "Uric Acid Is a Genuine Metabolite of Penicillium cyclopium and Stimulates the Expression of Alkaloid Biosynthesis in This Fungus." Applied and Environmental Microbiology 68, no. 4 (April 2002): 1524–33. http://dx.doi.org/10.1128/aem.68.4.1524-1533.2002.

Full text
Abstract:
ABSTRACT On searching for endogenous, low-molecular-weight effectors of benzodiazepine alkaloid biosynthesis in Penicillium cyclopium uric acid was isolated from ethanolic or autoclaved mycelial extracts of this fungus. The isolation was based on a three-step high-pressure liquid chromatography procedure guided by a microplate bioassay, and uric acid was identified by mass spectrometry and the uricase reaction. Conidiospore suspensions that were treated with this compound during the early phase of outgrowth developed emerged cultures with an enhanced rate of alkaloid production. Uric acid treatment did not increase the in vitro measurable activity of the rate-limiting biosynthetic enzyme, cyclopeptine synthetase. However, these cultures displayed a reduced rate of uptake of the alkaloid precursor l-phenylalanine into the vacuoles of the hyphal cells as assayed in situ. It is suggested that the depressed capacity of vacuolar uptake caused by the contact of outgrowing spores with uric acid liberated from hyphal cells results in an enhanced availability of the precursor l-phenylalanine in the cytoplasm and thus accounts at least in part for the increase in alkaloid production.
APA, Harvard, Vancouver, ISO, and other styles
8

Li, Jing, Yi-sheng Zhong, Jie Yuan, Xun Zhu, Yong-jun Lu, Yong-cheng Lin, and Lan Liu. "A New Terminal Cyano Group-containing Benzodiazepine Alkaloid from the Mangrove Endophytic Fungus Penicillium sp." Natural Product Communications 10, no. 9 (September 2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000916.

Full text
Abstract:
A new benzodiazepine alkaloid containing terminal cyano group has been isolated from a mangrove endophytic fungus, Penicillium 299#. Structure elucidation was determined by 1D and 2D NMR spectroscopy and the absolute configuration was determined by electronic circular dichroism (ECD). The new compound showed no cytotoxic activities in vitro against human cancer lines MDA-MB-435, HepG2, HCT-116, and Calu-3.
APA, Harvard, Vancouver, ISO, and other styles
9

Sorra, Kumaraswamy, K. Mukkanti, and Srinivas Pusuluri. "Palladium catalyzed synthesis of quinazolino [1,4] benzodiazepine alkaloids and analogous." Tetrahedron 68, no. 7 (February 2012): 2001–6. http://dx.doi.org/10.1016/j.tet.2011.12.032.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Witt, F. Anette, and Jan Bergman. "Oxygen analogues of the benzodiazepine alkaloids sclerotigenin and circumdatin F." Journal of Heterocyclic Chemistry 39, no. 2 (March 2002): 351–55. http://dx.doi.org/10.1002/jhet.5570390218.

Full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "Alkaloider. Alkaloids Alkaloids Benzodiazepines Benzodiazepines"

1

Witt, Anette. "Synthetic development towards benzodiazepine alkaloids : total synthesis of circumdatin F and C /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-077-6/.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Lai, Chi-Yuh, and 賴奇裕. "Total Synthesis of Fused Benzodiazepine and Quinazolinone Alkaloids: Circumdatin F, Ent-Fumiquinazoline Gand Their Analogs." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/15537648530706358972.

Full text
Abstract:
碩士
國立中正大學
化學所
95
Ent-fumiquinazoline G and its analogs contain unique structural motifs of quinazolinone and diketopiperazin-like skeletons. The key steps involved the intramolecular dehydration of a tripeptide derivative using triphenylphosphine, iodine, and DIEA and a final cyclization-upon-deprotection leading to the establishment of the desired products. Sixteen fumiquinazoline analogs were successfully prepared in our laboratory, the results reveal that piperazine motif of compounds having two side chains required longer reaction time than those having only one stereogenic center. In addition, the overall isolated yields are lower for those having two side chains. Circumdatin F and its analogspossess 3H-quninazolin-4-one as well as a 1,4-benzodiazepin-5-one. We have successfully developed the synthesis of circumdatin F and its analogs in our laboratory. The results suggest that much longer reaction time is required in the final cyclization step for amino acids having stereochemically hindred side chains. Val-and Ile-derived circumdatins are of most significance in this total synthesis. Using our experimental protocol, six circumdatin analogs have been prepared for the time being with overall satisfactory isolated yields. Adopting Fmoc method evidently avoids harsh conditions that are required for the Cbz method. Moreover, the Fmoc procedure gives desired products with higher yields.
APA, Harvard, Vancouver, ISO, and other styles

Book chapters on the topic "Alkaloider. Alkaloids Alkaloids Benzodiazepines Benzodiazepines"

1

Roos, W. "Chapter 2 Benzodiazepine Alkaloids." In The Alkaloids: Chemistry and Pharmacology, 63–97. Elsevier, 1990. http://dx.doi.org/10.1016/s0099-9598(08)60164-9.

Full text
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'Alkaloider. Alkaloids Alkaloids Benzodiazepines Benzodiazepines' for particular source types:
Journal articles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography