Relevant bibliographies by topics / Alkylating agents; Chemistry; Pharmacology

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters

Academic literature on the topic 'Alkylating agents; Chemistry; Pharmacology'

Author: Grafiati
Published: 4 June 2021
Last updated: 6 February 2022

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Journal articles on the topic "Alkylating agents; Chemistry; Pharmacology"

1

More, Ghansham S., Asha B. Thomas, Sohan S. Chitlange, Rabindra K. Nanda, and Rahul L. Gajbhiye. "Nitrogen Mustards as Alkylating Agents: A Review on Chemistry, Mechanism of Action and Current USFDA Status of Drugs." Anti-Cancer Agents in Medicinal Chemistry 19, no. 9 (2019): 1080–102. http://dx.doi.org/10.2174/1871520619666190305141458.

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Background & Objective: :Nitrogen mustard derivatives form one of the major classes of anti-cancer agents in USFDA approved drugs list. These are polyfunctional alkylating agents which are distinguished by a unique mechanism of adduct formation with DNA involving cross-linking between guanine N-7 of one strand of DNA with the other. The generated cross-linking is irreversible and leads to cell apoptosis. Hence it is of great interest to explore this class of anticancer alkylating agents.Methods::An exhaustive list of reviews, research articles, patents, books, patient information leaflets, and orange book is presented and the contents related to nitrogen mustard anti-cancer agents have been reviewed. Attempts are made to present synthesis schemes in a simplified manner. The mechanism of action of the drugs and their side effects are also systematically elaborated.Results::This review provides a platform for understanding all aspects of such drugs right from synthesis to their mechanism of action and side effects, and lists USFDA approved ANDA players among alkylating anticancer agents in the current market.Conclusion: :Perusing this article, generic scientists will be able to access literature information in this domain easily to gain insight into the nitrogen mustard alkylating agents for further ANDA development. It will help the scientific and research community to continue their pursuit for the design of newer and novel heterocyclic alkylating agents of this class in the coming future.
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Obika, Satoshi, Yuji Kawada, Tetsuya Kodama, Kazuyuki Miyashita, and Takeshi Imanishi. "Synthesis and Evaluation of Novel 3,4-Epoxypiperidines as Efficient DNA Alkylating Agents." HETEROCYCLES 80, no. 2 (2010): 1249. http://dx.doi.org/10.3987/com-09-s(s)112.

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Singh, Rajesh K., Sahil Kumar, D. N. Prasad, and T. R. Bhardwaj. "Therapeutic journery of nitrogen mustard as alkylating anticancer agents: Historic to future perspectives." European Journal of Medicinal Chemistry 151 (May 2018): 401–33. http://dx.doi.org/10.1016/j.ejmech.2018.04.001.

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Wakselman, M., I. Cerutti, and C. Chany. "Nitrobenzyl esters as potential conjugated alkylating and differentiation promoting agents: antitumor effect in vivo." European Journal of Medicinal Chemistry 25, no. 6 (1990): 519–26. http://dx.doi.org/10.1016/0223-5234(90)90146-t.

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Iglesias-Guerra, Fernando, José I. Candela, Eugenia Blanco, Felipe Alcudia, and José M. Vega-Pérez. "Alkylating agents from sugars: Synthesis of chlorambucil derivatives carried by chiral glycosyl glycerols derived fromD-Glucosamine." Chirality 14, no. 2-3 (2002): 199–203. http://dx.doi.org/10.1002/chir.10061.

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Chiorcea-Paquim, Ana-Maria, and Ana Maria Oliveira-Brett. "DNA Electrochemical Biosensors for In Situ Probing of Pharmaceutical Drug Oxidative DNA Damage." Sensors 21, no. 4 (2021): 1125. http://dx.doi.org/10.3390/s21041125.

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Deoxyribonucleic acid (DNA) electrochemical biosensors are devices that incorporate immobilized DNA as a molecular recognition element on the electrode surface, and enable probing in situ the oxidative DNA damage. A wide range of DNA electrochemical biosensor analytical and biotechnological applications in pharmacology are foreseen, due to their ability to determine in situ and in real-time the DNA interaction mechanisms with pharmaceutical drugs, as well as with their degradation products, redox reaction products, and metabolites, and due to their capacity to achieve quantitative electroanalytical evaluation of the drugs, with high sensitivity, short time of analysis, and low cost. This review presents the design and applications of label-free DNA electrochemical biosensors that use DNA direct electrochemical oxidation to detect oxidative DNA damage. The DNA electrochemical biosensor development, from the viewpoint of electrochemical and atomic force microscopy (AFM) characterization, and the bottom-up immobilization of DNA nanostructures at the electrode surface, are described. Applications of DNA electrochemical biosensors that enable the label-free detection of DNA interactions with pharmaceutical compounds, such as acridine derivatives, alkaloids, alkylating agents, alkylphosphocholines, antibiotics, antimetabolites, kinase inhibitors, immunomodulatory agents, metal complexes, nucleoside analogs, and phenolic compounds, which can be used in drug analysis and drug discovery, and may lead to future screening systems, are reviewed.
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Marvania, Bhavin, Rajesh Kakadiya, Wilson Christian, et al. "The synthesis and biological evaluation of new DNA-directed alkylating agents, phenyl N-mustard-4-anilinoquinoline conjugates containing a urea linker." European Journal of Medicinal Chemistry 83 (August 2014): 695–708. http://dx.doi.org/10.1016/j.ejmech.2014.06.066.

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Musachio, John L., and John R. Lever. "Vinylstannylated alkylating agents as prosthetic groups for radioiodination of small molecules: design, synthesis, and application to iodoallyl analogs of spiperone and diprenorphine." Bioconjugate Chemistry 3, no. 2 (1992): 167–75. http://dx.doi.org/10.1021/bc00014a012.

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Farmer, P. B. "Metabolism and reactions of alkylating agents." Pharmacology & Therapeutics 35, no. 3 (1987): 301–58. http://dx.doi.org/10.1016/0163-7258(87)90099-4.

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Rockwell, Sara, Alan C. Sartorelli, Maria Tomasz, and Katherine A. Kennedy. "Cellular pharmacology of quinone bioreductive alkylating agents." Cancer and Metastasis Reviews 12, no. 2 (1993): 165–76. http://dx.doi.org/10.1007/bf00689808.

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Dissertations / Theses on the topic "Alkylating agents; Chemistry; Pharmacology"

1

Anderson, Fiona Mary. "Synthesis of novel alkylating agents for biological evaluation as anti-cancer prodrugs." Thesis, University of Glasgow, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249962.

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Loper, John T. "Synthesis of novel bis(bioreductive) alkylating agents /." The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487266011225016.

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Gullbo, Joachim. "Preclinical Development of New Alkylating Oligopeptides for Cancer Therapy." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3785.

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Harper, Marc Alan. "Synthesis and Characterization of Oxazaphospholidinone Phosphorus Mustard Derivatives." Youngstown State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1596552579697146.

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Okamoto, Akimitsu. "Design, Synthesis and Evaluation of Novel DNA Alkylating Agents Based on the Chemistry of Antibiotic Kapurimycin A[3]." Kyoto University, 1998. http://hdl.handle.net/2433/157035.

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本文データは平成22年度国立国会図書館の学位論文(博士)のデジタル化実施により作成された画像ファイルを基にpdf変換したものである<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(工学)<br>甲第7368号<br>工博第1743号<br>新制||工||1110(附属図書館)<br>UT51-98-G297<br>京都大学大学院工学研究科合成・生物化学専攻<br>(主査)教授 齋藤 烈, 教授 吉田 潤一, 教授 伊藤 嘉彦<br>学位規則第4条第1項該当
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Ramage, Lynn. "Beta2-adrenergic agents in asthma." Thesis, University of Aberdeen, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360346.

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This project postulated a clinically significant anti-inflammatory action of beta<SUB>2</SUB>-agonists, in particular of salmeterol, a beta<SUB>2</SUB>-agonist with clinically proven bronchodilator properties. This hypothesis was investigated by two distinct approaches. Firstly, phagocyte function was taken as a marker of inflammation and was investigated using a novel microtitre plate chemiluminescence assay. Phagocyte response to salbutamol and terbutaline in vitro was assessed to ensure that the microtitre plate assay was sensitive enough to detect suppression. Salmeterol was then investigated to see if its properties differed from more conventional beta<SUB>2</SUB>-agonists. The relationship between peripheral blood polymorphonuclear leukocyte and monocyte function and pulmonary function was explored in asthmatic subjects on different treatment regimes. Included in this investigation was a double blind, crossover study of the effects of inhaled salmeterol on peripheral phagocyte function in subjects with mild asthma. The hypothesis was also treated by investigating the effect of chronic dosing with salmeterol on exercise induced bronchoconstriction. Assessment of the protection offered was by comparing the fall in FEV1 following standard treadmill exercise challenge in a placebo controlled, double blind, crossover study. Neither approach yielded evidence to support the hypothesis of a clinically significant anti-inflammatory effect of beta<SUB>2</SUB>-agonists. Although suppression of phagocyte function by salbutamol, terbutaline and salmeterol was demonstrated in vitro, no evidence of modulation of phagocyte function was seen during clinical studies. Interestingly, there was evidence from the in vitro study that the action of salmeterol on phagocytes may not be totally beta-receptor mediated.
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Almaliti, Jehad S. "Natural Products-Inspired Synthesis and Biological Evaluation of Bioactive Agents." University of Toledo Health Science Campus / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=mco1384555204.

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Isah, Ambrose Ohumagho. "Clinical pharmacology of antiemetic agents : a study on prochlorperazine and metoclopramide." Thesis, University of Newcastle Upon Tyne, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308762.

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Coleston, Donna Maria. "Human psychopharmacological assessment of anti-dementia agents." Thesis, University of Leeds, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293955.

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Gorsuch, Stephen. "Synthetic approaches towards novel anti-HIV agents." Thesis, University of Reading, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265108.

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Books on the topic "Alkylating agents; Chemistry; Pharmacology"

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Thurston, David E. Chemistry and pharmacology of anticancer drugs. Taylor & Francis, 2007.

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C, Crabbe M. James, ed. Bacteria and anti-bacterical agents. Spektrum, 1996.

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I, Georg Gunda, American Chemical Society. Division of Chemical Health andSafety., American Chemical Society. Division of Medicinal Chemistry., and American Chemical Society. Division of Organic Chemistry., eds. Taxane anticancer agents: Basic science and current status : developed from symposia sponsored by the Divisions of Chemical Health and Safety, Medicinal Chemistry, and Organic Chemistry at the 207th National Meeting of the American Chemical Society, San Diego, California, March 13-18, 1994. The Society, 1995.

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Ellis, G. P., and G. B. West. Progress in medicinal chemistry. Elsevier, 1987.

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Perrine, Daniel M. The chemistry of mind-altering drugs: History, pharmacology, and cultural context. American Chemical Society, 1996.

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Avendaño, Carmen. Medicinal chemistry of anticancer drugs. Elsevier, 2008.

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International Workshop on Lantibiotics (1st 1991 Bad Honnef, Germany). Nisin and novel lantibiotics: Proceedings of the First International Workshop on Lantibiotics, April 15-18, 1991, Physikzentrum Bad Honnef, F.R.G. ESCOM, 1991.

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Marine comesceuticals: Trends and prospects. Taylor & Francis, 2012.

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Neidle, Stephen. Therapeutic applications of quadruplex nucleic acids. Elsevier/Academic Press, 2012.

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Free radicals effect on cytostatica, vitamins, hormones and phytocompounds with respect to cancer. Nova Science Publishers, 2008.

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Book chapters on the topic "Alkylating agents; Chemistry; Pharmacology"

1

Niculescu-Duvǎz, I., I. Baracu, and A. T. Balaban. "Alkylating agents." In The Chemistry of Antitumour Agents. Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-009-0397-5_3.

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Pegg, A. E. "DNA Repair and Carcinogenesis by Alkylating Agents." In Handbook of Experimental Pharmacology. Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-74778-6_5.

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Thurston, David E., and Ilona Pysz. "Antitubulin Agents." In Chemistry and Pharmacology of Anticancer Drugs, 2nd ed. CRC Press, 2021. http://dx.doi.org/10.1201/9781315374727-4.

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Thurston, David E., and Ilona Pysz. "Chemopreventive Agents." In Chemistry and Pharmacology of Anticancer Drugs, 2nd ed. CRC Press, 2021. http://dx.doi.org/10.1201/9781315374727-12.

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Hartley, J. A. "Mechanisms of DNA Sequence Selective Modifications by Alkylating Agents." In The Jerusalem Symposia on Quantum Chemistry and Biochemistry. Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-011-3728-7_33.

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Samtleben, Rainer, Tibor Hajto, Katarina Hostanska, and Hildebert Wagner. "Mistletoe lectins as immunostimulants (chemistry, pharmacology and clinic)." In Immunomodulatory Agents from Plants. Birkhäuser Basel, 1999. http://dx.doi.org/10.1007/978-3-0348-8763-2_9.

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Feakes, Debra A. "Chemistry and Pharmacology of Agents for BNCT." In Frontiers in Neutron Capture Therapy. Springer US, 2001. http://dx.doi.org/10.1007/978-1-4615-1285-1_3.

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Thurston, David E., and Ilona Pysz. "Nucleic Acids as Therapeutic Targets and Agents." In Chemistry and Pharmacology of Anticancer Drugs, 2nd ed. CRC Press, 2021. http://dx.doi.org/10.1201/9781315374727-5.

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Bukhari, Ali, and Ashkan Emadi. "Alkylating Agents." In Cancer Pharmacology. Springer Publishing Company, 2019. http://dx.doi.org/10.1891/9780826162045.0002.

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Scholar, Eric. "Alkylating Agents." In xPharm: The Comprehensive Pharmacology Reference. Elsevier, 2007. http://dx.doi.org/10.1016/b978-008055232-3.61034-7.

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