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Journal articles on the topic 'All the compounds show moderate antimicrobial activity'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Journal, Baghdad Science. "SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME (2-AMINO-5-THIOL-1, 3, 4-THIADIAZOLE DERIVATIVES." Baghdad Science Journal 4, no. 1 (2007): 89–94. http://dx.doi.org/10.21123/bsj.4.1.89-94.

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Five derivatives of thiadiazole were prepared with aldehydes and alkyl halides, compoundA: 2-amino-5-thiol-1,3,4- thiadiazole, compound B :2-(o-hydroxybenzylidine)amino-5-thiol-1,3,4-thiadiazole, compoundC: 2(2-butan-lidine)amino-5-thiol-1,3,4-thiadiazole, compound E: 2- amino-5-(2-Propanylthio)-1,3,4-thiadiazol) and compound F:2(o-chlorobenzylamino)-5-(2-propanyl thio)-1,3,4 thiadiazol. All prepared compounds were diagnosed by (IR) and (UV) Spectroscopy. All of those compounds were screened for their anti-microbial activity in vitro. The results show that most of the compounds A, B, C exhibit

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Merlani, Maia, Nanuli Nadaraia, Lela Amiranashvili, et al. "Antimicrobial Activity of Some Steroidal Hydrazones." Molecules 28, no. 3 (2023): 1167. http://dx.doi.org/10.3390/molecules28031167.

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Twelve steroid based hydrazones were in silico evaluated using computer program PASS as antimicrobial agents. The experimental evaluation revealed that all compounds have low to moderate antibacterial activity against all bacteria tested, except for B.cereus with MIC at a range of 0.37–3.00 mg/mL and MBC at 0.75–6.00 mg/mL. The most potent appeared to be compound 11 with MIC/MBC of0.75/1.5 mg/mL, respectively. The evaluation of antibacterial activity against three resistant strains MRSA, E.coli and P.aeruginosa demonstrated superior activity of compounds against MRSA compared with ampicillin,

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3

Wasan K. Damdoom and Oday Hadi Raoof Al-Jeilawi. "Synthesis, Characterization and Study Antimicrobial Activity of Isoniazid Derivatives." Iraqi Journal of Pharmaceutical Sciences 34, no. 2 (2025): 116–21. https://doi.org/10.31351/vol34iss2pp116-121.

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In this study, a series of compounds (B1-B10) containing the (OR-) bond were prepared from nucleophilic substitution reaction of the Schiff base compound containing the (OH) group with different halides (alkyl halides, benzyl halides, benzoyl halides, sulfonyl halides) using the Williamson method. The prepared compounds were identified by FTIR, 1HNMR, and 13CNMR, then their effectiveness was evaluated against positive and negative gram bacterial and fungal and compared with two standard references (Ciprofloxacin ,Clotrimazole ). Overall , some of prepared compounds showed inhibition zone again

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R., N. VANSDADIA, P. RODA K., and PAREKH HANSA. "Studies on 4-Thiazolidinones Part-IX. Preparation and Antimicrobial Activity of p,p'-Bis(2-aryl-5H/ methyl- 4-thiazolidinon-3-ylmethoxy) diphenyl Sulphones." Journal Of Indian Chemical Society Vol. 66, Feb 1989 (1989): 113–15. https://doi.org/10.5281/zenodo.6303078.

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Department of Chemistry, Saurashtra University, Rajkot-360 005 <em>Manuscript received 4 January 1988, revised 18 Apra 1988, accepted 12 October 1988</em> some new 4-thiazolidinone derivatives have been prepared hearing p.p<em>'</em>-dihydroxydiphenyl sulphone moiety. The Schiff bases from p,p<em>'</em>-bis(hydrazinocarbonylmethoxy)- diphenyl suiphone were condensed with thioglycolic and thiolactic acid and their structures established by ir and pmr spectral data. All the compounds show moderate antimicrobial activity.

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5

S., Senthil, Gopi R., and G. Darshan Raj C. "Synthesis, characterization and antimicrobial activity of some quinoline appended 1,2,3-triazoles." Journal of Indian Chemical Society Vol. 92, Jun 2015 (2015): 956–59. https://doi.org/10.5281/zenodo.5674281.

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Department of Chemistry, Government Arts College, Salem-636 007, Tamilnadu, India <em>E-mail</em> : shendils@gmail.com Department of Bio-Medicinal Research, Vidya Herbs Pvt. Ltd., Bangalore-560 106, India A series of 1,2,3-appended quinoline carboxylic acid derivatives were synthesized by pfitzinger reaction method using 1,2,3-triazole ketones and isatin. 1,3-Dipolar cycloaddition reaction between aromatic azide and acetylacetone yielded the triazole unit containing ketone functionality. The synthesized compounds were characterized by the usual spectral techniques to confirm the chemical struc

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6

R., N. VANSDADIA, P. RODA K., and PARSKH HANSA. "Studies on 4-Thiazolidinones. Part-IX. Preparation and Antimicrobial Activity of P,P′-Bis(2-aryl-5H/methyl- 4-thiazolidinon-3-ylmethoxy)diphenyl Sulphones." Journal of Indian Chemical Society Vol. 66, February 1989 (1989): 113–15. https://doi.org/10.5281/zenodo.5959094.

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Department of Chemistry, Saurashtra University, Rajkot-360 005 <strong><em>Manuscript received 4 January 1988, revised 28 April 1988, accepted 12 October 1988</em></strong> <strong>some new 4</strong><strong>-</strong><strong>thiazolidinone </strong><strong>derivatives have been prepared hearing <em>p</em>.<em>p</em>'-dihydroxydiphenyl </strong><strong>suiphone moiety. The Schiff bases from </strong><strong><em>p</em></strong><strong>,<em>p</em></strong><strong>′</strong><strong>-bis(hydrazinocarbonylmethoxy)- </strong><strong>diphenyl suiphone were condensed with thioglycolic a

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7

Ispiryan, Audrone, Vilma Atkociuniene, Natalija Makstutiene, et al. "Correlation between Antimicrobial Activity Values and Total Phenolic Content/Antioxidant Activity in Rubus idaeus L." Plants 13, no. 4 (2024): 504. http://dx.doi.org/10.3390/plants13040504.

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Plant by-products, which are discarded into the environment, are rich in valuable compounds. The aim of this research was to determine the antibacterial activity of Rubus idaeus L. morphological parts and its correlation with total phenolic content and antioxidant activity. The authors also aimed to evaluate the plant’s potential as added-value products. New aspects were revealed for further use and for making novel and natural products. The study’s results indicated that raspberry leaves, inflorescences, and fruits could effectively combat three Gram-positive bacteria. According to the findin

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Dumitrescu, Ana-Maria, Rodica SIRBU, and Anca Cristina LEPĂDATU. "Study of Antimicrobial Activity of Vegetable Alcoholic Extracts Obtained from Vinca Minor L." European Journal of Medicine and Natural Sciences 4, no. 2 (2021): 39. http://dx.doi.org/10.26417/965yje50d.

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Important natural antimicrobial compounds derived from Vinca minor L. plant contain a wide variety of secondary metabolites which are useful for brain health (increasing blood circulation in the brain, supporting brain metabolism, preventing memory loss and problems with concentration and premature aging of the cell), and externally they play a role in tissue repair and skin lesion healing. The testing of the antimicrobial activity of the alcoholic plant extracts obtained from Vinca minor plant was performed on two types of pathogenic germs: a Gram-positive strain, Staphylococcus aureus ATCC 2

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Michiren Mandou, Vanini Samiyatou, Willifred Dongmo Tekapi Tsopgni, Mohamed Foundikou Nsangou, Gervais Mouthe Happi, Alain François Kamdem Waffo, and Emmanuel Ngeufa Happi. "Antimicrobial and cytotoxic extractives from <i>Ficus sycomorus</i> L. (Moraceae)." Natural Resources for Human Health 3, no. 2 (2022): 176–88. http://dx.doi.org/10.53365/nrfhh/155330.

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Our search for antimicrobial and cytotoxic leads from <i>Ficus sycomorus</i> led to the isolation of twenty-four known compounds (<b>1</b>‒<b>24</b>) from its methanolic stem bark and root extracts. The structures of all the isolated compounds were established using their 1D- and 2D-NMR spectroscopic data while the crude extracts, some fractions and compounds were tested for their antibacterial, antifungal and cytotoxicity activities. In the antimicrobial assay, compound <b>18</b> displayed good to moderate activity with MIC values of 31.25 µg/ml

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Bouloumpasi, Elisavet, Magdalini Hatzikamari, Stamatia Christaki, et al. "Assessment of Antioxidant and Antibacterial Potential of Phenolic Extracts from Post-Distillation Solid Residues of Oregano, Rosemary, Sage, Lemon Balm, and Spearmint." Processes 12, no. 1 (2024): 140. http://dx.doi.org/10.3390/pr12010140.

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Medicinal and aromatic plants (MAPs) are potential sources of natural polyphenols. Solid residues (SRs) from the essential oil (EO) industry are produced in significant volumes and may be used as natural sources of bioactive compounds. Therefore, this work was designed to examine the antioxidant and antibacterial characteristics of phenolic extracts obtained from SRs that have remained after EO distillation. SR extracts of Greek oregano, rosemary, spearmint, lemon balm, and Greek sage were assessed for their total phenolic content (TPC), antioxidant activity, and antimicrobial activity against

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Coutinho, Isabel Duarte, Claúdia Andréa Lima Cardoso, Nilva Ré-Poppi, et al. "Gas Chromatography-Mass Spectrometry (GC-MS) and evaluation of antioxidant and antimicrobial activities of essential oil of Campomanesia adamantium (Cambess.) O. Berg (Guavira)." Brazilian Journal of Pharmaceutical Sciences 45, no. 4 (2009): 767–76. http://dx.doi.org/10.1590/s1984-82502009000400022.

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The essential oils from Campomanesia adamantium (Cambess.) O. Berg leaves, collected in the reproductive (flowering and fruit-bearing) and vegetative stages, were characterized by GC-MS (Gas Chromatography-Mass Spectrometry). A total of 95 compounds of the essential oils were identified. In the reproductive stage (flowering) the major constituents were monoterpenes (limonene, α-pinene and β-pinene) while during the vegetative stage the major constituents were the sesquiterpenes (bicyclogermacrene and globulol). The essential oil of the reproductive stage shows high antimicrobial activity again

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Tomazeli, E. C., D. M. S. Valladão, C. R. Andrighetti, M. Magalhães, L. D. Battirola, and C. Bonacorsi. "Antimicrobial and antioxidant activity of the leaves and flowers of Tabebuia aurea and Cordia glabrata." Scientific Electronic Archives 13, no. 5 (2020): 59. http://dx.doi.org/10.36560/1352020918.

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The search for new compounds of plant origin with antimicrobial activity has been the goal of many research groups, due to the increase in the number of microorganisms resistant to antimicrobials. The objective of this study was to evaluate the antimicrobial and antioxidant activity of two plant species, Tabebuia aurea (“paratudo”) and Cordia glabrata (“louro branco”), present in the state of Mato Grosso. The plant material (leaves and flowers) was extracted by maceration in 70% ethanol (Et) and polar hexane (Hex) (non-polar solvent). The determination of the antimicrobial activity was carried

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Pustahija, Fatima, Mirel Subašić, Mirnesa Mulić, and Neđad Bašić. "TOTAL PHENOLICS, ANTIOXIDATIVE AND ANTIMICROBIAL ACTIVITY OF METHANOL EXTRACTS OF BERRIES OF SYMPHORICARPOS ALBUS (L.) S.F.BLAKE, S. × CHENAULTII REHDER AND S. ORBICULATUS MOENCH." Radovi Šumarskog fakulteta Univerziteta u Sarajevu 48, no. 1 (2018): 63–77. http://dx.doi.org/10.54652/rsf.2018.v48.i1.53.

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581.19:547.56]:582.971.1 Methanol extracts obtained from the berries of three Symphoricarpos taxa (Caprifoliaceae) were used to determine their total phenols concentrations, and antioxidant and antimicrobial activities. According to our knowledge, total concentrations of phenolic compounds and antimicrobial activities for of S. × chenaultii and S. orbiculatus, as well as antioxidant activity of all three analyzed taxa are for the first time analyzed in this study. Based on obtained results, it was noticed that the highest average values of the total phenols, flavonoids and flavanols had

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Oktavia, Listiana, Evana Evana, Muhammad Ilyas, and Andria Agusta. "The Antimicrobial and Antioxidant Activity of Endophytic Fungi Extract Associated with Chlorantus officinalis Blume and Staurogyne elongata Kuntze." JKPK (Jurnal Kimia dan Pendidikan Kimia) 5, no. 2 (2020): 141. http://dx.doi.org/10.20961/jkpk.v5i2.41617.

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<p>An endophytic fungi has been widely known for a source of bioactive compounds attributed as antimicrobial and antioxidant. In this report, we investigated the antimicrobial and antioxidant activity of extract of endophytic fungi associated with two indigenous Indonesian medicinal plants, i.e., <em>Chloranthus officinalis (</em>CO)<em> </em>and <em>Staurogyne elongata</em> (SE). Ten endophytic fungi isolates were collected from barks, roots, and leaves of CO and SE host plants and were cultured into potato dextrose broth (PDB) media. After 14 days of

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15

Chekuboyina, Ravi Kiran, Koteswara Rao Pagolu, Bhaskar Rao Dadi, Sirisha Nagala, and Raghava Rao Tamanam. "Physico-chemical characterization and antimicrobial activity of Ceiba pentandra (Kapok) seed oil." Alternative Medicine Studies 2, no. 1 (2012): 9. http://dx.doi.org/10.4081/ams.2012.e9.

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Oil extracted from <em>Ceiba pentandra</em> seed was studied to explore its suitability for ethnomedical uses with a special emphasis on its physiochemical characterization, antimicrobial behavior and spectrophotometric parameters. Some of the physiochemical properties were examined and compared with those of standard oils and, in particular, any common characteristics with cotton seed oil were evaluated. Spectrophotometric analysis of oil was carried out to obtain information regarding the types, numbers and position of chromophores and auxochrome, and saturated and unsaturated co

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Gacki, Michał, Karolina Kafarska, Anna Pietrzak, Izabela Korona-Głowniak, and Wojciech M. Wolf. "Double Palindrome Water Chain in Cu(II) Theophylline Complex. Synthesis, Characterization, Biological Activity of Cu(II), Zn(II) Complexes with Theophylline." Crystals 10, no. 2 (2020): 97. http://dx.doi.org/10.3390/cryst10020097.

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Two metal complexes of theophylline were synthesized. Namely, 1 with the formula [Cu(theop)2(H2O)3]·2H2O and 2, [Zn(theop)2]∙H2O (where: theop = theophylline ion). Their properties were thoroughly investigated by the elemental analysis (EA), flame atomic absorption spectrometry (FAAS), Fourier-transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA) that were augmented by antimicrobial and antioxidant analyses. Their radical scavenging ability (RSA) is notably higher than that of a pure theophylline itself. Similarly to theophylline complexes already studied by us 3, [Mn(th

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Avagyan, Alvina, Gayane Martirosyan, Jan Brindza, et al. "Antimicrobial activity of essential oils from introduced varieties of <i>Dracocephalum moldavica</i> and <i>Hyssopus officinalis</i>." Functional Food Science - Online ISSN: 2767-3146 5, no. 6 (2025): 194–204. https://doi.org/10.31989/ffs.v5i6.1625.

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Background: Aromatic and medicinal plants are highly valued for their potential influence on functional food systems due to their content of bioactive compounds and health-promoting properties. These plants have antimicrobial and antioxidant effects. Dracocephalum moldavica and Hyssopus officinalis essential oils have notable biological activity among aromatic and medicinal plants. As the demand for natural, plant-based alternatives to synthetic food preservatives has grown, these species have gained attention for their applications as functional foods. This study investigates the antimicrobia

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Kovalyov, Volodymyr, Svitlana Oliinyk, Marina Buryak, Viktoriia Pul-Luzan, Yuliia Levachkova, and Oleksiy Yakovenko. "Study of the antimicrobial activity and technological properties of a gel with catalpa bignonioides extract and dexpanthenol." Annals of Mechnikov Institute, no. 4 (December 4, 2024): 55–60. https://doi.org/10.5281/zenodo.14274995.

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<strong>Introduction.</strong> To create and improve existing medicines for the local treatment of purulent wounds, an active search for plant substances with a pronounced antimicrobial effect is underway. At the Department of Pharmacognosy of the National University of Pharmacy, Associate Professor Demeshko O. V. obtained a dry extract of Catalpa bignonioides leaves. The chemical composition of the extract is represented by a wide range of biologically active substances and, above all, phenolic compounds, which exhibit high antimicrobial, anti-inflammatory, analgesic, diuretic and reparative

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Simon, M. Obila, M. Musyimi David, and A. Sikuku Phoebe. "Phytochemical and fungicidal activity of selected plant extracts against Phaeoisariopsis griseola of common bean." International journal of Microbiology and Mycology (IJMM) 11, no. 5 (2020): 1–11. https://doi.org/10.5281/zenodo.8434601.

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Plant extracts are effective in plant pathogens control and are now becoming popular throughout the world. <em>Allium sativum</em>, <em>Azadirachta indica</em> and <em>Tithonia diversifolia </em>extracts have been reported to exhibit antimicrobial activity against phytopathogens. The aim of this study was to phytochemically screen and determine the fungicidal activity of <em>Azadirachta indica, </em>and<em> Tithonia diversifolia</em> extracts against <em>Phaeoisariopsis griseola</em> of common bean. Phytochemical analysis of the plants and

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Mehta, Prakash, Prakash Davadra, Jalpa R. Pandya, and Hitendra S. Joshi. "Synthesis, Characterization and Antimicrobial Activity of 2-Azetidinone Derivatives of Benzimidazoles." International Letters of Chemistry, Physics and Astronomy 30 (March 2014): 81–88. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.30.81.

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Some new 2-azetidinone derivatives possessing benzimidazole nucleus were synthesized and characterized by IR, NMR and mass spectral analysis. All synthesized compounds were screened for antimicrobial activity using cup plate method. All the compounds showed moderate to good antimicrobial activity and anti fungal activity.

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Mehta, Prakash, Prakash Davadra, Jalpa R. Pandya, and Hitendra S. Joshi. "Synthesis, Characterization and Antimicrobial Activity of 2-Azetidinone Derivatives of Benzimidazoles." International Letters of Chemistry, Physics and Astronomy 30 (March 12, 2014): 81–88. http://dx.doi.org/10.56431/p-sf5m81.

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Some new 2-azetidinone derivatives possessing benzimidazole nucleus were synthesized and characterized by IR, NMR and mass spectral analysis. All synthesized compounds were screened for antimicrobial activity using cup plate method. All the compounds showed moderate to good antimicrobial activity and anti fungal activity.

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Makwana, Hitesh, and Yogesh T. Naliapara. "Synthesis, Characterization and Antimicrobial Activity of N’-Benzylidene-5-Bromothiophene-2-Carbohydrazide Derivatives." International Letters of Chemistry, Physics and Astronomy 33 (May 2014): 99–105. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.33.99.

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Some new N’-benzylidene-5-bromothiophene-2-carbohydrazide derivatives possessing thiophene nucleus were synthesized and characterized by IR, NMR and mass spectral analysis. All synthesized compounds were screened for antimicrobial activity using cup plate method. All the compounds showed moderate to good antimicrobial activity and anti fungal activity

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Makwana, Hitesh, and Yogesh T. Naliapara. "Synthesis, Characterization and Antimicrobial Activity of N’-Benzylidene-5-Bromothiophene-2-Carbohydrazide Derivatives." International Letters of Chemistry, Physics and Astronomy 33 (May 11, 2014): 99–105. http://dx.doi.org/10.56431/p-dzucwt.

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Some new N’-benzylidene-5-bromothiophene-2-carbohydrazide derivatives possessing thiophene nucleus were synthesized and characterized by IR, NMR and mass spectral analysis. All synthesized compounds were screened for antimicrobial activity using cup plate method. All the compounds showed moderate to good antimicrobial activity and anti fungal activity

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Mehta, Prakash, Prakash Davadra, Nirav Shah, and Hitendra Joshi. "Synthesis and Antimicrobial Activity of Some New Imidazolinone Derivatives Containing Benzimidazole." International Letters of Chemistry, Physics and Astronomy 29 (March 2014): 74–80. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.29.74.

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In this study some new o-benzimidazol-2'-yl-benzamido-p'-benzamido-2-phenyl-4-substituted phenyl-5-oxo-Imidazolines 3a-3j were synthesized. To synthesized target molecules we used various substituted oxazolone derivatives, synthesized from substituted benzaldehyde with hippuric acid. Substituted oxazolones 2a-2j were reacted with carbohydrazide derivative of benzimidazole 1 in presence of pyridine as base to obtained substituted imidazolinone derivatives. All synthesized compounds were characterized by IR, 1H NMR, elemental analysis and further supported by mass spectroscopy. All synthesized c

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Mehta, Prakash, Prakash Davadra, Nirav Shah, and Hitendra Joshi. "Synthesis and Antimicrobial Activity of Some New Imidazolinone Derivatives Containing Benzimidazole." International Letters of Chemistry, Physics and Astronomy 29 (March 3, 2014): 74–80. http://dx.doi.org/10.56431/p-75t0xf.

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In this study some new o-benzimidazol-2'-yl-benzamido-p'-benzamido-2-phenyl-4-substituted phenyl-5-oxo-Imidazolines 3a-3j were synthesized. To synthesized target molecules we used various substituted oxazolone derivatives, synthesized from substituted benzaldehyde with hippuric acid. Substituted oxazolones 2a-2j were reacted with carbohydrazide derivative of benzimidazole 1 in presence of pyridine as base to obtained substituted imidazolinone derivatives. All synthesized compounds were characterized by IR, 1H NMR, elemental analysis and further supported by mass spectroscopy. All synthesized c

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Singh, Harjinder, Jayant Sindhu, Jitender M. Khurana, Chetan Sharma, and Kamal R. Aneja. "A Facile Eco-Friendly One-Pot Five-Component Synthesis of Novel 1,2,3-Triazole-Linked Pentasubstituted 1,4-Dihydropyridines and their Biological and Photophysical Studies." Australian Journal of Chemistry 66, no. 9 (2013): 1088. http://dx.doi.org/10.1071/ch13217.

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An eco-friendly one-pot five-component synthesis of novel 1,2,3-triazole-linked pentasubstituted 1,4-dihydropyridines under ultrasonic and microwave irradiation in polyethylene glycol (PEG) 400 is described. All newly synthesised compounds were evaluated for antibacterial activity, antifungal activity, antioxidant activity, and photophysical properties. Antimicrobial activity was evaluated against six microbial strains. All compounds exhibited antifungal activity against Aspergillus niger and Aspergillus flavus and moderate antibacterial activity against Gram positive bacteria (Staphylococcus

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Gupta, Amit, Rajendra Singh, Pankaj K. Sonar, and Shailendra K. Saraf. "Novel 4-Thiazolidinone Derivatives as Anti-Infective Agents: Synthesis, Characterization, and Antimicrobial Evaluation." Biochemistry Research International 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/8086762.

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A series of new 4-thiazolidinone derivatives was synthesized, characterized by spectral techniques, and screened for antimicrobial activity. All the compounds were evaluated against five Gram-positive bacteria, two Gram-negative bacteria, and two fungi, at concentrations of 50, 100, 200, 400, 800, and 1600 µg/mL, respectively. Minimum inhibitory concentrations of all the compounds were also determined and were found to be in the range of 100–400 µg/mL. All the compounds showed moderate-to-good antimicrobial activity. Compounds4a[2-(4-fluoro-phenyl)-3-(4-methyl-5,6,7,8-tetrahydro-quinazolin-2-y

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Chen, Dongdong, Yu Cheng, Lele Shi, Xueting Gao, Yuhang Huang, and Zhenting Du. "Design, Synthesis, and Antimicrobial Activity of Amide Derivatives Containing Cyclopropane." Molecules 29, no. 17 (2024): 4124. http://dx.doi.org/10.3390/molecules29174124.

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As an important small organic molecule, cyclopropane is widely used in drug design. In this paper, fifty-three amide derivatives containing cyclopropane were designed and synthesized by introducing amide groups and aryl groups into cyclopropane through the active splicing method, and their antibacterial and antifungal activities were evaluated in vitro. Among them, thirty-five compounds were new compounds, and eighteen compounds were known compounds (F14, F15, F18, F20–F26, F36, and F38–F44). Bioassay results disclosed that four, three, and nine of the compounds showed moderate activity agains

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Issayeva, U. B., G. S. Akhmetova, K. D. Praliyev, et al. "Synthesis and antimicrobial activity of fluorobenzoic acid amides." Chemical Journal of Kazakhstan 78, no. 2 (2022): 80–91. http://dx.doi.org/10.51580/2022-2/2710-1185.67.

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The chemistry of organofluorine compounds, before the eyes of one generation, has turned from a small branch of organic chemistry into a large independent branch of exceptionally important theoretical and practical significance. Numerous studies have confirmed the high biological activity of a number of fluorine-containing organic compounds, as a result of which such drugs as fluoroquinolone antibiotics, risperidone, fluorophenazine, haloperidol, etc. have been created and are successfully used. Among amide derivatives, substances with antibacterial, anticonvulsant, analgesic and antifungal pr

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Bodake, Mahendra B., Ghanshyam R. Jadhav, Vijay J. Medhane, and Avinash D. Bholay. "Efficient Synthesis of Novel Thiazole Substituted Pyrrolidine Derivatives and their Antimicrobial Evaluation." Asian Journal of Chemistry 32, no. 8 (2020): 2007–12. http://dx.doi.org/10.14233/ajchem.2020.22772.

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A series of new molecules containing pyrrolidine and thiazole moiety (4a-l) were designed and synthesized. The structures of the synthesized compounds were characterized by IR, 1H NMR and mass spectral data. All the synthesized compounds were screened for their antibacterial activity against strains of bacteria as well as antifungal activity against fungal strains. Minimum inhibitory concentrations (MICs) of all the synthesized compounds were determined. The screening of title compounds revealed that most of the tested compounds showed moderate to good microbial inhibitions

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Sakhil, Abbas H., and Rasmia M. Rumez. "Synthesis, Characterization and Evaluation of Antimicrobial Activity of Few New Heterocyclic Compounds Derived from Nicotinic Acid." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 12, no. 03 (2022): 970–76. http://dx.doi.org/10.25258/ijddt.12.3.08.

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New schiff bases series (VIII) a-e and 1,3-thiazolidin-4-one derivatives (IX) a-e containing the 1,2,4-triazole and 1,3,4-thiazazole rings were synthesized and screening their biological activities. These compounds were identified via Fourier transform infrared (FT-IR) spectra, some via Proton nuclear magnetic resonance (1H-NMR) and mass spectra. The biological results indicated that all of these compounds did not reveal antibacterial effectiveness against (Escherichia coli and Klebsiella species) (G-). Some of these compounds showed moderate antibacterial activity against (Staphylococcus aure

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Malki, Fatiha, Ali Alouache, and Atika Meklat. "Synthesis of Heterocyclic Mesoionic Betaines Derivatives containing a Pyrimidine Ring for screening of their Biological Activities." Research Journal of Chemistry and Environment 28, no. 1 (2023): 43–47. http://dx.doi.org/10.25303/281rjce43047.

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In the present study, a series of mesoionic pyrimidinium betaines obtained by condensation of α- -aminopyridine or N, N’- disubstituted amidines with substituted malonic esters was tested for in vitro antimicrobial activity against two bacteria: Gram-positive Staphylococcus aureus, Gram-negative Escherichia coli and three fungi: Aspergillus carbonarius, Fusarium culmorus and Mucor ramannianus to assess their potential use as antimicrobial agents using a well diffusion. These betaines are bicyclics 3, 4 monocyclic 6 and fatty betaine type of amphoteric surfactant 7. The synthesized compounds we

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Kerur, S. S., K. R. Alagawadi, H. Zhu, and F. V. Manvi. "SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NOVEL S-SUBSTITUTED PHENACYL-1, 3, 4-TRIAZOLE-THIOL DERIVATIVES FOR ANTIMICROBIAL STUDIES." INDIAN DRUGS 49, no. 08 (2012): 14–20. http://dx.doi.org/10.53879/id.49.08.p0014.

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In the present study, synthesis and antimicrobial activity of 2,5-disubstituted triazole derivatives 5a-f are described. The structures of the newly synthesized compounds were confirmed by FTIR, 1H NMR, mass and elemental analysis. All compounds were screened for antitubercular and antibacterial activity. The results revealed that most of the compounds showed high or moderate biological activity against tested microorganisms.

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M, Bhagavaan Raju, A. Ramesh A, and A. Raghuram Rao. "Synthesis and Evaluation of 2, 3, 4, 6-Tetra-Substituted-2, 3-Dihydropyridine Derivatives as Novel Antimicrobial Agents." International Journal of Pharmaceutical Sciences and Nanotechnology 11, no. 5 (2018): 4268–74. http://dx.doi.org/10.37285/ijpsn.2018.11.5.7.

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The present study has been carried out to synthesize and screen certain heterocyclic antimicrobial compounds with clues from the biologically potent activities of heterocyclic compounds containing pyridine. With a view to synthesize some biologically active compounds, it has been felt worthwhile to study the synthesis of 2, 3, 4, 6-tetra-substituted-2,3-dihydro pyridine derivatives (7a-t). They were synthesized by the condensation of respective 2-amino-2,3-dihydropyridines with different aromatic aldehydes. 7a-t were purified and characterized by physical and spectral methods (IR, 1HNMR &

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35

B. jadhav, S., R. A. shastri, K. V. gaikwad, and S. V. gaikwad. "Synthesis and Antimicrobial Studies of Some Novel Pyrazoline and Isoxazoline Derivatives." E-Journal of Chemistry 6, s1 (2009): S183—S188. http://dx.doi.org/10.1155/2009/361564.

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A new series of 1H-3-(4’-substituted phenyl)-5-(6’’-methoxy napthaline)-2-pyrazolines (4a-e) and 1H-3-(4’-substituted phenyl)-5-(6’’-methoxynapthaline)-2-isoxazolines (5a-e) were synthesized by reacting 1-(4’-substituted phenyl)-3-(6’’-methoxynapthaline)-2-propene-1-one (3a-e) with hydrazine hydrate and hydroxylamine hydrochloride respectively. All these compounds were characterized by means of their IR,1H NMR, spectroscopic data and microanalysis. All the synthesized products were evaluated for their antimicrobial activity. All the compounds exhibited significant to moderate antimicrobial act

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36

Sadath, Ali, Raj Pachori Abhishek, Taleuzzaman Mohamad, Chandrakala, and Jamal Gilani Sadaf. "Phenyl Hydrazone Derivatives of Benzofuran: Synthesis and Their Antimicrobial Activities." Asian Journal of Chemical Sciences 2, no. 3 (2017): 1–7. https://doi.org/10.9734/AJOCS/2017/34772.

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A series of (<em>Z</em>)-1-benzo [<em>b</em>] furan-2-yl-3-(substituted phenyl) prop-2-en-1-one 1-phenylhydrazone derivatives (C<sub>1</sub>-C<sub>12</sub>) of benzofuran were synthesized with satisfactory yield and pharmacologically evaluated for their <em>in vitro </em>antimicrobial activity. All the synthesized compounds were in good agreement with elemental and spectral data. A majority of the tested compounds showed good to moderate antimicrobial activity against all tested pathogenic bacterial and fungal strains.

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Yadav, Ram Nath Prasad. "Insecticidal and Antimicrobial Activity of Triaryl Antimony(V) Derivatives." Academic Voices: A Multidisciplinary Journal 3 (March 9, 2014): 40–45. http://dx.doi.org/10.3126/av.v3i1.9983.

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This paper is devoted to the biological activity of the triaryl antimony(V) derivatives which deals with insecticidal and antimicrobial activity of tris(pentafluorophenyl)antimony(V) amides, (Rf)3SbL2 (Rf = C6F5; L = NR2: and triaryl antimony(V) carboxylates, Ar3SbL2 (Ar = C6H5, p-CH3C6H4; L = OCOR. All the compounds were found to exhibit moderate to significant biological activity against P. americana (insect), P. auriginosa, S. Aurens and K. Pneumoniae (bacteria), Synnhemp Rosette (virus), Tobacco Mosaic (Virus) and A. niger, A. flavus and E. moniliforme (Fungus). The compounds with fluoro a

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Baluja, Shipra, Sumitra Chanda, and Kalpen Chavda. "Synthesis, characterization and in vitro antimicrobial activity of cyclic imide: Isoindoline-1, 3-dione derivatives." GSC Biological and Pharmaceutical Sciences 10, no. 1 (2020): 046–58. https://doi.org/10.5281/zenodo.4280907.

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A series of new cyclic imide: isoindoline-1, 3-dione derivatives were synthesized by condensation of 2-hydrazinyl-2-oxo-N-phenylacetamide and phthalic anhydride. The characterization of synthesized compounds was done by IR, <sup>1</sup>H NMR, <sup>13</sup>C NMR and mass spectroscopy. All these synthesized compounds were tested for <em>in vitro</em> antimicrobial against various bacterial and fungal strains in N, N-dimethyl formamide and Dimethyl sulfoxide. It is observed that almost all the compounds showed moderate antimicrobial activity and N, N-dimethyl formamide is bett

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Phukhatmuen, Piyaporn, Phunrawie Promnart, Sarot Cheenpracha, Surat Laphookhieo, and Panom Winyayong. "Antimicrobial Activity of Compounds Isolated from Uvaria wrayi (King) L.L. Zhou, Y.C.F. Su & R.M.K. Saunders Leaves and Twigs." Trends in Sciences 21, no. 10 (2024): 8306. http://dx.doi.org/10.48048/tis.2024.8306.

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Antimicrobial resistance (AMR) refers to the capacity of bacteria to resist the impact of antibiotics, emerging as a significant global health concern. To discover novel antibacterial agents, the isolation and elucidation of compounds from leaf and twig extracts of Uvaria wrayi (King) L.L. Zhou, Y.C.F. Su & R.M.K. Saunders were investigated for the first time. 9 known compounds were performed and categorized as polyoxygenated cyclohexenes (1-3), seco-cyclohexenes (4), acrylamide derivatives (5,6), and aristolactam alkaloids (7-9). All isolated compounds were evaluated for their antimicrobi

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Ciric, Ana, Anastasia Karioti, Jasmina Glamoclija, Marina Sokovic, and Helen Skaltsa. "Antimicrobial activity of secondary metabolites isolated from Centaurea spruneri Boiss.& Heldr." Journal of the Serbian Chemical Society 76, no. 1 (2011): 27–34. http://dx.doi.org/10.2298/jsc100127008c.

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Two coumarins, scopoletin (1) and isoscopoletin (2), two simple phenolic acids, protocatechuic acid (3) and isovanillic acid (4) and one flavonoid, eriodictyol (5) were isolated from the aerial parts of Centaurea spruneri. The structure of the compounds was established by spectroscopic methods. The in vitro antimicrobial activity of the isolated compounds was tested against eight bacteria and eight fungal species, using a microdilution method. All compounds tested showed moderate antibacterial and antifungal activities. Their minimum inhibitory concentrations were in the range 0.655 - 2.38 ?mo

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Makwana, Hitesh, and Yogesh T. Naliapara. "Synthesis, Characterization and Biological Evaluation of 2,5-di-Substituted 1,3,4-Oxadiazole Derivatives." International Letters of Chemistry, Physics and Astronomy 34 (May 2014): 48–54. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.34.48.

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We have reported some novel 1,3,4-oxadiazole synthesized by conventional method .The reaction of 5-bromothiophene-2-carbohydrazide and different benzoic acid derivatives reflux in toluene using phosphorus oxychloride as a catalyst, yielded a series of 2,5-di-substituted 1,3,4-oxadiazole HM-2a to HM-2t. The newly synthesized 2,5-di-substituted 1,3,4-oxadiazole were purified by column chromatography and characterized by IR, Mass, 1H NMR, 13C NMR spectroscopy and elemental analysis. All synthesized compounds were screened for antimicrobial activity using cup plate method. All the compounds showed

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42

Makwana, Hitesh, and Yogesh T. Naliapara. "Synthesis, Characterization and Biological Evaluation of 2,5-di-Substituted 1,3,4-Oxadiazole Derivatives." International Letters of Chemistry, Physics and Astronomy 34 (May 30, 2014): 48–54. http://dx.doi.org/10.56431/p-4r432z.

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We have reported some novel 1,3,4-oxadiazole synthesized by conventional method .The reaction of 5-bromothiophene-2-carbohydrazide and different benzoic acid derivatives reflux in toluene using phosphorus oxychloride as a catalyst, yielded a series of 2,5-di-substituted 1,3,4-oxadiazole HM-2a to HM-2t. The newly synthesized 2,5-di-substituted 1,3,4-oxadiazole were purified by column chromatography and characterized by IR, Mass, 1H NMR, 13C NMR spectroscopy and elemental analysis. All synthesized compounds were screened for antimicrobial activity using cup plate method. All the compounds showed

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43

Kumar, K. Pushpa, Reddi Mohan Naidu Kalla, Mavallur Varalakshmi, et al. "Synthesis, spectral characterization, antimicrobial activity and docking studies against DNA Gyrase-A of new 4-chloro-3-nitrobenzene sulfonamide derivatives." Organic Communications 13, no. 4 (2020): 155–64. http://dx.doi.org/10.25135/acg.oc.90.20.11.1858.

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A series of new 4-chloro-3-nitrobenzene sulfonamide derivatives 3(a-j) were synthesized from 4-chloro-3-nitrobenzene sulfonyl chloride by reacting various amino acid esters and amines 2(a-j) in high yields. The structures of all the synthesized compounds were characterized by the IR, NMR (1H & 13C), mass and elemental analyses. Further, all the synthesized compounds were tested for the antimicrobial activity and docking studies were carried out with DNA Gyrase-A. Most of the compounds showed good to moderate antimicrobial activities and binding affinity towards DNA Gyrase-A structure.

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Zarina Arshad, Zarina Arshad, Sumayya Saied Sumayya Saied, Basharat Ali Basharat Ali та ін. "Synthesis of Nʹ-Nicotinoyl Sulfonohydrazides and their Antimicrobial Activity". Journal of the chemical society of pakistan 42, № 4 (2020): 597. http://dx.doi.org/10.52568/000662.

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Nʹ-Nicotinoyl sulfonohydrazide derivatives 3-13 were synthesized from nicotinyl hydrazide and evaluated for their antimicrobial potential against Gram positive bacterial strains (Bacillus cereus, Bacillus subtilis, Corynebacterium diphtheriae, Staphylococcus fecalis, Staphylococcus aureus, and MRSA (Methicillin-resistant Staphylococcus aureus)) and Gram negative bacterial strains (Escherichia.coli, Pseudomonas aeruginosa, Salmonella ParatyphiB, Salmonella tyhpi). Compound 13 showed outstanding antibacterial activity against Staphylococcus fecalis and compounds 7 and 13 were found to be moderat

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45

Zarina Arshad, Zarina Arshad, Sumayya Saied Sumayya Saied, Basharat Ali Basharat Ali та ін. "Synthesis of Nʹ-Nicotinoyl Sulfonohydrazides and their Antimicrobial Activity". Journal of the chemical society of pakistan 42, № 4 (2020): 597. http://dx.doi.org/10.52568/000662/jcsp/42.04.2020.

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Nʹ-Nicotinoyl sulfonohydrazide derivatives 3-13 were synthesized from nicotinyl hydrazide and evaluated for their antimicrobial potential against Gram positive bacterial strains (Bacillus cereus, Bacillus subtilis, Corynebacterium diphtheriae, Staphylococcus fecalis, Staphylococcus aureus, and MRSA (Methicillin-resistant Staphylococcus aureus)) and Gram negative bacterial strains (Escherichia.coli, Pseudomonas aeruginosa, Salmonella ParatyphiB, Salmonella tyhpi). Compound 13 showed outstanding antibacterial activity against Staphylococcus fecalis and compounds 7 and 13 were found to be moderat

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Bawakid, Nahed O., Walied M. Alarif, Hajer S. Alorfi, et al. "Antimicrobial sesquiterpenoids from Laurencia obtusa Lamouroux." Open Chemistry 15, no. 1 (2017): 219–24. http://dx.doi.org/10.1515/chem-2017-0025.

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AbstractPurification of the organic extract of Laurencia obtusa Lamouroux by column chromatography and preparative thin layer chromatography provided four new compounds: a eudesmane-type sesquiterpenoid [eudesma-4(15),11-diene-5,7-diol (1)], a cuparane-type sesquiterpenoid [10-hydroxycuparaldehyde (2)], and two nor-cuparanes [3-hydroxy-15-nor-cuparan-10β-ol (3) and 2-bromo-3-hydroxy-15-nor-cuparan-10β-ol (4)]. Structural identification was made possible by comparison of spectral data with those reported in the literature. Compounds 3 and 4 are significant as nor-cuparanes are rarely isolated f

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Shah, Nirav M., and Hitendra S. Joshi. "Synthesis and Antimicrobial Screening of some New Pyrimido[1,2-a]Benzimidazole Derivatives." International Letters of Chemistry, Physics and Astronomy 25 (January 2014): 56–60. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.25.56.

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Some new pyrimido[1,2-a]benzimidazole derivatives were synthesized by reacting 2-amino benzimidazole and chalcones in n-butanol at reflux temperature. In our present study we have used various heterocyclic chalcones derived from furfural and substituted acetophenones. All synthesized compounds were characterized by IR, 1H NMR and Mass spectroscopy. All synthesized compounds were screened for their antimicrobial activity against gram positive and gram negative bacteria which showed moderate to good activity.

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Shah, Nirav M., and Hitendra S. Joshi. "Synthesis and Antimicrobial Screening of some New Pyrimido[1,2-a]Benzimidazole Derivatives." International Letters of Chemistry, Physics and Astronomy 25 (January 10, 2014): 56–60. http://dx.doi.org/10.56431/p-zlzmo8.

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Some new pyrimido[1,2-a]benzimidazole derivatives were synthesized by reacting 2-amino benzimidazole and chalcones in n-butanol at reflux temperature. In our present study we have used various heterocyclic chalcones derived from furfural and substituted acetophenones. All synthesized compounds were characterized by IR, 1H NMR and Mass spectroscopy. All synthesized compounds were screened for their antimicrobial activity against gram positive and gram negative bacteria which showed moderate to good activity.

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49

Żbikowska, Beata, Magdalena Kotowska, Andrzej Gamian, et al. "Antimicrobial and Antiradical Activity of Extracts from Leaves of Various Cultivars of Pyrus communis and Pyrus pyrifolia." Biomolecules 15, no. 6 (2025): 821. https://doi.org/10.3390/biom15060821.

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Certain plant raw materials are rich in antioxidant and antimicrobial compounds, which are highly valued in modern medicine. These include the leaves of various species and cultivars of pears. For our research, we chose the leaves of the common pear (Pyrus communis) and Asian pear (Pyrus pyrifolia). Four different extracts were obtained from all raw materials and were investigated for their antimicrobial and antioxidant activity. The content of total phenolics and flavonoids was measured using colorimetric methods, and antiradical activity was measured using DPPH and ABTS radical probes. The a

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50

Veeranki, Krishna Chaitanya, Jalapathi Pochampally, Ravi Chander Maroju, Vishnu Thumma, and Lakshmi Satya Boddu. "1,2,3-Triazoles containing Thiazole-Piperazine Moieties: Synthesis, Biological Assessment and Molecular Docking." Asian Journal of Chemistry 35, no. 1 (2022): 125–34. http://dx.doi.org/10.14233/ajchem.2023.26904.

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A novel series of thiazole-triazole-piperazine multi hybrids was designed for antimicrobial activity and the synthetic method for this series has been developed by copper catalyzed 1,3-dipolar cycloaddition of thiazole-based azide with Boc-piperidine based alkyne in the presence of CuSO4 and sodium ascorbate. Boc deprotection followed by alkylation of piperidine moiety in hybrid derivatives was also carried out. All the target compounds were confirmed using FTIR, 1H NMR, 13C NMR and LC-MS spectral techniques. These compounds were screened for the antimicrobial activity against bacteria and fun

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