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Mochulska, O. M., and K. T. Hlushko. "Peculiarities of the clinical course of allergic dermatoses in children (literature review)." Modern pediatrics. Ukraine, no. 7(111) (November 29, 2020): 58–63. http://dx.doi.org/10.15574/sp.2020.111.58.
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The prevalence of allergic diseases is constantly growing around the world. According to WHO forecasts, most of the world's population will suffer from various allergies by 2050, at the same time any substance can be an allergen, and the XXI century will be the era of allergies. In the structure of allergic diseases in children the leading place is occupied by allergic skin lesions — allergic dermatoses, which are characterized by pronounced clinical polymorphism, acute or chronic stage with the development of concomitant pathological changes in many systems of the growing child's body. Allergic dermatoses are a large group of skin diseases, including: simple and allergic contact dermatitis, atopic dermatitis, various forms of eczema, acute and chronic allergic urticaria, Quincke's edema, multiforme exudative erythema (Stevens-Johnson syndrome), acute epidermal necrolysis (Lyell's syndrome), toxicodermias, as well as less common dermatoses, in the pathogenesis of which are leading allergic reactions. Purpose — to describe clinical criteria for the differential diagnosis of allergodermatoses in children in order to increase its effectiveness. Conclusions. Allergodermatoses in children are characterized by polymorphism of clinical manifestations, which depends on the specific nosology. There is a tendency to increase the frequency of allergic skin diseases in children, especially severe forms with recurrent course, resistant to traditional pharmacotherapy. Comprehensive detailed study of clinical manifestations of allergic dermatoses in children will contribute to the development of differential diagnostic criteria for allergic dermatoses in children, to verify accurate diagnosis and to prescribe the pathogenesis-based treatment for various allergic skin diseases in time. No conflict of interest was declared by the authors. Key words: children, allergy, allergic dermatoses, clinical criteria.
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Mochulska, O. M., and T. M. Kosovska. "Systemic therapy of allergic dermatosis in children (literature review)." Modern pediatrics. Ukraine, no. 1(113) (February 19, 2021): 62–67. http://dx.doi.org/10.15574/sp.2021.113.62.
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Allergic pathology of skin is one of the most pressing problems of modern pediatry. The most common allergic dermatoses: simple and allergic contact dermatitis, atopic dermatitis, various forms of eczema, acute and chronic allergic urticaria, Quincke's edema, toxicodermias, multiforme exudative erythema (Stevens-Johnson syndrome), acute epidermal necrolysis (Lyell's syndrome). Many aspects of systemic treatment of allergic dermatoses in children are complex and controversial. The modern strategy of treatment of allergic dermatoses in children is based on the principles of evidence-based medicine. According to the international program documents EAACI (European Academy of Allergy and Clinical Immunology), AAAAI (American Academy of Allergy, Asthma & Immunology), PRACТALL (Practical Allergology Consensus Report) treatment of allergic dermatoses consists of: environmental control to eliminate allergenic and non-allergenic factors, skin care, systemic and local pharmacotherapy. Systemic pharmacotherapy includes using drugs of the following groups: antihistamines, glucocorticosteroids, membrane's stabilizators (kromons), leukotriene receptor antagonists, anti-IgE, cytostatics, sorbents, hepatoprotectors, probiotics, vitamins and minerals, antioxidants, sedative medications, enzymes, antibacterial, antifungal and antiviral, immunomodulatory and immunosuppressive medications. Purpose — to increase information on modern possibilities of systemic therapy of allergic dermatoses in children. Conclusions. Systemic pharmacotherapy of allergic dermatoses should be etiopathogenetic and influence the systemic mechanisms of allergic inflammation, which will help control the clinical course of the disease, reduce disability, improve the life quality of patients. No conflict of interest was declared by the authors. Key words: children, allergy, allergic dermatoses, systemic therapy, internal therapy.
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Mochulska, O. M. "Features of pathogenesis of itch and anti0itch therapy in children with allergic dermatosis (literature review)." Ukrainian journal of Perinatology and Pediatrics, no. 2(86) (June 25, 2021): 57–67. http://dx.doi.org/10.15574/pp.2021.86.57.
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Allergic dermatoses are allergic skin diseases, the most common of which are: simple and allergic contact dermatitis, atopic dermatitis, various forms of eczema, acute and chronic allergic urticaria, Quincke's edema, toxicodermias, multiforme exudative erythema (Stevens–Johnson syndrome), acute epidermal necrolysis (Lyell's syndrome). The clinical course of all allergic dermatoses is accompanied by itch, although its severity varies depending on the nosology. An important focus of treatment of allergic dermatoses is to control of skin itch, as it is the leading symptom. According to the international program documents EAACI (European Academy of Allergy and Clinical Immunology), AAAAI (American Academy of Allergy, Asthma & Immunology), PRACТALL (Practical Allergology Consensus Report) in treatment of allergic dermatoses the leading place takes anti-itch therapy, which requires an individual approach and daily care of skin. Systemic anti-itch therapy includes using of the following drugs: antihistamines, glucocorticosteroids, membrane's stabilizators (kromons), leukotriene receptor antagonists, anti-IgE. External anti-itch therapy consists of local application of emollients, topical glucocorticosteroids, topical calcineurin inhibitors, topical anti-histamines, reparants and epithelializing medications. Purpose — to increase knowledge about features of etiopathogenetically-based anti-itch therapy of allergic dermatoses in children. Conclusions. Treatment of itch of allergic dermatoses is diverse, complex and multi-stage, requires an individual approach to each patient, and includes: environmental control to eliminate allergenic and non-allergenic factors, systemic and local pharmacotherapy, skin care. Modern anti-itch therapy of allergic dermatoses should be etiopathogenetic and affect on local and system mechanisms of allergic inflammation with itch, it should be differentiated according to the stage of the disease, the phase of inflammation and the severity of skin manifestations and to be based on the rational use of drugs. No conflict of interest was declared by the author. Key words: children, allergy, allergic dermatoses, itch, anti-itch therapy.
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Nguyen, Van, Lauren Simon, and Ecler Jaqua. "Allergic Dermatoses." Primary Care: Clinics in Office Practice 43, no. 3 (2016): 433–49. http://dx.doi.org/10.1016/j.pop.2016.04.011.
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Beltrani, Vincent S. "ALLERGIC DERMATOSES." Medical Clinics of North America 82, no. 5 (1998): 1105–33. http://dx.doi.org/10.1016/s0025-7125(05)70405-3.
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Mochulska, O. M., and T. M. Kosovska. "Clinical and paraclinical features of course of allergic dermatosis in children." Modern pediatrics. Ukraine, no. 8(112) (December 30, 2020): 33–39. http://dx.doi.org/10.15574/sp.2020.112.33.
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In recent years, in most countries of the world there is a significant increase in allergic skin diseases — allergodermatoses, especially in children. Allergodermatoses include: simple and allergic contact dermatitis, atopic dermatitis, various forms of eczema, acute and chronic allergic urticaria, Quincke's edema, multiforme exudative erythema (Stevens—Johnson syndrome), acute epidermal necrolysis (Lyell's syndrome), toxicodermias, and other less common dermatoses with allergic reactions in the pathogenesis. Various disorders of the morphofunctional state of the skin and immune mechanisms of pathogenesis in children with allergic dermatoses have been insufficiently studied. That is why a promising area of research is to study clinical and paraclinical features of allergic dermatoses in children for identify possible diagnostic criteria. Purpose — to improve the diagnostic of allergic dermatoses in children, to analyze clinical and paraclinical features of the course of allergic dermatoses, to study the indicators of cellular and humoral immunity, cytokine status, biomarkers of sensitization to allergens. Matherials and methods. 50 children with allergic dermatoses and 32 healthy children of the control group aged 1 to 18 years were examined. General clinical, immunological, allergic and statistical research methods were used. Results. The comprehensive study of the clinical manifestations of various allergic dermatoses in children was done. Allergic dermatoses are characterized by pronounced polymorphism of clinical manifestations, acute or chronic stage course, with the development of concomitant pathological polysystemic changes. In children with allergic dermatoses was detected disorders of the cellular immuneity with the development of an imbalance between individual subpopulations of lymphocytes: a decrease of CD3 with an increase of CD4 and a decrease of CD8, a corresponding increase of the immunoregulatory index, as well as an increase of CD20, CD19 and CD16 in the blood. Analysis of humoral immunity in children with allergic dermatoses showed dyssimmunoglobulinemia with decrease concentration of IgA, a significant increase concentration of IgE and a moderate increase concentration of IgM, IgG in the blood. Also in children with allergic dermatoses an increase concentration of circulating immune complexes and histamine in the blood was found. Conclusions. As the result of the conducted research similar immunological mechanisms in the pathogenesis of allergic skin diseases in children were established, together with etiologically significant factors and the only one mechanism for the formation of sensitization to allergens. The obtained data gave grounds to combine all allergic skin lesions in children into the one nosological group of allergic dermatoses. Dedicated clinical and paraclinical criteria of the diseases will promote to verify timely accurate diagnosis. The study was conducted in accordance with the principles of the Helsinki Declaration. The research protocol was approved by the Local Ethics Committee of the institution mentioned in the work. Informed consent of parents of children was obtained for the research. The authors were declare no conflict of interest. Key words: children, allergy, allergic dermatoses, cellular and humoral immunity, cytokine status.
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Mochulska, O. M. "External therapy of allergic dermatoses in children (literature review)." UKRAINIAN JOURNAL OF PERINATOLOGY AND PEDIATRICS, no. 4(84) (December 30, 2020): 41–47. http://dx.doi.org/10.15574/pp.2020.84.41.
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Allergic dermatoses have a special place in the structure of allergic diseases in children due to their weight. The most common allergic skin lesions: simple and allergic contact dermatitis, atopic dermatitis, various forms of eczema, acute and chronic allergic urticaria, Quincke's edema, multiforme exudative erythema (Stevens—Johnson syndrome), acute epidermal necrolysis (Lyell's syndrome), toxicodermias, as well as less common dermatoses, in the pathogenesis of which are leading allergic reactions. Despite a number of research research, the difficulties in the determining of the therapeutic approach of allergic dermatoses in children are still observed. According to the international program documents EAACI (European Academy of Allergy and Clinical Immunology), AAAAI (American Academy of Allergy, Asthma & Immunology), PRACТALL (Practical Allergology Consensus Report) in treatment of allergic dermatoses the leading place takes external therapy, which requires an individual approach and daily care of skin. External therapy consists of local application of emollients, topical glucocorticosteroids, topical calcineurin inhibitors, topical antihistamines, keratolytic, keratoplastic, reparants, epithelializing and anti-inflammatory medications, in the case of complicated clinical course of the disease — antibacterial, antifungal, antiviral medications, also with skin care. Purpose — to increase information on modern possibilities of external therapy of allergic dermatoses in children. External pharmacotherapy of allergic dermatoses should be etiopathogenetic and should affect on the mechanisms of allergic inflammation in the skin, elimination of itching, dryness,so finding ways to improve it will help to control the clinical course of the disease, to reduce disability, will promote to improve the life quality in patients. No conflict of interest was declared by the author. Key words: children, allergy, allergic dermatoses, external therapy, local therapy.
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Ranaivo, Irina Mamisoa, Fandresena Arilala Sendrasoa, Malalaniaina Andrianarison, et al. "Clinicoepidemiology of Skin Diseases in Children Seen at the University Hospital Center Morafeno, Toamasina, Madagascar." Dermatology Research and Practice 2021 (September 9, 2021): 1–6. http://dx.doi.org/10.1155/2021/6456448.
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Introduction. The child’s skin diseases are common and very diverse. Many studies concerning pediatric dermatoses have been carried out in Africa and the rest of the world. Few epidemioclinical data reflect these skin diseases in children, especially in the east coast of Madagascar. We aim to describe the pattern skin diseases among children seen at the University Hospital Center Morafeno, Toamasina, Madagascar. Patients and Methods. A retrospective study over a 3-year period from January 2017 to December 2019 was conducted in children seen in the Dermatology Department of University Hospital Center Morafeno, Toamasina, with skin diseases. Results. During the study period, 347 children out of the 1584 new patients were retained with a sex ratio of 0.86. The mean age was 6.4 years old. The main diseases identified were skin infectious diseases (43, 23%), allergic dermatoses (24.21%), and autonomous dermatosis (15.56%). Conclusion. Our study revealed the importance of infectious and allergic dermatoses in Toamasina. It is necessary to carry out simple preventive actions such as hygiene.
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Kondratyeva, Y. S., T. N. Shepileva, and E. A. Subbotin. "Topical therapy for facial allergic dermatoses." Vestnik dermatologii i venerologii 91, no. 5 (2015): 109–15. http://dx.doi.org/10.25208/0042-4609-2015-91-5-109-115.
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The research goal is to assess clinical dynamics and morphofunctional skin parameters of patients with facial allergic dermatoses on the background of combined topical therapy. Materials and methods. 45 patients with various facial allergic dermatoses in dry and sensitive skin took part in the research. The methods included anamnesis taking, poll, objective examination and assessment of morphofunctional parameters of skin, as well as estimation of life quality dynamic index (LQDI). Main results. After a course of treatment with 0,05% solution of alclometasone dipropionate inflammation of dermatosis ceased in 45 (100%) patients, itching and pains in 39 (86,7%) patients, but complaints about dryness and peeling of facial skin remained in 41 (91,1%) and 40 (88,8%) patients respectively. On the background of therapy including emollient Aflocream the above mentioned symptoms did not appear in 43 (95,6%) patients, wherein maximum effect was achieved in patients with allergic contact dermatitis - 14 (93,3%). After a course of topical therapy all patients showed statistically significant increase of epidermal moisture level, alongside with reduction of skin relief and degree of keratinization. During the assessment of LQDI a tendency to reduction of proportion of patients on whom the disease has a strong and extremely strong impact was noted in 10 patients (i.e. 22,2%), moderate influence - in 5 of them (11,45%), insignificant influence or its absence - in 30 (66,7%) people. Conclusion. Combined therapy including the use of a topical corticosteroid Afloderm and an emollient Aflocream showed good clinical efficiency in patients with facial allergic dermatoses. The efficiency is also confirmed with improvements in morphofunctional characteristics of patients’ skin on the background of therapy.
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Pariser, Robert J. "Allergic and reactive dermatoses." Postgraduate Medicine 89, no. 8 (1991): 75–85. http://dx.doi.org/10.1080/00325481.1991.11700954.
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Ndiaye, Coumba, Boubacar Ahy Diatta, Maodo Ndiaye, Khadim Diop, and Suzanne Oumou Niang. "Immuno-allergic dermatoses in the Dermatology Department of Aristide LeDantec Hospital, Dakar, Senegal: Epidemiological, clinical, and etiological patterns." Our Dermatology Online 15, Supp 1 (2024): 14–19. http://dx.doi.org/10.7241/ourd.2024s1.3.
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Background: Immuno-allergic dermatoses have been highly increasing for a decade in African settings. They are the first chief complaint of dermatological conditions in Senegal. Our objective was to describe their epidemiological, clinical, and etiological patterns. Methodology: We conducted a looking-forward descriptive study for 1 year ranging from April 2020 to April 2021 in the Dermatology Department of Aristide LeDantec Hospital in Dakar. We recruited both inpatients and outpatients. Results: Among 5633 patients received for consultation, 149 cases were pooled accounting for a prevalence of 2,6%. The mean age was 31,42 years old. Atopic dermatosis was the first immuno-allergic dermatosis representing 66,4%. They were followed by toxidermia in 16,1% of cases, contact dermatitis in 12,75% of cases, and urticaria in 4,69%. For patients with atopic dermatosis, a respiratory prick test was carried out in 14,1% of patients with a positivity in 57,1% of cases. Of the patients with urticaria and/or angioedema, the main triggering factor was drug use in 57,14% of cases. In our study, antibiotics were the first drug-related toxidermia in our patients accounting for 41,7% of cases. They were followed by herbal therapy in 29,2% of cases and paracetamol in 16,7% of cases. Conclusion: To date, immuno-allergic dermatoses constitute the first chief complaint in our structure and are by far dominated by atopic dermatitis. Automedication and herbal therapy are public health concerns. By causing toxidermia, often in their most serious patterns, they can have a vital prone-threat involvement.
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Reznichenko, Yu G., N. Yu Reznichenko, O. M. Gurja, N. Yu Onishchenko, K. O. Veretelnyk, and O. M. Petrashyna. "Effectiveness of dermatocosmetic products «Psoriaten» in the treatment of chronic allergic dermatoses: results of a clinical study." Ukrainian Journal of Dermatology, Venerology, Cosmetology, no. 4 (December 30, 2024): 39–50. https://doi.org/10.30978/ujdvk2024-4-39.
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Objective — to increase the effectiveness of the treatment of patients with chronic allergic dermatoses by using dermatocosmetic products Psoriaten in complex therapy based on the study of skin microbiocenosis, psychological state and quality of life of patients. Materials and methods. The monitoring involved 107 people, including 72 patients with chronic allergic dermatoses (38 with atopic dermatitis and 34 with true eczema), who were divided into 2 groups: the experimental group — 35 patients who used Psoriaten ointment and dermatocosmetic product Psoriaten along with standard therapy for 6 months; the comparison group — 37 patients who received only standard treatment for 6 months. The control group included 35 healthy people. All patients were examined according to existing standards. We used Biochemical and microbiological methods, evaluation of the expressiveness of chronic allergic dermatoses according to the SCORAD index, determination of the level of anxiety according to the HADS anxiety and Hamilton anxiety scales, neuroticism — according to the H. Eysenck scale, depression — according to the HADS depression hospital scale, Hamilton’s depression scale, assessment of quality of life using the Dermatology Life Quality Index (Ukrainian version of the Dermatology Life Quality Index — DLQI) and CQLS and the integral indicator of the self-assessment questionnaire. The obtained results were processed statistically using standard computer programs. Results and discussion. 3 months after the start of treatment in the experimental group, a statistically significant decrease in the SCORAD index was noted in patients with allergic dermatitis who additionally used Psoriaten, so after 6 months, a statistically significant difference in DSCORAD (%) was observed at the end of treatment between the experimental and comparison groups. This indicates a positive clinical effect of using dermatocosmetic product Psoriaten in complex chronic allergic dermatoses therapy. The effectiveness of additional use of Psoriaten in the treatment of chronic allergic dermatosis is indicated by the presence of a statistically significant difference after 6 months of therapy between the group that received only standard therapy and the group with additional use of Psoriaten in the total number of bacteria, the number of Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus hominis, Streptococcus pyogenes, Candida fungi. After 6 months from the start of treatment, patients in the group that additionally received Psoriaten had statistically significantly lower rates of anxiety, neuroticism, and depression compared to the group that received only standard therapy. The obtained results indicate a significant improvement in the quality of life of patients with chronic allergic dermatoses against the background of the use of Psoriaten and testify to the high effectiveness of its use not only in terms of the regression of clinical manifestations, but also in terms of a significant improvement in the quality of life of patients. Conclusions. The use of drugs of the Psoriaten group in the treatment of patients with chronic allergic dermatoses for 6 months has a positive effect on the normalization of the skin microbiome and the reduction of general skin insemination, reliably reduces the SCORAD indices, contributes to the reduction of anxiety, neuroticism and depression against the background of improving the clinical manifestations of the disease, which results in an improvement quality of life. The results give a reason to recommend the widespread introduction of Psoriaten products in the complex therapy of patients with chronic allergic dermatoses.
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Leino, Timo, Tuula Estlander, and Lasse Kanerva. "Occupational allergic dermatoses in hairdressers." Contact Dermatitis 38, no. 3 (1998): 166–67. http://dx.doi.org/10.1111/j.1600-0536.1998.tb05688.x.
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Teclessou, Julienne Noude, Akpé Pascaline Bougala, Koussake Kombate, Bayaki Saka, Séfako Akakpo, and Palokinam Pitche. "[Reasons of consultation in Lomé dermatology departments (Togo)]." Our Dermatology Online 15, Supp 1 (2024): 1–6. http://dx.doi.org/10.7241/ourd.2024s1.1.
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Objective: The aim of this study was to list the various dermatoses observed in consultations at dermatology departments in Lomé. Method: This was a retrospective descriptive study conducted over a 16-year period (1 January 2005 to 31 December 2020) in the public dermatology departments of Lomé. Patient files were reviewed. Pathologies were grouped into immuno-allergic, inflammatory, infectious and tumoral dermatoses, sexually transmitted infections and other dermatoses. Results: During the study period, 42523 patient files were reviewed, 2730 files (6.4%) were excluded for incomplete information. July was the month with the highest frequency of consultations (11%). The average age of patients was 26.36 +/- 16.85 years (range: 1 month to 102 years) and the sex ratio (M/F) was 0.6. The age range 0-15 years was the most represented 29%. Immuno-allergic dermatoses accounted for 40.9% of consultations, followed by inflammatory dermatoses (21.4%) and infectious dermatoses (20.7%). The top 5 causes of consultation in general were: eczema 23.5%; prurigo 9.3%; irritant dermatitis 8.9%; acne 5.5% and pruritus 4.4%. Conclusion: Our study shows a high frequency of immunoallergic dermatoses in Lomé. Dermatoses are also influenced by climate change, the country’s development and various social trends.
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Khobzei, K. M., and O. B. Tymkiv. "Efficacy of treating allergic dermatoses with the original drug of topical mometasone furoate in standard clinical practice." Ukrainian Journal of Dermatology, Venerology, Cosmetology, no. 4 (November 10, 2023): 51–57. http://dx.doi.org/10.30978/ujdvk2023-4-51.
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Skin allergic dermatoses represent a significant issue and account for one of the commonest causes for patients seeking consultations with dermatologists. The prevalence of atopic dermatitis (AD) in the general population reaches 10 % among adults and 20 % among children. Despite the significant deepening of our understanding of the complex pathogenesis of allergic dermatoses and the establishing role of many genetic and epigenetic factors in provoking exacerbations of AD or predisposition to the development of allergic contact dermatitis (ACD), topical corticosteroids remain the cornerstone treatment for flareups of these disorders.We investigated the effectiveness of the mometasone furoate 0.1 % topical cream (Elocom®) for the treatment of patients with allergic dermatoses. The study included 20 patients whose participation was determined based on clinical anamnesis and examination, diagnosed with AD (n = 13) and ACD (n = 7). The duration of treatment was from 7 to 30 days. During the study, all the 20 patients (100 %) noted a significant improvement in the skin condition, 18 (90 %) — improvement during the first days of treatment. Throughout the study, none of the patients experienced side effects linked to the use of the medication. The average value of the Dermatology Life Quality Index among patients before the start of treatment was (13.0 ± 6.83) points, after treatment — (4.8 ± 3.56) points. A decrease in the Index by an average of 8.2 points indicates a significant improvement in the patients’ quality of life. The obtained results demonstrate the high effectiveness of topical mometasone furoate in the treatment of patients with allergic dermatoses. Since these results were obtained in the process of observational research, they have significant practical value.Thus Elokom®, a topical mometasone furoate preparation, is advisable for the treatment of allergic dermatoses in routine clinical practice.
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Dvoriankova, E. V., and G. A. Shevchenko. "Peri-wound skin lesions of allergic nature." Meditsinskiy sovet = Medical Council, no. 2 (March 8, 2024): 105–10. http://dx.doi.org/10.21518/ms2024-065.
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Peri-wound dermatoses are a fairly common occurrence in clinical practice. In general, they are all allergic in nature and occur on the skin around the surface area of both primary and postoperative wounds. Peri-wound skin lesions can develop as paratraumatic eczema, simple contact or allergic dermatitis. All these dermatoses can be complicated by a secondary bacterial or mycotic infection, both exogenous and endogenous, which significantly complicates the course of the dermatitis itself and wound healing. The patient is exposed to a fairly large number of potential allergens in the course of surgical care provided at all stages: both in the pre- and postoperative period, and during the surgical intervention. Among them may be drugs and antiseptics, surgical sutures, implants, and even latex gloves of healthcare practitioners in some cases. When it comes to potential allergens, foci of chronic infection in the patient’s body, as well as secondary wound infections should be noted as a separate matter. The presence of peri-wound dermatoses is the most common cause of delayed surgical debridement, and can also become an obstacle to surgical treatment and healing of the wound surface. In addition, pre-existing paratraumatic eczema can progress to a chronic course and contribute to the further spread of the inflammatory process. Thus, peri-wound dermatoses are a pressing interdisciplinary issue. Patients with peri-wound dermatoses require a personalized selection of combination therapy and additional consultative assistance from highly specialized doctors. Fixed-dose topical glucocorticoids combined with antibiotics and antimycotics may be the drugs of choice for patients with peri-wound eczematous process, with due account for complex pathogenetic effects and ease of use. The article describes clinical cases of dermatoses developed in surgical patients.
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Tlish, M. M., Z. Yu Naatyzh, and T. G. Kuznetsova. "Violation of the skin barrier in patients with allergic dermatoses: causes, consequences, possibilities of correction." Meditsinskiy sovet = Medical Council, no. 3 (March 12, 2022): 95–100. http://dx.doi.org/10.21518/2079-701x-2022-16-3-95-100.
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The article considers the topical dermatological issue concerning the breach of the integrity of the skin’s barrier in patients with allergic dermatosis. The horny layer of the skin in such patients can be broken as a result of numerous external causes: excoriations, injuries, allergens, irritants, etc. These factors, in turn, contribute to the activation of endogenous dermal proteases and decrease in the synthesis of epidermal lipids, which leads to reduced elasticity of corneocytes, increased intercellular spaces, and facilitates access for antigenic stimulants that promote the development of inflammation. The decrease in the skin’s barrier is accompanied by the development of immune inflammation, production of pro-inflammatory cytokines that inhibit the generation of antimicrobial factors, induce hyperplasia and apoptosis of keratinocytes. The integral approach plays a leading role in the treatment of the disease due to the specifics of the pathogenesis and course of allergic dermatoses. In the practice of a dermatologist, topical glucocorticosteroids occupy an important place. With their help, it is possible to quickly cope with the symptoms of inflammation in many dermatoses.The introduction presents current literature data on the role of skin ceramides in the restoration of the epidermal barrier. It is indicated that the epidermis of patients suffering from various dermatoses is characterized by a decrease in the production and dysfunction of physiological lipids, and, therefore, is prone to an increase in the incidence of pathological skin changes. Therefore, in allergic dermatoses, it is preferable to use products containing ceramides in their composition, which reduce transepidermal moisture loss, strengthen the structures of the epidermal barrier, and allow further elimination of relapses of the disease and improve the quality of life of patients.
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Elisyutina, O. G., and O. V. Shtyrbul. "Levocetirizine in clinical practice of allergist." Russian Journal of Allergy 13, no. 3 (2016): 49–50. http://dx.doi.org/10.36691/rja381.
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Levocetirizine is an effective H1-blocker of histamine receptors in complex treatment of various allergic diseases. The article presents the literature data and own observational data on clinical efficacy and safety of levocetirizine in the treatment of allergic diseases such as allergic rhinitis, bronchial asthma, allergic dermatoses.
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Mullakhanov, Zhavlon Bakhtiyarovich. "The state of C-reactive protein in patients with allergic dermatoses." Terapevt (General Physician), no. 10 (October 1, 2021): 62–66. http://dx.doi.org/10.33920/med-12-2110-08.
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The article provides data on studying the content of C-reactive protein in blood serum in patients with allergic dermatoses, taking into account their clinical course. The results of the study showed that in patients with allergic dermatoses, an increase in the concentration of C-reactive protein is noted in 58,9 % of cases, characterized by an increase in concentration by 4.7 times compared with the indicators of the control healthy group, which indicates the progression of the inflammatory process in the body.
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Fisher, Alexander A. "Allergic Dermatoses in the Medical Profession." Immunology and Allergy Clinics of North America 9, no. 3 (1989): 535–42. http://dx.doi.org/10.1016/s0889-8561(22)00233-8.
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Perlamutrov, Y. N., and K. B. Olkhovskaya. "Treatment of itch in allergic dermatoses." Russian Journal of Allergy 11, no. 1 (2014): 69–72. http://dx.doi.org/10.36691/rja571.
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Pruritus is one of the most frequent symptoms in different skin diseases. Pathophysiology of pruritus has been insufficiently studied, but to this day it is considered that the main mediator of itch is histamine. Given the important role of histamine and the location of itch receptors in the superficial layers of the epidermis, the optimum is to use a topical antihistamine. The unique properties of dimethindene (Fenistil) provides rapid elimination of symptoms of itching and inflammation in allergic dermatoses.
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MARREN, P., F. WOJNAROWSKA, and S. POWELL. "Allergic contact dermatitis and vulvar dermatoses." British Journal of Dermatology 126, no. 1 (1992): 52–56. http://dx.doi.org/10.1111/j.1365-2133.1992.tb08403.x.
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Monakhov, K. N., and N. A. Kholodilova. "The experiment of using loratadinum in pregnant women with pruritic dermatoses." Vestnik dermatologii i venerologii 92, no. 3 (2016): 123–27. http://dx.doi.org/10.25208/0042-4609-2016-92-3-123-127.
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Cai, Xinyu, Lyudmila Smirnova, Ziyuan Ma, and Ekaterina Orlova. "Allergic contact dermatitis and associated allergic dermatoses: epidemiological, allergic, and immunological characteristics." Advances in Dermatology and Allergology 38, no. 6 (2021): 1058–64. http://dx.doi.org/10.5114/ada.2021.104692.
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Ufimceva, Marina A., Yurii M. Bochkarev, Kristina I. Nikolaeva, Evgenia P. Gurkovskaya, Ekaterina S. Мylnikova, and Oksana M. Podkorytova. "Scabies in dermatovenerologist practice: a clinical case of delayed diagnosis in a patient with chronic dermatosis. Case report." Consilium Medicum 25, no. 12 (2024): 838–43. http://dx.doi.org/10.26442/20751753.2023.12.202249.
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Despite the current approaches to diagnostics and treatment, regulatory documentation and guidelines, the diagnosis of scabies can often be delayed. The long-term scabies can mimic acute and chronic dermatoses which causes inadequate treatment. Physicians, including dermatovenerologists, misdiagnose scabies. Aim – to clarify historical aspects of scabies, present a clinical case of scabies complicated by allergic dermatitis and lymphoplasia in a patient with Darye's disease as an example of delayed diagnosis of scabies, errors in management tactics and features of treatment of scabies in a patient with chronic dermatosis.
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TAMRAZOVA, O. B. "Classics and innovations in the external therapy of chronic dermatoses." Vestnik dermatologii i venerologii 88, no. 1 (2012): 62–64. http://dx.doi.org/10.25208/vdv651.
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The article presents data from the literature on the efficiency and safety of using different topical drugs for the treatment of dermatoses, and describes methods for the efficient multistage treatment of chronic allergic dermatoses using keratoplastic agents comprising ASD (Antiseptic Dorogov’s Stimulator) (the 3rd fraction) as the active substance.
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Kutasevych, Yanina, Svetlana Dzhoraieva, Valentinа Goncharenko, Irina Maschtakova, Helen Shchogoleva та Nataliya Sobol. "STUDY OF INDICATORS OF ANTIMICROBIAL RESISTANCE IN PATIENTS WITH ALLERGODERMATOSIS, СОMPLICATED BY STAPHYLOCOCCUS INFECTION, ACCORDING TO THE RESULTS OF TESTS WITH AUTOSTRAINS". JOURNAL OF THE NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE, № 2;2021 (30 серпня 2021): 73–80. http://dx.doi.org/10.37621/10.37621/jnamsu-2021-2-1.
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Abstract. The relevance of the study is due to the lack of data on the state of nonspecific cellular immunity in studies with sera and autostrains of S. aureus isolated from patients with allergic dermatoses, which would reflect the intensity of antimicrobial immunity in patients with allergic dermatoses, aggravated by staphylococcal infection, depending on the severity of dermatosis. The aim of the study was to determine and analyze the results of antimicrobial immunity indicators in patients with atopic dermatitis and true eczema, aggravated by staphylococcal infection, using sera and autostrains of S. aureus, depending on the severity of the disease. Material and methods. It was included 107 patients with different stage of the allergic dermatoses severity and control group of 15 healthy individuals to the research . The patients were divided into 3 groups in according to the severity of cutaneous process course. There were determined the basic indices of initial stages of phagocytosis and oxydepending bactericidal activity of the phagocytes. It was conducted the immunologic examinations using the autostrains patient from the locus morbi and standard strain S. aureus ATCC for the estimation of antimicrobial immunity. Results. Evaluation of phagocytosis indices in patients with allergodermatosеs showed a correlation between the severity of the disease course and the level of inhibition of the cellular level of nonspecific immunity. According to the results of studies using autostrains S. aureus, the most significant inhibition of phagocytosis (p ≤ 0,05), compared to the values of similar indicators in the control group of healthy individuals, it was found in the groups of patients with moderate and severe atopic dermatosis (AD) course, respectively: phagocytic activity (PhА) (78,1 ± 1,4) and (72,4 ± 1,4) and (71,7 ± 0,8) %; phagocytic number___ (PhN) (5,3 ± 0,2) and (4,3 ± 0,2) and (3,5 ± 0,1) absolute number (abs. num.); phagocytic index__ (PhI) (6,8 ± 0,2) and (6,2 ± 0,2) and (4,8 ± 0,1) abs. num.; phagocytic capacity (PhC) (30,3 ± 1,0) and (26,5 ± 1,8) and (22,6 ± 0,8) ×103 microbial cell /mm3; spontaneous test of the renovation of nitroblue tetrazolium (sNBT) (42,1 ± 1,3) and (48,1 ± 1,2) and (50,6 ± 0,3) %; induction test of the renovation of nitroblue tetrazolium (іNBT) (63,4 ± 1,6) and (53,4 ± 0,8) and (51,7 ± 0,7) %. In the patients with true eczema (TE), they revealed a similar regularity of phagocytosis inhibition, most pronounced in patients with a severe disease course (p ≤ 0,05), but with a slightly smaller degree of difference between the indicator values of phagocytosis compared with the group of healthy individuals, respectively: PhА (74,8 ± 1,3) and (78,1 ± 1,4) %; PhN (4,5 ± 0,1) and (5,3 ± 0,2) abs. num.; PhI (5,9 ± 0,2) and (6,8 ± 0,9) abs. num.; sНСТ (46,0 ± 0,6) and (42,1 ± 1,3) %; іНСТ (51,8 ± 0,8) and (63,4 ± 1,6) %. Conclusions. The results of identification of phagocytosis in patients with allergodermatosеs using the standard culture of S. aureus ATCC 25923 generally reflect the described regularities of inhibition in patients of the cellular level of nonspecific immunity, but are less presentable for their identification in comparison with the autostrains. Keywords: allergic dermatoses, severity of the course, S aureus autostrains, S. aureus ATCC 25923, antimicrobial resistance.
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Faizullina, E. V., and V. V. Guryanov. "Some aspects of the epidemiology of onychomycosis." Kazan medical journal 80, no. 4 (1999): 298–99. http://dx.doi.org/10.17816/kazmj70133.
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Onychomycosis is one of the most common diseases in dermatological practice, being one of the reasons for the development of drug intolerance, allergic dermatoses, and bacterial complications. Enhancing polyvalent sensitization, it is capable of causing serious allergic changes in the body.
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Pesterev, P. N., S. M. Khlynin, Ye S. Podgornova, and V. A. Perminov. "Morbidity analysis of socially important dermatoses and their clinical examination based upon results of questionnaire of conscripts in the Tomsk region." Bulletin of Siberian Medicine 6, no. 1 (2007): 111–15. http://dx.doi.org/10.20538/1682-0363-2007-1-111-115.
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Aimed at decreasing number of conscripts having allergic dermatoses, therapeutic measures were developed directed to stop-ping main pathologic manifestations of the disease which consequently leads to improved quality of life. Diseases of the skin were decreased in the Tomsk region from 6,6 to 6,1% based upon results of call-up campaigns in 2003-2005 years. Questionnaire of 150 persons in the call-up age was performed aimed at identification of main social and clinical factors which lead to the develop-ment of allergic dermatoses. Schemes of clinical observation given in the article allowed us to perform adequate observation of pa-tients with socially important dermatoses, to stop in time acute manifestations of the disease and to decrease number of patients with the given pathology in the structure of coscripts who received delays or liberations from military service
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Kovaleva, Yu S., and O. A. Kokina. "Polycomponent drugs in the treatment of intertriginous dermatosis." Meditsinskiy sovet = Medical Council, no. 13 (August 9, 2022): 60–65. http://dx.doi.org/10.21518/2079-701x-2022-16-13-60-65.
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The most common localization of dermatoses of combined etiology are intertriginous areas. In recent years, an increase in the number of patients suffering from dermatoses of combined etiology has been recorded. The reasons for this situation can be both irrational therapy and background comorbidities in the patient, as well as a number of anatomical and physiological prerequisites for the formation and maintenance of an inflammatory infectious process with localization, namely in the area of skin folds. The article describes in detail the anatomical and physiological features of these areas, the causes of the development of dermatosis of the combined etiology of the fold area. Epidemiological and statistical data on the distribution of a combination of acute, chronic, infectious and non-infectious dermatoses, the causes and frequency of their occurrence are given. Particular attention is paid to the microbiocenosis of the skin in various dermatoses with an emphasis on intertriginous localizations. Approaches to the treatment of such conditions involve the use of combined external agents containing topical corticosteroids, antimicrobial and antifungal components. The article presents data available in the literature on the effectiveness of the use of a multicomponent preparation – Tetraderm cream (consisting of an antibiotic-aminoglycoside + tissue repair stimulant + GCS for local use + an antifungal agent – econazole nitrate) for various dermatoses localized in intertriginous areas. We present our own clinical observations of the effectiveness of the use of this polycomponent preparation Tetraderm in the treatment of patients with skin lesions of combined etiology in the area of folds in atopic dermatitis, allergic dermatitis, mycotic, staphylo-streptococcal infections occurring in combination.
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Мавлянова, Ш. З., Ж. Б. Муллаханов, Ю. А. Алимухамедова, А. И. Исмогилов, and З. С. Юнусова. "The State of Pro- and Anti-Inflammatory Cytokines in Patients with Allergic Dermatoses." Дерматовенерология Косметология, no. 1-2 (May 27, 2020): 26–34. http://dx.doi.org/10.34883/pi.2020.1.6.006.
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Введение. Аллергодерматозы занимают ведущее 4-е место среди актуальных заболеваний ВОЗ, и около 30% населения экономически развитых стран страдает этими дерматозами. Особый интерес представляет изучение факторов, способствующих хронизации процесса, частому рецидивированию аллергодерматозов. Многочисленными научными исследованиями выявлено, что в основе развития осложненных форм лежат нарушения в иммунной системе организма.Цель исследования. Оценка состояния про- и противовоспалительных цитокинов у пациентов с аллергическими заболеваниями кожи.Материалы и методы. Обследовано 160 пациентов с аллергическими заболеваниями кожи от 8 до 69 лет (79 мужчин, 81 женщина), которым проводили клинические, иммунологические и статистические исследования. Контрольную группу составили 39 здоровых лиц соответствующего возраста. По клиническим формам среди 160 пациентов с аллергодерматозом у 54 (31,6%) пациентов диагностирован атопический дерматит (АД), у 70 (40,9%) – аллергический дерматит (АлД), у 36 (21,05%) – токсикодермия.Результаты и обсуждение. Результаты исследования показали, что у пациентов отмечается повышение уровней провоспалительных цитокинов – TNF-α, IL-2, IL-6 и гиперпродукция общего IgE, что характеризовало выраженность воспалительного процесса. Методом ПЦР-исследования подтверждено наличие маркерного гена nuc St. aureus в 100% (63 культуры) случаев. Контаминанты штаммов St. aureus были выявлены у 36 пациентов с аллергическими заболеваниями кожи, что составило 57,14% случаев.Заключение. Полученные результаты исследования способствуют прогнозированию клинического течения аллергодерматозов, а также разработке новых методов терапии. Introduction. Allergodermatosis takes the leading 4th place and about 30% of the population suffers from this dermatosis. Of particular interest is the study of factors contributing to the chronicity of the process, the frequent recurrence of allergic dermatoses. Numerous scientific studies haverevealed that the development of complicated forms is based on disorders in the body’s immune system.Purpose. To assess the status of pro- and anti-inflammatory cytokines in patients with allergic skin diseases.Materials and methods. 160 patients with allergic skin diseases from 8 to 69 years old were examined (men – 79 people, women – 81), who underwent clinical, immunological and statistical studies. The control group consisted of 39 healthy individuals of the corresponding age. According to clinical forms, among 160 patients with allergic dermatosis, atopic dermatitis (AD) was diagnosed in 54 (31,6%) patients, allergic dermatitis (AL) in 70 (40,9%), and toxicoderma in 36 (21,05%).Results and discussion. The results of the study showed that patients showed an increase in the levels of pro-inflammatory cytokines – TNF-α, IL-2, IL-6 and overproduction of total IgE, which characterized the severity of the inflammatory process. Contaminants of St. aureus were detected in 36 patients with allergic skin diseases, which accounted for 57,14% of cases.Conclusion. The results of the study can provide an opportunity to determine the prognosis of the clinical course of allergic dermatosis, as well as the development of new methods of therapy.
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Soloshenko, E. M. "ABOUT DISCUSSION QUESTIONS OF DRUG DISEASE DIAGNOSTICS AS AN INTERDISCIPLINARY PROBLEM." Dermatology and Venerology, no. 3 (2020): 21–24. http://dx.doi.org/10.33743/2308-1066-2020-3-21-24.
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The objective of the study – to detect drug sensitization in patients with diffuse dermatoses and complicated allergic anamnesis and to analyze drug spectrum. Materials and methods. 195 patients with drug disease and diffuse dermatoses followed by complicated allergic anamnesis were observed. Drug sensitization was detected by ultrasonic test, agglomeration reaction of leucocytes and rate of erythrocyte sedimentation in the presence of drug. Results. There were detected 23.60% of patients with drug disease, 12.30% with eczema, 11.30% with food toxidermy, 13.80% with psoriasis, 12.80% with atopic dermatitis, 26.20% with other dermatoses. Drug sensitization was detected in 70.80% patients with eczema, 22.70% with food toxidermy, 44.40% with psoriasis, 72.0% with atopic dermatitis, 60.80% with other dermatoses. The most frequently detected sensitization was registered to such drugs as antibiotics (24.60%), cardiovascular (17.40%) and hypotensive (15.40%) medicines, local anaesthetics and analgetics (15.90%), anti-inflammatory (12.30%) medicines, vitamins (13.80%), gastrointestinal medicines (11.30%), corticosteroids (5.10%) and antihistamines (4.10%). Conclusions. 1. Drug sensitization was most frequently detected in patients with eczema, atopic dermatitis and psoriasis. 2. Drug disease was caused in patients with diffuse dermatoses by polysensitization to such drugs as antibiotics (24.60%), cardiovascular (17.40%) and hypotensive (15.40%) medicines, local anaesthetics and analgetics (15.90%), anti-inflammatory medicines (12.30%), vitamins (13.80%), gastrointestinal medicines (11.30%), corticosteroids (5.10%) and antihistamines (4.10%). 3. Drug disease is an interdisciplinary problem because it was detected to the different groups of drugs in patients with diffuse dermatoses both by dermatovenerologists and doctors of all specialties
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KUNGUROV, N. V., M. M. KOKHAN, YU V. KENIKSFEST, YE I. STUKOVA, YE B. KORYUKINA, and S. V. VEDERNIKOVA. "Different drug forms of methylprednisolone aceponate for the treatment of patients with allergic skin diseases." Vestnik dermatologii i venerologii 89, no. 5 (2013): 138–51. http://dx.doi.org/10.25208/vdv603.
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The article presents the results of the efficacy and safety assessment of the treatment of adult patients suffering from allergic dermatoses with different drug forms of methylprednisolone aceponate 0.1% (Advantan). The authors revealed high efficacy of the treatment of patients with atopic dermatitis and generalized eczema with the achievement of clinical remission and regression of the EASI index by 88.6-88.8% from the baseline level after three weeks of the drug administration; in patients with hand eczema after four weeks of treatment, and in patients with allergic dermatitis - after external treatment with methylprednisolone aceponate (MPA) 0.1% for two weeks; the patients' life quality improved after the treatment. Four weeks after the completion of the treatment, the skin of all the patients was nearly free from any eruptions while itching was negligible or absent. The efficacy of the differential administration of different drug forms of MPA 0.1% (Advantan) was demonstrated to localize eruptions in problem areas, on the skin in the area of the body and limbs, and according to particular features of clinical manifestations of dermatoses. The authors confirmed the safety of MPA 0.1% (Advantan) for the treatment of patients with allergic dermatoses as well as absence of any adverse effects in patients with AD, generalized eczema, hand eczema and allergic dermatitis within the aforesaid terms.
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Stadnikova, A. S., G. A. Novik, G. E. Bagramova, and A. S. Vorobeva. "Combination therapy for managing chronic allergic dermatoses." Meditsinskiy sovet = Medical Council, no. 2 (March 16, 2023): 105–12. http://dx.doi.org/10.21518/ms2022-040.
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Atopic dermatitis is an inflammatory skin disease that is most frequently occurred in children, but also common in adults. The disease is characterized as chronic, but only 20% of children have severe atopic dermatitis, while the other 80% achieve a longterm remission by the age of 8 and earlier. The article summarizes the main details about atopic dermatitis including statistical epidemiological and pathogenetic data, and places special emphasis on the issues of patients’ quality of life and steroidophobia. It is known that combination treatment regimens are often used in the treatment of atopic dermatitis. The article highlights approaches to the tactics of choosing topical therapy according to the European guidelines for the treatment of atopic dermatitis 2018. Despite the fact that topical calcineurin inhibitors were made available for the treatment about 15 years ago, this group of drugs take the lead in the treatment of atopic dermatitis due to a pronounced anti-inflammatory mechanism of action with a steroid-sparing effect. The review presents the main mechanisms of action of topical calcineurin inhibitors and their effect on the skin’s barrier function. Literature data on the proven efficacy and high safety profile of Tacrolimus, the very first drug from the topical calcineurin inhibitor group, are presented. In the article, the authors described examples of the successful use of Tacrolimus, which can suppress the T-lymphocyte activation and reduce the production of pro-inflammatory cytokines in patients with moderate to severe atopic dermatitis, as well as with other chronic allergic dermatoses. The use of Tacrolimus in the presented clinical cases led to a reduction of severity of subjective and objective symptoms of the inflammatory skin diseases.
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Mochulska, O. M., O. R. Boyarchuk, M. I. Kinash, O. M. Shulhai, and L. I. Dobrovolska. "Vitamin status as an assessment of vitamins A, E, D providing in children with allergic dermatosis." Modern pediatrics. Ukraine, no. 6(126) (October 29, 2022): 55–61. http://dx.doi.org/10.15574/sp.2022.126.55.
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Vitamins are a group of biologically highly active, low molecular weight organic compounds of various chemical nature, which are practically not synthesized in the body or are synthesized in insufficient quantities, mainly income with food, and are vital to ensure for the flow and regulation of metabolic processes. Vitamins A, E, D play an important role in ensuring the normal functioning of the skin and mucous membranes, adequate immune response, maintaining the body’s resistance to various adverse external factors. Purpose - to study, evaluate and analyze the vitamin status, providing of vitamins A, E, D in children with allergic dermatoses. Materials and methods. 24 children with allergic dermatoses and 32 children of the control group aged 6 to 17 years were examined. General clinical, immunological, biochemical, questionnaires and statistical research methods were used. Results. Among the examined children with isolated allergopathology such as allergodermatoses were diagnosed 10 (41.7%) children, the remaining children were with combined allergic pathology such as allergodermatoses and bronchial asthma 14 (58.3%) children. The research of the providing of vitamins A, E, D in children with allergic dermatoses based on clinical symptoms showed the presence of hypovitaminosis manifestations of vitamin A in 9 (37.5%) children, vitamin E - 8 (33.3%) children, vitamin D - 14 (58.3%) children. Examination of vitamin status in children with allergodermatoses showed a marked decrease in blood levels of vitamin A, a moderate decrease in vitamin D levels, a slight decrease in vitamin E levels compared with children in the control group (p<0.05). In general, all examined children with allergodermatoses and the control group had low levels of vitamin D, subnormal low levels of vitamin A, normal levels of vitamin E according to the recommended criteria of normal supply of vitamins A, E, D according to blood levels. Conclusions. Based on the results of the study, the need for personalized correction of the consumption of vitamins A, E, D, taking into account the composition of the diet in children with allergic dermatoses, who are on elimination hypoallergenic diets were established. The synergistic effect of three vitamins A, E, D at the level of the immune system allows to recommend such a vitamin formula both for prophylactic purposes and in the complex treatment of children with skin allergies. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of all participating institutions. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.
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Mavlyanova, Sh Z., and U. Y. Sabirov. "Modern views on the classification of allergic skin diseases." Terapevt (General Physician), no. 12 (December 17, 2020): 28–40. http://dx.doi.org/10.33920/med-12-2012-04.
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The article provides modern views on the classification of allergic skin diseases. Clinical, microbiological, and mycological studies of patients with allergic dermatoses contributed to the development of a clinical working classification of allergic skin diseases, taking into account the microbiome of the body’s biosubstrates. A clinical classification of bacterial, fungal and mixed-bacterial sensitization is proposed, taking into account the identification of opportunistic microorganisms.
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Murashkin, Nikolay N., Roman A. Ivanov, A. A. Savelova, D. V. Fedorov, L. A. Opryatin, and Wasel Ahmad. "Role of the Epidermal Barrier in the Formation of Food Allergies in Children with Genodermatosis." Pediatric pharmacology 16, no. 4 (2019): 234–40. http://dx.doi.org/10.15690/pf.v16i4.2053.
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The article analyzes the most significant genodermatoses associated with a high risk of allergic reactions that may occur in the practice of a dermatologist and pediatrician, such as ichthyosis and ichthyosiform dermatoses, Netherton syndrome and other ichthyosiform erythroderma, peeling skin syndrome, SAM syndrome, as well as congenital bullous epidermolysis. The article also describes in detail the pathogenetic aspects of transcutaneous sensitization, the development of food allergies and the listed above genodermatoses, two illustrative clinical cases are given.
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Gushchin, I. S., and I. V. Danilicheva. "EBASTINE. A REASONABLE CHOICE." Russian Journal of Allergy 14, no. 4-5 (2017): 89–97. http://dx.doi.org/10.36691/rja300.
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Data on pharmacokinetics and pharmacodynamics, efficacy and safety of ebastin, a review of clinical studies of therapy of allergic rhinitis, chronic idiopathic urticaria and other dermatoses are presented.
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Khan, Wajeeha, Shaheen Akhter, Natalie Stone, Mahbub M. U. Chowdhury, and Ruwani Katugampola. "CD09 Prevalence of contact allergy in patients with vulval dermatoses: a 10-year retrospective review." British Journal of Dermatology 191, Supplement_1 (2024): i92. http://dx.doi.org/10.1093/bjd/ljae090.188.
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Abstract Allergic contact dermatitis (ACD) is an important diagnostic consideration in the evaluation of patients presenting with vulval dermatoses. Although ACD coexisting with vulval dermatoses is uncommon, identifying and avoiding the allergens can have a positive impact on the management and quality of life of patients. The aim of this retrospective review of patch test data was to identify relevant allergens in patients presenting with vulval dermatoses in two specialist centres. Relevant data were extracted from electronic database and patch test departmental records between 2013 to 2023 from two specialist cutaneous allergy centres. Patch tests were performed in accordance with the International Contact Dermatitis Research Group and European Society of Contact Dermatitis guidelines. Patch test readings were performed on day 2 and day 4, and positive reactions were recorded. In total, 155 female patients with a mean age of 53.4 years were referred for patch testing. Vulval pruritus (37.5%) and vulval eczema (29%) were the two most common presenting complaints for patch test referral. All patients were tested to the standard and anogenital series, and some to extra series including medicaments, cosmetic, plants, acrylates, hairdressing and own products, depending on clinical history. Multiple allergens were identified including metals, topical drugs, fragrances, preservatives, cosmetic constituents and rubber additives. The most common clinically relevant allergens were fragrances (27.4%), preservatives (18.5%), textile dyes (4.5%) and medicaments (2.5%). Interestingly, 9.6% of patients were tested to the acrylate series, but none had a positive reaction. Fragrance allergy was prevalent in patients with a history of vulval lichen planus and lichen sclerosus. Numerous products were implicated in causing the dermatosis, including sanitary pads, wipes, shower gels and topical medications. Overall, 76% of patients noticed improvement after avoidance of relevant allergens. Patients with chronic vulval dermatoses are at increased risk of ACD and should be assessed for possible contact dermatitis. Patch testing is required to identify relevant contact allergens, the most common of which from our cohort include fragrances, preservatives, textile dyes and medicaments. These results are comparable with previous results reported by Woodruff and Vandeweege (Woodruff CM, Trivedi MK, Botto N, Kornik R. Allergic contact dermatitis of the vulva. Dermatitis 2018; 29: 233–43; Vandeweege S, Debaena B, Lapeere H, Verstraelen H. A systematic review of allergic and irritant contact dermatitis of the vulva: the most important allergens/irritants and the role of patch testing. Contact Dermatitis 2023; 88: 249–62). Patient education and follow-up are essential in optimizing treatment and preventing recurrence of vulval ACD.
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Smiljić, Marijana, Baroš Ninković, and Boško Trifunović. "Allergic contact dermatitis caused by dexpanthenol confirmed with open application test: A case report." Scripta Medica 53, no. 2 (2022): 170–73. http://dx.doi.org/10.5937/scriptamed53-37442.
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Topical medications and cosmetic products contain many allergens that can trigger allergic contact dermatitis. One of the most frequent ingredients is dexpanthenol (bepanthen, panthenol). A case of a 19-year-old female patient is presented, with a 2-year history of continuous episodes of contact allergic reactions with positive open application test to dexpanthenol, after other dermatoses and allergens were excluded.
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Svetlana, Dzhoraeva. "Levels of specific IgE to auto-strains of s.aureus isolated from locus morbi patients with allergodermatosis." ScienceRise: Medical Science, no. 2(35) (March 31, 2020): 23–28. https://doi.org/10.15587/2519-4798.2020.198931.
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<strong>The aim</strong>: to determine the levels of specific IgE for S. aureus autostrains isolated from locus morbi with allergic dermatoses. <strong>Research methods</strong>: the study included 81 patients who received medical care in the Department of Dermatology, State Institution “Institute of Dermatology on Venereology of the National Academy of Medical Sciences of Ukraine” in 2016-2019. The patients underwent clinical and laboratory examination, which included analysis of complaints and medical history data, assessment of the severity of the disease according to the SCORAD and EASI scales, and bacteriological and immunological studies. Examination of patients was carried out during an exacerbation of the disease. <strong>Results of the study</strong>: a correlation was established between the indicators of specific humoral immunity and the clinical course of allergic dermatoses. It was proved that in patients suffering from AD with severe and moderate disease with clinically significant SCORAD indices, IgE reactivity to СCAg auto Staph was significantly higher compared to specific IgE to СCAg reference Staph: 40,5±5,4 and 22,2±3,1 (P <0,01) and 14,9±1,02 and 11,4±1,07 (p<0,01), respectively. When summarizing the results obtained in the study of the blood sera of patients with severe and moderate IE with significant EASI indices, it was shown that the levels of anti-staphylococcal IgE to CCAg auto Staph were significantly higher when compared with serum IgE to CCAg reference Staph: 15,8±1,51 and 11, 7±0,96 (p<0,01) and 8,4±0,48 and 6,9±0,39 (P <0.02), respectively. <strong>Conclusions:</strong> given that the determination of specific and total IgE in blood serum blood pressure is included in the clinical protocol for the provision of specialized and highly specialized medical care, and allergen-specific therapy is considered as a promising treatment method, the determination of specific IgE before СCAg auto Staph can provide a personalized approach for diagnosis and treatment allergic dermatoses, weighed down by staphylococcal abnormal colonization of the skin
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Kovaleva, J. S., N. K. Zyablitskaya, M. V. Orobei, and N. K. Bishevskaya. "Combined pathogenetic therapy of allergic dermatoses in children." Meditsinskiy sovet = Medical Council, no. 8 (June 7, 2021): 28–38. http://dx.doi.org/10.21518/2079-701x-2021-8-28-38.
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Allergodermatoses make up the majority of allergic skin diseases in childhood, have a recurrent course and significantly disrupt the quality of life of patients and their families. The constant use of emollients, allowing to lengthen periods of remission and reduce the need for topical drugs, is associated with defects in the skin barrier function. Treatment with topical glucocorticosteroids (TCS) and topical calcineurin inhibitors (TCI), which are the basis of pharmacotherapy, should be carried out differentially, taking into account the localization, stage and activity of the inflammatory process, the area of the lesion, the age of the child and the multifactorial genesis of the disease. The basic principles of rational local therapy include the choice of the degree of activity of the drug, its concentration, dosage form, dosage frequency, duration of use to obtain a therapeutic effect and minimize side effects. In case of severe exacerbation and localization of inflammatory elements on the body and limbs in children, it is necessary to start treatment with class 2–3 THCS. When the process is localized on the face and other sensitive areas of the skin (neck and large folds), it is recommended to use class 7 TCS or give preference to TCI. The duration of a continuous course of TCS therapy in children depends on the severity of the exacerbation and should not exceed 2 weeks. The most effective way to reduce the course steroid load and avoid side effects is the early and correct use of TCS during an exacerbation. The advantages of TCI in comparison with TCS are the low incidence of side effects, the absence of contraindications for use on sensitive skin areas, and the possibility of longer use. The article contains Russian and foreign literature data on the use of THCS and TEC in the treatment of allegodermatosis in children and our own clinical observations of the effectiveness of the use of combination therapy: Comfoderm K cream (methylprednisolone aceponate with ceramides in the base), 0.03% tacrolimus ointment and emollient means - special cream Sensoderm with physiological lipids omega 3–6–9.
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Estlander, Tuula. "Allergic dermatoses and respiratory diseases from reactive dyes." Contact Dermatitis 18, no. 5 (1988): 290–97. http://dx.doi.org/10.1111/j.1600-0536.1988.tb02836.x.
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Zembala, Patryk, Julita Zembala, Roksana Zembala, Dominik Adamowicz, Ewa Gacoń, and Inga Łopuszyńska. "Emerging Trends in Gel Nail Allergies: Prevalence, Symptoms, and Occupational Hazards Associated with Acrylate Sensitization." Journal of Education, Health and Sport 45, no. 1 (2023): 57–75. http://dx.doi.org/10.12775/jehs.2023.45.01.004.
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Introduction and objective
 Gel nail allergies have become a growing concern in recent years, as individuals experience adverse immune reactions to the chemicals present in gel nail products. The popularity of gel nails, known for their long-lasting and durable finish compared to traditional nail polishes, has increased in the beauty industry. However, specific constituents, particularly acrylate compounds used in gel nail formulations, can trigger allergic responses in susceptible individuals.
 Abbreviated description of the state of knowledge
 Findings from the reviewed articles indicate that allergic reactions to acrylates in gel nail products can manifest in various ways, including contact dermatitis, dermatoses, and general allergic responses. Nail technicians, due to their frequent exposure to gel nail products and other potential allergens, are particularly vulnerable to occupational hazards associated with acrylate sensitization. These insights highlight the need for preventive measures to protect the health and well-being of nail technicians and promote a safer working environment.
 Summary
 This literature review addresses the emerging issue of gel nail allergies and provides valuable information regarding the prevalence and characteristics of allergic reactions to acrylates. The article underscores the significance of increasing awareness, implementing preventive measures, and effectively managing gel nail allergies. By doing so, the beauty industry can ensure a safer approach to gel nail applications, benefitting both nail technicians and consumers alike.
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Kuzina, Z. A., L. A. Anisimova, O. A. Sidorenko, S. V. Grebennikova, and V. A. Grebennikov. "An effectiveness study of Bariederm cream in combined therapy of dermatoses." Vestnik dermatologii i venerologii 90, no. 4 (2014): 89–92. http://dx.doi.org/10.25208/0042-4609-2014-90-4-89-92.
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Goal. The aim of the study is evaluation of the effectiveness of a barrier cream Bariederm in combined therapy of dermatoses. Materials and Methods. 3 groups of patients were examined: 32 patients with allergic contact dermatitis, 22 female patients with cold and wind induced dermatitis and 23 children aged 5 years and under with cutaneons mastocytosis. All of them were treated with Bariederm cream. Results. Including of Bariederm cream in combined treatment fetched to increase of clinical efficiency in treatment of dermatoses. Bariederm cream is also well tolerated.
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Sadchenko, Polina Sergeevna, and Dmitry Sergeevich , Ilyushenko. "SEX AND AGE CHARACTERISTICS OF CHILDREN WITH ATOPIC DERMATITIS AND CHANGES IN THE COMPOSITION OF INTESTINAL BIOCENOSIS." Scientific medical Bulletin of Ugra 40, no. 2 (2024): 77–79. https://doi.org/10.25017/2306-1367-2024-40-8-77-79.
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Due to the obvious deterioration of the environmental situation throughout the world, an increasing commitment to replacing natural food components with synthetic one, increasing in the proportion of comorbid pathologies per capita, the development of allergic dermatoses, including atopic dermatitis, is stimulated.
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Krasavina, Eugenia K., Elena N. Kryuchkova, and Irina V. Yatcyna. "Prevention of occupational allergodermatoses using pathogenetically based techniques." HEALTH CARE OF THE RUSSIAN FEDERATION 68, no. 1 (2024): 52–58. http://dx.doi.org/10.47470/0044-197x-2024-68-1-52-58.
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Introduction. Currently, occupational skin diseases remain one of the important medical problems. In this regard, the search for new modern, promising methods for the prevention and treatment of skin diseases is relevant.
 The purpose of the study is to evaluate the effectiveness of treatment and preventive measures among industrial workers with occupational allergic dermatoses.
 Materials and methods. Two groups of patients with occupational allergic dermatoses (seventy seven cases) were examined and treated. In the control group (37 people), only traditional treatment was carried out; in the main group (40 people), the complex of treatment measures, in addition to conventional therapy, included the procedure of intravenous laser blood irradiation (ILBI). Biochemical and immunological studies were carried out using standard and unified methods.
 Results. The use of ILBI in patients with occupational dermatoses had a positive effect on the state of cellular and humoral immunity: the number of CD3+ and CD4+ lymphocytes increased by 1.2–1.5 times, the CD4+/CD8+ immunoregulatory index normalized, the content of B cells in the bloodstream decreased, and levels of immunoglobulins IgG, IgE up to 1.6 times and inflammatory mediators (interleukin -10, -4, 
 tumour necrosis factor-α) by 1.5–2.3 times. There was a 1.3-fold decrease in the content of ceruloplasmin, a protein in the acute phase 
 of inflammation, and a 1.3–1.4-fold increase in the activity of catalase and neutrophil myeloperoxidase. A more rapid regression of rashes, 
 a decrease in erythema, and the disappearance of itching was noted in the main group. The duration of the relapse-free period in this group is 1.9 times longer than in the control group.
 Limitation: study of the effectiveness of laser therapy in the treatment of patients with occupational allergic dermatoses according to clinical and laboratory parameters.
 Conclusion. The ILBI technique has shown its effectiveness and positive impact on the pathogenetic links in the development of occupational skin pathology, in comparison with traditional drug treatment. As a result, it can be used for immunorehabilitation, prevention, and treatment of this pathology.
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Abdullaev, Davlat Mukumovich, Moxinur Iskandarovna Kamolova, and Xasan Davlatovich Abdullaev. "ASSESSMENT OF THE EFFECTIVENESS OF TOPICAL TREATMENT IN PEDIATRIC PATIENTS WITH ALLERGIC SKIN DISORDERS." Modern Scientific Research International Scientific Journal 2, no. 2 (2024): 266–71. https://doi.org/10.5281/zenodo.10702888.
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<strong> </strong>the scientific search for new technologies for the restorative treatment of patients with itchy dermatoses is associated with their etiopathogenetic factors that have not yet been sufficiently studied, determining the polymorphism of clinical manifestations of this pathology, where domestic and foreign researchers include contact dermatitis (L 23), eczema (L 20.8), prurigo (L 28.1, i.e. nodular pruritus; L 28.2, i.e. papular urticaria); allergodermatitis caused by substances taken orally, as well as other nosological forms of dermatoses, united by a single category of diseases of the XII class according to the ICD-X. The problem of innovation of existing standard approaches is actualized by the fact that the level of allergization of various social groups of the population "is in direct correlation with the increasing environmental pollution of the environment. This not only makes the clinical picture of the course of itchy dermatoses heavier, but also provokes their recurrent nature, lengthening the period of disability of patients with this skin pathology, and in 9-11% leading to disability.
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Estlander, Tuula, Lasse Kanerva, and Riitta Jolanki. "Occupational Allergic Dermatoses From Textile, Leather, and Fur Dyes." American Journal of Contact Dermatitis 1, no. 1 (1990): 13–20. http://dx.doi.org/10.1097/01634989-199003000-00005.
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Estlander, Tuula, Lasse Kanerva, and Riitta Jolanki. "Occupational Allergic Dermatoses From Textile, Leather, and Fur Dyes." Dermatitis 1, no. 1 (1990): 13–20. http://dx.doi.org/10.1097/01206501-199003000-00005.
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