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Journal articles on the topic 'Allergic response'

Author: Grafiati

Published: 4 June 2021

Last updated: 5 February 2022

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1

Martin, Lynn B., and Courtney A. C. Coon. "Photoperiod-driven variation in an allergic response is independent of allergen exposure." Canadian Journal of Zoology 90, no. 9 (September 2012): 1086–93. http://dx.doi.org/10.1139/z2012-075.

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Allergy prevalence and severity varies seasonally in humans, presumably due to intra-annual changes in allergen exposure. However, it is possible that seasonality of allergic responses is also influenced by seasonal changes in the immune system. Here, we asked whether extended exposure to different day lengths would alter allergic responses to pentadecylcatechol (PDC), an allergenic component of poison ivy ( Toxicodendron radicans (L.) Kuntze), in Siberian hamsters ( Phodopus sungorus (Pallas, 1773)), a species exhibiting extensive seasonal variation in immune functions. We found that contact

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Roger, Albert, Maria Basagana, Aina Teniente-Serra, Nathalie Depreux, Yanina Jurgens, Clara Padro, Sira Miquel, Carolina Elduque, and Eva M. Martinez-Caceres. "Immunotheraphy in Allergic Diseases." Current Pharmaceutical Design 24, no. 11 (June 27, 2018): 1174–94. http://dx.doi.org/10.2174/1381612824666180116094048.

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The prevalence of allergic diseases is increasing worldwide. It is estimated that more than 30% of the world population is now affected by one or more allergic conditions and a high proportion of this increase is in young people. The diagnosis of allergy is dependent on a history of symptoms on exposure to an allergen together with the detection of allergen-specific IgE. Accurate diagnosis of allergies opens up therapeutic options. Allergen specific immunotherapy is the only successful disease-modifying therapy for IgE-mediated allergic diseases. New therapeutic strategies have been developed

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Besedovsky, Luciana, Mona Benischke, Jörg Fischer, Amir S. Yazdi, and Jan Born. "Human sleep consolidates allergic responses conditioned to the environmental context of an allergen exposure." Proceedings of the National Academy of Sciences 117, no. 20 (May 4, 2020): 10983–88. http://dx.doi.org/10.1073/pnas.1920564117.

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Allergies are highly prevalent, and allergic responses can be triggered even in the absence of allergens due to Pavlovian conditioning to a specific cue. Here we show in humans suffering from allergic rhinitis that merely reencountering the environmental context in which an allergen was administered a week earlier is sufficient to trigger an allergic response—but only if participants had slept after allergen exposure. This context-conditioning effect was entirely absent when participants stayed awake the night after allergen exposure or were tested in a different context. Unlike in context con

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Jacquet, Alain. "Innate Immune Responses in House Dust Mite Allergy." ISRN Allergy 2013 (February 28, 2013): 1–18. http://dx.doi.org/10.1155/2013/735031.

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Sensitizations to house dust mites (HDM) trigger strong exacerbated allergen-induced inflammation of the skin and airways mucosa from atopic subjects resulting in atopic dermatitis as well as allergic rhinitis and asthma. Initially, the Th2-biased HDM allergic response was considered to be mediated only by allergen B- and T-cell epitopes to promote allergen-specific IgE production as well as IL-4, IL-5, and IL-13 to recruit inflammatory cells. But this general molecular model of HDM allergenicity must be revisited as a growing literature suggests that stimulations of innate immune activation p

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Dr. Mayank Surana, Dr. Vineeta Pande, Dr. Sharad Agarkhedkar, and Dr. Ajit Teegala. "Correlation between Total Serum Immunoglobulin E (IgE) and Absolute Eosinophil Count (AEC) in Allergic Diseases In Children." VIMS Health Science Journal 7, no. 1 (March 6, 2020): 5–9. http://dx.doi.org/10.46858/vimshsj.7102.

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Allergy, is a clinical expression of soluble factors like IgE, histamine or eosinophils found in serum or plasma of such patients. The products that are responsible for allergy are called as Allergens. Allergens normally induce IgE production which leads to type 1 hypersensitivity response on subsequent exposure to the same allergen. The target organs are mostly nose, lung, skin and gastrointestinal tract. Atopy is also considered as a triad of Atopic dermatitis, allergic rhinitis and bronchial asthma. Raised serum IgE and AEC are proven indicators of allergic phenomenon. Various studies show

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Deak, Peter E., Baksun Kim, Amina Abdul Qayum, Jaeho Shin, Girish Vitalpur, Kirsten M. Kloepfer, Matthew J. Turner, et al. "Designer covalent heterobivalent inhibitors prevent IgE-dependent responses to peanut allergen." Proceedings of the National Academy of Sciences 116, no. 18 (April 8, 2019): 8966–74. http://dx.doi.org/10.1073/pnas.1820417116.

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Allergies are a result of allergen proteins cross-linking allergen-specific IgE (sIgE) on the surface of mast cells and basophils. The diversity and complexity of allergen epitopes, and high-affinity of the sIgE–allergen interaction have impaired the development of allergen-specific inhibitors of allergic responses. This study presents a design of food allergen-specific sIgE inhibitors named covalent heterobivalent inhibitors (cHBIs) that selectively form covalent bonds to only sIgEs, thereby permanently inhibiting them. Using screening reagents termed nanoallergens, we identified two immunodo

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Simbirtsev, A. S. "Cytokines and their role in immune pathogenesis of allergy." Russian Medical Inquiry 5, no. 1 (2021): 32–37. http://dx.doi.org/10.32364/2587-6821-2021-5-1-32-37.

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Allergy is characterized by inadequate hyperimmune response to one or several antigens with the properties of allergens. A specific pattern of abnormal synthesis of some cytokines (principal molecular mediators of the initiation, development, and regulation of allergic inflammation) has an important pathogenic role in allergy. In recent years, it is generally accepted that allergic disorders are accounted for by impaired immune regulation resulting from increased imbalanced activation of allergen-specific T helper 2 cell clones. Allergic type of immune response is currently referred to as type

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Williams, Jesse W., Melissa Y. Tjota, and Anne I. Sperling. "The Contribution of Allergen-Specific IgG to the Development of Th2-Mediated Airway Inflammation." Journal of Allergy 2012 (October 21, 2012): 1–9. http://dx.doi.org/10.1155/2012/236075.

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In both human asthmatics and animal models of allergy, allergen-specific IgG can contribute to Th2-mediated allergic inflammation. Mouse models have elucidated an important role for IgG and Fc-gamma receptor (FcγR) signaling on antigen presenting cells (APC) for the induction of airway inflammation. These studies suggest a positive feedback loop between IgG produced by the adaptive B cell response and FcγR signaling on innate immune cells. Studies of IgG and FcγRs in humans with asthma or allergic lung disease have been more controversial. Some reports have identified associations between alle

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9

Lei, Dawn K., and Leslie C. Grammer. "An overview of allergens." Allergy and Asthma Proceedings 40, no. 6 (November 1, 2019): 362–65. http://dx.doi.org/10.2500/aap.2019.40.4247.

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Most allergens are proteins or glycoproteins that range in molecular weight from 5000 to 100,000 Da, although polysaccharides and low-molecular-weight substances may also be allergenic. Common allergens include pollens, fungal spores, house-dust mites, and animal epithelial materials but can also include drugs, biologic products, and insect venoms. The allergic response is dependent on the route of exposure. If the exposure is to an inhaled aeroallergen, then the allergic response will be respiratory in nature. Ingested or injected exposure gives rise to gastrointestinal, cutaneous, or anaphyl

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Gushchin, I. S. "Evolutionary background of allergic reactivity: mast cells, FcεRI, IgE - three components of the effector phase of the allergic response". Russian Journal of Allergy 15, № 4 (15 грудня 2018): 5–16. http://dx.doi.org/10.36691/rja131.

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The literature data on the evolution of the main obligatory participants in the effector phase of the IgE-mediated allergic response are presented: mast cells/basophils, immunoglobulin E, and high affinity receptor for the Fcε fragment (FcεRI). Allergic reactivity is considered as the most recent evolutionary immunologically-mediated acquisition of mammals. It is aimed at recognizing small amounts of allergen entering the body in a certain time regime, and organizing an allergen-specific inflammation that carries features of elimination function. The most biologically justified way to prevent

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Svirshchevskaya, E. V., M. A. Simonova, E. V. Matushevskaya, G. V. Fattakhova, S. V. Khlgatian, D. Yu Ryazantsev, D. B. Chudakov, and S. K. Zavriev. "Humoral response to Epstein-Barr viral infection in patients with allergies." Laboratory diagnostics, no. 1 (March 1, 2019): 57–64. http://dx.doi.org/10.24075/brsmu.2019.004.

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Type I hypersensitivity is mediated by the production of IgE antibodies in response to normally harmless substances. Debate still continues about the mechanisms underlying allergic reactions. Reduced barrier tissue function can be one of the risk factors for allergies. The aim of the present work was to compare the humoral immune response to Epstein-Barr virus in patients allergic to the A. alternata fungus or D. farinae house dust mites and healthy donors. It is known that up to 90% of the world population are infected with EBV. This infection occurs at early age when a child develops allergy

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Singh, Pramila, Mary Daniels, Darrell W. Winsett, Judy Richards, Donald Doerfler, Gary Hatch, Kenneth B. Adler, and M. Ian Gilmour. "Phenotypic comparison of allergic airway responses to house dust mite in three rat strains." American Journal of Physiology-Lung Cellular and Molecular Physiology 284, no. 4 (April 1, 2003): L588—L598. http://dx.doi.org/10.1152/ajplung.00287.2002.

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Brown Norway (BN) rats develop a robust response to antigens in the lung, characterized by a large increase in allergen-specific immune function and pulmonary eosinophilia. The objective of this study was to investigate alternative models by determining whether other rat strains could be sensitized to house dust mite (HDM) antigen and whether the allergic disease process could be worsened with repeated allergen exposure. In general, BN rats sensitized by either subcutaneous or intratracheal routes exhibited increased pulmonary allergy compared with Sprague-Dawley (SD) and Lewis (L) rats. Multi

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Jo, Juandy, Johan Garssen, Leon Knippels, and Elena Sandalova. "Role of Cellular Immunity in Cow’s Milk Allergy: Pathogenesis, Tolerance Induction, and Beyond." Mediators of Inflammation 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/249784.

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Food allergy is an aberrant immune-mediated reaction against harmless food substances, such as cow’s milk proteins. Due to its very early introduction, cow’s milk allergy is one of the earliest and most common food allergies. For this reason cow’s milk allergy can be recognized as one of the first indications of an aberrant inflammatory response in early life. Classically, cow’s milk allergy, as is true for most other allergies as well, is primarily associated with abnormal humoral immune responses, that is, elevation of specific immunoglobulin E levels. There is growing evidence indicating th

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Carlsten, Chris, Anders Blomberg, Mandy Pui, Thomas Sandstrom, Sze Wing Wong, Neil Alexis, and Jeremy Hirota. "Diesel exhaust augments allergen-induced lower airway inflammation in allergic individuals: a controlled human exposure study." Thorax 71, no. 1 (November 16, 2015): 35–44. http://dx.doi.org/10.1136/thoraxjnl-2015-207399.

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RationaleTraffic-related air pollution has been shown to augment allergy and airway disease. However, the enhancement of allergenic effects by diesel exhaust in particular is unproven in vivo in the human lung, and underlying details of this apparent synergy are poorly understood.ObjectiveTo test the hypothesis that a 2 h inhalation of diesel exhaust augments lower airway inflammation and immune cell activation following segmental allergen challenge in atopic subjects.Methods18 blinded atopic volunteers were exposed to filtered air or 300 µg PM2.5/m3 of diesel exhaust in random fashion. 1 h po

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Chen, Yuwen, Hinayah Rojas de Oliveira, Amanda B. Alvarenga, Allan P. Schinckel, Terry S. Stewart, and Luiz F. Brito. "PSI-6 Genetic Parameters for Food Allergy Responses in Divergently-selected Pig Lines." Journal of Animal Science 99, Supplement_1 (May 1, 2021): 225–26. http://dx.doi.org/10.1093/jas/skab054.370.

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Abstract Genetic selection for health and welfare-related traits is paramount in livestock breeding. Piglet allergic responses to soybean protein negatively impact animal growth and welfare. The objectives of this study were to estimate the heritability of soybean allergic responses and genetic correlations between soybean and peanut allergies (r1,2) in divergently-selected pig lines. The base population consisted of nine sire lines (primarily Yorkshire and Landrace) and two dam sources (Yorkshire × Chester White-F1 and Landrace × Yorkshire-F1). Soybean and peanut-allergic responses were measu

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Stelmaszczyk-Emmel, Anna, Anna Zawadzka-Krajewska, Eliza Głodkowska-Mrówka, and Urszula Demkow. "FoxP3 Tregs Response to Sublingual Allergen Specific Immunotherapy in Children Depends on the Manifestation of Allergy." Journal of Immunology Research 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/731381.

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Over the last decades allergic diseases has become a major health problem worldwide. The only specific treatment to date is allergen specific immunotherapy (ASIT). Although it was shown that ASIT generates allergen-tolerant T cells, detailed mechanism underlying its activity is still unclear and there is no reliable method to monitor its effectiveness. The aim of our study was to evaluate ASIT influence on the frequency of forkhead box P3 (FoxP3) Tregs in allergic children with various clinical manifestations. The relative number of FoxP3 Tregs in 32 blood samples from allergic children at bas

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Assa’ad, Amal H. "Oral food challenges." Journal of Food Allergy 2, no. 1 (September 1, 2020): 31–34. http://dx.doi.org/10.2500/jfa.2020.2.200008.

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Oral food challenge (OFC) is a procedure that is conducted most commonly by allergist/immunologists in their office or in food allergy centers to confirm a food allergy or to confirm tolerance to the food. The procedure as conducted in clinical practice is mostly open food challenge and, in research, a double-blind, placebo controlled food challenge. OFC has associated risks that can be minimized by having the challenges conducted by trained personnel who are prepared to treat allergic reactions and who have rescue medications available. However, OFCs have tremendous benefits to the patients a

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18

Raftu, Gheorghe, Geta Mitrea, Luana Andreea Macovei, and Aurel Nechita. "Chemical Additives from the Composition of Plastic Products and Other Materials in Establishing Diagnosis for Alergy Disease." Materiale Plastice 55, no. 4 (December 30, 2018): 609–12. http://dx.doi.org/10.37358/mp.18.4.5085.

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Many of the chemical additives in the plastic products, besides the possible safety problems that may arise during the production process, have negative effecty, too, on the environment and human health. Plastic is a synthetic polymer. The polymers include starch, latex and cellulose, combined with different substances and chemicals, used in various formulas, the polymer is included in the naylon. At high temperatures such as microwave oven temperature, polymers can migrate from the packaging plastic in food. In most cases, establishing the diagnosis of allergic disease is a complex and diffic

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Chung, Sangwoon, Yong Gyu Lee, Manjula Karpurapu, Joshua A. Englert, Megan N. Ballinger, Ian C. Davis, Gye Young Park, and John W. Christman. "Depletion of microRNA-451 in response to allergen exposure accentuates asthmatic inflammation by regulating Sirtuin2." American Journal of Physiology-Lung Cellular and Molecular Physiology 318, no. 5 (May 1, 2020): L921—L930. http://dx.doi.org/10.1152/ajplung.00457.2019.

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The incidence of asthma has increased from 5.5% to near 8% of the population, which is a major health concern. The hallmarks of asthma include eosinophilic airway inflammation that is associated with chronic airway remodeling. Allergic airway inflammation is characterized by a complex interplay of resident and inflammatory cells. MicroRNAs (miRNAs) are small noncoding RNAs that function as posttranscriptional modulators of gene expression. However, the role of miRNAs, specifically miR-451, in the regulation of allergic airway inflammation is unexplored. Our previous findings showed that oxidan

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Dona, Dulashi Withanage, and Cenk Suphioglu. "Egg Allergy: Diagnosis and Immunotherapy." International Journal of Molecular Sciences 21, no. 14 (July 16, 2020): 5010. http://dx.doi.org/10.3390/ijms21145010.

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Hypersensitivity or an allergy to chicken egg proteins is a predominant symptomatic condition affecting 1 in 20 children in Australia; however, an effective form of therapy has not yet been found. This occurs as the immune system of the allergic individual overreacts when in contact with egg allergens (egg proteins), triggering a complex immune response. The subsequent instantaneous inflammatory immune response is characterized by the excessive production of immunoglobulin E (IgE) antibody against the allergen, T-cell mediators and inflammation. Current allergen-specific approaches to egg alle

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Neha Sharma, Shuchi Kaushik, and Rajesh Singh Tomar. "Prediction of the allergic response of extracellular amylase producing bacteria through in-silico method." International Journal of Research in Pharmaceutical Sciences 10, no. 2 (April 14, 2019): 1185–89. http://dx.doi.org/10.26452/ijrps.v10i2.404.

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Allergies intolerance is a common problem worldwide. The major difficulties are related to the correct diagnosis of causes which is associated with amino acid sequences present in the epitope region of allergen. So there is a need to find out the factors causing allergies and allergens themselves. In the present study a bioinformatics tool is used to predict amino acid sequence and mast cell association with different integrated approaches. Internet databases for amylase producing bacteria were used in In-silico method to check the allergy for microorganism producing the extracellular enzyme.

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Nair, Bindukumar, John C. Wheeler, Donald E. Sykes, Paula Brown, Jessica L. Reynolds, Ravikumar Aalinkeel, Supriya D. Mahajan, and Stanley A. Schwartz. "Proteomic Approach to Evaluate Mechanisms That Contribute to Food Allergenicity: Comparative 2D-DIGE Analysis of Radioallergosorbent Test Positive and Negative Patients." International Journal of Proteomics 2011 (September 19, 2011): 1–13. http://dx.doi.org/10.1155/2011/673618.

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Proteomic profiles of RAST+ subjects with severe food allergies and RAST− subjects were compared using 2D-DIGE analysis to obtain candidate biomarkers specific to food allergies. Our analysis highlighted 52 proteins that were differentially expressed between the RAST+ and RAST− groups of which 37 were successfully identified that include chondroitin sulfates, zinc finger proteins, C-type lectins, retinoic acid binding proteins, heat shock proteins, myosin, cytokines, mast cell expressed proteins, and MAP kinases. Biological network analysis tool Metacore revealed that most of these regulated p

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Cardoso, Cristina R., Pauline R. Provinciatto, Dannielle F. Godoi, Beatriz R. Ferreira, Gerlinde Teixeira, Marcos A. Rossi, Fernando Q. Cunha, and João S. Silva. "IL-4 regulates susceptibility to intestinal inflammation in murine food allergy." American Journal of Physiology-Gastrointestinal and Liver Physiology 296, no. 3 (March 2009): G593—G600. http://dx.doi.org/10.1152/ajpgi.90431.2008.

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Allergies involve a state of immediate hypersensitivity to antigens, including food proteins. The mechanism underlying the initiation and development of allergic responses involves IL-4 that directly induces the differentiation of committed effector Th2 lymphocytes. Although it is clear that Th2 responses play a pivotal role in the development of allergic responses, it remains unclear which mechanisms are involved in the development of the intestinal damages observed in food allergy. Accordingly, this work aimed to study the role of Th2/IL-4-dependent responses in the development of food aller

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Lew, D. Betty, Kim S. LeMessurier, Maneesha Palipane, Yanyan Lin, and Amali E. Samarasinghe. "Saccharomyces cerevisiae-Derived Mannan Does Not Alter Immune Responses to Aspergillus Allergens." BioMed Research International 2018 (2018): 1–9. http://dx.doi.org/10.1155/2018/3298378.

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Severe asthma with fungal sensitization predominates in the population suffering from allergic asthma, to which there is no cure. While corticosteroids are the mainstay in current treatment, other means of controlling inflammation may be beneficial. Herein, we hypothesized that mannan from Saccharomyces cerevisiae would dampen the characteristics of fungal allergic asthma by altering the pulmonary immune responses. Using wild-type and transgenic mice expressing the human mannose receptor on smooth muscle cells, we explored the outcome of mannan administration during allergen exposure on the pa

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Kitaoka, Momoko, Wei Xiao, Qingliang Kong, Yoshiro Tahara, Noriho Kamiya, and Masahiro Goto. "A Solid-in-Oil Nanodispersion System for Transcutaneous Immunotherapy of Cow’s Milk Allergies." Pharmaceutics 12, no. 3 (February 27, 2020): 205. http://dx.doi.org/10.3390/pharmaceutics12030205.

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An allergy to cow’s milk proteins is the most common food allergy in infants and toddlers. Conventional oral immunotherapy for cow’s milk allergies requires hospital admission due to the risk of severe allergic reactions, including anaphylaxis. Therefore, a simpler and safer immunotherapeutic method is desirable. We examined transcutaneous immunotherapy with a solid-in-oil (S/O) system. In the S/O system, nano-sized particles of proteins are dispersed in an oil-vehicle with the assistance of nonionic surfactants. In the present study, the S/O system enhanced the skin permeation of the allergen

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Rakhmatullina, N. M., Yu V. Pastushenko, O. R. Trofimova, N. A. Sibgatullina, D. G. Akhmedzyanova, and G. N. Zakirov. "Modern methods of allergen-specific immunotherapy in allergic rhinitis treatment." Kazan medical journal 97, no. 2 (April 15, 2016): 288–94. http://dx.doi.org/10.17750/kmj2016-288.

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The article presents the modern methods of allergen-specific immunotherapy in patients with allergic rhinitis. Allergen-specific immunotherapy - a method of treating allergic diseases, involves reducing the organism’s sensitivity to the allergen effects by repeated administration of allergen extract, starting with the minimum dose. Given the allergic rhinitis high prevalence, as well as its tendency to increase, strong interest in effective methods of its treatment is fully justified. Over the last 20 years, it has become clear that asthma and rhinitis are two types of manifestations of a sing

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Jacquet, Alain. "New Insights into the Molecular Basis of the House Dust Mite-Induced Allergic Response." Open Allergy Journal 2, no. 1 (July 13, 2009): 38–44. http://dx.doi.org/10.2174/1874838400902010038.

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House dust mite (HDM) represents world-wide one of the most common source of aeroallergens word-wide and more than 50% of allergic patients are sensitized to these allergenic molecules. Although the induction of specificTh2 cells as well as IgE by HDM is well understood, the events that control the initial Th2 polarization in response to HDM are still poorly defined. Notably, mechanisms by which HDM is recognized by the airway mucosa, interacts with barrier epithelial cells, leading to dendritic cell (DC) recruitment, activation, and subsequent Th2-mediated responses, remains to be elucidated.

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Lariou, Maria Stella, Stavroula Dikalioti, Nick Dessypris, Apostolos Pourtsidis, Margarita Baka, Sophia Polychronopoulou, Fani Athanasiadou Piperopoulou, et al. "Country specific serum IgE reactivity profile and concordance with allergic history among acute lymphoblastic leukemia children and controls." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): e20002-e20002. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e20002.

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e20002 Background: Allergy has been studied as a risk factor for several malignancies, including childhood leukemia; yet, the tentative etiological nature of this association needs to be further explored. Published studies suffer inappropriate study design and accuracy of exposure variables. In response to the latter need, this study aims to use country specific biological markers, namely levels of the most prevalent allergen-specific immunoglobulin E (IgE) antibodies in Greece as an alternative exposure measurement to history of allergy and compare their concordance with allergic history. Met

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Petalas, K., and S. R. Durham. "Allergen immunotherapy for allergic rhinitis." Rhinology journal 51, no. 2 (June 1, 2013): 99–110. http://dx.doi.org/10.4193/rhino12.086.

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Allergic rhinitis, a risk factor for bronchial asthma, is a global health problem that impairs patients` physical and social activity and consequently their quality of life. Specific Immunotherapy (SIT) involves the administration, subcutaneously or sublingually, of increasing doses of the causative allergen, in order to induce clinical and immunologic tolerance. SIT has been shown to be effective in those with a poor response to conventional drug therapy. Immunotherapy has been shown to have disease-modifying effects and result in long term remission of allergic symptoms and reduces the risk

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Rowane, Marija, Ryan Shilian, Devi K. Jhaveri, Haig H. Tcheurekdjian, Theordore H. Sher, and Robert Hostoffer. "Familial Success in Allergen Desensitization." Allergy & Rhinology 10 (January 2019): 215265671989031. http://dx.doi.org/10.1177/2152656719890315.

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Introduction Allergic rhinitis (AR) is a widely prevalent immunoglobulin E-mediated inflammatory nasal condition resulting from reexposure to an allergen in a sensitized individual. The genetic associations behind AR and other allergic conditions have been studied. However, familial success with AR therapies, specifically allergen desensitization through subcutaneous immunotherapy (SCIT), has never been reported in the literature. Pharmocogenetics has been gradually applied to link heritable genetic variants with drug responses, such as intergenic region variants APOBEC3B and APOBEC3C and β2-a

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Calzada, David, Lucía Cremades-Jimeno, María López-Ramos, and Blanca Cárdaba. "Peptide Allergen Immunotherapy: A New Perspective in Olive-Pollen Allergy." Pharmaceutics 13, no. 7 (July 2, 2021): 1007. http://dx.doi.org/10.3390/pharmaceutics13071007.

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Allergic diseases are highly prevalent disorders, mainly in industrialized countries where they constitute a high global health problem. Allergy is defined as an immune response “shifted toward a type 2 inflammation” induced by the interaction between the antigen (allergen) and IgE antibodies bound to mast cells and basophils that induce the release of inflammatory mediators that cause the clinical symptoms. Currently, allergen-specific immunotherapy (AIT) is the only treatment able to change the course of these diseases, modifying the type 2 inflammatory response by an allergenic tolerance, w

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Siddall, Hilary, Diana Quint, Hitesh Pandya, Will Powley, Shaila Shabbir, Jens M. Hohlfeld, Dave Singh, and Laurie Lee. "Intranasal GSK2245035, a Toll-like receptor 7 agonist, does not attenuate the allergen-induced asthmatic response in a randomized, double-blind, placebo-controlled experimental medicine study." PLOS ONE 15, no. 11 (November 9, 2020): e0240964. http://dx.doi.org/10.1371/journal.pone.0240964.

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Background Allergic asthma is a heterogenous disorder predominantly driven by a type 2 inflammatory response to aeroallergens. Therapeutic modulation to rebalance these type 2 responses may offer clinical benefit for allergic respiratory inflammatory diseases, with the potential for disease modification. GSK2245035, a selective toll-like receptor-7 agonist, preferentially stimulates the induction of type 1 interferon alpha, reducing type 2 responses. Objective This study investigated whether intranasal GSK2245035 reduced allergen-induced bronchial reactivity in mild allergic asthma. Methods Th

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Wilson, Mark S., Matthew D. Taylor, Adam Balic, Constance A. M. Finney, Jonathan R. Lamb, and Rick M. Maizels. "Suppression of allergic airway inflammation by helminth-induced regulatory T cells." Journal of Experimental Medicine 202, no. 9 (November 7, 2005): 1199–212. http://dx.doi.org/10.1084/jem.20042572.

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Allergic diseases mediated by T helper type (Th) 2 cell immune responses are rising dramatically in most developed countries. Exaggerated Th2 cell reactivity could result, for example, from diminished exposure to Th1 cell–inducing microbial infections. Epidemiological studies, however, indicate that Th2 cell–stimulating helminth parasites may also counteract allergies, possibly by generating regulatory T cells which suppress both Th1 and Th2 arms of immunity. We therefore tested the ability of the Th2 cell–inducing gastrointestinal nematode Heligmosomoides polygyrus to influence experimentally

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Zhao, Xiaoli, Suzan Thijssen, Hongbing Chen, Johan Garssen, Leon M. J. Knippels, and Astrid Hogenkamp. "Selenium Modulates the Allergic Response to Whey Protein in a Mouse Model for Cow’s Milk Allergy." Nutrients 13, no. 8 (July 22, 2021): 2479. http://dx.doi.org/10.3390/nu13082479.

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Cow’s milk allergy is a common food allergy in infants, and is associated with an increased risk of developing other allergic diseases. Dietary selenium (Se), one of the essential micronutrients for humans and animals, is an important bioelement which can influence both innate and adaptive immune responses. However, the effects of Se on food allergy are still largely unknown. In the current study it was investigated whether dietary Se supplementation can inhibit whey-induced food allergy in an animal research model. Three-week-old female C3H/HeOuJ mice were intragastrically sensitized with whe

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Pérez-Gómez, Cristina, José M. Segura, Miguel Blanca, Maite Asenjo, and José M. Matés. "Antioxidant activity levels and oxidative stress as blood markers of allergic response to drugs." Biochemistry and Cell Biology 78, no. 6 (December 1, 2000): 691–98. http://dx.doi.org/10.1139/o00-085.

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Antioxidant enzymes work together in human blood cells against toxic reactive oxygen species. Although their relationship with several pathophysiologic processes has been stated, not much is known about the connection between antioxidant defence and allergy. This study was designed to determine the enzymatic activities and the oxidative indices in the blood and serum proteins in patients suffering from allergy to drugs. We hypothesize that serum and blood reactions may serve as useful clinical marker for the allergic state. We used enzymatic antioxidant activities, thiobarbituric acid reactive

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Papia, Francesco, Chiara Bellia, and Carina Gabriela Uasuf. "Tropomyosin: A panallergen that causes a worldwide allergic problem." Allergy and Asthma Proceedings 42, no. 5 (September 1, 2021): e145-e151. http://dx.doi.org/10.2500/aap.2021.42.210057.

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Background: Panallergens are proteins that take part in key processes of organisms and, therefore, are ubiquitously distributed with highly conserved sequences and structures. One class of these panallergens is composed of the tropomyosins. The highly heat-stable tropomyosins comprise the major allergens in crustaceans and mollusks, which make them important food allergens in exposed populations. Tropomyosins are responsible for a widespread immunoglobulin E cross-reactivity among allergens from different sources. Allergic tropomyosins are expressed in many species, including parasites and ins

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Saliganti, Vamshi, Rajeev Kapila, Rohit Sharma, and Suman Kapila. "Feeding probiotic Lactobacillus rhamnosus (MTCC 5897) fermented milk to suckling mothers alleviates ovalbumin-induced allergic sensitisation in mice offspring." British Journal of Nutrition 114, no. 8 (September 2, 2015): 1168–79. http://dx.doi.org/10.1017/s000711451500286x.

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AbstractThe neonatal period is often polarised to T helper (Th2) response at the time of birth, predisposing offspring to allergic disorders. Passive immunity through the mother’s milk is critical for immune system development of newborns. Probiotics have been proposed to harmonise Th1/Th2 imbalance in allergic conditions in adults. In the present study, the anti-allergic effects of feeding probiotic Lactobacillus rhamnosus-fermented milk (PFM) either to dams during the suckling period or to their offspring after weaning individually or else in successive periods against ovalbumin (OVA)-induce

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Msallam, Rasha, Jozef Balla, Abhay P. S. Rathore, Hassen Kared, Benoit Malleret, Wilfried A. A. Saron, Zhaoyuan Liu, et al. "Fetal mast cells mediate postnatal allergic responses dependent on maternal IgE." Science 370, no. 6519 (October 29, 2020): 941–50. http://dx.doi.org/10.1126/science.aba0864.

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Mast cells (MCs) are central effector cells in allergic reactions that are often mediated by immunoglobulin E (IgE). Allergies commonly start at an early age, and both MCs and IgE are detectable in fetuses. However, the origin of fetal IgE and whether fetal MCs can degranulate in response to IgE-dependent activation are presently unknown. Here, we show that human and mouse fetal MCs phenotypically mature through pregnancy and can be sensitized by maternal IgE. IgE crossed the placenta, dependent on the fetal neonatal Fc receptor (FcRN), and sensitized fetal MCs for allergen-specific degranulat

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Gushchin, I. S. "Transepithelial initiation of allergic response." Russian Journal of Allergy 13, no. 3 (December 15, 2016): 3–10. http://dx.doi.org/10.36691/rja346.

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Furrie, Elizabeth. "Probiotics and allergy." Proceedings of the Nutrition Society 64, no. 4 (November 2005): 465–69. http://dx.doi.org/10.1079/pns2005466.

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Allergy is caused by an immune reaction that is out of all proportion to the antigenic stimuli. Classical allergy is a type I hypersensitivity reaction mediated by the interaction of mast cells (and eosinophils) coated with allergen-specific IgE and a cross-linking allergen. The physiological outcome is inflammation commonly displayed by urticaria, rhinitis, vomiting and diarrhoea, depending on the route of allergen entry. In extreme reactions anaphylactic shock can result that may lead to death. Chronic allergic responses most commonly present themselves as asthma and eczema. All these sympto

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Arcimowicz, Magdalena, and Edyta Krzych-Fałta. "Nasal allergen challenge - an important tool in diagnosis of rhinologic disease." Polski Przegląd Otorynolaryngologiczny 9, no. 4 (December 19, 2020): 1–5. http://dx.doi.org/10.5604/01.3001.0014.6068.

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The nasal allergen challenge (NAC) is used in the diagnosis of rhinitis. The primary use of NAC is to confirm allergy to a specific inhaled allergen. NAC reproduces the allergic reaction of the nasal mucosa under standardized and controlled conditions that occurs after direct intranasal administration of allergens. As the only used method for assessing the degree of allergy, it mimics the body’s natural response to the sensitizing factor in the early and late stages of an allergic reaction. NAC is used in the diagnosis of chronic, occupational and local rhinitis, as well as in the differential

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Alashkar Alhamwe, Bilal, Laura A. P. M. Meulenbroek, Désirée H. Veening-Griffioen, Tjalling M. D. Wehkamp, Fahd Alhamdan, Sarah Miethe, Hani Harb, et al. "Decreased Histone Acetylation Levels at Th1 and Regulatory Loci after Induction of Food Allergy." Nutrients 12, no. 10 (October 19, 2020): 3193. http://dx.doi.org/10.3390/nu12103193.

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Immunoglobulin E (IgE)-mediated allergy against cow’s milk protein fractions such as whey is one of the most common food-related allergic disorders of early childhood. Histone acetylation is an important epigenetic mechanism, shown to be involved in the pathogenesis of allergies. However, its role in food allergy remains unknown. IgE-mediated cow’s milk allergy was successfully induced in a mouse model, as demonstrated by acute allergic symptoms, whey-specific IgE in serum, and the activation of mast cells upon a challenge with whey protein. The elicited allergic response coincided with reduce

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Cockcroft, Donald W., Fredrick E. Hargreave, Paul M. O’Byrne, and Louis-Philippe Boulet. "Understanding Allergic Asthma from Allergen Inhalation Tests." Canadian Respiratory Journal 14, no. 7 (2007): 414–18. http://dx.doi.org/10.1155/2007/753450.

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The allergen challenge has evolved, in less than 150 years, from a crude tool used to document the etiology of allergen-induced disease to a well-controlled tool used today to investigate the pathophysiology and pharmacotherapy of asthma. Highlights of the authors’ involvement with the allergen challenge include confirmation of the immunoglobulin E-dependence of the late asthmatic response, importance of (nonallergic) airway hyper-responsiveness as a determinant of the airway response to allergen, identification of allergen-induced increase in airway hyper-responsiveness, documentation of beta

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Baroody, Fuad M., Samantha M. Mucha, Marcy deTineo, and Robert M. Naclerio. "Evidence of Maxillary Sinus Inflammation in Seasonal Allergic Rhinitis." Otolaryngology–Head and Neck Surgery 146, no. 6 (February 1, 2012): 880–86. http://dx.doi.org/10.1177/0194599811435972.

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Objective. Allergic rhinitis has been frequently associated with both acute and chronic sinusitis. Previous studies have shown an influx of eosinophils into the maxillary sinus after nasal challenge with allergen. The objective of this study was to determine, in humans, if the development of seasonal allergic inflammation, secondary to natural allergen exposure, leads to similar inflammation within the maxillary sinus. Study Design. Prospective, longitudinal study. Setting. Academic medical center and research laboratory. Subjects and Methods. Eighteen subjects were evaluated in and out of the

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Raza, Fahad, Susanna Babasyan, Elisabeth M. Larson, Heather S. Freer, Christiane L. Schnabel, and Bettina Wagner. "Peripheral blood basophils are the main source for early interleukin-4 secretion upon in vitro stimulation with Culicoides allergen in allergic horses." PLOS ONE 16, no. 5 (May 26, 2021): e0252243. http://dx.doi.org/10.1371/journal.pone.0252243.

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Interleukin-4 (IL-4) is a key cytokine secreted by type 2 T helper (Th2) cells that orchestrates immune responses during allergic reactions. Human and mouse studies additionally suggest that basophils have a unique role in the regulation of allergic diseases by providing initial IL-4 to drive T cell development towards the Th2 phenotype. Equine Culicoides hypersensitivity (CH) is a seasonal immunoglobulin E (IgE)-mediated allergic dermatitis in horses in response to salivary allergens from Culicoides (Cul) midges. Here, we analyzed IL-4 production in peripheral blood mononuclear cells (PBMC) o

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Choudhary, Shazia, Mamoona Noreen, Muhammad Arshad, and Muhammad Arshad. "Pollen Allergy; Mechanism and Etiology." NUST Journal of Natural Sciences 1, no. 1 (February 7, 2021): 16–19. http://dx.doi.org/10.53992/njns.v1i1.26.

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The term allergy refers to an exaggerated immune response to a foreign molecule. In a normal healthy individual, this foreign molecule will act as a harmless antigen, as it will be recognized & cleared by the immune system without causing any significant damage to host tissues. In certain individuals, such antigens stimulate immune system in such a way that a series of exaggerated immune response are generated against it, leading to significant tissue injury and damage to the host. Such as exaggerated immune response may also cause death of the patient. Such antigen is termed as an allerge

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Nam, Joo Hyun, and Woo Kyung Kim. "The Role of TRP Channels in Allergic Inflammation and its Clinical Relevance." Current Medicinal Chemistry 27, no. 9 (March 27, 2020): 1446–68. http://dx.doi.org/10.2174/0929867326666181126113015.

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Allergy refers to an abnormal adaptive immune response to non-infectious environmental substances (allergen) that can induce various diseases such as asthma, atopic dermatitis, and allergic rhinitis. In this allergic inflammation, various immune cells, such as B cells, T cells, and mast cells, are involved and undergo complex interactions that cause a variety of pathophysiological conditions. In immune cells, calcium ions play a crucial role in controlling intracellular Ca2+ signaling pathways. Cations, such as Na+, indirectly modulate the calcium signal generation by regulating cell membrane

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Rybachok, Oksana. "July 8, 2020 — World Allergy Day." Spravočnik vrača obŝej praktiki (Journal of Family Medicine), no. 7 (July 1, 2020): 69–73. http://dx.doi.org/10.33920/med-10-2007-10.

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Decision to celebrate World Allergy Day was adopted in 2005 at the initiative of the World Allergy Organization. The purpose of the initiative is to inform the general public about the symptoms of allergic manifestations, to promote regular inspections and examinations. One third of the adult population of the Russian Federation and one fourth of children and adolescents periodically suffer from manifestations caused by allergies. This disease is an immunopathological response of the body to the action of an agent as a result of the development of sensitization to it. Currently, there is a ten

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Skoner, David P., William J. Doyle, Sharon Boehm, and Philip Fireman. "Late Phase Eustachian Tube and Nasal Allergic Responses Associated with Inflammatory Mediator Elaboration." American Journal of Rhinology 2, no. 4 (September 1988): 155–61. http://dx.doi.org/10.2500/105065888781692998.

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Previous work in our laboratories has documented an IgE-mediated functional obstruction of the nose and eustachian tube (ET) immediately after nasal allergen challenge. The goals of this study were to monitor changes in nasal, ET, and bronchial physiology during the 12 hours following nasal allergen challenge and to correlate these changes with the elaboration of inflammatory mediators (IM). Subjects with ragweed allergic rhinitis were challenged intranasally with 2.5 mg of ragweed/nostril, and responses were assessed by posterior rhinomanometry for the nasal airway, sonotubometry for the eust

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Wang, Yui-Hsi. "Developing food allergy: a potential immunologic pathway linking skin barrier to gut." F1000Research 5 (November 10, 2016): 2660. http://dx.doi.org/10.12688/f1000research.9497.1.

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Immunoglobulin E (IgE)-mediated food allergy is an adverse reaction to foods and is driven by uncontrolled type-2 immune responses. Current knowledge cannot explain why only some individuals among those with food allergy are prone to develop life-threatening anaphylaxis. It is increasingly evident that the immunologic mechanisms involved in developing IgE-mediated food allergy are far more complex than allergic sensitization. Clinical observations suggest that patients who develop severe allergic reactions to food are often sensitized through the skin in early infancy. Environmental insults tr

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