Academic literature on the topic 'Allergie aux Acariens – Physiopathologie'
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Journal articles on the topic "Allergie aux Acariens – Physiopathologie":
Morad, S., N. Zaghba, H. Benjelloun, A. Bakhatar, N. Yassine, and A. Bahlaoui. "Allergie croisée à l’escargot et aux acariens." Revue des Maladies Respiratoires 30 (January 2013): A62. http://dx.doi.org/10.1016/j.rmr.2012.10.197.
Fauquert, J. L., A. Labbe, F. Bacin, and H. Dalens. "Uvéite et allergie aux acariens: entité discutée." Revue Française d'Allergologie et d'Immunologie Clinique 29, no. 3 (July 1989): 153. http://dx.doi.org/10.1016/s0335-7457(89)80038-3.
Petrus, M., M. Nyunga, E. Causse, E. Chung, and G. Cossarizza. "Allergie au calmar et aux acariens chez l'enfant." Archives de Pédiatrie 6, no. 10 (October 1999): 1075–76. http://dx.doi.org/10.1016/s0929-693x(00)86982-1.
Petrus, M., V. Cougnaud, M. Rhabbour, E. Causse, and JC Netter. "Allergie à l’escargot et aux acariens chez l’enfant." Archives de Pédiatrie 4, no. 8 (August 1997): 767–69. http://dx.doi.org/10.1016/s0929-693x(97)83419-7.
Laur, C., E. Bidat, and L. Guérin. "Allergie aux acariens : quels moyens de contrôle de l'environnement conseiller aux patients ?" Revue Française d'Allergologie et d'Immunologie Clinique 37, no. 2 (March 1997): 200–205. http://dx.doi.org/10.1016/s0335-7457(97)80046-9.
Dutau, G. "Allergie aux acariens domestiques : du diagnostic à la prise en charge." Revue Française d'Allergologie 54, no. 8 (December 2014): 544–53. http://dx.doi.org/10.1016/j.reval.2014.10.003.
Boukhettala, N., S. Bourgeon, A. Porée, and T. Porée. "Analyse d’un questionnaire de suivi chez des personnes présentant une allergie aux acariens et utilisant des housses anti-acariens." Revue Française d'Allergologie 52, no. 3 (April 2012): 260–61. http://dx.doi.org/10.1016/j.reval.2012.02.041.
Agodokpessi, G., S. Dossou-Yovo, C. Bigot, T. Hountohotegbe, G. Sagbo, S. Ade, P. Wachinou, B. Awanou, and A. Bigot. "Sensibilisation aux acariens chez les enfants suivis pour allergie respiratoire en milieu tropical africain." Revue des Maladies Respiratoires 33 (January 2016): A29. http://dx.doi.org/10.1016/j.rmr.2015.10.633.
Banzet, M. L., B. Adessi, D. A. Vuitton, and L'Amecoforcal. "Manifestations allergiques après ingestion d'escargots chez 12 malades allergiques aux acariens : une nouvelle allergie croisée ?" Revue Française d'Allergologie et d'Immunologie Clinique 32, no. 4 (October 1992): 198–202. http://dx.doi.org/10.1016/s0335-7457(05)80359-4.
Demoly, P. "Allergie aux acariens. Diagnostic, prise en charge et modalités de l’ITA chez les patients poly-allergiques." Revue Française d'Allergologie 57, no. 2 (March 2017): 83–90. http://dx.doi.org/10.1016/j.reval.2017.02.004.
Dissertations / Theses on the topic "Allergie aux Acariens – Physiopathologie":
Audousset, Camille. "Implication du récepteur NOD1 dans l’asthme allergique aux acariens & Impact fonctionnel des bouchons de mucus dans les voies aériennes de patients asthmatiques sévères selon leur statut tabagique." Thesis, Université de Lille (2018-2021), 2021. https://pepite-depot.univ-lille.fr/ToutIDP/EDBSL/2021/2021LILUS050.pdf.
Asthma is a chronic inflammatory airway disease responsible for significant morbidityand mortality defined by an association between clinical symptoms and variable airwayobstruction. The cardinal features of asthma are airway hyperresponsiveness, bronchialinflammation associated with changes in the structure of the bronchi including overproductionof mucus. Taken together, these characteristics result in numerous clinical presentations,called asthmatic phenotypes, which are the consequence of multiple distinctpathophysiological mechanisms. The most common asthma phenotype is allergic asthma, ofwhich house dust mites are one of the main pneumallergens. The heterogeneity of thispathology requires a comprehensive approach including fundamental work and translationalclinical approach. These two approaches have been developed in this thesis.In the first part, the involvement of an innate immunity receptor, the Nod1 receptor, inhouse dust mite allergic asthma was investigated. This receptor recognizes fragments ofbacterial peptidoglycans and participates in the immune response. It is also involved in theregulation of the digestive microbiota. In Nod1-/- mice, the mite-induced asthmatic allergicparameters are reduced compared to wild type mice. This attenuation of the allergicasthmatic response is not linked to a change in the digestive flora of Nod1-/- mice. In contrast,mite extracts contain microbial flora, mainly composed of gram-negative bacillus, capable ofdirectly activating the Nod1 receptor in the epithelium of the respiratory tract. This activationcontributes to the exacerbation of the allergic asthmatic response induced by house dustmites and offers a new therapeutic perspective in the treatment of allergic asthma to housedust mites.The second part of this work is devoted to the functional impact of mucus plugspresent in the airways of asthma patients according to their smoking status using previouslydeveloped tools. The presence of mucus plugs was common regardless of the smokingstatus of the asthmatics. An inverse correlation was found between the number of lungsegments with at least one mucus plug and airway obstruction. This clinical feature wascorrelated with the percentage of eosinophils in the sputum. In patients with a history ofsmoking, the presence of airway obstructions was correlated with the percentage ofneutrophils. Mucus plugs appear to be a marker of asthma severity and are correlated withdifferent types of bronchial inflammation depending on smoking status.This PhD has helped advance fundamental and clinical-functional knowledge inasthma. These results invite further investigations in these different fields
Caux, Denarnaud Patricia. "La désensibilisation accélérée aux acariens chez l' enfant : à propos du suivi de 15 observations." Clermont-Ferrand 1, 1987. http://www.theses.fr/1987CLF11006.
Braza, Fouazi. "Étude d'une population B régulatrice dans un modèle murin d'asthme allergique aux acariens." Nantes, 2014. http://www.theses.fr/2014NANT32VS.
Essentially described for their role in humoral immunity, B cells are increasingly described for their ability to regulate inflammatory responses. We can so distinguish inflammatory and regulatory B cells able to regulate the activation of immune cells. Regulatory B cells are of special interest today. Several studies described their capacity to control inflammation in transplantation and autoimmunity. These cells are mainly characterized by the production of IL-10. They are able to inhibit many and control many components of the immune system in order to maintain immunological tolerance. Allergic asthma is typically a situation where immune tolerance is broken in response to respiratory allergen. In this pathology, regulatory mechanisms were essentially reduced to the simple description of the regulatory T cells. Given the importance of regulatory B cells in immune regulation, these cells represent a potential interest in asthma Then the work of this thesis focus on the phenotypic and functional characterization of these cells in a model of allergic asthma due to mites
Bertel, Franck. "Évaluation d'un test de provocation conjonctivale au Dermatophagoi͏̈de Pteronyssinus pour le diagnostic des conjonctivites allergiques aux acariens." Bordeaux 2, 1998. http://www.theses.fr/1998BOR23014.
Gaspard, Isabelle. "Role de l'interleukine-4 dans la physiopathologie de l'allergie aux beta-lactames." Paris 5, 1999. http://www.theses.fr/1999PA05N140.
Rigaux, Peter. "Evaluation des propriétés immunomodulatrices de la bactérie lactique Lactobacillus plantarum NCIMB8826 dans le cadre de l'allergie aux acariens." Doctoral thesis, Universite Libre de Bruxelles, 2008. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210414.
Dès lors, nous avons caractérisé les propriétés immunomodulatrices qu’exerce Lactobacillus plantarum NCIMB8826, une bactérie lactique modèle, sur la cellule dendritique étant donné le rôle déterminant de cette cellule sur la réponse allergique. Nous montrons que L. plantarum induit une forte sécrétion d’IL-12 p40, d’IL-12 p70, de TNF-a mais une faible production d’IL-10. Cette faculté à induire la sécrétion de cytokines polarisantes dépend de TLR2, de TLR9, de MyD88, de NF-kB, des MAPKs (en particulier JNK, p38 et ERK 1/2), de la composition de l’acide lipotéichoïque de L. plantarum et de CD14. Nous montrons aussi que l’ADN génomique de L. plantarum est un agoniste de TLR9 et que CD14 et CD36 facilitent la liaison de la cellule dendritique avec L. plantarum.
Ensuite, nous avons évalué le potentiel vaccinal d’une coadministration L. plantarum + Der p 1 dans un modèle murin d’allergie à Der p 1. Cette formulation vaccinale prévient la production d’IgE Der p 1-spécifique et atténue l’éosinophilie pulmonaire tout en stimulant une forte production d’anticorps IgG2a Der p 1-spécifiques et d’IFN-g par les cellules spléniques. Ces effets bénéfiques nous ont conduit à élaborer une bactérie lactique recombinante dérivée de L. plantarum produisant Der p 1 pour la vaccination contre l’allergie aux acariens. La forme antigénique que nous avons réussi à faire produire par L. plantarum correspond à une protéine de fusion entre la Maltose Binding Protein de E. coli et ProDer p 1 (le zymogène de Der p 1), la présence de ce partenaire de fusion étant indispensable à la production de ProDer p 1. En prophylaxie, la vaccination par cette bactérie recombinante prévient la production d’anticorps IgE-Der p 1-spécifiques et stimule la production d’anticorps IgG2a spécifiques, reproduisant les effets de la coadministration L. plantarum + Der p 1. Elle réduit de manière drastique la production d’IL-5 des cellules spléniques et des cellules ganglionnaires médiastinales et prévient l’éosinophilie pulmonaire mais n’a pas d’effet sur l’hyperréactivité bronchique. Der p 1 étant un des allergènes d’acarien les plus immunodominants, cet ensemble de données montre donc que cette bactérie recombinante constitue un vaccin prophylactique prometteur pour la prévention de l’allergie aux acariens. Des résultats préliminaires obtenus à partir de cellules dendritiques humaines et lymphocytes T autologues montrent la forte capacité de cette bactérie recombinante à induire le développement d’une réponse Th1 fortement polarisée (production d’IFN-g en l’absence de production d’IL-4 et d’IL-5), ce qui suggère que l’utilisation de cette bactérie recombinante pourrait être envisagée pour le traitement de l’allergie chez l’homme.
Doctorat en Sciences agronomiques et ingénierie biologique
info:eu-repo/semantics/nonPublished
Bonneville, Marlène Nicolas Jean-François. "Physiopathologie de l'inflammation cutanée rôle de l'activation de l'immunité innée cutanée dans le développement de l'eczema allergique de contact /." [s.l.] : [s.n.], 2006. http://tel.archives-ouvertes.fr/docs/00/12/52/71/PDF/these_MBfinal.pdf.
Bonneville, Marlène. "Physiopathologie de l'inflammation cutanée : rôle de l'activation de l'immunité innée cutanée dans le développement de l'eczema allergique de contact." Lyon 1, 2006. http://tel.archives-ouvertes.fr/docs/00/12/52/71/PDF/these_MBfinal.pdf.
Haptens are endowed with pro-inflammatory and antigenic properties responsible for activation of both innate and acquired immunity leading to irritant and allergic contact dermatitis, respectively. Although it has been established that the frequency with which individuals develop allergic contact dermatitis directly correlates with the pro-inflammatory properties of haptens, the pathophysiological mechanisms linking irritancy and allergy are still not known precisely. In the first part of the thesis, we show that the development and severity of allergic contact dermatitis depends on the ability of haptens to deliver non specific inflammatory signals during sensitization, leading to: i) irritant contact dermatitis, ii) recruitment of dendritic cell precursors into the skin, iii) migration rate of dendritic cells to the lymph nodes where T cell activation occurs and, iv) T cell recruitment into the skin. The second part of this work concerns the study of the role of Toll-like receptor-2 (TLR-2), an innate immune receptor, in the development of allergic contact dermatitis. We demonstrate that the absence of TLR-2 in sensitized mice leads to an exacerbate allergic contact dermatitis, indicating that TLR-2 is involved in the down-regulation of the skin inflammation. Collectively, our results demonstrate that irritancy conditions the magnitude of allergic responses. Therefore, molecules able to decrease the pro-inflammatory properties of haptens could be new preventive or curative treatments of both irritant and allergic contact dermatitis
Michaud, Bénédicte. "Etude de la réponse lymphocytaire T dans l’allergie de l’enfant, au diagnostic et au cours de la désensibilisation." Thesis, Paris 5, 2013. http://www.theses.fr/2013PA05T025/document.
Allergic diseases are steadily increasing steadily and especially in children. Allergen specific immunotherapy (desensitization) is the only curative treatment for which accurate diagnosis of allergy is essential. Currently, the presence of specific IgE diagnoses a sensitization to an allergen but not a clinically symptomatic allergy. In a first part, we studied the value of a functional test, the ELISpot (Enzyme-linked immunosorbent spot) in the diagnosis of allergy to house dust mites (HDM). The number of circulating HDM-specific IL-4 and IL-13 secreting T cells was associated with the presence of symptoms, regardless of specific IgE and was higher in severe rhinitis than in mild rhinitis. In addition, it varied according to the season with a peak in autumn and a peak in early spring (wet periods with greater allergen exposure). In a second part, we studied the value of ELISpot for the diagnosis of cow's milk allergy in children, confirmed by double blind placebo control food challenge. We found that the number of casein-specific IL-4 and IL -13 secreting T-cells was associated with allergy to cow's milk. It was also inversely correlated to the cow’s milk tolerated cumulative dose. Receiver-operating characteristic (ROC) curve of combined IL-4 and IL-13 analysis was generated. AUC was 0,98 (95% CI 0.90-1.06). For a cut-off of 10 IL-4- and 12 IL-13 secreting T-cells, sensitivity and negative predictive value were 100%.Finally, in the third part, we monitored antigen specific T-cell response in HDM allergic children treated with sublingual ITA (SLIT) on the one hand and subcutaneous ITA (SCIT) on the other hand, during one year. We found a decrease in HDM specific Th2 cells after 12 months of SLIT associated with an increase in HDM specific IL-10 secreting T-cells after 6 months of SLIT. In addition, regulatory T cells (CD4 + CD25hiCD127loFoxp3+) were increased after 12 months of SCIT. In conclusion, this work has allowed us to describe a functional test, the ELISpot, as a reliable tool for the diagnosis of mite allergy and cow's milk allergy in children. In addition, in HDM allergic children, a decrease of Th2 cells and an increase of IL-10 secreting T-cells was found in children treated with SLIT to HDM as well as an increase in Foxp3+ Treg in children treated with SCIT
Naegele, Alexandre. "Impact des acariens et des micro-organismes de l'habitat dans le développement de l'asthme et de la broncho-pneumopathie chronique obstructive (BPCO)." Thesis, Besançon, 2015. http://www.theses.fr/2015BESA3019/document.
Our will to save energy leads us to live in a confined environment providing the ideal conditions to mites and microorganisms development. The aim of the thesis is to characterize mites and microorganisms contamination of dwellings from patients suffering respiratory diseases, to estimate the influence of the interactions between various organic communities on the allergens exposure and to understand the factors increasing the biological pollution ofindoor air. To evaluate our exposition, we needed to quantify mites and microorganisms with a common tool and an innovative quantification mode! of domestic mites by qPCR was developed. The presence of storage mites is overemphasized in dwellings of allergie patients and the eviction measures of mites should be applied into any rooms of dwellings. The contamination of dairy fanners' dwellings suffering from COPD was compared with that ofhealthy dairy fanners, COPC patients non-farmers and healthy non-fanners. In dwellings, the dairy fanners' exposure was important and specific ofth1 fanning environment. The lgG sensitivity to Wallemia sebi was significantly specific of dairy fanners suffering from COPD. The impact of the composting on the biological air quality was evaluated and the concentrations in storage mites and some molds increased significantly only in a confined area around the waste bin. New common indicators of domestic mites, molds and bacteria should allow us to progress in the determination of the dose-response relationship for the different allergens and their possible synergie effects