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Journal articles on the topic 'Allergy'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Norbäck, Dan, and Gunilla Wieslander. "A Review on Epidemiological and Clinical Studies on Buckwheat Allergy." Plants 10, no. 3 (2021): 607. http://dx.doi.org/10.3390/plants10030607.

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Background: Cultivated buckwheat include two species originating from China: common buckwheat (Fagopyrum esculentum) and tartary buckwheat (Fagopyrum tartaricum). Buckwheat can cause IgE-mediated allergy, including severe allergic reactions and anaphylaxis. Exposure can occure when eating buckwheat food (food allergen), when producing or handling buckwheat food (occupational exposure) or when sleeping on buckwheat husk pillows (houeshold environmental exposure). Methods: A search on buckwheat allergy in the medical datbase PubMed from 1970–2020. Result: A number of allergenic proteins have bee

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Brand, Paul L. P., Richard M. Brohet, Olof Schwantje, and Lambert D. Dikkeschei. "Association between allergen component sensitisation and clinical allergic disease in children." Allergologia et Immunopathologia 50, no. 2 (2022): 131–41. http://dx.doi.org/10.15586/aei.v50i2.598.

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Background: Allergen component sensitisation testing is becoming increasingly important in the diagnosis of peanut allergy. The aim of the present study was to evaluate the relationship between sensitisation and symptoms of allergic disease in children by testing a large panel of inhalants, food allergens, and allergen components. Methods: For 287 children visiting our laboratory for allergy testing, symptoms of allergic disease were recorded by standardised validated questionnaires. Specific IgE to 11 whole allergens was assessed by ImmunoCAP, and to 112 allergen components by ISAC ImmunoCAP

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3

Lunhui, Huang, Shao Yanhong, Li Shaoshen, Bao Huijing, Liu Yunde, and Li Huiqiang. "Component resolved diagnosis of egg yolk is an indispensable part of egg allergy." Allergologia et Immunopathologia 49, no. 2 (2021): 6–14. http://dx.doi.org/10.15586/aei.v49i2.31.

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Introduction and objectives: It was urgent to explain the role of egg yolk allergen sensitization to the egg allergic population and we would evaluate the diagnostic value of allergen components in whole eggs, including egg white and egg yolk.Materials and methods: Firstly, we collected 99 positive and 21 negative sera against egg allergy. Then we used modified enzyme linked immunosorbent assay (ELISA) to survey specific IgE (sIgE) to all-proven and single component in eggs, Ovomucoid (Gal d 1), Ovalbumin (Gal d 2), Ovotransferrin (Gal d 3), Lysozyme C (Gal d 4), Serum Albumin (Gal d 5), and Y

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Callery, Emma L., Catherine Keymer, Nicholas A. Barnes, and Anthony W. Rowbottom. "Component-resolved diagnostics in the clinical and laboratory investigation of allergy." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 57, no. 1 (2019): 26–35. http://dx.doi.org/10.1177/0004563219877434.

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The diagnosis and management of allergy is complex; the clinical symptoms associated with allergic reactions span a broad spectrum of severity, from mild hay fever-type symptoms through to life-threatening anaphylaxis. Obtaining an allergy-focused clinical history is therefore vital for identifying possible allergic triggers and directing testing. However, this focus could be changing as scientific and technological advances have paved the way for developments within in vitro testing for allergy. With knowledge of allergens at the molecular level expanding, there are now the facilities to char

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Yu, Esther Dawen, Eric Wang, Aaron Sutherland та ін. "Functional characterization of gamma-delta (γδ) T cells in allergy". Journal of Immunology 206, № 1_Supplement (2021): 23.02. http://dx.doi.org/10.4049/jimmunol.206.supp.23.02.

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Abstract Despite a growing consensus on the involvement of γδ T cells in allergy and other human immunological disorders, the detailed mechanisms remain hypothetical due to lack of investigative tools. Herein, we sought to develop functional assays to study the role of γδ T cells in allergy. Using an Activation-Induced Marker (AIM) assay, based on the upregulation of 4-1BB (CD137) and CD69, we were able to detect ex vivo allergen-specific responses from γδ T cells to multiple allergen extracts in human PBMCs, including mouse, cockroach (CR), house dust mite (HDM) and timothy grass (TG) allerge

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Lohonková, A., O. Novotná, P. Petrásková, K. Boráková, L. Prokešová, and Jiří Hrdý. "Maternal Allergy Status Has No Impact on Neonatal Immune Responses to Allergen Stimuli." Folia Biologica 65, no. 5-6 (2019): 221–26. http://dx.doi.org/10.14712/fb2019065050221.

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Due to the increasing incidence of allergic diseases, there is a strong need to identify a prognostic marker pointing to increased risk of allergy development allowing introduction of early preventive measures. Cord blood seems to be a good source for searching for such marker. The capacity of cord blood cells to respond to common allergens could point to increased predisposition to later allergy development. In our study, cytokines typical of Th1 (IFN-γ), Th2 (IL-5, IL-13) and Treg (IL-10) immune responses were followed at both the level of gene expression and cytokine secretion in cord blood

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7

Choina, Magdalena, Weronika Gromek, Klaudia Wilk, Magdalena Marzęda, and Roman Pukaliak. "The molecular diagnosis of house dust mite allergy: a short review." Journal of Education, Health and Sport 12, no. 8 (2022): 707–13. http://dx.doi.org/10.12775/jehs.2022.12.08.071.

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Introduction: House dust mite (HDM) allergens are considered among the most essential elicitors of allergic rhinitis and asthma worldwide [1]. How can we determine the individual sensitization profile of a patient? Is there a way to monitor the development of allergic symptoms? Is it possible to tailor different forms of therapy based on the individual sensitization profile of a patient? Purpose: The study aims to show the benefits of molecular diagnostics of allergies based on the example of HDM allergy. Description of the state of knowledge: Clinical manifestation is the most imp

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Bloodworth, Jeffrey C., Aki Hoji, and Joan Cook-Mills. "Lung microbial dysbiosis during early life promotes predisposition to allergic asthma." Journal of Immunology 210, no. 1_Supplement (2023): 67.26. http://dx.doi.org/10.4049/jimmunol.210.supp.67.26.

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Abstract Background: Allergic asthma is associated with lung microbial dysbiosis. We hypothesized that the microbiome from the lungs of allergy-predisposed mouse pups is sufficient to predispose pups to development of allergy. Allergic inflammation in pups of allergic dams is blocked by α-tocopherol supplementation of the dam during gestation and nursing, but it is unknown whether α-tocopherol alters microbial composition of the lung. Methodology: Mouse pups were predisposed to allergy by inducing allergy in the mothers. Microbiome was separated from the bronchoalveolar lavage (BAL) of pups of

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Foong, Ru-Xin, and Alexandra F. Santos. "Oral Tolerance Induction—Opportunities and Mechanisms." Foods 11, no. 21 (2022): 3386. http://dx.doi.org/10.3390/foods11213386.

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Oral tolerance is the active absence of response to food allergens, which involves complex mechanisms in the gut-associated lymphoid tissue. Food allergy results from the disruption of such tolerance or the absence of its establishment in the first place. It follows allergic sensitization with the production of allergen-specific IgE and results from the degranulation of basophils and mast cells on subsequent exposure to the allergen. Oral tolerance induction has been explored in the contexts of prevention and treatment of food allergy. Early introduction of allergenic foods (i.e., egg and pean

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Bloodworth, Jeffrey C., Aki Hoji, Ross Blankenship, and Joan Cook-Mills. "Maternal beta-glucosylceramide induces the generation of IRF4+ dendritic cells in offspring of allergic mothers." Journal of Immunology 210, no. 1_Supplement (2023): 156.12. http://dx.doi.org/10.4049/jimmunol.210.supp.156.12.

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Abstract Background: β-glucosylceramides (βGlcCers) are elevated in allergic mouse dams and are necessary and sufficient to induce allergy predisposition in offspring. βGlcCers increase dendritic cell (DC) numbers in the fetal liver and pup lungs. We hypothesize that these lung DCs predispose offspring to allergic lung responses. We also hypothesize that βGlcCers induce elevated pro-allergy IRF4+ DC numbers during fetal hematopoiesis. Methods: Pregnant mice were injected with a mixture of βGlcCers known to predispose offspring to allergic asthma. DCs were assayed by flow cytometry. In another

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Simbirtsev, A. S. "Cytokines and their role in immune pathogenesis of allergy." Russian Medical Inquiry 5, no. 1 (2021): 32–37. http://dx.doi.org/10.32364/2587-6821-2021-5-1-32-37.

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Allergy is characterized by inadequate hyperimmune response to one or several antigens with the properties of allergens. A specific pattern of abnormal synthesis of some cytokines (principal molecular mediators of the initiation, development, and regulation of allergic inflammation) has an important pathogenic role in allergy. In recent years, it is generally accepted that allergic disorders are accounted for by impaired immune regulation resulting from increased imbalanced activation of allergen-specific T helper 2 cell clones. Allergic type of immune response is currently referred to as type

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Patel, Vivek, Lomash Sahu, Rajesh Kumar Nema, and Suchita Wamankar. "A Review: An Allergic Reaction." International Journal of Advanced Multidisciplinary Research and Studies 4, no. 6 (2024): 811–14. https://doi.org/10.62225/2583049x.2024.4.6.3516.

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Allergic reaction is a sudden respond of immune system when any dust particle or pollen grain will enter in body through nose or mouth it causes allergy because immune system doesn’t accept any other particles. This pollen and any other dust particle or those substance causes allergy it’s are harmful for our body sometimes it may cause disease various types. Sometimes these allergens cause skin rashes and skin irritation or this is the most common symptoms of allergy when any allergen wants to inter in body through nose it will sudden react and started sneezing and dry cough with runny nose an

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13

Ogorodova, L. M., O. S. Fedorova, M. M. Fedotova, and T. A. Evdokimova. "Peanut allergy: update concepts." Russian Journal of Allergy 10, no. 3 (2013): 3–10. http://dx.doi.org/10.36691/rja589.

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Allergy to peanuts is an actual problem of practical health care associated with a significant prevalence and severity of peanut-allergic reactions, which can include anaphylaxis. The characteristic of peanut allergen components is presented in the review. Modern approaches to the diagnosis of allergy to peanuts reflected in the article. The article presents research findings on development and natural history of allergy to peanuts, clinical mmanifestations, also considered the priority therapeutic approaches.

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Trushina, E. Y., E. M. Kostina, E. A. Orlova, A. A. Turovskaya, and T. A. Nefedova. "Experience of allergen-specific immunotherapy in the patient with oral and systemic manifestations of birch pollen allergy." Allergology and Immunology in Paediatrics, no. 2 (June 24, 2024): 89–96. http://dx.doi.org/10.53529/2500-1175-2024-2-89-96.

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Introduction. Allergy to birch pollen is a common allergic disease. The main allergen of birch pollen is Bet v 1. The Bet v 1 protein structure is the similar to proteins of hazel, alder and elm pollen, as well as fruits proteins (apples, apricots, peaches, cherries) and vegetables ones (carrots, celery). Therefore, children with an allergy to the Bet v 1 protein may experience oral allergy syndrome (OAS) and even anaphylaxis when eating these foods. Allergen-specific immunotherapy (ASIT) is the indication for the pollen allergy treatment.Presentation of the clinical case. A 11 years old child

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Knyziak-Mędrzycka, Izabela, Emilia Majsiak, and Bożena Cukrowska. "Allergic March in Children: The Significance of Precision Allergy Molecular Diagnosis (PAMD@) in Predicting Atopy Development and Planning Allergen-Specific Immunotherapy." Nutrients 15, no. 4 (2023): 978. http://dx.doi.org/10.3390/nu15040978.

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The allergic march is a progression of naturally occurring symptoms whose nature changes with age. The classic allergic march typically begins in infancy and manifests in the form of atopic dermatitis and food allergy. As immune tolerance develops over time, these conditions may resolve by the age of 3–5 years; however, they may evolve into allergic rhinitis and bronchial asthma. Traditional diagnostic assessments, such as skin prick testing or serum allergen-specific immunoglobulin E (sIgE) level testing, are conducted to introduce effective treatment. Recent years saw the emergence of precis

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Prilutskiy, O. S., and Yu A. Lyhina. "Allergy to lemon: case of oral allergic syndrome associated with allergic otitis media and labyrinthitis in a patient with polysensibilization and multiple manifestations of allergy." Russian Journal of Allergy 16, no. 2 (2019): 25–32. http://dx.doi.org/10.36691/rja1194.

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Oral allergic syndrome is an IgEmediated allergic reaction to foods of plant origin in persons with sensitization to various pollen allergens. A clinical case of oral allergy syndrome caused by consumption of lemon in a 25-year-old woman with sensitization to many groups of allergens and presence of allergic otitis media and allergy-induced labyrinthitis is presented. The patient had a history of seasonal allergic rhinoconjunctivitis, bronchial asthma, contact allergic dermatitis, urticaria as a manifestation of drug allergy. In vivo (skin prick tests, prick-prick tests) and in vitro allergen

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Białek, Sławomir, and Katarzyna Białek-Gosk. "Modern diagnosis of IgE-mediated allergy – molecular diagnosis of allergies." Diagnostyka Laboratoryjna 52, no. 1 (2016): 45–50. http://dx.doi.org/10.5604/01.3001.0008.9630.

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Diagnostic difficulties resulting from the imperfections of natural allergen extracts inspired to use genetic engineering techniques to produce recombinant allergens or obtaining highly purified components (component) allergen. This led to the development of modern diagnostic technique in allergy or molecular diagnostics. The basis for understanding the molecular diagnosis of allergies is to know the properties of allergens. Each allergen is composed of various proteins known. component capable of sensitizing allergen, and each component includes a plurality of epitopes that can be divided int

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Furrie, Elizabeth. "Probiotics and allergy." Proceedings of the Nutrition Society 64, no. 4 (2005): 465–69. http://dx.doi.org/10.1079/pns2005466.

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Allergy is caused by an immune reaction that is out of all proportion to the antigenic stimuli. Classical allergy is a type I hypersensitivity reaction mediated by the interaction of mast cells (and eosinophils) coated with allergen-specific IgE and a cross-linking allergen. The physiological outcome is inflammation commonly displayed by urticaria, rhinitis, vomiting and diarrhoea, depending on the route of allergen entry. In extreme reactions anaphylactic shock can result that may lead to death. Chronic allergic responses most commonly present themselves as asthma and eczema. All these sympto

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Chow, Timothy G., Christopher Parrish, and J. Andrew Bird. "Food allergy: Epicutaneous immunotherapy." Journal of Food Allergy 2, no. 1 (2020): 81–85. http://dx.doi.org/10.2500/jfa.2020.2.200016.

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The goal of allergen-specific immunotherapy for treatment of immunoglobulin E (IgE) mediated food allergy is to safely and effectively modify the allergic response, providing protection against anaphylaxis via ongoing exposure to the triggering allergen. Targeted allergen exposure via application of allergen to the epidermis has emerged as a potentially promising approach to desensitization. Epicutaneous immunotherapy (EPIT) uses allergen embedded on an adhesive patch secured to the skin. This allows for long-lasting allergen exposure, with subsequent antigen uptake and trafficking by skin ant

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Fouad, Shaimaa. "Incidence of Food allergy among patients with allergic conjunctivitis." Egyptian journal of Immunology 30, no. 04 (2023): 134–44. http://dx.doi.org/10.55133/eji.300414.

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The prevalence of ocular allergy is increasing worldwide. Skin prick test is widely recognized as the most reliable method for diagnosing the incriminating allergen as regards type I hypersensitivity reactions. Food allergy results as immunological response to food protein which leads to occurrence of allergic conjunctivitis (AC), allergic rhinitis, asthma, atopic dermatitis, and eosinophilic esophagitis. There is a scarcity of research investigating the association between food allergy and AC. This retrospective cohort study aimed to determine the incidence of food allergy within AC patients

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Kalm-Stephens, Pia, Therese Sterner, Kerstin Kronholm Diab, and Greta Smedje. "Hypersensitivity and the Working Environment for Allergy Nurses in Sweden." Journal of Allergy 2014 (April 6, 2014): 1–7. http://dx.doi.org/10.1155/2014/681934.

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Background. Allergy nurses are exposed to allergens and respiratory irritants, and there are no national guidelines addressing personnel safety when working with these agents. Objective. To investigate the prevalence of allergies, asthma, and hypersensitivity symptoms among allergy nurses and the use of protective equipment and measures when working with allergen concentrates and respiratory irritants. Methods. A questionnaire survey was performed among the members of the Swedish Association of Allergy Nurses. Results. Diagnosed asthma was reported by 17%, while 18% had allergy to pets, 28% ha

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Melnikova, Ksenya S., Elena D. Kuwshinowa, and Vera A. Reviakina. "Allergic diseases at an early age." Pediatrics. Consilium Medicum, no. 2 (June 15, 2021): 141–45. http://dx.doi.org/10.26442/26586630.2021.2.200813.

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In recent years, there has been a sharp increase in the incidence of allergic diseases (ADs), mainly in countries with a high level of development. Particularly noted is the increase in the prevalence of AZs in young children, among which cutaneous and gastrointestinal manifestations of allergy are the most common. These include atopic dermatitis (ATD), urticaria, gastrointestinal manifestations associated in most cases with food allergy, as well as contact allergic dermatitis, and insect allergy. The leading mechanism of development is immunoglobulin E (IgE)-mediated reactions. There are thre

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Pampura, A. N., E. F. Zhukalina, M. A. Morenko, and O. P. Ussenova. "Achievements and future prospects of molecular allergy diagnostics in pediatrics." Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) 70, no. 1 (2025): 5–10. https://doi.org/10.21508/1027-4065-2025-70-1-5-10.

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Improvements in clinical approaches and innovative technological solutions in the field of molecular allergy diagnostics have fundamentally changed the tactics and strategy for managing children with allergic diseases. In particular, molecular allergy diagnostics is used to make decisions in cases of suspected food allergy; to assess the risks of life-threatening reactions; to optimize the elimination diet; to identify cross-reactivity; to diagnose inhalant allergies and determine their clinical significance;to provide optimal recommendations for reducing the exposure to inhalation allergens;

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Graham, François, Susan Waserman, Jennifer Gerdts, Beatrice Povolo, Yvette Bonvalot, and Sébastien La Vieille. "A Survey of Allergic Consumers and Allergists on Precautionary Allergen Labelling: Where Do We Go from Here?" Nutrients 17, no. 9 (2025): 1556. https://doi.org/10.3390/nu17091556.

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Background: Despite the widespread use of precautionary allergen labelling (PAL) by manufacturers, PAL is not always used consistently and can be a source of misinterpretation by consumers and allergists. Although its use is not specifically regulated in Canada, some voluntary guidelines exist. The aims of this study were to investigate allergic consumers’ and clinicians’ understanding of PAL, to describe consumers’ attitudes towards products with PAL, and to examine recommendations given by clinicians to their patients about these products. We also compared two groups of consumers enrolled in

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Pampura, A. N., E. F. Zhukalina, M. A. Morenko, and O. P. Usenova. "Modern approaches to the diagnosis and management of children with allergy to cow’s milk proteins." Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) 68, no. 2 (2023): 39–46. http://dx.doi.org/10.21508/1027-4065-2023-68-2-39-46.

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Allergy to cow’s milk proteins is the most common cause of allergic reactions in young children, with a significant impact on the quality of life of children and their families. The most significant biomarker of herbivore milk allergy is allergen-specific IgE (sIgE), which can be assessed both for the whole allergen (for example, cow’s milk (CM), mare’s milk, goat’s milk, etc.) and a specific molecule, included in their composition. This article focuses on the use of sIgE in infants with suspected cow’s milk protein allergy.

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SALVATORE, S., K. KEYMOLEN, B. HAUSER, and Y. VANDENPLAS. "HYPO-ALLERGENIC INTERVENTIONS DURING PREGNANCY." Fetal and Maternal Medicine Review 17, no. 1 (2006): 23–43. http://dx.doi.org/10.1017/s0965539505001695.

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Baron Clemens von Pirquet, an Austrian paediatrician, proposed in 1903 the terms allergy and allergen after observing that some of his patients had “altered responses” to certain substances. Allergic symptoms are not necessarily accompanied by sensitization or vice versa. Recently, nomenclature for allergy has been revised.

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Choina, Magdalena, Weronika Gromek, Magdalena Marzęda, Khrystyna Lishchuk-Yakymovych, and Emilia Majsiak. "benefits of component-resolved diagnosis in diagnostics of peanut allergy." Journal of Education, Health and Sport 12, no. 7 (2022): 702–7. http://dx.doi.org/10.12775/jehs.2022.12.07.068.

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Introduction: Why can a peanut allergy cause exceptionally severe reactions, but not to everyone? Is there a way to identify patients who might experience these reactions? What is molecular diagnostics of allergy and what are the benefits of diagnosing patients at risk of anaphylaxis after consuming peanuts? Purpose: The aim of the study is to show the benefits of molecular diagnostics of allergies based on the example of peanut allergy.Description of the state of knowledge: The diagnosis of peanut allergy is based on the assessment of the clinical presentation. The gold diagnostic standard is

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Choudhary, Shazia, Mamoona Noreen, Muhammad Arshad, and Muhammad Arshad. "Pollen Allergy; Mechanism and Etiology." NUST Journal of Natural Sciences 1, no. 1 (2021): 16–19. http://dx.doi.org/10.53992/njns.v1i1.26.

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The term allergy refers to an exaggerated immune response to a foreign molecule. In a normal healthy individual, this foreign molecule will act as a harmless antigen, as it will be recognized & cleared by the immune system without causing any significant damage to host tissues. In certain individuals, such antigens stimulate immune system in such a way that a series of exaggerated immune response are generated against it, leading to significant tissue injury and damage to the host. Such as exaggerated immune response may also cause death of the patient. Such antigen is termed as an allerge

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El-Sayed, Zeinab A., Shereen S. El-Sayed, Rehab M. Zaki, and Mervat A. Salama. "Latex Hypersensitivity among Allergic Egyptian Children: Relation to Parental/Self Reports." Pulmonary Medicine 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/629187.

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Background. Latex allergy is one of the major health concerns and allergic reactions to latex may be serious and fatal.Purpose. In this study, we sought to determine the frequency of latex hypersensitivity in a group of allergic Egyptian infants and children and its relation to the history provided by the patients or caregivers.Methods. We consecutively enrolled 400 patients with physician diagnosed allergic diseases. The study measurements included clinical evaluation for the site and duration of allergy, history suggestive of latex allergy, family history of allergy, and skin prick testing (

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Nazaruddin, Nazaruddin, Hamdani Budiman, Basri A. Gani, Subhaini Jakfar, M. Hasan, and Muhammad Hanafiah. "PROFILE OF ALLERGY HYPERPLASMA PATHOLOGIC ANTIBODY AND IMMUNOGENIC CHARACTERISTIC." Jurnal Kedokteran Hewan - Indonesian Journal of Veterinary Sciences 11, no. 1 (2017): 35–38. http://dx.doi.org/10.21157/j.ked.hewan.v11i1.5299.

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The objective of this research was to determine the allergy hyperplasma pathologic antibody and to evaluate the immunogenic characteristics. Blood and serum were collected from human suffering rhinitis, skin, eye and asthma allergies. To obtain a cloned allergen plasma protein (protein allergen that had been induced with the serum from human with allergic rhinitis, skin, eye and asthma), the goat was used as an intermediate animal. Hematological analysis showed that the leukocyte cell such as neutrophil, lymphocyte, monocyte, and eosinophil increase in allergic-suffered human. The blood smear

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Adhianto, Gary, and Hendra S. "Clinical manifestations of allergic rhinitis in children at Denpasar Hospital." Paediatrica Indonesiana 41, no. 3 (2001): 160. http://dx.doi.org/10.14238/pi41.3.2001.160-5.

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This is a retrospective study by collecting data from the medical record of children diagnosed as allergic rhinitis at the Pediatric Allergy & Immunology out patient clinic at Denpasar Hospital between January 1996 and December 2000. Reported data including identifying patient, signs and symptoms, atopic history of the family, skin prick test (SPT) result and the environmental factors. Fifty-five from 297 children (18.5%) attending the Pediatric Allergy & Immunology out patient clinic were diagnosed as allergic rhinitis. Thirty nine were male and 16 female. The age ranged from 6 months

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Lodigiani, Claudia. "Analysis of Existing Treatment Methods for Cat Hair Allergy." Theoretical and Natural Science 97, no. 1 (2025): 119–23. https://doi.org/10.54254/2753-8818/2025.23287.

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Cat hair allergy is a common allergic reaction caused by Fel d 1, an allergen which can be found in the drooling, skin and sebaceous glands of cats. When allergic individuals inhale or come into contact with the protein, it triggers an immune system response that results in allergic reactions ranging from mild discomfort to severe respiratory symptoms. This paper explores three advanced approaches to address cat hair allergy, including analysis of the immunological role of Fel d 1, genetic engineering in order to reduce the production of the allergen in cats, and the application of monoclonal

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Rosada, Tomasz, Zbigniew Bartuzi, Magdalena Grześk-Kaczyńska, Magdalena Rydzyńska, and Natalia Ukleja-Sokołowska. "Treatment of Allergies to Fur Animals." International Journal of Molecular Sciences 25, no. 13 (2024): 7218. http://dx.doi.org/10.3390/ijms25137218.

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Allergy to fur animals is becoming an increasingly common clinical problem in everyday medical practice. Depending on the route of exposure to the allergen, patients present with many, often non-specific symptoms. The most common illnesses among people with allergies to the above-mentioned allergens are as follows: allergic rhinitis, allergic conjunctivitis, atopic bronchial asthma, food allergy, allergic contact dermatitis, and sometimes anaphylactic shock. In recent years, there has been a change in the holistic approach to the treatment of allergy patients. The method of treatment should be

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Barni, Simona, Davide Caimmi, Fernanda Chiera, et al. "Phenotypes and Endotypes of Peach Allergy: What Is New?" Nutrients 14, no. 5 (2022): 998. http://dx.doi.org/10.3390/nu14050998.

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Peach allergy is emerging as a common type of fresh-fruit allergy in Europe, especially in the Mediterranean area. The clinical manifestations of peach allergy tend to have a peculiar geographical distribution and can range from mild oral symptoms to anaphylaxis, depending on the allergic sensitization profile. The peach allergen Pru p 7, also known as peamaclein, has recently been identified as a marker of peach allergy severity and as being responsible for peculiar clinical features in areas with high exposure to cypress pollen. This review addresses the latest findings on molecular allergen

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Dityatkovska, E. M., and S. V. Biletska. "Determination of co-sensitization is an important step in improving the effectiveness of allergen-specific immunotherapy in patients with pollen disease." Medicni perspektivi 27, no. 1 (2022): 139–44. http://dx.doi.org/10.26641/2307-0404.2022.1.254379.

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In order to increase the effectiveness of allergen-specific immunotherapy in patients with pollen disease, the profile of allergen sensitization was determined at the molecular level, performed in 47 patients with clinical manifestations of seasonal rhinoconjunctivitis and perennial allergic rhinitis during a long time period. Allergic examination of patients included history taking, molecular blood tests using ALEX technology to determine the level of specific antibodies class lgE of major and minor components of pollen and household allergens and diagnostic skin tests (pre-test). Assessment

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Askhatova, Natalia A., Azat M. Alimov, Nadiya R. Kasanova, and Elena Y. Mikryukova. "Retrospective allergy diagnosis of lysteriosis and lysteria carrying in animals." BIO Web of Conferences 27 (2020): 00054. http://dx.doi.org/10.1051/bioconf/20202700054.

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Experimental infections of guinea pigs and rabbits with a sublethal dose of L. monocytogenes pathogen caused an allergic reaction in the form of delayed-type hypersensitivity (DTHS), which was detected by an intradermal allergy test with a Listeriose allergen. The status of DTHS in guinea pigs and rabbits was recorded for a longer time as compared to specific antibodies. A positive allergic reaction correlated with listeria, which was confirmed by the isolation of a Listeria culture 6 months after infection of rabbits with a virulent Listeria strain. The research findings showed that an intrad

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Galimova, Albina A., Svetlana S. Vyazankina, Svetlana G. Makarova, and Oksana A. Ereshko. "Active tolerance development in allergy to cow-based milk proteins." Russian Journal of Allergy 18, no. 4 (2021): 116–25. http://dx.doi.org/10.36691/rja1491.

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Food allergy is a potentially life-threatening condition without approved pathogenetic treatments other than eliminating the causal allergen and relief of acute allergic conditions. Immunoglobulin G-mediated form of food allergy remains a serious and growing problem worldwide. Its prevalence is steadily increasing and is a severe psychosocial and economic burden for patients and their families. Cow-based milk and products are important components of a childs diet, which are introduced at their first year of life, which can cause allergic reactions. The traditional management of children with c

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Prucha, Hanna, Wenchieh Chen, Claudia Traidl-Hoffmann, et al. "Atopic eczema and allergies: Practical relevance for diagnostic work-up." Community Based Medical Journal 2, no. 2 (2013): 15–24. http://dx.doi.org/10.3329/cbmj.v2i2.16693.

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Atopic eczema (AE) is a chronic relapsing skin disease mostly starting in childhood and often associated with allergic asthma and rhinoconjunctivitis. In the etiopathophysiology of atopic eczema skin barrier disturbance and immune deviation with a predominant Th2 response and IgE production are central. Allergy tests belong to the diagnostic work-up of AE patients, first in order to differentiate between the extrinsic (IgE-associated) from the intrinsic (non-IgE-associated) form of the disease. Essntially allergy tests are mandatory in order to find individual provocation factors for exace

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Biswas, Rakhi, Diviya Anish, Shobha Rani RH, et al. "Comprehensive Analysis of Allergens Exposure and Symptoms Onset for Allergic Conjunctivitis: A Retrospective Cohort Study." Ophthalmology Research: An International Journal 20, no. 4 (2025): 16–23. https://doi.org/10.9734/or/2025/v20i4462.

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Aims: This retrospective cohort study aims to assess the demographic characteristics, symptom progression, and allergen triggers in allergic conjunctivitis to provide insights for improved clinical management and preventive strategies. Study Design: Rretrospective Cohort Study. Place and Duration of Study: Bengaluru Allergy Center (BAC). Department of Allergy. March 2024 to May 2024. Methodology: Conducted at Bengaluru Allergy Center, the study involved 260 patients (169 patients were men, made up the majority; 91 patients were female) over six months. Data were analyzed for demographics, symp

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Lis, Kinga, and Zbigniew Bartuzi. "Selected Technical Aspects of Molecular Allergy Diagnostics." Current Issues in Molecular Biology 45, no. 7 (2023): 5481–93. http://dx.doi.org/10.3390/cimb45070347.

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Diagnosis of allergic diseases is a complex, multi-stage process. It often requires the use of various diagnostic tools. The in vitro diagnostics (IVD), which includes various laboratory tests, is one of the stages of this process. Standard laboratory tests include the measurement of the serum concentration of specific immunoglobulin E (sIgE) for selected allergens, full allergen extracts and/or single allergen components (molecules). The measurement of IgE sIgE to the allergen components is called molecular allergy diagnosis. During the standard laboratory diagnostic process, various models o

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Petrova, S. Yu, S. V. Khlgatian, V. M. Berzhets, and A. V. Vasileva. "Allergy vaccines for specific immunotherapy." Journal of microbiology, epidemiology and immunobiology 98, no. 1 (2021): 104–12. http://dx.doi.org/10.36233/0372-9311-11.

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Allergen-specific immunotherapy (ASIT) has been used for more than a hundred years to treat patients with IgEmediated allergic diseases. The most common allergens have been obtained using molecular cloning technology in the past two decades. To increase the safety of immunotherapy, a large group of genetically modified allergens with reduced allergenic activity was created. The mechanism of action of these therapeutic allergens differs from natural allergen extracts, and more research is needed to understand how desensitization occurs in each case. The objective of this review is to introduce

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Cook-Mills, Joan M., Lindsay M. Schroeder-Carter, and Nicole Ramos-Solís. "Maternal Alpha-tocopherol Inhibits Development of Food Allergy Early in Life." Journal of Immunology 204, no. 1_Supplement (2020): 66.18. http://dx.doi.org/10.4049/jimmunol.204.supp.66.18.

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Abstract Food allergy can be life-threatening and has had a marked recent increase in prevalence. Interventions are critical to limit the development of food allergy early in life. We demonstrate that maternal dietary supplementation with α-tocopherol blocks development of food allergy. Briefly, female mice received diet supplemented with α-tocopherol or control chow starting at mating with males with skin barrier gene mutations. The pups, that are heterozygous for skin barrier mutations, received six cutaneous co-exposures to a food allergen and an environmental allergen. Oral challenge with

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Riabova, Ksenja, Antonina V. Karsonova, Marianne van Hage, et al. "Molecular Allergen-Specific IgE Recognition Profiles and Cumulative Specific IgE Levels Associated with Phenotypes of Cat Allergy." International Journal of Molecular Sciences 23, no. 13 (2022): 6984. http://dx.doi.org/10.3390/ijms23136984.

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Cat allergy is a major trigger factor for respiratory reactions (asthma and rhinitis) in patients with immunoglobulin E (IgE) sensitization. In this study, we used a comprehensive panel of purified cat allergen molecules (rFel d 1, nFel d 2, rFel d 3, rFel d 4, rFel d 7, and rFel d 8) that were obtained by recombinant expression in Escherichia coli or by purification as natural proteins to study possible associations with different phenotypes of cat allergy (i.e., rhinitis, conjunctivitis, asthma, and dermatitis) by analyzing molecular IgE recognition profiles in a representative cohort of cli

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Dityatkovska, E.M., and S.V. Biletska. "Determination of co-sensitization is an important step in improving the effectiveness of allergen-specific immunotherapy in patients with pollen disease." Medicni perspektivi 27, no. 1 (2022): 139–44. https://doi.org/10.26641/2307-0404.2022.1.254379.

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In order to increase the effectiveness of allergen-specific immunotherapy in patients with pollen disease, the profile of allergen sensitization was determined at the molecular level, performed in 47 patients with clinical manifestations of seasonal rhinoconjunctivitis and perennial allergic rhinitis during a long time period. Allergic examination of patients included history taking, molecular blood tests using ALEX technology to determine the level of specific antibodies class lgE of major and minor components of pollen and household allergens and diagnostic skin tests (pre-test). Assessment

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Almeida, Flavia J., Jasmin Surana, Alap Christy, Raj Jatale, and Shibani Ramchandani. "Relevance of allergen specific immunoglobulin e testing in Indian population: A retrospective study." International Journal of Clinical Biochemistry and Research 10, no. 1 (2023): 2–13. http://dx.doi.org/10.18231/j.ijcbr.2023.002.

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Prevalence of allergies has increased dramatically in recent decade and is now considered major chronic disease at the global level. Measurement of total and allergen specific IgE (Immunoglobulin E) is often requested to assess possible allergy. The main objective of our study was to understand the relevance of allergen specific IgE testing in Indian population. This retrospective study was conducted at a Global Reference Laboratory in Mumbai from May 2020 to May 2022. Total available data of 65431 patients was included in the study. The data was sub grouped as per age group, gender, and posit

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Shogenova, M. S., S. H. Hutueva, L. S. Shogenova, and E. L. Muzhdabaeva. "Global climate warming and the expansion of ragweed – new problems in the spread of allergopathology, forecasts and prevention." ADYGHE INTERNATIONAL SCIENTIFIC JOURNAL 23, no. 2 (2023): 40–55. http://dx.doi.org/10.47928/1726-9946-2023-23-2-40-55.

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The article presents the main causes of the spread of ragweed pollen associated with global warming, describes the epidemiology, methods of control and prevention of pollen allergy, as well as modern principles of diagnosis and treatment of allergy to ragweed pollen. The main culprit of pollinosis is plant pollen. Clinical manifestations of allergy to ragweed pollen allergen are allergic rhinoconjunctivitis, bronchial asthma and, less often, contact dermatitis/urticaria. Up to 70% of patients with allergies to ragweed pollen react to products of the pumpkin family, as well as bananas, apple, a

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Baskakova, E. Yu, A. A. Tarasova, G. A. Savichev, et al. "Features of the course of pollen allergy in children in the Nizhny Novgorod region." Allergology and Immunology in Paediatrics, no. 2 (June 24, 2024): 50–59. http://dx.doi.org/10.53529/2500-1175-2024-2-50-59.

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Due to its widespread distribution, the problem of pollen allergy does not lose its relevance for practical healthcare: the variety of clinical forms, the possibility of polyvalent sensitization and pathogenetic treatment in the form of allergen-specific immunotherapy determine the importance of studying its clinical and epidemiological features.Materials and methods. A retrospective analysis of 119 discharge summaries of children with diagnoses of “Allergic rhinoconjunctivitis”, “Bronchial asthma”, “Atopic dermatitis”, occurring with clinically significant pollen sensitization, was carried ou

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Akdis, Mübeccel, Johan Verhagen, Alison Taylor, et al. "Immune Responses in Healthy and Allergic Individuals Are Characterized by a Fine Balance between Allergen-specific T Regulatory 1 and T Helper 2 Cells." Journal of Experimental Medicine 199, no. 11 (2004): 1567–75. http://dx.doi.org/10.1084/jem.20032058.

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The mechanisms by which immune responses to nonpathogenic environmental antigens lead to either allergy or nonharmful immunity are unknown. Single allergen-specific T cells constitute a very small fraction of the whole CD4+ T cell repertoire and can be isolated from the peripheral blood of humans according to their cytokine profile. Freshly purified interferon-γ–, interleukin (IL)-4–, and IL-10–producing allergen-specific CD4+ T cells display characteristics of T helper cell (Th)1-, Th2-, and T regulatory (Tr)1–like cells, respectively. Tr1 cells consistently represent the dominant subset spec

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Varshney, Pooja, and Jacqueline A. Pongracic. "Clinical manifestations of immunoglobulin E‐mediated food allergy, including pollen‐food allergy syndrome." Journal of Food Allergy 2, no. 1 (2020): 22–25. http://dx.doi.org/10.2500/jfa.2020.2.200002.

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Immunoglobulin E-(IgE) mediated food allergy affects people of all ages but does not have a consistent presentation and may result in various manifestations, even for an individual. The onset of symptoms is usually quite rapid, minutes to a few hours after consumption of the allergen, although exceptions exist. Cutaneous and gastrointestinal symptoms are the most common clinical manifestations; however, they are not present in all allergic reactions. Clinicians, particularly those in emergency care settings, need to be aware that the lack of cutaneous manifestations does not exclude the possib

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Zhang, Jihui, Jie Chen, Jie Zuo, et al. "Allergen Delivery Inhibitors: Characterisation of Potent and Selective Inhibitors of Der p 1 and Their Attenuation of Airway Responses to House Dust Mite Allergens." International Journal of Molecular Sciences 19, no. 10 (2018): 3166. http://dx.doi.org/10.3390/ijms19103166.

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Group 1 allergens of house dust mites (HDM) are globally significant triggers of allergic disease. They are considered as initiator allergens because their protease activity enables the development of allergy to a spectrum of unrelated allergens from various sources. This initiator-perpetuator function identifies Group 1 HDM allergens as attractive drug design targets for the first small-molecule approach directed towards a non-human, root cause trigger of allergic disease. The purpose of this study was to: (i) identify exemplar inhibitors of these allergens using Der p 1 as a design template,

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