Relevant bibliographies by topics / Allosteric modulators

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Allosteric modulators'

Author: Grafiati
Published: 4 June 2021
Last updated: 26 July 2025

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Journal articles on the topic "Allosteric modulators"

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Manetti, Dina, Silvia Dei, Hugo R. Arias, et al. "Recent Advances in the Discovery of Nicotinic Acetylcholine Receptor Allosteric Modulators." Molecules 28, no. 3 (2023): 1270. http://dx.doi.org/10.3390/molecules28031270.

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Positive allosteric modulators (PAMs), negative allosteric modulators (NAMs), silent agonists, allosteric activating PAMs and neutral or silent allosteric modulators are compounds capable of modulating the nicotinic receptor by interacting at allosteric modulatory sites distinct from the orthosteric sites. This survey is focused on the compounds that have been shown or have been designed to interact with nicotinic receptors as allosteric modulators of different subtypes, mainly α7 and α4β2. Minimal chemical changes can cause a different pharmacological profile, which can then lead to the desig
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Akimoto, Madoka, Karla Martinez Pomier, Bryan VanSchouwen, Jung Ah Byun, Mariia Khamina, and Giuseppe Melacini. "Allosteric pluripotency: challenges and opportunities." Biochemical Journal 479, no. 7 (2022): 825–38. http://dx.doi.org/10.1042/bcj20210528.

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Allosteric pluripotency arises when the functional response of an allosteric receptor to an allosteric stimulus depends on additional allosteric modulators. Here, we discuss allosteric pluripotency as observed in the prototypical Protein Kinase A (PKA) as well as in other signaling systems, from typical multidomain signaling proteins to bacterial enzymes. We identify key drivers of pluripotent allostery and illustrate how hypothesizing allosteric pluripotency may solve apparent discrepancies currently present in the literature regarding the dual nature of known allosteric modulators. We also o
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Langmead, Christopher J. "Screening for Positive Allosteric Modulators: Assessment of Modulator Concentration-Response Curves as a Screening Paradigm." Journal of Biomolecular Screening 12, no. 5 (2007): 668–76. http://dx.doi.org/10.1177/1087057107301854.

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Targeting allosteric binding sites represents a powerful mechanism for selectively modulating receptor function. The advent of functional assays as the screening method of choice is leading to an increase in the number of allosteric modulators identified. These include positive allosteric modulators that can increase the affinity of the orthosteric agonist and potentiate the evoked response. A common method for screening for positive allosteric modulators is to examine a concentration-response (C/R) curve to the putative modulator in the presence of a single, low concentration of agonist. The
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Homsher, Michelle F., Douglas C. Beshore, Jason Cassaday, et al. "High-Throughput Agonist Shift Assay Development for the Analysis of M1-Positive Allosteric Modulators." SLAS DISCOVERY: Advancing the Science of Drug Discovery 22, no. 8 (2017): 1060–66. http://dx.doi.org/10.1177/2472555217705373.

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Agonist shift assays feature cross-titrations of allosteric modulators and orthosteric ligands. Information generated in agonist shift assays can include a modulator’s effect on the orthosteric agonist’s potency (alpha) and efficacy (beta), as well as direct agonist activity of the allosteric ligand (tauB) and the intrinsic binding affinity of the modulator to the unoccupied receptor (KB). Because of the heavy resource demand and complex data handling, these allosteric parameters are determined infrequently during the course of a drug discovery program and on a relatively small subset of compo
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Goričan, Tjaša, and Simona Golič Grdadolnik. "Insights into the Allosteric Regulation of Human Hsp90 Revealed by NMR Spectroscopy." Biomolecules 15, no. 1 (2024): 37. https://doi.org/10.3390/biom15010037.

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Human heat shock protein 90 (Hsp90) is one of the most important chaperones that play a role in the late stages of protein folding. Errors in the process of the chaperone cycle can lead to diseases such as cancer and neurodegenerative diseases. Therefore, the activity of Hsp90 must be carefully regulated. One of the possibilities is allosteric regulation by its natural allosteric modulators—nucleotides, co-chaperones and client proteins—and synthetic small-molecule allosteric modulators, such as those targeting the middle domain or the C-terminal domain (CTD) of Hsp90. Since no experimentally
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Wang, Huiqun, Danni Cao, James C. Gillespie, et al. "Exploring the putative mechanism of allosteric modulations by mixed-action kappa/mu opioid receptor bitopic modulators." Future Medicinal Chemistry 13, no. 6 (2021): 551–73. http://dx.doi.org/10.4155/fmc-2020-0308.

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The modulation and selectivity mechanisms of seven mixed-action kappa opioid receptor (KOR)/mu opioid receptor (MOR) bitopic modulators were explored. Molecular modeling results indicated that the ‘message’ moiety of seven bitopic modulators shared the same binding mode with the orthosteric site of the KOR and MOR, whereas the ‘address’ moiety bound with different subdomains of the allosteric site of the KOR and MOR. The ‘address’ moiety of seven bitopic modulators bound to different subdomains of the allosteric site of the KOR and MOR may exhibit distinguishable allosteric modulations to the
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Trinh, Phuc N. H., Lauren T. May, Katie Leach, and Karen J. Gregory. "Biased agonism and allosteric modulation of metabotropic glutamate receptor 5." Clinical Science 132, no. 21 (2018): 2323–38. http://dx.doi.org/10.1042/cs20180374.

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Metabotropic glutamate receptors belong to class C G-protein-coupled receptors and consist of eight subtypes that are ubiquitously expressed throughout the central nervous system. In recent years, the metabotropic glutamate receptor subtype 5 (mGlu5) has emerged as a promising target for a broad range of psychiatric and neurological disorders. Drug discovery programs targetting mGlu5 are primarily focused on development of allosteric modulators that interact with sites distinct from the endogenous agonist glutamate. Significant efforts have seen mGlu5 allosteric modulators progress into clinic
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Żuk, Justyna, Damian Bartuzi, Andrea G. Silva, et al. "Allosteric modulation of dopamine D2L receptor in complex with Gi1 and Gi2 proteins: the effect of subtle structural and stereochemical ligand modifications." Pharmacological Reports 74, no. 2 (2022): 406–24. http://dx.doi.org/10.1007/s43440-021-00352-x.

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Abstract Background Allosteric modulation of G protein-coupled receptors (GPCRs) is nowadays one of the hot topics in drug discovery. In particular, allosteric modulators of D2 receptor have been proposed as potential modern therapeutics to treat schizophrenia and Parkinson’s disease. Methods To address some subtle structural and stereochemical aspects of allosteric modulation of D2 receptor, we performed extensive in silico studies of both enantiomers of two compounds (compound 1 and compound 2), and one of them (compound 2) was synthesized as a racemate in-house and studied in vitro. Results
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Christian, Catherine A., and John R. Huguenard. "Sniffer patch laser uncaging response (SPLURgE): an assay of regional differences in allosteric receptor modulation and neurotransmitter clearance." Journal of Neurophysiology 110, no. 7 (2013): 1722–31. http://dx.doi.org/10.1152/jn.00319.2013.

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Allosteric modulators exert actions on neurotransmitter receptors by positively or negatively altering the effective response of these receptors to their respective neurotransmitter. γ-Aminobutyric acid (GABA) type A ionotropic receptors (GABAARs) are major targets for allosteric modulators such as benzodiazepines, neurosteroids, and barbiturates. Analysis of substances that produce similar effects has been hampered by the lack of techniques to assess the localization and function of such agents in brain slices. Here we describe measurement of the sniffer patch laser uncaging response (SPLURgE
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Leach, Katie, Adriel Wen, Anna E. Cook, Patrick M. Sexton, Arthur D. Conigrave, and Arthur Christopoulos. "Impact of Clinically Relevant Mutations on the Pharmacoregulation and Signaling Bias of the Calcium-Sensing Receptor by Positive and Negative Allosteric Modulators." Endocrinology 154, no. 3 (2013): 1105–16. http://dx.doi.org/10.1210/en.2012-1887.

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Abstract Cinacalcet is predominantly used to treat secondary hyperparathyroidism due to end-stage renal failure, but, more recently, its potential clinical efficacy in treating patients with loss-of-function mutations in the calcium-sensing receptor (CaSR) has been recognized. Many clinically relevant CaSR mutations are located in the heptahelical membrane spanning and extracellular loop regions of the receptor, where allosteric modulators are predicted to bind. The aim of the present study was to investigate the impact of such mutations on the pharmacoregulation of the CaSR by the positive an
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Dissertations / Theses on the topic "Allosteric modulators"

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MACUT, HELENA. "DEVELOPMENT OF ALLOSTERIC PFKFB3 PHOSPHATASE MODULATORS." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/644064.

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Cardiovascular disease is a severe health problem, especially in the Western world. Its primary cause is atherosclerosis, which is characterized by the arterial wall thickening. Modern therapeutic strategies have restricted efficacy and the mortality still remains high. Current research has supported the idea of targeting dysregulated endothelial cell (EC) metabolism as a novel therapeutic strategy. In the scope of this PhD research work, we aim to further explore the possibilities for an improved treatment of this life threatening disease. EC glycolytic flux is up-regulated during angiogene
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Dhankher, P. "Synthesis of novel allosteric agonists and allosteric modulators for nicotinic acetylcholine receptors." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1417083/.

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In healthy individuals, the α7 and α4β2 nAChRs are concentrated in regions of the brain involved with learning, cognition and memory, which are relevant to diseases such as Alzheimer’s disease. Hence, these receptors have become significant from a pharmacological and drug discovery perspective. The tetrahydroquinoline compound 4BP-TQS has been reported to act as a potent allosteric agonist on the α7 nAChR. The natural product desformylflustrabromine is able to act as a positive allosteric modulator (PAM) on the α4β2 nAChR. This thesis describes the development of synthetic routes directed towa
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Alwassil, Osama. "Small Molecules as Negative Allosteric Modulators of Alpha7 nAChRs." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/2829.

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Alpha7 Neuronal nicotinic acetylcholine receptors (nAChRs) are involved in essential physiological functions and play a role in disorders such as Alzheimer’s disease. MD-354 (3-chlorophenylguanidine; 21), the first small–molecule negative allosteric modulator (NAM) at alpha7 nAChRs, served as a lead in developing structure–activity relationships for NAMs at a7 nAChRs. MD-354 (21) also binds at 5-HT3 receptors. Analogs of MD-354 with structural features detrimental to 5-HT3 receptor affinity were evaluated in patch-clamp recordings and an aniline N-methyl analog resulted in a more potent and se
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Alwassil, Osama I. "Elaboration and Design of α7 nAChR Negative Allosteric Modulators". VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3902.

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α7 Neuronal nicotinic acetylcholine receptors are one of two major classes of receptors responsible for cholinergic neurotransmission in the central nervous system. The existence of α7 neuronal nAChRs in different regions of the nervous system suggests their involvement in certain essential physiological functions as well as in disorders such as Alzheimer’s disease (AD), drug dependence, and depression. This project was aimed toward the discovery and development of small–molecule arylguanidines that modulate α7 nAChR function with improved subtype-selectivity through an allosteric approach. Id
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Myerson, Richard James. "The development of novel allosteric modulators of the 5-HT3 receptor." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7657/.

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This thesis reports the Structure Activity Relationship study that was performed upon the 5-substituted-indole core as a means to identify Negative Allosteric Modulators of the human 5-HT3A receptor for the development of potential drugs for the treatment of IBS-d. Herein is reported the successful identification of a PAM to NAM switch and three novel NAMs which provide the basis for further study into the treatment of IBS-d and insight into the identity of the allosteric site of the human 5-HT3A receptor. The design, synthesis and testing of a novel fluorescent analogue of the orthosteric ant
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Jackson, Doris Clark. "Characterization of Neuronal Nicotinic Acetylcholine Receptors and their Positive Allosteric Modulators." BYU ScholarsArchive, 2017. https://scholarsarchive.byu.edu/etd/6856.

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Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that are necessary in memory and cognition. They are pentameric and consist of α and β subunits. They are most commonly heteromeric but, can sometimes be homomeric. nAChRs are activated by many ligands including nicotine (exogenous) and acetylcholine (endogenous).nAChRs are located on hippocampal interneurons. The interneurons, although sparse, control the synchronous firing of the pyramidal cells. However, the hippocampal interneuron structure and function is quite diverse and not fully characterized. Therefor
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Abdelrahman, Mostafa Hamed. "Design, synthesis and SAR of novel allosteric modulators of the Cannabinoid CBI receptor." Thesis, University of Aberdeen, 2010. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=159203.

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We report on the design, synthesis, and structure activity relationship studies of novel Org 27569 analogues as potential allosteric modulators of the CB1 receptors. We also investigated by computer modelling the possible location of the allosteric site on CB1 and the binding confirmation of the allosteric ligands. Docking of the synthesised molecules is also performed and the results are compared to the results of the biological bioassays. The synthesis of non-fused indole analogues of Org 27569 is described. These analogues were systematically varied to study the importance of key functional
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Gómez, Santacana Xavier. "Design, synthesis and characterisation of photoswitchable allosteric modulators of metabotropic glutamate receptors." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/399789.

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Metabotropic glutamate receptors (mGlu receptors) are class C GPCRs widely distributed through the CNS and considered pharmacological targets for neurologic disorders, such as neuropathic pain and Parkinson’s disease, between others. Classical allosteric modulators receptors might be useful to treat these disorders, but they the control over of the compound, once it is administered, is lost. Photoswitchable allosteric modulators have an azo-­‐moiety in their chemical scaffold and might offer a powerful alternative to these classical drugs, since their pharmacological activity can be “switched
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Pagare, Piyusha P. "RATIONAL DESIGN OF ALLOSTERIC MODULATORS OF HEMOGLOBIN AS DUAL ACTING ANTISICKLING AGENTS." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5451.

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Intracellular polymerization of deoxygenated sickle hemoglobin (Hb S) remains the principal cause of the pathophysiology associated with sickle cell disease (SCD). Naturally occurring and synthetic allosteric effectors of hemoglobin (AEH) have been investigated as potential therapeutic agents for the treatment of SCD. Several aromatic aldehydes, including vanillin, have been studied previously as AEHs for their antisickling activities. Specifically, these compounds form Schiff- base adduct with Hb to stabilize the oxygenated (R) state, increase Hb affinity for O2 and concomitantly prevent the
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Young, G. T. "Molecular characterisation of nicotinic acetylcholine receptor subtypes : interactions with agonists and allosteric modulators." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/17315/.

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Nicotinic acetylcholine receptors (nAChRs) are members of the ligand-gated ion channel family. They are also members of the sub-family of Cys-loop ligandgated ion channels, which includes closely related receptors for the neurotransmitters γ-aminobutyric acid (GABA), glycine, and 5- hydroxytryptamine (serotonin). There is a wealth of evidence demonstrating that nAChRs are involved in mediating fast excitatory transmission, and also that they modulate the release of other neurotransmitters. They have been implicated in several neurological disorders such as Alzheimer’s disease, Parkinson’s dise
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Books on the topic "Allosteric modulators"

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Rees, Gayla, Benjamin Shapiro, and Matthew Torrington. Integrative Approach to Sedative-Hypnotic Use Disorder. Edited by Shahla J. Modir and George E. Muñoz. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190275334.003.0005.

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Sedatives, hypnotics, and anxiolytics are CNS depressants with GABAergic activity that are potentially habit-forming due to their activity in brain reward pathways. They are central in the drug overdose epidemic with benzodiazepines (BZD) being involved in approximately 31% of all fatal overdoses. There are 4 withdrawal syndromes: High dose minor and major withdrawal, low dose withdrawal, and protracted withdrawal. Benzodiazepines are chemically related positive allosteric modulators of the GABA at the GABA-A receptor. In differential expression 5 different receptor subunits play a role in acu
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Bejeuhr, Gesine. Synthese alloster wirksamer Modulatoren am muscarinergen M₂-Acetylcholin-Rezeptor. 1993.

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Scharfenstein, Olaf. Allostere Modulatoren des muskarinischen M2-Acetylcholinrezeptors: Variationen in den Seitenketten der Leitstruktur W84. 2000.

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Sürig, Ulf. Allostere Modulatoren muscarinerger Acetylcholinrezeptoren: Synthese und Struktur-Wirkungs-Beziehungen von Bisbenzylethern des TMB-4. 1994.

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Cid, Héctor Mario Botero. Synthese Allosterer Modulatoren der Muscarinergen Acetylcholin-Rezeptoren vom Duo-, W-Duo- und W-84-Typ. 1995.

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Book chapters on the topic "Allosteric modulators"

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Scherrmann, Jean-Michel, Kim Wolff, Christine A. Franco, et al. "Allosteric Modulators." In Encyclopedia of Psychopharmacology. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_1570.

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Gurney, Mark E., Alex B. Burgin, Olafur T. Magnusson, and Lance J. Stewart. "Small Molecule Allosteric Modulators of Phosphodiesterase 4." In Phosphodiesterases as Drug Targets. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-17969-3_7.

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Ni, Duan, Na Liu, and Chunquan Sheng. "Allosteric Modulators of Protein–Protein Interactions (PPIs)." In Advances in Experimental Medicine and Biology. Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-8719-7_13.

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He, Xinheng, Duan Ni, Shaoyong Lu, and Jian Zhang. "Characteristics of Allosteric Proteins, Sites, and Modulators." In Advances in Experimental Medicine and Biology. Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-8719-7_6.

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Gao, Zhan-Guo, Dilip K. Tosh, Shanu Jain, Jinha Yu, Rama R. Suresh, and Kenneth A. Jacobson. "A1 Adenosine Receptor Agonists, Antagonists, and Allosteric Modulators." In The Adenosine Receptors. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-90808-3_4.

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Bertekap, Robert L., Neil T. Burford, Zhuyin Li, and Andrew Alt. "High-Throughput Screening for Allosteric Modulators of GPCRs." In Methods in Molecular Biology. Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2914-6_15.

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Rodriguez, Alice L., and Colleen M. Niswender. "Technologies for Screening of mGlu Receptor Allosteric Modulators." In Neuromethods. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1107-4_1.

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Langmead, Christopher. "Screening for Allosteric Modulators of G Protein-Coupled Receptors." In GPCR Molecular Pharmacology and Drug Targeting. John Wiley & Sons, Inc., 2010. http://dx.doi.org/10.1002/9780470627327.ch12.

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Seifert, Roland. "Neuron Inhibitors with Pleiotropic Effects and Allosteric GABAAR Modulators." In Basic Knowledge of Pharmacology. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-18899-3_25.

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Urwyler, Stephan. "Allosteric Modulators: The New Generation of GABAB Receptor Ligands." In GABAB Receptor. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-46044-4_18.

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Conference papers on the topic "Allosteric modulators"

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Calejo, Ana, Henriette Andresen, Reza Parvan, et al. "Novel allosteric modulators of guanylyl cyclase A activity." In cGMP: Generators, Effectors and Therapeutic Implications. ScienceOpen, 2024. http://dx.doi.org/10.14293/cgmp.24000025.v1.

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Ullman, Elijah, Riley Perszyk, Jing Zhang, et al. "Unconventional Mechanisms of Novel Positive Allosteric Modulators of NDMA Receptors." In ASPET 2023 Annual Meeting Abstracts. American Society for Pharmacology and Experimental Therapeutics, 2023. http://dx.doi.org/10.1124/jpet.122.537050.

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Mannes, Morgane, Esaü Vangeloven, Charlotte Martin, et al. "Gq protein peptidomimetics as allosteric modulators of the ghrelin receptor." In 37th European Peptide Symposium. The European Peptide Society, 2024. http://dx.doi.org/10.17952/37eps.2024.p2253.

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Vo, Elizabeth Donohue, Gabriel Besserer Mercado, Patrick Alexander, et al. "Abstract 4018: Identifying allosteric modulators of KRas using second harmonic generation." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-4018.

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Nesterkina, Mariia, Alexandra Alexandrova, Elena Prokopchuk, and Iryna Kravchenko. "Synthesis and pharmacological properties of new GABA- and TRP allosteric modulators." In 1st International Electronic Conference on Medicinal Chemistry. MDPI, 2015. http://dx.doi.org/10.3390/ecmc-1-a017.

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Shpakov, Alexander. "THE ALLOSTERIC REGULATORS AND MODULATORS OF THE HETEROTRIMERIC G-PROTEINS-COUPLED RECEPTORS." In XVI International interdisciplinary congress "Neuroscience for Medicine and Psychology". LLC MAKS Press, 2020. http://dx.doi.org/10.29003/m1356.sudak.ns2020-16/540-541.

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Li, Mengchu, John Traynor, Sherrice Zhang, Matthew Stanczyk, Xinmin Gan, and Andrew White. "Structure-activity Exploration of Positive Allosteric Modulators of the Mu-opioid Receptor." In ASPET 2023 Annual Meeting Abstracts. American Society for Pharmacology and Experimental Therapeutics, 2023. http://dx.doi.org/10.1124/jpet.122.238420.

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Lei, Xia, Alice Rodriguez, and Colleen M. Niswender. "Profiling Context-Dependent Activity of Allosteric Modulators at mGlu7." In ASPET 2023 Annual Meeting Abstracts. American Society for Pharmacology and Experimental Therapeutics, 2023. http://dx.doi.org/10.1124/jpet.122.153810.

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Azmi, Asfar S., William Senapedis, Yosef Landesman, et al. "Abstract 1771: Novel small molecule pak4 allosteric modulators with activity against pancreatic cancer." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-1771.

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Grover, Prerna, and Thomas E. Smithgall. "Abstract 3728: A discovery platform for allosteric modulators of c-Abl kinase function." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-3728.

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