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Journal articles on the topic 'Alloxan-induced diabetic rats'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Ahamefula Sunday Ezekwe, Karibo Amakiri Okari, Peter Gift Wokocha, Mike Tochi Achor, and Boma Ngo Fubara. "Evaluating alloxan-induced diabetic rats." International Journal of Science and Research Archive 13, no. 2 (2024): 3544–52. https://doi.org/10.30574/ijsra.2024.13.2.2499.

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The increasing incidence of diabetes and the adverse effects of chemical medications underscore the importance of exploring alternative non-pharmacological treatments. Vernonia amygdalina, a widely utilized medicinal herb, shows promising therapeutic potential. This study investigated the impact of aqueous leaf extracts of Vernonia amygdalina on various biochemical parameters in alloxan-induced diabetic rats. Diabetes was induced in male Wistar rats through intraperitoneal injection of alloxan (150 mg/kg). The rats were then randomly divided into four groups: Group 1 (normal control), Group 2

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2

Farheen, Mehnoor, and Chakrapani Ramesh. "Phytochemical evaluation and pharmacological screening of ethanolic and aqueous leaf extracts of Pupalia lappacea for antihyperlipidemic and antihyperglycemic activities in alloxan induced diabetic Albino wistar rats." International Journal of Basic & Clinical Pharmacology 7, no. 4 (2018): 753. http://dx.doi.org/10.18203/2319-2003.ijbcp20181182.

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Background: Diabetes is associated with damage to the liver, pancreas and kidney. The damage may vary among patients. This study assessed the hypoglycaemic and antihyperlipidemic activities of leaves ethanolic and aqueous extracts of Pupalia lappaceae in alloxan induced diabetic albino wistar rats.Methods: There were Fifty four rats divided into nine groups containing six rats each. Group 1 consists of normal rats that were given only normal saline and served as a control group. Group 2 consists of normal rats that were given alloxan monohydrate (150mg/kg b.w). Group 3 consists alloxan induced

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3

Sultana, S., N. Y. Mili, R. Afroz, and S. Parveen. "Preventive Role of Zingiber Officinale against Hyperglycemia in Alloxan Induced Diabetic Rats." Journal of Medical Science & Research 30, Number 1 (2019): 26–29. http://dx.doi.org/10.47648/jmsr.2019.v3001.05.

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The experimental animal study was undertaken to investigate the preventive role ginger juice against hyperglycemia in alloxan induced diabetic rats.Male wistar rats,(130-150)gm wt fed on standard diet and water ad libitum, were divided into 3 groups(n=6) in each group: Group-L non-diabetic control group, Group-II, diabetic control & Group-III, normal rats pretreated with ginger before they were made diabetics. Diabetes was induced by inj. alloxan 150mg/kg body wt.,tp (Group-IL on 2nd day & Group-Ill, on the 9th day).Rats having blood glucose level of more than 7mmol/L on day 5(72 hours

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4

Chidinma, Iwuji Joy, Nwanjo Harrison Ugochukwu, Nwosu Dennis C, Osuegbu Mercy Chukwujindu, and Ohaeri Evangelina Ozoemena. "Comparative Assessment of Histopathological and Biochemical Indices of Renal Function in Alloxan-induced Male and Female Diabetic Rats." Asian Journal of Medicine and Health 22, no. 8 (2024): 106–16. http://dx.doi.org/10.9734/ajmah/2024/v22i81075.

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It has been observed that alloxan-induced diabetes causes free radical production, which ultimately damages the pancreatic β-cells and impact several organs especially the kidney. This study was a comparative assessment of histopathological and biochemical indices of renal function in alloxan-induced male and female diabetic rats. A total of twenty-four (24) male and female albino wistar rats were divided into five groups (6 rats per group): normal control female (group A), normal control male (group B), diabetic female (group C) and diabetic male (group D). Diabetes mellitus was induced in th

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5

Sultana, Selima, Shakil Akter, and Md Ismail Khan. "Anti-Hyperlipidemic Action of Zingiber officinale (Ginger) Juice in Alloxan Induced Diabetic Rats." Ibrahim Medical College Journal 6, no. 2 (2013): 55–58. http://dx.doi.org/10.3329/imcj.v6i2.14730.

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Hyperlipidemia is an important modifiable risk factor contributing to atterosclerosis in diabetes mellitus. Zingiber officinale (ginger) widely consumed as spice is known for its hypoglycemic and hypochlosteremic actions. The present study was undertaken to investigate anti-hyperlipidemic action of ginger juice in alloxan-induced diabetic rats. Male Wister rats, 130-150 g wt, fed on standard diet and water ad libitum were divided into 4 groups (n=6 in each group): group I nondiabetic control, group II non-diabetic treated; group III diabetic control and group IV diabetic treated. Diabetes was

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6

Thilagam, Ellappan, Kumarappan Chidambaram, Chinthamreddy Raviteja, Thalu Vahana, and Parameshwaran Vasudevan. "Anti-hyperglycemic and hypolipidemic effects of Saraca asoca (Roxb.) Wild. flowers in alloxan-treated diabetic rats." Journal of Pharmacy & Pharmacognosy Research 9, no. 1 (2021): 58–68. http://dx.doi.org/10.56499/jppres20.894_9.1.58.

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Context: Saraca asoca (Leguminosae) has been widely used in the Ayurvedic system of medicine for various ailments, and it has been used to treat diabetes as a folk medicine. Aims: To investigate the anti-hyperglycemic and anti-hyperlipidemic effect of ethanolic extracts of S. asoca (EESA) flowers in alloxan-induced diabetic rats. Methods: The anti-hyperglycemic activity of EESA was evaluated by using normal and alloxan-induced (120 mg/kg, i.p.) diabetic rats. In the sub-chronic animal model of diabetes mellitus, EESA was orally administered to normal and alloxan-induced-diabetic rats at doses

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7

Ekinci, Bilge, Bahadir Suleyman, Renad Mammadov, et al. "The effect of carvacrol upon experımentally ınduced dıabetıc neuropathy and neuropathıc paın ın rats." Acta Poloniae Pharmaceutica - Drug Research 79, no. 5 (2023): 707–15. http://dx.doi.org/10.32383/appdr/155354.

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Diabetic neuropathies are the most frequent complication of diabetes. While numerous metabolic pathways are disrupted in diabetic neuropathy, oxidative stress has been indicated as a significant reason for this condition. In this study, the effect of carvacrol, which has antioxidant effects, on experimental diabetic neuropathy and neuropathic pain was investigated. Alloxan was used to induce diabetes in the experiment. Diabetes was created by administering 120mg/kg of alloxan intraperitoneally (i.p) once a day for 3 days. Rats with a blood glucose concentration above 250mg/kg in the blood take

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8

Hussaini, SMAK, MI Hossain, MS Islam, and K. Rafiq. "Effects of Spirulina platensis on alloxan induced diabetic rats." Progressive Agriculture 29, no. 2 (2018): 139–46. http://dx.doi.org/10.3329/pa.v29i2.38300.

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The study was undertaken to investigate the effects of Spirulina platensis on body weight, blood glucose and lipid profile on alloxan induced diabetic rats. Fifteen Long Evans male rats at six weeks of age were used for the experiment. Diabetes was induced by intraperitoneal injection of alloxan@ 150 mg/kg and experiment was carried out for a period of 6 weeks. Rats were divided into three groups of 5 rats each. The groups were i)healthy control, ii) diabetic control with both receiving rats’ pellet as supplement, and iii) diabetic treated with oral administration of Spirulina platensis @ 400

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9

Gu, Peng-Cheng, Lan Wang, Mei-Na Han, et al. "Comparative Pharmacokinetic Study of Mangiferin in Normal and Alloxan-Induced Diabetic Rats after Oral and Intravenous Administration by UPLC-MS/MS." Pharmacology 103, no. 1-2 (2018): 30–37. http://dx.doi.org/10.1159/000493364.

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Backgrounds: Diabetes mellitus (DM)-induced morphological and/or functional complications may alter the pharmacokinetic profiles of mangiferin. This study aims to compare pharmacokinetic profiles of mangiferin in normal and alloxan-induced diabetic rats after oral and intravenous administration. Methods: Mangiferin was administered orally (10 mg/kg) and intravenously (2 mg/kg) to normal and alloxan-induced diabetic Sprague-Dawley (SD) rats (n = 8). Blood samples were collected at different time points post-dose. Mangiferin and esculentoside (internal standard) were analyzed by Waters Acquity u

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10

Rahman, AFM Towheedur, Md Saiful Islam, Md Hazrat Ali, et al. "Nigella sativa Oil Potentiates the Effects of Pioglitazone on Long Term Alloxan-Induced Diabetic Rats." Bangladesh Pharmaceutical Journal 16, no. 2 (2015): 143–51. http://dx.doi.org/10.3329/bpj.v16i2.22296.

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The present study was designed to investigate the effects of combination of Nigella sativa oil and pioglitazone on long-term alloxan-induced diabetic rats. In short-term (two weeks) alloxan-induced diabetic rats, N. sativa oil (NSO) reduced significant amount of glucose in blood, TC, TG and LDL-C and increased significant amount of HDL-C compared to diabetic rats. However, pathological changes of pancreass Islets of Langerhans were observed after long-term (four weeks) induction of alloxan in rats. Administration of NSO recovered Langerhans cells from shrinkage whereas pioglitazone displayed

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Simorangkir, Murniaty, Erlintan Sinaga, and Saronom Silaban. "HEPATOPROTECTIVE AND HISTOLOGICAL PANCREAS EFFECTS OF Sarang Banua (Clerodenrum fragrans Vent Willd) LEAF EXTRACT IN ALLOXAN-INDUCED DIABETIC RATS." RASAYAN Journal of Chemistry 15, no. 03 (2022): 1846–54. http://dx.doi.org/10.31788/rjc.2022.1536979.

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Research on anti-diabetic herbal plants and their safety continues to grow by the increasing number of diabetics, especially in Indonesia, which is rich in plant biodiversity. This study investigated the effect of Sarang banua (Clerodendrum fragrans Vent Willd) leaf extract on the hepatoprotective effect, histology of the pancreas, and serum glucose levels of white male rats (Rattus novergicus) induced diabetes by alloxan. Diabetic rats were given ethanol extract of C. fragrans leaf (100, 200, and 300 mg/kg bw), ethyl acetate extract (200, 300 mg/kg bw), and metformin (125 mg/kg) orally for 14

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Stalin, Chandrasekeran, V. Gunasekaran, and G. Jayabalan. "Evaluation of Neuroprotective Effect of Ficus benghalensis against Alloxan Induced Diabetic Neuropathy in Rats." International Journal of Pharmacology, Phytochemistry and Ethnomedicine 4 (August 2016): 52–60. http://dx.doi.org/10.18052/www.scipress.com/ijppe.4.52.

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Neuropathic pain in diabetics is characterized by both hyperalgesia and allodynia. This is attributed to both uncontrolled glycemia and the further complications which it leads to. The objective of the study was to evaluate the neuroprotective effect of methanolic leaf extract of Ficus benghalensis against alloxan induced diabetic neuropathy in rats.Material and methods:Experimental diabetes was induced in wistar albino rats by single intraperitoneal injection of Alloxan monohydrate (150 mg/kg). The methanolic extract of leaves of Ficus benghalensis at a dose of 200 and 400 mg/kg body weight w

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13

Akuodor, Godwin Christian, Pius Monday Udia, Sylvester Chika Ohadoma, et al. "Antihyperglycaemic and haematological effects of ethanol extract of Salacia lehmbachii leaf in alloxan-induced diabetic Wistar rats." Journal of Herbmed Pharmacology 10, no. 4 (2021): 394–400. http://dx.doi.org/10.34172/jhp.2021.46.

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Introduction: Salacia lehmbachii is used traditionally for the treatment of diabetes mellitus. This study investigated the hypoglycaemic potentials of ethanol leaf extract of S. lehmbachii and its effects on alloxan-induced diabetic rats’ haematological parameters. Methods: A total of 36 male Wistar rats including normal, diabetic untreated, and diabetic treated ones were used in this study. Diabetes was induced by a single intraperitoneal injection of 150 mg/kg of alloxan. When confirmed diabetes, the rats were orally administered 100 mg/kg, 200 mg/kg, and 400 mg/kg daily of the leaf extract

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Tyagi, C. K., Pawan Porwal, Neeraj Mishra, et al. "Antidiabetic Activity of the Methanolic Extracts of Thuja occidentalis Twings in Alloxan-induced Rats." Current Traditional Medicine 5, no. 2 (2019): 126–31. http://dx.doi.org/10.2174/2215083805666190312153743.

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Objective and Background: In hyperglycemic and alloxan-induced diabetic rats, the effect of Thuja occidentalis methanolic residue extract on blood glucose levels and some biochemical parameters were investigated. Methods: Significantly decreased blood glucose level by 22.85% and 27.66%, in hyperglycemic rats, respectively after 3 h, were seen in a single oral administration of the extract at a dose of 200 and 400 mg/kg. Blood glucose level was decreased by 50% in alloxan-induced diabetic rats within three weeks of daily treatment of Thuja occidentalis methanolic residue extract (200 and 400 mg

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K., Ahmed S., Chakrapani Cheekavolu, Naveen Alasyam, and Sunil M. "Evaluation of antidiabetic potential of hydroalcoholic extract of Annona squamosa (HAEAS) leaf in alloxan monohydrate induced diabetic Albino rats." International Journal of Basic & Clinical Pharmacology 7, no. 1 (2017): 179. http://dx.doi.org/10.18203/2319-2003.ijbcp20175696.

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Background: Diabetes is almost growing health concern worldwide and now emerging as an epidemic world over. Recently, full attention is being paid to the study of natural products as potential antidiabetics. Objective of the study was to evaluate the antidiabetic effect of hydroalcoholic leaf extract of Annona squamosa (HAEAS) plant in alloxan monohydrate induced diabetic albino rats.Methods: Almost a 30 Albino rats with 150- 200 grams weight were weighed and grouped into 5 equal groups taking 6 rats in every group. Group A served as normal control, Group B as diabetic control, received alloxa

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Chinnappan A Kalpana and R.Abraham. "Anti- hyperglycemic activity of polyherbal formulation (Herbinsulplus) in experimental diabetes and its effects on key metabolic enzymes of carbohydrate metabolism." JOURNAL OF ADVANCED APPLIED SCIENTIFIC RESEARCH 3, no. 6 (2021): 12–20. http://dx.doi.org/10.46947/joaasr362021138.

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Diabetes mellitus is a metabolic disorder in which the body does not produce or properly utilize insulin, causes disturbances in carbohydrate, protein and lipid metabolism. In spite of the presence of series of known anti-diabetic medicine in the pharmaceutical market, remedies from medicinal plants are used with success to treat this disease. The investigation was undertaken to study the effect of polyherbal formulation on changes in Body weight, Plasma glucose, RBC, WBC, HB, Platelets, Hepatic glucokinase & hexokinase, Glucose-6-phosphate and Glycogen content. In the current study, diabe

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Onoja, Uwakwe S., Cynthia C. Ugwu, Philip F. Uzor, et al. "Effect of Anogeissus leiocarpus Guill and Perr Leaf on Hyperglycaemia and Associated Dyslipidaemia in Alloxan-induced Diabetic Rats." Dhaka University Journal of Pharmaceutical Sciences 17, no. 1 (2018): 65–72. http://dx.doi.org/10.3329/dujps.v17i1.37120.

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People living with diabetes mellitus across the world are expected to rise to 592 million by 2035 and the pandemic disease is worst in the developing countries like Nigeria, where the cost of treating/managing diabetes mellitus is relatively out of the reach of many diabetic patients. The study investigated the effect of Anogeissus leiocarpus Guill and Perr ethanolic leaf extract on blood glucose and other biochemical indices in alloxan-induced diabetic adult male Wistar albino rats. Diabetes mellitus was induced in overnight-fasted rats by a single intraperitoneal injection of alloxan monohyd

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MUHAMMADU, Aliyu shaiskawa, Atabo Isaac ATOKOLO, Anita Charlotte JITE, et al. "Effects of Methanolic Extracts of Anisopus mannii Leaves on Blood Glucose and Organ Weights of Wistar Rats with Alloxan Induced-Diabetes." Journal of Biochemistry and Molecular Biology 2, no. 1 (2024): 23–31. http://dx.doi.org/10.36108/jbmb/4202.20.0130.

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This study looked at the impact of Anisopus mannii methanolic leaf extract on Wistar rats’ organ weights and alloxan-induced diabetes. For this investigation, a total of 20 male Wistar (albino) rats weighing between 80 and 150 g were used. Four groups of rats were randomly assigned. 1: Normal control; 2: Negative control; 3: Positive control (treated alloxan induced-diabetic with 5 mg/kg metformin); 4: alloxan induced-diabetic treated with 200 mg/kg of methanolic A. mannii leaf extract. The findings of the study show there was a significant difference in the blood glucose levels between the di

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Prajawanti, Kadeq Novita, Yohanes Ardian Kapri Negara, Intan Febiola Arianing та Fitri Junitasari. "Antidiabetic and TNF-α Lowering Effect of Tagetes erecta Extract in Alloxan-Induced Diabetic Rats". Borneo Journal of Pharmacy 8, № 2 (2025): 184–93. https://doi.org/10.33084/bjop.v8i2.6871.

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Diabetes mellitus is a chronic metabolic disorder characterized by impaired insulin production or action, often leading to pancreatic β-cell dysfunction and apoptosis. Pro-inflammatory cytokines, notably Tumor Necrosis Factor-alpha (TNF-α), play a critical role in the pathogenesis of type 2 diabetes (T2D). While Tagetes erecta (marigold) has demonstrated potential in lowering blood glucose in hyperglycemic conditions, its anti-inflammatory effects in diabetic models remain underexplored. This study aimed to evaluate the antidiabetic and TNF-α lowering effects of T. erecta extract in alloxan-in

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Derouiche, Samir, Djermoune Manel, and Abbas Kawther. "Beneficial Effect of Zinc on diabetes induced kidney damage and liver stress oxidative in rats." JOURNAL OF ADVANCES IN BIOLOGY 10, no. 1 (2017): 2050–55. http://dx.doi.org/10.24297/jab.v10i1.6022.

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The present study was designed to investigate the effects of Zn supplementation on kikney function and liver oxidative stress in Alloxan diabetic rats. Male albino Wistar rats were randomly divided into 4 groups (n=10): Control, Non Diabetic + zinc, Diabetic and Diabetic + Zinc. Diabetes was induced by alloxan (150 mg/kg). Zinc (231 mg/kg feed) as ZnSO4 7H2O was added to the feed of the animals in the zinc groups for 21 days. Alloxan Diabetes caused a significant decrease in body weight gain, serum and tissue zinc, serum protein concentrations, liver GSH, GPx and GST activities .In contrast, i

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Omoboyowa, D. A., F. O. Afolabi, and T. C. Aribigbola. "Pharmacological potential of methanol extract of Anacardium occidentale stem bark on alloxan-induced diabetic rats." Biomedical Research and Therapy 5, no. 7 (2018): 2440–54. http://dx.doi.org/10.15419/bmrat.v5i7.456.

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Background: The anti-hyperglycemic potential of methanol stem bark extract of Anacardium occidentale (MSBEAO) was investigated using an alloxan-induced diabetic rat model. Alloxan administration induces the generation of free radicals which can affect antioxidant status resulting in the disruption of the β-cells of the pancreas. Therefore, this study examines the antioxidant potential of the plant extract and the ameliorating effect on the pancreas of alloxan-induced diabetic rats. Methods: Diabetes was induced by intraperitoneal injection of 150 mg/kg body weight of alloxan monohydrate.

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Kingsley Chimsorom Chilaka, Amarachi Chioma Opara, Ugochinyere Jane Chilaka, Godwin Christian Akuodor, Mansur Aliyu Ramalan, and Ekene Enekabokom Nwoke. "Comparative effects of combinations of metformin, omega-3 and omega-6 oil in the treatment of alloxan-induced diabetic rats." Magna Scientia Advanced Biology and Pharmacy 6, no. 1 (2022): 016–32. http://dx.doi.org/10.30574/msabp.2022.6.1.0066.

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Emerging evidence suggests beneficial effects of omega fatty acids on diabetic complications. This study was designed to investigate the impact of Omega-3 and Omega-6 oil in the management of oxidative stress associated with complications in diabetes in alloxan induced diabetic rats. Experimental rats used in this study were grouped into four as non-diabetics and untreated, alloxan induced diabetic group, alloxan induced and treated with Metformin, lloxan induced and administered Metformin + Omega-3, alloxan induced and administered Metformin + Omega-6 oil. Effect of Metformin + Omega-3 and Me

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Navneet, Sharma, and Goyal Anju. "Hypoglycemic Effect of Polyherbal Formulation in Alloxan Induced Diabetic Rats." Chemistry Research Journal 2, no. 4 (2017): 214–19. https://doi.org/10.5281/zenodo.13954661.

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Diabetes is a leading cause of morbidity and mortality in the world. There is currently an active search for antidiabetic drugs with greater effectiveness with fewer and less adverse side effects. Therefore, in present study the hypoglycemic potential of polyherbal formulation was investigated in alloxan induced diabetic rats. A list of medicinal plants with proven antidiabetic and related beneficial effects of herbal drugs used in treatment of diabetes is compiled. These include <em>Gymnema sylvestre, Syzygium cumini, Trigonella foenum- graecum, Azadirachta indica, Momordica charantia, Curcum

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Bulbul, Israt Jahan, Umma Shafia Joty, Ridoy Ahamed, Mohammad Rashedul Haque, and Mohammad A. Rashid. "Hypoglycemic and Hypolipidemic Activities of Psychotria sylhetensis Hook in Alloxan-induced Type 2 Diabetic Rats." Bangladesh Pharmaceutical Journal 22, no. 1 (2019): 41–44. http://dx.doi.org/10.3329/bpj.v22i1.40071.

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The current study was carried out to determine the hypoglycemic and hypolipidemic activities of methanolic extract P. silhetensis leaves in alloxan-induced diabetic rats. In this study diabetes was induced in rats by intraperitoneal administration of 150 mg/kg of alloxan. Animals were treated for one week with the plant extract at doses of 250 and 500 mg/kg body weight. Metformin (100 mg/kg b.w.) was used as standard for comparison. The anti-diabetes activity was examined by measuring blood glucose level at 0, 3, 5 and 7 days in diabetic induced animal models. Blood samples were collected at d

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Hidayati, Sri Hidayati. "EFFECT OF DUKU (Lansium domesticum Corr) SEED EXTRACT ON URINATION ALLOXAN INDUCED DIABETIC RATS." Majalah Kedokteran Sriwijaya 53, no. 3 (2022): 82–91. http://dx.doi.org/10.32539/mks.v53i3.15576.

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ABSTRACT Duku seed extract has hypoglycemic effect. The result of phytochemical screening showed the presence of flavonoid, triterpen and saponin. To determine the effect, the clinical trial was carried out on alloxan induced diabetic rats. The aims of study is to determine of effect duku seed extract to urination on alloxan induced diabetic rats. Experimental study with pre-and post-test with control group design was carried out at Laboratory Chemistry Analysis MIPA Faculty and Animal House at Faculty of Medicine Sriwijaya University University in January 2014 to March 2014. The study subject

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Md., Faheemuddin. "Evaluation of Anti-Diabetic Activity of the Plant Leaves of Verbascum thapsus in Alloxan Induced Diabetic Rats." International Journal of Pharmaceutics & Pharmacology 1, no. 4 (2018): 118. https://doi.org/10.5281/zenodo.1161076.

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Objective: To evaluate the anti-diabetic activity of ethanolic extract of Verbascum thapsus (L) on alloxan induced diabetic rats.  Methods: Diabetes was induced in Wistar rats by intraperitoneal injection of alloxan monohydrate (100 mg/kg b.w/i.p). Ethanolic extract of Verbascum thapsus (L) (250, 500 mg/kg b.w/p.o) was prepared freshly,  administered to alloxan induced diabetic rats for 21 days. Blood glucose levels monitored at 1, 3, 7, 14 and 21 days, serum lipid profile and Histopathological changes in pancreas were examined after 21 days. OGTT was performed by administration of 2

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Ojewale, A. O., H. B. Akpan, F. A. Faduyile, P. D. Shallie, A. A. Akande, and A. K. Adefule. "Hepatoprotective Activities of Ethanolic Roots Extract of Ageratum Conyzoides on Alloxan-Induced Hepatic Damage in Diabetic Wistar Rats." Journal of Morphological Sciences 36, no. 01 (2018): 039–45. http://dx.doi.org/10.1055/s-0038-1669423.

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Introduction The aim of the present study was to evaluate the hepatoprotective activities of the ethanolic roots extract of Ageratum conyzoides (AC) in alloxan-induced hepatic damage in diabetic rats. Materials and Methods Diabetes was induced in Wistar rats by the administration of alloxan (150 mg/kg, intraperitoneal). The ethanolic roots extract of AC, at doses of 250 and 500 mg/kg of body weight, was administered to diabetes-induced rats at a single dose per day for a period of 28 days. Results The effect of the ethanolic roots extract of AC on blood glucose, alanine aminotransferase (ALT),

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El-Gamal, El-Khedr Mohamed Mostafa. "Therapeutic Benefits of Garlic against Alloxan-Induced Diabetic in Rats." Journal of Medical Science And clinical Research 05, no. 02 (2017): 17445–53. http://dx.doi.org/10.18535/jmscr/v5i2.39.

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Ramkumar, KM, RS Vijayakumar, P. Vanitha, et al. "Protective effect of gallic acid on alloxan-induced oxidative stress and osmotic fragility in rats." Human & Experimental Toxicology 33, no. 6 (2013): 638–49. http://dx.doi.org/10.1177/0960327113504792.

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In the present study, we investigated the antioxidant effect of gallic acid (GA) on membrane lipid peroxidation and osmotic fragility in alloxan-induced diabetic Wistar rats. GA was administered orally at doses of 5, 10, and 20 mg/kg body weight for 45 days, after which liver and kidney tissues were analyzed for the degree of lipid peroxidation, reduced glutathione, and the activities of antioxidants such as catalase, superoxide dismutase, and glutathione peroxidase. Administration of GA to alloxan-induced diabetic rats reduced the blood glucose level with an increase in the level of insulin.

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Okvenda, Ariani Zaltin, Eti Yerizel, and Raveinal. "Olive oil increase catalase activity and gluthatione peroxidase level in hyperglycemic rats." Acta Biochimica Indonesiana 6, no. 2 (2023): 137. http://dx.doi.org/10.32889/actabioina.137.

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Background: Diabetes mellitus is the most common endocrine disease globally. Hyperglycemia in diabetes mellitus is known to trigger oxidative stress. The activity of glutathione peroxidase (GSH-Px) is decreased in diabetic conditions. Catalase activity acts as a defense system to prevent the formation of free radicals (oxidants) in the human body. Objective: This study aimed to determine the effectiveness of olive oil antioxidants on catalase activity and GSH-Px levels in hyperglycemic rats. Methods: Adult male Wistar rats were randomized into three groups (n: 8): untreated control (Control),

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Kankara, Idris Aliyu, Akos Noel Ibrahim, and Haruna Ade. "Hepatocurative Effect of Some Ethnomedicinal Plants on Liver Function Indices in Alloxan- Induced Diabetic Rats." Asian Journal of Research in Biochemistry 12, no. 1 (2023): 1–7. http://dx.doi.org/10.9734/ajrb/2023/v12i1223.

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Aims: This research investigated the curative effects of Moringa oleifera (MO), Treculia africana (T.A.), and Albizzia chevalieri (A.C.) plant extracts on the liver function indices in Alloxan-induced diabetic rats. Study Design: Albino rats were grouped into five (5) main groups MO, TA, A.C., Normal Control (N.C.), and Diabetic Control (D.C.) groups. Place and Duration of Study: Department of Science Laboratory Technology, Federal Polytechnic Kaura Namoda, between May 2021 and July 2021. Methodology: Diabetes mellitus was caused by a single dose intraperitoneal injection of

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Fazal, Jaweria, Lubna Naz, Sumera Sohail, Ghazala Yasmeen, Nazish Iqbal, and Nazneen Zehra. "Anti-diabetic activity of Carica Papaya Linn in Alloxan-Induced diabetic rats." International Journal of Endorsing Health Science Research (IJEHSR) 10, no. 1 (2022): 42–48. http://dx.doi.org/10.29052/ijehsr.v10.i1.2022.42-48.

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Background: Type I Diabetes Mellitus (TIDM) is a disease known to occur in any age group, but most of the people affected are diagnosed in their mid-teenage. It is marked by hyperglycemia due to autoimmune destruction of insulin-producing pancreatic beta cells. Herbal treatment of DM has attracted attention in the last few decades because of its ability to improve diabetic complications such as nephrotic deterioration and oxidative stress. The present research is sought to determine the anti-diabetic potential of Carica Papaya leaf extract in Alloxan-induced diabetic rats. Methodology: F

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Kumar, Sanjeev, N. K. Prasad, and Kumari Shachi. "Therapeutic Efficacy of Ficus Glomerata Leaves in Alloxan Monohydrate Induced Type-1 Diabetes in Albino Rats." Endocrinology and Disorders 5, no. 4 (2021): 01–02. http://dx.doi.org/10.31579/2640-1045/077.

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Present study was aimed to evaluate the anti-diabetic efficacy of Ficus glomerata in Alloxan monohydrate induced albino rats. Oral administration of fresh Ficus glomerataleaves (2 - 4 g/day) for 60 days shows significant blood glucose lowering effect in experimental alloxan induced diabetic rats. These diabetic rats blood glucose level became normal when fed with Ficus glomerata leaves. It is amply revealed that fresh Ficus glomerata indica leaves possessed anti-diabetic properties. The results suggest that statistically significant anti-diabetic potential in alloxan monohydrate induced diabet

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Osigwe, Chinyelu C., Peter A. Akah, Chukwuemeka S. Nworu, and Festus B. C. Okoye. "Apigenin: A methanol fraction component of Newbouldia laevis leaf, as a potential antidiabetic agent." Journal of Phytopharmacology 6, no. 1 (2017): 38–44. http://dx.doi.org/10.31254/phyto.2017.6106.

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The leaves of Newbouldia laevis is traditionally used to treat diabetes mellitus in southeast Nigeria. The apigenin isolated from the methanol fraction of dichloromethane/methanol (1:1) extract of the leaves was evaluated for antidiabetic and antihyperglycemic activity in alloxan-induced diabetic rats and on normal rats. Treatment of alloxan-diabetic rats with the compound (apigenin) significantly (p < 0.05) reduced blood glucose, and increased the liver and muscle glycogen content. The adrenaline-induced elevation of blood glucose of normal rats was significantly (p < 0.05) reduced by t

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Famii, Zitte Leelee, Iro Chika Eke, and Agbeyi Erhomarhua Victor. "Effects of Ethanolic Extract of Vinegar Leaf (Andrographis paniculata) on Blood Sugar Level of Alloxan-Induced Diabetic Albino Rat (Rattus norvegicus)." NEWPORT INTERNATIONAL JOURNAL OF BIOLOGICAL AND APPLIED SCIENCES 6, no. 1 (2025): 40–46. https://doi.org/10.59298/nijbas/2025/6.1.404600.

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This study aimed at examining antidiabetic efficacy of ethanolic extract of vinegar leaf on blood sugar level of alloxan-induced diabetic albino rats. 25 male rats of 137-224g body weight were grouped into five groups of five animals per group. Group 1 was used as non-diabetic control, group 2, 3, 4 and 5 were induced with diabetes by administering 150mg/kg of alloxan intraperitoneally. Group 2 served as diabetic control. After 2 days of developing diabetes by group 3, 4, and 5, they were treated with vinegar ethanolic extract at concentrations of 200mg/kg, 400mg/kg, and 800mg/kg respectively.

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Zakari, A., H. Umar, and I. Auwal. "Hypoglycemic Effect of Olive Oil (Olea europea) on Alloxan- Induced Diabetic Albino Rats." Nigerian Journal of Chemical Research 28, no. 1 (2023): 051–58. http://dx.doi.org/10.4314/njcr.v28i1.5.

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This research work is aimed at investigating the hypoglycemic effect of olive oil obtained from the seeds of olive tree (Olea europea,) on alloxan-induced diabetic Albino rats. The results obtained show that olive oil (Olea europea) exhibit hypoglycemic effect on alloxan-induced diabetic Albino rats with the lower dose (150mg/kg/b.wt). as the most effective dose for the significant treatment of type 1 diabetes. Medium and High doses however showed an insignificant effect compared to the control groups. When the, standard drug (positive control) 60 mg/kg/b.wt was administered to the rats , the

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Chukwunonso Obi, Bonaventure, Theophine Chinwuba Okoye, Victor Eshu Okpashi, Christiana Nonye Igwe, and Edwin Olisah Alumanah. "Comparative Study of the Antioxidant Effects of Metformin, Glibenclamide, and Repaglinide in Alloxan-Induced Diabetic Rats." Journal of Diabetes Research 2016 (2016): 1–5. http://dx.doi.org/10.1155/2016/1635361.

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Diabetes mellitus is one of the serious global health problems affecting a significant proportion of both developed and developing countries. Overproduction of free radicals and oxidative stress has been associated with the development of diabetic complications. In the present study, the antioxidant effects of metformin (MET), glibenclamide (GLI), and repaglinide (REP) were evaluated in alloxan-induced diabetic rats. The findings from this study may possibly help in understanding the efficacy of these standard drugs in managing the complications arising from diabetes mellitus (DM). Alloxan (13

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Widjaja, Sry Suryani, and Rusdiana. "Extract Ethanol of Poguntano in Alloxan Induced Diabetic Rats." Bangladesh Journal of Medical Science 17, no. 2 (2018): 251–54. http://dx.doi.org/10.3329/bjms.v17i2.35879.

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Back Ground: Diabetes mellitus is a group of metabolic disease with high blood glucose level above 150 mg/dL over a prolonged period. The elevated of blood glucose, free fatty acid and insulin resistance will cause the endothelial dysfunction, hemostasis disturbances that lead to micro and macrovascular complications. Poguntano (Picria fel-terrae Merr) from family Scrophulariaceae found in most part of Indonesia, has been used as traditional plant for treatment of diabetes.Objective: The purpose of this study was to investigate the effect of extract ethanol of Poguntano in alloxan induced diab

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Otton, R., FG Soriano, R. Verlengia, and R. Curi. "Diabetes induces apoptosis in lymphocytes." Journal of Endocrinology 182, no. 1 (2004): 145–56. http://dx.doi.org/10.1677/joe.0.1820145.

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The occurrence of DNA fragmentation in lymphocytes obtained from alloxan-induced diabetic rats and diabetic patients was investigated. A high proportion of apoptotic lymphocytes in diabetic states may explain the impaired immune function in poorly controlled diabetic patients. Rat mesenteric lymph node lymphocytes were analysed for DNA fragmentation by using flow cytometry and agarose gel, and for chromatin condensation by Hoescht 33342 staining under different situations. Immediately after being obtained, the proportion of lymphocytes with fragmented DNA was twofold higher in alloxan-induced

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Eidangbe, George O., and Olarewaju M. Oluba. "Avocado Peel Polyphenolic-Rich Extract Attenuates Inflammatory Responses in Alloxan-Induced Diabetic Male Wistar Rats." Asian Journal of Advanced Research and Reports 18, no. 12 (2024): 436–49. https://doi.org/10.9734/ajarr/2024/v18i12841.

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Aim: This study sought to assess the effects of polyphenolic-rich extract of the peel of Persea americana (avocado) (APPE) on inflammatory responses in alloxan-induced diabetic rats. Methodology: A total of 35 alloxan-induced diabetic male rats were randomly divided into five groups (n = 7) and designated: Diabetic Control (DC), and groups receiving 25 (APPE25), 50 (APPE50), 100 (APPE100), and 200 (APPE200) mg/kg of APPE. In addition, a normal control (NC) treated with distilled water was maintained. Treatment was administered orally once daily for 21 days. Results: After 21 days, the APPE-tre

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Kebir, Nasr-Eddine, Ahmed Aichouni, and Touria Zahzeh. "Raw Camel Milk Properties on Alloxan-Induced Diabetic Wistar Rats." Romanian Journal of Diabetes Nutrition and Metabolic Diseases 24, no. 1 (2017): 41–47. http://dx.doi.org/10.1515/rjdnmd-2017-0005.

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AbstractBackground and aims: Diabetes is one of the most frequent and serious chronic diseases in humans all over the world. The aim of our study was to evaluate the antidiabetic activity of camel milk on serum glucose and lipid profile of alloxan-induced diabetic rats.Materials and methods: Diabetes was induced in Wistar albino rats by intraperitoneal injection of alloxan (120 mg/kg BW once). Albino rats each weighing 180-230g were divided into 3 equal groups (n=10) as following: G1 - normal rats fed on normal diet, G2 - diabetic rats fed on normal diet, and G3 - diabetic rats were fed with r

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OMOROWA, E. F., R. O. EDOSA, J. C. ANIONYE, et al. "EVALUATION OF THE ANTIDIABETIC AND ANTIOXIDANT EFFECT OF AQUEOUS EXTRACT OF GRAPE SEED (Vitis vinifera) ON ALLOXAN INDUCED DIABETES IN RAT." Nigerian Journal of Life Sciences (ISSN: 2276-7029) 2, no. 1 (2012): 137–43. http://dx.doi.org/10.52417/njls.v2i1.77.

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Grape seed is used traditionally for medicinal purposes for the treatment of several ailments. It is widely accepted as one of the medicinal herb with a very high antioxidant activity. However, the present study was designed to investigate the anti-diabetic activity of grape seed aqueous extract in alloxan induced diabetic rats and superoxide dismutase. Three experimental groups were compared: a control group receiving the normal diet, a diabetic control group being induced with alloxan and a treatment group receiving the aqueous extract of grape seed. Rats among the treatment group, showed a

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Chowdhury, Rifat, Mahmuda Begum, Tarak Nath Das, et al. "Efficacy and Safety of Fennel in Alloxan-induced Male Diabetic Rats." Ibrahim Cardiac Medical Journal 14, no. 1 (2025): 46–53. https://doi.org/10.3329/icmj.v14i1.80995.

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Background & objective: Diabetes mellitus is a growing global health concern characterized by chronic hyperglycemia and associated complications, including hepatotoxicity. Traditional herbal remedies like Foeniculum vulgare (fennel) have recently garnered attention for their potential therapeutic benefits. This study investigates the hepatoprotective roles of fennel in alloxan-induced male diabetic rats. Methods: An experimental study was conducted at Sir Salimullah Medical College, utilizing 30 Wistar albino male rats (90-120 days old). Following a 14-day acclimatization, the rats were di

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Sarker, Md Moklesur Rahman. "Antihyperglycemic, insulin-sensitivity and anti-hyperlipidemic potential of Ganoderma lucidum, a dietary mushroom, on alloxan- and glucocorticoid-induced diabetic Long-Evans rats." Functional Foods in Health and Disease 5, no. 12 (2015): 450. http://dx.doi.org/10.31989/ffhd.v5i12.220.

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Background: Reishi (Ganoderma lucidum) is a well-known and popular edible mushroom eaten as vegetables all over the world. It has been used as alternative medicine for long years in China, Korea, Japan, Malaysia, and in eastern Russia. It is reported to exhibit a number of medicinal properties including antitumor, antioxidant, immunomodulating, anti-inflammatory, hepatoprotective, and hypoglycemic activities due to the presence of bioactive polysaccharide. Glucocorticoids, prescribed for the treatment of arthritis to protect inflammation and reduce pain, can induce hyperglycemia or aggravate t

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Benjamin, Amadi, Ogunka-Nnoka Charity, Amadi Peter, and Ogaji Miebaka. "Nutrient composition and ameliorative effects of Cocos nucifera products on Alloxan-induced diabetic wistar rats." International Journal of Medicine 5, no. 2 (2017): 149. http://dx.doi.org/10.14419/ijm.v5i2.7647.

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Using standard methods, this study investigated the ameliorative effects of coconut products during alloxan-induced diabetic conditions. Experimental animals were divided into five groups, group 1 served as normal control rats fed only rat chow and saline, group 2 were dia-betic control rats intraperitoneally treated with 150mg/kg body weight alloxan monohydrate, group 3 were diabetic rats orally treated with 4ml/day of coconut milk, group 4 were diabetic rats orally treated with 4ml/day of coconut water, and group 5 were diabetic rats orally treat-ed with 4ml/day of a mixture of coconut milk

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Gargouri, Manel, Houda Hamed, Amel Akrouti, Xavier Dauvergne, Christian Magné, and Abdelfattah El Feki. "Effects ofSpirulina platensison lipid peroxidation, antioxidant defenses, and tissue damage in kidney of alloxan-induced diabetic rats." Applied Physiology, Nutrition, and Metabolism 43, no. 4 (2018): 345–54. http://dx.doi.org/10.1139/apnm-2017-0461.

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Chronic hyperglycemia in diabetes causes free radicals overproduction, which contributes to the development of diabetic nephropathy. In modern medicine, no satisfactory therapy is available to cure diabetes mellitus. In that context, we investigated the potential therapeutic action of spirulina-enriched diet on renal impairment and oxidative stress in diabetic rats. Diabetes was induced by a single subcutaneous injection of alloxan (120 mg·kg−1) in rats. Following alloxan treatment, male Wistar rats were fed daily with 5% spirulina-enriched diet or treated with insulin (0.5 IU·rat−1) for 3 wee

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Uroko, Robert Ikechukwu, Henry Nnaemeka Ogbonna, Chinedu Aguwamba, Paul Chukwuemeka Nweje-Anyalowu, and Benedict Chidozie Umezurike. "Assessment of Hepatoprotective and Antioxidant Effect of Acioa barteri Extract (ABE) in Alloxan-Induced Diabetic Rats." Majalah Obat Tradisional 29, no. 1 (2024): 79. http://dx.doi.org/10.22146/mot.88682.

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This study aimed to investigate the effects of Acioa barteri extract (ABE) on hepatocellular enzyme activity, hepatic function, and antioxidant stress indices in diabetic rats induced with alloxan. The antidiabetic effect of ABE was evaluated in six experimental groups: normal controls, diabetics untreated, diabetics treated with 200mg/kg, 400mg/kg, or 800 mg/kg ABE, and diabetics treated with 3 mg/kg Glibenclamide. ABE was orally administered to induce diabetes, and alloxan-monohydrate was intraperitoneally administered. Diabetic untreated rats exhibited significantly elevated levels of alkal

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Chidozie, Vivian N., Nita Mgbemena, and Emmanuel Onah Isegbe. "Comparative Effects of Ethanolic Leaf Extracts of Gongronema latifolium Benth and Bryophyllum pinnatum (Lam.) Oken in The Management of Diabetes Mellitus in Albino Rats." Afghanistan Journal of Basic Medical Science 1, no. 1 (2023): 1–10. http://dx.doi.org/10.62134/ajbms/v1.i1.khatamuni.1.

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Introduction: Diabetes is a multi-factorial metabolic disorder characterized by hyperglycemia, which is the primary factor in preventing glucose from achieving its desired levels in patients with the condition. Hyperglycemia results from a lack of insulin secretion, inadequate insulin action or both. Materials and Methods: The comparative effects of ethanolic leaf extracts of The comparative effects of ethanolic leaf extracts of Gongronema latifolium (G. latifolium) and Bryophyllum pinnatum (B. pinnatum) on some biochemical parameters in diabetic induced albino rats were investigated. Two diff

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Siriwardhene, Malitha Aravinda, Sriaandhal Sabalingam, and Anil Goonetilleke. "Antidiabetic activity of methanol extract and fractions of Costus speciosus leaves in normal and alloxan induced diabetic rats." Journal of Drug Delivery and Therapeutics 13, no. 5 (2023): 5–12. http://dx.doi.org/10.22270/jddt.v13i5.6045.

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Introduction: Costus speciosus is a common plant used for the treatment of diabetes mellitus and various other ailments in traditional medicine in Sri Lanka. The present study was conducted to investigate the hypoglycemic effect of the leaves of C. speciosus in both normal and alloxan induced male Wistar diabetic rat models. Methods: A methanolic extract of the leaves was produced and used for the preliminary phytochemicals screening. Methanol extract was further partitioned with different solvents (n-hexane, chloroform, ethyl acetate and n-butanol) according to their polarity. Male Wistar rat

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Sano, Tomoya, Kiyokazu Ozaki, Yui Terayama, Yasushi Kodama, and Tetsuro Matsuura. "A Novel Diabetic Murine Model ofCandida albicans-Induced Mucosal Inflammation and Proliferation." Journal of Diabetes Research 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/509325.

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Chronic hyperplastic candidiasis (CHC) lesions will progress to dysplasia with some of these developing squamous cell carcinoma (SCC). It is well known that diabetic patients are predisposed to candidiasis. Previously, we found that alloxan-induced diabetic rats spontaneously have mucosal hyperplasia withC. albicansinfection and that those lesions progress to SCC. Here, we developed a rat model of candidiasis with diabetes progressing to mucosal proliferation. Diabetes was induced in thirty rats by single intravenous administration of alloxan. Ten nondiabetic rats and fifteen diabetic rats the

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