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Journal articles on the topic 'Alloxan Monohydrate'

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Published: 3 June 2025
Last updated: 31 July 2025

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1

Putra, Deksa Yudha Syach, Setiyo Budi Santoso, and Heni Lutfiyati. "The Weight Performance Stability of Mice on Modeling Obesity-Associated Hyperglycemia Induced by Dextrose Monohydrate." Biology, Medicine, & Natural Product Chemistry 11, no. 2 (2022): 169–73. http://dx.doi.org/10.14421/biomedich.2022.112.169-173.

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Previously, streptozotocin and alloxan were employed to imitate hyperglycemia in mice. High doses of sucrose were also induced as an alternative. Due to body mass index has been associated with hyperglycemia, the evidence of weight body index in various induction alternate kinds, however, have not been fully reported. Here-in, we report on the weight performance stability of mice body weight induced by dextrose, streptozotocin, and alloxan. To begin, all mice were divided into six groups of five, with one reserve in each. Following seven days of acclimatization, the mice were induced for nine
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2

Kumar, Sanjeev, N. K. Prasad, and Kumari Shachi. "Therapeutic Efficacy of Ficus Glomerata Leaves in Alloxan Monohydrate Induced Type-1 Diabetes in Albino Rats." Endocrinology and Disorders 5, no. 4 (2021): 01–02. http://dx.doi.org/10.31579/2640-1045/077.

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Present study was aimed to evaluate the anti-diabetic efficacy of Ficus glomerata in Alloxan monohydrate induced albino rats. Oral administration of fresh Ficus glomerataleaves (2 - 4 g/day) for 60 days shows significant blood glucose lowering effect in experimental alloxan induced diabetic rats. These diabetic rats blood glucose level became normal when fed with Ficus glomerata leaves. It is amply revealed that fresh Ficus glomerata indica leaves possessed anti-diabetic properties. The results suggest that statistically significant anti-diabetic potential in alloxan monohydrate induced diabet
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3

Kumar, Sanjeev. "Therapeutic Potential of Aegle marmelos (Linn.) Leaves in Alloxan Monohydrate Induced Type-1 Diabetes in Experimental Rats." Diabetes & Obesity International Journal 5, no. 4 (2020): 1–6. http://dx.doi.org/10.23880/doij-16000235.

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Present study was aimed to evaluate the anti-diabetic activity of Aegle marmelos in Alloxan monohydrate induced albino rats. Oral administration of fresh Aegle marmelos leaves (2 - 4 g/day) for 28 days shows significant blood glucose lowering effect in experimental alloxan induced diabetic rats. These diabetic rats blood glucose level became normal when fed with Aegle marmelos leaves. It is amply revealed that Aegle marmelos leaves possessed anti-diabetic and beta cells restoration properties. The results suggest that statistically significant anti-diabetic potential in alloxan monohydrate ind
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4

de Oliveira, L. F. C., and P. S. Santos. "A RAMAN Spectroscopic Investigation of Alloxan and Alloxan Monohydrate." Spectroscopy Letters 24, no. 5 (1991): 749–57. http://dx.doi.org/10.1080/00387019108018155.

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5

K., Ahmed S., Chakrapani Cheekavolu, Naveen Alasyam, and Sunil M. "Evaluation of antidiabetic potential of hydroalcoholic extract of Annona squamosa (HAEAS) leaf in alloxan monohydrate induced diabetic Albino rats." International Journal of Basic & Clinical Pharmacology 7, no. 1 (2017): 179. http://dx.doi.org/10.18203/2319-2003.ijbcp20175696.

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Background: Diabetes is almost growing health concern worldwide and now emerging as an epidemic world over. Recently, full attention is being paid to the study of natural products as potential antidiabetics. Objective of the study was to evaluate the antidiabetic effect of hydroalcoholic leaf extract of Annona squamosa (HAEAS) plant in alloxan monohydrate induced diabetic albino rats.Methods: Almost a 30 Albino rats with 150- 200 grams weight were weighed and grouped into 5 equal groups taking 6 rats in every group. Group A served as normal control, Group B as diabetic control, received alloxa
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Shahid, Sammia, and Saima Taj. "Antidiabetic activity of extracts of Pistachia khinjuk on alloxan monohydrate induced diabetic mice." MATEC Web of Conferences 272 (2019): 01006. http://dx.doi.org/10.1051/matecconf/201927201006.

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Diabetes is spreading all over the world day by day. There are many ways to treat diabetes mellitus which mainly includes synthetic drugs, homeopathic medicine or Unani medicine etc. These Medicines have many side effects. Natural products; which include herbs, shrubs and large plants, cure diabetes mellitus and prove excellent hypoglycemic activity. These herbal medicines have no reported side effects. Many species of family Anacardiaceae show hypoglycemic activity and used from centuries to cure diabetes. Various pistachio species show hypoglycemic activity and have a very long history of he
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7

KAKKAR, RITA, MAMTA BHANDARI, and RITU GABA. "DFT STUDY OF SOME TRIVALENT d- AND f-BLOCK METAL ION COMPLEXES OF ALLOXAN." Journal of Theoretical and Computational Chemistry 12, no. 06 (2013): 1350052. http://dx.doi.org/10.1142/s0219633613500521.

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Density functional calculations have been employed to elucidate the structures of some six coordinated complexes of alloxan monohydrate with some d- and f-block metals. Alloxan monohydrate may exist in the mono-ionized or di-ionized form in its complexes, and both states were investigated. It is found that when the metal ion is coordinated to three bidentate ligands, the structures are nearly trigonal prismatic, but replacement of a bidendate ligand by two monovalent ligands changes the geometry to deformed octahedral. The metal-alloxanate bonding is largely ionic for the lanthanoids. The calc
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8

Lewis, Thomas C., and Derek A. Tocher. "5,5-Dihydroxybarbituric acid monohydrate (alloxan dihydrate)." Acta Crystallographica Section E Structure Reports Online 60, no. 10 (2004): o1689—o1690. http://dx.doi.org/10.1107/s1600536804021555.

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9

ABA, Patrick E., and Miracle N. EDEH. "Age Susceptibility of Wistar Rats to Alloxan-Induced Diabetes: A Paradox." Notulae Scientia Biologicae 11, no. 2 (2019): 191–95. http://dx.doi.org/10.15835/nsb11210438.

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Selection of appropriate ages of rats for experimental diabetes mellitus studies has been posing great challenges to researchers as the rats may either not come down with diabetes or may even die upon induction. This study investigated the influence of age as a possible factor affecting successful induction of diabetes mellitus in albino Wistar rats. One hundred male albino Wistar rats of varying ages weighing between 23.63 ± 0.46 g and 279.00 ± 27.00 g and assigned into ten (10) groups of ten rats per group were used for the study. Diabetes was induced in groups 1-9 consisting of rats aged 3,
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10

Yu, Tain-Jen, Ronald G. Sutherland, and Ronald E. Verrall. "The sonolysis of cytosine and thymine." Canadian Journal of Chemistry 65, no. 6 (1987): 1162–64. http://dx.doi.org/10.1139/v87-194.

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Sonolysis of cytosine has been studied at 630 kHz in the presence of air and nitrogen. The degradation products were identified by gas chromatographic – mass spectral analysis. Under aerated conditions the following products were found: urea, formyl urea, parabanic acid, isobarbituric acid, oxaluric acid, alloxan monohydrate, alloxantin, dialuric acid, and uracil glycols. Under nitrogen the degradation products were isobarbituric acid, alloxan monohydrate, and uracil glycols. The observed products have been used to develop a possible mechanism for the sonolytic degradation. There appears to be
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11

Singh, Ram, and G. Geetanjali. "Synthesis of selected novel 7-methoxycarbonyl-10-substituted isoalloxazines." Journal of the Serbian Chemical Society 71, no. 6 (2006): 575–79. http://dx.doi.org/10.2298/jsc0606575s.

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The synthesis of selected novel 7-methoxycarbonyl-10-substituted isoalloxazines by the cyclocondensation of 2-substituted aminoanilines with alloxan monohydrate under acidic condition in 21-52 % yields, is described.
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12

Harrowfield, JM, BW Skelton, AA Soudi, and AH White. "Crystal Structure of Alloxan Monohydrate: A Redetermination." Australian Journal of Chemistry 42, no. 10 (1989): 1795. http://dx.doi.org/10.1071/ch9891795.

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The structure of the title compound, C4H4N2O5, has been redetermined by single-crystal X-ray diffraction methods at c. 295 K. Crystals are triclinic, P1, a 8.217(2), b 6.809(2), c 5.765(4) �, α 66.49(3),β 81.87(3), γ 74.35(2)�, Z= 2; the structure was refined by full-matrix least squares to a residual of 0.042 for 2190 independent 'observed' reflections, typical non-hydrogen interatomic distances being determined with estimated standard deviations of 0.001 �. Together with the recent precise redetermination of the structure of alloxan , these results allow comparison of the geometries of essen
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Tài, Tạ Lâm, Trần Chí Linh, Phạm Nhi Linh та Đái Thị Xuân Trang. "ẢNH HƯỞNG CỦA CAO CHIẾT TỪ THÂN CÂY MỚP GAI (Lasia spinosa) ĐẾN HOẠT TÍNH CỦA ENZYME GLUCOSE-6-PHOSPHATASE Ở GAN VÀ THẬN CỦA CHUỘT BỊ BỆNH ĐÁI THÁO ĐƯỜNG". TNU Journal of Science and Technology 226, № 10 (2021): 47–54. http://dx.doi.org/10.34238/tnu-jst.4421.

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Nghiên cứu được thực hiện để đánh giá tác động điều hòa hoạt tính enzyme glucose-6-phosphatase trong gan và thận của cao chiết thân mớp gai trên chuột bị bệnh đái tháo đường do alloxan monohydrate. Trong nghiên cứu này, bệnh đái tháo đường ở chuột đã được gây ra bằng cách tiêm alloxan monohydrate vào trong xoang bụng chuột. Khởi phát bệnh đái tháo đường đã làm tăng hàm lượng glucose huyết và glucose-6-phosphatase một cách đáng kể (p<0,05). Cao chiết từ thân mớp gai được sử dụng ở liều 100, 200 và 400 mg/kg đối với chuột đái tháo đường do alloxan monohydrate gây ra làm giảm đáng kể (p <0,
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Ngọc, Trịnh Thị Hồng, Trần Chí Linh, Lưu Thái Quản та ін. "CÁC HOẠT ĐỘNG CHỐNG OXY HÓA, HẠ GLUCOSE HUYẾT VÀ HẠ LIPID HUYẾT CỦA CAO KHÔ VỎ BƯỞI (Citrus grandis (L.) Osbeck) Ở CHUỘT ĐÁI THÁO ĐƯỜNG BỞI ALLOXAN MONOHYDRTE". TNU Journal of Science and Technology 227, № 10 (2022): 219–27. http://dx.doi.org/10.34238/tnu-jst.6202.

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Nghiên cứu này nhằm mục đích đánh giá hoạt động chống đái tháo đường (ức chế α-glucosidase) và chống oxy hóa (trung hòa gốc tự do DPPH; tiềm năng khử sắt) in vitro của cao khô vỏ bưởi Năm Roi. Các hoạt động chống tăng glucose huyết và hạ lipid máu in vivo của cao khô vỏ bưởi Năm Roi ở chuột đái tháo đường do alloxan monohydrate gây ra đã được thực hiện. Cao khô vỏ bưởi Năm Roi có khả năng ức chế enzym α-glucosidase và chống oxy hóa. cao khô vỏ bưởi Năm Roi được sử dụng ở liều lượng thích hợp 100, 200 và 400 mg/kg cho chuột đái tháo đường do alloxan monohydrate làm giả
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15

Ibrahim Mustafa, Bushra. "Experimental diabetic nephropathy in rats injected with alloxan." Iraqi Journal of Veterinary Medicine 20, no. 1 (1996): 168–81. http://dx.doi.org/10.30539/ijvm.v20i1.1588.

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The present investigation aimed determenation of diabetic nephrepathy in alloxan treated rats. The study included: 
 
 Seruim chemical studies. 
 Histopathological and histochemical study on the kidney glomeruli. 
 
 Thirty white male rats were used. They were randomly allocated into 3 groups. Izgroup was injected with alloxan monohydrate for 30 days: 
 2nd group was fed 1% cholesterd lie and injection of 38 mg/kg B.W alloxan dialy for 30 days; 3rd group was normal diet. 
 kept on 
 Blood glucose and total Serum cholestered in 1 and 2 groups significantl
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16

Attama, SC, SC David, PF Egunleti, N. Okwelum, and TU Obetta. "Antioxidant and antidiabetic effects of aqueous extract of <i>Senna alata</i> on alloxan-induced diabetic rats." Sokoto Journal of Veterinary Sciences 21, no. 2 (2023): 65–73. http://dx.doi.org/10.4314/sokjvs.v21i2.3.

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This study aimed to evaluate the antioxidant effect and the state of the liver following injury by alloxan monohydrate and treatment with an aqueous extract of Senna alata (SA) leaf. A total of 24 male Albino Wistar rats assigned into 4 groups (A-D) of 6 rats per group were used in this study. Forty-eight hours following administration of alloxan monohydrate and confirmation of diabetes mellitus in groups B-D rats, group C were treated with SA while group D rats were treated with glibenclamide. Rats in groups A and B received distilled water. The treatments were through oral administration, on
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17

Kovpak, V. V., B. V. Borisevich, and Yu O. Kharkevych. "Microscopic changes in the liver, heart, and kidneys in alloxan diabetes rats." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 20, no. 88 (2018): 56–62. http://dx.doi.org/10.32718/nvlvet8810.

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To make future researches of the results of treatment of diabetes possible, it is necessary to create a model of this pathology in experimental animals. It is crucial to trace the correlation between changes in organs when this pathology occurs in clinical cases and when it occurs in experimental cases. Today we have a number of methods used to form alloxan diabetes in animals, but alloxan monohydrate is the most frequently used. Thus, the purpose of our study was to: study microscopic changes in the liver, heart, and kidneys of alloxan diabetes rats. The experimental model of diabetes was rep
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Hyginus, Onuigbo. "Antihypoglyceamic Effect of Some Fruits in Alloxan Induced Diabetic albino Mice." Asian Journal of Research in Biochemistry 14, no. 2 (2024): 18–22. http://dx.doi.org/10.9734/ajrb/2024/v14i2279.

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There is always paranoid by individuals suffering diabetes mellitus of any type whether to eat fruits or not, to avoid having above normal glycemic index. Glycemic index of four most and regularly consumed fruits in Nigeria were evaluated in twenty alloxan-induced diabetes mellitus healthy male albino mice matched with parity group. This was a parallel study comprising of intraperitoneally administration of single standard dose of alloxan monohydrate to test animals and equal volume of normal saline to parity matched control group. There was no disparity in glycemic index of the two study grou
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., Soni, and A. N. Mishra. "Evaluation of alloxan on induction of diabetes in albino rats." International Journal of Basic & Clinical Pharmacology 8, no. 12 (2019): 2748. http://dx.doi.org/10.18203/2319-2003.ijbcp20195290.

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Background: Alloxan-induced diabetes model is used as a “study tool” to elucidate the pathophysiology of the disease and much more as a “search engine” for antidiabetic compounds with better therapeutic characteristics. It was the first agent used in the category of chemically induced diabetes to create a model of insulin dependent diabetes mellitus. Other chemicals being streptozocin, dexamethasone, insulin antibodies-induced diabetes.Methods: Albino rats were divided into four groups with ten rats in each group. Alloxan monohydrate 2%, solution which was dissolved in 0.9% of sodium chloride
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Panwar, Shweta, Neetesh Kumar Jain, and MK Gupta. "WOUND HEALING POTENTIAL OF METHANOLIC EXTRACT OF FLOWERS OF BUTEA MONOSPERMA LINN. IN DIABETIC ANIMALS." Journal of Drug Delivery and Therapeutics 8, no. 5-s (2018): 306–10. http://dx.doi.org/10.22270/jddt.v8i5-s.1979.

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The main of our study is to evaluate the Wound Healing Potential of Methanolic Extract of Flowers of Butea monosperma Linn. in Diabetic Animals. Methanolic extract was prepared by continuous hot extraction method by soxhlet apparatus. Preliminary phytochemical screening showed the presence of flavonoids, phenolic compounds and some glycosides. Diabetes was induced by single injection of Alloxan monohydrate in Wistar albino rats and their blood glucose levels were measured. Excision wound model was used for creation of wound in diabetic animals and methanolic extract was administered in diabeti
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Fadhil, A. H. "Study of some serum biochemical changes of experimental diabetes mellitus in Donkey." Al-Qadisiyah Journal of Veterinary Medicine Sciences 12, no. 1 (2013): 15. http://dx.doi.org/10.29079/vol12iss1art224.

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This study was conducted to induce experimental diabetes in donkeys and assess some serum biochemical changes in diabetes mellitus. Fifteen donkeys were used in this experiment and divided into two groups:A. Treatment group which includes (11) donkeys. Diabetic group. denoted by Dm.B. Control group which includes (4) donkeys denoted by Cm.Animals were housed in the field. The animals were left tow weeks for adaptation. Diabetes mellitus was induced by i.v injection of alloxan monohydrate at dose rate 100 mg/kg dissolved in 25 ml of normal saline, while the control groups were injected with 25
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Makmun, Armanto, Rachmat Faisal Syamsu, Aisyah Jumadil, and Rabia. "The Potential Hypoglycemic Activities of Red Onion Extracts in Alloxan-Induced Hyperglycemic Mice." International Journal of Human and Health Sciences (IJHHS) 4, no. 2 (2020): 98. http://dx.doi.org/10.31344/ijhhs.v4i2.183.

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Objective: The present study aimed to determine the potential effect of red onion extracts on ameliorating the blood glucose levels in alloxan-induced hyperglycemic mice.Material and Methods:Hyperglicemia was induced by single intramuscular injection of 70 mg/kg body weight of alloxan monohydrate. 24 mice were randomly assigned to four groups of 6 each including alloxan control (group AC), and three alloxan groups treated with doses 25 mg/kg body weight (group AR25), 50 mg/kg body weight (group AR50), and 100 mg/ kg body weight (group AR100) of red onion extracts. The latter three groups were
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Masuda, Shota, Yoshinao Okachi, Takumi Hirao, et al. "Effect of Asperagillus awamori on Alloxan-induced Mouse Hyperglycemia." Journal of Food Research 6, no. 6 (2017): 29. http://dx.doi.org/10.5539/jfr.v6n6p29.

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Problem statement: Though alloxan-induced mouse hyperglycemia was ameliorated by feeding of 5 % Asperagillus awamori (A. awamori)-fermented burdock root diet (fermented burdock diet), it is unclear whether the anti-hyperglycemia activity is due to A. awamori or antioxidant activity induced by the fermentation.Methods: A 0.05 % A. awamori diet was prepared. Acatalasemic mice, having a quite low catalase activity in blood, were divided three groups, and each group fed control, A. awamori and the fermented burdock diets for 14 weeks, separately. Then, alloxan monohydrate (200 mg/ kg of body weigh
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Bingham, Jacob T., Brian D. Etz, Julie M. DuClos, and Shubham Vyas. "Structure and Reactivity of Alloxan Monohydrate in the Liquid Phase." Journal of Organic Chemistry 86, no. 21 (2021): 14553–62. http://dx.doi.org/10.1021/acs.joc.1c01389.

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Kim, Joo-Min, Jin-Young Chung, Sook-Yeon Lee, et al. "Hypoglycemic effects of vanadium on alloxan monohydrate induced diabetic dogs." Journal of Veterinary Science 7, no. 4 (2006): 391. http://dx.doi.org/10.4142/jvs.2006.7.4.391.

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Firmansyah, Gunawan, Hasty Martha Wijaya, Dian Arsanti Palupi, Nur Aini Karima, and Bagus Riyanto. "PENGARUH PEMBERIAN EKSTRAK ETANOL DAUN JENGKOL (Pithecellobium lobatum Benth) TERHADAP KADAR GLUKOSA DARAH PADA TIKUS PUTIH JANTAN (Rattus novergicus)." Cendekia Journal of Pharmacy 9, no. 1 (2025): 69–78. https://doi.org/10.31596/cjp.v9i1.331.

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Diabetes mellitus is a type of chronic disease with specific characteristics with blood glucose levels above normal. Jengkol leaves are one part of the plant that contains flavonoids, saponins and tannins that can be used as a treatment for DM. This study aims to understand the impact of administering ethanol extract of jengkol leaves (Phitecellobium lobatum Benth) on blood glucose levels in male white rats (Rattus novergicus). This study is an experimental study applying a pretest and posttest control group design. After checking glucose levels on H0, the rats were induced using alloxan monoh
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Rotimi, SO, I. Olayiwola, O. Ademuyiwa, and I. Adamson. "Improvement of diabetic dyslipidemia by legumes in experimental rats." African Journal of Food, Agriculture, Nutrition and Development 13, no. 57 (2013): 7606–23. http://dx.doi.org/10.18697/ajfand.57.11460.

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Grain legumes are a valuable source of food proteins; hence, their exploitation is expected to grow in relation to a growing world's food needs. Apart from high level of dietary fibre, their protein composition makes them useful in managing diabetes. This paper reports a study conducted to evaluate the effects of four different non-soy legume-based (Vigna unguiculata ssp. dekindtiana var dekindtiana, Vigna unguiculata ssp. unguiculata, Sphenostylis stenocarpa and Vigna subterranea) diets in rats administered with alloxan monohydrate (150 mg/kg bodyweight). Concentration of plasma glucose, tria
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Hilmi, Alfinda Ayurista, and Widowati Budijastuti. "Pengaruh Pemberian Senyawa Epigallocatechine gallate (EGCG) terhadap Penurunan Kadar Glukosa Darah dan Histopatologi Testis Mencit Diabetes Melitus Induksi Alloxan monohydrate." LenteraBio : Berkala Ilmiah Biologi 9, no. 2 (2021): 146–52. http://dx.doi.org/10.26740/lenterabio.v9n2.p146-152.

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Penelitian ini bertujuan untuk mendeskripsikan pengaruh pemberian senyawa Epigallocatechine gallate (EGCG) dalam menurunkan kadar glukosa darah dan histologi testis mencit induksi Alloxan monohydrate. Hewan coba yang digunakan sebanyak 24 ekor mencit jantan galur BALB/c yang dibagi menjadi 6 kelompok perlakuan, yaitu kelompok kontrol negatif (A), kontrol positif (B), Alloxan+glibenclamide (C), Alloxan+EGCG 7 mg/kgBB (D), Alloxan+EGCG 14 mg/kgBB (E) dan Alloxan+EGCG 21 mg/kgBB (F) masing-masing terdiri atas 4 ekor mencit. Pengukuran kadar glukosa darah dilakukan pada hari ke- 0, 7, 14, dan 21 s
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Farheen, Mehnoor, and Chakrapani Ramesh. "Phytochemical evaluation and pharmacological screening of ethanolic and aqueous leaf extracts of Pupalia lappacea for antihyperlipidemic and antihyperglycemic activities in alloxan induced diabetic Albino wistar rats." International Journal of Basic & Clinical Pharmacology 7, no. 4 (2018): 753. http://dx.doi.org/10.18203/2319-2003.ijbcp20181182.

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Background: Diabetes is associated with damage to the liver, pancreas and kidney. The damage may vary among patients. This study assessed the hypoglycaemic and antihyperlipidemic activities of leaves ethanolic and aqueous extracts of Pupalia lappaceae in alloxan induced diabetic albino wistar rats.Methods: There were Fifty four rats divided into nine groups containing six rats each. Group 1 consists of normal rats that were given only normal saline and served as a control group. Group 2 consists of normal rats that were given alloxan monohydrate (150mg/kg b.w). Group 3 consists alloxan induced
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Al-Assede, Ekklass H., and Kahtan A. Almzaien. "Effect Of The Aqueous Extract Of Nigella Sativa Seeds On Blood Serum Glucose, Cholesterol and Total Protein In · Alloxan-Induced Diabetic Rabbits." Iraqi Journal of Veterinary Medicine 27, no. 1 (2003): 27–40. http://dx.doi.org/10.30539/ijvm.v27i1.1094.

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The effect of five weeks oral administration of the aqueous extract of Nigella Sativa Seeds (320 mg/kg body weight) on body weight, blood glucose, cholesterol and total protein (albumin and globulin) concentrations in alloxan induced diabetic rabbits was studied. &#x0D; Twenty-four mature male rabbits were randomly assigned into three groups of eight each. Diabetes was induced experimentally by intravenous injection of alloxan monohydrate (100 mg/kg body weight) into two groups; diabetic group (D), diabetic group which was orally administrated aqueous extract of Nigella Sativa seeds (DN) while
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Wang, Jianpu, Rong Wan, Yiqun Mo, Qunwei Zhang, Leslie C. Sherwood, and Sufan Chien. "Creating a Long-Term Diabetic Rabbit Model." Experimental Diabetes Research 2010 (2010): 1–10. http://dx.doi.org/10.1155/2010/289614.

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This study was to create a long-term rabbit model of diabetes mellitus for medical studies of up to one year or longer and to evaluate the effects of chronic hyperglycemia on damage of major organs. A single dose of alloxan monohydrate (100 mg/kg) was given intravenously to 20 young New Zealand White rabbits. Another 12 age-matched normal rabbits were used as controls. Hyperglycemia developed within 48 hours after treatment with alloxan. Insulin was given daily after diabetes developed. All animals gained some body weight, but the gain was much less than the age-matched nondiabetic rabbits. Hy
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Udavant, Pavan, Gayatri Kanade, Shubham Khairnar, et al. "Preclinical Evaluation of Nerolidol’s Hepatoprotective and Nephroprotective Potential." Biomedical and Pharmacology Journal 16, no. 4 (2023): 2083–97. http://dx.doi.org/10.13005/bpj/2784.

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Background: Due to the potential negative effects of artificial food additives on health and the recent surge in consumer awareness of the issue, natural goods are becoming more and more popular in diets. Objective: The main objective of the current study is the evaluation of the protective effect and antioxidant role of Nerolidol against alloxan-induced oxidative stress, hepatotoxicity, and nephrotoxicity. Method: The present experiment was designed as Group I (control), Group II (Alloxan monohydrate, 120 mg/kg i.p), Group III (Ascorbic acid 250 mg/kg p.o), Group IV (Nerolidol 100 mg/kg p.o),
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33

Shafi, Sabeeha, and Nahida Tabassum. "PHYTOCHEMICAL SCREENING AND RENAL EFFECTS OF ETHANOLIC EXTRACT OF ERIOBOTRYA JAPONICA FRUITS AND SEEDS IN ALLOXAN INDUCED DIABETIC RATS." International Journal of Current Pharmaceutical Research 10, no. 1 (2018): 3. http://dx.doi.org/10.22159/ijcpr.2018v10i1.24399.

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Objective: The main aim of the present study was to evaluate the phytochemical constituents, and renal effects of the ethanolic extract of the fruits and seeds of Eriobotrya japonica, commonly called as Loquat in Kashmir. So far, no such study was carried in Kashmir.Methods: Phytochemical screening involved the standard procedures. Diabetes was induced in albino rats using alloxan monohydrate (120 mg/kg b. w) given i. p prepared in sterile saline. Rats were divided into 8 groups of 6 rats in each group. The ethanolic extract of Eriobotrya japonica fruits were given in doses of 50 mg/kg, 100 mg
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34

Yang, Lee Wei, Santosh Fattepur, Kiran Chanabasappa Nilugal, et al. "NEUROPROTECTION OF ABELMOSCHUS ESCULENTUS L. AGAINST DIABETIC NEUROPATHY." Asian Journal of Pharmaceutical and Clinical Research 11, no. 15 (2018): 28. http://dx.doi.org/10.22159/ajpcr.2018.v11s3.30023.

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Objective: The present study was designed to determine the neuroprotective effect of Abelmoschus esculentus L. on alloxan-induced diabetic neuropathy in rats.Methods: Diabetes was induced in rats with a single intraperitoneal injection of alloxan monohydrate (130 mg/kg b.w). The ethanol extract of A. esculentus L. at a dose of 100 and 200 mg/kg of body weight was administered at single dose per day to alloxan-induced diabetic rats for 21 days. The fasting blood glucose was screened in the intermittent on day 0, day 14, and day 21. Behavioral tests such as thermal hyperalgesia test and rotarod
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35

Chidozie, Vivian N., Nita Mgbemena, and Emmanuel Onah Isegbe. "Comparative Effects of Ethanolic Leaf Extracts of Gongronema latifolium Benth and Bryophyllum pinnatum (Lam.) Oken in The Management of Diabetes Mellitus in Albino Rats." Afghanistan Journal of Basic Medical Science 1, no. 1 (2023): 1–10. http://dx.doi.org/10.62134/ajbms/v1.i1.khatamuni.1.

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Introduction: Diabetes is a multi-factorial metabolic disorder characterized by hyperglycemia, which is the primary factor in preventing glucose from achieving its desired levels in patients with the condition. Hyperglycemia results from a lack of insulin secretion, inadequate insulin action or both. Materials and Methods: The comparative effects of ethanolic leaf extracts of The comparative effects of ethanolic leaf extracts of Gongronema latifolium (G. latifolium) and Bryophyllum pinnatum (B. pinnatum) on some biochemical parameters in diabetic induced albino rats were investigated. Two diff
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36

Onoja, Uwakwe S., Cynthia C. Ugwu, Philip F. Uzor, et al. "Effect of Anogeissus leiocarpus Guill and Perr Leaf on Hyperglycaemia and Associated Dyslipidaemia in Alloxan-induced Diabetic Rats." Dhaka University Journal of Pharmaceutical Sciences 17, no. 1 (2018): 65–72. http://dx.doi.org/10.3329/dujps.v17i1.37120.

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People living with diabetes mellitus across the world are expected to rise to 592 million by 2035 and the pandemic disease is worst in the developing countries like Nigeria, where the cost of treating/managing diabetes mellitus is relatively out of the reach of many diabetic patients. The study investigated the effect of Anogeissus leiocarpus Guill and Perr ethanolic leaf extract on blood glucose and other biochemical indices in alloxan-induced diabetic adult male Wistar albino rats. Diabetes mellitus was induced in overnight-fasted rats by a single intraperitoneal injection of alloxan monohyd
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37

Baishya, Rimashree, Anjan Adhikari, Sharmistha Biswas, and Soma Banerjee. "ANTIDIABETIC EFFECT OF MIKANIA SCANDENS ON ALLOXAN-INDUCED RAT MODEL." Asian Journal of Pharmaceutical and Clinical Research 11, no. 3 (2018): 109. http://dx.doi.org/10.22159/ajpcr.2018.v11i3.23283.

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Objective: The objective was to study the evaluation of antidiabetic and antioxidant activity of different doses ethanolic extract of Mikania scandens leaves.Methods: The rats were divided into five groups of six animals each (non-diabetic control, diabetic control, standard drug-treated, and plant treated groups (250 and 500 mg/kg body weight)). Diabetes was induced in the healthy male Wistar rats (150–200 g body weight, 4–6 weeks old) by the administration of alloxan monohydrate (150 mg/kg, i.p.). On the 0th, 3th, 7th, 11th, and 15th days, the blood samples were analyzed for blood glucose. T
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38

El Ghouizi, Asmae, Driss Ousaaid, Hassan Laaroussi, et al. "Ficus carica (Linn.) Leaf and Bud Extracts and Their Combination Attenuates Type-1 Diabetes and Its Complications via the Inhibition of Oxidative Stress." Foods 12, no. 4 (2023): 759. http://dx.doi.org/10.3390/foods12040759.

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The current work was designed to evaluate the antioxidant activity and antidiabetic effect of Ficus carica L. extracts. For that, the leaves and buds of Ficus carica L. were analyzed to determine their polyphenolic and flavonoid contents and antioxidant activity. Diabetes was induced by a single dose of alloxan monohydrate (65 mg/kg body weight), then diabetic rats were treated with a dose of 200 mg/kg body weight of the methanolic extracts of Ficus carica leaves or buds or their combination for 30 days. Throughout the experiment, blood sugar and body weight were measured every 5 and 7 days re
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Kausar, Fatima* Konde Abbulu. "ANTIDIABETIC AND ANTIHYPERLIPIDEMIC ACTIVITY OF CHONEMORPHA FRAGRANS AND ERYTHROXYLUM MONOGYNUM COMBINED ETHANOLIC LEAF EXTRACT IN ALLOXAN INDUCED DIABETIC WISTAR RATS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 01 (2017): 7428–36. https://doi.org/10.5281/zenodo.1006785.

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The objective of the present study was to evaluate the antidiabetic and antihyperlipidemic activity of herbal formulation containing Chonemorpha fragrans and Erythroxylum monogynum in alloxan induced diabetic rats. Diabetes mellitus is a group of syndrome characterized by hyperglycemia, altered metabolism of lipids, carbohydrates and proteins and an increased risk of complications from vascular diseases. Hyperlipidemia constitutes a major etiopathological factor for atherosclerosis. The preliminary phytochemical screening shows the presence of alkaloids, glycosides, carbohydrates, flavonoids,
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40

Onwubuya Ngozi, Ahur Victor M, and Bosha Joel. A. "Effect of methanol extract of cocos nucifera husk (MECH) in Alloxan-induced toxicity in Wistar male rats." World Journal of Biology Pharmacy and Health Sciences 21, no. 1 (2025): 759–67. https://doi.org/10.30574/wjbphs.2025.21.1.0099.

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The present study investigated the effect of Methanol extract of Cocos nucifera Husk (MECH) in alloxan-induced toxicity in male wistar rats. Thirty-six (36) male rats were randomly divided into six experimental groups (n=6). Group 1 was administered distilled water). Groups 2, 3, 4, 5and 6 were made diabetic by a single intraperitoneal dose of 150mg/kg body weight (bwt) of alloxon monohydrate. Group 2 served as diabetic non-treated, Group 3 (positive control) was treated orally with gibenclamide at 2mg/kg bwt. Groups 4, 5, and 6 were treated with MECH extract orally at doses of 62.5mg/kg, 125.
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Chinnappan A Kalpana and R.Abraham. "Anti- hyperglycemic activity of polyherbal formulation (Herbinsulplus) in experimental diabetes and its effects on key metabolic enzymes of carbohydrate metabolism." JOURNAL OF ADVANCED APPLIED SCIENTIFIC RESEARCH 3, no. 6 (2021): 12–20. http://dx.doi.org/10.46947/joaasr362021138.

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Diabetes mellitus is a metabolic disorder in which the body does not produce or properly utilize insulin, causes disturbances in carbohydrate, protein and lipid metabolism. In spite of the presence of series of known anti-diabetic medicine in the pharmaceutical market, remedies from medicinal plants are used with success to treat this disease. The investigation was undertaken to study the effect of polyherbal formulation on changes in Body weight, Plasma glucose, RBC, WBC, HB, Platelets, Hepatic glucokinase &amp; hexokinase, Glucose-6-phosphate and Glycogen content. In the current study, diabe
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Amarachukwu, Ikenna-Ukomadu, Ezekwe Ahamefula Sunday, Wokocha Peter Gift, and Okari Karibo Amakiri. "Effects of Anacardium Occidentale Leaf Extract on Lipid Profile and Antioxidant Levels in Diabetic Albino Rats." Asian Journal of Biochemistry, Genetics and Molecular Biology 16, no. 12 (2024): 1–13. http://dx.doi.org/10.9734/ajbgmb/2024/v16i12418.

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This study examines the lipid-lowering and antioxidant effects of aqueous leaf extract of Anacardium occidentale in alloxan-induced diabetic albino rats. Diabetes mellitus was induced in male albino rats via intraperitoneal injection of alloxan monohydrate at a dose of 120 mg/kg body weight. The diabetic rats were then treated with A. occidentale extract at a dose of 100 mg/kg body weight for 28 days. The treatment led to significant reductions in triacylglycerol, total cholesterol, and low-density lipoprotein cholesterol levels (p &lt; 0.05), while significantly increasing high-density lipopr
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Manga, Abubakar Hauwa, Ladan Mukhtar Jangebe, and Lawal Mansur. "Antidiabetic Effects of Aqueous Extracts of Bannufera Mangii Roots and Mannufera Jangii Leaves on Alloxan Induced Diabetic Rats." International Journal Of Pharmaceutical And Bio-Medical Science 02, no. 11 (2022): 534–38. http://dx.doi.org/10.47191/ijpbms/v2-i11-11.

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Diabetes is one of the leading causes of death world over, with no known scientifically proved cure so far. The present study evaluated the serum glucose lowering potentials of aqueous extracts of Bannufera mangii roots and Mannufera jangii leaves on alloxan induced diabetic rats. The most potent extract was further studied for its effects on serum insulin. Administration of 80 mg/kg of alloxan monohydrate have significantly increased blood glucose level and affect the serum insulin and lipid profile as well as oxidative stress makers. Treatments of diabetic rats with 300mg/kg body weight of t
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44

Sirajo, K. Shehu Z. Mas'ud I. &. Usman K. A. "Hepatotoxicity Assessment of Stem Bark Extract of Acacia nilotica in Alloxan Induced Diabetic Rats." Asian Journal of Research and Reports in Hepatology 4, no. 1 (2022): 59–62. https://doi.org/10.5281/zenodo.7120402.

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Aims: This research work aimed to determine the effect of methanolic Acacia nolitica stem bark extract on liver functions in alloxan induced diabetic rats. Methodology: Thirty (30) young albino rats were grouped into six (6), comprising of five (5) rats per group. Diabetes was induced by single intraperitoneal injection of freshly prepared alloxan monohydrate and blood glucose level was determined forty eight hours (48 hrs) after injection. After induction of diabetes, Metformin and selected doses of Acacia nolitica stem bark extract were orally administered for 4 weeks after which serum bioch
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45

Hamza, Muhammad, Hassan Ali Mujhtaba, Amna Aslam, Zarish Suhail, Khalid Mehmood, and Ahsan Salamat. "Hepatoprotective Role of Aqueous Extract of Kasni Seeds in Alloxan-Induced Diabetic Mice." Journal of Health and Rehabilitation Research 4, no. 3 (2024): 1–5. http://dx.doi.org/10.61919/jhrr.v4i3.1173.

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Background: Diabetes mellitus (DM) is a prevalent metabolic disorder characterized by chronic hyperglycemia, leading to various systemic complications, including liver damage. Traditional antidiabetic drugs are often associated with adverse effects, prompting interest in safer, natural alternatives like Kasni (Cichorium intybus) seeds, known for their hepatoprotective properties.Objective: This study aimed to evaluate the hepatoprotective effects of Kasni seed aqueous extract in alloxan-induced diabetic mice.Methods: Thirty-two male albino mice were divided into three groups: control, metformi
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Christian, Onahinon, Sunday Ogli, Nndunno Akwaras, Augustine Oko Adugba, and Godwin Obochi. "Impact of Nigella sativa oil on glycemic control in alloxan-induced diabetic Wistar rats." International Journal of Research in Medical Sciences 12, no. 8 (2024): 2762–66. http://dx.doi.org/10.18203/2320-6012.ijrms20242206.

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Background: To effectively manage diabetes, it is crucial to achieve optimal glycemic control by ensuring that A1C levels remain below 7.0%. This study aimed to investigate the impact of Nigella sativa oil (black seed oil, BSO) on glycemic control in alloxan-induced diabetic Wistar rats. Methods: Forty (40) male Wistar rats weighing 200-250 gm were randomly allocated into eight (8) groups of five (5) animals per group. Group 1 received normal saline as the normoglycemic control, while groups 2 to 8 were given alloxan monohydrate to induce hyperglycemia, following the method of Osikwe et al. Fo
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47

Stalin, Chandrasekeran, V. Gunasekaran, and G. Jayabalan. "Evaluation of Neuroprotective Effect of Ficus benghalensis against Alloxan Induced Diabetic Neuropathy in Rats." International Journal of Pharmacology, Phytochemistry and Ethnomedicine 4 (August 2016): 52–60. http://dx.doi.org/10.18052/www.scipress.com/ijppe.4.52.

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Neuropathic pain in diabetics is characterized by both hyperalgesia and allodynia. This is attributed to both uncontrolled glycemia and the further complications which it leads to. The objective of the study was to evaluate the neuroprotective effect of methanolic leaf extract of Ficus benghalensis against alloxan induced diabetic neuropathy in rats.Material and methods:Experimental diabetes was induced in wistar albino rats by single intraperitoneal injection of Alloxan monohydrate (150 mg/kg). The methanolic extract of leaves of Ficus benghalensis at a dose of 200 and 400 mg/kg body weight w
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48

Shahanaz Khatun and Mst. Khadiza Khatun. "Pharmacotherapeutic effect of methanolic and ethanolic extract of Spinacia oleracea L. leaves on glycemic and lipidemic indexes of alloxan-induced diabetic mice." GSC Advanced Research and Reviews 16, no. 3 (2023): 188–95. http://dx.doi.org/10.30574/gscarr.2023.16.3.0362.

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With the various side effects associated with synthetic medicines for treating diabetes, there is a need to develop herbal remedies as an alternative. Although Spinacia oleracea L. leaves are used to treat various health conditions, including diabetes, there is little research to validate its antidiabetic properties. This study aimed to investigate the hypoglycemic and hypolipidemic effect of methanolic and ethanolic extracts of Spinacia oleracea L. leaves against alloxan-induced hyperglycemia in mice. Hyperglycemia was induced by an injection of alloxan monohydrate 80mg/kg bw. (i.p.). After 7
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49

Kamran, Sairah H., Rana M. Shoaib, Mobasher Ahmad, Saiqa Ishtiaq, and Rukhsana Anwar. "Antidiabetic and renoprotective effect of Fagonia cretica L. methanolic extract and Citrus paradise Macfad. juice in alloxan induced diabetic rabbits." Journal of Pharmacy & Pharmacognosy Research 5, no. 1 (2017): 365–80. http://dx.doi.org/10.56499/jppres17.230_5.6.365.

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Context: Fagonia cretica is a medicinal herb reported to have flavanoids of potential therapeutic value and Citrus paradisi is a fruit, whose juice is of great therapeutic value due to its anti-hyperglycemic effects. Aims: To determine anti-hyperglycemic and renal protective effect of methanolic extract of Fagonia cretica and Citrus paradisi juice (grapefruit juice) in alloxan induced diabetic rabbits. Methods: Diabetes was induced in rabbits by alloxan monohydrate (150 mg/kg, i.p.). The therapies including Fagonia cretica methanolic extract (500 mg/kg), Citrus paradisi juice (7 mL/kg) and sit
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50

Elroby, Shaaban A., Saadullah G. Aziz, and Rifaat H. Hilal. "The electronic structure of alloxan monohydrate. Spectroscopic and density functional synergic approach." Journal of Molecular Structure 1130 (February 2017): 487–96. http://dx.doi.org/10.1016/j.molstruc.2016.10.069.

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