Academic literature on the topic 'Aloe saponaria'

The objective of this work was to study the chemical composition and antioxidant activity of tannins extract of Aloe saponaria (TEAS). The Aloe saponaria (syn. Aloe maculata) is a succulent plant belonging to the Xanthorrhoeaceae family, this succulent plant native to South Africa was introduced in Morocco as an ornamental plant, rustic and easy to grow. In order to ensure this, morphological and histological study method of the species, phytochemical screening, characterization of TEAS by gas chromatography coupled to mass spectrometry (GC/MS), and the study of antioxidant activity by two methods (2,2-diphenyl-1-picrylhydrazyl (DPPH) and total antioxidant capacity (TAC) assays) were examined. The results of phytochemical screening indicated that the Aloe saponaria leaf was rich of alkaloids, tannins catechics, flavonoids, sterols, triterpenes, oses, holosides, mucilages and reducing sugars. In addition, the main constituents of TEAS identified by GC/MS analysis were Linolenic acid (32.22%), Palmitic acid (17.42%), and Phytol (11.30%). Regarding antioxidant activity, the TEAS showed a significant antioxidant effect.

A chronic wound is caused by a failure to progress through the normal phases of wound repair in an orderly and timely manner. To induce skin regeneration while inhibiting chronic inflammation, numerous natural products, and in particular, plant-derived biomaterials, have been developed. Aloe saponaria, is known to contain flavonoid and phenolic acid compounds with anti-oxidative and anti-inflammatory properties. Here, we isolated extracellular vesicles (EVs) from Aloe saponaria by polyethylene glycol (PEG)-based precipitation and investigated their potential as a therapeutic for chronic wound healing. The Aloe saponaria-derived EVs (AS-EVs) showed no significant cytotoxicity on several cell types, despite a high level of intracellular uptake. When lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages were treated with AS-EVs, significant reductions in the expression of pro-inflammatory genes, such as interleukin-6 and interleukin-1β, were observed. Proliferation and migration of human dermal fibroblasts, as determined by the water-soluble tetrazolium salt-8 and transwell migration assay, respectively, were shown to be promoted by treatment with AS-EVs. It was also demonstrated that AS-EVs enhanced tube formation in human umbilical vein endothelial cells, indicating a stimulatory activity on angiogenesis; one of the crucial steps for effective wound healing. Collectively, our results suggest the potential of AS-EVs as a natural therapeutic for chronic wound healing.

Aloe vera (A. vera) has been studied as a treatment option for ulcerative colitis (UC), but there is a lack of scientific evidence showing whether treatment with Aloe saponaria (A. saponaria) can also be beneficial. To investigate the therapeutic potential of A. saponaria as a treatment for UC, clinical symptoms, histopathological characteristics of the colon, inflammatory response, and toxicity were analyzed in dextran sulfate sodium (DSS)-induced UC mice after administration of aqueous extracts of A. saponaria (AAS) for 7 days. The total polyphenol and tannin content of AAS was 272 µg/g and 163 µg/g, respectively. AAS exhibited significant antioxidant activity. Several clinical symptoms, including body weight, colon length, and hematochezia, remarkably improved in the DSS+AAS treated group compared to the DSS+Vehicle-treated group. In addition, similar improvements were detected in the histopathological characteristics and mucin-secreting ability in the colon of DSS-induced UC mice after the administration of AAS. The levels of infiltrated inflammatory cells and cytokine expression were significantly decreased in a dose-dependent manner in the colon of the DSS+AAS-treated group. These alterations in inflammatory response were accompanied by a significant recovery of the protein kinase C/extracellular signal-regulated kinase (PKC/ERK) and phosphatidylinositol-3-kinase/serine-threonine protein kinase (PI3K/Akt) signaling pathways. However, the levels of key markers for hepatotoxicity and nephrotoxicity consistently remained between those of the DSS+AAS-treated and the No groups. Therefore, the results of the present study provide novel evidence that AAS may improve the clinical symptoms and attenuate the inflammatory response in DSS-induced UC mice and does not have any significant hepatotoxicity or nephrotoxicity.

Lecto- or neotypes are designated for Aloe thompsoniae Groenew.. A. micracantha Haw .. A. schmidticma Regel (a synonym of/4, cooperi Baker). A. longistyla Baker. A. aristata Haw., A. longiaristata Schult. Schult. f„ (a synonym of the preceding name), A. humilis (L.) Mill. var. incurva Haw.. A. glauca Mill., A. niuricata Schult. (a synonym of the preceding name). A. saponaria (Aiton) Haw. var. latifolia Haw. (a new synonym of A. maculata All.) and A. pluridens Haw. The confusing citation of the type of A. thomcroftii Pole Evans is clarified.

To identify the physiological activity of Saponaria aloe cultivated in the Namhae-gun, polysaccharides, as the main physiologically active substances, were isolated and their antioxidant and anti-inflammatory activities were confirmed. Hot-air dried saponaria were extracted with hot water (80°C, 24 h) and then the extracts were freeze dried (HWE). HWE was dialyzed using 3.5 kDa dialysis membrane and only intra-dialysis solution was taken and freeze dried (IDS) for experiment. Total polysaccharide content was higher in IDS (195.32 mg/g) than HWE however, anthraquinone content was lower in IDS. Total phenolic compounds (TPC) contents of HWE and IDS were 594.04 and 1,047.23 mg/100 g, respectively. The IC50 values of 2,2-Azinobis-(3-ethylbenzo-thiazoline-6-sulphonate (ABTS) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities were higher 1.7 and 1.8 folds in HWE than IDS, respectively. The MTT assay showed that the sample concentrations below than 100 μg/mL were sufficient to exert anti-inflammatory activity in lipopolysaccharide (LPS) induced RAW 264.7 cells. The production levels of nitric oxide (NO) and reactive oxygen species (ROS) were significantly decreased in 100 μg/mL of HWE (p⟨0.01) and IDS (p⟨0.001) treated group than those in LPS only treated group. The expression levels of tumor necrosis faction (TNF)-α and interleukin (IL)-6 were significantly lower in all treated samples than in the LPS only treated group. However, there was no significant difference between the HWE and IDS-treated group. The expression activity of IL-1β was no significant difference among all samples.

Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>In Brazil, the plant Aloe saponaria Haw, popularly known as babosa pintadinha , has been empirically used for its potential effect on skin burn injury, there are no scientific data confirming its popular use. Thus, the aim of the present study was to investigate the effects of Aloe saponaria on nociceptive, inflammatory and antioxidants parameters in rat models of thermal injury. Adult male Wistar rats were subjected to a thermal injury (immersion in water at 70 or 37 ºC, respectively, for 5 or 8 seconds) or sunburn (induced by UVB irradiation), in both experiments the animals were anesthetized. Burned animals were topically treated with vehicle (base cream), sulfadiazine 1% (positive control) or Aloe saponaria cream (0.3-30%) once a day for 2 or 6 days. Each day, 30 min before the treatment, we measured nociceptive (static and dynamic mechanical allodynia, thermal allodynia and spontaneous pain), inflammatory (paw edema) parameters and oxidative stress (increases in H2O2, protein carbonyl levels and lipid peroxidation and a decrease in thiol content). In addition, was also evaluated infiltration of leukocytes in injured tissue (for histology or by measuring the activity of myeloperoxidase (MPO), N - acetyl - glucosaminidase (NAGase) and eosinoperoxidase (EPO), for neutrophils, macrophages, and eosinophils infiltration, respectively), were also determined 2 or 6 days after the thermal injury. With different efficacies time of action, the topical treatment with the Aloe saponaria cream (10%) and sulfadiazine (1%) decreased nociception, edema and leukocyte infiltration in animals induced by either thermal injury scald burn), or by UVB radiation. Moreover, the treatment with A. saponaria reduced the oxidative stress of the skin of animals irradiated with UVB, an effect that appears to be due to the antioxidant action produced by both the extract of A. saponaria, and by some of these constituents (rutin and aloin). Thus, our results demonstrate that topical application of A. saponaria showed antinociceptive, anti-inflammatory and antioxidant models of thermal injury (scald burn or solar radiation), which confirms the benefits of its traditional use for burn injuries effects.<br>Apesar da planta Aloe saponaria Haw, conhecida popularmente como "babosa pintadinha", ser utilizada na medicina popular brasileira devido ao seu efeito benéfico sobre lesões por queimaduras de pele, não existem dados científicos que confirmem o seu uso popular. Dessa forma o objetivo do presente estudo foi investigar os efeitos da A. saponaria em relação aos parâmetros nociceptivos, inflamatórios e oxidantes em modelos de lesão térmica em ratos. Para isso foram utilizados ratos Wistar machos adultos submetidos ou não à lesão térmica (causada pela imersão da pata em água a 37 ou 70 ºC durante 8 ou 5 segundos em animais anestesiados) ou queimaduras solares (induzida por radiação ultravioleta B (UVB) em animais anestesiados). Os animais foram topicamente tratados com o veículo (creme base - Lanete), sulfadiazina de 1% (controle positivo) ou com extrato de A. saponaria (0,3-30%) uma vez por dia, durante 2 ou 6 dias. Cada dia, 30 minutos antes do próximo tratamento, foram avaliados parâmetros nociceptivos (alodínia mecânica estática e dinâmica, alodínia térmica e dor espontânea), parâmetros inflamatórios (edema da pata) e estresse oxidativo (aumento dos níveis de peróxido de hidrogênio-H2O2, proteína carbonilada ou peroxidação lipídica e redução dos níveis de tióis). Além disso, em alguns tempos após os diferentes estímulos também foi avaliado a infiltração de leucócitos no tecido lesado (por análise histológica ou pela medida das atividades da mieloperoxidase - MPO, N-acetil-glucosaminidase - NAGase e eosinoperoxidase - EPO para neutrófilos, macrófagos e eosinófilos, respectivamente). Com diferentes eficácias temporais de ação, o tratamento tópico com o creme de Aloe saponaria (10%) ou de sulfadiazina (1%) reduziu a nocicepção, o edema e a infiltração de leucócitos nos animais com lesão térmica induzida tanto por água aquecida, quanto por radiação UVB. Além disso, o tratamento com A. saponaria reduziu o estresse oxidativo da pele de animais irradiada com UVB, um efeito que parece ser devido a ação antioxidante produzida tanto pelo extrato de A. saponaria, quanto por alguns de seus constituintes (aloína e rutina). Dessa forma, os nossos resultados demonstram que a aplicação tópica de A. saponaria apresentou efeitos antinociceptivos, antiinflamatórios e antioxidantes em modelos de lesão térmica (água aquecida ou radiação solar), o que confirma os benefícios do seu uso tradicional para lesões por queimaduras.

Beschrieben ist die Isolierung und Strukturaufklärung von Naturstoffen (Naphthochinone, dimere Naphthaline und Naphthylisochinolin-Alkaloide) aus Zell- und Wurzelkulturen von Triphyophyllum peltatum. Darüber hinaus wurden Experimente zur Biosynthese der Naphthylisochinolin-Alkaloide mit 13C2-markierten Vorstufen durchgeführt. Ebenso Bestandteil der Arbeit war die Etablierung von Kalluskulturen von Aloe saponaria, aus der ebenfalls Sekundärmetabolite isoliert wurden<br>The isolation and structure elucidation of natural products (naphthoquinones, dimeric naphthalenes and naphthyl isoquinoline alkaloids) from cell and root cultures of Triphyophyllum peltatum is described. Furthermore, experiments on the biosyntheses of the naphthyl isoquinoline alkaloids using 13C2 labeled precursors are reported. Additionally, callus cultures of Aloe saponaria were established and secondary metabolites were isolated