Relevant bibliographies by topics / Aloe vera

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Academic literature on the topic 'Aloe vera'

Author: Grafiati
Published: 4 June 2021
Last updated: 29 July 2024

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Journal articles on the topic "Aloe vera"

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Widyastuti, Yuni, Nia Yuliani, and I. G. A. Manik Widhyastini. "AKTIVITAS ANTIBAKTERI INFUSA DAUN LIDAH BUAYA (Aloe vera L) TERHADAP PERTUMBUHAN Staphylococcus aureus DAN Escherichia coli." JURNAL SAINS NATURAL 6, no. 1 (December 14, 2019): 33. http://dx.doi.org/10.31938/jsn.v6i1.253.

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Antibacterial Activity of Infused Aloe Vera Leaf (Aloe Vera L) on Growth Of Stapylococcus aureus and Escherichia coliDisinfectants may act as antibacterials. Aloe vera (Aloe vera L) is one of the plants that is often used by the community as a medicinal plant that has many active compounds such as lignin, saponin and anthraquinone substances that act as antibacterial. This study aims to determine the antibacterial activity of Aloe vera leaf extracted with infusa method on the growth of Staphylococcus aureus and Escherichia coli bacteria. The research method is to see the reduction / reduction of bacterial count (% reduction) after 30 second and 60 second with disc diffusion method. The results showed decrease or decrease of bacteria count (% reduction) to Escherichia coli bacteria found in aloe leaf skin infected by 28,2% after 60 seconds. While decrease or decrease of bacteria amount (% reduction) to Staphyloccocus uareus bacteria infusa mixture of meat and skin of Aloe vera leaves of 27.5% after 60 seconds. Antibacterial test of aloe vera leaf aloe (Aloe veraL) of 100% concentration by disc diffusion method did not show any inhibition zone around cultures of test bacteria.Keywords: Aloe vera, antibacterial activity, Staphylococcus aureus, and Escherichia coli, Infusa.ABSTRAKDesinfektan dapat berfungsi sebagai antibakteri. Lidah buaya (Aloe vera L) merupakan salah satu tanaman yang sering digunakan masyarakat sebagai tanaman obat yang memiliki banyak senyawa aktif seperti lignin, saponin dan antrakuinon yaitu zat yang berfungsi sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri daun lidah buaya (Aloe vera L) yang diekstrak dengan metode infusa terhadap pertumbuhan bakteri Staphylococcus aureus dan Escherichia coli. Metode penelitian yaitu dengan melihat penurunan/pengurangan jumlah bakteri (% reduksi) setelah waktu 30 detik dan 60 detik dengan metode difusi cakram. Hasil penelitian menunjukkan penurunan atau pengurangan jumlah bakteri (% reduksi) terhadap bakteri Escherichia coli terdapat pada infusa kulit daun lidah buaya yaitu sebesar 28,2 % setelah waktu 60 detik.Sedangkan penurunan atau pengurangan jumlah bakteri (% reduksi) terhadap bakteri Staphyloccocus uareus terdapat pada infusa campuran daging dan kulit daun lidah buaya yaitu sebesar 27,5 % setelah waktu 60 detik. Uji antibakteri infusa daun lidah buaya (Aloe veraL) konsentrasi 100% dengan metode difusi cakram tidak menunjukkan adanya zona penghambatan disekitar biakan bakteri uji.Kata kunci : Lidah buaya, Aktivitas antibakteri, Staphylococcus aureus, dan Escherichia coli, Infusa.
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Pegu, Arup Jyoti, and Mrs Ankita Sharma. "Review on Aloe Vera." International Journal of Trend in Scientific Research and Development Volume-3, Issue-4 (June 30, 2019): 35–40. http://dx.doi.org/10.31142/ijtsrd23541.

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Huslina, Feizia. "PENGARUH EKSTRAK DAUN LIDAH BUAYA (Aloe vera L.) TERHADAP PERTUMBUHAN JAMUR Candida albicans SECARA IN VITRO." BIOTIK: Jurnal Ilmiah Biologi Teknologi dan Kependidikan 5, no. 1 (April 1, 2017): 72. http://dx.doi.org/10.22373/biotik.v5i1.2977.

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The purpose of this study was to determine the ability of aloe vera leaf extract (Aloe vera L.) in inhibiting the growth of Candida albicans fungi through in vitro. Aloe vera (Aloe vera L.) is a plant that can overcome digestive problems caused by fungi. One of the pathogenic fungi causing gastrointestinal infections is C. albicans. This research was conducted in Microbiology Laboratory of FMIPAUnsyiah which lasted from April to May 2010. A Completely Randomized Design (RAL) consisted of 5 treatments and 5 replications is used in this study. The treatment was arranged on P0 = 20 μl distilled water, P1 = aloe vera leaf extract concentration 100%, P2 = aloe leaf extract concentration of 50% and P3 = aloe leaf extract concentration of 25%. Aloe vera leaf extract (Aloe vera L.) was given to each treatment at 20 μl. The parameter observed was the diameter of the inhibit zone formed. The data were analyzed using Variant Analysis (ANOVA), then continued with the Smallest Significant Difference (BNT) test. The results of this study indicated that the presence of aloe vera leaf extract (Aloe vera L.) could inhibit the growth of C. albicans. The higher the concentration of aloe vera leaf extract (Aloe vera L.), the higher the ability of it to inhibit C. albicans. The diameter of the inhibitory zone formed will enlarge along with the increasing of the concentration of aloe vera leaf extract (Aloe vera L.). The extract concentrations of 100%, 50% and 25% had their resistance capability of 0.50 mg, 0.24 mg and 0.20 mg of nistatin antibiotics.
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Imelda, Imelda, Jangkung Handoyo Mulyo, and Dwidjono Hadi Darwanto. "ANALISIS PERILAKU.PETANI TERHADAP RISIKO USAHATANI LIDAH BUAYA DI PONTIANAK." Agro Ekonomi 15, no. 1 (January 20, 2017): 17. http://dx.doi.org/10.22146/jae.18169.

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The research aims to: (1) identify the income differences between Aloe vera farming system with monoculture and multicultural cropping pattern; (2) identify the risk of cost, production, and income of Aloe Vera farming of each cropping pattern, (3) identify farmer behavior to the risk of each Aloe Vera farming system, and (4) determine socio-economic factors influencing the farmer behavior to the risk of Aloe Vera farming .. Research area was chosen by purposive in North 'Pontianak sub-district, West Kalimantan. Analyses used were cost and income analysis, coefficient of variation analysis, quadratic utility function, and multiple linear regressions. The results show that the Aloe Vera farmer income with monoculture cropping pattern is lower than Aloe Vera farmer with multicultural. The risk of cost, ,production, and income of Aloe Vera farming with monoculture cropping pattern is higher than multicultural. 40.74% Aloe Vera farmers with monoculture cropping pattern and 7.89% Aloe Vera farmers with multicultural show behavioral risk lover. There are 14.82% Aloe Vera farmers with monoculture cropping pattern and 28.95% Aloe Vera farmers with multicultural show behavioral risk averse. The remaining were risk neutral farmers, i.e. 44, 44% Aloe Vera farmers with monoculture cropping pattern and 63,16% Aloe Verafarmers with multicultural. Farmer behavior to the risk influenced by farmer's age, family size, farmer's experience, and dummy of cropping pattern and farmer ethnical.
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Br Siagian, Dos D. L. E., Billy J. Kepel, Aaltje Manampiring, Widdhi Bodhi, Fatimawali Fatimawali, and Fona D. H. Budiarso. "Analisis Antioksidan Senyawa Bioaktif Ekstrak Lidah Buaya Secara Insilico." Jurnal e-Biomedik 10, no. 2 (January 31, 2023): 129–35. http://dx.doi.org/10.35790/ebm.v10i2.46334.

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Abstract: Aloe vera (Aloe vera L.) is a functional plant that is often found and has a wide range of health advantages. Antioxidants are chemical molecules that inhibit free radicals in the body, which can cause disease by generating oxidation events that destroy cell structure and function. The goal of this research is to see how bioactive chemicals from the aloe vera plant (Aloe vera L.) interact with antioxidant activity. The molecular docking method is combined with insilico analysis in this study, which employs four key applications: autodock tools, autodock vina, biovia discovery studio, and open babel. All amino acid residues in the bioactive compound Aloe vera (Aloe vera L.) act on the active site of the Human endothelial nitric oxide synthase (4D1O) receptor, according to the findings of this study. The binding energi of bioactive substances from aloe vera skin extract (Aloe vera L.) to the 4D1O receptor yielded promising results. Conclusion: Aloe vera (Aloe vera L.) extract bioactive component possesses antioxidant activity, which can particularly reduce or prevent free radical generation in the body. Keywords: Aloe vera (Aloe vera L.); Antioxidant; Human endothelial nitric oxide synthase (4D1O) receptor; Insilico. Abstrak: Lidah Buaya (Aloe vera L.) merupakan tanaman fungsional yang umum ditemui dan memiliki banyak manfaat bagi kesehatan. Antioksidan adalah senyawa kimia penghambat radikal bebas di dalam tubuh yang dapat menghambat terjadinya reaksi oksidasi dalam tubuh yang dapat merusak struktur dan fungsi sel sehingga menimbulkan penyakit. Penelitian ini bertujuan untuk mengetahui interaksi antara senyawa bioaktif dari tanaman lidah buaya (Aloe vera L.) terhadap aktivitas antioksidan. Penelitian ini menggunakan metode molecular docking dengan analisis secara insilico yang menggunakan 4 aplikasi utama: autodock tools, autodock vina, biovia discovery studio, dan open babel. Hasil penelitian ini menunjukkan bahwa semua residu asam amino pada senyawa bioaktif Lidah buaya (Aloe vera L.) bekerja pada sisi aktif reseptor Human endothelial nitric oxide synthase (4D1O). Hasil binding energi senyawa bioaktif ekstrak kulit lidah buaya (Aloe vera L.) terhadap reseptor 4D1O menunjukkan nilai yang bagus. Simpulan: Senyawa bioaktif ekstrak Lidah buaya (Aloe vera L.) memiliki aktivitas antioksidan yaitu secara spesifik dapat menekan atau menghambat aktivitas pembentukan radikal bebas di dalam tubuh. Kata kunci: Lidah buaya (Aloe vera L.); Antioksidan; reseptor Human endothelial nitric oxide synthase (4D1O); Insilico.
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Isager Ahl, Louise. "Aloe Vera." Kulturstudier 13, no. 2 (November 14, 2022): 146–60. http://dx.doi.org/10.7146/ks.v13i2.134664.

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Aloe vera kendes af mange fra blomsterhandlerens potteplanter, apotekets håndkøbsprodukter eller supermarkedets sæbe- og cremesortiment. Planten er allestedsnærværende og kan beskrives som en nutidig kommerciel superstjerne. Aloe vera tilhører planteslægten Aloe, og er blot én ud af over 600 forskellige arter i denne slægt. Omkring 25% af aloerne har været brugt eller bruges i traditionel medicin i de områder, hvor de er naturligt forekommende. Slægten Aloe omtales i de tidligste medicinske skrifter, og aloerne er blevet brugt, delt, studeret og transporteret af både lægfolk og lærde folk igennem årtusinder. Det er tankevækkende, at én planteart er kommet til at dominere et kommercielt marked i en sådan grad, som Aloe vera gør i dag. De mange Aloe vera produkter på hylderne er dog et fint eksempel på et naturvidenskabeligt indhold pakket ind i en kulturhistorisk fortælling, der ligesom plantens egen historie repræsenterer en tæt sammenvævning af natur- og kulturhistorie.
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Singh, Roy Sukbir, and Hendrika A. Silitonga. "Hypolipidemic Effects Of Aloe Vera (Aloe Vera L.)." International Journal of Biomedical Herbal Medicine 1, no. 1 (December 12, 2021): 15–28. http://dx.doi.org/10.46880/ijbhm.v1i1.732.

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Background: Chronic hyperlipidemia is a trigger factor for serious diseases, one of which is atherosclerosis. Lipid profile disorders in the form of increased total cholesterol, LDL and decreased HDL levels are believed to be one of the major triggering factors for cardiovascular disease. One of the treatments for hyperlipidemia in addition to using conventional therapy can also be with traditional treatments such as aloe vera (Aloe Vera L). The content of glucomannan in aloe vera is believed to act as a hypolipidemic agent. Method: This paper uses a literature study or literature review of research articles. Search articles through Google Scholar and Pubmed with keywords used hypolipidemia and Aloe vera. The criteria for the articles used were published in the last 5 years, namely from 2016 to 2021. Results: Based on the literature search, there were 8 studies related to the effect of aloe vera on lipid profile levels, of which there were 7 studies on experimental animals and 1 study on humans. Aloe vera used varies from extract form, gel and powder form in capsules. Conclusion: Based on the literature study, it was found that aloe vera is an herbal plant that has a fairly effective hypolipidemic effect.
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Prastyaningsih, Sri Rahayu, Ambar Tri Ratnaningsih, and Dedi Zargustin. "IBM KELOMPOK TANI LIDAH BUAYA." Jurnal Ilmiah Pertanian 13, no. 2 (April 4, 2018): 81–88. http://dx.doi.org/10.31849/jip.v13i2.948.

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The cultivation of aloe vera plants began since residents in Pekanbaru know of the benefits of aloe vera plant. The group of Lidah Buaya Kita was formed in January 2014 in the District Rumbai, Pekanbaru City, Riau Province. The first time, farmers only sell seedling and leaves of aloe vera, then they make crackers and tea from leaves its own garden, where product of crackers and tea can add value to the business as one of product processed of the aloe vera plant. Partners also requested training for make drinks aloe vera. The aims of this IBM (1) make drinks aloe vera (2) techniques of processing crackers use machine flour mixer (3) Products get permits from the Dinas Kesehatan (4) analyze the nutrients and chemical of crackers and tea product (5) Make packaging of drinks, crackers and tea aloe vera (6) the promotion and marketing of aloe vera products (7) business analysis of product.IbM was implemented in 2016. Our Patners was aloe vera farmers in (1) RW 02 kelurahan Lembah Damai (2) RW 04 kelurahan Lembah Sari. The result of our IbM was (1) the partner be able to make a drink aloe vera. (2) partners have cup sealer and flour mixer machine to support their production. (3) partner has the brand, license P-IRT and test nutrient/chemical content (4) the partner is able to package the aoe vera product and ready for market (5) partners can promote aloe vera product.The cultivation of aloe vera plants began since residents in Pekanbaru know of the benefits of aloe vera plant. The group of Lidah Buaya Kita was formed in January 2014 in the District Rumbai, Pekanbaru City, Riau Province. The first time, farmers only sell seedling and leaves of aloe vera, then they make crackers and tea from leaves its own garden, where product of crackers and tea can add value to the business as one of product processed of the aloe vera plant. Partners also requested training for make drinks aloe vera. The aims of this IBM (1) make drinks aloe vera (2) techniques of processing crackers use machine flour mixer (3) Products get permits from the Dinas Kesehatan (4) analyze the nutrients and chemical of crackers and tea product (5) Make packaging of drinks, crackers and tea aloe vera (6) the promotion and marketing of aloe vera products (7) business analysis of product.IbM was implemented in 2016. Our Patners was aloe vera farmers in (1) RW 02 kelurahan Lembah Damai (2) RW 04 kelurahan Lembah Sari. The result of our IbM was (1) the partner be able to make a drink aloe vera. (2) partners have cup sealer and flour mixer machine to support their production. (3) partner has the brand, license P-IRT and test nutrient/chemical content (4) the partner is able to package the aoe vera product and ready for market (5) partners can promote aloe vera product
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Ismiyati, Ismiyati, Ratri Ariatmi Nugrahani, and Tri Yuni Hendrawati. "Diversifikasi menjadi Produk Selai dan Peningkatan Mutu Jus Aloe Vera di SIGMA Food Sawangan Depok." Jurnal Pengabdian kepada Masyarakat (Indonesian Journal of Community Engagement) 3, no. 2 (June 5, 2018): 178–83. http://dx.doi.org/10.22146/jpkm.29242.

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Community engagement activities, science and technology development for community for one of the partner SIGMA Food, Sawangan, Depok, has been done with purpose to overcome the priority problems, which are improving quality and quantity of Aloe vera juice products and diversification of Aloe vera products into jams. The abdimas team, act as the facilitator and instructor, has trained/accompanied (a) quality improvement training/counseling for Aloe vera juice by preservative addition; (b) quality improvement of Aloe vera juice in SIGMA Food by pasteurization and sterilization; and (c) diversification of Aloe vera jam product processing. The result of this training is known for improving partner’s understandings in (a) quality improvement of Aloe vera juices by preservative addition, bottle packaging sterilization process, and Aloe vera juice pasteurization; and (b) diversification of Aloe vera products.
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Widiyati, Nova Ellya, Iffah Muflihati, Rini Umiyati, and Arief Rakhman Affandi. "Pretreatment of Aloe Vera and Its Effect on the Properties of Flour and Vermicelli Produced." Jurnal Berkala Ilmiah Sains dan Terapan Kimia 17, no. 2 (October 23, 2023): 22. http://dx.doi.org/10.20527/jstk.v17i2.14900.

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Aloe vera powder has a less bright color due to the browning reaction. Pretreatment was carried out to improve the quality of aloe vera flour. Aloe vera flour can be used to manufacture food products, one of which is vermicelli. This study aimed to determine the effect of different pretreatments, namely blanching, sodium metabisulfite immersion, sodium bisulfite immersion, and steam blanching, on the characteristics of aloe vera flour and its application to vermicelli. The research steps included aloe vera pretreatment and aloe vera flour production, vermicelli production with aloe vera flour substitution, and analysis. The results showed that the pretreatment produced aloe vera and vermicelli flour with a brighter color. Pretreatment also affects water content, water-holding capacity, oil-holding capacity, and cooking properties. But the pretreatment did not affect the sensory properties of vermicelli.
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Dissertations / Theses on the topic "Aloe vera"

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Weiyang, C., A. Viljoen, J. Hammana, and z. Lu. "Intestinal Drug Transport Enhancement by Aloe vera." Planta Medica, 2009. http://encore.tut.ac.za/iii/cpro/DigitalItemViewPage.external?sp=1001728.

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Abstract The effect of Aloe vera (L.) Burm. f. (Aloe barbadensis Miller) gel and whole leaf extract on the permeability of Caco-2 cell monolayers was determined. Solutions of gel and the whole leaf extract were applied to the cell monolayers, and the transepithelial electrical resistance was monitored for 2 hours, which was then continued for another 2 hours after removal of the test solutions to measure reversibility of the effect. The transport of insulin in the presence and absence of the A. vera gel and whole leaf extract solutionswas also investigated. Both the A. vera gel and whole leaf extract were able to significantly reduce the transepithelial electrical resistance of the Caco-2 cell monolayers at concentrations above 0.5% w/ v and thereby showed the ability to open tight junctions between adjacent cells. This effect was fully reversible, as the electrical resistance of the cell monolayers returned to the original value upon removal of the test solutions. The A. vera gel and whole leaf extract solutions significantly enhanced the transport of insulin across the Caco- 2 cell monolayers compared with the control. The results suggest that these plant products have a high potential to be used as absorption enhancers in novel dosage forms for drugs with poor bioavailabilities when administered orally. On the other hand, an uncontrolled increase in the bioavailability of drugs that are taken simultaneously with A. vera gel and whole leaf extract products may result in adverse effects, and the potential exists that toxic blood plasma levels may be reached.
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Teklu, A. G. "Aloe vera: the green gold amongst us." Thesis, Сумський державний університет, 2013. http://essuir.sumdu.edu.ua/handle/123456789/31789.

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Eritrea is a country located in the arid, semi arid and mountainous parts of east Africa. During the past times, the merciless cutting and destruction of forest resources in Eritrea have resulted in environmental degradation and expansion of desertification. Land is exposed to erosion and the fertile part of the soil has been depleted. To combat this alarming situation and having realized the precarious conditions of the environment different sectors of government have been involving in various activities. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/31789
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Barreto, Gonzales Andrea Luna, Chinchay Sharon Yulissa Crispin, Gallegos Juan Carlos Mendoza, Escobar Bianca Stefanny Paredes, and Juipa Paola Lizet Ramirez. "Q’shuro: Jugo de Aloe Vera y cushuro." Bachelor's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2020. http://hdl.handle.net/10757/652643.

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El presente trabajo de investigación tiene como principal objetivo presentar al mercado de bebidas, el jugo natural elaborado a base cushuro y aloe vera. Q’shuro, es una opción de bebida alterna con altos niveles proteicos que aporta una alimentación saludable y que se encuentra dirigido a aquellas personas que tengan o deseen tendencias saludables. Es por ello, nuestra propuesta de valor es considerada como innovadora dentro del mercado de bebidas saludables puesto que incluye productos nativos del Perú y frutas oriundas para su elaboración, ofreciendo en el largo plazo un mayor portafolio de productos elaborados a base de nuestro principal insumo: cushuro. El trabajo de investigación cuenta con tres capítulos, los cuales serán presentados a continuación: Capítulo I Fundamentos Iniciales, en donde se presentará a los integrantes que conformaron el grupo académico para el desarrollo del proyecto de investigación al igual que presentar nuestra idea de negocio a los stakeholders. Capítulo II Validación del Modelo de Negocio, en esta sección se analiza los resultados obtenidos por parte de nuestros clientes potenciales en el consumo de nuestra propuesta de bebida. Asimismo, se desarrolla en base a las intenciones de compras recibidas durante las 8 semanas las proyecciones de ventas para los próximos tres años. Capítulo II Desarrollo del Plan del Negocio, en este capítulo se analiza el plan estratégico a realizar para la distribución y venta de nuestro producto al mercado objetivo, así como la programación de las actividades operacionales, recursos humanos, marketing, financiero y de responsabilidad social empresarial a utilizarse durante la realización del proyecto.
The main objective of this research work is to present to the beverage market the natural juice made from cushuro and aloe Vera. Q’shuro, is an alternative drink juice with high protein levels that provides a healthy diet and is aimed at those who have or want healthy trends. That is why our value proposition is considered as innovative within the healthy drinks market since it includes native products from Peru and native fruits for its elaboration, offering in the long term a greater portfolio of products elaborated based on our main input: cushuro. The research work has three chapters, which will be presented below: Chapter I Initial Foundations, where the members who made up the academic group for the development of the research project will be presented as well as presenting our business idea to the stakeholders. Chapter II Validation of the Business Model, this section analyzes the results obtained by our potential customers in the consumption of our beverage proposal. Likewise, sales projections for the next three years are developed based on the purchase intentions received during the 8 weeks. Chapter II Development of the Business Plan, this chapter analyzes the strategic plan to be carried out for the distribution and sale of our product to the target market, as well as the programming of operational activities, human resources, marketing, financial and corporate social responsibility to be used during the realization of the project.
Trabajo de investigación
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Hamman, JH. "Composition and Applications of Aloe vera Leaf Gel." Molecules, 2008. http://encore.tut.ac.za/iii/cpro/DigitalItemViewPage.external?sp=1000451.

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Many of the health benefits associated with Aloe vera have been attributed to the polysaccharides contained in the gel of the leaves. These biological activities include promotion of wound healing, antifungal activity, hypoglycemic or antidiabetic effects antiinflammatory, anticancer, immunomodulatory and gastroprotective properties. While the known biological activities of A. vera will be briefly discussed, it is the aim of this review to further highlight recently discovered effects and applications of the leaf gel. These effects include the potential of whole leaf or inner fillet gel liquid preparations of A. vera to enhance the intestinal absorption and bioavailability of co-administered compounds as well as enhancement of skin permeation. In addition, important pharmaceutical applications such as the use of the dried A. vera gel powder as an excipient in sustained release pharmaceutical dosage forms will be outlined.
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Morin, Emmanuel Grovel Olivier. "Aloe vera (L.) Burm.f . aspects pharmacologiques et cliniques /." [S.l.] : [s.n.], 2008. http://castore.univ-nantes.fr/castore/GetOAIRef?idDoc=47416.

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Mercês, Patrícia Lima. "AVALIAÇÃO DAS ATIVIDADES ANGIOGÊNICA E CICATRICIAL DO EXTRATO DE Aloe vera (Aloe barbadensis)." Pontifícia Universidade Católica de Goiás, 2015. http://localhost:8080/tede/handle/tede/3009.

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Objective: To evaluate the influence of Aloe vera (Aloe barbadensis) in angiogenesis and scar activity Methods: experimental study used 120 fertile eggs of chicken (Gallus domesticus) of Rhoss lineage. The eggs were incubated, and the end of the 13 °, filter paper discs, conveying 3 uL of the solution to be tested (glycolic extract of aloe vera 10%) and the proper controls were deposited directly on the Chorioallantoic Membrane-MCA so carefully to evaluate the angiogenic activity of Aloe vera. The healing activity was evaluated using 15 healthy rats of the species Rattus norvegicus albinus by creating a lesion on the dorsum of each mouse using a rectangular size 2,0x3,0cm mold, after making the injuries were applied the solution to be tested, Aloe vera and the positive and negative controls Results: regarding angiogenic activity observed If through the images that 80% of MCAs which was used Aloe vera was the formation of thicker blood vessels and in greater quantities, but there was no difference significant when compared to the positive control. Regarding scar activity results in macroscopic evaluation showed that 100% of the test group mice showed a complete closure of the lesions on the 21st day of the experiment while only 40% of the control group had complete closure. But when the Tukey test (p> 0.05), there was no statistical difference. Demonstrating how the scar activity of Aloe vera is the same as Regederm® you already have scientific evidence in wound healing. Conclusion: Aloe vera presented healing activity equal to the positive control, the MCA presented angiogenic activity equal to the positive control, with formation of new vessels, it was easy to apply and handling, conclusion themselves with what the Aloe vera extract or pro components -angiogênicos isolates may have potential pharmaceutical applications for wound treatment.
Objetivo: Avaliar a influência do Aloe vera (Aloe barbadensis) na atividade angiogênica e cicatricial Métodos: estudo experimental onde se utilizou 120 ovos férteis de galinha (Gallus domesticus) da linhagem Rhoss. Os ovos foram incubados e ao final do 13°, discos de papel de filtro, veiculando 3 µL da solução a ser testada (extrato glicólico de aloe vera a 10%), e os devidos controles, foram depositadas diretamente sobre a Membrana Corioalantóide-MCA de forma cuidadosa para avaliação da atividade angiogênica do Aloe vera. A atividade cicatricial foi avaliada utilizando 15 ratos saudáveis, da espécie Rattus norvegicus albinus, através da criação de uma lesão no dorsos de cada rato utilizando um molde do tamanho retangular 2,0x3,0cm, após a confecção da lesão eram aplicadas a solução a ser testada, Aloe vera e os controles positivo e negativo Resultados: com relação a atividade angiogênica observou se através das imagens que 80% das MCAs onde se utilizou o Aloe vera houve formação de vasos sanguíneos mais grossos e em maior quantidade, porém não apresentou diferenças significativas quando comparada ao controle positivo. Com relação a atividade cicatricial os resultados na avaliação macroscópica demonstraram que 100% dos ratos do grupo teste apresentaram um fechamento completo das lesões no 21º dia do experimento enquanto que apenas 40% do grupo controle apresentavam fechamento completo. Porém quando aplicado o teste de Tukey, (p>0,05), não houve diferença estatística. Demostrando assim que a atividade cicatricial do Aloe vera é igual à do Regederm® que já possui comprovação cientifica na cicatrização de feridas. Conclusão: o Aloe vera apresentou atividade cicatrização igual ao controle positivo, na MCA apresentou atividade angiogênica igual ao controle positivo, com formação de novos vasos, foi de fácil aplicação e manuseio, Concluindo -se com isso que o extrato de Aloe vera ou componentes pró-angiogênicos isolados podem ter potencial para aplicações farmacêuticas para o tratamento de feridas.
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Almonacid, Moscoso Antonio. "Efecto antiinflamatorio y cicatrizante del extracto liofilizado de Aloe Vera (Aloe Vera (L) burm. f.) presentado en forma de gel farmacéutico." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2012. https://hdl.handle.net/20.500.12672/2591.

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Se evaluó el efecto antiinflamatorio y cicatrizante del Gel del extracto de Aloe vera y su contenido (sábila) procedente de Lima, se preparó el Gel del extracto de Aloe vera al 20% que fue aplicado por vía tópica en 40 pacientes entre las edades 20 a 50 años, de ambos sexos, en el Establecimiento de Salud Ganimedes DISA LIMA ESTE del Ministerio de Salud, y otro grupo de 40 pacientes (grupo control) sin la aplicación del Gel del extracto de Aloe vera, comparando ambos casos se demostró la eficacia antiinflamatoria y cicatrizante del Gel del extracto de Aloe vera, que consistió en el control de la medición de la inflamación y la herida leve cerrada al paciente, desde su llegada por Emergencia (tópico) al establecimiento de Salud, por efecto de un trauma accidental o por otra índole; primero se evalúo el estado general del paciente para un diagnóstico médico, luego se plantea para su consentimiento del estudio a realizar, iniciando el uso tópico mediante controles de observación y medición de la zona inflamada y herida leve cerrada, así como el cambio de color de la piel y reacciones adversas que puede ocasionar el uso tópico hasta su recuperación total. El estudio del Gel del extracto de Aloe vera (sábila) de acuerdo con los ensayos efectuados y los objetivos generales propuestos, han demostrado su efecto anti inflamatorio y cicatrizante en la parte externa de la piel, el cual se realizó por el método mecánico y tópico. El Gel del extracto de Aloe vera, es un producto natural muy económico, de acceso fácil en su elaboración, presentando actividad antiinflamatoria y cicatrizante, administrada por vía tópica en los pacientes tratados en mención. La calidad de la inflamación y la cicatrización obtenida con Gel del extracto de Aloe vera demuestra que es de gran utilidad en tratamiento dermatológico o en cirugía plástica, obteniendo mejores resultados en regeneración de tejido o piel y epitelización de las heridas. Palabras clave:Gel del extracto de Aloe vera, efecto: antiinflamatorio y cicatrizante, Dermatológico.
The effect of anti-inflammatory and healing gel of Aloe vera and its contents (Aloe vera) from Lima, was prepared Gel Aloe vera extract 20% was applied topically to 40 patients aged 20 to 50, of both sexes, in the health facility Ganymede DISA LIMA EAST Ministry of Health, and another group of 40 patients (control group) without the application Gel of Aloe vera, comparing both anti-inflammatory efficacy was demonstrated Scar Gel and Aloe vera extract, which consisted medicine control inflammation and mild closed injury to the patient, since his arrival in Emergency (topical) the establishment of Health, due to accidental trauma or other nature, first performed an overall patient for a medical diagnosis, then posed for consent to conduct the study, starting with the topical use of observation and measurement controls the inflamed area and minor wound closed, and the change of color of the skin and can cause adverse reactions to topical total. The recovery study Gel Aloe vera (Aloe) according to those tests and the general objectives proposed have demonstrated its anti inflammatory and healing on the outside of the skin, which is performed by the mechanical method and topical. The gel of Aloe vera is a natural product very economical, easy to access in their development, presenting antiinflammatory and healing, administered topically in patients treated in mention. The inflammation and scarring gel obtained Aloe vera extract shows that it is of great use in treating dermatological or plastic surgery, obtaining better results in tissue regeneration or epithelialization of skin wounds. Key words: Gel of Aloe vera Extract, effect: anti-inflammatory and healing, Dermatology.
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Chinyemba, Patience. "Use of Aloe vera and Aloe marlothii materials as excipients in beads produced by extrusion-spheronization / Patience Chinyemba." Thesis, North-West University, 2012. http://hdl.handle.net/10394/9641.

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Microcrystalline cellulose (MCC) is the most commonly used excipient in the manufacture of spherical particles or beads by extrusion spheronisation. However, the use of MCC in beads has its limitations such as prolonged release of drugs due to lack of disintegration. The aim of this study was to determine if Aloe vera and Aloe marlothii leaf materials can be used as excipients in the production of beads prepared by extrusion spheronisation. A 23 full factorial design was employed for optimisation and to explore the effects of the concentration of MCC, polyvinylpyrrolidone and aloe materials on the sphericity and release rate of ketoprofen. Scanning electron microscopy revealed more porous beads when aloe materials were included in the bead formulations compared to the formulation with MMC alone. The bead formulations containing aloe materials exhibited faster drug release compared to that of the formulation containing MCC alone. Dissolution data of the optimised formulations were analysed in terms of mean dissolution time (MDT) as well as fit factors (f1 and f2). The optimised bead formulations had dissolution profiles comparable to that of the formulation containing MCC alone at pH 1.2 and 4.5 (f2 values > 70), but less comparable to the reference at pH 6.8 (50 < f2< 65) due to faster drug release. Aloe vera and Aloe marlothii leaf materials can be used successfully together with MCC in the production of beads by extrusion spheronisation.
Thesis (MSc (Pharmaceutics))--North-West University, Potchefstroom Campus, 2013.
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Godinho, Joanna Ferreira. "Hidrogéis de celulose bacteriana incorporados com frações de Aloe vera." reponame:Repositório Institucional da UFSC, 2014. https://repositorio.ufsc.br/xmlui/handle/123456789/129036.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia Química, Florianópolis, 2014.
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A Aloe vera, popularmente denominada babosa no Brasil, é uma planta originária da África, utilizada por culturas antigas do Mediterrâneo e do Egito devido às suas propriedades terapêuticas e medicinais. O extrato do parênquima de reserva desta planta, denominado gel de A. vera, apresenta ampla gama de compostos que possuem atividades farmacológicas de interesse medicinal. A incorporação de porções de A. vera no desenvolvimento de novos materiais, como a celulose bacteriana (CB), promove alterações morfológicas, mecânicas e químicas de grande interesse para engenharia tecidual e na produção de novas classes de dispositivos biomédicos. Na produção dos hidrogéis celulose bacteriana e A. vera, o meio de cultura da bactéria Gluconacetobacter hansenii foi formulado com três porções de A. vera, variando as concentrações de 20%, 40%, 60%, 80% a 100% (v/v). Apenas as formulações de 20%, 40% e 60% (v/v), das três porções, produziram com sucesso materiais com características distintas e singulares de microestrutura, caracterizadas por microscopia eletrônica de varredura (MEV); de propriedades mecânicas, químicas, avaliadas qualitativamente por espectroscopia de infravermelho por refletância total atenuada (FTIR-ATR); e também foram caracterizadas quanto à capacidade de absorção de água e cristalinidade. Além disso, células de fibroblastos da linhagem L929, foram semeadas sobre os materiais para avaliação da citotoxicidade, adesão e morfologia celular em função do tempo. Os fibroblastos permaneceram viáveis em até 48 horas de cultura em todos os hidrogéis desenvolvidos e apresentaram morfologia alongada e melhor aderência nas membranas formuladas com 60% das três porções. Os materiais formulados com 60% de A. vera na celulose bacteriana se mostraram plataformas promissoras para o desenvolvimento de dispositivos para regeneração de pele.

Abstract : Aloe vera, usually known in Brazil as "babosa", originary plant from Africa, was used by ancient cultures of the Mediterranean and Egypt due to therapeutic and medicinal properties. The parenchyma reserve extract of this plant, called A. vera gel, presents a wide range of compounds which has pharmacological activities of medicinal interests. The incorporation of A. vera portions in development of new materials, such as bacterial cellulose (BC), promotes morphological, chemical and mechanical changes of great interests for tissue engineering and production of new classes of biomedical devices. In the production of bacteria cellulose and A. vera hydrogels, the culture medium of the bacteria Gluconacetobacter hansenii was formulated with three portions A. vera, raging the concentrations from 20%, 40 %, 60 %, 80% to 100% (v/v). Only formulations of 20 % , 40 % and 60 % (v/v), for three portions, produced successfully materials with distinct and unique characteristics of microstructure; characterized by scanning electron microscopy (SEM); mechanical and chemical properties; evaluated qualitatively by infrared spectroscopy by attenuated total reflectance (FTIR-ATR), and were also characterized by their ability to absorb water and crystallinity. Moreover, fibroblast cells of the L929 strain were seeded on the material to evaluate cytotoxicity, cell adhesion and morphology as a function of time. Fibroblasts remained viable for up to 48 hours of culture, in all developed hydrogels, and showed elongated morphology and better adhesion on the membranes formulated with 60 % of the three portions. The materials formulated with 60% of A. vera into bacterial cellulose proved are promising scaffold for the development of new devices for skin regeneration.
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Keyhanian, Shirin. "Phytochemisches Screening der Blüten von Aloe vera (L.) Burm. f. (Aloe barbadensis Mill.) und Bestimmung ihrer antioxidativen Kapazität." Aachen Shaker, 2008. http://d-nb.info/990121151/04.

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Books on the topic "Aloe vera"

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Barn, O. Tinya: Aloe vera. Orlu, Imo state [Nigeria]: Samoke Nature Cure Link, 2002.

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Davidson, Frena Gray. Miracle plants: Aloe vera. London: Century Pub., 1985.

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Atherton, Peter. The essential Aloe Vera. Thornborough Mill: Mill Enterprises, 1996.

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Gloria, Richard, ed. An aloe vera cookbook. Sacramento, CA: Matney Media's, 2008.

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Bloomfield, Frena. Miracle plants, aloe vera. London: Century Publishing Co., 1985.

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Davis, Robert H. Aloe vera: A scientific approach. New York: Vantage Press, 1997.

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Neumyvakin, I. P. Aloė: Mify i realʹnostʹ. Moskva: Dili︠a︡, 2008.

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Hornsey-Pennell, Paul. Aloe Vera: The natural healer. Bordon: Wordsmith Publishing Company Ltd, 1996.

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Ritter, Lee. Aloe vera: A mission discovered. Northglenn, Colo: L. Ritter, 1993.

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Skousen, Max B. Sábila: Aloe vera, salud, belleza y vitalidad. México, D.F: Editora y Distribuidora Yug, 1993.

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Book chapters on the topic "Aloe vera"

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Ross, Ivan A. "Aloe vera." In Medicinal Plants of the World, 103–31. Totowa, NJ: Humana Press, 2003. http://dx.doi.org/10.1007/978-1-59259-365-1_4.

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Dev, Sukh. "Aloe vera." In Prime Ayurvedic Plant Drugs, 83–91. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-22075-3_8.

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Christophe, Wiart. "Indian Aloe (Aloe vera L.)." In Handbook of Medicinal Plants of the World for Aging, 25–27. Boca Raton: CRC Press, 2023. http://dx.doi.org/10.1201/9781003301455-10.

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Sen, Surjit, Shuvadip Mondal, Arghya Naskar, Protha Biswas, Tuyelee Das, Rupa Sanyal, Abhijit Dey, and Manjula Rai. "Aloe vera (L.) Burm.f." In Antidiabetic Medicinal Plants and Herbal Treatments, 75–93. Boca Raton: CRC Press, 2023. http://dx.doi.org/10.1201/b23347-5.

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Mosleh, Ghazaleh, and Abdolali Mohagheghzadeh. "Aloe vera (L.) Burm.f." In Therapeutic Medicinal Plants in Traditional Persian Medicine, 13–21. Boca Raton: CRC Press, 2024. http://dx.doi.org/10.1201/b22971-3.

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Gong, Muxin, and Xuran Lu. "Aloe barbadensis Miller 芦荟 (Luhui, Aloe vera)." In Dietary Chinese Herbs, 577–85. Vienna: Springer Vienna, 2015. http://dx.doi.org/10.1007/978-3-211-99448-1_66.

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Bussmann, Rainer W., Narel Y. Paniagua-Zambrana, and Grace N. Njoroge. "Aloe sp. Aloe vera (L.) Burm. f. Asphodelaceae." In Ethnobotany of the Mountain Regions of Africa, 1–5. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-319-77086-4_13-1.

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Bussmann, Rainer W., Narel Y. Paniagua-Zambrana, and Grace N. Njoroge. "Aloe sp. Aloe vera (L.) Burm. f. Asphodelaceae." In Ethnobotany of the Mountain Regions of Africa, 147–51. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-38386-2_13.

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Vandebroek, Ina, and David Picking. "Aloe vera (L.) Burm.f. (Asphodelaceae)." In Advances in Economic Botany, 13–26. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-48927-4_2.

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Kharchoufa, Loubna, and Rainer W. Bussmann. "Aloe vera (L.) Burm. f.Asphodelaceae." In Ethnobotany of Mountain Regions, 1–6. Cham: Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-031-13933-8_23-1.

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Conference papers on the topic "Aloe vera"

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Sari, Ressy, Bakti Waluyo, Farhan Harahap, Divo Sitompul, Md Taufiq, and Sapriyanto Saragih. "Smart Watering System for Aloe Vera." In Proceedings of the 4th Annual Conference of Engineering and Implementation on Vocational Education, ACEIVE 2022, 20 October 2022, Medan, North Sumatra, Indonesia. EAI, 2023. http://dx.doi.org/10.4108/eai.20-10-2022.2329061.

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Kuponiyi, Abiola, Lamin Kassama, and Tatiana Kukhtareva. "Physicochemical characterization of silver nanoparticles synthesize using Aloe Vera (Aloe barbadensis)." In SPIE NanoScience + Engineering, edited by Norihisa Kobayashi, Fahima Ouchen, and Ileana Rau. SPIE, 2014. http://dx.doi.org/10.1117/12.2062170.

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Hidayat. "Yield Stability of Some Aloe Vera Clone." In International Conference on Natural Resources and Sustainable Development. SCITEPRESS - Science and Technology Publications, 2018. http://dx.doi.org/10.5220/0009899800002480.

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Miao, Mingsan, Lin Guo, Yalei Yang, Bolin Cheng, and Pengran Han. "Topical anti-inflammatory effects of Aloe Vera juice." In International conference on Human Health and Medical Engineering. Southampton, UK: WIT Press, 2014. http://dx.doi.org/10.2495/hhme130631.

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Dewi, Sinta Ratna, Sylvan Septian Ressandy, Lidya Handoko, and Jati Pratiwi. "Antibacterial activites emulgel citronella oil (Cymbopogon nardus (L) Rendle) and extract aloe vera (Aloe vera. (L) Brum.F.) against staphylococcus epidermidis." In IWOSP 2021, INTERNATIONAL WORKSHOP ON STATISTICAL PHYSICS. AIP Publishing, 2023. http://dx.doi.org/10.1063/5.0123770.

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Tuong Phuoc Tho and Nguyen Truong Thinh. "A study of Aloe vera peeling and dicing system." In 2017 International Conference on System Science and Engineering (ICSSE). IEEE, 2017. http://dx.doi.org/10.1109/icsse.2017.8030834.

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Edis, Zehra, Samir Haj Bloukh, and Hamed Abu Sara. "Antimicrobial properties of PVP-encapsulated Aloe vera -iodine hybrids." In 6th International Electronic Conference on Medicinal Chemistry. Basel, Switzerland: MDPI, 2020. http://dx.doi.org/10.3390/ecmc2020-07275.

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Baracskai, Zlatko, Marija Sumarac, and Nicoletta Saulig. "Unconventional Audio Signal Processing: Aloe Vera Summing and Panning." In 2020 5th International Conference on Smart and Sustainable Technologies (SpliTech). IEEE, 2020. http://dx.doi.org/10.23919/splitech49282.2020.9243693.

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Sugianti, Nuraliyah. "Effect of Aloe Vera Drink on Intensity of Dysmenorrhea in Students, Tangerang, Banten." In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.05.37.

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ABSTRACT Background: WHO reported that more than 50% of women suffered dysmenorrhea in each nation. Concerning to side effects of analgetic drugs, harmless herbal therapeutic need to be considered as alternative medicine. Besides wide use of Aloe vera as cosmetics, it was also reported as a potent analgesic. This study aimed to investigate the effect of aloe vera drink on the intensity of dysmenorrhea in students at the School of Health Sciences Yatsi, Tangerang. Subjects and Method: A quasi-experiment with one group pretest-posttest without a control group was conducted at School of Health Sciences Yatsi, Tangerang from February to March. A total of 30 female students aged 18-21 years was selected by incidental sampling, in which 5 study subjects’ unmet criteria inclusion were dropped out. The criteria inclusion were female students, unmarried, during pre-menstruation period, no recently pain reliever used, and consent to consume aloe vera drink regularly for six days. The dependent variable was the intensity of dysmenorrhea. The intensity of dysmenorrhea was measured by McGill Pain questionnaires conducted two times at three days before and day 3 of menstruation. The independent variable was aloe vera drink consumption. The data were analyzed by paired t-test. Results: The intensity of dysmenorrhea in study subjects was reduced after treatment with aloe vera drink (Mean= 1.56; SD= 0.71) than before treatment (Mean= 2.68; SD= 0.75), and it was statistically significant (p <0.001). Conclusion: Aloe vera drinks consumption reduce the intensity of dysmenorrhea. Keywords: aloe vera drink, dysmenorrhea, intensity, female adolescents Correspondence: Solihati. Nursing Program Study, School of Health Sciences Yatsi, Tangerang. Email: solyan8000@gmail.com. Mobile: 085691903637. DOI: https://doi.org/10.26911/the7thicph.05.37
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Caleb I Nindo, Joseph R Powers, and Juming Tang. "Glass Transition and Rheological Properties of Aloe Vera (Aloe Barbadensis, L.) Dried by Different Methods." In 2007 Minneapolis, Minnesota, June 17-20, 2007. St. Joseph, MI: American Society of Agricultural and Biological Engineers, 2007. http://dx.doi.org/10.13031/2013.23326.

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Reports on the topic "Aloe vera"

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Zuluaga Mogollón, María Victoria, Yury Yessenia Beltrán, and Angélica María Ramírez Beltrán. Cadena de sábila Aloe vera L.: anexo 5. Corporación Colombiana de Investigación Agropecuaria - AGROSAVIA, 2017. http://dx.doi.org/10.21930/agrosavia.fichasocioeconomica.2017.1.

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Este capítulo da a conocer información básica sobre la sábila, su producción, consumo, vínculos con la ciencia, la tecnología y la innovación y las demandas del sector sobre conocimiento técnico, a fin de dar solución a los problemas productivos, mejorar la sostenibilidad y aprovechar oportunidades de mercado, generando así, alternativas para la consolidación de sistemas territoriales de innovación.
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Chopra, Swamini, Kavita Pande, and Abhay Deshmukh. Aloe vera based electrolytic solution for environment friendly batteries. Peeref, March 2023. http://dx.doi.org/10.54985/peeref.2303p6019960.

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Lin, Yun-Kuan, Yu-Ning Huang, Kun-Chuan Chen, and Jen-Hung Wang. Effects of Aloe vera on burns: a systematic review and meta-analysis of randomized controlled trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, October 2023. http://dx.doi.org/10.37766/inplasy2023.10.0018.

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Flórez Martínez, Diego Hernando. Estudio de inteligencia competitiva para la cadena productiva de la sábila. Corporación Colombiana de Investigación Agropecuaria - AGROSAVIA, 2014. http://dx.doi.org/10.21930/agrosavia.vigilanciatecnologica.2014.2.

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Este documento se construye como un estudio exploratorio para el fortalecimiento de la cadena productiva de la sábila en Colombia, contemplando aspectos de la variable comercial y la variable tecnológica que permitan fortalecer los procesos de formulación, ejecución y evaluación de la agenda de investigación, establecer lineamientos estratégicos y conocer la dinámica del entorno frente a este producto del sector agropecuario/agroindustrial. La sábila o aloe vera, es una planta de hojas suculentas elongadas y espinosas en el margen, se encuentra en regiones tropicales y subtropicales, también se pueden encontrar en regiones desérticas y semidesérticas
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Galbraith, Mel, and Dan Blanchon. Biology is not Alone: The Interdisciplinary Nature of Biosecurity. Unitec ePress, September 2015. http://dx.doi.org/10.34074/pibs.rs12015.

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Recognition and management of anthropogenic environmental impacts as ‘biosecurity’ is a relatively new concept to our society. Although biosecurity risks are based on biological impacts, biosecurity management is truly interdisciplinary-transdisciplinary since the definition and interpretation of risk and adverse effects are socially constructed, and the outcomes and management of the risks can have significant social and economic impacts. The New Zealand biosecurity strategy is very clear that the responsibilities for environmental risk management lie with society as a whole. The authors explore how disciplines other than biology may contribute to the understanding of biosecurity risks, their management and mitigation. This paper outlines the interdisciplinary-transdisciplinary nature of biosecurity, with an emphasis on the social and economic elements.
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F, Verdugo-Paiva, Acuña María Paz, Solá Iván, and Rada Gabriel. Is remdesivir an effective intervention in people with acute COVID-19? Epistemonikos Interactive Evidence Synthesis, October 2023. http://dx.doi.org/10.30846/ies.527e413d283.v1.

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Objective Provide a timely, rigorous and continuously updated summary of the evidence on the role of remdesivir in the treatment of patients with COVID-19. Methods Eligible studies were randomized trials evaluating the effect of remdesivir versus placebo or no treatment. We conducted searches in the special L·OVE (Living OVerview of Evidence) platform for COVID-19, a system that performs regular searches in databases, trial registries, preprint servers and websites relevant to COVID-19. All the searches covered the period until 25 August 2020. No date or language restrictions were applied. Two reviewers independently evaluated potentially eligible studies according to predefined selection criteria, and extracted data on study characteristics, methods, outcomes, and risk of bias, using a predesigned, standardized form. We performed meta-analyses using random-effect models and assessed overall certainty in evidence using the GRADE approach. A living, web-based version of this review will be openly available during the COVID-19 pandemic. Results Our search strategy yielded 574 references. Finally, we included three randomized trials evaluating remdesivir in addition to standard care versus standard care alone. The evidence is very uncertain about the effect of remdesivir on mortality (RR 0.7, 95% CI 0.46 to 1.05; very low certainty evidence) and the need for invasive mechanical ventilation (RR 0.69, 95% CI 0.39 to 1.24; very low certainty evidence). On the other hand, remdesivir likely results in a large increase in the incidence of adverse effects in patients with COVID-19 (RR 1.29, 95% CI 0.58 to 2.84; moderate certainty evidence). Conclusions The evidence is insufficient for the outcomes critical for making decisions on the role of remdesivir in the treatment of patients with COVID-19, so it is impossible to balance potential benefits, if there are any, with the adverse effects and costs. PROSPERO Registration number: CRD42020183384.
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F, Verdugo-Paiva, Acuña M, Solá I, and Rada G. Is remdesivir an effective intervention in people with acute COVID-19? Epistemonikos Interactive Evidence Synthesis, September 2023. http://dx.doi.org/10.30846/ies.527e413d28.v2.

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Objective The aim of this living systematic review is to provide a summary of the effects of placebo or no treatment in the fullname of remdesivir. Methods Eligible studies were randomized trials evaluating the effect of remdesivir versus placebo or no treatment. We conducted searches in the special L·OVE (Living OVerview of Evidence) platform for COVID-19, a system that performs regular searches in databases, trial registries, preprint servers and websites relevant to COVID-19. All the searches covered the period until 25 August 2020. No date or language restrictions were applied. Two reviewers independently evaluated potentially eligible studies according to predefined selection criteria, and extracted data on study characteristics, methods, outcomes, and risk of bias, using a predesigned, standardized form. We performed meta-analyses using random-effect models and assessed overall certainty in evidence using the GRADE approach. A living, web-based version of this review will be openly available during the COVID-19 pandemic. Results Our search strategy yielded 574 references. Finally, we included three randomized trials evaluating remdesivir in addition to standard care versus standard care alone. The evidence is very uncertain about the effect of remdesivir on mortality (RR 0.7, 95% CI 0.46 to 1.05; very low certainty evidence) and the need for invasive mechanical ventilation (RR 0.69, 95% CI 0.39 to 1.24; very low certainty evidence). On the other hand, remdesivir likely results in a large increase in the incidence of adverse effects in patients with COVID-19 (RR 1.29, 95% CI 0.58 to 2.84; moderate certainty evidence). Conclusions The evidence is insufficient for the outcomes critical for making decisions on the role of remdesivir in the treatment of patients with COVID-19. PROSPERO Registration number: CRD42020183384.
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F, Verdugo-Paiva, Acuña M, Solá I, and Rada G. In patients with acute COVID-19, should remdesivir be used compared to placebo? (First Version). Epistemonikos Interactive Evidence Synthesis, September 2023. http://dx.doi.org/10.30846/ies.81be92ee95.

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Abstract:
Objective The aim of this living systematic review is to provide a summary of the effects of remdesivir in the treatment of patients with acute covid-19. Methods Eligible studies were randomized trials evaluating the effect of remdesivir versus placebo or no treatment. We conducted searches in the special L·OVE (Living OVerview of Evidence) platform for COVID-19, a system that performs regular searches in databases, trial registries, preprint servers and websites relevant to COVID-19. All the searches covered the period until 25 August 2020. No date or language restrictions were applied. Two reviewers independently evaluated potentially eligible studies according to predefined selection criteria, and extracted data on study characteristics, methods, outcomes, and risk of bias, using a predesigned, standardized form. We performed meta-analyses using random-effect models and assessed overall certainty in evidence using the GRADE approach. A living, web-based version of this review will be openly available during the COVID-19 pandemic. Results Our search strategy yielded 574 references. Finally, we included three randomized trials evaluating remdesivir in addition to standard care versus standard care alone. The evidence is very uncertain about the effect of remdesivir on mortality (RR 0.7, 95% CI 0.46 to 1.05; very low certainty evidence) and the need for invasive mechanical ventilation (RR 0.69, 95% CI 0.39 to 1.24; very low certainty evidence). On the other hand, remdesivir likely results in a large increase in the incidence of adverse effects in patients with COVID-19 (RR 1.29, 95% CI 0.58 to 2.84; moderate certainty evidence). Conclusions The evidence is insufficient for the outcomes critical for making decisions on the role of remdesivir in the treatment of patients with COVID-19. PROSPERO Registration number: CRD42020183384.
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F, Verdugo-Paiva, Acuña M, Solá I, and Rada G. In patients with acute COVID-19, should remdesivir be used compared to placebo? (First Version). Epistemonikos Interactive Evidence Synthesis, September 2023. http://dx.doi.org/10.30846/ies.81be92ee95.v1.

Full text
Abstract:
Objective The aim of this living systematic review is to provide a summary of the effects of remdesivir in the treatment of patients with acute covid-19. Methods Eligible studies were randomized trials evaluating the effect of remdesivir versus placebo or no treatment. We conducted searches in the special L·OVE (Living OVerview of Evidence) platform for COVID-19, a system that performs regular searches in databases, trial registries, preprint servers and websites relevant to COVID-19. All the searches covered the period until 25 August 2020. No date or language restrictions were applied. Two reviewers independently evaluated potentially eligible studies according to predefined selection criteria, and extracted data on study characteristics, methods, outcomes, and risk of bias, using a predesigned, standardized form. We performed meta-analyses using random-effect models and assessed overall certainty in evidence using the GRADE approach. A living, web-based version of this review will be openly available during the COVID-19 pandemic. Results Our search strategy yielded 574 references. Finally, we included three randomized trials evaluating remdesivir in addition to standard care versus standard care alone. The evidence is very uncertain about the effect of remdesivir on mortality (RR 0.7, 95% CI 0.46 to 1.05; very low certainty evidence) and the need for invasive mechanical ventilation (RR 0.69, 95% CI 0.39 to 1.24; very low certainty evidence). On the other hand, remdesivir likely results in a large increase in the incidence of adverse effects in patients with COVID-19 (RR 1.29, 95% CI 0.58 to 2.84; moderate certainty evidence). Conclusions The evidence is insufficient for the outcomes critical for making decisions on the role of remdesivir in the treatment of patients with COVID-19. PROSPERO Registration number: CRD42020183384.
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Moxham-Hall, Vivienne, Anton du Toit, and Deshanie Rawlings. Clinical interventions for e-cigarette cessation in young people: an Evidence Snapshot brokered by the Sax Institute for the NSW Ministry of Health. The Sax Institute, December 2022. http://dx.doi.org/10.57022/fyfv7482.

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Key messages • We found that there are limited studies analysing the effectiveness of e-cigarette cessation interventions in a clinical setting and of those that do exist the sample sizes are small, and the studies are underpowered to make any confident assessment of their effectiveness. • Clinical interventions appropriate for young people included nonpharmacologic interventions such as contingency management and behavioural counselling while NRT may be an effective pharmacologic intervention. • There was limited evidence to demonstrate the effectiveness of behavioural counselling as a stand-alone cessation strategy, but it may be effective in conjunction with other approaches. • Emerging evidence suggests that digital cessation interventions (i.e. text message or app-based delivery) may be the preferred mode of delivery for young people, however, their effectiveness in maintaining abstinence is yet to be confirmed. • Evidence suggests there is a need to quantify and create a consistent measure of nicotine intake to appropriately inform clinical treatment decisions. • Studies are generally very low quality, and it is not possible nor is it appropriate to make any definitive conclusions.
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