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Journal articles on the topic 'ALP'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Kelati, Awatef, Asmae Rasso, and Soumiya Chiheb. "Dermoscopy of Actinic Lichen Planus in Skin of Color." Dermatology Practical & Conceptual 14, no. 2 (2024): e2024101. http://dx.doi.org/10.5826/dpc.1402a101.

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Introduction: Actinic Lichen Planus (ALP) is a rare photosensitive variant of lichen planus. Four subtypes can be distinguished: pigmented, annular (AALP), plaque-like and dyschromic ALP. Methods: This is a retrospective; descriptive and analytical study investigating the dermoscopic patterns of different subtypes of ALP in skin of color. Results: Sixteen adult patients were included in this study; the majority of them were young females; while five patients with the pigmented subtype of ALP were more than 50 years old. This subtype was more prevalent in patients with phototype IV. AALP was de

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Jaiswal, Preetee, Pradeep Kumar, V. K. Singh, and D. K. Singh. "Enzyme Inhibition by Molluscicidal Components of Myristica fragrans Houtt. in the Nervous Tissue of Snail Lymnaea acuminata." Enzyme Research 2010 (December 6, 2010): 1–6. http://dx.doi.org/10.4061/2010/478746.

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This study was designed to investigate the effects of molluscicidal components of Myristica fragrans Houtt. (Myristicaceae) on certain enzymes in the nervous tissue of freshwater snail Lymnaea acuminata Lamarck (Lymnaeidae). In vivo and in vitro treatments of trimyristin and myristicin (active molluscicidal components of Myristica fragrans Houtt.) significantly inhibited the acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of Lymnaea acuminata. The inhibition kinetics of these enzymes indicates that both the trimyristin and myristicin caused

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Adeyemi, OS, and MA Akanji. "Biochemical changes in the kidney and liver of rats following administration of ethanolic extract of Psidium guajava leaves." Human & Experimental Toxicology 30, no. 9 (2010): 1266–74. http://dx.doi.org/10.1177/0960327110388534.

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Furtherance to a previous report on the anti-trypanosomal properties of Psidium guajava aqueous leaf extract in rats experimentally infected with Trypanosoma brucei brucei, we have evaluated the effects of the daily intraperitoneal administration of P. guajava leaf extract to rats on the activities of alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and acid phosphatase (ACP) in the kidney, liver and serum. The results obtained revealed that the administration of the extract produced significant increase in the serum activities of AST, ALT, ALP and A

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Zheng, Mengli, Yan Bai, Yingxia Sun, Jing An, Qinghua Chen, and Tieying Zhang. "Effects of Different Proteases on Protein Digestion In Vitro and In Vivo and Growth Performance of Broilers Fed Corn–Soybean Meal Diets." Animals 13, no. 11 (2023): 1746. http://dx.doi.org/10.3390/ani13111746.

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This study was conducted to investigate the effects of different proteases alone or in combination on protein digestibility of broilers. In vitro, the properties of four proteases in broilers, including acidic protease (AcP), alkaline protease (AlP), neutral protease (NeP) and keratinase (Ker), on endogenous protease activity and their effects on protein digestibility of common ingredients in broiler diets were investigated using a gut-mimicking model. In vivo, 640 1-day-old male broilers were randomly divided into 8 groups of 10 with 8 replicates of 10 birds per replicate cage. Eight dietary

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Zhao, Han, Xinfa Liu, and Changbei Ma. "Sensitive Fluorescence Assay for the Detection of Alkaline Phosphatase Based on a Cu2+-Thiamine System." Sensors 21, no. 3 (2021): 674. http://dx.doi.org/10.3390/s21030674.

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The authors describe a novel, facile, and sensitive fluorometric strategy based on a Cu2+-thiamine (Cu2+-TH) system for the detection of alkaline phosphatase (ALP) activity and inhibition. The principle of the method is as follows. Under a basic conditions, TH, which does not exhibit a fluorescence signal, is oxidized into fluorescent thiochrome (TC) by Cu2+. Ascorbic acid 2-phosphate (AAP), which is the enzyme substrate, is hydrolyzed to produce ascorbic acid (AA) by ALP. The newly formed AA then reduces Cu2+ to Cu+, which prevents the oxidation of TH by Cu2+; as a result, the fluorescent sig

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6

Calagari, Kiana, Mohammad Reza Pakravan, Shervin Shirmohammadi, and Mohamed Hefeeda. "ALP." ACM Transactions on Multimedia Computing, Communications, and Applications 11, no. 2 (2015): 1–23. http://dx.doi.org/10.1145/2656203.

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Sasanka, Ruchira, Man-Lap Li, Sarita V. Adve, Yen-Kuang Chen, and Eric Debes. "ALP." ACM Transactions on Architecture and Code Optimization 4, no. 1 (2007): 3. http://dx.doi.org/10.1145/1216544.1216546.

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8

Boonmars, T., Z. Wu, I. Nagano, T. Nakada, and Y. Takahashi. "Differences and similarities of nurse cells in cysts of Trichinella spiralis and T. pseudospiralis." Journal of Helminthology 78, no. 1 (2004): 7–16. http://dx.doi.org/10.1079/joh2003203.

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AbstractThe nurse cell in the cyst of Trichinella spiralis comprises at least two kinds of cytoplasm, derived from muscle or satellite cells, as indicated by the pattern of staining using regular dye (haematoxylin and eosin, or toluidine blue), alkaline phosphatase (ALP) expression, acid phosphatase (ACP) expression and immunostaining with an anti-intermediate filament protein (desmin or keratin). Muscle cells undergo basophilic changes following a T. spiralis infection and transform to the nurse cells, accompanied by an increase in ACP activity and the disappearance of desmin. Satellite cells

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Kapoor, Priyanka, Nitika Monga, Om Prakash Kharbanda, Sunil Kapila, Ragini Miglani, and Rajeswari Moganty. "Effect of orthodontic forces on levels of enzymes in gingival crevicular fluid (GCF): A systematic review." Dental Press Journal of Orthodontics 24, no. 2 (2019): 40.e1–40.e22. http://dx.doi.org/10.1590/2177-6709.24.2.40.e1-22.onl.

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Abstract Objective: Orthodontic force application releases multiple enzymes in gingival crevicular fluid (GCF) for activation, resorption, reversal, deposition of osseous elements and extracellular matrix degradation. The current systematic review critically evaluated all existing evidence on enzymes in orthodontic tooth movement. Methods: Literature was searched with predetermined search strategy on electronic databases (PubMed, Scopus, Embase), along with hand search. Results: Initial search identified 652 studies, shortlisted to 52 studies based on PRISMA. Quality assessment further led to

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Xia, Feng, Elijah Ndhlovu, Zhicheng Liu, Xiaoping Chen, Bixiang Zhang, and Peng Zhu. "Alpha-Fetoprotein+Alkaline Phosphatase (A-A) Score Can Predict the Prognosis of Patients with Ruptured Hepatocellular Carcinoma Underwent Hepatectomy." Disease Markers 2022 (April 21, 2022): 1–16. http://dx.doi.org/10.1155/2022/9934189.

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Background. This research is aimed at establishing a scoring system alpha-fetoprotein+alkaline phosphatase (A-A score) based on preoperative serum alpha-fetoprotein (AFP) and alkaline phosphatase (ALP) levels and to investigate its clinical significance in patients with ruptured hepatocellular carcinoma (rHCC) after hepatectomy. Methods. 175 ruptured hepatocellular carcinoma (HCC) patients treated with hepatectomy were included. Survival analysis was assessed by the Kaplan-Meier method. Prognostic factors were analyzed in a multivariate model. Preoperative serum AFP and ALP values are assigned

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Atanaska, Teneva, Stoimenov Georgi, Hristov Kalin, Koynarski Tsvetoslav, and Stoimenov Alexandar. "ANALYSIS OF BLOOD BIOCHEMICAL PROFILES OF DAIRY COWS AND THEIR CALVES FROM BULGARIAN BROWN CATTLE BREED." TRADITION AND MODERNITY IN VETERINARY MEDICINE 6, no. 2 (2021): 78–83. https://doi.org/10.5281/zenodo.5741612.

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Present study was conducted to analyze the blood biochemical parameters of a total 271 Bulgarian Brown Cattle Breed and their calves. We evaluated the activities of aspartate aminotransferase (ASAT), alanine ami-notrans-ferase (ALAT), alkaline phosphatase (ALP), acid phosphatase (ACP), albumin (Alb), total protein (TP), creatin-phosphokinase (CPK), total lipid (TL), calcium (Ca), ceruloplasmin (CP) in their serum. The cows was 2–12 years old, mean body weight 600 kg and the calves 1–9 months old. The cows were held in an intensive farm breeding premises. Their meal consisted of ord

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Xue, Yijiong, Chengqi Bao, Hui Liu, Fanghui Ma, Minghui Yang, and Xiaoqing Li. "BSA-Assisted Synthesis of Au Nanoclusters/MnO2 Nanosheets for Fluorescence “Switch-On” Detection of Alkaline Phosphatase." Biosensors 15, no. 1 (2025): 49. https://doi.org/10.3390/bios15010049.

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A fluorescence probe for “switch-on” detection of alkaline phosphatase (ALP) was developed based on Au nanoclusters anchored MnO2 nanosheets (Au NCs-MnO2 NSs), which were synthesized using bovine serum albumin (BSA) as template through a simple one-pot approach. In the sensing system, MnO2 NSs function as both energy acceptors and target identifiers, effectively quenches the fluorescence of Au NCs via fluorescence resonance energy transfer (FRET). The presence of ALP catalyzes the hydrolysis of L-ascorbic acid-2-phosphate (AAP) to ascorbic acid (AA), reducing MnO2 NSs to Mn2+ and facilitate th

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13

Berner, Robert L., and Christopher Hope. "Kruger's Alp." World Literature Today 60, no. 1 (1986): 167. http://dx.doi.org/10.2307/40141392.

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14

Chadha-Day, Francesca, James Maxwell, and Jessica Turner. "ALP anarchy." Journal of Cosmology and Astroparticle Physics 2024, no. 09 (2024): 056. http://dx.doi.org/10.1088/1475-7516/2024/09/056.

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Abstract String theory models generically predict the existence of multiple axion-like particle (ALP) fields, yet the majority of both theoretical and experimental works have assumed only one ALP. In this paper, we discuss the phenomenology of systems with multiple ALPs that can undergo oscillations akin to neutrino oscillations. Motivated by this effect, we extend the `anarchy' framework, which has been used to predict neutrino oscillation parameters, to generate the parameters of many ALP systems. We explore the phenomenology of these ALP anarchy models in some of the leading ALP search stra

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15

Coleman, Tara, and Jacqueline Jones. "Rebooting ALP." Journal of Basic Writing 43, no. 2 (2024): 79–94. https://doi.org/10.37514/jbw-j.2024.43.2.05.

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16

Chen, Sheng-Yi, Jui-Hung Shien, and Hong Kean Ooi. "Serum Alpha-fetoprotein in Rabbits Experimentally Infected with Rabbit Haemorrhagic Disease Virus." Acta Veterinaria Brno 78, no. 3 (2009): 477–81. http://dx.doi.org/10.2754/avb200978030477.

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To investigate the change in serum alpha-fetoprotein (AFP) and its correlation with liver enzymes in hepatitis caused by rabbit haemorrhagic disease virus (RHDV), 15-week-old rabbits were experimentally infected with a Taiwan field isolate of the virus. After RHDV inoculation, it was observed that serum AFP increased significantly (p = 0.0082) together with significant elevation in serum aspartate amino transferase (AST), alanine amino transferase (ALT), γ-glutamyl transferase (γ-GT) and alkaline phosphatase (ALP). Rabbits that died tended to have high AFP values prior to death, the mean value

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17

Baeeri, Maryam, Marjan Shariatpanahi, Amir Baghaei, et al. "On the benefit of magnetic magnesium nanocarrier in cardiovascular toxicity of aluminum phosphide." Toxicology and Industrial Health 29, no. 2 (2011): 126–35. http://dx.doi.org/10.1177/0748233711425074.

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The present study was designed to determine the effect of a new 25Mg2+-carrying nanoparticle (25MgPMC16) on energy depletion, oxidative stress, and electrocardiographic (ECG) parameters on heart tissue of the rats poisoned by aluminum phosphide (AlP). 25MgPMC16 at doses of 0.025, 0.05, and 0.1 median lethal dose (LD50 = 896 mg/kg) was administered intravenously (iv) 30 min after a single intragastric administration of AlP (0.25 LD50). Sodium bicarbonate (Bicarb; 2 mEq/kg, iv) was used as the standard therapy. After anesthesia, the animals were rapidly connected to an electronic cardiovascular

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18

Miura, Masakazu, Yoshikatsu Sakagishi, Keishi Hata, and Tsugikazu Komoda. "Differences between the Sugar Moieties of Liver- and Bone-Type Alkaline Phosphatases: A Re-Evaluation." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 31, no. 1 (1994): 25–30. http://dx.doi.org/10.1177/000456329403100104.

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We re-evaluated the differences between the sugar moieties of liver and bone alkaline phosphatases (ALPs). Sialic acid was added to ALP sugar moieties by α2,3- or 2,6-sialyltransferase treatment of the asialo-form ALP (neuraminidase-treated ALP). Asialo-bone ALP was converted to a liver-like ALP by the 2,6-sialyltransferase treatment. The resulting liver-like ALP was less susceptible to neuraminidase than non-treated bone ALP, but was still labile to heat exposure at 56°C like non-treated bone ALP. However, after the O-linked sugar moiety had been released by additional treatment with O-glycan

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K. K, Kalpana Devi, and Prakash Sahaya leon J. "Toxic Effect Of Cypermethrin On Enzymes In Freshwater Fish Oreochromis Mossambicus (Tilapia)." International Journal of pharma and Bio Sciences 11, no. 6 (2021): 137–43. http://dx.doi.org/10.22376/ijpbs/lpr.2021.11.6.l137-143.

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In agriculture, excessive use of various pesticides had increased in developing countries. These pesticides may be highly toxic, not only to aquatic organisms like fishes but also to humans. In recent years, synthetic pyrethroids were developed for major uses in various agriculture practices and public health purposes. We aim to find the toxic Effect of Cypermethrin on Freshwater Fish Oreochromis mossambicus (Tilapia). The fish Oreochromis mossambicus were exposed for 30 days to various sub lethal concentrations (1/10, 1/20, and 1/30) of cypermethrin. After completion of a 30 days exposure, th

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20

Avdeev, O., R. Drevnitska, N. Gevkaliuk, Yu Bandrivsky, and A. Boykiv. "Changes in the activity of phosphatases, calcium and phosphorus in rats with the different courses of gingivitis under correction by anti-inflammatory gel." Ukrainian Biochemical Journal 94, no. 5 (2022): 59–68. http://dx.doi.org/10.15407/ubj94.05.059.

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The aim of the study was to evaluate changes in the activity of acid and alkaline phosphatases, calcium and phosphorus levels in rats with different courses of experimental gingivitis upon treatment with anti-inflammatory gel with Neovitin and peptide complexes. The experiment was conducted on 100 white nonlinear male rats aged 5-6 months divided into 10 groups: 1 control and 9 – with different courseі of gingivitis. The activity of alkaline and acid phosphatase (ALP, ACP), the levels of calcium (Ca) and phosphorus (P) in rat blood serum and gingiva supernatant were determined. It was found th

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Abo, Isaac Kanu, Nancy Amara Mbachu, Mark Matthew Edet, Ifeoma Priscillia Ezeugwunne, and Nneka Mabel Ugwu. "EVALUATION OF SOME LIVER ENZYMES AND ALPHA-FETOPROTEIN IN WORKERS OCCUPATIONALLY EXPOSED TO E-WASTE IN NNEWI, ANAMBRA STATE NIGERIA." Journal of Advanced Research in Medical and Health Science (ISSN 2208-2425) 10, no. 4 (2024): 57–61. http://dx.doi.org/10.61841/x7j5n426.

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BACKGROUND: The advent of electricity has spurred significant technological advancements, leading to the production of numerous electrical and electronic devices. This progress, however, has resulted in a surge of largely irreparable electronic waste (e-waste) being constantly shipped to Nnewi, a metropolitan city with large-scale commercial and industrialactivities. E-waste contains thousands of chemicals, many of which are toxic to humans upon exposure.AIM OF THE STUDY: To evaluate the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP),

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Hu, Xuemei, Chaoqun Sun, Ying Shi, Yijuan Long та Huzhi Zheng. "Colorimetric sensing of alkaline phosphatase and α-fetoprotein based on the photoinduced oxidase activity of fluorescein". New Journal of Chemistry 43, № 11 (2019): 4525–30. http://dx.doi.org/10.1039/c8nj06427j.

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23

Chicco, Davide, and Luca Oneto. "Computational intelligence identifies alkaline phosphatase (ALP), alpha-fetoprotein (AFP), and hemoglobin levels as most predictive survival factors for hepatocellular carcinoma." Health Informatics Journal 27, no. 1 (2021): 146045822098420. http://dx.doi.org/10.1177/1460458220984205.

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Liver cancer kills approximately 800 thousand people annually worldwide, and its most common subtype is hepatocellular carcinoma (HCC), which usually affects people with cirrhosis. Predicting survival of patients with HCC remains an important challenge, especially because technologies needed for this scope are not available in all hospitals. In this context, machine learning applied to medical records can be a fast, low-cost tool to predict survival and detect the most predictive features from health records. In this study, we analyzed medical data of 165 patients with HCC: we employed computa

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Llorente-Pelayo, Sandra, Pablo Docio, Bernardo A. Lavín-Gómez, et al. "Modified Serum ALP Values and Timing of Apparition of Knee Epiphyseal Ossification Centers in Preterm Infants with Cholestasis and Risk of Concomitant Metabolic Bone Disease of Prematurity." Nutrients 12, no. 12 (2020): 3854. http://dx.doi.org/10.3390/nu12123854.

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The usefulness of serum alkaline phosphatase (ALP) and phosphorous in screening and monitoring of metabolic bone disease of prematurity (MBDP) still has some limitations, especially in preterm infants with concomitant conditions such as cholestasis. We aimed to assess a modification of serum ALP (M-ALP) as a biomarker for MBDP in preterm infants, and the use of ultrasound monitoring for the apparition of knee ossification centers as marker of bone mineralization. Biochemical and clinical registers were taken from 94 preterm newborns <32 weeks. A significant correlation existed between serum

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Farley, J. R., S. L. Hall, S. Herring, C. Libanati, and J. E. Wergedal. "Reference standards for quantification of skeletal alkaline phosphatase activity in serum by heat inactivation and lectin precipitation." Clinical Chemistry 39, no. 9 (1993): 1878–84. http://dx.doi.org/10.1093/clinchem/39.9.1878.

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Abstract Putative standards of skeletal alkaline phosphatase (ALP) (from bone, bone cells, osteosarcoma cells, and Pagetic serum) and hepatic ALP (from cholestatic serum and bile) were used to compare three methods for quantifying skeletal ALP activity in serum: heat inactivation, precipitation with wheat germ agglutinin (WGA), and precipitation with concanavalin A (Con A). All the skeletal ALP standards were similarly sensitive to heat inactivation, as were the hepatic ALP standards. Heat inactivation separated skeletal from hepatic ALP by a 50% difference in remaining ALP activities (e.g., 2

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Feng, Gaoke, Chaoshi Qin, Fei Sha, Yongnan Lyu, Jinggang Xia, and Xuejun Jiang. "Evaluation of Inflammatory and Calcification after Implantation of Bioabsorbable Poly-L-Lactic Acid/Amorphous Calcium Phosphate Scaffolds in Porcine Coronary Arteries." Journal of Nanomaterials 2021 (January 23, 2021): 1–8. http://dx.doi.org/10.1155/2021/6652648.

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Purpose. Our previous research has confirmed that the addition of nano-amorphous calcium phosphate (ACP) materials can improve the support of poly-L-lactic acid (PLLA) vascular scaffolds. Based on this, we continued to explore the effect of novel bioresorbable scaffold composed of PLLA and ACP nanoparticles on inflammation and calcification of surrounding tissues after scaffold implantation in porcine coronary artery. Methods. PLLA/ACP scaffolds in the experimental group and PLLA scaffolds in the control group were implanted into the coronary arteries of small pigs. Serum levels of C-reactive

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Han, Hsiao-Fen, and Mary C. Beckerle. "The ALP-Enigma Protein ALP-1 Functions in Actin Filament Organization to Promote Muscle Structural Integrity in Caenorhabditis elegans." Molecular Biology of the Cell 20, no. 9 (2009): 2361–70. http://dx.doi.org/10.1091/mbc.e08-06-0584.

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Mutations that affect the Z-disk–associated ALP-Enigma proteins have been linked to human muscular and cardiac diseases. Despite their clear physiological significance for human health, the mechanism of action of ALP-Enigma proteins is largely unknown. In Caenorhabditis elegans, the ALP-Enigma protein family is encoded by a single gene, alp-1; thus C. elegans provides an excellent model to study ALP-Enigma function. Here we present a molecular and genetic analysis of ALP-Enigma function in C. elegans. We show that ALP-1 and α-actinin colocalize at dense bodies where actin filaments are anchore

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Aldayel, Tahany Saleh, Mohamed M. Badran, Abdullah H. Alomrani, et al. "Chitosan-Coated Solid Lipid Nanoparticles as an Efficient Avenue for Boosted Biological Activities of Aloe perryi: Antioxidant, Antibacterial, and Anticancer Potential." Molecules 28, no. 8 (2023): 3569. http://dx.doi.org/10.3390/molecules28083569.

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Aloe perryi (ALP) is an herb that has several biological activities such as antioxidant, antibacterial, and antitumor effects and is frequently used to treat a wide range of illnesses. The activity of many compounds is augmented by loading them in nanocarriers. In this study, ALP-loaded nanosystems were developed to improve their biological activity. Among different nanocarriers, solid lipid nanoparticles (ALP-SLNs), chitosan nanoparticles (ALP-CSNPs), and CS-coated SLNs (C-ALP-SLNs) were explored. The particle size, polydispersity index (PDI), zeta potential, encapsulation efficiency, and rel

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Farley, J. R., E. Kyeyune-Nyombi, N. M. Tarbaux, S. L. Hall, and D. D. Strong. "Alkaline phosphatase activity from human osteosarcoma cell line SaOS-2: an isoenzyme standard for quantifying skeletal alkaline phosphatase activity in serum." Clinical Chemistry 35, no. 2 (1989): 223–29. http://dx.doi.org/10.1093/clinchem/35.2.223.

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Abstract Earlier we described a kinetic assay for quantifying skeletal alkaline phosphatase (ALP) isoenzyme activity in serum. The precision of the assay depends on including ALP standards for the skeletal, hepatic, intestinal, and placental isoenzymes. We wondered whether human osteosarcoma cells could provide an efficient alternative to human bone or Pagetic serum as a source of the skeletal ALP standard. ALP activities prepared from five human osteosarcoma cell lines were compared with a bone-derived ALP standard with respect to heat stability and sensitivity to chemical effectors. Two of t

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Nurmala, Nurmala, Fetri Lestari, and Ratu Choesrina. "POTENSI EKSTRAK BUAH KECIPIR (Psophocarpus tetragonolobus (L.) DC.) SEBAGAI ANTIOSTEOPOROSIS DENGAN PARAMETER PENINGKATAN ALKALIN FOSFATASE PADA TIKUS WISTAR BETINA YANG DIINDUKSI DEKSAMETASON." Jurnal Ilmiah Farmasi Farmasyifa 1, no. 1 (2017): 18–25. http://dx.doi.org/10.29313/jiff.v1i1.3082.

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Kecipir (Psophocarpus tetragonolobus (L.) DC.) merupakan tanaman polong-polongan (Fabaceae) yang mengandung fitoestrogen, berperan dalam mencegah kehilangan massa tulang akibat defisiensi estrogen. Penelitian ini bertujuan untuk mengetahui aktivitas ekstrak etanol buah kecipir sebagai antiosteoporosis berdasarkan kadar ALP (Alkaline phosphatase) plasma pada tikus yang diinduksi deksametason. Tikus dikelompokkan menjadi tiga kelompok yaitu kontrol positif, kontrol negatif dan kelompok uji (ekstrak dosis 500 mg/kg BB). Kelompok kontrol positif dan kelompok uji diberi induksi deksametason 0,1 mg/

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Van Hoof, V. O., M. Martin, P. Blockx, et al. "Immunoradiometric method and electrophoretic system compared for quantifying bone alkaline phosphatase in serum." Clinical Chemistry 41, no. 6 (1995): 853–57. http://dx.doi.org/10.1093/clinchem/41.6.853.

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Abstract Agarose electrophoresis (Isopal, Beckman) and an immunoradiometric assay (IRMA) involving specific monoclonal antibodies (Ostase, Hybritech), two methods for the quantification of serum bone alkaline phosphatase (ALP, EC 3.1.3.1), a marker of osteoblastic activity, were compared in 293 patients: 79 with end-stage renal failure treated with hemodialysis and 214 with malignant disease. Overall correlation between the two methods was good (r = 0.92), except (a) for low values of bone ALP and (b) in some samples with high total liver ALP activity--both due to considerable cross-reactivity

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Broyles, Dennis L., Randall G. Nielsen, Elizabeth M. Bussett, et al. "Analytical and clinical performance characteristics of Tandem-MP Ostase, a new immunoassay for serum bone alkaline phosphatase." Clinical Chemistry 44, no. 10 (1998): 2139–47. http://dx.doi.org/10.1093/clinchem/44.10.2139.

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Abstract The performance characteristics of the Tandem®-MP Ostase® assay, a new microplate immunoassay for bone-specific alkaline phosphatase (bone ALP; EC 3.1.3.1) in human sera, are described. Bone ALP is bound to streptavidin-coated microwells by a single biotinylated anti-bone ALP monoclonal antibody. Antigen is detected by the addition of p-nitrophenyl phosphate. The assay is performed at room temperature in &lt;90 min. Imprecision was 2.3–6.1% with a detection limit of 0.6 μg/L. Method comparison of bone ALP measurements with the Tandem-MP Ostase assay and the mass-based Tandem-R Ost

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Van Hoof, V. O., A. T. Van Oosterom, L. G. Lepoutre, and M. E. De Broe. "Alkaline Phosphatase Isoenzyme Patterns in Malignant Disease." Clinical Chemistry 38, no. 12 (1992): 2546–51. http://dx.doi.org/10.1093/clinchem/38.12.2546.

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Abstract Early treatment of patients with malignant disease and liver or bone metastasis may increase their survival time. We have used the activity patterns of liver and bone isoenzymes of alkaline phosphatase (ALP), separated by agarose gel electrophoresis, to detect early metastasis. We studied ALP isoenzyme patterns in a background population of 101 patients with no evidence of any disease that might influence this pattern; a healthy reference population (n = 330); and the following three groups of patients: 143 with malignant disease, 47 with nonmalignant liver disease, and 22 with nonmal

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Van Hoof, V. O., L. G. Lepoutre, M. F. Hoylaerts, R. Chevigné, and M. E. De Broe. "Improved agarose electrophoretic method for separating alkaline phosphatase isoenzymes in serum." Clinical Chemistry 34, no. 9 (1988): 1857–62. http://dx.doi.org/10.1093/clinchem/34.9.1853.

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Abstract A modified agarose electrophoretic system for the separation of alkaline phosphatase (ALP, EC 3.1.3.1) isoenzymes is described. Bone, liver, high-molecular-mass, and intestinal ALP are separated with high reproducibility. The sensitivity of the agarose system is superior to cellulose acetate in detecting high-Mr ALP. Correlation is good between bone ALP fractions scanned before and after treatment with neuraminidase. Immunoglobulin-bound ALPs, the ALP-lipoprotein-X complex, and the additional ALP fraction observed in transient hyperphosphatasemia in children are detected by their pecu

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Griffiths, W. C., P. D. Camara, M. Rosner, R. Lev, and E. M. Brooks. "Prevalence and Properties of the Intestinal Alkaline Phosphatase Identified in Serum by Cellulose Acetate Electrophoresis." Clinical Chemistry 38, no. 4 (1992): 507–11. http://dx.doi.org/10.1093/clinchem/38.4.507.

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Abstract We investigated the prevalence and characteristics of intestinal alkaline phosphatase (ALP; EC 3.1.3.1) identified in human serum by cellulose acetate electrophoresis in 8% of fasting serum samples from hospital patients (n = 500) and in 35% of fasting serum samples from patients with diabetes mellitus (n = 106; not differentiated between types 1 and 2). The intestinal ALP electrophoretic band was usually heterogeneous and contained two major subtypes of ALP. Isoelectric focusing of intestinal-ALP-positive serum treated with levamisole and neuraminidase (EC 3.2.1.18) revealed two dist

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Ramasamy, I. "Persistent Increase in Serum Alkaline Phosphatase in a Patient with Monoclonal Gammopathy of Undefined Significance." Case Reports in Hematology 2020 (January 31, 2020): 1–5. http://dx.doi.org/10.1155/2020/8406971.

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We report the finding of alkaline phosphatase-immunoglobulin complex (macro-alkaline phosphatase (macro-ALP)) in a patient with persistently increased ALP activity. The identification of macro-ALP is important to rule out pathological causes of increased ALP activity and to avoid unnecessary diagnostic investigation. The patient was subsequently diagnosed with vitamin D deficiency, gallstone pancreatitis, and monoclonal gammopathy of undefined significance (MGUS). Macro-ALP can coexist with disease that can increase serum ALP activity. We report, for the first time, a case of macro-ALP in a pa

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Zeki, İzzetullah. "ALP TEGİNÎDS Reign." Hikmet Dernegi 3, no. 1 (2022): 61–78. http://dx.doi.org/10.48117/diwan.2022.17.

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KONUKÇU, ENVER. "KONUR ALP İLİ." Türkiyat Mecmuası 24, no. 1 (2014): 15. http://dx.doi.org/10.18345/tm.05196.

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Singha, Dhrubajyoti, Md Fahad Jubayer, Kumkum Devnath, et al. "Nutritional, Textural, and Sensory Quality of Aloe Vera Leaf Gel Powder Fortified Plain Cake." J 4, no. 3 (2021): 430–43. http://dx.doi.org/10.3390/j4030033.

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Aloe Vera leaves have great potential as an economic supplement with an adequate nutritional profile. The current study aimed to fortify plain (loaf) cakes with Aloe Vera leaf gel (AVG) powder. AVG was freeze-dried to produce Aloe Vera powder (ALP), and four plain (loaf) cakes were prepared with different proportions of ALP (0, 4, 6, and 8%). ALP contained significantly (p < 0.05) more protein (22.23 vs. 12.24), ash (19.83 vs. 0.64), and iron (175 vs. 3.05) than refined wheat flour (RWF). Along with total polyphenols and total flavonoids, ALP demonstrated good antioxidant activity. ALP-cake

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Xie, Guifang, Fujing Mao, Yirui Huang, et al. "Enzyme Cascade Amplification-Based Immunoassay Using Alkaline Phosphatase-Linked Single-Chain Variable Fragment Fusion Tracer and MnO2 Nanosheets for Detection of Deoxynivalenol in Corn Samples." Foods 13, no. 13 (2024): 2009. http://dx.doi.org/10.3390/foods13132009.

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Deoxynivalenol (DON) is a common mycotoxin that contaminates cereals. Therefore, the development of sensitive and efficient detection methods for DON is essential to guarantee food safety and human health. In this study, an enzyme cascade amplification-based immunoassay (ECAIA) using a dual-functional alkaline phosphatase-linked single-chain fragment variable fusion tracer (scFv-ALP) and MnO2 nanosheets was established for DON detection. The scFv-ALP effectively catalyzes the hydrolysis of ascorbyl-2-phosphate (AAP) to produce ascorbic acid (AA). This AA subsequently interacts with MnO2 nanosh

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Bao, Gegen, Shengyu Li, Qi Zhou, et al. "Transcriptomic Analysis Provides Insights into the Differential Effects of Aluminum on Peanut (Arachis hypogaea L.)." Genes 13, no. 10 (2022): 1830. http://dx.doi.org/10.3390/genes13101830.

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In acidic soils, high concentrations of aluminum ions (Al3+) in dissolved form reduce root growth and development of most crops. In addition, Al3+ is also a beneficial element in some plant species in low concentrations. However, the regulatory mechanism of the growth and development of peanut (Arachis hypogaea L.) treated with different concentrations of Al3+ has been rarely studied. In this study, peanut seedlings were treated with AlCl3.18H2O in Hoagland nutrient solution at four different concentrations of Al3+, i.e., 0 (pH 6.85), 1.25 (pH 4.03), 2.5 (pH 3.85), and 5 (pH 3.69) mmol/L, whic

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Gupta, Aradhna, and Bechan Sharma. "Evaluation of Levels of Phosphatases in the Lindane Exposed Fish, Channa punctatus." Journal of Biomedical Research & Environmental Sciences 4, no. 3 (2023): 555–61. http://dx.doi.org/10.37871/jbres1710.

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The alterations in the activities of acid and alkaline phosphatase are good indicators of stress due to the exposure of fish to any toxicant. The perturbations in their activities may result in the decreased immune responses and intestinal microflora activity. In the present study, the effect of sublethal concentrations of lindane (0.025, 0.05 and 0.1 mg/l) in different tissues of C. punctatus exposed for 96h has been studied. The data showed decrease in the acid phosphatase (AcP) activity in the following order: gills>muscle>heart>brain>kidney>liver, respectively, and for the A

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Bechan, Sharma. "Evaluation of Levels of Phosphatases in the Lindane Exposed Fish, Channa punctatus." J Biomed Res Environ Sci 4, no. 3 (2023): 555–61. https://doi.org/10.37871/jbres1710.

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The alterations in the activities of acid and alkaline phosphatase are good indicators of stress due to the exposure of fish to any toxicant. The perturbations in their activities may result in the decreased immune responses and intestinal microflora activity. In the present study, the effect of sublethal concentrations of lindane (0.025, 0.05 and 0.1 mg/l) in different tissues of C. punctatus exposed for 96h has been studied. The data showed decrease in the acid phosphatase (AcP) activity in the following order: gills>muscle>heart>brain>kidney>liver, respectively, and for the A

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Hanna, Atef N., W. James Waldman, John A. Lott, Stephen C. Koesters, Anna M. Hughes, and David J. Thornton. "Increased alkaline phosphatase isoforms in autoimmune diseases." Clinical Chemistry 43, no. 8 (1997): 1357–64. http://dx.doi.org/10.1093/clinchem/43.8.1357.

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Abstract We found significant increases in ALP and ALP isoform band 10 in the serum of patients with early insulin-dependent diabetes, rheumatoid arthritis, and in those with multiple sclerosis during periods of disease exacerbation as compared with healthy controls. The ALP isoforms were assayed by isoelectric focusing. Our data suggest that the increase in ALP and ALP-10 closely reflects the abnormal activation of T lymphocytes that is common in autoimmune diseases, and that the source of the ALP-10 is activated T lymphocytes. ALP-10 is a sensitive but nonspecific marker of an active autoimm

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Withold, W., U. Schulte, and H. Reinauer. "Method for determination of bone alkaline phosphatase activity: analytical performance and clinical usefulness in patients with metabolic and malignant bone diseases." Clinical Chemistry 42, no. 2 (1996): 210–17. http://dx.doi.org/10.1093/clinchem/42.2.210.

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Abstract We report the performance characteristics of an assay for determination of bone alkaline phosphatase (ALP) activity after immunoadsorption in microplate wells. Between-run imprecision was between 7.1% and 11.2%. The detection limit was 1.0 U/L. Comparisons with an immunoradiometric test for determination of bone ALP mass concentrations yielded the following regression equation: y = 3.11 + 1.33x with y, the bone ALP activity concentration (U/L) (and x, the bone ALP mass concentration microgram/L) (r +=0.974, n = 103). Using sera from patients with liver diseases and sera from patients

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Soltaninejad, Kambiz. "Current Status of Acute Aluminum Phosphide Poisoning in Iran: A Brief Review." International Journal of Forensic Sciences 9, no. 4 (2024): 1–5. https://doi.org/10.23880/ijfsc-16000415.

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Aluminum phosphide (AlP) (known as "rice tablet" in Iran), is an insecticide and rodenticide used to protect stored crops from pests. This pesticide is highly toxic to humans and has been the cause of many accidental and intentional poisonings, worldwide. Due to the high incidence of acute AlP poisoning and its mortality in Iran, the authorities banned sale and distribution of AlP tablets in 2007. The aim of this review is to evaluate the current status of acute AlP poisoning in Iran. The results shows that despite the prohibition of AlP tablets, the frequency of AlP acute poisonings is high i

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Valenzuela, G. J., L. A. Munson, N. M. Tarbaux, and J. R. Farley. "Time-dependent changes in bone, placental, intestinal, and hepatic alkaline phosphatase activities in serum during human pregnancy." Clinical Chemistry 33, no. 10 (1987): 1801–6. http://dx.doi.org/10.1093/clinchem/33.10.1801.

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Abstract To measure changes in bone alkaline phosphatase (EC 3.1.3.1) activity in serum as a function of duration of pregnancy, we adapted our existing alkaline phosphatase (ALP) isoenzyme assay (which has been used to measure bone, hepatic, and intestinal ALP activities in serum, in the absence of placental ALP) to allow quantification of individual ALP isoenzyme activities in the presence of placental ALP. The resulting CV for repeat measurements of bone ALP activity in artificial isoenzyme mixtures ranged from 23% for samples in which the bone isoenzyme represented 7% of total ALP activity

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Ohno, I., S. Mitsunaga, K. Nakachi, et al. "Clinical significance of serum alkaline phosphatase level in advanced pancreatic cancer." Journal of Clinical Oncology 29, no. 4_suppl (2011): 183. http://dx.doi.org/10.1200/jco.2011.29.4_suppl.183.

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183 Background: Alkaline phosphatase (ALP) is an enzyme that is elevated by various hepatobiliary diseases. Generally its elevation is thought to indicate bile stasis. There are some reports that show ALP is an important prognostic factor for several cancers such as colon, lung, and gastric cancer. Often it is speculated that ALP elevation indicates bile stasis caused by liver metastasis. However, the significance of ALP elevation in advanced pancreatic cancer (APC) patients is not well evaluated. The aim of this study was to determine the significance of elevated serum ALP as a prognostic fac

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Mestieri, Leticia Boldrin, Fabrício Mezzomo Collares, Ivana Maria Zaccara, et al. "Biological Properties of Experimental Methacrylate-Based Sealers Containing Calcium Phosphates." Brazilian Dental Journal 32, no. 1 (2021): 59–66. http://dx.doi.org/10.1590/0103-6440202103761.

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Abstract This study aimed to evaluate, in vitro and in vivo, the biocompatibility of experimental methacrylate-based endodontic sealers containing α-tricalcium phosphate (α-TCP) or nanostructured hydroxyapatite (HAp). Experimental methacrylate-based dual-cure sealers with the addition of α-TCP or HAp, at 10%wt were formulated and compared to AH Plus (AHP). Cell viability was assessed by 3-(4,5-dimethyl-thiazoyl)-2,5-diphenyl-tetrazolium bromide (MTT), and sulforhodamine B (SRB). Sealers were implanted in rats’ subcutaneous tissue and histologically evaluated. Bioactivity was assessed by alkali

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Jaskulska, Iwona, Joanna Lemanowicz, Bożena Dębska, Dariusz Jaskulski, and Barbara Breza-Boruta. "Changes in Soil Organic Matter and Biological Parameters as a Result of Long-Term Strip-Till Cultivation." Agriculture 13, no. 12 (2023): 2188. http://dx.doi.org/10.3390/agriculture13122188.

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The aim of the study was to determine the impact that three cultivation systems—conventional till (CT), reduced till (RT), and strip-till one-pass (ST-OP)—had on the biological parameters of the soil and their relationships with organic matter properties in the row zone (R) and inter-row zone (IR). For this purpose, a long-term static field experiment was carried out, from which soil samples were taken from a depth of 0–20 cm and the following were determined: TOC; TN content and fractional composition of organic matter; activity of dehydrogenases (DEHs), catalase (CAT), alkaline (AlP), and ac

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