Relevant bibliographies by topics / Alpha Amylase Inhibitor (AAI)

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  2. Dissertations / Theses
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Academic literature on the topic 'Alpha Amylase Inhibitor (AAI)'

Author: Grafiati
Published: 4 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "Alpha Amylase Inhibitor (AAI)"

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Alhakamy, Nabil Abdulhafiz, Gamal Abdallah Mohamed, Usama Ahmed Fahmy, et al. "New Alpha-Amylase Inhibitory Metabolites from Pericarps of Garcinia mangostana." Life 12, no. 3 (2022): 384. http://dx.doi.org/10.3390/life12030384.

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Two new benzophenones: garcimangophenones A (6) and B (7) and five formerly reported metabolites were purified from the pericarps EtOAc fraction of Garcinia mangostana ((GM) Clusiaceae). Their structures were characterized by various spectral techniques and by comparing with the literature. The α-amylase inhibitory (AAI) potential of the isolated metabolites was assessed. Compounds 7 and 6 had significant AAI activity (IC50 9.3 and 12.2 µM, respectively) compared with acarbose (IC50 6.4 µM, reference α-amylase inhibitor). On the other hand, 5 had a moderate activity. Additionally, their activi
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Mohamed, Gamal A., Ali A. Alqarni, Hossam M. Abdallah, Abdelsattar M. Omar, and Sabrin RM Ibrahim. "Cytotoxic and alpha amylase-inhibitory metabolites from Tagetes minuta: In vitro evaluation and docking studies." Tropical Journal of Pharmaceutical Research 22, no. 4 (2023): 795–804. http://dx.doi.org/10.4314/tjpr.v22i4.12.

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Purpose: To investigate the cytotoxic and alpha-amylase inhibitory (AAI) potential of methanol (MeOH) extract of T. minuta and its isolated metabolites. 
 Methods: Phytochemical investigation of MeOH extract of the aerial parts of T. minuta was accomplished using SiO2 and Rp-18 column chromatography (CC). The structures of the isolated metabolites were determined and verified based on various data, in addition to comparison with literature data. The metabolites were assessed for cytotoxic potential against HepG2, MCF-7, and HCT116 cell lines utilizing sulphur rhodamine B (SRB) assay. The
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Mohamed, Gamal A., and Sabrin R. M. Ibrahim. "Garcixanthone E and Garcimangophenone C: New Metabolites from Garcinia mangostana and Their Cytotoxic and Alpha Amylase Inhibitory Potential." Life 12, no. 11 (2022): 1875. http://dx.doi.org/10.3390/life12111875.

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Garcinia mangostana (Clusiaceae) is a rich pool of metabolites with diversified bioactivities. A new xanthone, garcixanthone E (1), and a new benzophenone, rhamnoside, as well as garcimangophenone C (9) together with garcinone E (2), α-mangostin (3), γ-mangostin (4), garcinone C (5), garcixanthone C (6), gartanin (7), and 2,4,6,3′,5′-pentahydroxybenzophenone (8) were purified from G. mangostana EtOAc extract. Their structural verification was accomplished utilizing assorted spectral tools and relating to the literature. The in vitro cytotoxic potential versus MCF-7, A549, and HCT-116 cell line
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Mohamed, Gamal A., Abdelsattar M. Omar, Moustafa E. El-Araby, Shaza Mass, and Sabrin R. M. Ibrahim. "Assessments of Alpha-Amylase Inhibitory Potential of Tagetes Flavonoids through In Vitro, Molecular Docking, and Molecular Dynamics Simulation Studies." International Journal of Molecular Sciences 24, no. 12 (2023): 10195. http://dx.doi.org/10.3390/ijms241210195.

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Diabetes is a chronic fast-growing metabolic disorder that is characterized by high blood glucose levels. Tagetes minuta L. has been used as a traditional remedy for various illnesses for many years, and, furthermore, its oil is used in the perfume and flavor industries. T. minuta contains various metabolites, such as flavonoids, thiophenes, terpenes, sterols, and phenolics, with varied bioactivities. Flavonoids can inhibit carbohydrate-digesting enzymes, such as alpha-amylase, which is a convenient dietary strategy for controlling hyperglycemia. In the current investigation, the isolated flav
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Fatoki, Oladotun A., and Anthony A. Onilude. "Characterisation of alpha-amylase inhibitor from Streptomyces xinghaiensis AAI2 in solid substrate." Scientific African 15 (March 2022): e01086. http://dx.doi.org/10.1016/j.sciaf.2021.e01086.

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Etsassala, Ninon G. E. R., Jelili A. Badmus, Jeanine L. Marnewick, et al. "Alpha-Glucosidase and Alpha-Amylase Inhibitory Activities, Molecular Docking, and Antioxidant Capacities of Plectranthus ecklonii Constituents." Antioxidants 11, no. 2 (2022): 378. http://dx.doi.org/10.3390/antiox11020378.

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Shortage in insulin secretion or degradation of produced insulin is the principal characteristic of the metabolic disorder of diabetes mellitus (DM). However, because the current medications for the treatment of DM have many detrimental side effects, it is necessary to develop more effective antidiabetic drugs with minimal side effects. Alpha-glucosidase and alpha-amylase inhibitors are directly implicated in the delay of carbohydrate digestion. Pharmacologically, these inhibitors could be targeted for the reduction in glucose absorption rate and, subsequently, decreasing the postprandial rise
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Nguyen, Thi Hanh, San-Lang Wang, Anh Dzung Nguyen та ін. "Novel α-Amylase Inhibitor Hemi-Pyocyanin Produced by Microbial Conversion of Chitinous Discards". Marine Drugs 20, № 5 (2022): 283. http://dx.doi.org/10.3390/md20050283.

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α-Amylase inhibitors (aAIs) have been applied for the efficient management of type 2 diabetes. The aim of this study was to search for potential aAIs produced by microbial fermentation. Among various bacterial strains, Pseudomonas aeruginosa TUN03 was found to be a potential aAI-producing strain, and shrimp heads powder (SHP) was screened as the most suitable C/N source for fermentation. P. aeruginosa TUN03 exhibited the highest aAIs productivity (3100 U/mL) in the medium containing 1.5% SHP with an initial pH of 7–7.5, and fermentation was performed at 27.5 °C for two days. Further, aAI compo
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Etsassala, Ninon G. E. R., Jelili A. Badmus, Jeanine L. Marnewick, Emmanuel I. Iwuoha, Felix Nchu, and Ahmed A. Hussein. "Alpha-Glucosidase and Alpha-Amylase Inhibitory Activities, Molecular Docking, and Antioxidant Capacities of Salvia aurita Constituents." Antioxidants 9, no. 11 (2020): 1149. http://dx.doi.org/10.3390/antiox9111149.

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Diabetes mellitus (DM) is one of the most dangerous metabolic diseases with a high rate of mortality worldwide. It is well known that insulin resistance and deficiency in insulin production from pancreatic β-cells are the main characteristics of DM. Due to the detrimental side effects of the current treatment, there is a considerable need to develop new effective antidiabetic drugs, especially alpha-glucosidase and alpha-amylase inhibitors with lesser adverse effects. These inhibitors are known to be directly involved in the delay of carbohydrate digestion, resulting in a reduction of glucose
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Abe, J., U. Sidenius та B. Svensson. "Arginine is essential for the α-amylase inhibitory activity of the α-amylase/subtilisin inhibitor (BASI) from barley seeds". Biochemical Journal 293, № 1 (1993): 151–55. http://dx.doi.org/10.1042/bj2930151.

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Treatment of barley alpha-amylase/subtilisin inhibitor (BASI) with reagents specific for arginine, histidine, methionine and tyrosine residues and amino and carboxyl groups indicates that an arginine residue(s) is essential for its action on the target enzyme barley alpha-amylase 2. Phenylglyoxal modified eight out of 12 arginine residues in BASI. Kinetic analysis shows that the inactivation of BASI follows a pseudo-first-order reaction and is due to reaction with one molecule of phenylglyoxal; the second-order rate constant is determined to be 2.95 M-1.min-1. At pH 8.0, BASI and barley alpha-
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Nagy-Gasztonyi, M., A. Nagy, E. Németh-SZerdahelyi, J. Pauk, and É. Gelencsér. "The activities of amylases and α-amylase inhibitor in wide-range herbicide resistant wheat lines." Czech Journal of Food Sciences 28, No. 3 (2010): 217–24. http://dx.doi.org/10.17221/125/2009-cjfs.

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The activities of total amylase, α-amylase, and α-amylase inhibitor in the albumin-globulin fractions of isogenic non transgenic control (CY 45) and ppt (phosphinothrichin) resistant transgenic spring wheat (Triticum aestivum L.) lines (T106, T116, T117, T124, T128, T129) were studied in two subsequent years. The plants were either sprayed with a selective herbicide Granstar (G), a wide range herbicide Finale 14 SL (F), or were grown without spraying (Q). Samples were obtained from field trial experiments of the Cereal Research Non Profit Co (Szeged, Hungary). Our results s
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Dissertations / Theses on the topic "Alpha Amylase Inhibitor (AAI)"

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Natarajan, M. "Effects of amylase inhibitor albumin from wheat on the alpha-amylase activity in carp and tilapia." Thesis, University of Stirling, 1988. http://hdl.handle.net/1893/1919.

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The amylolytic activities of alpha-amylase extracted from Mirror carp (Cyprinus carpio) and Nile tilapia (Oreochromis niloticus) were significantly reduced by purified amylase inhibitor albumin of wheat when tested under in vitro conditions. The action of this inhibitor was rapid and maximum levels of inhibition were attained within 20 minutes. For both carp and tilapia, the enzyme residual activities after inhibition were found to be related inversely to inhibitor concentration and positively to the initial enzyme activity levels. The curvilinear relationships between these parameters were ex
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Iguti, Antonia Miwa. "Caracterização e síntese dos inibidores de α-amilase do feijão (Phaseolus vulgaris)." Universidade de São Paulo, 1993. http://www.teses.usp.br/teses/disponiveis/9/9131/tde-10042013-132934/.

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Inibidores de alfa amilase de feijão (Phaseolus vulgaris) foram caracterizados. O inibidor da variedade Jalo apresentou peso molecular de 50kDa (por filtração em gel), ponto isoelétrico de 4,75 e 9,6% de carboidratos. O inibidor da variedade Argentino apresentou peso molecular de 48kDa, ponto isoelétrico de 4,90 e 7,6% de carboidratos. Ambos inibidores apresentaram pH ótimo de interação com alfa amilase pancreática de porco de 5,0 e, a pH 6,9, a complexação com a mesma enzima se deu na proporção de 1:1. Esses resultados, mais a composição de aminoácidos, indicaram que as características desses
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Menezes, Elizabete Wenzel de. "Efeito do inibidor de α-amilase do feijão (Phaseolus vulgaris L.) em Animais normais e diabéticos." Universidade de São Paulo, 1985. http://www.teses.usp.br/teses/disponiveis/9/9132/tde-03092012-163347/.

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Não consta resumo na publicação.<br>An &#945;-amylase inhibitor purified from black beans (Phaseolus vulgaris L.) prevents the utilization of starch either in normal or diabetic rats during short-time starch loading tests. It causes hypoglycaemia and alters accordingly the serum insulin and non esterified fatty acids levels. These effects are dose dependent and doses higher than 31 mg of the inhibitor can promote the complete smoothing on serum glucose level. The existence of starch in the presence of the inhibitor in the intestine doesn\'t alter the secretion or production of &#945;-amylase b
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Villalba, Cibeli May Arévalos. "ESTUDOS ESTRUTURAIS DE PROTEÍNAS: INIBIDOR DE ALFA-AMILASE DE Secale cereale, GTPase YchF E ENOLASE DE Trypanosoma cruzi." UNIVERSIDADE ESTADUAL DE PONTA GROSSA, 2012. http://tede2.uepg.br/jspui/handle/prefix/2100.

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Made available in DSpace on 2017-07-24T19:38:06Z (GMT). No. of bitstreams: 1 Cibeli May Villalba.pdf: 4939252 bytes, checksum: 5a6b5eaea0352844ad9868a7a9b79f0b (MD5) Previous issue date: 2012-03-13<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Proteins are the most abundant biomolecules in living organisms; they are present in all parts of a cell. They have different functions; their structural study is important because it brings greater insight into its functions and allows us to understand how they interact to each other and with the other molecules. Protein structur
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Halayko, Andrew John. "Characterization of the interaction of barley alpha-amylase II with an endogenous alpha-amylase inhibitor from barley kernels." 1988. http://hdl.handle.net/1993/16625.

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Gubbels, Sharon Margaret. "Localisation of barley [alpha]-amylase/subtilisin inhibitor, [alpha]-amylase and starch granules in developing and germinating barley kernels." 1992. http://hdl.handle.net/1993/18030.

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Audette, David Clare. "The association of an endogenous, proteinaceous alpha-amylase inhibitor with pre-harvest sprouting." 1990. http://hdl.handle.net/1993/16989.

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Jhong, Chien-Hung, and 鐘千虹. "Molecular docking for screening alpha-glucosidase and alpha-amylase inhibitor from natural compounds and investigating the glycemic effect." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/66983650927981776244.

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碩士<br>國立東華大學<br>生命科學系<br>100<br>The inhibitions of alpha-glucosidase and alpha-amylase activity in the digestive tract of humans are oral anti-diabetic drug used for controlling carbohydrates digest that are normally converted to simple sugars and are absorbed by intestine. However, diabetic patients suffer from hyperglycemia after meal, the clinical medicine-Acarbose is applied for therapy with gradually increasing dosage and induced-hypoglycemic side effect. The present study aimed to find out the alternative drug that can regulate the hyperglycemia by down-regulating alpha-glucosidase and a
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Chisholm, Joan. "The effect of Ca2+ and abscisic acid on synthesis of an endogenous [alpha]-amylase inhibitor in barley kernels." 1989. http://hdl.handle.net/1993/16836.

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Robertson, Masumi. "Effect of environment and ABA on [alpha]-amylase/subtilisin inhibitor accumulation during kernel development and early seedling growth in Hordeum vulgare L." 1989. http://hdl.handle.net/1993/16966.

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Books on the topic "Alpha Amylase Inhibitor (AAI)"

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Maskos, Klaus. The bifunctional [alpha]-amylase/trypsin inhibitor from Ragi: Three-dimensional structure, inhibitory properties and oxidative folding in vivo and in vitro. 1995.

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Book chapters on the topic "Alpha Amylase Inhibitor (AAI)"

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Hill, R. D., A. W. MacGregor, R. J. Weselake, and J. Daussant. "A Review of some Properties of an Endogenous Inhibitor of Cereal Alpha-Amylase." In Fourth International Symposium on Pre-Harvest Sprouting in Cereals. CRC Press, 2019. http://dx.doi.org/10.1201/9780429038471-48.

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Chrispeels, Maarten. "Transfer of Bruchid Resistance from the Common Bean to Other Starchy Grain Legumes by Genetic Engineering with the alpha-Amylase Inhibitor Gene." In Advances In Insect Control. CRC Press, 1997. http://dx.doi.org/10.1201/9780203211731.ch9.

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Conference papers on the topic "Alpha Amylase Inhibitor (AAI)"

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Kagawa, Masayuki, Zui Fujimoto, Mitsuru Momma, Kenji Takase, and Hiroshi Mizuno. "CRYSTAL STRUCTURE OF THE BACILLUS SUBTILIS ALPHA-AMYLASE COMPLEXED WITH THE INHIBITOR ACARBOSE." In XXIst International Carbohydrate Symposium 2002. TheScientificWorld Ltd, 2002. http://dx.doi.org/10.1100/tsw.2002.740.

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Aghajari, Nushin, Michel Roth, and Richard Haser. "EVIDENCE OF OLIGOSACCHARIDE SYNTHESIS BY CRYSTALS OF A COLD-ACTIVE ALPHA-AMYLASE: CHARACTERIZATION OF A NEW ALPHA-GLYCOSIDASE INHIBITOR." In XXIst International Carbohydrate Symposium 2002. TheScientificWorld Ltd, 2002. http://dx.doi.org/10.1100/tsw.2002.588.

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Svensson, Birte, Haruhide Mori, Birte Kramhoft, et al. "PROTEIN ENGINEERING OF CATALYTIC, SUGAR BINDING, AND PROTEINACEOUS INHIBITOR BINDING REGIONS IN BARLEY ALPHA-AMYLASE." In XXIst International Carbohydrate Symposium 2002. TheScientificWorld Ltd, 2002. http://dx.doi.org/10.1100/tsw.2002.480.

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Zhang, Haiping, Tingting Zhang, Konda Mani Saravanan, et al. "A novel virtual drug screening pipeline with deep-leaning as core component identifies inhibitor of pancreatic alpha-amylase." In 2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). IEEE, 2021. http://dx.doi.org/10.1109/bibm52615.2021.9669306.

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Wijayanti, Chandra, Nadia Rizky Putri Hapsari, Rina Rifqie Mariana, Suharti Suharti, and Subandi Subandi. "Total phenolic and total flavonoid content of sugar cane juice and their potency as alpha-amylase inhibitor and anti COVID-19." In INTERNATIONAL CONFERENCE ON LIFE SCIENCES AND TECHNOLOGY (ICoLiST 2020). AIP Publishing, 2021. http://dx.doi.org/10.1063/5.0052656.

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Journal articles
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