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Journal articles on the topic 'Alpha Amylase Inhibitor (AAI)'

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Published: 4 June 2025
Last updated: 1 August 2025

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1

Alhakamy, Nabil Abdulhafiz, Gamal Abdallah Mohamed, Usama Ahmed Fahmy, et al. "New Alpha-Amylase Inhibitory Metabolites from Pericarps of Garcinia mangostana." Life 12, no. 3 (2022): 384. http://dx.doi.org/10.3390/life12030384.

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Two new benzophenones: garcimangophenones A (6) and B (7) and five formerly reported metabolites were purified from the pericarps EtOAc fraction of Garcinia mangostana ((GM) Clusiaceae). Their structures were characterized by various spectral techniques and by comparing with the literature. The α-amylase inhibitory (AAI) potential of the isolated metabolites was assessed. Compounds 7 and 6 had significant AAI activity (IC50 9.3 and 12.2 µM, respectively) compared with acarbose (IC50 6.4 µM, reference α-amylase inhibitor). On the other hand, 5 had a moderate activity. Additionally, their activi
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2

Mohamed, Gamal A., Ali A. Alqarni, Hossam M. Abdallah, Abdelsattar M. Omar, and Sabrin RM Ibrahim. "Cytotoxic and alpha amylase-inhibitory metabolites from Tagetes minuta: In vitro evaluation and docking studies." Tropical Journal of Pharmaceutical Research 22, no. 4 (2023): 795–804. http://dx.doi.org/10.4314/tjpr.v22i4.12.

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Purpose: To investigate the cytotoxic and alpha-amylase inhibitory (AAI) potential of methanol (MeOH) extract of T. minuta and its isolated metabolites. 
 Methods: Phytochemical investigation of MeOH extract of the aerial parts of T. minuta was accomplished using SiO2 and Rp-18 column chromatography (CC). The structures of the isolated metabolites were determined and verified based on various data, in addition to comparison with literature data. The metabolites were assessed for cytotoxic potential against HepG2, MCF-7, and HCT116 cell lines utilizing sulphur rhodamine B (SRB) assay. The
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3

Mohamed, Gamal A., and Sabrin R. M. Ibrahim. "Garcixanthone E and Garcimangophenone C: New Metabolites from Garcinia mangostana and Their Cytotoxic and Alpha Amylase Inhibitory Potential." Life 12, no. 11 (2022): 1875. http://dx.doi.org/10.3390/life12111875.

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Garcinia mangostana (Clusiaceae) is a rich pool of metabolites with diversified bioactivities. A new xanthone, garcixanthone E (1), and a new benzophenone, rhamnoside, as well as garcimangophenone C (9) together with garcinone E (2), α-mangostin (3), γ-mangostin (4), garcinone C (5), garcixanthone C (6), gartanin (7), and 2,4,6,3′,5′-pentahydroxybenzophenone (8) were purified from G. mangostana EtOAc extract. Their structural verification was accomplished utilizing assorted spectral tools and relating to the literature. The in vitro cytotoxic potential versus MCF-7, A549, and HCT-116 cell line
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4

Mohamed, Gamal A., Abdelsattar M. Omar, Moustafa E. El-Araby, Shaza Mass, and Sabrin R. M. Ibrahim. "Assessments of Alpha-Amylase Inhibitory Potential of Tagetes Flavonoids through In Vitro, Molecular Docking, and Molecular Dynamics Simulation Studies." International Journal of Molecular Sciences 24, no. 12 (2023): 10195. http://dx.doi.org/10.3390/ijms241210195.

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Diabetes is a chronic fast-growing metabolic disorder that is characterized by high blood glucose levels. Tagetes minuta L. has been used as a traditional remedy for various illnesses for many years, and, furthermore, its oil is used in the perfume and flavor industries. T. minuta contains various metabolites, such as flavonoids, thiophenes, terpenes, sterols, and phenolics, with varied bioactivities. Flavonoids can inhibit carbohydrate-digesting enzymes, such as alpha-amylase, which is a convenient dietary strategy for controlling hyperglycemia. In the current investigation, the isolated flav
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5

Fatoki, Oladotun A., and Anthony A. Onilude. "Characterisation of alpha-amylase inhibitor from Streptomyces xinghaiensis AAI2 in solid substrate." Scientific African 15 (March 2022): e01086. http://dx.doi.org/10.1016/j.sciaf.2021.e01086.

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6

Etsassala, Ninon G. E. R., Jelili A. Badmus, Jeanine L. Marnewick, et al. "Alpha-Glucosidase and Alpha-Amylase Inhibitory Activities, Molecular Docking, and Antioxidant Capacities of Plectranthus ecklonii Constituents." Antioxidants 11, no. 2 (2022): 378. http://dx.doi.org/10.3390/antiox11020378.

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Shortage in insulin secretion or degradation of produced insulin is the principal characteristic of the metabolic disorder of diabetes mellitus (DM). However, because the current medications for the treatment of DM have many detrimental side effects, it is necessary to develop more effective antidiabetic drugs with minimal side effects. Alpha-glucosidase and alpha-amylase inhibitors are directly implicated in the delay of carbohydrate digestion. Pharmacologically, these inhibitors could be targeted for the reduction in glucose absorption rate and, subsequently, decreasing the postprandial rise
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7

Nguyen, Thi Hanh, San-Lang Wang, Anh Dzung Nguyen та ін. "Novel α-Amylase Inhibitor Hemi-Pyocyanin Produced by Microbial Conversion of Chitinous Discards". Marine Drugs 20, № 5 (2022): 283. http://dx.doi.org/10.3390/md20050283.

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α-Amylase inhibitors (aAIs) have been applied for the efficient management of type 2 diabetes. The aim of this study was to search for potential aAIs produced by microbial fermentation. Among various bacterial strains, Pseudomonas aeruginosa TUN03 was found to be a potential aAI-producing strain, and shrimp heads powder (SHP) was screened as the most suitable C/N source for fermentation. P. aeruginosa TUN03 exhibited the highest aAIs productivity (3100 U/mL) in the medium containing 1.5% SHP with an initial pH of 7–7.5, and fermentation was performed at 27.5 °C for two days. Further, aAI compo
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8

Etsassala, Ninon G. E. R., Jelili A. Badmus, Jeanine L. Marnewick, Emmanuel I. Iwuoha, Felix Nchu, and Ahmed A. Hussein. "Alpha-Glucosidase and Alpha-Amylase Inhibitory Activities, Molecular Docking, and Antioxidant Capacities of Salvia aurita Constituents." Antioxidants 9, no. 11 (2020): 1149. http://dx.doi.org/10.3390/antiox9111149.

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Diabetes mellitus (DM) is one of the most dangerous metabolic diseases with a high rate of mortality worldwide. It is well known that insulin resistance and deficiency in insulin production from pancreatic β-cells are the main characteristics of DM. Due to the detrimental side effects of the current treatment, there is a considerable need to develop new effective antidiabetic drugs, especially alpha-glucosidase and alpha-amylase inhibitors with lesser adverse effects. These inhibitors are known to be directly involved in the delay of carbohydrate digestion, resulting in a reduction of glucose
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9

Abe, J., U. Sidenius та B. Svensson. "Arginine is essential for the α-amylase inhibitory activity of the α-amylase/subtilisin inhibitor (BASI) from barley seeds". Biochemical Journal 293, № 1 (1993): 151–55. http://dx.doi.org/10.1042/bj2930151.

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Treatment of barley alpha-amylase/subtilisin inhibitor (BASI) with reagents specific for arginine, histidine, methionine and tyrosine residues and amino and carboxyl groups indicates that an arginine residue(s) is essential for its action on the target enzyme barley alpha-amylase 2. Phenylglyoxal modified eight out of 12 arginine residues in BASI. Kinetic analysis shows that the inactivation of BASI follows a pseudo-first-order reaction and is due to reaction with one molecule of phenylglyoxal; the second-order rate constant is determined to be 2.95 M-1.min-1. At pH 8.0, BASI and barley alpha-
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10

Nagy-Gasztonyi, M., A. Nagy, E. Németh-SZerdahelyi, J. Pauk, and É. Gelencsér. "The activities of amylases and α-amylase inhibitor in wide-range herbicide resistant wheat lines." Czech Journal of Food Sciences 28, No. 3 (2010): 217–24. http://dx.doi.org/10.17221/125/2009-cjfs.

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The activities of total amylase, α-amylase, and α-amylase inhibitor in the albumin-globulin fractions of isogenic non transgenic control (CY 45) and ppt (phosphinothrichin) resistant transgenic spring wheat (Triticum aestivum L.) lines (T106, T116, T117, T124, T128, T129) were studied in two subsequent years. The plants were either sprayed with a selective herbicide Granstar (G), a wide range herbicide Finale 14 SL (F), or were grown without spraying (Q). Samples were obtained from field trial experiments of the Cereal Research Non Profit Co (Szeged, Hungary). Our results s
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11

UCHIDA, Riichiro, Shoichi TOKUTAKE, Yoshinori MOTOYAMA, Kenji HOSOI, and Nobuyuki YAMAJI. "Novel Selective Inhibitor of .ALPHA.-Amylase Isoenzymes." Biological & Pharmaceutical Bulletin 17, no. 7 (1994): 993–95. http://dx.doi.org/10.1248/bpb.17.993.

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12

Gerber, M., K. Naujoks, H. Lenz, and K. Wulff. "A monoclonal antibody that specifically inhibits human salivary alpha-amylase." Clinical Chemistry 33, no. 7 (1987): 1158–62. http://dx.doi.org/10.1093/clinchem/33.7.1158.

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Abstract Our monoclonal antibody 88E8 specifically binds to and inhibits human salivary alpha-amylase (EC 3.2.1.1) and cross reacts negligibly with the pancreatic isoenzyme, inhibiting it by less than 1%, as compared with about 90% for the salivary isoenzyme. The antibody binds the S1 and S2 types of salivary alpha-amylase, but no pancreatic alpha-amylase isoenzyme forms. A pancreatic alpha-amylase assay involving 88E8 is under development, with alpha-glucosidase as auxiliary enzyme and p-nitrophenyl-maltoheptaoside as substrate; we give preliminary data on this assay. The assay has to be done
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13

Silva, Maria Cristina Mattar da, Luciane Vieira Mello, Marise Ventura Coutinho, et al. "Mutants of common bean alpha-amylase inhibitor-2 as an approach to investigate binding specificity to alpha-amylases." Pesquisa Agropecuária Brasileira 39, no. 3 (2004): 201–8. http://dx.doi.org/10.1590/s0100-204x2004000300001.

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Despite the presence of a family of defense proteins, Phaseolus vulgaris can be attacked by bruchid insects resulting in serious damage to stored grains. The two distinct active forms of a-amylase inhibitors, a-AI1 and a-AI2, in P. vulgaris show different specificity toward a-amylases. Zabrotes subfasciatus a-amylase is inhibited by a-AI2 but not by a-AI1. In contrast, porcine a-amylase is inhibited by a-AI1 but not by a-AI2. The objective of this work was to understand the molecular basis of the specificity of two inhibitors in P. vulgaris (a-AI1 and a-AI2) in relation to a-amylases. Mutants
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14

Uchida, R., S. Tokutake, Y. Motoyama, K. Hosoi, and N. Yamaji. "Automated measurement of alpha-amylase isoenzymes with 6(3)-deoxymaltotriose as selective amylase inhibitor." Clinical Chemistry 41, no. 4 (1995): 519–22. http://dx.doi.org/10.1093/clinchem/41.4.519.

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Abstract We developed an automated method for measurement of alpha-amylase isoenzymes in serum by a single kinetic assay (SKA) and a double kinetic assay (DKA) with 2-chloro-4-nitrophenyl-6(5)-azido-6(5)-deoxy-beta-maltopentaoside as a substrate and 6(3)-deoxymaltotriose (DOG3) as a novel selective amylase inhibitor. DOG3 showed a large difference in inhibitory activity between human pancreatic alpha-amylase (HPA; 86.9% inhibition) and salivary alpha-amylase (32.1% inhibition) at 0.33 mmol/L. Constant inhibition was obtained immediately after addition of DOG3. The inhibitory effect did not cha
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15

Uthman H. "Kinetic Studies on the Inhibition Potential of Bitter Leaf (Vernonia Amygdalin) in the Management of Diabetes." GSC Advanced Research and Reviews 21, no. 3 (2024): 184–97. https://doi.org/10.30574/gscarr.2024.21.3.0483.

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The aim of this study was to investigate the inhibition potential of extracts from Vernonia amygdalina on α-amylase and α-glucosidase activity, and its useful mechanisms in the treatment of diabetes specifically Type 2. The searchlight is beamed on the potential of the plant extract to inhibit the activity of α-amylase and thereby determining its mechanism or mode on inhibition as well as its IC50 value. The inhibition of alpha-amylase and alpha-glucosidase enzymes is a key strategy in managing diabetes. Vernonia amygdalina is a natural plant extract that has been used traditionally to manage
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16

JAWAHAR VELLAISAMY and SOLAIJAYALAKSHMI SOLAIYAPPAN. "Synergistic effect of grape seed extract in combination with green coffee bean for the treatment of diabetes mellitus." World Journal of Biology Pharmacy and Health Sciences 23, no. 1 (2025): 272–78. https://doi.org/10.30574/wjbphs.2025.23.1.0671.

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The proposed project successful attempt has been made to synergistic effect of grape seed extract in combination with green coffee bean for the treatment of diabetes mellitus. I started process plant extraction is a modern technique that offers a rapid method for extraction phytoconstituents. Coffee arabica extract percentage yield 11.44% and grape seed extract percentage yield 10.23% mixture of these two extract were taken 1:1 ratio for the present study to find the synergistic anti diabetic activity phytochemical study conducted to investigate the present various components CBGSC and process
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17

Siregar, Pebrianiafrahul I., Sri Pujiyanto, and Arina Tri Lunggani. "Inhibitory activity of endophytic fungi against alpha-amylase isolated from raru (Cotylelobium melanoxylon)." Berkala Penelitian Hayati 28, no. 1 (2022): 44–50. http://dx.doi.org/10.23869/bphjbr.28.1.20227.

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Diabetes mellitus is a metabolic disorder characterized by elevated blood glucose levels. Alpha-amylase inhibitors are chemicals that prevent amylase from degrading carbohydrates into monosaccharides. For instance, the Raru plant (Cotylelobium melanoxylon), which was widely used by the local people, particularly in Sumatra, was used to lower blood glucose levels. The goal of this study was to isolate an endophytic fungus from the Raru plant and test its alpha-amylase activity by optimizing treatment time, substrate concentration, and alpha-amylase inhibitor compound extraction. The activity of
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18

Masojc, P., J. Zawistowski, and U. Zawistowska. "Polymorphism of Endogenous Alpha-amylase Inhibitor in Barley." Journal of Cereal Science 20, no. 1 (1994): 43–49. http://dx.doi.org/10.1006/jcrs.1994.1043.

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19

Jarrett, S. J., RJ Marschke, M. H. Symons, C. E. Gibson, R. J. Henry, and G. P. Fox. "Alpha-amylase/subtilisin Inhibitor Levels in Australian Barleys." Journal of Cereal Science 25, no. 3 (1997): 261–66. http://dx.doi.org/10.1006/jcrs.1996.0084.

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20

GOTO, Akira, Yoshihiro MATSUI, Kunio OHYAMA, Motoo ARAI, and Sawao MURAO. "Studies on an animal .ALPHA.-amylase inhibitor (Haim) from Streptomyces griseosporeus YM-25. Part III. Inhibitory effects of the proteinaceous .ALPHA.-amylase inhibitor Haim on animal .ALPHA.-amylase." Agricultural and Biological Chemistry 49, no. 2 (1985): 435–39. http://dx.doi.org/10.1271/bbb1961.49.435.

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21

Tsvetkov, V. O., V. O. Maksutova, and L. G. Yarullina. "In silico study of the Colorado potato beetle alpha-amylase structure and its interaction with inhibitors." Biomics 12, no. 4 (2020): 442–48. http://dx.doi.org/10.31301/2221-6197.bmcs.2020-35.

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To develop effective and environmentally friendly methods for protecting crop plants from pests, it is necessary to know the structure of pests hydrolases and the mechanisms of their interaction with plant inhibitors. The aim of this work was a modeling of the spatial structure of Colorado potato beetle alpha-amylase, analysis of the effect of revealed structural features on interaction with protein inhibitors, as well as modeling of interaction with amylase inhibitors from various organisms.The spatial structure of the Colorado potato beetle alpha-amylase was obtained by the method of compute
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22

Jadalla, Baraa M. I. S., Justin J. Moser, Rajan Sharma, et al. "In Vitro Alpha-Glucosidase and Alpha-Amylase Inhibitory Activities and Antioxidant Capacity of Helichrysum cymosum and Helichrysum pandurifolium Schrank Constituents." Separations 9, no. 8 (2022): 190. http://dx.doi.org/10.3390/separations9080190.

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Diabetes mellitus (DM) is a group of systemic metabolic disorders with a high rate of morbidity and mortality worldwide. Due to the detrimental side effects of the current treatment, there is a great need to develop more effective antidiabetic drugs with fewer side effects. Natural products are a well-known source for the discovery of new scaffolds for drug discovery, including new antidiabetic drugs. The genus Helichrysum has been shown to produce antidiabetic natural products. In this investigation, the methanolic extract of H. cymosum and H. pandurifolium resulted in the isolation and ident
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23

Omar, Abdelsattar M., Dana F. AlKharboush, Khadijah A. Mohammad, Gamal A. Mohamed, Hossam M. Abdallah, and Sabrin R. M. Ibrahim. "Mangosteen Metabolites as Promising Alpha-Amylase Inhibitor Candidates: In Silico and In Vitro Evaluations." Metabolites 12, no. 12 (2022): 1229. http://dx.doi.org/10.3390/metabo12121229.

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Diabetes is a chronic metabolic disorder characterized by raised glucose levels in the blood, resulting in grave damage over time to various body organs, including the nerves, heart, kidneys, eyes, and blood vessels. One of its therapeutic treatment approaches involves the inhibition of enzymes accountable for carbohydrate digestion and absorption. The present work is aimed at evaluating the potential of some reported metabolites from Garcinia mangostana (mangosteen, Guttiferae) as alpha-amylase inhibitors. Forty compounds were assessed for their capacity to inhibit alpha-amylase using in sili
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24

Hồ, Thị Thanh Thanh, Thị Huyền Thoa Phạm, Thị Tú Oanh Nguyễn, Anh Dũng Nguyễn, and Văn Bốn Nguyễn. "The potential inhibiton against enzymes target type 2 diabetes's pathways of leonuriside via virtual studies." Tạp Chí Khoa Học Tây Nguyên (Tay Nguyen Journal of Science) 18, no. 3 (2024): 11–18. https://doi.org/10.5281/zenodo.12720643.

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Leonuriside (LN) is a natural compound previously purified from Euonymus laxiflorus Champ. and was found as a novel inhibitor of enzyme-targeting type 2 diabetes (T2D) treatment in our early reports via in vitro tests. This study aims to further characterize LN as a potential inhibitor of α-glucosidase and α-amylase and its high possibility of being developed as an antidiabetic drug via in silico studies. The result of the docking study indicated that LN could bind to targeting enzymes α-glucosidase (Q6P7A9) and α-amylase (1SMD) via forming stable complexes with accepta
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25

GOTO, Akira, Motoo ARAI, and Sawao MURAO. "Application of the proteinaceous .ALPHA.-amylase inhibitor Haim to horse and carp .ALPHA.-amylase purification and some properties of the purified .ALPHA.-amylase." Journal of the agricultural chemical society of Japan 59, no. 4 (1985): 411–17. http://dx.doi.org/10.1271/nogeikagaku1924.59.411.

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26

Durgam, Mohan Krishna, Praveen Kumar Vemuri, Vijaya Lakshmi Bodiga, and Sreedhar Bodiga. "Lupenone Isolated from Diospyros melanoxylon Bark Non-competitively Inhibits alpha-amylase Activity." Biology, Medicine, & Natural Product Chemistry 12, no. 1 (2023): 171–76. http://dx.doi.org/10.14421/biomedich.2023.121.171-176.

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Diabetes mellitus is a chronic disease that poses a serious global health problem, due to its associated effects on obesity and aging. Therapeutic strategies for targeting diabetes include the downregulation and/or inhibition of enzymes such as a-amylase and a-glucosidase, hydrolyzing the dietary carbohydrates in intestine. There is increasing interest for a-amylase inhibitors from natural sources. Our objective was to undertake the phytochemical screening of bark extracts of Diospyros melanoxylon for potential a-amylase inhibitory activity and further identification of the active principle an
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27

Samanta, Saptadip, Subhajit Jana, Sanjay Kar, Pradeep Kumar Das Mohapatra, Bikash Ranjan Pati, and Keshab Chandra Mondal. "Induction and catabolite repression of alpha-amylase synthesis in Bacilluslicheniformis SKB4." Journal of Microbiology and Biotechnology Research 7, no. 6 (2017): 8. http://dx.doi.org/10.24896/jmbr.2017762.

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Microbial amylases have an exciting potentiality and are being used extensively in different industries. In this study, regulation of amylase biosynthesis was examined in Bacillus licheniformis SKB4 (wild type) and its mutant strain (8b). The mutant strain was developed by using UV exposure. Expression of the a-amylase gene of Bacillus licheniformis was activated by inducer and subject to catabolite repression. Addition of exogenous glucose or sucrose repressed bio-synthesis of a-amylase which was concentration (0.05-1.0% w/v) dependent. However, mutant strain could enable to overrule the gluc
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28

Sanchez-Monge, R., L. Gomez, D. Barber, C. Lopez-Otin, A. Armentia та G. Salcedo. "Wheat and barley allergens associated with baker's asthma. Glycosylated subunits of the α-amylase-inhibitor family have enhanced IgE-binding capacity". Biochemical Journal 281, № 2 (1992): 401–5. http://dx.doi.org/10.1042/bj2810401.

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A 16 kDa protein, designated CM16*, which strongly binds IgE from baker's-asthma patients has been identified as a glycosylated form of the previously reported WTAI-CM16, which is a subunit of the wheat tetrameric alpha-amylase inhibitor. A glycosylated form (CMb*) of BTAI-CMb, the equivalent inhibitor subunit from barley, has been also found to have significantly enhanced IgE-binding capacity. In all, 14 purified members of the alpha-amylase/trypsin-inhibitor family showed very different IgE-binding capacities when tested by a dot-blot assay. The glycosylated components CM16*, CMb* and the pr
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29

Han, Guang-Xin, Ming-Sheng Zhu, and Herbert W. Levi. "alpha-amylase inhibitor Parvulustat (Z-2685) from Streptomyces parvulus." Zootaxa 2297 (November 25, 2009): 55–63. https://doi.org/10.13018/bmr16157.

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Han, Guang-Xin, Zhu, Ming-Sheng, Levi, Herbert W. (2009): alpha-amylase inhibitor Parvulustat (Z-2685) from Streptomyces parvulus. Zootaxa 2297: 55-63, DOI: 10.13018/bmr16157, URL: http://dx.doi.org/10.13018/bmr16157
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30

Gaikwad, Dinanath T., Suraj P. Bansode, Dipak P. Mali, Ganesh H. Wadkar, Vijaykumar T. Pawar, and Firoj A. Tamboli. "Promising Discovery of Alpha Amylase Enzyme Inhibitors from Terminalia arjuna for Antidiabetic Potential." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 12, no. 03 (2022): 1020–24. http://dx.doi.org/10.25258/ijddt.12.3.17.

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The aim of this work was to discover alpha amylase inhibitors from selected phytoconstituents of Terminalia arjuna by utilizing computational and in-silico methodology. Identified 37 phytoconstituents of T. arjuna were docked as test molecules. The complex structure of alpha-amylase in associated with Acarviostatin I03 was retrieved from protein data bank. Molecular screening by GA-based was performed to generate the cavity-enabled complex prototype using VLife MDS 4.4 software. Docking was used to identify the potent alpha-amylase inhibitor. Ligand-enzyme poses of the selected T. arjuna phyto
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ARAI, Motoo, Naoki OOUCHI, Akira GOTO, Sei OGURA, and Sawao MURAO. "Chemical modification of haim, a proteinaceous .ALPHA.-amylase inhibitor." Agricultural and Biological Chemistry 49, no. 5 (1985): 1523–24. http://dx.doi.org/10.1271/bbb1961.49.1523.

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32

Zaynullin, Radik A., Raikhana V. Kunakova, Elza K. Khusnutdinova, et al. "Dihydroquercetin: known antioxidant—new inhibitor of alpha-amylase activity." Medicinal Chemistry Research 27, no. 3 (2017): 966–71. http://dx.doi.org/10.1007/s00044-017-2119-z.

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33

Zaynutdinova, Gulnozaxon Fahriddin kizi. ""DETERMINATION OF A-AMYLASE ENZYME, ANTIOXIDANT ACTIVITY, ANTIBACTERIAL ACTIVITY USING CERTAIN MEDICINAL PLANTS"." INNOVATIVE RESEARCH IN SCIENCE 1, no. 14 (2022): 125–28. https://doi.org/10.5281/zenodo.7115008.

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The Inhibition of carbohydrate-hydrolyzing enzymes such as α-amylase in patients with type II diabetes can be an important strategy in the level of blood glucose after a meal, plants for α-amylase inhibition contains various chemical constituents with potential and therefore therapeutic use possible. Nine types of plants include (Clove, Lemon, Chamomile, Radish, Ginger, Black seed, pomegranate, Beetroot and Garlic) were used in this study to select the optimum plant material that inhibited α- amylase enzyme. Raphanus raphanistrum was chosen, it had the highest inhibition acti
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34

Karray, Aida, Mona Alonazi, Raida Jallouli, Humidah Alanazi, and Abir Ben Bacha. "A Proteinaceous Alpha-Amylase Inhibitor from Moringa Oleifera Leaf Extract: Purification, Characterization, and Insecticide Effects against C. maculates Insect Larvae." Molecules 27, no. 13 (2022): 4222. http://dx.doi.org/10.3390/molecules27134222.

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The main objective of the current study was the extraction, purification, and enzymatic characterization of a potent proteinaceous amylase inhibitor from Moringa oleifera. The antimicrobial potential and insecticide effects against C. maculates insect larvae were also studied. The α-amylase inhibitor was extracted in methanol (with an inhibitory activity of 65.6% ± 4.93). Afterwards, the inhibitor αAI.Mol was purified after a heat treatment at 70 °C for 15 min followed by one chromatographic step of Sephadex G-50. An apparent molecular weight of 25 kDa was analyzed, and the N-terminal sequence
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Daily, Michael F., Virginia H. Latham, Claudia M. Garcia, et al. "Producing exposed cota-free embryos." Zygote 2, no. 3 (1994): 221–25. http://dx.doi.org/10.1017/s096719940000201x.

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SummaryProduction of embryos that are free of tough outer coats facilitates studies that are not possible with embryos surrounded by impenetrable envelopes. This report describes a new procedure for preventing formation of fertilisation membranes in the sea urchin (Lytechinus pictus) model. This procedure involves treating unfertilised eggs with the enzyme alpha-amylase, which cleaves alpha-1,4 glucosidic bonds in the vitelline layer. A major advantage of this method is that it is very well defined and completely controllable with alpha-amylase inhibitor. The results suggest that intact alpha-
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36

Ahmed, Maryam Usman, Martha Ignatus, Benjamin Yakubu, et al. "Alpha amylase and angiotensin converting enzyme inhibitory potential of aqueous extract of Azanza garckeana fruit." Journal of Applied and Natural Science 14, no. 2 (2022): 283–88. http://dx.doi.org/10.31018/jans.v14i2.3305.

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Diabetes mellitus and hypertension are common diseases affecting a lot of people. Alpha amylase and angiotensin-converting enzyme (ACE) inhibitors are used to treat type II diabetes and hypertension respectively. This study investigated the alpha amylase and ACE inhibitory potential of Azanza garckeana fruits. Phytochemical screening, α-amylase and ACE inhibitory potential of the aqueous extract of A. garckeana fruit was determined using standard procedures. The mode of inhibition of α-amylase by A. garckeana fruit was determined from the Lineweaver-Burk plot. Alkaloids, flavonoids, anthraquin
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Zapatero, L., M. I. Martinez, E. Alonso, et al. "Oral wheat flour anaphylaxis related to wheat alpha-amylase inhibitor subunits CM3 and CM16. Wheat alpha-amylase inhibitor subunits related to food allergy." Allergy 58, no. 9 (2003): 956. http://dx.doi.org/10.1034/j.1398-9995.2003.00158.x.

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38

Zhi-Fei, Zhu, Ning Ting-Ting, Xu Zu-Min, Zhang Ge-Xin, and Ma Yan-He. "The Crystal Water Affect in the Interaction between the Tenebrio Molitor Alpha-Amylase and Its Inhibitor." Bioinorganic Chemistry and Applications 2008 (2008): 1–6. http://dx.doi.org/10.1155/2008/469062.

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Molecular dynamics simulation of the interaction between the Tenebrio molitor alpha-amylase and its inhibitor at different proportion of crystal water was carried out with OPLS force field by hyperchem 7.5 software. In the correlative study, the optimal temperature of wheat monomeric and dimeric protein inhibitors was from 273 K to 318 K. The the average temperature of experimentation is 289 K. (1) The optimal temperature of interaction between alpha-amylase and its inhibitors was 280 K without crystal water that was close to the results of experimentation. The forming of enzyme-water and inhi
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39

Zółtowska, K. "Purification and characterization of alpha-amylases from the intestine and muscle of ascaris suum (Nematoda)." Acta Biochimica Polonica 48, no. 3 (2001): 763–74. http://dx.doi.org/10.18388/abp.2001_3911.

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Alpha-Amylase (EC 3.2.1.1) was purified from the muscle and intestine of the parasitic helminth of pigs Ascaris suum. The enzymes from the two sources differed in their properties. Isoelectric focusing revealed one form of a-amylase from muscles with pl of 5.0, and two forms of amylase from intestine with pI of 4.7 and 4.5. SDS/PAGE suggested a molecular mass of 83 kDa and 73 kDa for isoenzymes of a-amylases from intestine and 59 kDa for the muscle enzyme. Alpha-Amylase from intestine showed maximum activity at pH 7.4, and the enzyme from muscle at pH 8.2. The muscle enzyme was more thermostab
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40

Laatikainen, Reijo. "Comment on Huang, X., et al. “Sourdough Fermentation Degrades Wheat Alpha-Amylase/Trypsin Inhibitor (ATI) and Reduces Pro-Inflammatory Activity”. Foods 2020, 9, 943." Foods 9, no. 10 (2020): 1404. http://dx.doi.org/10.3390/foods9101404.

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41

Reka, P., Thahira Banu A., and M. Seethalakshmi. "ALPHA AMYLASE AND ALPHA GLUCOSIDASE INHIBITION ACTIVITY OF SELECTED EDIBLE SEAWEEDS FROM SOUTH COAST AREA OF INDIA." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 6 (2017): 64. http://dx.doi.org/10.22159/ijpps.2017v9i6.17684.

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Objective: The present work was to investigate the alpha amylase and alpha-glucosidase inhibitory activity of the selected edible seaweeds.Methods: The seaweeds namely Acanthophora spicifera, Gracilaria corticata, Gracilaria edulis, Ulva lactuca and Ulva reticulata were selected for this study. Six and eight hours of ethanol and aqueous extract were used for the estimation of alpha amylase using DNS method and alpha-glucosidase inhibition activity.Results: The study reported that the solvent from ethanol and aqueous in eight hours of extraction showed a higher inhibitory activity than six hour
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42

Reddy, M. K., G. D. Heda та J. K. Reddy. "Purification and characterization of α-amylase from rat pancreatic acinar carcinoma. Comparison with pancreatic α-amylase". Biochemical Journal 242, № 3 (1987): 681–87. http://dx.doi.org/10.1042/bj2420681.

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alpha-Amylase was purified to apparent homogeneity from normal pancreas and a transplantable pancreatic acinar carcinoma of the rat by affinity chromatography on alpha-glucohydrolase inhibitor (alpha-GHI) bound to aminohexyl-Sepharose 4B. Recovery was 95-100% for both pancreas and tumour alpha-amylases. They were monomeric proteins, with Mr approx. 54000 on SDS/polyacrylamide-gel electrophoresis. Isoelectric focusing of both normal and tumour alpha-amylases resolved each into two major isoenzymes, with pI 8.3 and 8.7. Tumour-derived alpha-amylase contained two additional minor isoenzymes, with
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YOKOTA, Takashi, Osamu KIRIHARA, Hifumi OHISHI, Hisanori TANI, Kenji WATANABE, and Hiroshi OHAMI. "Anti-obesity Effects of .ALPHA.-Amylase Inhibitor from Wheat Flour." Nippon Eiyo Shokuryo Gakkaishi 47, no. 5 (1994): 341–48. http://dx.doi.org/10.4327/jsnfs.47.341.

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44

Chagolla-Lopez, A., A. Blanco-Labra, A. Patthy, R. Sánchez, and S. Pongor. "A novel alpha-amylase inhibitor from amaranth (Amaranthus hypocondriacus) seeds." Journal of Biological Chemistry 269, no. 38 (1994): 23675–80. http://dx.doi.org/10.1016/s0021-9258(17)31568-5.

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45

Prasetyawan, Sasangka, Anna Safitri, and Sri Rahayu. "Computational study of Curcuma zanthorrhiza Roxb compounds as potential antidiabetic towards alpha-amylase, alpha-glucosidase, and Keap1 inhibition." Journal of Pharmacy & Pharmacognosy Research 10, no. 2 (2022): 206–17. http://dx.doi.org/10.56499/jppres21.1175_10.2.206.

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Context: Curcuma zanthorrhiza Roxb is traditionally used as a medicinal herb that is believed might cure some diseases. However, there is still a lack of information about the underlying mechanism of bioactive compounds from C. zanthorrhiza, which has antidiabetic properties. Aims: To analyze the bioactive compounds of C. zanthorrhiza as inhibitors of alpha-amylase, alpha-glucosidase, and Keap1, which play a significant role in diabetes mellitus (DM) progression. Methods: The bioactive compounds of C. zanthorrhiza were screened its antidiabetic activity by PASS server. To determine the interac
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Deshpande, S. S., and C. G. Campbell. "Genotype variation in BOAA, condensed tannins, phenolics and enzyme inhibitors of grass pea (Lathyrus sativus)." Canadian Journal of Plant Science 72, no. 4 (1992): 1037–47. http://dx.doi.org/10.4141/cjps92-130.

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Genotypic variability in the neurotoxin, beta-N-oxalyl-amino-L-alanine (BOAA), condensed tannins and phenolics, and protein inhibitors of trypsin, chymotrypsin and alpha-amylase was investigated in 100 lines of Lathyrus sativus (grass pea) germplasm maintained at the Morden Research Station. The ranges for these antinutrients (overall means in the parentheses) were as follows: BOAA 0.22–7.20 (2.95) g kg−1, condensed tannins 0.0–4.38 (1.17) g kg−1, trypsin inhibitor 133–174 (155) units mg−1, chymotrypsin inhibitor 0–23 (10) units mg−1, and alpha-amylase inhibitor 3.6–91.4 (35.2) units g−1. Cond
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47

Ahmed, Sabbir, Md Chayan Ali, Rumana Akter Ruma, et al. "Molecular Docking and Dynamics Simulation of Natural Compounds from Betel Leaves (Piper betle L.) for Investigating the Potential Inhibition of Alpha-Amylase and Alpha-Glucosidase of Type 2 Diabetes." Molecules 27, no. 14 (2022): 4526. http://dx.doi.org/10.3390/molecules27144526.

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Piper betle L. is widely distributed and commonly used medicinally important herb. It can also be used as a medication for type 2 diabetes patients. In this study, compounds of P. betle were screened to investigate the inhibitory action of alpha-amylase and alpha-glucosidase against type 2 diabetes through molecular docking, molecular dynamics simulation, and ADMET (absorption, distribution, metabolism, excretion, and toxicity) analysis. The molecule apigenin-7-O-glucoside showed the highest binding affinity among 123 (one hundred twenty-three) tested compounds. This compound simultaneously bo
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48

Pierzynowska, Kateryna, Sofia Thomasson, and Stina Oredsson. "Alpha-Amylase Inhibits Cell Proliferation and Glucose Uptake in Human Neuroblastoma Cell Lines." BioMed Research International 2022 (July 25, 2022): 1–11. http://dx.doi.org/10.1155/2022/4271358.

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The present article describes a study of the effects of alpha-amylase (α-amylase) on the human neuroblastoma (NB) cell lines SH-SY5Y, IMR-32, and LA-N-1. NB is the most common malignancy diagnosed in infants younger than 12 months. Some clinical observations revealed an inverse association between the risk of NB development and breastfeeding. α-Amylase which is present in breast milk was shown to have anticancer properties already in the beginning of the 20th century. Data presented here show that pancreatic α-amylase inhibits cell proliferation and has a direct impact on glucose uptake in the
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Valencia-Jiménez, A., J. W. Arboleda V, A. López Ávila та M. F. Grossi-de-Sá. "Digestive α-amylases from Tecia solanivora larvae (Lepidoptera: Gelechiidae): response to pH, temperature and plant amylase inhibitors". Bulletin of Entomological Research 98, № 6 (2008): 575–79. http://dx.doi.org/10.1017/s0007485308005944.

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AbstractThe biochemical properties of the digestive alpha-amylase from Tecia solanivora larvae, an important and invasive insect pest of potato (Solanum tuberosum), were studied. This insect has three major digestive α-amylases with isoelectric points 5.30, 5.70 and 5.98, respectively, which were separated using native and isoelectric focusing gels. The alpha-amylase activity has an optimum pH between 7.0 and 10.0 with a peak at pH 9.0. The enzymes are stable when heated to 50°C and were inhibited by proteinaceous inhibitors from Phaseolus coccineus (70% inhibition) and P. vulgaris cv. Radical
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50

Dinnar, Normaita Latiefah. "Uji aktivitas penghambatan enzim alfa amilase ekstrak dan fraksi daun binahong merah (anredera cordifolia (ten.) Steenis)." Jurnal Indonesia Sosial Sains 3, no. 10 (2022): 1361–76. http://dx.doi.org/10.59141/jiss.v3i10.718.

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Diabetes mellitus (DM) is a chronic metabolic disorder, characterized by high levels of glucose in the blood (hyperglycemia) caused by decreased insulin secretion. One way to treat diabetes mellitus is to reduce postprandial glucose levels, which is to slow down glucose absorption through the inhibition of the alpha amylase enzyme. Alpha amylase inhibitors are compounds that can inhibit the breakdown of carbohydrates into glucose by the enzyme alpha amylase. One of the plants that have a hyperglycemic effect is red binahong (Anredera cordifolia (Ten.) Steenis). This study aimed to determine th
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