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Dissertations / Theses on the topic 'Alpha glycosidase'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Smith, Nigel K. "The synthesis of novel oligosaccharides using the glycosidase #alpha#-mannosidase." Thesis, University of Westminster, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362691.

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2

Lodge, Jacinta. "The crystal structure of [alpha]-glucosidase [alpha-glucosidase] A, AglA, from Thermotoga maritima the first structure of a family 4 glycosyl hydrolase defines a new glycosidase clan /." [S.l. : s.n.], 2003. http://www.diss.fu-berlin.de/2004/95/index.html.

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3

Glawar, Andreas Felix Gregor. "Design, synthesis and biological evaluation of glycosidase inhibitors in an anti-cancer setting." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:602edf26-d9ff-4fcf-8dec-c8548f3578da.

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The aim of the work described in this thesis was to explore the synthesis of glycosidase inhibitors and to evaluate their potential as anti-cancer agents. Glycosidases catalyze the fission of glycosidic bonds and are involved in vital biological functions. With regard to their potential for anti-cancer therapy, two glycosidases were identified: α-N-acetyl-galactosaminidase and β-N-acetyl-hexosaminidase. The former has been implicated in causing immunosuppression in advanced cancer patients by negating the effect of the macrophage activating factor (MAF), while the latter is secreted by invadin

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4

Souza, Ana Marla Duarte de. "Compostos bioativos com potencial ação no controle da homeostase glicêmica." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/9/9131/tde-05062017-165732/.

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Diversos estudos buscam identificar novas moléculas com ações regulatórias sobre a via de sinalização da insulina e consequentemente na homeostase da glicose. Assim, este trabalho visa avaliar o potencial de extratos de frutos no controle da homeostase glicêmica. Os frutos avaliados foram o morango (cv. Toianoca, Camarosa, Oso Grande e Camino Real), a amora-preta e a framboesa vermelha, em dois tempos de amostragem, sendo considerado como tempo A1 e tempo A2. As amostras foram caracterizadas quanto ao seu conteúdo de fenólicos totais, conteúdo de antocianinas monoméricas, capacidade antioxidan

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5

Al-kandari, Sharifa. "Purification, characterization, and hydrolytic activity of alpha-galactosidase from Lactobacillus helveticus ATCC 10797." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=97889.

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In this study, alpha-Galactosidase (alpha-D-galactoside-galactohydrolase, EC 3.2.1.22) has been isolated, purified, and characterized from intracellular fraction of Lactobacillus helveticus ATCC 10797. It was purified by a combination of ammonium sulfate precipitation and fast performance liquid chromatography system using ion exchange and gel-filtration columns. This enzyme was purified to only 9.44 fold over the crude extract with a recovery of 1.8%. The km of 3.83 mM and Vmax of 416.44 mumol/min/mg protein were calculated from PNPG. The molecular mass was estimated to be 188 kDa by gel-filt

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6

Schuff, Brandon Patrick. "Palladium (II)-catalyzed stereoselective formation of [alpha]-O-glycosides." Thesis, Montana State University, 2007. http://etd.lib.montana.edu/etd/2007/schuff/SchuffB0507.pdf.

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7

Arab-Jaziri, Faten. "Etudes structures/Fonctions et Ingénierie de l'alpha-L-arabinofuranosidase de Thermobacillus Xylanilyticus." Thesis, Toulouse, INSA, 2012. http://www.theses.fr/2012ISAT0053/document.

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Dans ce projet de thèse, une variété de techniques a été employée pour étudier l’alpha-L-arabinofuranosidase de Thermobacillus xylanilyticus (TxAbf), notamment en ce qui concerne les relations structure/fonctions et son activité de transglycosylation. Nos travaux ont eu pour objectif d’apporter un éclairage quant au rôle de la dynamique dans l’activité catalytique de la TxAbf, en se focalisant sur le mouvement de la boucle bêta2alpha2, et d’explorer la spécificité du sous-site [+1], un élément du site actif qui est particulièrement pertinent pour l’activité de transglycosylation. Enfin, nous a

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8

Osanjo, George Oyamo. "Évolution dirigée de l'alpha-L-fucosidase de Thermotoga maritima en alpha-L-transfucosidase et application à la synthèse regiosélective d'oligosaccharides." Nantes, 2008. http://www.theses.fr/2007NANT2132.

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Les glycanes, en particulier, les oligosaccharides fucosylés (FucOS), sont de plus en plus reconnus pour leurs rôles biologiques clés. Ces oligosaccharides sont impliqués dans les processus biomoléculaires tels que les communication intercellulaires, la régulation de la croissance, les processus inflammatoires, la différentiation cellulaire, la fertilisation, et les métastases de cancers. Chez l’homme, les déterminants du groupe sanguin d’ABO ainsi que ceux de Lewis sont des glycotopes fucosylés. Ces composés et leurs analogues suscitent désormais un grand intérêt scientifique vu leur potentie

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9

Chinnathambi, S. "Isolation, purification and characterization of alpha- arabinofuranosidase and other glycosidases from sclerotium rolfsii." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1997. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3289.

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10

McKay, Matthew Joseph. "Applications of cationic transition-metal-catalysis : the stereoselective synthesis of beta-O-aryl glycosides and alpha-urea glycosides." Diss., University of Iowa, 2014. https://ir.uiowa.edu/etd/4692.

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Having access to mild and operationally simple techniques for attaining carbohydrate targets will be necessary to facilitate advancement in biological, medicinal, and pharmacological research. Even with the abundance of elegant reports for generating glycosidic linkages, the stereoselective construction of alpha- and beta-oligosaccharides and glycoconjugates is by no means trivial. In an era when expanded awareness of the impact we are having on the environment drives the state-of-the-art, synthetic chemists are tasked with developing cleaner and more efficient reactions for achieving their tr

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11

Pastor, Patrick A. "A theoretical study of anomeric methyl glycosides separated by ion mobility spectrometry : the sodium adducts of alpha- and beta-methyl-D-mannopyranoside." Online access for everyone, 2007. http://www.dissertations.wsu.edu/Thesis/Summer2007/p_pastor_051807.pdf.

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12

Bennet, A. J. "A study of the complete kie description of the transition state for the specific acid catalysed hydrolosis of methyl alpha- and beta-glucopyranosides." Thesis, University of Bristol, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.354681.

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13

Dejob, Magali. "Études structurales et fonctionnelles d'alpha-glucosidases bactériennes." Thesis, Lyon 1, 2013. http://www.theses.fr/2013LYO10117/document.

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Il est reconnu, depuis des années, que la flore intestinale par son équilibre complexe et dynamique joue un rôle essentiel dans la santé humaine. Une des stratégies les plus prometteuses pour la maintenir ou l’améliorer consiste à moduler le microbiome par l’utilisation de bactéries probiotiques ou de sucres prébiotiques. C’est dans ce contexte que s’inscrivent les études structurales et fonctionnelles d’α glucosidases bactériennes développées dans cette thèse. Ces enzymes hydrolysant les liaisons α-(1,4) glucosidiques sont classées, selon la base de données CAZy, dans les familles de glycosid

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14

Dostanic, Ivan. "Defining the Physiological Role of the Na, K-ATPase Alpha 1 and Alpha 2 Isoforms in the Regulation of Cardiovascular Function." University of Cincinnati / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1100887954.

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15

Lu, Dan. "Synthèse d'oligosaccharides pour applications biologiques : aminoéthyle glycoside de sialyl Lewis X et glycosyl-carbasucres." Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066407.

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Les glucides, les biomolécules les plus abondants dans la nature, sont essentiels pour le maintien et la survie des organismes. Certaines molécules à base de glucides à la fois d'origine synthétique et naturelle sont connues pour leurs activités pharmacologiques et utilisés pour traiter différentes maladies. Deux projets ont été réalisés sur la base d'oligosaccharides biologiquement actifs dans cette thèse. Sialyl Lewis X (sLex), un tétrasaccharide exprimé sur la surface cellulaire d'un tissu embryonnaire et un tissu tumoral, a été découvert pour jouer un rôle important dans l'adhésion entre l

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16

Irague, Romain. "Ingénierie des glucane-saccharases de la famille 70 des glycoside-hydrolases pour la synthèse de nouveaux biopolymères." Thesis, Toulouse, INSA, 2011. http://www.theses.fr/2011ISAT0043/document.

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Les glucane-saccharases sont des transglucosidases de la famille 70 des glycoside-hydrolases. A partir de saccharose, ces enzymes catalysent la synthèse d’alpha -glucanes, polymères de haute masse molaire formés d’unités glucosyle. Elles sont aussi capables de synthétiser des oligosaccharides ou glucoconjugués par réaction de transglucosylation sur des accepteurs exogènes de natures variées. De par la diversité de leurs spécificités, tant au niveau des liaisons osidiques synthétisées [alpha (1→2) ; alpha (1→3) ; alpha (1→4) ou alpha (1→6)] que de l’organisation de ces liaisons au sein des prod

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17

Noël, Amandine. "Etude comparative de la réactivité des β-lactones et β-thiolactones. Synthèse stéréosélective d’α-C- et S-glycosides à partir de dérivés de l’acide N-acétylneuraminique". Thesis, Paris 11, 2012. http://www.theses.fr/2012PA112274/document.

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Les β-lactones étant présentes dans de nombreux composés naturels biologiquement actifs, cette famille de molécules a été intensivement étudiée aussi bien d’un point de vue structural que pour leur réactivité, contrairement aux β-thiolactones. Afin d’établir un parallèle entre ces deux familles, nous avons étudié leur stabilité thermique en comparant les vitesses d’extrusion de CO2 et COS. Le suivi réactionnel a été réalisé par UV-spectrométrie de masse sur des β-lactones di-, tri- et tétrasubstituées et les β-thiolactones correspondantes, dans deux solvants (un polaire, l’autre apolaire). Uti

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18

Noël, Amandine. "Etude comparative de la réactivité des β-lactones et β-thiolactones. Synthèse stéréosélective d'α-C- et S-glycosides à partir de dérivés de l'acide N-acétylneuraminique". Phd thesis, Université Paris Sud - Paris XI, 2012. http://tel.archives-ouvertes.fr/tel-00912334.

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Les β-lactones étant présentes dans de nombreux composés naturels biologiquement actifs, cette famille de molécules a été intensivement étudiée aussi bien d'un point de vue structural que pour leur réactivité, contrairement aux β-thiolactones. Afin d'établir un parallèle entre ces deux familles, nous avons étudié leur stabilité thermique en comparant les vitesses d'extrusion de CO2 et COS. Le suivi réactionnel a été réalisé par UV-spectrométrie de masse sur des β-lactones di-, tri- et tétrasubstituées et les β-thiolactones correspondantes, dans deux solvants (un polaire, l'autre apolaire). Uti

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19

Gustafsson, Tomas. "Asymmetric Synthesis of C-Glycosylated Amino Acids : Incorporation in Collagen Glycopeptides and Evaluation in a Model for Rheumatoid Arthritis." Doctoral thesis, Umeå : Univ, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-623.

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20

Goff, Randal Donald. "Structure-Activity Studies of Glycosphingolipids as Antigens of Natural Killer T Cells." BYU ScholarsArchive, 2006. https://scholarsarchive.byu.edu/etd/942.

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Glycosphingolipids (GSLs), composed of a polar saccharide head and a lipophilic ceramide tail, are ubiquitous components of the plasma membrane of eukaryotic cells. They serve in many regulatory capacities and have antigenic properties towards natural killer T (NKT) cells of the innate immune system. Critical to the recognition of glycosylceramides by NKT cells are antigen presenting cells (APC), such as dendritic cells, which are responsible for binding, processing, and delivery of ligands to these lymphocytes. This event is mediated by CD1d, a major histocompatibility complex-like protein ex

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21

Joly, Jean-Pierre. "Synthèse d'éthers-couronnes osidiques et leur fixation sur support chromatographique en vue de la séparation d'énantiomères." Nancy 1, 1989. http://www.theses.fr/1989NAN10019.

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Synthèse de divers 18-crowns-6 porteurs d'une partie ose condensée aptes à être fixes sur un support chromatographique ; greffage de silice pour HPLC ; synthèse de supports chromatographiques porteurs de motifs halogénure de benzyle et étude de leur fonctionnalisation par les composés crowns préparés ; complexation des éthers crowns par le potassium, le phenylglycinate d'éthyle, l'éthyl phényl ammonium ; séparation chromatographique de la phénylglycine

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22

"N-glycosidase activity of [alpha]- and [beta]-momorcharins." Chinese University of Hong Kong, 1994. http://library.cuhk.edu.hk/record=b5888168.

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Poon Yin-tat.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 1994.<br>Includes bibliographical references (leaves 101-111).<br>ACKNOWLEDGEMENTS --- p.I<br>ABSTRACT --- p.II<br>LIST OF ABBREVIATIONS --- p.IV<br>TABLE OF CONTENTS --- p.V<br>Chapter CHAPTER 1: --- INTRODUCTION --- p.1<br>Chapter CHAPTER 2: --- PURIFICATION OF α- AND β-MOMORCHARINS --- p.26<br>Chapter CHAPTER 3: --- N-GLYCOSIDASE ACTIVITY OF α- AND β-MOMORCHARINS --- p.45<br>REFERENCES --- p.101

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23

Lodge, Jacinta [Verfasser]. "The crystal structure of α-glucosidase [alpha-glucosidase] A, AglA, from Thermotoga maritima : the first structure of a family 4 glycosyl hydrolase defines a new glycosidase clan / von Jacinta Lodge". 2003. http://d-nb.info/97088219X/34.

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24

Numao, Shin. "Mechanisms of alpha-glycosidases." Thesis, 2003. http://hdl.handle.net/2429/16159.

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α-Retaining glycosidases are a class of hydrolytic enzymes that cleave α-glycosidic linkages with net retention of configuration at the anomeric center. The finer details of the mechanisms of two such enzymes, Golgi α-mannosidase II and human pancreatic α-amylase, were investigated in order to gain better understanding of this class of enzymes. α-Retaining mannosidases, like all other retaining glycosidases, employ a double displacement mechanism in which a transient glycosyl-enzyme intermediate is formed. In order to isolate or "trap" this key intermediate, two active site probes wer

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25

Khunsook, Sumpars. "Purification and characterization of human sperm plasma membrane-associated and human seminal fluid [alpha]-L-fucosidases /." Diss., 2001. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3036265.

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26

Chaudet, Marcia. "Comparative functional analysis of two alpha-glucosidases, Family 31 Glycoside Hydrolases from the human gut symbiont Bacteroides thetaiotaomicron." Thesis, 2012. http://hdl.handle.net/10012/6622.

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The human gut is home to a significant number of microorganisms including the dominant symbiont Bacteroides thetaiotaomicron. This microbe is predicted to possess an array of glycoside hydrolases, majority of which are involved in starch utilization. Presented here is a comparative functional analysis of two alpha-glucosidases, Family 31 Glycoside Hydrolases from Bacteroides thetaiotaomicron. Enzymatic kinetics revealed these enzymes both preferentially cleave alpha-(1,6) linkage in comparison to the predicted alpha-(1,4) and favour maltose derived substrates of longer length.

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27

Shah, Niket. "Elucidation of the Catalytic Mechanism of Golgi alpha-mannosidase II." Thesis, 2008. http://hdl.handle.net/1807/17280.

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The central dogma of molecular biology outlines the process of information transfer from a DNA sequence, to a protein chain. Beyond the step of protein synthesis, there are a variety of post-translational modiﬁcations that can take place, one of which is addition of carbohydrate chains to nascent proteins, known as glycosylation. The N-linked glycosylation pathway is responsible for the covalent attachment of multifunctional carbohydrate chains on asparagine residues of nascent proteins at Asn-X-Ser/Thr consensus sequences. These carbohydrate chains are thought to aid in cell signaling, immune

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28

Lee, An-Sheng, and 李安生. "Effect of alpha1-adrenoceptor antagonists and a new cardiac glycoside on heart." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/22356971904141483911.

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博士<br>國立臺灣大學<br>藥理學研究所<br>96<br>Hypertension is one of the most common cardiovascular diseases. It results in many complications such as coronary heart disease, stroke, hypertrophy, and heart failure. There are many classes of drugs used in the treatment of hypertension including alpha1-adrenoceptors antagonists. In the cardiovascular system, alpha1-adrenoceptors play important roles not only in the normal physiological regulation of vascular tone and blood pressure, but also in the pathogenesis of cardiac hypertrophy, heart failure, and arrhythmias. Alpha1- adrenoceptors antagonists such as p

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29

Sim, Lyann. "Structural and Inhibition Studies of Human Intestinal Glucosidases." Thesis, 2010. http://hdl.handle.net/1807/24878.

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Human maltase-glucoamylase (MGAM) and sucrase-isomaltase (SI) are the small-intestinal glucosidases responsible for catalyzing the last glucose-releasing step in starch digestion. MGAM and SI are each composed of duplicated catalytic domains, N- and C-terminal, which display complementary substrate specificities for the mixture of short linear and branch oligosaccharide substrates that typically make up terminal starch digestion products. As MGAM and SI are involved in post-prandial glucose production, regulating their activities with α-glucosidase inhibitors is an attractive approach to contr

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