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Journal articles on the topic 'Alpha-secretases'

Author: Grafiati
Published: 25 May 2024
Last updated: 31 July 2025

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1

Nunan, Janelle, and David H. Small. "Proteolytic processing of the amyloid-beta protein precursor of Alzheimer's disease." Essays in Biochemistry 38 (October 1, 2002): 37–49. http://dx.doi.org/10.1042/bse0380037.

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The proteolytic processing of the amyloid-beta protein precursor plays a key role in the development of Alzheimer's disease. Cleavage of the amyloid-beta protein precursor may occur via two pathways, both of which involve the action of proteases called secretases. One pathway, involving beta- and gamma-secretase, liberates amyloid-beta protein, a protein associated with the neurodegeneration seen in Alzheimer's disease. The alternative pathway, involving alpha-secretase, precludes amyloid-beta protein formation. In this review, we describe the progress that has been made in identifying the sec
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2

Luca, Monica Di. "Alpha beta-and gamma-secretases in alzheimer s disease." Frontiers in Bioscience S4, no. 3 (2012): 1126–50. http://dx.doi.org/10.2741/s322.

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3

Mezyk, Renata, Monika Bzowska, and Joanna Bereta. "Structure and functions of tumor necrosis factor-alpha converting enzyme." Acta Biochimica Polonica 50, no. 3 (2003): 625–45. http://dx.doi.org/10.18388/abp.2003_3656.

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Tumor necrosis factor-alpha converting enzyme (TACE) is the first described and best characterized secretase. In this review the structure and the possible roles for TACE are summarized. The substrate specificity and the regulation of TACE activity as well as redundancy and possible cooperations of distinct secretases are also discussed.
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4

Saha, Nayanendu, Eric Chan, Rachelle P. Mendoza, Yevgeniy Romin, Murray J. Tipping, and Dimitar B. Nikolov. "Antibodies targeting ADAM17 reverse neurite outgrowth inhibition by myelin-associated inhibitors." Life Science Alliance 8, no. 6 (2025): e202403126. https://doi.org/10.26508/lsa.202403126.

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Upon spinal cord injury, axons attempting to regenerate need to overcome the repulsive actions of myelin-associated inhibitors, including the myelin-associated glycoprotein, Nogo-A, and the oligodendrocyte myelin glycoprotein. These inhibitors bind and signal through a neuronal receptor/co-receptor/transducer complex composed of NgR1, Lingo-1, and p75. Consequently, p75 is cleaved by alpha secretase followed by gamma-secretase, triggering downstream signaling that inhibits axonal regrowth. ADAM10 and ADAM17 are both known to function as alpha secretases in neurons. Here we show that ADAM17, an
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5

Kiesel, Violet A., and Silvia D. Stan. "Diallyl trisulfide, a chemopreventive agent from Allium vegetables, inhibits alpha-secretases in breast cancer cells." Biochemical and Biophysical Research Communications 484, no. 4 (2017): 833–38. http://dx.doi.org/10.1016/j.bbrc.2017.01.184.

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6

Singh, Som, Felix Yang, Andy Sivils, Victoria Cegielski, and Xiang-Ping Chu. "Amylin and Secretases in the Pathology and Treatment of Alzheimer’s Disease." Biomolecules 12, no. 7 (2022): 996. http://dx.doi.org/10.3390/biom12070996.

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Alzheimer’s disease remains a prevailing neurodegenerative condition which has an array physical, emotional, and financial consequences to patients and society. In the past decade, there has been a greater degree of investigation on therapeutic small peptides. This group of biomolecules have a profile of fundamentally sound characteristics which make them an intriguing area for drug development. Among these biomolecules, there are four modulatory mechanisms of interest in this review: alpha-, beta-, gamma-secretases, and amylin. These protease-based biomolecules all have a contributory role in
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7

Manav, Kumar 1. Alok Kumar1 Kajal Kumari1 Priyanka Kumari1 Shweta Kumari1 Divya Roshni Panna1 Suman Kumari1 Bina Kumari1 Sapna Kumari1 Anuradha Kumari1 Asfaque Ali1 Najibullah Mujahid 1. Laxman Kumar Mahto1 Maheshwar Kumar1 Saurav Kumar1 Ved Prakash Singh1 Soyab Akhtar1 Arnab Roy2*. "A Detailed Analysis Of Alzheimer's Disease Pathophysiology: The Influence Of Oxidative Stress On Amyloid Precursor Protein Metabolism And Secretase Activity." International Journal in Pharmaceutical Sciences 2, no. 9 (2024): 439–57. https://doi.org/10.5281/zenodo.13732112.

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Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by cognitive decline, memory impairment, and distinct neuropathological features such as amyloid-beta (Aβ) plaques and neurofibrillary tangles. Despite extensive research, the molecular mechanisms underlying AD remain incompletely understood, posing challenges for therapeutic intervention. This review delves into the intricate processes of amyloid precursor protein (APP) processing, focusing on the roles of α-, β-, and γ-secretases in the generation of neurotoxic Aβ peptides. We explore th
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8

Assaf, Naglaa, Marwa E. El-Shamarka, Neveen A. Salem, Yasser A. Khadrawy, and Nesrine S. El Sayed. "Neuroprotective effect of PPAR alpha and gamma agonists in a mouse model of amyloidogenesis through modulation of the Wnt/beta catenin pathway via targeting alpha- and beta-secretases." Progress in Neuro-Psychopharmacology and Biological Psychiatry 97 (March 2020): 109793. http://dx.doi.org/10.1016/j.pnpbp.2019.109793.

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9

Kim, Doo Yeon, Laura A. MacKenzie Ingano, Bryce W. Carey, Warren Pettingell, and Dora M. Kovacs. "P4-290 Voltage-gated sodium channel beta2 subunit is processed by alpha-, beta- and gamma-secretases, generating fragments elevated in AD brains." Neurobiology of Aging 25 (July 2004): S557—S558. http://dx.doi.org/10.1016/s0197-4580(04)81848-7.

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10

Kron, Nicholas S., and Lynne A. Fieber. "Aplysia Neurons as a Model of Alzheimer’s Disease: Shared Genes and Differential Expression." Journal of Molecular Neuroscience 72, no. 2 (2021): 287–302. http://dx.doi.org/10.1007/s12031-021-01918-3.

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AbstractAlthough Alzheimer’s disease (AD) is the most common form of dementia in the United States, development of therapeutics has proven difficult. Invertebrate alternatives to current mammalian AD models have been successfully employed to study the etiology of the molecular hallmarks of AD. The marine snail Aplysia californica offers a unique and underutilized system in which to study the physiological, behavioral, and molecular impacts of AD. Mapping of the Aplysia proteome to humans and cross-referencing with two databases of genes of interest in AD research identified 898 potential ortho
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11

Lopez Lloreda, Claudia, Sarah Chowdhury, Shivesh Ghura, Elena Alvarez-Periel, and Kelly Jordan-Sciutto. "HIV-Associated Insults Modulate ADAM10 and Its Regulator Sirtuin1 in an NMDA Receptor-Dependent Manner." Cells 11, no. 19 (2022): 2962. http://dx.doi.org/10.3390/cells11192962.

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Neurologic deficits associated with human immunodeficiency virus (HIV) infection impact about 50% of persons with HIV (PWH). These disorders, termed HIV-associated neurocognitive disorders (HAND), possess neuropathologic similarities to Alzheimer’s disease (AD), including intra- and extracellular amyloid-beta (Aβ) peptide aggregates. Aβ peptide is produced through cleavage of the amyloid precursor protein (APP) by the beta secretase BACE1. However, this is precluded by cleavage of APP by the non-amyloidogenic alpha secretase, ADAM10. Previous studies have found that BACE1 expression was increa
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12

Yanagino, Kaori, and Naoyuki Miyashita. "Structure Prediction of the Transmembrane Region of Alpha- and Beta- Secretases using Replica-Exchange Molecular Dynamics Simulations, and the Interaction between Amyloid Precursor Protein and Them." Biophysical Journal 120, no. 3 (2021): 25a. http://dx.doi.org/10.1016/j.bpj.2020.11.414.

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13

Sharifulina, Svetlana, Andrey Khaitin, Valeria Guzenko, et al. "Expression of Amyloid Precursor Protein, Caveolin-1, Alpha-, Beta-, and Gamma-Secretases in Penumbra Cells after Photothrombotic Stroke and Evaluation of Neuroprotective Effect of Secretase and Caveolin-1 Inhibitors." Biomedicines 10, no. 10 (2022): 2655. http://dx.doi.org/10.3390/biomedicines10102655.

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Our studies reveal changes in the expression of the main participants in the processing of amyloid precursor protein (APP) in neurons and astrocytes after photothrombotic stroke (PTS). Here we show the increase in the level of N- and C-terminal fragments of APP in the cytoplasm of ischemic penumbra cells at 24 h after PTS and their co-immunoprecipitation with caveolin-1. The ADAM10 α-secretase level decreased in the rat brain cortex on the first day after PTS. Levels of γ-secretase complex proteins presenilin-1 and nicastrin were increased in astrocytes, but not in neurons, in the penumbra aft
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14

Stan, Silvia, and Minna Abtahi. "Mechanisms of Action of Diallyl Trisulfide in Breast Ductal Carcinoma In Situ Cells." Current Developments in Nutrition 4, Supplement_2 (2020): 353. http://dx.doi.org/10.1093/cdn/nzaa044_052.

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Abstract Objectives Breast ductal carcinoma in situ (DCIS) is an early stage, localized form of breast cancer that can progress to an invasive breast cancer phenotype. Diallyl trisulfide is a bioactive organosulfur compound derived from Allium vegetables that has been shown to have anticancer effects in various cancer models. We have previously shown that diallyl trisulfide inhibits alpha secretases and Notch signaling pathway components in breast cancer cells. The objective of this study was to investigate the mechanisms of action of diallyl trisulfide in breast DCIS cells, with a primary foc
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15

Buniatian, Gayane Hrachia, Ute Schwinghammer, Roman Tremmel та ін. "Consequences of Amyloid‐β Deficiency for the Liver". Advanced Science, 2 березня 2024. http://dx.doi.org/10.1002/advs.202307734.

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AbstractThe hepatic content of amyloid beta (Aβ) decreases drastically in human and rodent cirrhosis highlighting the importance of understanding the consequences of Aβ deficiency in the liver. This is especially relevant in view of recent advances in anti‐Aβ therapies for Alzheimer's disease (AD). Here, it is shown that partial hepatic loss of Aβ in transgenic AD mice immunized with Aβ antibody 3D6 and its absence in amyloid precursor protein (APP) knockout mice (APP‐KO), as well as in human liver spheroids with APP knockdown upregulates classical hallmarks of fibrosis, smooth muscle alpha‐ac
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16

Halawany, Ali M. El, Nesrine S. EL Sayed, Hossam M. Abdallah та Riham Salah El Dine. "Protective effects of gingerol on streptozotocin-induced sporadic Alzheimer’s disease: emphasis on inhibition of β-amyloid, COX-2, alpha-, beta - secretases and APH1a". Scientific Reports 7, № 1 (2017). http://dx.doi.org/10.1038/s41598-017-02961-0.

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17

El Halawany, Ali M., Nesrine S. EL Sayed, Hossam M. Abdallah та Riham Salah El Dine. "Retraction Note: Protective effects of gingerol on streptozotocin-induced sporadic Alzheimer’s disease: emphasis on inhibition of β-amyloid, COX-2, alpha-, beta - secretases and APH1a". Scientific Reports 13, № 1 (2023). http://dx.doi.org/10.1038/s41598-023-36652-w.

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