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Relevant bibliographies by topics / Alphavirus

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Academic literature on the topic 'Alphavirus'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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Journal articles on the topic "Alphavirus"

1

Mostafavi, Helen, Eranga Abeyratne, Ali Zaid, and Adam Taylor. "Arthritogenic Alphavirus-Induced Immunopathology and Targeting Host Inflammation as A Therapeutic Strategy for Alphaviral Disease." Viruses 11, no. 3 (2019): 290. http://dx.doi.org/10.3390/v11030290.

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Arthritogenic alphaviruses are a group of medically important arboviruses that cause inflammatory musculoskeletal disease in humans with debilitating symptoms, such as arthralgia, arthritis, and myalgia. The arthritogenic, or Old World, alphaviruses are capable of causing explosive outbreaks, with some viruses of major global concern. At present, there are no specific therapeutics or commercially available vaccines available to prevent alphaviral disease. Infected patients are typically treated with analgesics and non-steroidal anti-inflammatory drugs to provide often inadequate symptomatic re

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Landers, V. Douglas, Daniel W. Wilkey, Michael L. Merchant, Thomas C. Mitchell, and Kevin J. Sokoloski. "The Alphaviral Capsid Protein Inhibits IRAK1-Dependent TLR Signaling." Viruses 13, no. 3 (2021): 377. http://dx.doi.org/10.3390/v13030377.

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Alphaviruses are arthropod-borne RNA viruses which can cause either mild to severe febrile arthritis which may persist for months, or encephalitis which can lead to death or lifelong cognitive impairments. The non-assembly molecular role(s), functions, and protein–protein interactions of the alphavirus capsid proteins have been largely overlooked. Here we detail the use of a BioID2 biotin ligase system to identify the protein–protein interactions of the Sindbis virus capsid protein. These efforts led to the discovery of a series of novel host–pathogen interactions, including the identification

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Kaelber, Jason T., David Chmielewski, Wah Chiu, and Albert J. Auguste. "Alphavirus Particles Can Assemble with an Alternate Triangulation Number." Viruses 14, no. 12 (2022): 2650. http://dx.doi.org/10.3390/v14122650.

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Alphaviruses are spherical, enveloped RNA viruses primarily transmitted by mosquitoes, and cause significant arthritogenic and neurotropic disease in humans and livestock. Previous reports have shown that—in contrast to prototypical icosahedral viruses—alphaviruses incorporate frequent defects, and these may serve important functions in the viral life cycle. We confirm the genus-wide pleomorphism in live viral particles and extend our understanding of alphavirus assembly through the discovery of an alternate architecture of Eastern equine encephalitis virus (EEEV) particles. The alternate T =

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Bedoui, Yosra, Dauriane De Larichaudy, Matthieu Daniel, et al. "Deciphering the Role of Schwann Cells in Inflammatory Peripheral Neuropathies Post Alphavirus Infection." Cells 12, no. 1 (2022): 100. http://dx.doi.org/10.3390/cells12010100.

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Old world alphaviruses (e.g., chikungunya) are known to cause severe acute and chronic debilitating arthralgia/arthritis. However, atypical neurological manifestations and, in particular, unexpected cases of acute inflammatory Guillain–Barre syndrome (GBS) have been associated with the arthritogenic alphaviruses. The pathogenesis of alphavirus-associated GBS remains unclear. We herein addressed for the first time the role of Schwann cells (SC) in peripheral neuropathy post-alphaviral infection using the prototypical ONNV alphavirus model. We demonstrated that human SC expressed the recently id

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Cherkashchenko, Liubov, Kai Rausalu, Sanjay Basu, Luke Alphey, and Andres Merits. "Expression of Alphavirus Nonstructural Protein 2 (nsP2) in Mosquito Cells Inhibits Viral RNA Replication in Both a Protease Activity-Dependent and -Independent Manner." Viruses 14, no. 6 (2022): 1327. http://dx.doi.org/10.3390/v14061327.

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Alphaviruses are positive-strand RNA viruses, mostly being mosquito-transmitted. Cells infected by an alphavirus become resistant to superinfection due to a block that occurs at the level of RNA replication. Alphavirus replication proteins, called nsP1-4, are produced from nonstructural polyprotein precursors, processed by the protease activity of nsP2. Trans-replicase systems and replicon vectors were used to study effects of nsP2 of chikungunya virus and Sindbis virus on alphavirus RNA replication in mosquito cells. Co-expressed wild-type nsP2 reduced RNA replicase activity of homologous vir

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Souza-Souza, Kauê F. C., Cassiano F. Gonçalves-de-Albuquerque, Cláudio Cirne-Santos, Izabel C. N. P. Paixão, and Patrícia Burth. "Alphavirus Replication: The Role of Cardiac Glycosides and Ion Concentration in Host Cells." BioMed Research International 2020 (May 9, 2020): 1–7. http://dx.doi.org/10.1155/2020/2813253.

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Alphaviruses are arthropod-borne viruses that can cause fever, rash, arthralgias, and encephalitis. The mosquito species Aedes aegypti and Aedes albopictus are the most frequent transmitters of alphaviruses. There are no effective vaccines or specific antivirals available for the treatment of alphavirus-related infections. Interestingly, changes in ion concentration in host cells have been characterized as critical regulators of the alphavirus life cycle, including fusion with the host cell, glycoprotein trafficking, genome translation, and viral budding. Cardiac glycosides, which are classica

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Powers, Ann M., Aaron C. Brault, Yukio Shirako, et al. "Evolutionary Relationships and Systematics of the Alphaviruses." Journal of Virology 75, no. 21 (2001): 10118–31. http://dx.doi.org/10.1128/jvi.75.21.10118-10131.2001.

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ABSTRACT Partial E1 envelope glycoprotein gene sequences and complete structural polyprotein sequences were used to compare divergence and construct phylogenetic trees for the genus Alphavirus. Tree topologies indicated that the mosquito-borne alphaviruses could have arisen in either the Old or the New World, with at least two transoceanic introductions to account for their current distribution. The time frame for alphavirus diversification could not be estimated because maximum-likelihood analyses indicated that the nucleotide substitution rate varies considerably across sites within the geno

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Lundstrom, Kenneth. "Alphaviruses in Immunotherapy and Anticancer Therapy." Biomedicines 10, no. 9 (2022): 2263. http://dx.doi.org/10.3390/biomedicines10092263.

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Alphaviruses have been engineered as expression vectors for vaccine development and gene therapy. Due to the feature of RNA self-replication, alphaviruses can provide exceptional direct cytoplasmic expression of transgenes based on the delivery of recombinant particles, naked or nanoparticle-encapsulated RNA or plasmid-based DNA replicons. Alphavirus vectors have been utilized for the expression of various antigens targeting different types of cancers, and cytotoxic and antitumor genes. The most common alphavirus vectors are based on the Semliki Forest virus, Sindbis virus and Venezuelan equin

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Rao, Shambhavi, and Adam Taylor. "Arthritogenic Alphavirus Capsid Protein." Life 11, no. 3 (2021): 230. http://dx.doi.org/10.3390/life11030230.

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In the past two decades Old World and arthritogenic alphavirus have been responsible for epidemics of polyarthritis, causing high morbidity and becoming a major public health concern. The multifunctional arthritogenic alphavirus capsid protein is crucial for viral infection. Capsid protein has roles in genome encapsulation, budding and virion assembly. Its role in multiple infection processes makes capsid protein an attractive target to exploit in combating alphaviral infection. In this review, we summarize the function of arthritogenic alphavirus capsid protein, and describe studies that have

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Xie, Yifan, Jie Cao, Shuyi Gan, et al. "TRIM32 inhibits Venezuelan equine encephalitis virus infection by targeting a late step in viral entry." PLOS Pathogens 20, no. 11 (2024): e1012312. http://dx.doi.org/10.1371/journal.ppat.1012312.

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Alphaviruses are mosquito borne RNA viruses that are a reemerging public health threat. Alphaviruses have a broad host range, and can cause diverse disease outcomes like arthritis, and encephalitis. The host ubiquitin proteasome system (UPS) plays critical roles in regulating cellular processes to control the infections with various viruses, including alphaviruses. Previous studies suggest alphaviruses hijack UPS for virus infection, but the molecular mechanisms remain poorly characterized. In addition, whether certain E3 ubiquitin ligases or deubiquitinases act as alphavirus restriction facto

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Dissertations / Theses on the topic "Alphavirus"

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Berglund, Peter. "Alphavirus vectors as recombinant vaccines /." Stockholm, 1997. http://diss.kib.ki.se/1997/91-628-2657-3.

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Skoging, Nyberg Ulrica. "Protein interactions involved in alphavirus assembly /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4329-x/.

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Shabman, Reed Solomon Heise Mark T. "Alphavirus evasion of type I interferons." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,1879.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2008.<br>Title from electronic title page (viewed Dec. 11, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Microbiology and Immunology." Discipline: Microbiology and Immunology; Department/School: Medicine.

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Lim, Elisa X. "Host-pathogen interactions during alphavirus infection." Thesis, Griffith University, 2021. http://hdl.handle.net/10072/410163.

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Arthritogenic alphavirus infection causes debilitating pain in the joints and muscles with many patients experiencing such symptoms chronically. However, there is insufficient evidence to explain the underlying causes behind symptoms of persistent arthralgia and myalgia. Joint-associated tissues are the main site of inflammation during alphavirus infection, and it has been shown that alphaviruses induce damage to the cartilage and synovium. Therefore, the cell types present in these tissues play critical roles in disease pathogenesis. The findings described in this thesis contribute to the gen

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Li, Ke-Jun. "Semliki forest virus-derived packaging system for production of retroviral vectors /." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-3268-9/.

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Gershy-Damet, Guy-Michel. "Etude épidémiologue et virologique des infections à arbovirus en Côte d'Ivoire : aspects ultrastructuraux de l'infection expérimentale du nourrisson par la souche vaccinale antiamarile." Aix-Marseille 2, 1985. http://www.theses.fr/1985AIX21901.

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Nubgan, Amer S. "The role of the deubiquitylase MYSM1 during alphavirus infection." Thesis, University of Liverpool, 2017. http://livrepository.liverpool.ac.uk/3015357/.

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The members of the genus Alphavirus are positive-sense RNA viruses and it is one of two within the family Togaviridae. Most alphaviruses are predominantly transmitted to susceptible vertebrates by a mosquito vector. Alphavirus disease in humans can be severely debilitating, and depending on the particular viral species, infection may result in encephalitis and possibly life threatening symptoms. Chikungunya virus (CHIKV) is the aetiological agent represents a substantial health burden to affected populations, with clinical symptoms that include severe joint and muscle pain, rashes, and fever,

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Plaskon, Nicole Elyse. "The Development of New Tools to Investigate Alphavirus Replication Kinetics." Thesis, Virginia Tech, 2009. http://hdl.handle.net/10919/34787.

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<p>Members of the alphavirus genus pose a serious or potential threat to public health in many areas of the world. Nearly all alphaviruses are maintained in nature by transmission cycles that involve alternating replication in a susceptible vertebrate and invertebrate host. The maintenance of this transmission cycle depends on the establishment of a life-long persistent infection in the invertebrate vector host. Although alphavirus replication has been extensively studied in vertebrate models, the strand-specific replication kinetics of alphaviruses during persistent infections of the inverteb

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Belarbi, Essia. "Etude de la physiopathologie des infections à alphavirus arthritogènes par une approche d’imagerie in vivo." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS073.

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Les alphavirus arthritogènes de la rivière Ross (RRV) et du chikungunya (CHIKV) sont des arbovirus à l’origine de maladies inflammatoires musculosquelettiques chez l'homme. Ils sont largement distribués dans le monde et provoquent périodiquement des épidémies explosives. Les principaux signes cliniques lors d’une infection par un alphavirus arthritogène sont les myalgies, polyarthrites et arthralgies intenses pouvant persister plusieurs mois après l'infection. Les mécanismes de développement de l’infection et des manifestations persistantes sont peu connus. Pour étudier la pathogenèse de l'inf

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Castro, Ceyla Maria Oeiras de. "Análise metabolômica de alterações induzidas pelo vírus mayaro em células vero." Faculdade de Medicina de São José do Rio Preto, 2015. http://hdl.handle.net/tede/373.

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Submitted by Fabíola Silva (fabiola.silva@famerp.br) on 2017-08-03T11:44:01Z No. of bitstreams: 1 ceylamariaodecastro_tese.pdf: 1353174 bytes, checksum: 1308d049511e8f07c8b5a5d1f5aa3df6 (MD5)<br>Made available in DSpace on 2017-08-03T11:44:01Z (GMT). No. of bitstreams: 1 ceylamariaodecastro_tese.pdf: 1353174 bytes, checksum: 1308d049511e8f07c8b5a5d1f5aa3df6 (MD5) Previous issue date: 2015-09-03<br>This study aimed at assessing the extracellular metabolic profile of Vero cells infected by Mayaro virus. In this metabolomic study, the use of nuclear magnetic resonance associated to multivariat

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Books on the topic "Alphavirus"

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Blum, Birgitta Barbara Elisabeth. Genusspezifischer Nachweis von Alphaviren mit Hilfe kreuzreagierender monoklonaler Antikörper gegen konservierte Epitope. [s.n.], 1992.

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Tavani, Romolo, and Peter Georgas-Frey. Alphavirus. Independently Published, 2020.

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DiCiommo, David P. A novel, DNA-based alphavirus gene expression system for rapid recombinant protein purification and virus-based gene delivery to retina and retinoblastoma tumor cells. 2002.

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Alphaviruses: Current Biology. Caister Academic Press, 2016. http://dx.doi.org/10.21775/9781910190159.

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Depa, Larisse, Larissa Depa, Crhisllane Vasconcelos, Vagner Fonseca, and Diego Frias. Estudo do uso de códons nos vírus da Dengue, Zika e Chikungunya com foco em terapia por inibição seletiva de tRNAs contra arboviroses. Edited by Diego Mariano. Alfahelix, 2021. http://dx.doi.org/10.51780/978-6-5992753-3-3.

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O vírus da dengue (DENV), o vírus da Zika (ZIKV) e o vírus da chikungunya (CHIKV) são espécies que apresentam relevância clínica para a saúde pública. Porém, ainda não existe um tratamento específico ou vacina disponível para esses arbovírus. Nesse contexto, é fundamental encontrar novos alvos terapêuticos que possam auxiliar estratégias e tratamentos mais eficientes. A metodologia de codon usage tem demonstrado bons resultados para encontrar alvos para terapias que visam inibidores de tradução. Este estudo buscou analisar o uso de códons e o equilíbrio entre a abundância relativa dos RNAs tra

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DELphi- a cDNA library screening technology for mammalian cells based on an alphaviral expression system. 2000.

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Book chapters on the topic "Alphavirus"

1

Stollar, Victor. "Alphavirus‡." In The Springer Index of Viruses. Springer New York, 2011. http://dx.doi.org/10.1007/978-0-387-95919-1_304.

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Harrison, Stephen C. "Alphavirus Structure." In The Togaviridae and Flaviviridae. Springer New York, 1986. http://dx.doi.org/10.1007/978-1-4757-0785-4_2.

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Lundstrom, Kenneth. "Alphavirus-Based Vaccines." In Viral Vectors in Veterinary Vaccine Development. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-51927-8_11.

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Garoff, Henrik, and Kejun Li. "Alphavirus-Retrovirus Vectors." In Gene Therapy. Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-72160-1_6.

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Lundstrom, Kenneth. "Alphavirus-Based Vaccines." In Vaccine Design. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3389-1_22.

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Lundstrom, Kenneth. "Alphavirus-Based Vectors." In Neuromethods. Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-610-8_5.

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Lundstrom, Kenneth. "Alphavirus-Based Vaccines." In Methods in Molecular Biology. Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-6869-5_13.

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Griffin, Diane E. "Alphavirus Pathogenesis and Immunity." In The Togaviridae and Flaviviridae. Springer New York, 1986. http://dx.doi.org/10.1007/978-1-4757-0785-4_8.

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Rice, Charles M. "Alphavirus-Based Expression Systems." In Advances in Experimental Medicine and Biology. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4899-1382-1_5.

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Shafferman, A., S. Lustig, Y. Inbar, et al. "Alphavirus Hybrid Virion Vaccines." In Advances in Experimental Medicine and Biology. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4899-1382-1_6.

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Conference papers on the topic "Alphavirus"

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Cao, Yanran, Stene Anne, Lars Christian Gansel, Stig Atle Tuene, Grete Hansen Aas, and Anne Synnove Rosvik. "Natural infection induced immune response against salmonid alphavirus in farmed salmon." In OCEANS 2017 - Aberdeen. IEEE, 2017. http://dx.doi.org/10.1109/oceanse.2017.8084664.

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Santos, Franciellen Machado dos, VIVIANE HORN DE MELO, AMANDA PELLENZ RUIVO, FERNANDA M. S. GODINHO, and RICHARD STEINER SALVATO. "DETECÇÃO MOLECULAR DE ALPHAVIRUS E FLAVIVIRUS EM PACIENTES DO RIO GRANDE DO SUL." In IV Congresso Nacional de Microbiologia Clínica On-line. Revista Multidisciplinar em Saúde, 2024. http://dx.doi.org/10.51161/conamic2024/30268.

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CONT, R. N., and G. B. CABRAL. "DIAGNÓSTICO SOROLÓGICO DE CHIKUNGUNYA EM REGIÕES DE CO-CIRCULAÇÃO DE ARBOVIROSES." In III Mostra Dos Trabalhos De Conclusão De Curso Da Especialização Em Vigilância Laboratorial Em Saúde Pública. Agron Science, 2022. http://dx.doi.org/10.53934/10105-2.

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A febre Chikungunya, é a doença causada pela infecção do vírus Chikungunya, um alphavirus, da família Togaviridae, transmitida por mosquitos Aedes aegypti e Aedes albopictus, que circula no Brasil desde 2014. No ano vigente, até setembro, ocorreram 87.748 casos prováveis, e 10 óbitos confirmados por critérios laboratoriais. A co-circulação de arboviroses, como Dengue e Zika, é uma realidade em muitas regiões, o que dificulta o diagnóstico clínico, devido a semelhança dos sintomas entre essas doenças. Para um diagnóstico mais específico, utiliza-se os testes laboratoriais. Entretanto, um dos de

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Alipanah, Morteza, John A. Lednicky, J. Glenn Morris, and Z. Hugh Fan. "A Point-Of-Care Device Integrating Sample Preparation With Isothermal Amplification for Detection of Mayaro Virus." In ASME 2023 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2023. http://dx.doi.org/10.1115/imece2023-114292.

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Abstract Mayaro virus (MAYV) is an emerging mosquito-borne alphavirus that causes clinical symptoms similar to those caused by Chikungunya virus (CHIKV), Dengue virus (DENV), and Zika virus (ZIKV). To differentiate MAYV from these viruses diagnostically, we have developed the first reverse-transcription loop-mediated isothermal amplification (RT-LAMP) assay for detection of MAYV. We designed six LAMP primers targeting MAYV’s non-structural protein (NS1) gene and determined the visual limit of detection of at least 10 viral genome equivalents (GEs) per reaction. The assay was specific for MAYV,

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Rocha, Vinicius, Breno Barreto, Larissa Fonseca, et al. "An alphavirus-derived replicon polyvalent RNA vaccine induces neutralizing antibodies in mice against omicron SARS-CoV-2 variant of concern." In International Symposium on Immunobiologicals. Instituto de Tecnologia em Imunobiológicos, 2023. http://dx.doi.org/10.35259/isi.2023_57936.

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Silva, Victor Luiz Luciano da, URSULA RAIANNY LACERDA DA SILVA, AMANDA MARIA SANTANA DA COSTA, ITALO MATHEUS DA SILVA PEQUENO, and FRANCISCO ISRAEL MAGALHÃES FEIJAO. "CHIKUNGUNYA NO BRASIL: UM ESTUDO OBSERVACIONAL TRANSVERSAL COMPARANDO AS 16 PRIMEIRAS SEMANAS EPIDEMIOLÓGICAS DE 2021 E 2022." In I Congresso Brasileiro de Estudos Epidemiológicos On-line. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/epidemion/7622.

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Introdução: A chikungunya é uma arbovirose que consiste em uma doença febril, ocasionada pelo vírus de RNA chikungunya (CHIKV), do gênero Alphavirus cuja transmissão ocorre, principalmente, através da picada de fêmeas dos mosquitos Aedes aegypti e Aedes albopictus infectados. Objetivo: O objetivo do estudo é analisar as estatísticas da doença no Brasil, no período correspondente às 16 primeiras semanas epidemiológicas de 2021 e 2022, a fim de entender o cenário epidemiológico em sua totalidade. Material e Métodos: Realizou-se um estudo descritivo a partir de dados extraídos de Boletins Epidemi

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Silva, Victor Luiz Luciano da, URSULA RAIANNY LACERDA DA SILVA, AMANDA MARIA SANTANA DA COSTA, ITALO MATHEUS DA SILVA PEQUENO, and FRANCISCO ISRAEL MAGALHÃES FEIJAO. "CHIKUNGUNYA NO BRASIL: UM ESTUDO OBSERVACIONAL TRANSVERSAL COMPARANDO AS 16 PRIMEIRAS SEMANAS EPIDEMIOLÓGICAS DE 2021 E 2022." In I Congresso Brasileiro de Estudos Epidemiológicos On-line. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/epidemion/7622.

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Introdução: A chikungunya é uma arbovirose que consiste em uma doença febril, ocasionada pelo vírus de RNA chikungunya (CHIKV), do gênero Alphavirus cuja transmissão ocorre, principalmente, através da picada de fêmeas dos mosquitos Aedes aegypti e Aedes albopictus infectados. Objetivo: O objetivo do estudo é analisar as estatísticas da doença no Brasil, no período correspondente às 16 primeiras semanas epidemiológicas de 2021 e 2022, a fim de entender o cenário epidemiológico em sua totalidade. Material e Métodos: Realizou-se um estudo descritivo a partir de dados extraídos de Boletins Epidemi

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Ryabov, Vladimir, Peter Pushko, Irina Tretyakova, Rikka Saito, Richard B. Alexander, and Elena N. Klyushnenkova. "Abstract 2880: Novel alphavirus-based vaccine targets dendritic cells and efficiently breaks immunological tolerance to “self” tumor-associated antigen (PSA) in an HLA-DR mouse model of prostate cancer." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-2880.

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Abraham, Rachy, Aravinth Jayabalan, Robert L. McPherson, Anthony K. L. Leung, and Diane E. Griffin. "UNDERSTANDING OF “X DOMAIN” FUNCTION IN ALPHAVIRUSES." In Viruses: Discovering Big in Small. TORUS PRESS, 2019. http://dx.doi.org/10.30826/viruses-2019-04.

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Crosby, EJ, WR Gwin, S. Chang, et al. "Abstract P2-09-16: CD8 T cells induced by novel alphaviral vector predict improved progression free survival in advanced HER2+ breast cancer patients." In Abstracts: 2018 San Antonio Breast Cancer Symposium; December 4-8, 2018; San Antonio, Texas. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-p2-09-16.

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Reports on the topic "Alphavirus"

1

Strauss, James. Molecular Studies of Alphavirus Immunogenicity. Defense Technical Information Center, 1992. http://dx.doi.org/10.21236/ada264058.

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Austin, Riley. Modifications of Alphavirus Replicon Vaccine Platforms: A Literature Review. Iowa State University, 2023. http://dx.doi.org/10.31274/cc-20240624-1018.

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Loy, J. Dustin, Mark Mogler, Jill Gander, Kurt I. Kamrud, and D. L. Hank Harris. Development of an Alphavirus Replicon Classical Swine Fever Virus Vaccine Candidate. Iowa State University, 2013. http://dx.doi.org/10.31274/ans_air-180814-1256.

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Chen, Qi, Ryan Vander Veen, Darin M. Madson, and D. L. Hank Harris. Immunization for Influenza A Virus by Intranasal Administration of Alphavirus Replicon Particles. Iowa State University, 2013. http://dx.doi.org/10.31274/ans_air-180814-29.

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Mogler, Mark, Kurt I. Kamrud, Jill Gander, and D. L. Hank Harris. Expression and Immunogenicity of an Alphavirus Replicon African Swine Fever Virus Vaccine Candidate in Swine. Iowa State University, 2013. http://dx.doi.org/10.31274/ans_air-180814-861.

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Wang, X. F., and M. Schuldiner. Systems biology approaches to dissect virus-host interactions to develop crops with broad-spectrum virus resistance. United States-Israel Binational Agricultural Research and Development Fund, 2020. http://dx.doi.org/10.32747/2020.8134163.bard.

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Abstract:

More than 60% of plant viruses are positive-strand RNA viruses that cause billion-dollar losses annually and pose a major threat to stable agricultural production, including cucumber mosaic virus (CMV) that infects numerous vegetables and ornamental trees. A highly conserved feature among these viruses is that they form viral replication complexes (VRCs) to multiply their genomes by hijacking host proteins and remodeling host intracellular membranes. As a conserved and indispensable process, VRC assembly also represents an excellent target for the development of antiviral strategies that can b

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