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Journal articles on the topic 'Alps'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Kvam, Augusta I., Rooyen T. Mavenyengwa, Andreas Radtke, and Johan A. Maeland. "Streptococcus agalactiae Alpha-Like Protein 1 Possesses Both Cross-Reacting and Alp1-Specific Epitopes." Clinical and Vaccine Immunology 18, no. 8 (2011): 1365–70. http://dx.doi.org/10.1128/cvi.05005-11.

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ABSTRACTMost isolates of group B streptococci (GBS) express an alpha-like protein (Alp), Cα (encoded bybca), Alp1 (also called epsilon;alp1), Alp2 (alp2), Alp3 (alp3), Alp4 (alp4), or R4/Rib (rib). These proteins are chimeras with a mosaic structure and with antigenic determinants with variable immunological cross-reactivities between the Alps, including Alp1 and Cα cross-reactivity. This study focused on antigenic domains of Alp1, studied by using rabbit antisera in immunofluorescence, Western blotting, and enzyme-linked immunosorbent assay (ELISA)-based tests and whole cells of GBS or trypsi

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Maeland, Johan A., Jan E. Afset, Randi V. Lyng, and Andreas Radtke. "Survey of Immunological Features of the Alpha-Like Proteins of Streptococcus agalactiae." Clinical and Vaccine Immunology 22, no. 2 (2014): 153–59. http://dx.doi.org/10.1128/cvi.00643-14.

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ABSTRACTNearly allStreptococcus agalactiae(group B streptococcus [GBS]) strains express a protein which belongs to the so-called alpha-like proteins (Alps), of which Cα, Alp1, Alp2, Alp3, Rib, and Alp4 are known to occur in GBS. The Alps are chimeras which form mosaic structures on the GBS surface. Both N- and C-terminal stretches of the Alps possess immunogenic sites of dissimilar immunological specificity. In this review, we have compiled data dealing with the specificity of the N- and C-terminal immunogenic sites of the Alps. The majority of N-terminal sites show protein specificity while t

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3

Leroux, Erick. "The great crossing of the Alps or move your Alps (GTA)." Worldwide Hospitality and Tourism Themes 10, no. 2 (2018): 236–43. http://dx.doi.org/10.1108/whatt-12-2017-0080.

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Purpose The purpose of this study is to highlight the Grande Traversée des Alpes or – Move your Alps (GTA) which can be regarded as one of the first organizations to promote sustainable tourism in the Alps. Design/methodology/approach The study is based on a case study of the GTA. Findings The GTA is a key case study for understanding stakeholders’ management and sustainable tourism in the Alps. Originality/value There has been insufficient attention given in the literature to the role of the GTA, especially given its importance in the promotion of sustainable tourism in the Alps.

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4

Zhao, Zuotao, Fanrong Kong, and Gwendolyn L. Gilbert. "Reverse Line Blot Assay for Direct Identification of Seven Streptococcus agalactiae Major Surface Protein Antigen Genes." Clinical and Vaccine Immunology 13, no. 1 (2006): 145–49. http://dx.doi.org/10.1128/cvi.13.1.145-149.2006.

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ABSTRACT We developed a multiplex PCR-based reverse line blot hybridization assay (mPCR/RLB) to detect the genes encoding members of the family of variable surface-localized proteins of Streptococcus agalactiae (group B streptococcus [GBS]), namely, Bca (Cα), Rib, Epsilon (Epsilon/Alp1/Alp5), Alp2, Alp3, and Alp4, and the immunoglobulin A binding protein, Bac (Cβ). We used the assay to identify these genes in a collection of well-characterized GBS isolates and reference strains. The results showed that mPCR/RLB avoids the common problems of cross-reaction and nontypability associated with prot

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5

Winterle, Alberto. "Leggere le Alpi / Reading the Alps." Regionalità e produzione architettonica contemporanea nelle Alpi, no. 1 ns, november 2018 (November 15, 2018): 202–6. http://dx.doi.org/10.30682/aa1801v.

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Living a place means first of all reading it, understanding it, assimilating it. This is even more evident in the case of a particular natural environment where the possibilities of land use are limited. Looking at a map of the Alps, it becomes clear how the morphology has conditioned the methods of settlement and exploitation of the places. In an attempt to read and interpret the transformation of the Alpine territories, the Architetti Arco Alpino association has initiated a review of projects, from which it emerges that today there exist very different cultural, political, social and economi

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6

Price, Martin F. "Alpenatlas—Atlas des Alpes—Atlante delle Alpi—Atlas Alp—Mapping the Alps: Society—Economy—Environment." Mountain Research and Development 29, no. 3 (2009): 292. http://dx.doi.org/10.1659/mrd.mm057.

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7

Tretow-Fish, Tobias Alexander Bang, and Md Saifuddin Khalid. "Methods for Evaluating Learning Analytics and Learning Analytics Dashboards in Adaptive Learning Platforms: A Systematic Review." Electronic Journal of e-Learning 21, no. 5 (2023): 430–49. http://dx.doi.org/10.34190/ejel.21.5.3088.

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This research paper highlights and addresses the lack of a systematic review of the methods used to evaluate Learning Analytics (LA) and Learning Analytics Dashboards (LAD) of Adaptive Learning Platforms (ALPs) in the current literature. Addressing this gap, the authors built upon the work of Tretow-Fish and Khalid (2022) and analyzed 32 papers, which were grouped into six categories (C1-6) based on their themes. The categories include C1) the evaluation of LA and LAD design and framework, C2) the evaluation of user performance with LA and LAD, C3) the evaluation of adaptivity, C4) the evaluat

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8

Simmel, Georg. "The Alps." Qualitative Sociology 16, no. 2 (1993): 179–84. http://dx.doi.org/10.1007/bf00989749.

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9

Peterson, Katie. "The Alps." Literary Imagination 27, no. 2 (2025): 130–32. https://doi.org/10.1353/lim.2025.a965368.

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10

Palmisani, E., M. Miano, T. Lanza, et al. "PF351 ALPS DISEASE AND ALPS PHENOTYPE: DISTINCT ENTITIES?" HemaSphere 3, S1 (2019): 127. http://dx.doi.org/10.1097/01.hs9.0000559616.91240.a0.

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11

Seif, Alix E., Catherine S. Manno, Cecilia Sheen, Stephan A. Grupp, and David T. Teachey. "Identifying autoimmune lymphoproliferative syndrome in children with Evans syndrome: a multi-institutional study." Blood 115, no. 11 (2010): 2142–45. http://dx.doi.org/10.1182/blood-2009-08-239525.

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Abstract Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of abnormal lymphocyte survival caused by dysregulation of the Fas apoptotic pathway. Clinical manifestations of ALPS include autoimmune cytopenias, organomegaly, and lymphadenopathy. These findings overlap with Evans syndrome (ES), defined by presence of at least 2 autoimmune cytopenias. We hypothesized a subset of patients with ES have ALPS and tested 45 children at 22 institutions, measuring peripheral blood double-negative T cells (DNTs) and Fas-mediated apoptosis. ALPS was diagnosed in 47% of patients tested. Markedly e

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Molnár, Emese, Nesrine Radwan, Gábor Kovács, et al. "Key diagnostic markers for autoimmune lymphoproliferative syndrome with molecular genetic diagnosis." Blood 136, no. 17 (2020): 1933–45. http://dx.doi.org/10.1182/blood.2020005486.

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Abstract Autoimmune lymphoproliferative syndrome (ALPS) is a rare immunodeficiency caused by mutations in genes affecting the extrinsic apoptotic pathway (FAS, FASL, CASP10). This study evaluated the clinical manifestations, laboratory findings, and molecular genetic results of 215 patients referred as possibly having ALPS. Double-negative T-cell (DNT) percentage and in vitro apoptosis functional tests were evaluated by fluorescence-activated cell sorting; interleukin 10 (IL-10) and IL-18 and soluble FAS ligand (sFASL) were measured by enzyme-linked immunosorbent assay. Genetic analysis was pe

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Rao, V. Koneti, Jorge A. Carrasquillo, Janet K. Dale, et al. "Whole-Body Positron Emission Tomography (PET) Using 2-18Fluoro-2-Deoxy-D-Glucose (FDG) for Monitoring Lymphadenopathy in Autoimmune Lymphoproliferative Syndrome (ALPS)." Blood 104, no. 11 (2004): 3850. http://dx.doi.org/10.1182/blood.v104.11.3850.3850.

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Abstract ALPS is associated with mutations in genes that promote apoptosis of lymphocytes leading to accumulation of unwanted cells, including ones that react against self antigens. It is characterized by early childhood onset of chronic lymphadenopathy, hepatosplenomegaly and autoimmune cytopenias. ALPS Types Ia, Ib, IIa and IIb are associated with mutations in the genes encoding the apoptosis signaling proteins Fas, FasL, and Caspases 10 or 8 respectively, while patients in whom no mutations have been identified are classified as ALPS Type III. Patients with intracellular Fas mutations have

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14

Leuzinger, Urs, Martin Trüssel, Martin Berweger, et al. "Archäologische Untersuchungen in zwei Balmen am Weg zum Surenenpass in der Gemeinde Engelberg OW." Jahrbuch Archäologie Schweiz 106 (2023) (June 1, 2023): 161–66. https://doi.org/10.5281/zenodo.7895484.

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<em>Keywords: Alpen; Feuerstellen; Holzkohle; Jüngere Eisenzeit; Faunenreste; Mollusken; historische Inschriften. – Alpes ; foyers ; charbons de bois ; Âge du Fer récent ; restes de faune ; mollusques ; inscriptions historiques. – Alpi; focolari; carbone di legno; età del ferro recente; resti faunistici; iscrizioni storiche. – Alps; hearths; charcoal; Later Iron Age; animal remains; molluscs; historical inscriptions.</em>

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15

Takagi, Masatoshi, Kohsuke Imai, Jinhua Piao, et al. "Whole-Exome Analysis of Autoimmune Lymphoproliferative Syndrome-like Diseases." Blood 126, no. 23 (2015): 1022. http://dx.doi.org/10.1182/blood.v126.23.1022.1022.

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Abstract ALPS is characterized by chronic lymphoproliferation in combination with autoimmunity; mutations of molecules involved in FAS-dependent pathways play causative roles in this syndrome. The hallmarks of ALPS are an elevated CD4/CD8 double-negative T (DNT) cell count and attenuated induction of apoptosis by FAS stimulation. Autoimmune thrombocytopenia and/or hemolytic anemia are common in cases of ALPS; the combination of autoimmune thrombocytopenia and hemolytic anemia is referred to as Evans syndrome. ALPS is diagnosed in 47% of patients who present with Evans syndrome. Some patients w

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Cojocaru, Manole, Inimioara Cojocaru, Isabela Silosi, and Camelia Vrabie. "Autoimmune Lymphoproliferative Syndrome." Journal of Medical Biochemistry 29, no. 1 (2010): 15–18. http://dx.doi.org/10.2478/v10011-010-0006-y.

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Autoimmune Lymphoproliferative SyndromeThe autoimmune lymphoproliferative syndrome (ALPS) is a rare disease. ALPS is an inherited condition that affects both sexes. ALPS is not cancer, it is not infectious, and its incidence has not yet been estimated. ALPS generally does not lead to death and most individuals with ALPS are able to live normal lives. ALPS is a disorder associated with abnormal lymphocyte apoptosis, lymphoproliferation, and autoimmunity. Serologic testing is critical in the evaluation of these individuals. Lymphoproliferation in ALPS patients is generally benign, but they are a

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Perkins, Katie, Joie Davis, Susan Price, et al. "Expanding Spectrum of Malignancies in ALPS: A Cancer Predisposing Syndrome?." Blood 120, no. 21 (2012): 2149. http://dx.doi.org/10.1182/blood.v120.21.2149.2149.

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Abstract Abstract 2149 Background: Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of apoptosis characterized by lymphadenopathy, splenomegaly and peripheral accumulation of TCR αβ+ CD4-/CD8- double-negative T lymphocytes (DNT cells), often leading to multilineage cytopenias. ALPS-FAS with germline FAS mutations is the most common form of ALPS and has been associated with an increased risk for lymphoma (Straus, Blood 2001). We have now identified additional malignancies in our cohort, further underscoring the importance of cancer surveillance in ALPS patients. Objective: This is a

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18

Tian, Bin, Chen Zhao, Jia-Li Liang, et al. "Glymphatic function and its influencing factors in different glucose metabolism states." World Journal of Diabetes 15, no. 7 (2024): 1537–50. http://dx.doi.org/10.4239/wjd.v15.i7.1537.

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BACKGROUND Dysfunction of the glymphatic system in the brain in different stages of altered glucose metabolism and its influencing factors are not well characterized. AIM To investigate the function of the glymphatic system and its clinical correlates in patients with different glucose metabolism states, the present study employed diffusion tensor imaging along the perivascular space (DTI-ALPS) index. METHODS Sample size was calculated using the pwr package in R software. This cross-sectional study enrolled 22 patients with normal glucose metabolism (NGM), 20 patients with prediabetes, and 22

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Takagi, Masatoshi, Kunihiro Shinoda, Jinhua Piao, et al. "Autoimmune lymphoproliferative syndrome–like disease with somatic KRAS mutation." Blood 117, no. 10 (2011): 2887–90. http://dx.doi.org/10.1182/blood-2010-08-301515.

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Abstract Autoimmune lymphoproliferative syndrome (ALPS) is classically defined as a disease with defective FAS-mediated apoptosis (type I-III). Germline NRAS mutation was recently identified in type IV ALPS. We report 2 cases with ALPS-like disease with somatic KRAS mutation. Both cases were characterized by prominent autoimmune cytopenia and lymphoadenopathy/splenomegaly. These patients did not satisfy the diagnostic criteria for ALPS or juvenile myelomonocytic leukemia and are probably defined as a new disease entity of RAS-associated ALPS-like disease (RALD).

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20

Miano, Maurizio, Andrea Todiere, Ilaria Caviglia, et al. "Autoimmune Lymphoproliferative Syndrome (ALPS) and ALPS-Related Disorders. Different Bio-Clinical Profile and Similar Response to Treatment: A Single Centre Experience." Blood 126, no. 23 (2015): 4618. http://dx.doi.org/10.1182/blood.v126.23.4618.4618.

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Abstract ALPS is an inherited disorder characterized by lymphoproliferation and autoimmunity that mainly involves blood cells. In the last few years, new disorders other than ALPS have been found to cause lymphoproliferative syndromes, and many patients with similar clinical features but not fitting ALPS diagnostic criteria have been described. In this study we evaluate clinical features and response to the treatment of patients with ALPS and ALPS-related Syndromes (ARS) followed in a single Center. ALPS was defined according to the revised diagnostic criteria (first international Workshop, 20

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Bleesing, Jack J. H., Margaret R. Brown, Stephen E. Straus, et al. "Immunophenotypic profiles in families with autoimmune lymphoproliferative syndrome." Blood 98, no. 8 (2001): 2466–73. http://dx.doi.org/10.1182/blood.v98.8.2466.

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Abstract Autoimmune lymphoproliferative syndrome (ALPS) type Ia is caused by inherited defects in apoptosis and is characterized by nonmalignant lymphoaccumulation, autoimmunity, and increased α/β+ double-negative T cells (α/β+-DNT cells). This study reports immunophenotypic findings in 166 members of 31 families with ALPS type Ia, associated with genetic mutations in theTNFRSF6 gene encoding Fas. The ALPS type Ia probands (n = 31) and relatives having both a Fas mutation and clinically proven ALPS (n = 28) showed significant expansion of CD8+T cells, α/β+-DNT cells, γ/δ+-DNT cells, CD3+/ HLA-

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Teachey, David T. "Using the Genetics of the Autoimmune Lymphoproliferative Syndrome to Guide Therapy." Blood 116, no. 21 (2010): SCI—7—SCI—7. http://dx.doi.org/10.1182/blood.v116.21.sci-7.sci-7.

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Abstract Abstract SCI-7 Autoimmune Lymphoproliferative Syndrome (ALPS) is a disorder of abnormal lymphocyte survival caused by defective Fas-mediated apoptosis. Patients with ALPS may present with lymphoproliferation (lymphadenopathy and hepatosplenomegaly), autoimmune disease (most commonly autoimmune cytopenias), and secondary malignancies (typically EBER+ non-Hodgkin lymphoma). Eighty percent of ALPS patients have an identifiable genetic mutation in FAS (TNFRSF6), FASL (TNFSF6), or CASP10. These mutations can be germline or somatic with localization to the double negative T cell (DNT) compa

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23

Michl, Thomas, Stefan Huck, Peter Haase, and Burkhard Büdel. "Genetic Differentiation among Populations of Cicerbita alpina (L.) Wallroth (Asteraceae) in the Western Alps." Zeitschrift für Naturforschung C 62, no. 9-10 (2007): 747–56. http://dx.doi.org/10.1515/znc-2007-9-1019.

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In this study we analyzed the genetic population structure of the hygrophilous tall-herb Cicerbita alpina in the western Alps because this group of mountain plants is underrepresented in the biogeographical literature. AFLP (amplified fragment length polymorphism) fingerprints of 40 samples were analyzed from four populations situated in a transect from the southwestern Alps to the eastern part of the western Alps and one population from the Black Forest outside the Alps. Two genetic groups can be distinguished. The first group (A) comprises the populations from the northern and eastern parts

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Neven, Bénédicte, Aude Magerus-Chatinet, Benoit Florkin, et al. "A survey of 90 patients with autoimmune lymphoproliferative syndrome related to TNFRSF6 mutation." Blood 118, no. 18 (2011): 4798–807. http://dx.doi.org/10.1182/blood-2011-04-347641.

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Abstract Autoimmune lymphoproliferative syndrome (ALPS) is a genetic disorder characterized by early-onset, chronic, nonmalignant lymphoproliferation, autoimmune manifestations, and susceptibility to lymphoma. The majority of ALPS patients carry heterozygous germline (ALPS-FAS) or somatic mutations (ALPS-sFAS) of the TNFRSF6 gene coding for FAS. Although the clinical features of ALPS have been described previously, long-term follow-up data on morbidity and mortality are scarce. We performed a retrospective analysis of clinical and genetic features of 90 ALPS-FAS and ALPS-sFAS patients monitore

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25

Buck, Maria. "Von den bedrohlichen zu den bedrohten Alpen – Aneignungsprozesse und Identifikationsfiguren alpiner Umweltschützer*innen in Tirol." Góry, Literatura, Kultura 14 (August 17, 2021): 121–36. http://dx.doi.org/10.19195/2084-4107.14.10.

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While in the early days of the European history of culture the Alps were seen as forbidding, since the 1970s environmental activists have used this description, turning it the other way round — now it is the Alps that are increasingly threatened by today’s environmental problems. Noise, air pollution, deforestation and problems relating to ozone depletion threaten the ecologically sensitive Alpine range. The problems affect not just the Alps, but owing to geographical and topographic conditions their consequences are particularly strong here. Thus the Alps constitute a reference framework as w

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Buck, Maria. "Od groźnych po zagrożone Alpy — procesy zawłaszczania i tożsamość alpejskich obrońców środowiska w Tyrolu." Góry, Literatura, Kultura 14 (August 17, 2021): 137–49. http://dx.doi.org/10.19195/2084-4107.14.11.

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While in the early days of the European history of culture the Alps were seen as forbidding, since the 1970s environmental activists have used this description, turning it the other way round — now it is the Alps that are increasingly threatened by today’s environmental problems. Noise, air pollution, deforestation and problems relating to ozone depletion threaten the ecologically sensitive Alpine range. The problems affect not just the Alps, but owing to geographical and topographic conditions their consequences are particularly strong here. Thus the Alps constitute a reference framework as w

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27

Caminha, Iusta, Thomas Fleisher, Julie Niemela, et al. "Identifying Biomarkers in the Autoimmune Lymphoproliferative Syndrome (ALPS): IL-18, TNF-á, Serum Vitamin B12, Soluble FasL, and Plasma IL-10 Levels Are Useful Adjuvant Diagnostic Tools." Blood 114, no. 22 (2009): 1647. http://dx.doi.org/10.1182/blood.v114.22.1647.1647.

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Abstract Abstract 1647 Poster Board I-673 Introduction The autoimmune lymphoproliferative syndrome (ALPS) is a genetic disorder of lymphocyte apoptosis. Clinical findings include lymphadenopathy, splenomegaly, multi-lineage cytopenias, hypergammaglobulinemia and an increased risk for lymphoid malignancies. Nearly 65 % of ALPS patients have a heterozygous mutation in the TNFRSF6 gene coding for the FAS protein. Recently, analysis of selected biomarkers in a smaller group of ALPS patients has been reported (Blood.2009Mar26;113(13):3027-30). However, there is currently no algorithm to predict the

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Dowdell, Kennichi, Julie Niemela, Susan Price, et al. "Somatic Fas Mutations Account for Nearly One Third of Autoimmune Lymphoproliferative Syndrome (ALPS) Cases with Previously Unknown Genetic Mutations." Blood 114, no. 22 (2009): 710. http://dx.doi.org/10.1182/blood.v114.22.710.710.

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Abstract Abstract 710 Background: Autoimmune lymphoproliferative syndrome (ALPS) is characterized by childhood onset of lymphadenopathy, hepatosplenomegaly, autoimmune cytopenias, elevated (>1%) double negative T (DNT; CD3+, TCRalpha-beta+, CD4−, CD8−, B220+) lymphocytes in peripheral blood and an increased risk of lymphoma; primarily due to impaired lymphocyte apoptosis. Most cases (65%; 173 individuals in our cohort), known as ALPS Type Ia, are associated with dominant heterozygous germline mutations in the gene TNFRSF6 encoding the protein for CD95 (Fas, Apo-1). Another 5% of patients ha

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Huemer, Peter. "Review of the Incurvaria vetulella species-group in the Alps (Lepidoptera: Incurvariidae)." Insect Systematics & Evolution 24, no. 1 (1993): 109–20. http://dx.doi.org/10.1163/187631293x00091.

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AbstractHuemer, P.: Review of the Incurvaria vetulella species-group in the Alps (Lepidoptera: Incurvariidae). Ent. scand. 24: 109-120. Copenhagen, Denmark. April 1993. ISSN 0013-8711. The Incurvaria vetulella species-group in the Alps is defined and reviewed. The following species are recognized: vetulella (Zetterstedt, 1839) (eastern Alps), triglavensis Hauder, 1912 stat. n. (southeastern Alps) and ploessli sp. n. (southwestern Alps). All species are described and/or redefined and adults, male and female genitalia are illustrated. Furthermore, Scandinavian specimens of vetulella and circulel

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Dakskobler, Igor, Andrej Rozman, and Andrej Seliškar. "FOREST AND SCRUB COMMUNITIES WITH GREEN ALDER (ALNUS VIRIDIS) IN SLOVENIA." Hacquetia 12, no. 2 (2013): 95–185. http://dx.doi.org/10.2478/hacq-2013-0012.

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Abstract This paper provides phytosociological tables that describe scrub and forest communities with Alnus viridis in the Slovenian Alps. We described three new associations: Rhododendro hirsuti-Alnetum viridis (a green alder community on calcareous bedrock in the Eastern and Southeastern Alps), Huperzio selagi-Alnetum viridis (a green alder community in the silicate rocks under Mt. Komen in the eastern Savinja Alps) and Alno viridis- Sorbetum aucupariae (a successional stage of mountain ash and green alder on potential beech sites in the foothills of the southern Julian Alps; similar stages

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31

Eiler, John. "Alps as Inspiration." Elements 17, no. 1 (2021): 3. http://dx.doi.org/10.2138/gselements.17.1.3.

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Khalidullin, Oleg. "Alps and climate." Annals of Civil and Environmental Engineering 4, no. 1 (2020): 001–2. http://dx.doi.org/10.29328/journal.acee.1001018.

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PORCELLI, SIMONE, Letizia Rasica, Desy Salvadego, et al. "“BEet On Alps”." Medicine & Science in Sports & Exercise 49, no. 5S (2017): 240. http://dx.doi.org/10.1249/01.mss.0000517509.75768.2f.

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Lampinen, Antti. "Breaching the Alps." History in flux 3, no. 3 (2021): 7–28. http://dx.doi.org/10.32728/flux.2021.3.1.

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The Roman preoccupation with the Alps as the tutamen of Italy owed its epistemic immediacy to a much more recent event—the Cimbric Wars (113-101 BCE). This traumatic episode had reawakened imagery of the northern enemies penetrating the “Wall of Italy,” which in some cases went all the way back to the Mid-Republican narrative traditions of the Gallic Invasions and the much more frequently debated shock of Hannibal’s invasion. The significance of this imagery continued even beyond the Augustan era, so that remnants of the same Roman insecurity about the “Wall of Italy” being breached, especiall

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35

Feder, Toni. "Trans-Alps neutrinos." Physics Today 59, no. 11 (2006): 36. http://dx.doi.org/10.1063/1.2435643.

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McClain, Kenneth L., and Nitya Gulati. "ALPS or not?" Blood 136, no. 17 (2020): 1895–96. http://dx.doi.org/10.1182/blood.2020007418.

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Salvadego, Desy, Mauro Marzorati, Letizia Rasica, and Simone Porcelli. "“BEet On Alps”." Medicine & Science in Sports & Exercise 49, no. 5S (2017): 849–50. http://dx.doi.org/10.1249/01.mss.0000519290.79391.af.

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38

Mikael, Hedrén, E. Anghelescu Nora, and Lorenz Richard. "Geographic differentiation in Nigritella nigra s.l. from the Pyrenees, the Jura, the Eastern Alps and the Southern Carpathians." Journal Europäischer Orchideen 54, no. 3-4 (2022): 266–328. https://doi.org/10.5281/zenodo.7856133.

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Dark-coloured, apomictic and polyploid members of the <strong><em>Nigritella nigra s.l.</em></strong> complex are distributed over major European mountain regions. Here, we analysed the differentiation between regional populations in molecular markers and morphology. Based on nuclear SSR marker data, populations from the Pyrenees were closely similar to those in the Western Alps and the Jura Mountains, but were differentiated from those in the Eastern Alps. In the Eastern Alps, populations from the Northern Calcareous Alps were minimally differentiated from populations in the Southern Calcareo

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Pšenička, Josef, Stanislav Opluštil, Ausonio Ronchi, and Zbyněk Šimůnek. "Revision of the Pennsylvanian Flora from Val Sanagra in Western Part of the Southern Alps (Italy)." Folia Musei rerum naturalium Bohemiae occidentalis. Geologica et Paleobiologica 46, no. 1-2 (2012): 31–79. http://dx.doi.org/10.2478/fbgp-2013-0003.

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Abstract The Pennsylvanian flora from the Alpe Logone/Val Sanagra locality in the Western Lombardy (Southern Alps, Italy) last underwent a taxonomic study in the mid 20th century. The main problem is generally poor preservation of the plant remains, which makes their identification problematic. Despite this, the authors have identified 43 fossil species from this locality. Based on the sedimentary context of this paleoflora, we assume that the Val Sanagra sediments were deposited in a continental setting, in a fluvial environment with a well-developed and vegetated floodplain where where clast

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Abubakar, Ali, Juliana Juliana та Maisyarah Rahmi Hasan. "The Right of a Child Outside the Legal Marriage of a Biological Father: The Analysis of Ḥifẓ Al-Nafs as Law `Illat". Samarah: Jurnal Hukum Keluarga dan Hukum Islam 5, № 1 (2021): 153. http://dx.doi.org/10.22373/sjhk.v5i1.9256.

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This article aims to analyze the protection of life (ḥifẓ al-nafs) as the law reason (`illat) of the rights of children outside of legal marriage (ALPS) of biological fathers. Ḥifẓ al-nafs is assumed to be `illat emerging from many neglected ALPS phenomena and resulting in negative stigma and discrimination. This research is a study of Islamic law using the theory of `illat in analyzing the problem of children's rights outside of legal marriage. The research concludes that the presence of the 2010 Constitutional Court decision regarding the civil rights of ALPS with biological fathers reveals

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Dowdell, Kennichi C., Julie Niemela, Janet K. Dale, et al. "Role of Somatic Fas Mutations in the Pathogenesis of Autoimmune Lymphoproliferative Syndrome (ALPS)." Blood 108, no. 11 (2006): 3900. http://dx.doi.org/10.1182/blood.v108.11.3900.3900.

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Abstract ALPS is a disorder of lymphocyte apoptosis associated with expansion of double negative T cells (DNT; TCRα/β+CD3+CD4−CD8−), an in vitro apoptosis defect and affected individuals typically present in early childhood with nonmalignant lymphadenopathy, splenomegaly, and multilineage cytopenias due to splenic sequestration and/or peripheral autoimmune destruction. ALPS classifications include Type Ia, Ib, and II associated with mutations in Fas, FasL, and Caspases, respectively, and Type III when the apoptosis pathway mutation is unidentified. Among our cohort of more than 200 patients, A

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Teachey, David T., Dana A. Obzut, Kelly Axsom, et al. "Rapamycin improves lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome (ALPS)." Blood 108, no. 6 (2006): 1965–71. http://dx.doi.org/10.1182/blood-2006-01-010124.

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Abstract Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of abnormal lymphocyte survival caused by defective Fas-mediated apoptosis, leading to lymphadenopathy, hepatosplenomegaly, and an increased number of double-negative T cells (DNTs). Treatment options for patients with ALPS are limited. Rapamycin has been shown to induce apoptosis in normal and malignant lymphocytes. Since ALPS is caused by defective lymphocyte apoptosis, we hypothesized that rapamycin would be effective in treating ALPS. We tested this hypothesis using rapamycin in murine models of ALPS. We followed treatme

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Dowdell, Kennichi C., Julie E. Niemela, Susan Price, et al. "Somatic FAS mutations are common in patients with genetically undefined autoimmune lymphoproliferative syndrome." Blood 115, no. 25 (2010): 5164–69. http://dx.doi.org/10.1182/blood-2010-01-263145.

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Abstract Autoimmune lymphoproliferative syndrome (ALPS) is characterized by childhood onset of lymphadenopathy, hepatosplenomegaly, autoimmune cytopenias, elevated numbers of double-negative T (DNT) cells, and increased risk of lymphoma. Most cases of ALPS are associated with germline mutations of the FAS gene (type Ia), whereas some cases have been noted to have a somatic mutation of FAS primarily in their DNT cells. We sought to determine the proportion of patients with somatic FAS mutations among a group of our ALPS patients with no detectable germline mutation and to further characterize t

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Ke, Zhihong, Yuting Mo, Jiangnan Li, et al. "Glymphatic Dysfunction Mediates the Influence of White Matter Hyperintensities on Episodic Memory in Cerebral Small Vessel Disease." Brain Sciences 12, no. 12 (2022): 1611. http://dx.doi.org/10.3390/brainsci12121611.

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Glymphatic dysfunction has been linked to cognitive decline in several neurodegenerative diseases. In cerebral small vessel disease (CSVD), the mechanism of white matter hyperintensities (WMH)-related cognitive impairment (CI) is still under investigation. The diffusion tensor image (DTI) analysis along the perivascular space (ALPS) method has been considered to be a reliable parameter to evaluate glymphatic function. Therefore, we applied the ALPS-index to determine the influence of glymphatic function on CI in CSVD. In total, 137 CSVD patients (normal cognitive group, mild CI group, and deme

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Zhang, Qiyuan, Haiyan Wang, Aiyun Zhao, et al. "Molecular detection of Enterocytozoon bieneusi in alpacas (Vicugna pacos) in Xinjiang, China." Parasite 26 (2019): 31. http://dx.doi.org/10.1051/parasite/2019031.

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Enterocytozoon bieneusi, an obligate intracellular pathogen, can infect a wide variety of hosts. This study aimed to determine the prevalence and molecular characteristics of E. bieneusi in alpacas (Vicugna pacos) in China. A total of 185 alpaca fecal samples were collected from five herds in Tacheng, Wensu, Hejing, Qinghe, and Nilka counties in Xinjiang Uygur Autonomous Region. Enterocytozoon bieneusi was detected by nested PCR of the internal transcribed spacer (ITS) region. Twenty-eight fecal samples (15.1%, 28/185) were positive for E. bieneusi, with the highest prevalence in alpacas from

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Allen, Giancarlo. "Biodiversità, Alpi, Architettura. Esperienze dal premio Constructive Alps." Archalp 09, no. 2022 (2023). http://dx.doi.org/10.30682/aa2209l.

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Due to their geographical, orographic, cultural, and historical characteristics, the Alps can be considered a vast park, representing a reservoir of biological diversity in the centre of Europe; however, such biodiversity is at serious risk. The Alps are breath-taking in their nature, with their peaks, trees, water, animals, insects, people and languages, as well as in their impressing architecture made of the same materials as forests and rocks. On the other hand, the Alps currently count 120 million tourists a year, they are compromised by industries, motorways, cities, consumption, their fo

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Michalet, Richard, Ida Delpy, Auriane Eisenberg, et al. "Changes in species richness with climate change in subalpine communities are dependent on regional environmental conditions and local functional composition." Journal of Vegetation Science 35, no. 2 (2024). http://dx.doi.org/10.1111/jvs.13254.

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AbstractQuestionsClimate change may have different effects on species richness depending on regional climates, soil types and the functional composition of local communities.LocationSubalpine belt of the Grandes Rousses (Alps) and Sancy mountain ranges (the Massif Central), France.MethodsWe compared changes in species richness in response to recent climate change in communities from two mountain ranges subjected to contrasting environmental conditions, with a more continental climate and drier soils in the Alps than in the Massif Central. Vegetation composition of 189 and 157 plots was assesse

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Xu, Xinxiu, James Denton, Yaning Wu, et al. "Genetic Testing in Patients with Autoimmune Lymphoproliferative Syndrome: Experience of 802 Patients at Cincinnati Children’s Hospital Medical Center." Journal of Clinical Immunology 44, no. 7 (2024). http://dx.doi.org/10.1007/s10875-024-01772-z.

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AbstractAutoimmune lymphoproliferative syndrome (ALPS) is a rare genetic disorder featuring chronic lymphadenopathy, splenomegaly, cytopenias, and increased lymphoma risk. Differentiating ALPS from immunodeficiencies with overlapping symptoms is challenging. This study evaluated the performance and the diagnostic yield of a 15-gene NGS panel for ALPS at Cincinnati Children’s Hospital Medical Center. Samples from 802 patients submitted for ALPS NGS panel were studied between May 2014 and January 2023. A total of 62 patients (7.7%) had a definite diagnosis: 52/62 cases (84%) showed 37 unique pat

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Cao, Yungang, Mei Huang, Fangwang Fu, et al. "Abnormally glymphatic system functional in patients with migraine: a diffusion kurtosis imaging study." Journal of Headache and Pain 25, no. 1 (2024). http://dx.doi.org/10.1186/s10194-024-01825-z.

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Abstract Background The diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) method has been used to evaluate glymphatic system function in patients with migraine. However, since the diffusion tensor model cannot accurately describe the diffusion coefficient of the nerve fibre crossing region, we proposed a diffusion kurtosis imaging ALPS (DKI-ALPS) method to evaluate glymphatic system function in patients with migraine. Methods The study included 29 healthy controls and 37 patients with migraine. We used diffusion imaging data from a 3T MRI scanner to calculate DTI-ALPS a

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Carmona, Adrian, Christiane Scherb, and Pedro Schwaller. "Charming ALPs." Journal of High Energy Physics 2021, no. 8 (2021). http://dx.doi.org/10.1007/jhep08(2021)121.

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Abstract Axion-like particles (ALPs) are ubiquitous in models of new physics explaining some of the most pressing puzzles of the Standard Model. However, until relatively recently, little attention has been paid to its interplay with flavour. In this work, we study in detail the phenomenology of ALPs that exclusively interact with up-type quarks at the tree-level, which arise in some well-motivated ultra-violet completions such as QCD-like dark sectors or Froggatt-Nielsen type models of flavour. Our study is performed in the low-energy effective theory to highlight the key features of these sc

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