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Dissertations / Theses on the topic 'Alstonine'

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1

Linck, Viviane de Moura. "Perfil antipsicótico de alstonina : ação em modelos de sintomas negativos, alterações em aminas biogênicas e efeitos adversos em camundongos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2008. http://hdl.handle.net/10183/13097.

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A esquizofrenia é um transtorno psiquiátrico grave, caracterizado por distúrbios do pensamento, prejuízo da lógica, alterações cognitivas e emocionais, e/ou isolamento social. Apesar da introdução de novos antipsicóticos, um grupo considerável de pacientes ainda é refratário aos tratamentos disponíveis. Além disso, a alta incidência de efeitos adversos leva à baixa adesão ao tratamento em esquizofrênicos. O desenvolvimento de tratamentos mais eficazes e com menor incidência de efeitos adversos, que aumentem a adesão ao tratamento e melhorem a qualidade de vida destes pacientes, é assim altamen
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2

Arnold, Megan. "Investigating natural products as new drug leads for malaria." Thesis, Griffith University, 2018. http://hdl.handle.net/10072/381398.

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Despite being preventable and treatable, malaria continues to be a significant threat to global health, particularly in the developing world. It is estimated that 90% of all malaria deaths occur in Africa and that 78% of these deaths occur in children under five years of age due to infection with Plasmodium falciparum malaria parasites. While malaria control strategies, together with the global malaria eradication agenda, has resulted in a 48% decline in global malaria mortality rates over the past decade, progress has stalled. A recent rise in malaria cases is particularly concerning given th
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3

Linck, Viviane de Moura. "Modulação de vias serotonérgicas e dopaminérgicas por alstonina : possível inovação no mecanismo de ação de antipsicóticos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2012. http://hdl.handle.net/10183/142804.

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Ainda que descrita pela primeira vez em 1893 por Emil Kraepelin, a esquizofrenia continua sendo uma doença mental extremamente debilitante e de difícil tratamento. A introdução dos antipsicóticos típicos na década de 50 e dos atípicos na década de 90 mudou consideravelmente a realidade dos esquizofrênicos, no entanto a baixa eficácia (principalmente quanto aos sintomas negativos e cognitivos) associada a alta incidência de efeitos adversos requer inovação na farmacodinâmica de antipsicóticos. Alstonina, um alcaloide indólico, é o componente majoritário de uma preparação utilizada para tratar p
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4

Rahn, Volker Siegfried. "Synthetic studies towards the total synthesis of (-)-alstonerine." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.401724.

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5

Pett, Richard. "Total synthesis of the macroline-related alkaloid (±)-alstonerine." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/17842.

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This thesis examines the total synthesis of the macroline-related indole alkaloid alstonerine and related compounds. It is divided into three sections: The first section provides a review of the total synthesis efforts reported by Cook, Martin, Kuethe, and Kwon, as well previous work within the Craig group. The second section discusses the results of our investigations. The optimisation of the synthesis of key intermediate α,β-unsaturated lactam alcohol via directed-aziridine ring-opening is presented in detail. Our progress towards the synthesis of macroline-related alkaloids macroline, alsto
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6

Nkiliza, Jean. "Synthèse totale de la 19-hydroxytubotaïwine et préparation d'indoloazépines de type Iboga." Bordeaux 2, 1990. http://www.theses.fr/1990BOR2B002.

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7

Keawpradub, Niwat. "Studies on the bioactivity and alkaloids of three Thai alstonia species." Thesis, King's College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286253.

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8

Hundley, Nicholas James. "Structure Elucidation of Bioactive Compounds Isolated from Endophytes of Alstonia scholaris and Acmena graveolens." Diss., CLICK HERE for online access, 2005. http://contentdm.lib.byu.edu/ETD/image/etd1013.pdf.

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9

Mesbah, Khaled. "Alcaloides de quatre especes de la famille des apocynaceae : vallesia glabra, aspidosperma macrocarpon, alstonia brassii et peschiera benthamiana (doctorat : pharmacognosie)." Reims, 1997. http://www.theses.fr/1997REIMP205.

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10

Ahamada, Kadiria. "Stratégies biomimétiques en vue de la synthèse totale de deux substances naturelles polycycliques complexes : la bipléiophylline et l'haliclonine A." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA114807/document.

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Les travaux présentés concernent dans une première partie la synthèse biomimétique d’un alcaloïde indolomonoterpénique : la bipléiophylline. La bipléiophylline est le résultat de l’assemblage complexe de deux unités indoliques identiques ancrées sur une plateforme aromatique. Une stratégie générale de synthèse biomimétique de la bipléiophylline consistant i) à la synthèse de l’unité indolique pléiocarpamine et ii) à l’oxydation de l’acide 2,3-dihydroxybenzoïque a été envisagée. L’accès au squelette complexe de la pléiocarpamine a été étudié selon plusieurs stratégies de synthèse totale mais ég
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11

Hnat, Peter. "Systémy L gramatik." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2018. http://www.nusl.cz/ntk/nusl-385974.

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Master thesis deals with L grammar systems. The basic types of grammar systems are studied. There are analyzed different types of L grammars and their use in field of plant development simulation. The work focuses on open L grammars. A parallel system consisting of open L grammars is designed. Communication takes place through the exchange of information between plants and their environment. Implemented is real kind of tree. Simulated is typical environment in which this kind of tree occurs normally. The system properties are examined from the point of view of simulation and the time-consuming
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12

Laplane, Odile. "Contribution à la connaissance des taxons du genre Alstonia de Polynésie française : étude morphologique, génétique, biologique et chimique : thèse présentée pour l'obtention du grade de Docteur en Sciences de l'Université de la Polynésie française et soutenue publiquement le 27 novembre 2010." Polynésie française, 2010. http://www.theses.fr/2010POLF0003.

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Le genre Alstonia(Apocynacées) comprend une cinquantaine d'espèces réparties sur toute la zone pantropicale. En Polynésie française, cinq taxons morphologiquement différents ont été recensés A. Costata var costata, A costata var fragrans, A. Elliptica, A "Moorea" dans l' archipel de la Société et A. Marquisensis dans l'archipel des Marquises. Une étude phytochimique d'A. Costata var costata et A. Marquisensis réalisée par bioguidage suivant deux tests d'activités biologiques (antiradicalaire et inhibiteur de l' acéthylcholinestérase) a permis de révéler leur potentiel pharmacologique. Ces acti
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13

Ramadani, Sabiha, and 莎冰荷. "Analysis of Latex Proteins from Alstonia scholaris." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/8n2733.

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碩士<br>國立屏東科技大學<br>生物科技系所<br>106<br>Alstonia scholaris is a plant that produced latex but the composition of proteins in the latex of A. scholaris is still unknown. In this study, the latex of A. scholaris was extracted for the purification and identification of latex proteins. Five different buffers, named buffer A, B, C, D, and E, were used to optimize the extraction of latex proteins. Five protein bands extracted by buffer D and E were found on the sodium dodecyl sulfate-polyacrylamide gel (SDS-PAGE). A 32 kDa protein band was analyzed using LC/MS/MS, and the result showed that it was an Ann
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14

LI, HAN-WEI, and 李漢偉. "Studies on the Constituents of Alstonia scholaris Bark." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/dm2pru.

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碩士<br>靜宜大學<br>應用化學系<br>106<br>Alstonia scholaris (L.) R. Br. (Apocynaceae) is a large deciduous tree widely distributed in the subtropical regions. This plant was introduced as street tree in Taiwan. In folkloric reputation for medicine, it was used for treating dysentery, malaria, tonics, snake bites and antipyretic. In this study, Alstonia scholaris bark was extracted by 75% methanol-water and 75% acetone-water, respectively. These extraction were isolated by the silica gel in the method of column chromatography and obtained four compounds and two mixtures. These compounds were namely, β-amy
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15

Williams, William Coleman. "Perceptual Disanalogy: On the Alstonian Analogy Argument from Religious Experience." 2009. http://hdl.handle.net/1969.1/ETD-TAMU-2009-08-7211.

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Analogy arguments from religious experience attempt to establish a direct analogy between sense perception and certain kinds of religious experience construed in terms of a perceptual model. C. B. Martin challenges traditional analogy arguments from religious experience by contending that there is a disanalogy between both kinds of experience due to the fact that there is a society of testing and checkup procedures available to sense perception that is not available to religious experience. William P. Alston presents his own analogy argument from religious experience in Perceiving God. Alston
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16

Huang, Mei-Wen, and 黃美汶. "Studies on the Constituent of Leaves of Alstonia scholaris." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/49d9j3.

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碩士<br>靜宜大學<br>應用化學研究所<br>88<br>Form the methanolic extracts of the leaves of Alstonia scholaris (Apocynaceae). picrinine(1),picralinal(2),nareline(3),rhazimal(4),19,20-E-vallesamine(5),β- amyrin(6),and β-sitosterol(7), were isolated and identified by spectroscopic method.
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17

Zahro, Frelyta Ainuz, and 馮琍塔. "Comparison of DNA and RNA Extraction Methods from Alstonia scholaris." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/wf49er.

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碩士<br>國立屏東科技大學<br>生物科技系所<br>106<br>Isolating nucleic acid from plant has given the big challenge because of the rich secondary metabolites. It can interfere not only with the extraction of high-quality nucleic acid but also with the subsequent reaction. In order to add new information on RNA and DNA isolation from Alstonia scholaris, this research aimed to compare the RNA and DNA extraction methods to get the high-quality nucleic acid. The assessment of two DNA extraction and four RNA methods give the different result based on the concentration and the downstream steps. Four primer pairs were
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18

MING, HUNG, and 郭晃銘. "Studies on the Constituent of Fruits and Flowers of Alstonia scholaris." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/52902394220467560809.

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碩士<br>靜宜大學<br>應用化學研究所<br>92<br>Abstract From the methanolic extracts of the fruits and the flowers of Alstonia scholaris (Apocynaceae). picrinine (a) , 19, 20- E-vallesamine (b) , scholaricine (c) , strictamine (d) , rhazimal (e) , methyl cafeate (f) , phytosterols (g ) , glutinol (h) , ursolic acid (i) , cycloeucalenol (j) , α-amyrin acetate and β-amyrin acetate mixture (k) , were isolated and identified by spectroscopic and chemical methods.
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19

Huang, Chia-shung, and 黃家祥. "The Survey of Phylloplane Fungi of Ficus microcarpa and Alstonia scholaris." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/63946279477752403007.

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碩士<br>國立臺南大學<br>生物科技學系碩士班<br>99<br>The purpose of this study was to survey the diversity of phylloplane fungi of Ficus microcarpa Linn. f. and Alstonia scholaris L. R. Brown in Tainan by using solid medium and soil moist chamber culture, fresh leaves with lesions of Ficus and Alstonia were collected in both woods from August, 2008 to January, 2010. A total of 280 plates, twenty eight taxa of phylloplane fungi were isolated on both plants, including members of the Deuteromyces with the highest frequency of occurrence (78.56%), and Ascomycetes, Basidiomycetes. The predominant genera of phyllopla
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20

Lion, Show-Ching, and 劉秀卿. "Study on Carbon Dioxide Fixation Efficiency of sidewalk trees Cytisus pinnatus and Alstonia scholaris." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/90819507236871393431.

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碩士<br>國立臺灣大學<br>森林學研究所<br>91<br>In this study, Cytisus pinnatus on Kuo-Ji Road, a mainline from Tao Yuan(a city in northern Taiwan)to Chung Shan freeway, and Alstonia scholaris on Wen-Chung road were selected. The Carbon Dioxide fixation efficiency, which will be a reference for sidewalk trees planning afterward, was analyzed by measuring net photosynthetic rate, transpiration rate, stomatal conductance rate and other environmental factor outdoor from 8 am to 4 pm, two sunny days a month.
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21

Chen, Hsiao-Ting, and 陳筱婷. "Natural products from Alstonia scholaris and their potential of allelochemical application in sustainable agriculture." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/e5fdvh.

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碩士<br>中國醫藥大學<br>生態暨演化生物學研究所碩士班<br>101<br>Alstonia scholaris, belonging to family Apocynaceae, is also known as devil tree in Southeast Asia and tropical region. A. scholaris is a fast-growing tree that was introduced into Taiwan as roadside tree in1947. A. scholaris exhibits allelopathic phenomenon in the wild fields, but the mechanism is still unclear. Thus, we tried to isolate the natural products from Alstonia scholaris and evaluate their allelochemical properties. The study sites of A. scholaris were set at the Ming-Dao University located in Chang-hua, Taiwan. The major weed in the wild fi
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22

Liu, Fang Yin, and 劉芳吟. "The Influence of Disadvantages of Street Tree on Residents -A Case Syudy on Alstonia Scholaris in Tai-Chung City." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/58419172472646238997.

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碩士<br>東海大學<br>景觀學系<br>91<br>The current study mainly discusses, from the viewpoints of the public, about the street trees planted in the urban cities in terms of problems like inappropriate planting locations and unsuitable plant species that have become a source of troubles for the public. The City Tree of Taichung City—"Alstonia Scholaris," or commonly known as Palimara Alstonia, will be used as the main research species to obtain a deeper understanding on the problems created by Alstonia Scholaris on the citizens of Taichung City, and the severity and difference of between the problems. It
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23

Lin, Chen-Yu, and 林楨祐. "Studies of the production techniques of container nursery stock in Alstonia scholaris (L.) R. Br. and Cinnamomum camphora (Linn.) Sieb." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/93978023380598932235.

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碩士<br>國立臺灣大學<br>園藝學研究所<br>87<br>Nursery stock in cotainer provided an effective, conventient, and economical production methods. However, there were still some disadvantages; for example, greater changes of soil temperature, inferior drainage of the container bottom, and easily occurance of circling root ,etc. The objectives of this study was firstly to determine the advantages and disadvantages of the container grown and the field grown nursery stock, in order to find out the most appropriate method for the growth of Alstonia scholaris and Cinnamomum camphora. We compared the effect of the co
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24

Miller, Kenneth Aaron 1979. "(Rh(CO)₂Cl)₂-catalyzed allylic substitution reactions and domino sequences and application of the Pauson-Khand reaction to the synthesis of azabicyclic structures: total synthesis of (-)-alstonerine." Thesis, 2007. http://hdl.handle.net/2152/3495.

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Examination of the scope of the [Rh(CO)₂Cl]₂-catalyzed allylic substitution reaction as well as the development of a domino [Rh(CO)₂Cl]₂-catalyzed allylic alkylation/Pauson Khand reaction is described. A number of experiments were carried out in order to explore the novel regioselectivity in the [Rh(CO)₂Cl]₂-catalyzed allylic substitution reaction, and the [Rh(CO)₂Cl]₂-catalyzed allylic substitution reaction was found to give products resulting from attack of the nucleophile on the carbon bearing the leaving group in a highly regioselective fashion in most cases. Examination of allylic carb
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25

Tsai, Ben-Yuan, and 蔡本原. "Diurnal Photosynthesis and Carbon Gains in Canopy Leaves of Cinnamomum camphora, Ficus microcarpa, Bischofia javanica, and Alstonia scholaris at Two Different Environments in the China Steel Corporation." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/73258080642406718833.

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碩士<br>國立屏東科技大學<br>森林系<br>94<br>Diurnal and seasonal patterns of photosynthesis in canopy leaves of Cinnamomum camphora, Ficus microcarpa, Bischofia javanica, and Alstonia scholaris were studied at two sites in China Steel Corporation. One was the administration site of less air-polluted and the other was the operation site of highly air-polluted. Measurements were taken from January 2005 to March 2006. The aim of this study was to predict the amount of carbon gains by these trees. Results showed that the highest net photosynthetic rate of the four trees occured in the morning of a day. In spri
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