Relevant bibliographies by topics / Alternative zum Tierversuch

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Alternative zum Tierversuch'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Alternative zum Tierversuch"

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Lilienblum, W. "Toxikologische Stoffdaten für REACH: Alternative Methoden zum Tierversuch – Umsetzung in die Praxis." Chemie Ingenieur Technik 78, no. 9 (September 2006): 1366. http://dx.doi.org/10.1002/cite.200650190.

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Heil, Gudrun, and A. Weber. "Zum Nachweis der Pathogenität von Listerien mittels permanenter Zellinie als Alternative für den Tierversuch." Journal of Veterinary Medicine, Series B 37, no. 1-10 (January 12, 1990): 707–11. http://dx.doi.org/10.1111/j.1439-0450.1990.tb01118.x.

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Lewerenz, H. J. "Alternativen zum Tierversuch. Herausgegeben von F. Lembeck. 284 Seiten, 19 Abb., 5 Tab. Georg Thieme Verlag, Stuttgart, New York 1988. Preis: 33,— DM." Food / Nahrung 32, no. 10 (1988): 1022. http://dx.doi.org/10.1002/food.19880321054.

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Dissertations / Theses on the topic "Alternative zum Tierversuch"

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Gerhardt, Annette. "Teilvalidierung einer Zellkulturmethode als Alternative zum Tierversuch für den Nachweis von Tollwutvirus aus Hirnmaterial /." [S.l.] : [s.n.], 1995. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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Busquet, François. "Development of a new screening assay to identify proteratogenic compounds using Zebrafish Danio rerio embryo combined with an exogenous mammalian metabolic activation system (mDarT)." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2008. http://nbn-resolving.de/urn:nbn:de:bsz:14-ds-1228302283465-60848.

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The assessment of teratogenic effects of chemicals is generally performed using in vivo teratogenicity assays e.g., in rats or rabbits. Following the 3R principles, the development of alternative methods is encouraged to reduce the number of animal tests. From this perspective, we have developed an in vitro assay (mDarT) using the zebrafish Danio rerio embryo teratogenicity assay (DarT) combined with an exogenous mammalian metabolic activation system (MAS), able to biotransform proteratogenic compounds. Cyclophosphamide, ethanol, benzo[a]pyrene and thalidomide were used as test materials to assess the efficiency of this assay. Briefly, the zebrafish embryos were co-cultured at 2 hpf (hours post fertilization) with the test material at varying concentrations, mammalian liver microsomes from different species and NADPH for 60 min at 32°C under moderate agitation in Tris buffer. The negative control (test material alone) and the MAS control (MAS alone) were incubated in parallel. For each test group, 20 eggs were used for statistical robustness. Afterwards fish embryos were transferred individually into 24-well plates filled with fish medium for 48 hours at 26°C with a 12 hour-light cycle. Teratogenicity was scored after 24 and 48 hpf using morphological endpoints. The test was considered to be valid if a minimum of 90% of fish eggs developed normally for the two controls (test material alone and MAS alone). For each test material, the experiment was repeated three times with the controls satisfying the validation criteria (≤ 10% impaired embryos). Indeed, no significant teratogenic effects were observed compared to controls in fish embryos exposed to the proteratogens alone (i.e., without metabolic activation) or the MAS alone. In contrast, the four test materials induced significant abnormalities in fish embryos when co-incubated with animal liver microsomes. For cyclophosphamide, ethanol and thalidomide a concentration-response relationship was shown and the qualitative nature of the malformations was similar between fish embryos and humans. Benzo[a]pyrene was demonstrated to be significantly teratogenic in fish embryos in spite of no concentration-response and unspecific teratogenic fingerprints. We conclude that the application of animal liver microsomes will improve and refine the DarT as a predictive and valuable alternative method to screen teratogenic substances.
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3

Ullrich, Anett. "Langzeitkulturen humaner Hepatozyten als Alternative zur Wirkstofftestung in Tierversuchen." Göttingen Sierke, 2009. http://d-nb.info/993662862/04.

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4

Pritzkow, Sandra [Verfasser]. "In-vitro-Bestimmung der Keimaktivität von Scrapie-assoziiertem Prionprotein : eine Alternative zu Tierversuchen bei Desinfektionsstudien an Prionen / Sandra Pritzkow." Berlin : Freie Universität Berlin, 2011. http://d-nb.info/1025938909/34.

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Lipinski, Alice [Verfasser], Stefan [Gutachter] Wiese, and Matthias [Gutachter] Schmidt. "Transaktivierungsanalyse des TrkB-Rezeptors und sein Einfluss auf das Verhalten von PC12 Zellen : Etablierung eines Zellkulturmodells als Alternative zu Tierversuchen / Alice Lipinski ; Gutachter: Stefan Wiese, Matthias Schmidt ; Fakultät für Biologie und Biotechnologie." Bochum : Ruhr-Universität Bochum, 2021. http://d-nb.info/1239419015/34.

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6

Wächter, Thomas. "Semi-automated Ontology Generation for Biocuration and Semantic Search." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-64838.

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Background: In the life sciences, the amount of literature and experimental data grows at a tremendous rate. In order to effectively access and integrate these data, biomedical ontologies – controlled, hierarchical vocabularies – are being developed. Creating and maintaining such ontologies is a difficult, labour-intensive, manual process. Many computational methods which can support ontology construction have been proposed in the past. However, good, validated systems are largely missing. Motivation: The biocuration community plays a central role in the development of ontologies. Any method that can support their efforts has the potential to have a huge impact in the life sciences. Recently, a number of semantic search engines were created that make use of biomedical ontologies for document retrieval. To transfer the technology to other knowledge domains, suitable ontologies need to be created. One area where ontologies may prove particularly useful is the search for alternative methods to animal testing, an area where comprehensive search is of special interest to determine the availability or unavailability of alternative methods. Results: The Dresden Ontology Generator for Directed Acyclic Graphs (DOG4DAG) developed in this thesis is a system which supports the creation and extension of ontologies by semi-automatically generating terms, definitions, and parent-child relations from text in PubMed, the web, and PDF repositories. The system is seamlessly integrated into OBO-Edit and Protégé, two widely used ontology editors in the life sciences. DOG4DAG generates terms by identifying statistically significant noun-phrases in text. For definitions and parent-child relations it employs pattern-based web searches. Each generation step has been systematically evaluated using manually validated benchmarks. The term generation leads to high quality terms also found in manually created ontologies. Definitions can be retrieved for up to 78% of terms, child ancestor relations for up to 54%. No other validated system exists that achieves comparable results. To improve the search for information on alternative methods to animal testing an ontology has been developed that contains 17,151 terms of which 10% were newly created and 90% were re-used from existing resources. This ontology is the core of Go3R, the first semantic search engine in this field. When a user performs a search query with Go3R, the search engine expands this request using the structure and terminology of the ontology. The machine classification employed in Go3R is capable of distinguishing documents related to alternative methods from those which are not with an F-measure of 90% on a manual benchmark. Approximately 200,000 of the 19 million documents listed in PubMed were identified as relevant, either because a specific term was contained or due to the automatic classification. The Go3R search engine is available on-line under www.Go3R.org.
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Wächter, Thomas. "Semi-automated Ontology Generation for Biocuration and Semantic Search." Doctoral thesis, 2010. https://tud.qucosa.de/id/qucosa%3A25496.

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Background: In the life sciences, the amount of literature and experimental data grows at a tremendous rate. In order to effectively access and integrate these data, biomedical ontologies – controlled, hierarchical vocabularies – are being developed. Creating and maintaining such ontologies is a difficult, labour-intensive, manual process. Many computational methods which can support ontology construction have been proposed in the past. However, good, validated systems are largely missing. Motivation: The biocuration community plays a central role in the development of ontologies. Any method that can support their efforts has the potential to have a huge impact in the life sciences. Recently, a number of semantic search engines were created that make use of biomedical ontologies for document retrieval. To transfer the technology to other knowledge domains, suitable ontologies need to be created. One area where ontologies may prove particularly useful is the search for alternative methods to animal testing, an area where comprehensive search is of special interest to determine the availability or unavailability of alternative methods. Results: The Dresden Ontology Generator for Directed Acyclic Graphs (DOG4DAG) developed in this thesis is a system which supports the creation and extension of ontologies by semi-automatically generating terms, definitions, and parent-child relations from text in PubMed, the web, and PDF repositories. The system is seamlessly integrated into OBO-Edit and Protégé, two widely used ontology editors in the life sciences. DOG4DAG generates terms by identifying statistically significant noun-phrases in text. For definitions and parent-child relations it employs pattern-based web searches. Each generation step has been systematically evaluated using manually validated benchmarks. The term generation leads to high quality terms also found in manually created ontologies. Definitions can be retrieved for up to 78% of terms, child ancestor relations for up to 54%. No other validated system exists that achieves comparable results. To improve the search for information on alternative methods to animal testing an ontology has been developed that contains 17,151 terms of which 10% were newly created and 90% were re-used from existing resources. This ontology is the core of Go3R, the first semantic search engine in this field. When a user performs a search query with Go3R, the search engine expands this request using the structure and terminology of the ontology. The machine classification employed in Go3R is capable of distinguishing documents related to alternative methods from those which are not with an F-measure of 90% on a manual benchmark. Approximately 200,000 of the 19 million documents listed in PubMed were identified as relevant, either because a specific term was contained or due to the automatic classification. The Go3R search engine is available on-line under www.Go3R.org.
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Books on the topic "Alternative zum Tierversuch"

1

Computergestütztes "Molecular modelling": Alternativen zum Tierversuch. Jülich: Forschungszentrum Jülich, 1991.

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2

E, Weber, and Forschungszentrum Jülich. Projektträger Biologie, Energie und Ökologie., eds. Pharmakologische Untersuchungen in vitro: Alternativen zum Tierversuch. Jülich: Forschungszentrum Jülich, Zentralbibliothek, 1990.

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3

Wege zur Bewertung und Anerkennung von Alternativen zum Tierversuch: Vorträge des gleichnamigen bga-Symposiums am 25./26. April 1989 in Berlin. München: MMV Medizin Verlag, 1989.

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Book chapters on the topic "Alternative zum Tierversuch"

1

Zeilinger, K., S. Auth, J. Unger, A. Grebe, L. Mao, M. Petrik, Z. Amalou, K. Appel, and J. C. Gerlach. "Standardisierung eines Hepatozyten- Bioreaktorsystemes für in vitro- Metabolismusstudien als Alternative zum Tierversuch." In Ersatz- und Ergänzungsmethoden zu Tierversuchen, 1–7. Vienna: Springer Vienna, 2000. http://dx.doi.org/10.1007/978-3-7091-6760-1_1.

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Zeilinger, K., J. Unger, S. Auth, A. Grebe, M. Lei, M. Petrick, G. Friedrich, K. Appel, and J. C. Gerlach. "Standardisierung eines Hepatozyten-Bioreaktormodelles für in vitro-Metabolismusstudien als Alternative zum Tierversuch." In Ersatz- und Ergänzungsmethoden zu Tierversuchen, 469. Vienna: Springer Vienna, 2000. http://dx.doi.org/10.1007/978-3-7091-6760-1_113.

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Schenkel, Johannes. "Alternativen zu Tierversuchen." In Versuchstierkunde, 117–23. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-55291-9_9.

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4

Erhard, M. "Dotterantikörper als Alternative zu den Serumantikörpern." In Ersatz- und Ergänzungsmethoden zu Tierversuchen, 314–19. Vienna: Springer Vienna, 1995. http://dx.doi.org/10.1007/978-3-7091-9418-8_45.

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5

Cußler, K. "Tierversuche im Arzneibuch — Möglichkeiten für Alternativen bei Veterinärimpfstoffen." In Ersatz- und Ergänzungsmethoden zu Tierversuchen, 183–87. Vienna: Springer Vienna, 1995. http://dx.doi.org/10.1007/978-3-7091-9418-8_26.

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6

Deiler, S., K. G. Kanz, and L. Schweiberer. "Der Einsatz von Trainingsmodellen in der Notarztausbildung. Eine Alternative zum Tierlabor?" In Ersatz- und Ergänzungsmethoden zu Tierversuchen, 91–95. Vienna: Springer Vienna, 1993. http://dx.doi.org/10.1007/978-3-7091-9307-5_16.

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7

Leenaars, M., C. F. M. Hendriksen, M. A. Koedam, and E. Claassen. "Comparison of alternatives to Freund’s Complete Adjuvant." In Ersatz- und Ergänzungsmethoden zu Tierversuchen, 233–41. Vienna: Springer Vienna, 1997. http://dx.doi.org/10.1007/978-3-7091-6833-2_30.

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Krug, F., C. Bruce Boye, G. Boos, L. V. Klitzing, and H. P. Bruch. "Simulationsmodelle in der gefäßchirurgischen Forschung als Alternative zu Tierexperimenten." In Ersatz- und Ergänzungsmethoden zu Tierversuchen, 360–64. Vienna: Springer Vienna, 2000. http://dx.doi.org/10.1007/978-3-7091-6760-1_48.

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Plietz, M., and R. Rost. "Computergestützte Experimente als Alternative zu Tierversuchen im Physiologischen Praktikum." In Ersatz- und Ergänzungsmethoden zu Tierversuchen, 439–40. Vienna: Springer Vienna, 1997. http://dx.doi.org/10.1007/978-3-7091-6833-2_76.

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van der Valk, J. B. F., and M. D. O. van der Kamp. "The Netherlands Centre Alternatives to Animal Use (NCA)." In Ersatz- und Ergänzungsmethoden zu Tierversuchen, 444. Vienna: Springer Vienna, 1997. http://dx.doi.org/10.1007/978-3-7091-6833-2_80.

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Conference papers on the topic "Alternative zum Tierversuch"

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Jungmann, A., L. Schwärzel, N. Schmoll, F. Seiler, J. Schenk, QT Dinh, R. Bals, PM Lepper, and A. Omlor. "Anwendung eines „in-vitro-mock-circuit“ ECCO2R-Modells als Alternative zu Tierversuchen." In 61. Kongress der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e.V. Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0039-3403230.

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