Relevant bibliographies by topics / Alternatives to animal testing

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Alternatives to animal testing'

Author: Grafiati
Published: 4 June 2021
Last updated: 2 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Alternatives to animal testing.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Alternatives to animal testing"

1

HOGUE, CHERYL, and JEFF JOHNSON. "ANIMAL TESTING ALTERNATIVES." Chemical & Engineering News 85, no. 25 (June 18, 2007): 12. http://dx.doi.org/10.1021/cen-v085n025.p012.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Jackson, Edward M. "Alternatives to Animal Testing." Journal of Toxicology: Cutaneous and Ocular Toxicology 15, no. 1 (January 1996): 29–31. http://dx.doi.org/10.3109/15569529609044445.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Jackson, Edward M. "“Why have Alternatives to Animal Skin Testing Lagged Behind Alternatives to Animal Eye Testing?”." Journal of Toxicology: Cutaneous and Ocular Toxicology 12, no. 2 (January 1993): 83–84. http://dx.doi.org/10.3109/15569529309036251.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Jackson, Edward M. "Why Have Alternatives to Animal Skin Testing Lagged Behind Alternatives to Animal Eye Testing?" Journal of Toxicology: Cutaneous and Ocular Toxicology 15, no. 1 (January 1996): 95–96. http://dx.doi.org/10.3109/15569529609044476.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Hunter, Robert G. "Alternatives to Animal Testing Drive Market." Genetic Engineering & Biotechnology News 34, no. 1 (January 2014): 11. http://dx.doi.org/10.1089/gen.34.01.07.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Doke, Sonali K., and Shashikant C. Dhawale. "Alternatives to animal testing: A review." Saudi Pharmaceutical Journal 23, no. 3 (July 2015): 223–29. http://dx.doi.org/10.1016/j.jsps.2013.11.002.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Griffin, Gilly. "Alternatives in Canada." Alternatives to Laboratory Animals 23, no. 6 (November 1995): 824–26. http://dx.doi.org/10.1177/026119299502300612.

Full text
Abstract:
In Canada, promotion of the Three Rs concept of alternatives occurs largely through the Canadian Council on Animal Care. Institution-based animal care committees are required to conduct an ethical review of all protocols which use animals in research, teaching or testing. Investigators are expected to use animals only when their best efforts to find an alternative have failed. Those using animals are required to employ the most humane methods on the smallest number of animals possible. The Joseph F. Morgan Research Foundation was established to promote the development and use of alternative methods in Canada. The focus of the Foundation has been on the use of alternative methods for testing purposes. However, the Foundation also encourages the acceptance of each of the Three Rs throughout Canadian science. The Foundation is therefore in the process of developing a refinement alternatives programme.
APA, Harvard, Vancouver, ISO, and other styles
8

Cheng, Shujun, Xiaoting Qu, and Yao Qin. "Harmonisation of Animal Testing Alternatives in China." Alternatives to Laboratory Animals 45, no. 6 (December 2017): 333–38. http://dx.doi.org/10.1177/026119291704500603.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Kojima, Hajime. "International cooperation for alternatives to animal testing." Folia Pharmacologica Japonica 138, no. 3 (2011): 103–7. http://dx.doi.org/10.1254/fpj.138.103.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Dolgin, Elie. "Animal testing alternatives come alive in US." Nature Medicine 16, no. 12 (December 2010): 1348. http://dx.doi.org/10.1038/nm1210-1348.

Full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "Alternatives to animal testing"

1

Busquet, François. "Development of a new screening assay to identify proteratogenic compounds using Zebrafish Danio rerio embryo combined with an exogenous mammalian metabolic activation system (mDarT)." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2008. http://nbn-resolving.de/urn:nbn:de:bsz:14-ds-1228302283465-60848.

Full text
Abstract:
The assessment of teratogenic effects of chemicals is generally performed using in vivo teratogenicity assays e.g., in rats or rabbits. Following the 3R principles, the development of alternative methods is encouraged to reduce the number of animal tests. From this perspective, we have developed an in vitro assay (mDarT) using the zebrafish Danio rerio embryo teratogenicity assay (DarT) combined with an exogenous mammalian metabolic activation system (MAS), able to biotransform proteratogenic compounds. Cyclophosphamide, ethanol, benzo[a]pyrene and thalidomide were used as test materials to assess the efficiency of this assay. Briefly, the zebrafish embryos were co-cultured at 2 hpf (hours post fertilization) with the test material at varying concentrations, mammalian liver microsomes from different species and NADPH for 60 min at 32°C under moderate agitation in Tris buffer. The negative control (test material alone) and the MAS control (MAS alone) were incubated in parallel. For each test group, 20 eggs were used for statistical robustness. Afterwards fish embryos were transferred individually into 24-well plates filled with fish medium for 48 hours at 26°C with a 12 hour-light cycle. Teratogenicity was scored after 24 and 48 hpf using morphological endpoints. The test was considered to be valid if a minimum of 90% of fish eggs developed normally for the two controls (test material alone and MAS alone). For each test material, the experiment was repeated three times with the controls satisfying the validation criteria (≤ 10% impaired embryos). Indeed, no significant teratogenic effects were observed compared to controls in fish embryos exposed to the proteratogens alone (i.e., without metabolic activation) or the MAS alone. In contrast, the four test materials induced significant abnormalities in fish embryos when co-incubated with animal liver microsomes. For cyclophosphamide, ethanol and thalidomide a concentration-response relationship was shown and the qualitative nature of the malformations was similar between fish embryos and humans. Benzo[a]pyrene was demonstrated to be significantly teratogenic in fish embryos in spite of no concentration-response and unspecific teratogenic fingerprints. We conclude that the application of animal liver microsomes will improve and refine the DarT as a predictive and valuable alternative method to screen teratogenic substances.
APA, Harvard, Vancouver, ISO, and other styles
2

Li, Zihao. "Power Study on Testing Epidemic Alternatives." FIU Digital Commons, 2013. http://digitalcommons.fiu.edu/etd/820.

Full text
Abstract:
Detecting change points in epidemic models has been studied by many scholars. Yao (1993) summarized five existing test statistics in the literature. Out of those test statistics, it was observed that the likelihood ratio statistic showed its standout power. However, all of the existing test statistics are based on an assumption that population variance is known, which is an unrealistic assumption in practice. To avoid assuming known population variance, a new test statistic for detecting epidemic models is studied in this thesis. The new test statistic is a parameter-free test statistic which is more powerful compared to the existing test statistics. Different sample sizes and lengths of epidemic durations are used for the power comparison purpose. Monte Carlo simulation is used to find the critical values of the new test statistic and to perform the power comparison. Based on the Monte Carlo simulation result, it can be concluded that the sample size and the length of the duration have some effect on the power of the tests. It can also be observed that the new test statistic studied in this thesis has higher power than the existing test statistics do in all of cases.
APA, Harvard, Vancouver, ISO, and other styles
3

Denis, Daniel J. "Null hypothesis significance testing, history, criticisms and alternatives." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ59127.pdf.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Parkinson, Christopher. "The use of cell cultures as an alternative to live animals in acute fish toxicity testing." Thesis, Kingston University, 1988. http://eprints.kingston.ac.uk/20348/.

Full text
Abstract:
The toxicity of various chemicals was investigated in vitro and in vivo in carp ('Cyprinus carpio') and tilapia ('Oreochromis spilurus'). In order to study tilapia in vitro it was necessary to establish and characterise a cell line. A fibroblastic cell line, called TSB cells was derived tilapia brain. A cytotoxicity assay was devised utilising cultures of EPC cells (of carp epithelioma origin) and TSB cells. The effects of the test chemicals were assessed quantitatively by protein assay or lysosomal uptake of Neutral Red dye, and subjectively by light microscopy. The in vivo toxicities of the same chemicals were studied in static 96h LC[sub]50 bioassays. The responses by carp and tilapia to the effects of the chemicals were recorded. In addition, histopathological examination was carried out on a number of tissues of fish employed in the LC[sub]50 tests. From these examinations, further information as to the nature of toxicity caused by each chemical in carp and tilapia was produced. Correlations between in vitro and in vivo acute toxicities were generally good, although the in vitro assays lacked comparable sensitivity. It is therefore not possible at this stage to adequately replace live animals with cell cultures in toxicity testing. However, the results obtained here clearly establish that the use of cell cultures in toxicity assessment programmes could lead to a reduction in the numbers of fish being used. This investigation has also clearly identified the avenues future research has to explore if the use of live fish is to be minimised.
APA, Harvard, Vancouver, ISO, and other styles
5

Sheng, Ru. "A Bayesian analysis of hypothesis testing problems with skewed alternatives." [Milwaukee, Wis.] : e-Publications@Marquette, 2009. http://epublications.marquette.edu/dissertations_mu/23.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Cutting, Christine. "Testing uniformity against rotationally symmetric alternatives on high-dimensional spheres." Doctoral thesis, Universite Libre de Bruxelles, 2020. https://dipot.ulb.ac.be/dspace/bitstream/2013/306900/4/Main.pdf.

Full text
Abstract:
Dans cette thèse, nous nous intéressons au problème de tester en grande dimension l'uniformité sur la sphère-unité $S^{p_n-1}$ (la dimension des observations, $p_n$, dépend de leur nombre, $n$, et être en grande dimension signifie que $p_n$ tend vers l'infini en même temps que $n$). Nous nous restreignons dans un premier temps à des contre-hypothèses ``monotones'' de densité croissante le long d'une direction ${\pmb \theta}_n\in S^{p_n-1}$ et dépendant d'un paramètre de concentration $\kappa_n>0$. Nous commençons par identifier le taux $\kappa_n$ auquel ces contre-hypothèses sont contiguës à l'uniformité ;nous montrons ensuite grâce à des résultats de normalité locale asymptotique, que le test d'uniformité le plus classique, le test de Rayleigh, n'est pas optimal quand ${\pmb \theta}_n$ est connu mais qu'il le devient à $p$ fixé et dans le cas FvML en grande dimension quand ${\pmb \theta}_n$ est inconnu.Dans un second temps, nous considérons des contre-hypothèses ``axiales'', attribuant la même probabilité à des points diamétralement opposés. Elles dépendent aussi d'un paramètre de position ${\pmb \theta}_n\in S^{p_n-1}$ et d'un paramètre de concentration $\kappa_n\in\R$. Le taux de contiguïté s'avère ici plus élevé et suggère un problème plus difficile que dans le cas monotone. En effet, le test de Bingham, le test classique dans le cas axial, n'est pas optimal à ${\pmb \theta}_n$ inconnu et $p$ fixé, et ne détecte pas les contre-hypothèses contiguës en grande dimension. C'est pourquoi nous nous tournons vers des tests basés sur les plus grande et plus petite valeurs propres de la matrice de variance-covariance et nous déterminons leurs distributions asymptotiques sous les contre-hypothèses contiguës à $p$ fixé.Enfin, à l'aide d'un théorème central limite pour martingales, nous montrons que sous certaines conditions et après standardisation, les statistiques de Rayleigh et de Bingham sont asymptotiquement normales sous l'hypothèse d'invariance par rotation des observations. Ce résultat permet non seulement d'identifier le taux auquel le test de Bingham détecte des contre-hypothèses axiales mais aussi celui auquel il détecte des contre-hypothèses monotones.
In this thesis we are interested in testing uniformity in high dimensions on the unit sphere $S^{p_n-1}$ (the dimension of the observations, $p_n$, depends on their number, and high-dimensional data are such that $p_n$ diverges to infinity with $n$).We consider first ``monotone'' alternatives whose density increases along an axis ${\pmb \theta}_n\in S^{p_n-1}$ and depends on a concentration parameter $\kappa_n>0$. We start by identifying the rate at which these alternatives are contiguous to uniformity; then we show thanks to local asymptotic normality results that the most classical test of uniformity, the Rayleigh test, is not optimal when ${\pmb \theta}_n$ is specified but becomes optimal when $p$ is fixed and in the high-dimensional FvML case when ${\pmb \theta}_n$ is unspecified.We consider next ``axial'' alternatives, assigning the same probability to antipodal points. They also depend on a location parameter ${\pmb \theta}_n\in S^{p_n-1}$ and a concentration parameter $\kappa_n\in\R$. The contiguity rate proves to be higher in that case and implies that the problem is more difficult than in the monotone case. Indeed, the Bingham test, the classical test when dealing with axial data, is not optimal when $p$ is fixed and ${\pmb \theta}_n$ is not specified, and is blind to the contiguous alternatives in high dimensions. This is why we turn to tests based on the extreme eigenvalues of the covariance matrix and establish their fixed-$p$ asymptotic distributions under contiguous alternatives.Finally, thanks to a martingale central limit theorem, we show that, under some assumptions and after standardisation, the Rayleigh and Bingham test statistics are asymptotically normal under general rotationally symmetric distributions. It enables us to identify the rate at which the Bingham test detects axial alternatives and also monotone alternatives.
Doctorat en Sciences
info:eu-repo/semantics/nonPublished
APA, Harvard, Vancouver, ISO, and other styles
7

Del, Bufalo Aurelia. "Effets des sensibilisants sur la synthèse de la prostaglandine E2 : Mécanismes et intérêt dans la prédiction de l’allergie de contact." Thesis, Paris, AgroParisTech, 2012. http://www.theses.fr/2012AGPT0003/document.

Full text
Abstract:
Les sensibilisants de contact sont des molécules réactives électrophiles qui ont la capacité de modifier des protéines de la peau pour former un antigène. Au delà de ce mécanisme d'hapténisation, le signal de danger induit par les sensibilisants conduisant à l'activation des cellules dendritiques (DC) est un élément déterminant dans l'induction de cellules T spécifiques de l'haptène. Dans le contexte du 7ième amendement à la directive cosmétique européenne, la mise en place d'une batterie de tests in vitro permettant de prédire le potentiel sensibilisant de molécules est indispensable pour l'industrie cosmétique. Tandis que la plupart des études in vitro étudient les signaux de danger induits par les sensibilisants dans des modèles homéostasiques, nous nous sommes intéressés à l'effet des sensibilisants sur la mise en place d'une réponse inflammatoire. Lorsque la lignée U937 est différenciée avec du PMA et stimulée avec du LPS, les facteurs de transcription NF-κB et Nrf2 sont activés et l'acide arachidonique (AA) est métabolisé au travers de la cascade cPLA2 / COX-2. L'ensemble de ces voies activées conduit à la production par les U937 d'un grand nombre de médiateurs inflammatoires (IL-1β, TNF-α, IL-6, IL-10, IL-8, PGE2, PGD2, TxB2). Dans ce modèle, nous avons analysé l'effet de 6 sensibilisants de potentiels variés (DNCB, PPD, HQ, PG, CIN, EUG) et montré que de façon inattendue, tous les sensibilisants étudiés diminuent significativement et de façon spécifique la production de tous les prostanoïdes et en particulier de PGE2 induite par PMA/LPS. Nous avons de plus démontré que selon les sensibilisants, les cibles de cette inhibition au sein de la cascade métabolique de l'AA diffèrent, même si elles se focalisent la plupart du temps (sauf pour le DNCB) sur l'enzyme COX-2 (inhibition de son expression et/ou de son activité). Pour le DNCB, le mécanisme d'inhibition semble plutôt impliquer sa capacité à réagir fortement avec les groupements résidus thiols, ce qui se traduit en particulier par la déplétion du GSH intracellulaire et engendrerait l'inhibition des synthases dépendantes du GSH pour leurs activités. En parallèle de cette étude mécanistique, nous avons appréhendé la problématique du point de vue statistique et vérifié sur un set plus important et diversifié de molécules (160 molécules) que le paramètre « inhibition de PGE2 » pouvait être un bon test de prédiction de l'HSRC. L'étude statistique a permis de déterminer le modèle prédictif du test PGE2 et de mettre en évidence de bonnes performances (78%) par rapport aux prédictions du LLNA. Au-delà, une certaine complémentarité du test PGE2 avec d'autres tests in vitro (MUSST, Nrf2-HTS) a pu être mise en évidence. En conclusion, au travers de cette étude, nous avons pu mettre en évidence de nouvelles propriétés biochimiques des sensibilisants. Même si la signification biologique de la diminution de PGE2 par les sensibilisants de contact demeure complexe d'interprétation, ce paramètre a permis le développement d'un test qui prédit avec de bonnes performances le caractère sensibilisant de molécules et dont la position au sein d'une batterie prédictive d'évaluation de l'allergie de contact reste à être précisée
Contact sensitizers are defined as reactive molecules (electrophilic) which have the ability to modify skin proteins to form an antigen (hapten). In addition to the haptenation mechanism, danger signals, leading to the activation of dendritic cells, are described to be crucial for the effective induction of an hapten-specific T cell immune response. In the context of the 7th amendment to the Cosmetic Directive, the cosmetic industry is concerned by the challenge of finding non-animal approaches to assess the sensitizing potential of chemicals. While danger signals induced by sensitizers in steady-state conditions have already been analyzed, we chose to investigate the impact of sensitizers on the course of an inflammatory response. For this purpose we used the U937 cell line differentiated with PMA and activated with LPS. In these conditions, cells produce a large amount of inflammatory mediators (IL-β, TNF-α, IL-6, IL-10, IL-8, PGE2, PGD2, TxB2) through the activation of pathways leading to the activation of the transcription factors NF-κB and Nrf2 and through AA metabolism by the cPLA2/COX-2 cascade. Interestingly, we showed that 6 contact sensitizers with various potential (DNCB, PPD, HQ, PG, CIN, EUG) significally and specifically decrease the production of prostanoïds and in particular of PGE2 induced by PMA/LPS. We further demonstrated that there is no unique inhibition profile of the sensitizers even if the majority (except for DNCB) of the effects applies on COX-2 (i.e. inhibition of the expression and/or activity). For DNCB, inhibition mechanism appears to be dependant of its capacity to react with thiols residues and in particular to deplete intracellular glutathione possibly leading to the inactivation of the PG-synthases. In parallel, we assess a statistical analysis on 160 molecules that allow us to define the test parameters (a molecule is a sensitizer if the PGE2 inhibition at 24h is more than 60%) and to calculate the test performance toward LLNA (78%). Moreover we demonstrated that the PGE2 test could be complementary to other already existing in vitro tests like MUSST or Nrf2-HTS. In summary, we add here a new insight into the multiple biochemical effects described so far for sensitizers. Even if the underlying biological relevance remains unclear, the parameter “PGE2 inhibition” is good test for skin sensitization evaluation. Further studies will precise how this parameter could be implemented into an alternative testing strategy for the evaluation of skin sensitization
APA, Harvard, Vancouver, ISO, and other styles
8

Wächter, Thomas. "Semi-automated Ontology Generation for Biocuration and Semantic Search." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-64838.

Full text
Abstract:
Background: In the life sciences, the amount of literature and experimental data grows at a tremendous rate. In order to effectively access and integrate these data, biomedical ontologies – controlled, hierarchical vocabularies – are being developed. Creating and maintaining such ontologies is a difficult, labour-intensive, manual process. Many computational methods which can support ontology construction have been proposed in the past. However, good, validated systems are largely missing. Motivation: The biocuration community plays a central role in the development of ontologies. Any method that can support their efforts has the potential to have a huge impact in the life sciences. Recently, a number of semantic search engines were created that make use of biomedical ontologies for document retrieval. To transfer the technology to other knowledge domains, suitable ontologies need to be created. One area where ontologies may prove particularly useful is the search for alternative methods to animal testing, an area where comprehensive search is of special interest to determine the availability or unavailability of alternative methods. Results: The Dresden Ontology Generator for Directed Acyclic Graphs (DOG4DAG) developed in this thesis is a system which supports the creation and extension of ontologies by semi-automatically generating terms, definitions, and parent-child relations from text in PubMed, the web, and PDF repositories. The system is seamlessly integrated into OBO-Edit and Protégé, two widely used ontology editors in the life sciences. DOG4DAG generates terms by identifying statistically significant noun-phrases in text. For definitions and parent-child relations it employs pattern-based web searches. Each generation step has been systematically evaluated using manually validated benchmarks. The term generation leads to high quality terms also found in manually created ontologies. Definitions can be retrieved for up to 78% of terms, child ancestor relations for up to 54%. No other validated system exists that achieves comparable results. To improve the search for information on alternative methods to animal testing an ontology has been developed that contains 17,151 terms of which 10% were newly created and 90% were re-used from existing resources. This ontology is the core of Go3R, the first semantic search engine in this field. When a user performs a search query with Go3R, the search engine expands this request using the structure and terminology of the ontology. The machine classification employed in Go3R is capable of distinguishing documents related to alternative methods from those which are not with an F-measure of 90% on a manual benchmark. Approximately 200,000 of the 19 million documents listed in PubMed were identified as relevant, either because a specific term was contained or due to the automatic classification. The Go3R search engine is available on-line under www.Go3R.org.
APA, Harvard, Vancouver, ISO, and other styles
9

Touma, Wissam Elias. "Alkali-silica reaction in Portland cement concrete : testing methods and mitigation alternatives /." Digital version accessible at:, 2000. http://wwwlib.umi.com/cr/utexas/main.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Boni, Julia Elisabeth. "Improvements to biorelevant dissolution testing: lyophilized media, buffer alternatives and miniaturized apparatus /." Göttingen : Cuvillier, 2009. http://d-nb.info/996542787/04.

Full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Books on the topic "Alternatives to animal testing"

1

Kojima, Hajime, Troy Seidle, and Horst Spielmann, eds. Alternatives to Animal Testing. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-2447-5.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Hester, R. E., and R. M. Harrison, eds. Alternatives To Animal Testing. Cambridge: Royal Society of Chemistry, 2006. http://dx.doi.org/10.1039/9781847552457.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Reinhardt, Christoph A., ed. Alternatives to Animal Testing. Weinheim, Germany: Wiley-VCH Verlag GmbH, 1994. http://dx.doi.org/10.1002/9783527616053.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Royal Society of Chemistry (Great Britain), ed. Alternatives to animal testing. Cambridge: Royal Society of Chemistry, 2006.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
5

Deborah, Rudacille, and Goldberg Alan M, eds. Animals and alternatives in testing: History, science, and ethics. New York: Mary Ann Liebert, 1994.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
6

Kojima, Hajime. Alternatives to Animal Testing: Proceedings of Asian Congress 2016. Singapore: Springer Nature, 2019.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
7

W, Bradbury J., Andersson M. B, Heisler L, Berlin (Germany : West). Senat., and Stifterverband für die Deutsche Wissenschaft., eds. Sexual selection: Testing the alternatives : report of the Dahlem Workshop on Sexual Selection: Testing the Alternatives, Berlin 1986, August 31-September 5. Chichester: Wiley, 1987.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
8

1949-, Chengelis Christopher P., ed. Acute toxicology testing. 2nd ed. San Diego: Academic Press, 1998.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
9

1949-, Chengelis Christopher P., ed. Acute toxicology testing: Perspectives and horizons. Caldwell, N.J: Telford Press, 1988.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
10

Davies, Jamie A. Replacing animal models: A practical guide to creating and using culture-based biomimetic alternatives. Chichester, West Sussex: John Wiley & Sons, 2012.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Book chapters on the topic "Alternatives to animal testing"

1

Gunatilake, Mangala. "Zebrafish, Danio Rerio as a Replacement Alternative Model Useful in CKDu Experiments." In Alternatives to Animal Testing, 1–7. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-2447-5_1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Uhlrich, Sylvie, Emmanuelle Coppens, Frederic Moysan, Sue Nelson, and Nolwenn Nougarede. "3Rs in Quality Control of Human Vaccines: Opportunities and Barriers." In Alternatives to Animal Testing, 76–82. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-2447-5_10.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Willett, Catherine. "The Use of Adverse Outcome Pathways (AOPs) to Support Chemical Safety Decisions Within the Context of Integrated Approaches to Testing and Assessment (IATA)." In Alternatives to Animal Testing, 83–90. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-2447-5_11.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Kang, Hee Young, and Eui-Bae Jeung. "Alternative Methods for Developmental Toxicity Testing Using Mouse ESCs." In Alternatives to Animal Testing, 105–9. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-2447-5_13.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Murugadas, Anbazhagan, Mohammed Zeeshan, and Mohammad A. Akbarsha. "Futuristic Approach to Alternative Model Organisms: Hydra Stakes Its Claim." In Alternatives to Animal Testing, 110–23. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-2447-5_14.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Ram, Rebecca. "The Lush Prize and Young Researcher Asia Awards 2016." In Alternatives to Animal Testing, 124–28. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-2447-5_15.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Lin, Yu-Chun, Hui-Chun Hsu, Chiu-Hsing Lin, Cheng-Yi Wu, Wannhsin Chen, and Huey-Min Lai. "Testing Method Development and Validation for in Vitro Skin Irritation Testing (SIT) by Using Reconstructed Human Epidermis (RhE) Skin Equivalent - EPiTRI®." In Alternatives to Animal Testing, 8–19. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-2447-5_2.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Setijanti, Herlina B., Eka Rusmawati, Rahmi Fitria, Tuty Erlina, Rina Adriany, and Murtiningsih. "Development the Technique for the Preparation and Characterization of Reconstructed Human Epidermis (RHE)." In Alternatives to Animal Testing, 20–32. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-2447-5_3.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Kurosawa, Tsutomu Miki. "Alternative Research (3Rs) in the World, Asia and Japan." In Alternatives to Animal Testing, 33–36. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-2447-5_4.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Strickland, Judy, Michael W. Paris, David Allen, and Warren Casey. "Approaches to Reducing Animal Use for Acute Toxicity Testing: Retrospective Analyses of Pesticide Data." In Alternatives to Animal Testing, 37–49. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-2447-5_5.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Alternatives to animal testing"

1

Forrest, Stephen, John Paul Sodusta, Brian Herbst, and Steven E. Meyer. "Pendulum Animal Impact Testing." In ASME 2009 International Mechanical Engineering Congress and Exposition. ASMEDC, 2009. http://dx.doi.org/10.1115/imece2009-13057.

Full text
Abstract:
When vehicles collide with large animals, such as cattle, moose, elk or horses, the front seat occupants can be seriously or fatally injured; primarily due to roof deformation. In order to protect the front occupants in these accidents, it is necessary to understand the forces and energy involved in the interaction between the animal and the vehicle roof structure. The authors have developed a pendulum test incorporating an animal dummy to generate similar roof deformation to that experienced in real world animal impact accidents. The energy absorbed by the vehicle roof structure in the accident can then be determined by comparing the accident vehicle roof deformation to the pendulum test vehicle roof deformation. Ultimately, alternative roof structural designs are evaluated to demonstrate that a roof can perform well in this type of accident mode and reduce the risk for serious injuries to the occupants.
APA, Harvard, Vancouver, ISO, and other styles
2

Chen, C., H. Ahlers, and M. Boeniger. "262. Application of Data From Animal Toxicity Testing and Alternative Methods in Assignment of Skin Notations." In AIHce 2004. AIHA, 2004. http://dx.doi.org/10.3320/1.2758194.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Segalova, Polina A., Guanglei Xiong, K. T. Rao, Christopher K. Zarins, and Charles A. Taylor. "Evaluating Design of Abdominal Aortic Aneurysm Endografts in a Patient-Specific Model Using Computational Fluid Dynamics." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53134.

Full text
Abstract:
Design and evaluation of implantable medical devices often relies on benchtop testing using physical models and animal studies. Although both methods are needed, they can be costly to implement and unable to represent patient-specific physiologic conditions. Computer simulations of blood flow in patient-specific anatomies offer an attractive alternative [1].
APA, Harvard, Vancouver, ISO, and other styles
4

Cunningham, Matt, Sarah Howard, Abby Beltrame, Yan Chen, and Mark Smith. "Thrombogenicity Testing for Blood-Contacting Medical Devices in an In Vitro Human Blood-Loop." In 2018 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/dmd2018-6875.

Full text
Abstract:
Thrombogenicity testing continues to be a critical requirement for regulatory approval of blood-contacting medical devices and the ISO guidelines have recently been updates [1]. This new guideline ascribes value to both in vivo and in vitro testing including both the non-anticoagulated venous implant (NAVI) model, and the new methods for in vitro testing. One challenge with the animal-blood-based in vitro assays that have been validated and used for submissions is that they still may not accurately translate to clinical safety or predict the risk for thrombogenic potential in humans. We have previously described a model using minimally heparinized ovine blood and are continuing to improve the overall methodology [2,3]. In addition, we have transferred these methods to a human blood assay which therefore has enhanced potential for prediction of clinical risk. As with the ovine model, the key characteristics of a successful in vitro method include fresh blood, low levels of anticoagulation, flow conditions and minimization of air/blood interfaces. This human model integrates freshly harvested human blood containing minimal levels of heparin with variable flow from a unidirectional peristaltic pump and unlike many of the human blood assays, it can accommodate larger devices and higher flow rates than previously described [1,4]. Control materials which were optimized in the ovine model were also used to reproducibly elicit positive and negative thrombogenic responses. We feel that this model can be used for validation of the ovine model with cross comparisons of a number of legally marketed comparator devices. Alternatively, if the human blood methodology can be streamlined and performed cost effectively on a regular and basis, this assay could supplant the current ovine model and allow a highly predictive preclinical test for thrombogenicity of devices.
APA, Harvard, Vancouver, ISO, and other styles
5

Gernand, Jeremy M. "Limitations on the Reliability of In Vitro Predictive Toxicity Models to Predict Pulmonary Toxicity in Rodents." In ASME 2016 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/imece2016-67151.

Full text
Abstract:
Given the rapidly proliferating varieties of nanomaterials and ongoing concerns that these novel materials may pose emerging occupational and environmental risks, combined with the possibility that each variety might pose a different unique risk due to the unique combination of material properties, researchers and regulators have been searching for methods to identify hazards and prioritize materials for further testing. While several screening tests and toxic risk models have been proposed, most have relied on cellular-level in vitro data. This foundation enables answers to be developed quickly for any material, but it is yet unclear how this information may translate to more realistic exposure scenarios in people or other more complex animals. A quantitative evaluation of these models or at least the inputs variables to these models in the context of rodent or human health outcomes is necessary before their classifications may be believed for the purposes of risk prioritization. This paper presents the results of a machine learning enabled meta-analysis of animal studies attempting to use significant descriptors from in vitro nanomaterial risk models to predict the relative toxicity of nanomaterials following pulmonary exposures in rodents. A series of highly non-linear random forest models (each made up of an ensemble of 1,000 regression tree models) were created to assess the maximum possible information value of the in vitro risk models and related methods of describing nanomaterial variants and their toxicity in rat and mouse experiments. The variety of chemical descriptors or quantitative chemical property measurements such as bond strength, surface charge, and dissolution potential, while important in describing observed differences with in vitro experiments, proved to provide little indication of the relative magnitude of inflammation in rodents (explained variance amounted to less than 32%). Important factors in predicting rodent pulmonary inflammation such as primary particle size and chemical type demonstrate that there are critical differences between these two toxicity assays that cannot be captured by a series of in vitro tests alone. Predictive models relying primarily on these descriptors alone explained more than 62% of the variance of the short term in vivo toxicity results. This means that existing proposed nanomaterial toxicity screening methods are inadequate as they currently stand, and either the community must be content with the slower and more expensive animal testing to evaluate nanomaterial risks, or further conceptual development of improved alternative in vitro screening methodologies is necessary before manufacturers and regulators can rely on them to promote safer use of nanotechnology.
APA, Harvard, Vancouver, ISO, and other styles
6

Klingshirn, Christopher D., Matthew J. DeWitt, Rich Striebich, David Anneken, Linda Shafer, Edwin Corporan, Matt Wagner, and Dean Brigalli. "Hydroprocessed Renewable Jet Fuel Evaluation, Performance, and Emissions in a T-63 Turbine Engine." In ASME 2011 Turbo Expo: Turbine Technical Conference and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/gt2011-46572.

Full text
Abstract:
Due to potential beneficial environmental impacts and increased supply availability, alternative fuels derived from renewable resources are evolving on the forefront as unconventional substitutes for fossil fuel. Focus is being given to the evaluation and certification of Hydroprocessed Renewable Jet (HRJ), a fuel produced from animal fat and/or plant oils (triglycerides) by hydroprocessing, as the next potential synthetic aviation fuel. Extensive efforts have recently been performed at the Air Force Research Laboratory (AFRL) at Wright Patterson Air Force Base (WPAFB) to evaluate the potential of two HRJ fuels produced from camelina and tallow feedstocks. These have included characterization of the fuel chemical and physical fuel characteristics, and Fit-for-Purpose properties (FFP). The present effort describes general combustion performance and emission propensity of a T63-A-700 Allison turbine engine operated on the HRJs and 50/50 (by volume) HRJ/JP-8 fuel blends relative to a specification JP-8. In addition, engine and emission testing with a blend of the tallow-derived HRJ and 16% bio-derived aromatic components was completed. Fundamental engine performance characterization allows for determination of the suitability of potential synthetic fuels while quantitation of gaseous and particulate matter emissions provides an assessment of the potential environmental impact compared to current petroleum-derived fuels. In addition, an extended 150 hour endurance test was performed using a 50/50 blend of tallow-derived HRJ with JP-8 to evaluate the long-term operation of the engine with the synthetic fuel blend. This paper discusses the laboratory testing performed to characterize HRJs and results from the basic engine operability and emissions studies of the alternative fuel blends.
APA, Harvard, Vancouver, ISO, and other styles
7

Tanner, Matthew, Peter Stryker, and Indranil Brahma. "Assessment of the Feasibility of Biodiesel Blends for Small Commercial Engines." In ASME 2012 Internal Combustion Engine Division Fall Technical Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/icef2012-92159.

Full text
Abstract:
Petroleum supply and environmental issues have increased interest in renewable low polluting alternative fuels. Published test results generally indicate decreased pollution with similar power output from internal combustion engines burning alternative fuels. More specifically, diesel engines burning biodiesel derived from plant oils and animal fats, not only reduce harmful exhaust emissions, but are renewable and environmentally friendly. A literature review found little previous research with biodiesel in small commercial diesel engines. This paper presents the research that was conducted to study the effect of biodiesel/diesel fuel blends on engine performance and emissions for a Yanmar L100 EE (7.1 kW) engine. This is a standard commercial grade diesel engine used for small equipment such as generators. Independent engine dynamometer and emissions testing were performed to validate the lower emission claims and assess the feasibility of alternative fuels. A testing apparatus capable of making relevant measurements was designed, built and used to perform this study. Fuel blends used included B2, B20, B40, B60, B80, and B100 where the biodiesel component of the blend was a commercial product. An analysis of the fuel showed large percentages of linoleic acid, palmitic acid and stearic acid which is typical for a blend of soybean oil and beef tallow. Test were performed at a constant torque (95 % of the continuously rated value) and variable engine speeds. Test results included calculated values of BMEP, BSFC, thermal efficiency, air mass flow rate, air fuel ratio, corrected NOx, energy lost to exhaust, and heat rejection, and measured values of unburned hydrocarbons, carbon monoxide, and carbon dioxide. Results indicate an increase in thermal efficiency compared to standard diesel and significant reductions of unburned hydrocarbons and carbon monoxide at all engine speeds. Brake specific fuel consumption increased with increasing percent biodiesel consistent with the decreased energy content of blended fuel. Significantly, there were small but consistent reductions in corrected NOx for all blends at all speeds. We posit possible explanations for these results, which are contrary to the published results for larger engines which show an increase in NOx for biodiesel blends.
APA, Harvard, Vancouver, ISO, and other styles
8

Kintis, Marinos, Mike Papadakis, and Nicos Malevris. "Evaluating Mutation Testing Alternatives: A Collateral Experiment." In 2010 17th Asia Pacific Software Engineering Conference (APSEC). IEEE, 2010. http://dx.doi.org/10.1109/apsec.2010.42.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Homer, John, Ashley Whitson, Bruce Whisner, Jeff Yonkey, and Dave Yantek. "Explosion Testing of Relief Valves for Underground Refuge Alternatives." In ASME 2019 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/imece2019-10592.

Full text
Abstract:
Abstract Federal regulations require refuge alternatives (RAs) to be installed in underground coal mines. RAs provide miners safe shelter from life-threatening environments during a mine emergency when escape is not possible. Built-in-place (BIP) RAs require ventilation systems that supply breathable air to occupants. Relief valves provide critical functions to the ventilation system by limiting pressure within the RA, allowing ventilation air to exit while preventing contamination ingress, and protecting occupants from external pressure due to mine explosions. As such, relief valves for BIP RAs must be developed and tested to ensure pressure relief, adequate airflow, and the ability to withstand a 103-kPa (15-psi) blast overpressure with a duration of 0.2 seconds. The National Institute for Occupational Safety and Health (NIOSH) has published research on relief valve opening pressures and airflow rates. However, the ability of RA relief valves to withstand a survivable mine explosion must be demonstrated. As such, NIOSH researchers tested the ability of RA relief valves to withstand overpressure representative of a survivable mine explosion. For this, seven relief valves were subjected to 103-kPa (15-psi) target overpressure waveforms, produced using methane-air explosions within a fixed-volume enclosure. All seven relief valves survived the overpressure testing, maintained normal performance, and did not incur any critical component deformation. One instance of valve leakage was observed during the tests. This paper presents the methodology and results of testing the ability of RA relief valves to withstand a survivable mine explosion. Information in this publication can be used for evaluating relief valve design and determining parameters critical to their ability to reliably withstand a survivable mine explosion and protect RA occupants. Research presented in this paper is applicable to testing and improving RA designs for underground coal mines, and could also be extended to similar applications and industries involving explosion testing.
APA, Harvard, Vancouver, ISO, and other styles
10

Bartel, S., J. Domin, J. Karczewski, M. Kciuk, L. Kozielski, Z. Pilch, and P. Wyciślok. "TESTING THE STRENGTH OF LASER-BONDED ANIMAL INTESTINES." In Engineering Mechanics 2020. Institute of Thermomechanics of the Czech Academy of Sciences, Prague, 2020. http://dx.doi.org/10.21495/5896-3-066.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Reports on the topic "Alternatives to animal testing"

1

Hollis, Rebecca Vincent, William Kirk Hollis, Jaqueline Hargraves, Elena Atencio, Brendon Andrew Parsons, Helen Marie Milenski, and Lisa Meyers. Cheesecloth Alternatives Testing. Office of Scientific and Technical Information (OSTI), May 2018. http://dx.doi.org/10.2172/1438351.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Keithly, Janet S. Testing Experimental Compounds against Leishmaniasis in Laboratory Animal Model Systems. Fort Belvoir, VA: Defense Technical Information Center, April 1988. http://dx.doi.org/10.21236/ada196657.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Lee Nelson. Alternatives Analysis for the Resumption of Transient Testing Program. Office of Scientific and Technical Information (OSTI), November 2013. http://dx.doi.org/10.2172/1111017.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

WOLFF, J. J. Alternatives Generation and Analysis for Lower Knuckle Ultrasonic Testing Technology. Office of Scientific and Technical Information (OSTI), February 2001. http://dx.doi.org/10.2172/806022.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Jorgensen, Shelly. Design and testing of microfabricated surgical tools for large animal probe insertion. Office of Scientific and Technical Information (OSTI), August 2016. http://dx.doi.org/10.2172/1305826.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Wilmarth, W. R. DuoliteTM GT-73 Resin Testing in Support of the Salt Disposition Alternatives. Office of Scientific and Technical Information (OSTI), December 1998. http://dx.doi.org/10.2172/4873.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Gasper, K. A. Cost benefit and risk assessment for selected tank waste process testing alternatives. Office of Scientific and Technical Information (OSTI), May 1995. http://dx.doi.org/10.2172/80977.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Friedman, G. H. Office of Inspector General audit of alternatives to testing at the Tonopah Test Range. Office of Scientific and Technical Information (OSTI), March 1998. http://dx.doi.org/10.2172/584987.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Gallogly, Hilary. Comparative Testing of Hemostatic Dressing in a Large Animal Model (Sus Scorofa) with Severe hepatic Injuries. Fort Belvoir, VA: Defense Technical Information Center, December 2013. http://dx.doi.org/10.21236/ada608134.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

HERTING DL. HANFORD MEDIUM-LOW CURIE WASTE PRETREATMENT ALTERNATIVES PROJECT FRACTIONAL CRYSTALLIZATION PILOT SCALE TESTING FINAL REPORT. Office of Scientific and Technical Information (OSTI), September 2008. http://dx.doi.org/10.2172/938408.

Full text
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'Alternatives to animal testing' for particular source types:
Journal articles Dissertations / Theses Books
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography