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Relevant bibliographies by topics / Alveolar mechanics / Dissertations / Theses

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Dissertations / Theses on the topic 'Alveolar mechanics'

Author: Grafiati

Published: 4 June 2021

Last updated: 19 February 2022

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1

Liu, Hui. "The application of alveolar microscope on alveolar mechanics of ventilator-induced lung injury." [S.l. : s.n.], 2008. http://nbn-resolving.de/urn:nbn:de:bsz:25-opus-61847.

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2

Dash, Shari Anne Ahmed El. "Estudo tomográfico de pressões de colapso alveolar e níveis isogravitacionais em pulmões de pacientes com SDRA e LPA." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/5/5159/tde-25062009-113611/.

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Estudo clínico prospectivo, em 11 pacientes com SARA ou LPA, avaliando o comportamento regional da densidade do tecido pulmonar e do colapso alveolar ao longo dos três eixos do espaço. Foram realizadas tomografias seriadas, após manobra de recrutamento inicial e após níveis de PEEP progressivamente decrescentes. Regressão linear múltipla (R2=0.83) mostrou importante gradiente no eixo gravitacional (p<0.001) e não no sentido céfalo-caudal (p<0.001), nem da direita para a esquerda (p<0.05). Isto corrobora o conceito do pulmão líquido, em que a resultante das pressões exercidas pelo diafragma, es

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3

Namati, Eman, and eman@namati com. "Pre-Clinical Multi-Modal Imaging for Assessment of Pulmonary Structure, Function and Pathology." Flinders University. Computer Science, Engineering and Mathematics, 2008. http://catalogue.flinders.edu.au./local/adt/public/adt-SFU20081013.044657.

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In this thesis, we describe several imaging techniques specifically designed and developed for the assessment of pulmonary structure, function and pathology. We then describe the application of this technology within appropriate biological systems, including the identification, tracking and assessment of lung tumors in a mouse model of lung cancer. The design and development of a Large Image Microscope Array (LIMA), an integrated whole organ serial sectioning and imaging system, is described with emphasis on whole lung tissue. This system provides a means for acquiring 3D pathology of fixed w

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4

Rolle, Trenicka. "Lung Alveolar and Tissue Analysis Under Mechanical Ventilation." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3398.

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Mechanical ventilation has been a major therapy used by physicians in support of surgery as well as for treating patients with reduced lung function. Despite its many positive outcomes and ability to maintain life, in many cases, it has also led to increased injury of the lungs, further exacerbating the diseased state. Numerous studies have investigated the effects of long term ventilation with respect to lungs, however, the connection between the global deformation of the whole organ and the strains reaching the alveolar walls remains unclear. The walls of lung alveoli also called the alveola

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5

Liao, Pinhu. "Mechanotransduction in alveolar epithelial cells subjected to mechanical strain." Thesis, Imperial College London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.479153.

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6

Chen, Shanze [Verfasser], and Silke [Akademischer Betreuer] Meiners. "Molecular mechanism of alveolar macrophage polarization and cell communication with alveolar epithelial cell / Shanze Chen. Betreuer: Silke Meiners." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2015. http://d-nb.info/1080479074/34.

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7

McKechnie, Stuart R. "The roles of hyperoxia and mechanical deformation in alveolar epithelial injury and repair." Thesis, University of Edinburgh, 2008. http://hdl.handle.net/1842/2691.

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The alveolar epithelium is a key functional component of the air-blood barrier in the lung. Comprised of two morphologically distinct cell types, alveolar epithelial type I (ATI) and type II (ATII) cells, effective repair of the alveolar epithelial barrier following injury appears to be an important determinant of clinical outcome. The prevailing view suggests this repair is achieved by the proliferation of ATII cells and the transdifferentiation of ATII cells into ATI cells. Supplemental oxygen and mechanical ventilation are key therapeutic interventions in the supportive treatment of respira

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8

Fois, Georgio [Verfasser]. "Response of alveolar type II pneumocytes to mechanical stimulation / Giorgio Fois." Ulm : Universität Ulm. Medizinische Fakultät, 2012. http://d-nb.info/1019167831/34.

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9

Dickie, A. John. "Mechanisms by which endotoxin-stimulated alveolar macrophages impair lung epithelial sodium transport." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0025/MQ51593.pdf.

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10

Mossadeq, Sayeed. "Kinetics and mechanisms of accumulation for liposomal ciprofloxacin into rat alveolar macrophages." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/501.

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The kinetics and mechanism of accumulation for liposomal ciprofloxacin (Lipo-CPFX) into the rat alveolar macrophage NR8383 cells were studied in vitro, in comparison to unformulated ciprofloxacin (CPFX). Upon incubation with CPFX or Lipo-CPFX, cellular drug accumulation was determined from the cell lysates or efflux was from the extracellular media by fluorescence-HPLC. The accumulation for Lipo-CPFX reached the asymptotic values at ≥ 2 hours, which was a result of uptake and efflux. The uptake appeared to be due to liposomes, mediated via cellular energy-independent mechanism like lipid fusio

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11

Rummel, Sebastian. "Mechanisms of alveolar protein clearance in isolated rabbit lungs : role of clathrin and caveolae mediated endocytosis of albumin by the alveolar epithelium /." Giessen : VVB Laufersweiler, 2007. http://d-nb.info/988285827/04.

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12

Freire, Filho Francisco Wagner Vasconcelos. "Estudo comparativo dimensional e da resistencia mecanica de dois sitemas nacionais de distratores osteogenicos alveolares justa-osseos." [s.n.], 2003. http://repositorio.unicamp.br/jspui/handle/REPOSIP/289441.

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Orientador: Jose Ricardo de Albergaria Barbosa<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-03T23:42:34Z (GMT). No. of bitstreams: 1 FreireFilho_FranciscoWagnerVasconcelos_D.pdf: 1185958 bytes, checksum: d471fe34fa012fb2c3725a04c776609d (MD5) Previous issue date: 2004<br>Resumo: O objetivo deste trabalho foi comparar dois sistemas de distratores osteogênicos alveolares justa-ósseos de 9mm de abertura máxima de fabricação nacional. Foram analisadas duas marcas comerciais (Grupo I e Grupo II), através das

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13

Rummel, Sebastian [Verfasser]. "Mechanisms of alveolar protein clearance in isolated rabbit lungs : role of clathrin- and caveolae-mediated endocytosis of albumin by the alveolar epithelium / eingereicht von Sebastian Rummel." Giessen : VVB Laufersweiler, 2008. http://d-nb.info/988773570/34.

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14

Gavara, i. Casas Núria. "Contractile response of alveolar epithelial cells to biochemical or mechanical stimulation probed by traction microscopy." Doctoral thesis, Universitat de Barcelona, 2007. http://hdl.handle.net/10803/1146.

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THESIS SUMMARY:<br/><br/>GENERAL AIM<br/><br/>The general aim of this thesis was to study the generation of contractile force by human alveolar epithelial cells in culture in response to biochemical or mechanical stimuli using traction microscopy.<br/><br/>SPECIFIC AIMS<br/><br/>1. To implement a traction microscopy setup to measure the contractile force generated by human alveolar epithelial cells in culture.<br/>1.1. To implement and validate a software to determine the deformation field induced by adhered cells on the elastic substrate, following previously described algorithms.<br/>1.2. To

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15

Armstrong, Lynne. "Tumour necrosis factor-alpha regulation in human alveolar macrophages : mechanisms in health and acute lung injury." Thesis, University of Bath, 1995. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307115.

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16

Higuita-Castro, Natalia. "Micro/Nano Scale Modeling of Cellular injury and Inflammation in the Alveolar Microenvironment during Mechanical Ventilation." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1385516912.

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17

Usmani, Shariq M. [Verfasser]. "Calcium signaling mechanisms in alveolar epithelial cells : Effects of physiological and patho-physiological perturbations / Shariq M. Usmani." Konstanz : Bibliothek der Universität Konstanz, 2011. http://d-nb.info/1019938889/34.

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18

Kramer, Barbara [Verfasser]. "Collagen vascular diseases associated with interstitial lung diseases : analysis of alveolar epithelial cellular stress mechanisms / Barbara Kramer." Gießen : Universitätsbibliothek, 2017. http://d-nb.info/1127506692/34.

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19

Ambrósio, Aline Magalhães. "Estudo da influência das manobras de recrutamento alveolar sobre a mecânica, a ventilação e o parênquima pulmonar durante lesão aguda promovida pela instilação de ácido clorídrico: estudo experimental em porcos." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/10/10137/tde-29092006-201943/.

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Diversas estratégias de ventilação mecânica que estabelecem limites na pressão e volume intratorácicas têm sido propostas para pacientes com síndrome de angustia respiratória aguda (SARA). Estas recomendações são baseadas na observação de que a ventilação mecânica com volume corrente excessivo ou pressão positiva expiratória final (PEEP) insuficiente pode ocasionar lesões pulmonares graves, decorrentes de superdistensão de unidades alveolares. O objetivo do atual estudo foi aplicar manobras de recrutamento alveolar e PEEP em pulmões submetidos à lesão pulmonar aguda (LPA) através da administra

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20

Wang, Huiyan. "Toxicity and signaling mechanisms underlying interactions of Stachybotrys chartarum toxins with lung macrophages." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1319487821.

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21

Faron, Matthew Leon. "Examining mechanisms of virulence gene regulation and the early host interactions in Francisella tularenisis." Diss., University of Iowa, 2014. https://ir.uiowa.edu/etd/1595.

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Francisella tularensis is a facultative intracellular pathogen and is the etiological agent of tularemia. One key aspect to the success of Francisella as a pathogen is ability of the organism to establish infection with a low inoculum, as few as 10 colony forming units (cfu). Essential to this process is the Francisella pathogenicity island (FPI). Several studies have been performed to understand how the FPI is regulated; however, the working model is not complete, as the signals important for regulation are unknown. Additionally, the mechanisms of the proteins MigR, TrmE, and CphA, which are

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22

Nahle, Sara. "Réponse macrophagique aux nanomatériaux carbonés : effets de leur caractéristiques physiques et chimiques sur le transcriptome Carbon-based nanomaterials induce inflammation and autophagy in rat alveolar macrophages Single wall and multiwall carbon nanotubes induce different toxicological responses in rat alveolar macrophages Gene expression profiling of alveolar macrophages exposed to non-functionalized, anionic or cationic multi-walled carbon nanotubes shows three different mechanisms of toxicity Cytotoxicity and global transcriptional responses induced by zinc oxide nanoparticles NM 110 in PMA-differentiated THP-1 cells Protein and lipid homeostasis altered in rat macrophages after exposure to metallic oxide nanoparticles." Thesis, Université de Lorraine, 2019. http://www.theses.fr/2019LORR0142.

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Les nanomatériaux carbonés (NMC) sont très utilisés dans le monde industriel et leurs applications, nombreuses, sont en plein développement. L’absence de réglementation pour leur préparation et leur emploi fait qu’il est nécessaire comme pour tous les nano-objets, de déterminer le risque qu’une exposition fait courir à l’Homme et d’adapter la législation en conséquence. Une meilleure connaissance de leur potentiel toxique est donc nécessaire. Les difficultés de plus en plus grandes pour utiliser les modèles animaux, rend nécessaire le développement d’études avec des lignées cellulaires au sein

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23

Lanças, Tatiana. "Responsividade do tecido pulmonar periférico de pacientes com doença pulmonar obstrutiva crônica." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/5/5144/tde-08032010-155914/.

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Mais de 60% dos pacientes com Doença Pulmonar Obstrutiva Crônica (DPOC) podem apresentar hiper-responsividade brônquica. Entretanto, não se sabe se, além das vias aéreas, o tecido pulmonar periférico também apresenta uma resposta exagerada a um agonista na DPOC. No presente estudo foi investigado o comportamento mecânico in vitro e as alterações estruturais e inflamatórias do tecido pulmonar periférico de 10 pacientes com DPOC comparados com 10 controles não fumantes. Foram realizadas medidas de resistência (R) e elastância (E) de fatias pulmonares em situação basal e após desafio com Acetilco

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24

Avena-Barthelemy, Anne. "Comportement a long terme de materiaux composites immerges a grande profondeur." Paris, ENMP, 1987. http://www.theses.fr/1987ENMP0049.

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Etude du vieillissement de polymeres renforces ou non de fibres de verre ou de mousses syntactiques immerges dans l'eau sous des pressions de 0 a 300 bars. Adsorption d'eau, proprietes mecaniques, eclatement des microspheres dans les mesures syntactiques

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25

Liu, Hui [Verfasser]. "The application of alveolar microscope on alveolar mechanics of ventilator-induced lung injury / vorgelegt von Hui Liu." 2009. http://d-nb.info/992111439/34.

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26

Tsang, Melanie Elizabeth. "Molecular mechanisms of LPS detection by human alveolar epithelial cells." 2005. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=362440&T=F.

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27

Kuo, Tsung-Chen, and 郭俊成. "Studies on the Toxicological Mechanisms of Methylmercury in Rat Alveolar Macrophages." Thesis, 1997. http://ndltd.ncl.edu.tw/handle/16312312456143551201.

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博士<br>國立臺灣大學<br>毒理學研究所<br>85<br>Mercury compounds of both natural and industrial origin are wide- spread environmental pollutants. Organic mercury compounds have been involved in large-scale poisoning episodes. Human exposure to mercurials occurs in the production of batteries, in chloralkali plants, gold mining, dentistry, and the use of grain fungicides. Although the primary targets of mercury compounds have been identified as the nervous systems and the kidney, toxic effec

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28

Chang, Te-Su, and 張特書. "Mechanical and Thermal Effects on Alveolar Bone by Using Simplified Drilling Sequence." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/369te5.

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碩士<br>國立臺北科技大學<br>製造科技研究所<br>105<br>Simplified drilling sequence which reducing the number of drills used in alveolar bone drilling in dental implant surgery has become a trend for the past few years. It is hoped that the simplified drilling sequence can reduce the surgery time but on the other hand the surgical difficulty and bone damage may also arise. In this study, the mechanical and thermal effects of three simplified sequences were investigated by using finite element analysis combining failure theory and heat transfer module, and the effects of different drill parameters were also inves

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29

Chen, De Yuan, and 陳德元. "The mechanism of cytotoxic effect of aflatoxin B1 on swine alveolar macrophages." Thesis, 1995. http://ndltd.ncl.edu.tw/handle/68418342440549605964.

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30

Scherbart, Agnes Martha [Verfasser]. "Mechanisms and consequences of particle uptake in alveolar macrophages / vorgelegt von Agnes Martha Scherbart." 2011. http://d-nb.info/101287852X/34.

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31

Hsiao, Yu Chun, and 蕭宇君. "Mechanisms underlying TNF-a-induced cytosolic phospholipase A2 expression in human alveolar epithelial cells." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/61557363805703977784.

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碩士<br>長庚大學<br>生物醫學研究所<br>98<br>Human pulmonary alveolar epithelial cells play an important role in the proliferation, migration, and inflammatory processes in the respiratory system. Several factors have been shown to trigger the mechanisms for the pathologenesis of airway diseases including asthma and chronic obstructive pulmonary disease (COPD). Although the factors concerning about the increased incidence of inflammatory responses are well known, however, the intracellular signaling pathways involved in the expression of inflammatory proteins are not completely recognized. Elevated levels o

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32

Korpi-Steiner, Nichole LaRhette. "Mechanisms of cytokine elaboration by human alveolar macrophages and bronchial epithelial cells following rhinovirus challenge." 2006. http://www.library.wisc.edu/databases/connect/dissertations.html.

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33

Cho, Rou Ling, and 卓若羚. "Mechanisms Underlying Lipopolysaccharide Induced Inter-Cellular Adhesion Molecule-1 Expression in Human Pulmonary Alveolar Epithelial Cells." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/75392927840317412406.

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碩士<br>長庚大學<br>生物醫學研究所<br>100<br>Respiratory problems such as asthma and chronic obstructive pulmonary disease (COPD) had been concerned issue of human airway diseases. Lipopolysaccharide (LPS), a key component of the outer membranes of Gram-negative bacteria, plays an important role in the induction of adhesion molecules expression and reactive oxygen species (ROS) generation in airway inflammatory diseases. However, the mechanisms by which up-regulation of intercellular adhesion molecule-1 (ICAM-1) induced by LPS may contribute to inflammatory responses or exert as a host defense in respirato

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34

Hsu, Chun Hao, and 許峻豪. "Mechanisms of sphingosine 1-phosphate-induced intercellular adhesion molecule-1 expression in human pulmonary alveolar epithelial cells." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/26577587528000109277.

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碩士<br>長庚大學<br>生物醫學研究所<br>101<br>Human pulmonary alveolar epithelial cells play an important role in the proliferation, migration, and inflammatory processes in the respiratory system. Several factors have been implicated to trigger the mechanisms for the pathologenesis of airway diseases including asthma and chronic obstructive pulmonary disease (COPD). Human pulmonary alveolar epithelial cells (HPAEpiCs) play an important role in airway inflammatory processes. Several studies demonstrate that expression of adhesive molecules on the cell surface of epithelial cells plays a critical role in the

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35

Chen, Yi Wen, and 陳薏雯. "The mechanisms and anti-inflammatory effects of Kaempferol induced HO-1 expression in human pulmonary alveolar epithelial cells." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/9askth.

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36

CHEN, HSIAO-MEI, and 陳筱玫. "Mechanisms Underlying Adiponectin–mediated Expression of Cytosolic Phospholipase A2 and Cyclooxygenase-2 in Human Pulmonary Alveolar Epithelial Cells." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/22447606319406163983.

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碩士<br>輔仁大學<br>基礎醫學研究所碩士班<br>102<br>Adiponectin is one of adipocyte-derived hormones. Regarding to reports, adiponectin has pro-inflammatory or anti-inflammatory effects in different organs. But in lung system, what the role of adiponectin is still not known. On the other hand, lung inflammation companied occurrence of various acute or chronic lung diseases, including chronic obstructive pulmonary disease, emphysema and idiopathic pulmonary fibrosis, acute respiratory distress syndrome and obstructive apnea. It is found that several genes such as cPLA2 and COX-2 express and cooperate mediating

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37

Wu, Ming Yen, and 吳明諺. "Mechanisms of heat-killed Staphylococcus aureus-induced vascular cell adhesion molecule-1 expression in human pulmonary alveolar epithelial cells." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/19976734201622663641.

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碩士<br>長庚大學<br>生物醫學研究所<br>99<br>Staphlococcus aureus (S. aureus), the common Gram-positive bacteria, causes a wide range of human inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD). These inflammatory responses are mediated by complex interactions between both circulating polymorphonuclear cells (PMNs) and the vascular endothelium. Several studies have indicated that expression of adhesive molecules on the cell surface of epithelial cells plays a critical role in these inflammatory responses. Although S. aureus has been shown to induce ICAM-1 or VCAM-1 expres

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Yeh, Yi Cheng, and 葉怡成. "Mechanisms underlying mevastatin-induced heme oxygenase-1 expression and its anti-inflammatory effects in human pulmonary alveolar epithelial cells." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/29053723126283653161.

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39

Cho, Rou Ling, and 卓若羚. "Mechanisms underlying rosiglitazone-induced heme oxygenase-1 expression and its anti-inflammatory effects in human pulmonary alveolar epithelial cells." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/xtt5ma.

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40

Konrad, Christian. "Molecular analysis of insulin signaling mechanisms in Echinococcus multilocularis and their role in the host-parasite interaction in the alveolar echinococcosis." Doctoral thesis, 2007. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-22636.

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The insulin receptor ortholog EmIR of the fox-tapeworm Echinococcus multilocularis displays significant structural homology to the human insulin receptor (HIR) and has been suggested to be involved in insulin sensing mechanisms of the parasite’s metacestode larval stage. In the present work, the effects of host insulin on Echinococcus metacestode vesicles and the proposed interaction between EmIR and mammalian insulin have been studied using biochemical and cell-biological approaches. Human insulin, exogenously added to in vitro cultivated parasite larvae, (i) significantly stimulated parasite

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41

Benchimol, Maxime. "Complicações pós e intra-operatórias na anestesia de bloqueio regional do nervo alveolar inferior." Master's thesis, 2021. http://hdl.handle.net/10284/9644.

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Introdução: Esta revisão narrativa examina artigos de particular interesse sobre o tema: complicações anestésicas do nervo alveolar inferior. Objetivos: O objetivo desta revisão narrativa é determinar o que pode levar a complicações anestésicas do nervo alveolar inferior, o seu tratamento e prevenção. Materiais e Métodos: As buscas foram realizadas nos websites SCIELO, B-ON e PUB MED, utilizando as seguintes palavras-chave: "anasthesia, complications alveolar inferior”, com o objetivo de angariar e debater o máximo de informação sobre este tema. Resultados e Conclusões: Os resulta

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42

Durbin, Adam. "Studies on Signal Transduction Mechanisms in Rhabdomyosarcoma." Thesis, 2010. http://hdl.handle.net/1807/24739.

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Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma of childhood, with two predominant histologic subtypes: embryonal and alveolar. These histologies display distinct clinical courses, and despite refinements in dose and duration of multimodality therapy, the 5-year overall survival of patients diagnosed with metastatic RMS remains <30%. Thus, there is an urgent need to define novel targets for therapeutic intervention. Interrogation of cancer cell signal transduction pathways that regulate the pathogenic behaviours of tumor cells has been successful in defining targets in numerous t

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43

Konrad, Christian [Verfasser]. "Molecular analysis of insulin signaling mechanisms in Echinococcus multilocularis and their role in the host parasite interaction in the alveolar echinococcosis / vorgelegt von: Christian Konrad." 2007. http://d-nb.info/984834710/34.

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44

Chuang, Chi-Yuan, and 莊淇源. "STUDY OF ACUTE LUNG INJURY: MOLECULAR MECHANISMS OF LIPOPOLYSACCHARIDE-INDUCED APOPTOTIC INSULTS AND REGULATION OF surfactant protein GENE EXPRESSION IN HUMAN ALVEOLAR EPITHELIAL TYPE II CELLS." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/03097245032120426995.

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博士<br>臺北醫學大學<br>臨床醫學研究所<br>99<br>Lipopolysaccharide (LPS), a Gram-negative bacterial outer membrane component, is one of the major causes of septic shock with acute lung injury. Pulmonary alveolar epithelial type II cells have highly specialized functions for synthesizing and secreting surfactant proteins (SPs) to participate in the physiological and pathophysiological regulation of sepsis-induced acute lung injury. Alterations in the levels of surfactant components in the lungs during inflammation are quite complex. Toll-like receptors (TLRs) that play important roles in innate immunity can t

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45

Tan, Ju Jing. "Mechanosensitive ATP release in the lungs." Thesis, 2019. http://hdl.handle.net/1866/24849.

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L’ATP est bien connue pour son rôle de transporteur d'énergie à l’intérieur des cellules, mais en dehors de la cellule, elle agit en tant que molécule de signalisation extracellulaire. En se liant aux récepteurs purinergiques, l’ATP extracellulaire amorce la signalisation purinergique afin de réguler certains processus physiologiques et pathophysiologiques. Dans les poumons, l’ATP stimule la sécrétion de surfactant et promeut la clairance mucociliaire. Compte tenu du rôle critique de l’ATP extracellulaire dans les poumons, il est important de comprendre le mécanisme du relargage d’ATP cellulai

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Tabbaa, Chalabi Rajaa. "Effets des nanoparticules manufacturées sur les cellules pulmonaires humaines." Thèse, 2015. http://hdl.handle.net/1866/13674.

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La détection et la caractérisation des nanoparticules manufacturées (NPM) est l’une des premières étapes pour contrôler et diminuer leurs risques potentiels sur la santé humaine et l’environnement. Différents systèmes d’échantillonnage dans l’air existent pour l’évaluation d’une exposition aux NPM. Cependant, ils ne mesurent pas le risque potentiel de cette exposition à la santé humaine ni les mécanismes cellulaires qui en seraient responsables. Nos objectifs de recherche sont 1) Évaluer les effets de différents types de nanoparticules sur des cellules pulmonaires humaines et 2) Identifier de

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