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1

Corriveau, Roderick A., Walter J. Koroshetz, Jordan T. Gladman, et al. "Alzheimer's Disease–Related Dementias Summit 2016: National research priorities." Neurology 89, no. 23 (2017): 2381–91. http://dx.doi.org/10.1212/wnl.0000000000004717.

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Goal 1 of the National Plan to Address Alzheimer’s Disease is to prevent and effectively treat Alzheimer disease and Alzheimer disease–related dementias by 2025. To help inform the research agenda toward achieving this goal, the NIH hosts periodic summits that set and refine relevant research priorities for the subsequent 5 to 10 years. This proceedings article summarizes the 2016 Alzheimer's Disease–Related Dementias Summit, including discussion of scientific progress, challenges, and opportunities in major areas of dementia research, including mixed-etiology dementias, Lewy body dementia, fr
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2

Sianturi, Aditya Gloria Monalisa. "Stadium, Diagnosis, dan Tatalaksana Penyakit Alzheimer." Majalah Kesehatan Indonesia 2, no. 2 (2021): 39–44. http://dx.doi.org/10.47679/makein.202132.

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Dementia is a general term for loss of memory that can occur along with behavioral or psychological symptoms in patients. The first cause of dementia patients is Alzheimer's disease. Alzheimer’s disease is a brain degenerative disease and the most common cause of dementia. In Alzheimer’s disease, there are three development stages, which is stage 1, stage 2, and stage 3 with different clinical symptoms at each stage. There are several clinical criteria for establishing a definitive diagnosis of Alzheimer’s disease and also support examinations have to be carried out. Until now, Alzheimer’s tre
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3

Nurbaiti, Nurbaiti, Shinta Gunawati Sutoro, Eny Supriyaningsih, Sri Wiwik Wiyanti, and Imas Maesaroh. "Edukasi untuk Deteksi Dini dan Perawatan Lansia dengan Alzheimer di Masa Pandemi Covid-19." Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) 6, no. 7 (2023): 2887–95. http://dx.doi.org/10.33024/jkpm.v6i7.10093.

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ABSTRAK Poltekkes Kemenkes Jakarta II melaksanakan kegiatan edukasi kesehatan lansia. Penduduk usia lanjut dengan kondisi demensia Alzheimer membutuhkan perhatian khusus. Jumlah penduduk lansia di Indonesia yang kian bertambah menjadi tantangan bagi keluarga-keluarga Indonesia. Kegiatan edukasi dilakukan secara online dalam bentuk workshop untuk memperkenalkan kasus demensia Alzheimer, cara merawat pasiennya dan mendeteksi gejala-gejalanya. Peserta adalah warga kompleks Depsos, para mahasiswa dan masyarakat umum. Tujuan kegiatan ini untuk meningkatkan pengetahuan dan keterampilan peserta mende
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4

Copeland, J. R. M., Cherie McCracken, M. E. Dewey, et al. "Undifferentiated dementia, Alzheimer's disease and vascular dementia: Age- and gender-related incidence in Liverpool." British Journal of Psychiatry 175, no. 5 (1999): 433–38. http://dx.doi.org/10.1192/bjp.175.5.433.

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BackgroundDoes incidence of dementia follow the age pattern of prevalence? Is gender a risk factor? Do patterns of incidence differ between dementias?AimsTo assess age-specific incidence rates of undifferentiated dementias, Alzheimer's disease and vascular dementia.Method5222 individuals aged $65 years, were interviewed using the Geriatric Mental State/History and Aetiology Schedule. The AGECAT package was used to identify cases at three interviewing waves at two-year intervals. Diagnoses were made using ICD −10 Research Criteria and validated against neurological and psychological examination
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5

Jones, R. W. "Dementia." Scottish Medical Journal 42, no. 5 (1997): 151–53. http://dx.doi.org/10.1177/003693309704200512.

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Dementia in general and Alzheimer's disease in particular represent conditions where new findings are being made rapidly. Some of these developments will lead to progress of increasing clinical value to patients and their carers. This review will begin with some general points about dementia before considering current developments in Alzheimer's disease and other specific dementias in more detail.
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6

Rockwood, Kenneth. "Mixed Dementia: Alzheimer's and Cerebrovascular Disease." International Psychogeriatrics 15, S1 (2003): 39–46. http://dx.doi.org/10.1017/s1041610203008949.

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“Mixed dementia” is traditionally defined as Alzheimer's disease with cerebrovascular disease (CVD). Because the risks of both neurodegenerative dementias and cerebrovascular disease increase with age, the mixed dementias are likely the most common. In practice, patients with mixed dementia are diagnosed by one of two routes: Either they have evidence of a neurodegenerative dementia and CVD at the outset, or, they have a classical neurodegenerative presentation but are found to have ischemic lesions by neuroimaging. These facts have implications for the development of evidence-based diagnostic
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7

Zanni, Guido, and Jeannette Wick. "Differentiating Dementias in Long-Term Care Patients." Consultant Pharmacist 22, no. 1 (2007): 14–28. http://dx.doi.org/10.4140/tcp.n.2007.14.

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Many long-term care residents are diagnosed with dementia, but dementia appears in many forms. Alzheimer's disease, the most common, is typified by a slow onset and relentless progression to complete incapacitation. Vascular dementia usually appears somewhat abruptly, is associated with vascular comorbidities, and has an unpredictable progression pattern. Lewy body dementia shares features of both Alzheimer's and Parkinson's disease; its hallmarks include fluctuating cognitive performance, visual hallucinations, and extrapyramidal motor symptoms. Frontotemporal dementias are associated less wi
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8

Appel, Jason, Elizabeth Potter, Qian Shen, et al. "A Comparative Analysis of Structural Brain MRI in the Diagnosis of Alzheimer’s Disease." Behavioural Neurology 21, no. 1-2 (2009): 13–19. http://dx.doi.org/10.1155/2009/103123.

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Dementia is a debilitating and life-altering disease which leads to both memory impairment and decline of normal executive functioning. While causes of dementia are numerous and varied, the leading cause among patients 60 years and older is Alzheimer’s disease. The gold standard for Alzheimer’s diagnosis remains histological identification of amyloid plaques and neurofibrillary tangles within the medial temporal lobe, more specifically the entorhinal cortex and hippocampus. Although no definitive cure for Alzheimer's disease currently exists, there are treatments targeted at preserving cogniti
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9

Custodio, Nilton, Rosa Montesinos, David Lira, Eder Herrera-Pérez, Yadira Bardales, and Lucía Valeriano-Lorenzo. "Mixed dementia: A review of the evidence." Dementia & Neuropsychologia 11, no. 4 (2017): 364–70. http://dx.doi.org/10.1590/1980-57642016dn11-040005.

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ABSTRACT. Mixed dementia is the coexistence of Alzheimer's disease and cerebrovascular disease (CVD) in the same demented patient. Currently, its diagnosis and treatment remains a challenge for practitioners. To provide an overview of the epidemiology, pathogenesis, natural history, diagnosis, and therapy of Mixed Vascular-Alzheimer Dementia (MVAD). The literature was reviewed for articles published between 1990-2016 by using the keywords linked to MVAD. Neuropathological studies indicate that MVAD is a very common pathological finding in the elderly with a prevalence about of 22%. The distinc
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10

Duduk, S. L., and E. G. Koroleva. "THE CASE OF THE SUPERVISION OF PATIENT SUFFERRING MIXED DEMENTIA WITH ALZHEIMER’S DISEASE." Health and Ecology Issues, no. 4 (December 28, 2009): 149–53. http://dx.doi.org/10.51523/2708-6011.2009-6-4-29.

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The article is presented the supervision of the authors of case mixed (atypical) dementia with Alzheimer's disease. The evaluation of patient is carried out with using modern functional, neurointrascopic and psychometric methods of diagnostics. This research detected as Alzheimer’s nature of disease, so and vascular disturbance, that lead to clinical picture of mixed dementia with Alzheimer's disease.
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11

Rimmer, Elizabeth. "Alzheimer's Disease International." International Psychiatry 3, no. 4 (2006): 22–23. http://dx.doi.org/10.1192/s1749367600004999.

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Alzheimer's Disease International (ADI) is the international federation of 75 Alzheimer associations throughout the world and is in official relations with the World Health Organization. ADI was established to raise awareness about dementia, strengthen Alzheimer associations and provide a platform for the exchange of knowledge with the ultimate goal of improving the quality of life of people with dementia and their families.
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12

Tatsiana, Goluubeva, and Dakukina Tatsiana. "Morbidity and disability in dementia in Belarus for 2016-2023." Endocrinology & Metabolism International Journal 13, no. 1 (2025): 5–10. https://doi.org/10.15406/emij.2025.13.00362.

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Dementia states lead to severe medical and social consequences. Most researchers consider Alzheimer's disease to be the most frequent cause of cognitive impairment in elderly people, the second place is occupied by vascular dementia. In the Republic of Belarus, vascular dementia has the largest share in the structure of morbidity of dementia of various genesis among different age groups. The aim of this study was to investigate the epidemiology of dementias in the Republic of Belarus, including dementia with Alzheimer's disease and vascular dementia, characterization of morbidity and disabilit
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Bourin, Michel. "Vascular Dementia: Definitions, Origins, Symptoms, Diagnosis and Treatments." SAR Journal of Psychiatry and Neuroscience 4, no. 01 (2023): 1–4. http://dx.doi.org/10.36346/sarjpn.2023.v04i01.001.

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Vascular dementia corresponding to intellectual degradation significant enough to disrupt daily life, attributed to cerebral lesions of vascular origin. They are the second cause of dementia after Alzheimer's disease in the defeated countries. Their diagnosis is made difficult, on the one hand by the diversity of lesions potentially responsible for cognitive disorders and on the other hand by their frequent association with Alzheimer's disease. No treatment, other than preventive treatment, has been validated in vascular dementia. Several concepts have attempted or are attempting to characteri
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14

Cummings, Jeffrey L. "Neuropsychiatric Assessment and Intervention in Alzheimer's Disease." International Psychogeriatrics 8, S1 (1996): 25–30. http://dx.doi.org/10.1017/s1041610296003043.

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Dementia is a major public health problem in the United States and the world, requiring the expenditure of enormous economic and human resources. Dementia is common in the elderly, and, as the size of the aged population increases, the number of dementia victims will rise. Many dementias are fatal, producing the gradual erosion of intellectual abilities and eventual death of the patient. Demands made on family members and caregivers of dementia patients are extraordinary and often result in their emotional and financial exhaustion. Although basic science efforts are devoted to finding a cure f
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15

Krsteska, Roza. "Risk factors for dementia of the Alzheimer and vascular type." Medical review 62, no. 5-6 (2009): 201–6. http://dx.doi.org/10.2298/mpns0906201k.

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The current study was aimed at examining the risk factors in 30 patients with Alzheimer's dementia and 30 patients with vascular dementia. The reports of the caregivers and the medical documentation were used to estimate the risk factors. The condition for the patients to enter this study was the age above 60 years. The results showed that the average age in the patients with dementia of the Alzheimer type was statistically significantly higher than in the patients with vascular dementia (p<0.0043), which is the confirmation that the most potential risk factor for Alzheimer's disease is agi
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16

Holroyd, Suzanne. "Hallucinations and Delusions in Dementia." International Psychogeriatrics 12, S1 (2000): 113–17. http://dx.doi.org/10.1017/s1041610200006876.

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Hallucinations and delusions have been described in all types of dementia, including vascular dementia, Lewy body dementia, and dementia associated with Parkinson's disease. They have been recognized in Alzheimer's disease (AD) since the illness was first described (Alzheimer, 1957).
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17

Nabalamba, Alice, and Scott B. Patten. "Prevalence of Mental Disorders in a Canadian Household Population with Dementia." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 37, no. 2 (2010): 186–94. http://dx.doi.org/10.1017/s0317167100009914.

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Background:Medical and mental health comorbidity in Alzheimer's disease and other dementias presents difficult challenges for health service delivery. However, existing studies have been conducted in clinical samples and may not be informative for planning community services. The Canadian Community Health Survey (CCHS) provides an opportunity to characterize associations between dementias and mental and physical comorbidity in a household population aged 55 and over.Methods:Data were obtained from the 2005 CCHS-cycle 3.1. Weighted estimates for mood and anxiety disorders and other characterist
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18

Hemangkorn, Nicha, Pamonphon Phummai, and Patranan Punyacharoen. "Effects of Essential Oils and Aromatic Plants on Alzheimer’s Disease and Dementia." International Journal of Science and Healthcare Research 6, no. 3 (2021): 350–58. http://dx.doi.org/10.52403/ijshr.20210760.

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The primary objective of this research was to investigate how beneficial essential oils and aromatic plants are at curing Alzheimer’s disease and dementia. Alzheimer’s Disease (AD) is known to be one of the most incurable prevalent diseases in the elderly. Agitation, cognitive impairments, communication difficulty, irritability, and confusion may advance in AD patients. Even though the behavioral causes contributing to the disease have not yet been discovered, aggregation of tau and amyloid proteins is found in the brain of patients with Alzheimer’s. With numerous experiments conducted on thes
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19

Liu, Yue, Daniel K. Chan, John D. Crawford, Perminder S. Sachdev, and Nady Braidy. "The Contribution of Cerebral Vascular Neuropathology to Mild Stage of Alzheimer’s Dementia Using the NACC Database." Current Alzheimer Research 17, no. 13 (2021): 1167–76. http://dx.doi.org/10.2174/1567205018666210212160902.

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Background: The interaction between cerebral vessel disease (CVD) pathology and Alzheimer’s disease (AD) pathology in the development of dementia is controversial. We examined the association of cerebral vascular neuropathology and cerebrovascular risk factors with the mild stage of Alzheimer's dementia and cognitive function. Methods: This cross-sectional study included men and women aged 60 years or over who had yearly clinical assessments and had agreed to brain autopsy at the time of death, and who contributed to data stored at the National Alzheimer's Coordinating Center (NACC) in the USA
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20

Kirk, Andrew. "Target Symptoms and Outcome Measures: Cognition." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 34, S1 (2007): S42—S46. http://dx.doi.org/10.1017/s0317167100005552.

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The Cognitive section of the Alzheimer's Disease Assessment Scale (ADAS-Cog) remains the most widely used cognitive measure in dementia trials although it does not assess attention, executive function, or agnosia. Designed for use in Alzheimer's disease (AD), it may not be ideal in assessing patients with other diagnoses. The ADAS-Cog differentiates between AD patients, patients with Mild Cognitive Impairment, and normal controls. It has been used in trials of drugs for vascular and mixed dementia and dementia with Lewy bodies. It is not clear that the ADAS-Cog is adequate for assessing cognit
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Kaban, Irfan Kurnia, and Yudha Haryono. "Late Onset Alzheimer Dementia in Patient with Genotype E3/E4: A Case Report." International Journal of Research and Review 8, no. 11 (2021): 282–85. http://dx.doi.org/10.52403/ijrr.20211136.

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ackground: Alzheimer's dementia (AD) is a neurodegenerative disorder and there is progressive cognitive impairment, functional deficits and behavioral changes. This neurodegenerative disease process is classically characterized by two pathological features: amyloid- β plaque deposition and neurofibrillary tangle of tau hyperphosphorylation. The most established genetic risk factor for late-onset Alzheimer Disease is the APOE gene allele 4. We will report a case of late-onset Alzheimer's Dementia with genotype E3/E4. Case: A 70-years-old woman patient, complained by her family that she often fo
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Lawrence, Broxmeyer MD. "Dr. Oskar Fischer's Curious Little Alzheimer's Germ." Current Opinions in Neurological Science 1, no. 3 (2017): 160–78. https://doi.org/10.5281/zenodo.1026775.

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Alois Alzheimer might have mentioned plaques and tangles in a single short paper on pre-senile dementia in 1907 but it was the co-discover of Alzheimer’s disease, Oskar Fischer, who in that same year far more extensively reported neuritic plaque in 12 cases of senile dementia, a condition which he and many others refused to differentiate from Alzheimer’s “pre-senile” dementia. Fischer, Alzheimer’s great rival, speculated that for the most part these plaques, found only in senile demented patients, caused their dementia. Moreover, Fischer felt such cerebral plaque to be the result of an infecti
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23

Engelhardt, Eliasz, and Marleide da Mota Gomes. "Alzheimer's 100th anniversary of death and his contribution to a better understanding of Senile dementia." Arquivos de Neuro-Psiquiatria 73, no. 2 (2015): 159–62. http://dx.doi.org/10.1590/0004-282x20140207.

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Initially the trajectory of the historical forerunners and conceptions of senile dementia are briefly presented, being highlighted the name of Alois Alzheimer who provided clinical and neuropathological indicators to differentiate a group of patients with Senile dementia. Alzheimer's examination of Auguste D’s case, studied by him with Bielschowsky’s silver impregnation technique, permitted to identify a pathological marker, the intraneuronal neurofibrillary tangles, characterizing a new disease later named after him by Kraepelin – Alzheimer’s disease. Over the time this disorder became one of
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Park, Sang A. "P172: A preliminary study for potential protective role of anti-oxidative stress markers for cognitive impairment: glutathione and glutathione reductase." International Psychogeriatrics 35, S1 (2023): 184. http://dx.doi.org/10.1017/s1041610223003277.

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Objective:We aimed to study the relationship between glutathione (GSH), a key molecule of the anti-oxidant defense system in the blood, and glutathione reductase (GR), which reduces oxidized GSSG to GSH and maintains redox balance, with the prevalence of Alzheimer’s dementia and cognitive decline.Methods:20 with normal cognition and 20 with Alzheimer's dementia who completed the 3rd f/u clinical evaluation over 6 years were selected by matching age and gender. Plasma glutathione (GSH) and glutathione reductase (GR) concentrations were independent variables. Clinical diagnosis and neurocognitiv
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Rinanda, Tiara Disti, Aldo Lovely Arief Suyoso, and Hendro Margono. "Application of Machine Learning for Dementia Classification through MRI Images using Vertex AI on Google Cloud Services." Building of Informatics, Technology and Science (BITS) 6, no. 3 (2024): 2054–62. https://doi.org/10.47065/bits.v6i3.6040.

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Alzheimer's dementia remains a serious global health challenge, particularly in resource-limited countries where early and accurate diagnosis is crucial to reducing morbidity and mortality rates. Despite advances in medical imaging and diagnostic tools, early detection of Alzheimer’s remains a complex and resource-intensive task for healthcare systems worldwide. This study leverages the power of machine learning, specifically Convolutional Neural Networks (CNN), to develop a reliable model for detecting the severity of dementia using brain MRI images. The dataset used consists of four main cat
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Lindsay, Joan, and Lori Anderson. "Dementia / Alzheimer's Disease." BMC Women's Health 4, Suppl 1 (2004): S20. http://dx.doi.org/10.1186/1472-6874-4-s1-s20.

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27

Kumar, Ajeet. "A REVIEW ON SESBANIA GRANDIFLORA ITS EFFECT ON THE TREATMENT OF DEMENTIA AND NEURO DISEASE AND OTHER DISEASES." YMER Digital 21, no. 04 (2022): 128–49. http://dx.doi.org/10.37896/ymer21.04/13.

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One of the most often used folk medicines is Sesbania grandiflora, better known as the Agati or Hummingbird tree. Anemia, bacterial infections, TB, and other illnesses can be treated with the plant's pharmacological properties. Agati's anticancer and hepatoprotective properties are attributable to the presence of phytochemical ingredients. Sesbania grandiflora's therapeutic characteristics are the topic of this article. Normal psychological functioning and behavioural patterns are disrupted by dementia. One to four percent of the world's population over the age of 65 is affected by dementia, w
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McGuire, Lisa. "BUILDING OUR LARGEST DEMENTIA INFRASTRUCTURE FOR ALZHEIMER'S ACT: POLICIES ADVANCING HEALTHY AGING." Innovation in Aging 6, Supplement_1 (2022): 179–80. http://dx.doi.org/10.1093/geroni/igac059.719.

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Abstract While public health experts cannot yet say how to prevent Alzheimer’s disease and related dementias (ADRD), emerging science indicates that ADRD may be slowed through risk reduction strategies, early diagnosis, and better education and training of front-line health care professionals. Recognizing these scientific advances, the National Plan to Address Alzheimer’s Disease: 2021 Update added a new goal, Goal 6, to the 10-year-old plan emphasizing risk reduction and healthy aging: Accelerate Action to Promote Healthy Aging and Reduce Risk Factors for Alzheimer’s Disease and Related Demen
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Tan, Lynnette Pei Lin, Nathan Herrmann, Brian J. Mainland, and Kenneth Shulman. "Can clock drawing differentiate Alzheimer's disease from other dementias?" International Psychogeriatrics 27, no. 10 (2015): 1649–60. http://dx.doi.org/10.1017/s1041610215000939.

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ABSTRACTBackground:Studies have shown the clock-drawing test (CDT) to be a useful screening test that differentiates between normal, elderly populations, and those diagnosed with dementia. However, the results of studies which have looked at the utility of the CDT to help differentiate Alzheimer's disease (AD) from other dementias have been conflicting. The purpose of this study was to explore the utility of the CDT in discriminating between patients with AD and other types of dementia.Methods:A review was conducted using MEDLINE, PsycINFO, and Embase. Search terms included clock drawing or CL
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Meynen, Gerben, Heleen Van Stralen, Jan H. Smit, Wouter Kamphorst, Dick F. Swaab, and Witte J. G. Hoogendijk. "Relation between neuritic plaques and depressive state in Alzheimer's disease." Acta Neuropsychiatrica 22, no. 1 (2010): 14–20. http://dx.doi.org/10.1111/j.1601-5215.2009.00423.x.

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Meynen G, Van Stralen H, Smit JH, Kamphorst W, Swaab DF, Hoogendijk WJG. Relation between neuritic plaques and depressive state in Alzheimer's disease.Background:To investigate for the first time in a prospective study the relationship between depressive state and the neuropathological hallmarks of Alzheimer's disease, using a scale for depressive symptoms in dementia, while controlling for clinical severity of dementia.Method:Within the framework of a prospective longitudinal study of depression in Alzheimer's disease, patients with dementia underwent a clinical evaluation every six months du
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Lautenschlager, Nicola T., and Ralph N. Martins. "Common versus uncommon causes of dementia." International Psychogeriatrics 17, s1 (2005): S27—S34. http://dx.doi.org/10.1017/s1041610205002000.

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When patients present with a dementia syndrome at a young age, the experienced clinician will automatically include uncommon dementias in the diagnostic considerations, as familial uncommon dementias due to genetic mutations frequently present as early-onset dementias. This paper highlights why uncommon dementias due to genetic mutations, although marginal in terms of prevalence numbers in the total population, are of significance in the quest to unravel the underlying cause of common dementias such as Alzheimer's disease (AD), dementia with Lewy bodies (DLB), frontotemporal dementias (FTD) an
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Whitehouse, Peter J., Marian B. Patterson, Milton E. Strauss, et al. "Hallucinations." International Psychogeriatrics 8, S3 (1997): 387–92. http://dx.doi.org/10.1017/s1041610297003694.

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Studies conducted at our Alzheimer Center in Cleveland, Ohio, along with those of other investigators, have documented that visual hallucinations occur with sufficient frequency in Alzheimer's disease and related dementias to warrant further investigation of their meaning and implications. The largest data set in which frequency of hallucinations among persons with Alzheimer's disease has been examined comes from a collaboration among the National Institute of Aging Alzheimer's Disease Cooperative Study (ADCS), the Consortium to Establish a Registry for Alzheimer's Disease (CERAD), and the Cas
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Gonçalves, Vitor, Cátia Vaz, Célia Novais, et al. "Digital technologies and Alzheimer’s from the perspective of formal caregivers using an action research methodology." Arts & Humanities Open Access Journal 6, no. 1 (2024): 51–54. http://dx.doi.org/10.15406/ahoaj.2024.06.00221.

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Alzheimer's dementia leads to a progressive decline in individual's cognitive ability with interference in daily living activities. Applying cognitive stimulation in the early stages is an added value in delaying cognitive decline. In this process, the use of digital technologies may contribute to avoiding, in a first phase, the use of drugs and delaying the institutionalization of Alzheimer's patients. Thus, the general objective was conducted to identify their perceptions on the use of new digital technologies in the cognitive stimulation of Alzheimer's patients with formal caregivers. To th
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Mohr, Erich, Denise Walker, Christopher Randolph, Margaret Sampson, and Tilak Mendis. "Utility of Clinical Trial Batteries in the Measurement of Alzheimer's and Huntington's Dementia." International Psychogeriatrics 8, no. 3 (1996): 397–411. http://dx.doi.org/10.1017/s1041610296002761.

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Tests used as outcome measures in clinical trials of antidementia agents are not typically employed as part of diagnostic evaluations, and little information exists as to the sensitivity of these tests in terms of either differentiating demented patients from normal individuals or in distinguishing dementias of various types and etiologies. Sensitivity to mild dementia and sensitivity to impairment of various neuropsychological domains are, however, prerequisites for valid use of an instrument as an outcome measure in this context. The present study was undertaken to directly compare six diffe
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Martins, Leonardo Tafarello, Ivan Abdalla Teixeira, Jerson Laks, and Valeska Marinho. "Recognizing Late Onset Frontotemporal Dementia with the DAPHNE scale: A case report." Dementia & Neuropsychologia 12, no. 1 (2018): 75–79. http://dx.doi.org/10.1590/1980-57642018dn12-010011.

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ABSTRACT Frontotemporal dementias are classically described as early onset dementias with personality and behavioral changes, however, late onset forms can also be found. Considering the paucity of information about late onset behavioral variant frontotemporal dementia and its challenging diagnosis, we present a case report of an 85-year-old woman with behavioral changes and slow progression to dementia who was first diagnosed as having bipolar disorder and then Alzheimer's disease. The Daphne scale provided a structured means to improve clinical diagnosis, also supported by characteristic fea
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Salardini, Arash. "Interpretation of Biomarker Data in Diagnosis of Primary Dementias." Seminars in Neurology 39, no. 02 (2019): 200–212. http://dx.doi.org/10.1055/s-0039-1683380.

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AbstractIn the last few years, an improved understanding of dementia biomarkers has significantly increased the diagnostic accuracy for dementias. The National Institutes of Health Biomarkers Definitions Working Group defines a biomarker as “a characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention.” In the field of dementia, a biomarker is a biological measure pointing to a specific dementing pathology. Dementia biomarkers may also serve as surrogates for disease pr
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Singh, Atar, Abhay Paliwal, and V. S. Pal. "Comparative study of electroencephalography changes in dementia." International Journal of Research in Medical Sciences 7, no. 8 (2019): 2970. http://dx.doi.org/10.18203/2320-6012.ijrms20193379.

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Background: Dementia affected about 46 million people in 2015and this number will roughly triple within the next 40 years. In 2011 Alzheimer's Disease International argue that dementia has become one of the most urgent health and social care challenges of the 21st century and its potential effect on economies around the world is attracting global attention. Predicting dementia in the early stages would be essential for better treatment before significant brain damage occurs. Current difficulty is the lack of specific biomarkers. In some previous studies electroencephalography (EEG) have shown
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Johansson, Alf, and Lars Gustafson. "Psychiatric Symptoms in Patients With Dementia Treated in a Psychogeriatric Day Hospital." International Psychogeriatrics 8, no. 4 (1996): 645–58. http://dx.doi.org/10.1017/s1041610296002955.

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Sixty-five consecutive patients with dementia, treated at a psychogeriatric day hospital, were studied regarding prevalence of psychiatric symptoms. The clinical diagnoses were dementia of the Alzheimer type (n = 19), vascular dementia (n = 27), mixed Alzheimer's disease and vascular dementia (n = 13), vascular dementia of frontal type (n = 2), and other diseases (n = 4). Mean age at referral was 75.6 ± 6.6 years and the average treatment time was 21 ± 14 months. About 90% of the patients showed one or several significant psychiatric symptoms during the course of dementia. Most common were del
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Förstl, Hans, Alistair Burns, Phil Luthert, Nigel Cairns, and Raymond Levy. "The Lewy-Body Variant of Alzheimer's Disease." British Journal of Psychiatry 162, no. 3 (1993): 385–92. http://dx.doi.org/10.1192/bjp.162.3.385.

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At post-mortem, Lewy bodies (LBs) were found in the brainstem and neocortex of eight out of 65 patients who had been collected during a prospective long-term study on clinically diagnosed Alzheimer’s disease. All eight patients had accompanying Alzheimer pathology which was less severe than in a sample of eight age and sex-matched patients from the same study with neuropathologically verified Alzheimer's disease. Parkinsonian features were more common in patients with LBs. There were no particular differences in duration of illness, severity of cognitive impairment, presence of hallucinations,
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40

Britton, Maggie. "From DemenTia to DemenCia: Way More Than a Single Letter." Innovation in Aging 5, Supplement_1 (2021): 461–62. http://dx.doi.org/10.1093/geroni/igab046.1785.

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Abstract Hispanic or Latino/a/x/e (H/L) individuals are at 1.5x risk for Alzheimer’s Disease and Related Dementias (ADRD) compared to non-H/L White individuals. Although H/L individuals make up roughly 18% of the U.S. population, they are vastly underrepresented in ADRD research. For example, less than 9% of individuals in the National Alzheimer's Coordinating Center (NACC) data set are H/L. Collaborative efforts like the ECHAR Network are working to increase the representation of H/L individuals in ADRD research across the U.S. A non-exhaustive list of barriers to H/L participation include li
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Davis, Laura, Zarina Karim, and Tom Dening. "Diagnostic, management and nursing challenges of less common dementias: Frontotemporal dementia, alcohol-related dementia, HIV dementia and prion diseases." British Journal of Neuroscience Nursing 18, no. 1 (2022): 26–37. http://dx.doi.org/10.12968/bjnn.2022.18.1.26.

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Background: Most cases of dementia are due to Alzheimer's disease or vascular dementia, but attention on these disorders means that other important causes of dementia may be relatively neglected. About 10–15% of people with dementia have other diagnoses, and there are numerous causes of the less common types of dementia. Aims: This paper provides information about the causes, symptoms, diagnosis and nursing management of some of the different types of less common dementias, with the aim of helping nurses to provide better care to patients and families affected. Methods: This is one of two conn
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42

VanDongen, Antonius M. "Arc: A new target for treating alzheimer's disease." Open Access Government 43, no. 1 (2024): 160–61. http://dx.doi.org/10.56367/oag-043-11454.

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Arc: A new target for treating alzheimer's disease Antonius M. VanDongen, Associate Professor from Duke University, walks us through Arc, a new target for treating Alzheimer’s disease. Alois Alzheimer is a German psychiatrist credited with identifying the first case of the debilitating disease named after him. In 1906, he described neurofibrillary tangles and amyloid plaques in his patient’s brain as unique hallmarks of her dementia. Advances in neuroimaging, genetics, and molecular biology have expanded our understanding of the mechanisms underlying Alzheimer’s disease (AD) significantly. But
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Diniz, Breno S., Meryl A. Butters, Steven M. Albert, Mary Amanda Dew, and Charles F. Reynolds. "Late-life depression and risk of vascular dementia and Alzheimer's disease: systematic review and meta-analysis of community-based cohort studies." British Journal of Psychiatry 202, no. 5 (2013): 329–35. http://dx.doi.org/10.1192/bjp.bp.112.118307.

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BackgroundLate-life depression may increase the risk of incident dementia, in particular of Alzheimer's disease and vascular dementia.AimsTo conduct a systematic review and meta-analysis to evaluate the risk of incident all-cause dementia, Alzheimer's disease and vascular dementia in individuals with late-life depression in population-based prospective studies.MethodA total of 23 studies were included in the meta-analysis. We used the generic inverse variance method with a random-effects model to calculate the pooled risk of dementia, Alzheimer's disease and vascular dementia in older adults w
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Camargos, Einstein Francisco, Marcela Basso Pandolfi, Marco Polo Dias Freitas, et al. "Trazodone for the treatment of sleep disorders in dementia: an open-label, observational and review study." Arquivos de Neuro-Psiquiatria 69, no. 1 (2011): 44–49. http://dx.doi.org/10.1590/s0004-282x2011000100010.

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Sleep disorders (SD) in patients with dementia are very common in clinical practice. The use of antidepressants with hypnotic actions, such as trazodone, plays an important role in these cases. The aim of this study is to present a profile of the use of trazodone in demented patients with SD, as well as a review of trazodone hydrochloride in SD. We evaluated 178 elderly patients with Alzheimer's disease and other dementias, clinically presenting SD and treated with hypnosedative medications. In the one-year period comprising the study, 68 (38.2%) of the 178 had sleep disorders. Most patients (
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Barde, Ms Sonal R. "A Short Review on Nutritional Management of Alzheimer Disease." International Journal for Research in Applied Science and Engineering Technology 12, no. 7 (2024): 1586–600. http://dx.doi.org/10.22214/ijraset.2024.63797.

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Abstract: Amyloid-(A) protein is densely deposited in the brain in Alzheimer's disease (AD), a neurodegenerative condition that also causes memory loss and dementia. There is neuronal destruction and deterioration of neural connections in the cerebral cortex region of the brain in Alzheimer's disease, as well as significant loss of brain mass. It is critical to review medication history, family history, and symptoms when diagnosing Alzheimer's dementia. Alzheimer's disease symptoms usually appear after the age of 65, but the types of Alzheimer disease that run-in families occur earlier. When A
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Hendrie, Hugh C., Kathleen S. Hall, Neelan Pillay, et al. "Alzheimer's Disease is Rare in Cree." International Psychogeriatrics 5, no. 1 (1993): 5–14. http://dx.doi.org/10.1017/s1041610293001358.

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A community survey and subsequent clinical assessment of 192 Cree aged 65 years and over registered in two Reserves in Northern Manitoba identified only one case of probable Alzheimer's disease among eight cases of dementia, giving a prevalence of 0.5% for Alzheimer's disease and 4.2% for all dementias. This contrasted with an age-adjusted prevalence of 3.5% for Alzheimer's disease and 4.2% for all dementias in an age-stratified sample of 241 English-speaking residents of Winnipeg. Although it was not so for all dementias, the difference between the groups for prevalence of Alzheimer's disease
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Malabadi, Ravindra B., Kiran P. Kolkar, Neelambika T. Meti, and Raju K. Chalannavar. "Recent updates on the role of herbal medicine for Alzheimer's disease (Dementia)." International Journal of Current Research in Biosciences and Plant Biology 8, no. 1 (2021): 14–45. http://dx.doi.org/10.20546/ijcrbp.2021.801.002.

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This review paper highlights the use of medicinal plants in the management of Alzheimer's disease and memory deficit. Alzheimer’s disease is the most common form of dementia, a serious brain disorder that impacts daily living through memory loss and cognitive changes. Alzheimer's disease is also age-related neurodegenerative disorders caused by progressive loss of structure or function of neurons, resulting in neuronal cell death. Alzheimer's patients have an acetylcholine deficiency. Stressful conditions, free radicle scavanging and oxidation are often associated with loss of memory and cogni
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Murali, Komal Patel, Joan G. Carpenter, Ann Kolanowski, and Andrea Gilmore Bykovskyi. "Comprehensive Dementia Care Models: State of the Science and Future Directions." Research in Gerontological Nursing 18, no. 1 (2025): 7–16. https://doi.org/10.3928/19404921-20241211-02.

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The rising prevalence of Alzheimer's disease and Alzheimer's disease–related dementias has led to renewed public discourse and policy changes in response to the care needs of persons living with dementia and their care partners. Comprehensive dementia care models are central to many recent policy initiatives, most notably the Centers for Medicare & Medicaid Services Guiding an Improved Dementia Experience model. Gerontological nursing research is uniquely positioned to design and lead research investigating the effectiveness of these initiatives, as well as the dissemination and scaling of
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Yang, Yuan-Han, Kenichi Meguro, Sang-Yun Kim, et al. "Impact of Alzheimer's Disease in Nine Asian Countries." Gerontology 62, no. 4 (2016): 425–33. http://dx.doi.org/10.1159/000443525.

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Background: Asia will soon have the majority of demented patients in the world. Objective: To assess dementia using a uniform data system to update the current status of dementia in Asia. Methods: A uniformed data set was administered in Taiwan, China, Hong Kong, Korea, Japan, Philippines, Thailand, Singapore, and Indonesia to gather data with regard to Alzheimer's disease (AD) and its related issues for these countries. Results: In total, 2,370 AD patients and their caregivers were recruited from 2011 to 2014. The demographic characteristics of these patients and the relationships between pat
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Hofrichter, N., S. Dick, E. Tritschler, A. Knobel, A. Heinz, and M. A. Rapp. "Neuropsychological Performance in both Alzheimer’s Disease and Vascular Dementia is Related to Cardiovascular Comorbidity." European Psychiatry 24, S1 (2009): 1. http://dx.doi.org/10.1016/s0924-9338(09)70608-x.

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Aims:Vascular pathology has been implicated in the pathogenesis of both Alzheimer's disease and vascular dementia. While performance decrements in vascular dementia are by definition thought to be related to vascular load, performance decrements in Alzheimer's disease have not yet been studied in relationship to cardiovascular comorbidity. The aim of this study was to describe neuropsychological performance in patients with mild Alzheimer's disease and vascular dementia in relationship to cardiovascular comorbidity.Method:39 patients suffering form vascular dementia and 34 patients suffering f
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