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Journal articles on the topic 'AMB'

Author: Grafiati

Published: 4 June 2021

Last updated: 19 February 2022

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1

Murphy, Adrian Gerard, Rory Casey, David William Fennelly, Alison Reynolds, Miriam Tosetto, John Hyland, Kieran Sheahan, et al. "The effect of novel small molecule drugs in human explants across the disease sequence in colorectal cancer." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): e13570-e13570. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e13570.

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e13570 Background: The treatment of metastatic colorectal cancer has been improved by combining cytotoxic chemotherapy with bevacizumab. Newer anti-angiogenic agents are required to improve survival rates as response rates with the current therapies are modest. The preclinical development of such drugs is time-consuming and new methods are required to test the efficacy of lead drugs which represent the entire tumor micro-environment. Methods: Chemical screens were performed in zebrafish larvae to identify hits that affected intersegmental angiogenesis. Five lead drugs were then tested for cyto

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Ogoshi, Maho, Shigenori Nobata, and Yoshio Takei. "Potent osmoregulatory actions of homologous adrenomedullins administered peripherally and centrally in eels." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 295, no. 6 (December 2008): R2075—R2083. http://dx.doi.org/10.1152/ajpregu.90688.2008.

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The teleost adrenomedullin (AM) family consists of three groups, AM1/AM4, AM2/AM3, and AM5. In the present study, we examined the effects of homologous AM1, AM2, and AM5 on drinking and renal function after peripheral or central administration in conscious freshwater eels. AM2 and AM5, but not AM1, exhibited dose-dependent (0.01–1 nmol/kg) dipsogenic and antidiuretic effects after intra-arterial bolus injection. The antidiuretic effect was significantly correlated with the degree of associated hypotension. To avoid the potential indirect osmoregulatory effects of AM-induced hypotension, infusi

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Cuenca-Estrella, Manuel, Teresa M. Dı́az-Guerra, Emilia Mellado, and Juan L. Rodrı́guez-Tudela. "Detection of Resistance to Amphotericin B inCandida Isolates by Using Iso-Sensitest Broth." Antimicrobial Agents and Chemotherapy 45, no. 7 (July 1, 2001): 2070–74. http://dx.doi.org/10.1128/aac.45.7.2070-2074.2001.

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ABSTRACT A major limitation of the National Committee for Clinical Laboratory Standards M27-A methodology is reliable detection of amphotericin B (AMB) resistance. The results obtained by using Iso-Sensitest, a synthetic medium, to detect AMB resistance were analyzed and compared with those obtained with RPMI and antibiotic medium 3 (AM3). The ability to detect AMB resistance with RPMI is not enhanced by using a higher inoculum, glucose supplementation at a final concentration of 20 g/liter, spectrophotometric reading, or 24 h of incubation time. Testing using AM3 and an inoculum of 103 CFU/ml

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Beale, S., B. Shafai, P. LaRocca, and E. Cusson. "Adaptive Forced Balancing for Multivariable Systems." Journal of Dynamic Systems, Measurement, and Control 117, no. 4 (December 1, 1995): 496–502. http://dx.doi.org/10.1115/1.2801106.

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Active magnetic bearing (AMB) actuators support rotors without friction but require feedback control for stabilization and performance. Autobalancing compensation causes AMBs to spin a rotor about its inertial axis to eliminate synchronous force transmission from mass unbalance. Because mass unbalance constitutes a sinusoidal sensor disturbance within the bandwidth, conventional methods can either cause instability or fail to preserve desired bandwidth. We introduce a new method called adaptive forced balancing (AFB) which overcomes these problems. We consider AFB with a frequency tracking cap

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Zhang, Tao, Wei Ni, Sha Sha Wu, Hui Ping Zhang, and Jian Xiang Ji. "Rotor Vibration Control of Active Magnetic Bearing System Using Adaptive Forced Balancing Method." Applied Mechanics and Materials 268-270 (December 2012): 1527–30. http://dx.doi.org/10.4028/www.scientific.net/amm.268-270.1527.

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The adaptive forced balancing (AFB) method was used to estimate and eliminate the rotor vibration with unknown amplitudes and frequencies in active magnetic bearing (AMB) feedback control systems. Firstly, the rotor vibration producing mechanisms of AMB were analyzed. Then, the AFB under the assumption of unknown rotational frequency and amplitude are designed. Finally the simulation results show that the AFB method proposed in this paper makes it possible to completely reject unknown sinusoidal disturbance in a closed loop control system

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6

Lobato-Freitas, Carolina, Andreia Machado Brito-da-Costa, Ricardo Jorge Dinis-Oliveira, Helena Carmo, Félix Carvalho, João Pedro Silva, and Diana Dias-da-Silva. "Overview of Synthetic Cannabinoids ADB-FUBINACA and AMB-FUBINACA: Clinical, Analytical, and Forensic Implications." Pharmaceuticals 14, no. 3 (February 25, 2021): 186. http://dx.doi.org/10.3390/ph14030186.

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ADB-FUBINACA and AMB-FUBINACA are two synthetic indazole-derived cannabinoid receptor agonists, up to 140- and 85-fold more potent, respectively, than trans-∆9-tetrahydrocannabinol (∆9-THC), the main psychoactive compound of cannabis. Synthesised in 2009 as a pharmaceutical drug candidate, the recreational use of ADB-FUBINACA was first reported in 2013 in Japan, with fatal cases being described in 2015. ADB-FUBINACA is one of the most apprehended and consumed synthetic cannabinoid (SC), following AMB-FUBINACA, which emerged in 2014 as a drug of abuse and has since been responsible for several

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7

Oakley, Karen L., Caroline B. Moore, and David W. Denning. "In Vitro Activity of the Echinocandin Antifungal Agent LY303,366 in Comparison with Itraconazole and Amphotericin B against Aspergillus spp." Antimicrobial Agents and Chemotherapy 42, no. 10 (October 1, 1998): 2726–30. http://dx.doi.org/10.1128/aac.42.10.2726.

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ABSTRACT LY303,366 (LY) is a novel derivative of the echinocandin class of antifungal agents. The in vitro activities of LY, itraconazole (ITZ), and amphotericin B (AMB) were assessed against 60Aspergillus isolates, including 35 isolates of A. fumigatus, eight isolates of A. terreus, eight isolates of A. flavus, eight isolates of A. niger and one isolate of A. nidulans. Four A. fumigatus isolates were resistant to ITZ. Susceptibility testing for all drugs was performed with a broth microdilution procedure. LY was tested in two media: antibiotic medium 3 (AM3) and Casitone with 2% glucose (CAS)

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Nobata, Shigenori, Maho Ogoshi, and Yoshio Takei. "Potent cardiovascular actions of homologous adrenomedullins in eels." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 294, no. 5 (May 2008): R1544—R1553. http://dx.doi.org/10.1152/ajpregu.00707.2007.

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Adrenomedullin (AM), known as a multifunctional hormone in mammals, forms a unique family of five paralogous peptides in teleost fish. To examine their cardiovascular effects using homologous AMs in eels, we isolated cDNAs encoding four eel AMs, and named AM1 (ortholog of mammalian AM), AM2, AM3 (paralog of AM2 generated only in teleost lineage), and AM5 according to the known teleost AM sequences. Unlike pufferfish, not only AM1 but AM2/3 and AM5 were expressed ubiquitously in various eel tissues. Synthetic mature AM1, AM2, and AM5 exhibited vasodepressor effects after intra-arterial injectio

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Louie, Arnold, Pamela Kaw, Partha Banerjee, Weiguo Liu, George Chen, and Michael H. Miller. "Impact of the Order of Initiation of Fluconazole and Amphotericin B in Sequential or Combination Therapy on Killing of Candida albicans In Vitro and in a Rabbit Model of Endocarditis and Pyelonephritis." Antimicrobial Agents and Chemotherapy 45, no. 2 (February 1, 2001): 485–94. http://dx.doi.org/10.1128/aac.45.2.485-494.2001.

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ABSTRACT In vitro time-kill studies and a rabbit model of endocarditis and pyelonephritis were used to define the impact that the order of exposure of Candida albicans to fluconazole (FLC) and amphotericin B (AMB), as sequential and combination therapies, had on the susceptibility of C. albicans to AMB and on the outcome. The contribution of FLC-induced resistance to AMB for C. albicans also was assessed. In vitro, AMB monotherapy rapidly killed each of four C. albicans strains; FLC alone was fungistatic. Preincubation of these fungi with FLC for 18 h prior to exposure to AMB decreased their s

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Go, Seok Jo, Chi Yen Kim, Min Kyu Park, Young Jin Lee, and Bin Yao. "Development of Exclusive Controller and HILS for Active Magnetic Bearing System." Applied Mechanics and Materials 241-244 (December 2012): 1365–69. http://dx.doi.org/10.4028/www.scientific.net/amm.241-244.1365.

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The active magnetic bearing system has been studied for long period. Comparing with long research history, the AMB application into industrial field is shown slowly for various causes. One of primary factor is to make up exclusive controller which can generate fast linear current output. Thus, this paper developed the exclusive AMB controller mounted high speed DSP which can operate so fast control calculation that improve system response ability. Especially, to consider the fusion of AMB system and control software, the development is conducted in HILS system with dSPACE from the beginning. A

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Otsubo, Takakazu, Kazuo Maruyama, Shigefumi Maesaki, Yoshitsugu Miyazaki, Eitaro Tanaka, Tomoko Takizawa, Kunikazu Moribe, Kazunori Tomono, Takayoshi Tashiro, and Shigeru Kohno. "Long-Circulating Immunoliposomal Amphotericin B against Invasive Pulmonary Aspergillosis in Mice." Antimicrobial Agents and Chemotherapy 42, no. 1 (January 1, 1998): 40–44. http://dx.doi.org/10.1128/aac.42.1.40.

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ABSTRACT We investigated the efficacy of long-circulating immunoliposomal amphotericin B (AmB) against invasive pulmonary aspergillosis in mice using three types of liposomal AmB: conventional liposomal AmB (AmBisome), a long-circulating liposomal AmB and prepared by coating the liposome surface with polyethylene glycol (PEG; PEG-L-AmB), long-circulating immunoliposomal AmB (34A-PEG-L-AmB). The survival rates for mice with invasive pulmonary aspergillosis treated with an intravenous dose of 2 mg of AmBisome, PEG-L-AmB, or 34A-PEG-L-AmB per kg of body weight were 16.7, 83.3, and 100%, respectiv

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Hickson, Ford, Max Appenroth, Uwe Koppe, Axel J. Schmidt, David Reid, and Peter Weatherburn. "Sexual and Mental Health Inequalities across Gender Identity and Sex-Assigned-at-Birth among Men-Who-Have-Sex-with-Men in Europe: Findings from EMIS-2017." International Journal of Environmental Research and Public Health 17, no. 20 (October 10, 2020): 7379. http://dx.doi.org/10.3390/ijerph17207379.

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Some men who have sex with men (MSM) were assigned female at birth (AFB) and/or identify as trans men. Little is known about how these men differ from other MSM. We compared sexual and mental health indicators from the European MSM Internet Survey (EMIS-2017), comparing men AFB and/or currently identifying as trans men with those assigned male at birth (AMB) who identified as men. EMIS-2017 was an opportunistic 33-language online sexual health survey for MSM recruiting throughout Europe. We used regression models adjusting for age, country of residence and employment status to examine differen

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Goldblum, David, Kaspar Rohrer, Beatrice E. Frueh, Regula Theurillat, Wolfgang Thormann, and Stefan Zimmerli. "Ocular Distribution of Intravenously Administered Lipid Formulations of Amphotericin B in a Rabbit Model." Antimicrobial Agents and Chemotherapy 46, no. 12 (December 2002): 3719–23. http://dx.doi.org/10.1128/aac.46.12.3719-3723.2002.

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ABSTRACT Little is known about the ocular penetration of amphotericin B (AMB) and its lipid formulations, the current drug of choice in fungal endophthalmitis. The ocular distribution of AMB lipid complex (ABLC), liposomal AMB (L-AMB), and AMB deoxycholate (D-AMB) was studied in a rabbit model. D-AMB (1 mg/kg of body weight/day), ABLC (5 mg/kg/day), or L-AMB (5 mg/kg/day) was given intravenously to rabbits as a single dose or as repeated daily doses on 7 consecutive days after induction of unilateral uveitis by intravitreal injection of endotoxin. AMB concentrations in aqueous humor, vitreous

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Nimtrakul, Pataranapa, Waree Tiyaboonchai, and Supaporn Lamlertthon. "Amphotericin B Loaded Nanostructured Lipid Carriers for Parenteral Delivery: Characterization, Antifungal and In vitro Toxicity Assessment." Current Drug Delivery 16, no. 7 (October 3, 2019): 645–53. http://dx.doi.org/10.2174/1567201816666190729145223.

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Background: Amphotericin B (AmB) is important for the treatment of systemic fungal infections. Nowadays, only intravenous administration (IV) of AmB has been available due to its low aqueous solubility. Two forms of AmB are available. The first is Fungizone®, a mixture of AmB and sodium deoxcycholate that produces severe nephrotoxicity. The second are lipid-based formulations that reduce nephrotoxicity, but they are costly and require higher dose than Fungizone®. Thus, a cheaper delivery system with reduced AmB toxicity is required. Objective: To develop and characterize AmB loaded-nanostructu

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Risovic, Verica, Michael Boyd, Eugene Choo, and Kishor M. Wasan. "Effects of Lipid-Based Oral Formulations on Plasma and Tissue Amphotericin B Concentrations and Renal Toxicity in Male Rats." Antimicrobial Agents and Chemotherapy 47, no. 10 (October 2003): 3339–42. http://dx.doi.org/10.1128/aac.47.10.3339-3342.2003.

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ABSTRACT The purpose of this study was to determine the effects of various lipid and mixed-micelle formulations on the oral absorption and renal toxicity of amphotericin B (AMB) in rats. The maximum concentration of AMB in plasma and the area under the concentration-time curve for 0 to 24 h for AMB were elevated in rats administered triglyceride (TG)-rich AMB formulations in comparison to those in rats given (i) AMB preformulated as a micelle containing sodium deoxycholate with sodium phosphate as a buffer (DOC-AMB), (ii) an AMB-lipid complex suspension, or (iii) AMB solubilized in methanol. F

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Dórea, E. L., L. Yu, I. De Castro, S. B. Campos, M. Ori, E. M. Vaccari, C. da S. Lacaz, and A. C. Seguro. "Nephrotoxicity of amphotericin B is attenuated by solubilizing with lipid emulsion." Journal of the American Society of Nephrology 8, no. 9 (September 1997): 1415–22. http://dx.doi.org/10.1681/asn.v891415.

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Nephrotoxicity is the major adverse effect of conventional amphotericin B (AMB/D), often limiting administration of full dosage. The new liposomal amphotericin B seems to be less toxic. The new liposomal amphotericin B seems to be less toxic. In this study, it is proposed that solubilizing the standard AMB/D preparation with 10% lipid emulsion will attenuate nephrotoxicity. Rats were injected with either AMB/D (Fungizone), AMB, AMB/D plus lipid emulsion (AMB/D/LE), or sodium deoxycholate (D). Renal function studies were performed on day 5. To assess a direct tubular toxic effect, isolated rat

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Nimtrakul, Pataranapa, Desmond B. Williams, Waree Tiyaboonchai, and Clive A. Prestidge. "Copolymeric Micelles Overcome the Oral Delivery Challenges of Amphotericin B." Pharmaceuticals 13, no. 6 (June 11, 2020): 121. http://dx.doi.org/10.3390/ph13060121.

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Classified as a Biopharmaceutical Classification System (BCS) class IV drug, amphotericin B (AmB) has low aqueous solubility and low permeability leading to low oral bioavailability. To improve these limitations, this study investigated the potential of AmB-loaded polymeric micelles (AmB-PM) to increase intestinal absorption. AmB-PM were prepared with polyvinyl caprolactam–polyvinyl acetate–polyethylene glycol copolymer (Soluplus®) as a polymeric carrier and used a modified solvent diffusion and microfluidics (NanoAssemblr®) method. AmB-PM have a mean particle size of ~80 nm and are mono-dispe

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Walker, Scott, Sandra A. N. Tailor, Mark Lee, Lisa Louie, Marie Louie, and Andrew E. Simor. "Amphotericin B in Lipid Emulsion: Stability, Compatibility, and In Vitro Antifungal Activity." Antimicrobial Agents and Chemotherapy 42, no. 4 (April 1, 1998): 762–66. http://dx.doi.org/10.1128/aac.42.4.762.

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ABSTRACT Newer formulations of amphotericin B (AmB) complexed with liposomes or lipid suspensions have been developed. Preliminary studies have suggested that AmB in Intralipid (IL) may be as effective as, but less toxic than, conventional formulations of AmB, but few data are available regarding its stability, compatibility, or in vitro antifungal activity. A compatibility study was done to evaluate the effects of AmB concentrations in IL containing either 10 or 20% soybean oil. The effects of temperature, shaking, and AmB and IL concentrations on the stability of AmB-IL suspensions were anal

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Ruijgrok, Elisabeth J., Marcel H. A. M. Fens, Irma A. J. M. Bakker-Woudenberg, Els W. M. van Etten, and Arnold G. Vulto. "Nebulized Amphotericin B Combined with Intravenous Amphotericin B in Rats with Severe Invasive Pulmonary Aspergillosis." Antimicrobial Agents and Chemotherapy 50, no. 5 (May 2006): 1852–54. http://dx.doi.org/10.1128/aac.50.5.1852-1854.2006.

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ABSTRACT Nebulized amphotericin B (AMB) combined with intravenous AMB was studied in persistently leukopenic rats with invasive pulmonary aspergillosis. Pulmonary concentrations of AMB after aerosol treatment were substantially higher than after intravenous liposomal AMB. Nebulized liposomal AMB in addition to intravenous AMB resulted in significantly prolonged survival compared to controls.

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Bekersky, Ihor, Robert M. Fielding, Dawna E. Dressler, Jean W. Lee, Donald N. Buell, and Thomas J. Walsh. "Plasma Protein Binding of Amphotericin B and Pharmacokinetics of Bound versus Unbound Amphotericin B after Administration of Intravenous Liposomal Amphotericin B (AmBisome) and Amphotericin B Deoxycholate." Antimicrobial Agents and Chemotherapy 46, no. 3 (March 2002): 834–40. http://dx.doi.org/10.1128/aac.46.3.834-840.2002.

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ABSTRACT Unilamellar liposomal amphotericin B (AmBisome) (liposomal AMB) reduces the toxicity of this antifungal drug. The unique composition of liposomal AMB stabilizes the liposomes, producing higher sustained drug levels in plasma and reducing renal and hepatic excretion. When liposomes release their drug payload, unbound, protein-bound, and liposomal drug pools may exist simultaneously in the body. To determine the amounts of drug in these pools, we developed a procedure to measure unbound AMB in human plasma by ultrafiltration and then used it to characterize AMB binding in vitro and to a

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Bekersky, Ihor, Robert M. Fielding, Dawna E. Dressler, Jean W. Lee, Donald N. Buell, and Thomas J. Walsh. "Pharmacokinetics, Excretion, and Mass Balance of Liposomal Amphotericin B (AmBisome) and Amphotericin B Deoxycholate in Humans." Antimicrobial Agents and Chemotherapy 46, no. 3 (March 2002): 828–33. http://dx.doi.org/10.1128/aac.46.3.828-833.2002.

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ABSTRACT The pharmacokinetics, excretion, and mass balance of liposomal amphotericin B (AmBisome) (liposomal AMB) and the conventional formulation, AMB deoxycholate (AMB-DOC), were compared in a phase IV, open-label, parallel study in healthy volunteers. After a single 2-h infusion of 2 mg of liposomal AMB/kg of body weight or 0.6 mg of AMB-DOC/kg, plasma, urine, and feces were collected for 168 h. The concentrations of AMB were determined by liquid chromatography tandem mass spectrometry (plasma, urine, feces) or high-performance liquid chromatography (HPLC) (plasma). Infusion-related side ef

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Trejtnar, František, Jana Mandíková, Jana Kočíncová, and Marie Volková. "Renal Handling of Amphotericin B and Amphotericin B-Deoxycholate and Potential Renal Drug-Drug Interactions with Selected Antivirals." Antimicrobial Agents and Chemotherapy 58, no. 10 (June 23, 2014): 5650–57. http://dx.doi.org/10.1128/aac.02829-14.

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ABSTRACTAmphotericin B (AmB) is excreted via the renal excretion route. This excretion process may result in nephrotoxicity. However, relevant information on the precise renal excretion mechanisms is not available. The aim of the study was to analyze the possible interaction of AmB or its prodrug AmB deoxycholate (AmB-DOC) with the typical renal organic anion transporters (OATs) and organic cation transporters (OCTs), using cellular and organ models. The relevant transport systems were then investigated in terms of the drug-drug interactions of AmB-DOC with antivirals that might potentially be

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Inselmann, G., A. Volkmann, and H. T. Heidemann. "Comparison of the Effects of Liposomal Amphotericin B and Conventional Amphotericin B on Propafenone Metabolism and Hepatic Cytochrome P-450 in Rats." Antimicrobial Agents and Chemotherapy 44, no. 1 (January 1, 2000): 131–33. http://dx.doi.org/10.1128/aac.44.1.131-133.2000.

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ABSTRACT The effects of conventional amphotericin B (AmB) dissolved in sodium deoxycholate on microsomal cytochrome P-450 concentrations and propafenone metabolism to 5-hydroxy-propafenone andN-desalkyl-propafenone were compared with those of liposomal AMB (Li-AMB) in rats. AmB (3 mg/kg/day, intravenously [i.v.]) given for 4 days caused a significant decrease in the concentration of hepatic microsomal cytochrome P-450 (0.43 ± 0.06 nmol/mg versus 0.62 ± 0.05 nmol/mg for the control [P < 0.05]). Following the application of Li-AMB (15 mg/kg/day, i.v.), hepatic microsomal cytochrome P-450 conc

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Nath, Christa E., Peter J. Shaw, Robyn Gunning, Andrew J. McLachlan, and John W. Earl. "Amphotericin B in Children with Malignant Disease: a Comparison of the Toxicities and Pharmacokinetics of Amphotericin B Administered in Dextrose versus Lipid Emulsion." Antimicrobial Agents and Chemotherapy 43, no. 6 (June 1, 1999): 1417–23. http://dx.doi.org/10.1128/aac.43.6.1417.

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ABSTRACT In a prospective, randomized clinical trial, the toxicity of 1 mg of amphotericin B (AmB) per kg of body weight per day infused in 5% dextrose was compared with that of AmB infused in lipid emulsion in children with malignant disease. In an analysis of 82 children who received a full course of 6 days or more of AmB (117 courses), it was shown that there were significant increases in plasma urea and creatinine concentrations and in potassium requirement after 6 days of therapy with both AmB infused in dextrose and AmB infused in lipid emulsion, with there being no difference between th

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Xu, Hongmei, Fangfang Teng, Feilong Zhou, Li Zhu, Yi Wen, Runliang Feng, and Zhimei Song. "Linolenic acid-modified MPEG-PEI micelles for encapsulation of amphotericin B." Future Medicinal Chemistry 11, no. 20 (October 2019): 2647–62. http://dx.doi.org/10.4155/fmc-2018-0580.

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Aim: To encapsulate amphotericin B (AmB) with reduced toxicity and comparable activity. Results & methodology: The α-linolenic acid (ALA)-modified monomethoxy polyethylene glycol-g-PEI-g-ALA conjugate was employed to prepare AmB-loaded micelles (AmB-M). In vitro activity and release behavior of AmB-M were investigated. AmB-M enhanced AmB's water-solubility to 1.2 mg/ml, showing good storage stability. AmB-M could achieve a sustained and slow release of AmB, low hemolysis activity and negligible kidney toxicity when compared with commercial AmB injection. Antifungal activity and biofilm inh

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Otsubo, Takakazu, Shigefumi Maesaki, Mohammad Ashraf Hossain, Yoshihiro Yamamoto, Kazunori Tomono, Takayoshi Tashiro, Junzo Seki, Yoshifumi Tomii, Satoru Sonoke, and Shigeru Kohno. "In Vitro and In Vivo Activities of NS-718, a New Lipid Nanosphere Incorporating Amphotericin B, againstAspergillus fumigatus." Antimicrobial Agents and Chemotherapy 43, no. 3 (March 1, 1999): 471–75. http://dx.doi.org/10.1128/aac.43.3.471.

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ABSTRACT We evaluated the in vitro and in vivo potencies of a new lipid nanosphere that incorporates amphotericin B (AmB), NS-718, againstAspergillus fumigatus. The in vitro activity of NS-718 (the MIC at which 90% of strains are inhibited [MIC90], 0.25 μg/ml) against 18 isolates of A. fumigatus was similar to that of deoxycholate AmB (D-AmB; Fungizone; MIC90, 0.25 μg/ml), but NS-718 was more potent than liposomal AmB (L-AmB; AmBisome; MIC90, 1.0 μg/ml). The in vivo efficacy of NS-718 in a rat model of invasive pulmonary aspergillosis was compared with those of D-AmB and L-AmB. A low dose (1 m

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Stergiopoulou, Theodouli, Joseph Meletiadis, Tin Sein, Paraskevi Papaioannidou, Thomas J. Walsh, and Emmanuel Roilides. "Synergistic Interaction of the Triple Combination of Amphotericin B, Ciprofloxacin, and Polymorphonuclear Neutrophils against Aspergillus fumigatus." Antimicrobial Agents and Chemotherapy 55, no. 12 (September 12, 2011): 5923–29. http://dx.doi.org/10.1128/aac.00548-11.

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ABSTRACTAspergillusis damaged by polymorphonuclear neutrophils (PMNs) by means of nonoxidative and oxidative mechanisms, which may be affected by antifungal and antibacterial agents that patients with invasive pulmonary aspergillosis often receive. The pharmacodynamic interactions among deoxycholate amphotericin B (AMB), ciprofloxacin (CIP), and human PMNs againstAspergillus fumigatusgrowth are unknown. We therefore studied the interactions between 0.032 to 2.0 μg/ml of AMB, 0.1 to 50 μg/ml of CIP at a fixed AMB/CIP ratio of 1:3.125, and PMNs from six donors at an effector-to-target (E:T) rati

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Groll, Andreas H., Diana Mickiene, Stephen C. Piscitelli, and Thomas J. Walsh. "Distribution of Lipid Formulations of Amphotericin B into Bone Marrow and Fat Tissue in Rabbits." Antimicrobial Agents and Chemotherapy 44, no. 2 (February 1, 2000): 408–10. http://dx.doi.org/10.1128/aac.44.2.408-410.2000.

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ABSTRACT The distribution of the three currently available lipid formulations of amphotericin B (AmB) into bone marrow and fat tissue was evaluated in noninfected rabbits. Groups of four animals each received either 1 mg of AmB deoxycholate (D-AmB) per kg of body weight per day or 5 mg of AmB colloidal dispersion, AmB lipid complex, or liposomal AmB per kg per day for seven doses. Plasma, bone marrow, fat, and liver were collected at autopsy, and AmB concentrations were determined by high-performance liquid chromatography. At the investigated dosages of 5 mg/kg/day, all AmB lipid formulations

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Blum, Gerhard, Caroline Hörtnagl, Emina Jukic, Thomas Erbeznik, Thomas Pümpel, Hermann Dietrich, Markus Nagl, Cornelia Speth, Günter Rambach, and Cornelia Lass-Flörl. "New Insight into Amphotericin B Resistance in Aspergillus terreus." Antimicrobial Agents and Chemotherapy 57, no. 4 (January 14, 2013): 1583–88. http://dx.doi.org/10.1128/aac.01283-12.

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ABSTRACTAmphotericin B (AMB) is the predominant antifungal drug, but the mechanism of resistance is not well understood. We compared thein vivovirulence of an AMB-resistantAspergillus terreus(ATR) isolate with that of an AMB-susceptibleA. terreusisolate (ATS) using a murine model for disseminated aspergillosis. Furthermore, we analyzed the molecular basis of intrinsic AMB resistancein vitroby comparing the ergosterol content, cell-associated AMB levels, AMB-induced intracellular efflux, and prooxidant effects between ATR and ATS. Infection of immunosuppressed mice with ATS or ATR showed that t

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Sánchez-Brunete, J. A., M. A. Dea, S. Rama, F. Bolás, J. M. Alunda, R. Raposo, M. T. Méndez, S. Torrado-Santiago, and J. J. Torrado. "Treatment of Experimental Visceral Leishmaniasis with Amphotericin B in Stable Albumin Microspheres." Antimicrobial Agents and Chemotherapy 48, no. 9 (September 2004): 3246–52. http://dx.doi.org/10.1128/aac.48.9.3246-3252.2004.

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ABSTRACT Hydrophilic albumin microspheres are proposed as a new delivery system for amphotericin B (AMB; AMB microspheres). The acute toxicity of AMB microspheres was lower than that of the AMB-deoxycholate (AMB-Doc) reference formulation in hamsters. Lethal doses in healthy and infected animals were improved at least eight times. Intravenous bolus administration of doses of AMB microspheres up to 40 mg/kg of body weight did not produce acute symptoms of toxicity. The efficacy of this new formulation was tested against Leishmania infantum-infected hamsters at doses of 2, 10, 20, and 40 mg/kg.

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Santos, Délia C. M., Marta L. Lima, Juliano S. Toledo, Paula A. Fernandes, Marta M. G. Aguiar, Ángeles López-Gonzálvez, Lucas A. M. Ferreira, Ana Paula Fernandes, and Coral Barbas. "Metabolomics as a tool to evaluate the toxicity of formulations containing amphotericin B, an antileishmanial drug." Toxicology Research 5, no. 6 (2016): 1720–32. http://dx.doi.org/10.1039/c6tx00253f.

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Salama, Suzette, and Coleman Rotstein. "Reduction in the Nephrotoxicity of Amphotericin B when Administered in 20% Intralipid." Canadian Journal of Infectious Diseases 8, no. 3 (1997): 157–60. http://dx.doi.org/10.1155/1997/827297.

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The administration of amphotericin B (AmB) is often limited by the development of nephrotoxicity. In a pilot crossover trial, aqueous AmB followed by a new preparation of a mixture of AmB with 20% intralipid (AmB-IL) was administered to 10 immunocompromised patients for systemic fungal infections caused byCandidaspecies. Mean total dose and duration of therapy with AmB-IL exceeded that of aqueous AmB (649±165 mg versus 394±105 mg, P=0.061 and 13.2±2.5 days versus 9±2.1 days, P=0.31). However, mean creatinine clearance of the patients rose during AmB-IL therapy by 10.7±7.7 mL/min (P=0.03). AmB-

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Araújo, Ivonete Batista, C. Ramon N. Brito, Isabel A. Urbano, Victor A. Dominici, Miguel A. Silva Filho, Walteçá L. L. Silveira, Bolívar P. G. L. Damasceno, Aldo Cunha Medeiros, and E. Sócrates T. Egito. "Similarity between the in vitro activity and toxicity of two different fungizone™ / lipofundin™ admixtures." Acta Cirurgica Brasileira 20, suppl 1 (2005): 129–33. http://dx.doi.org/10.1590/s0102-86502005000700022.

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PURPOSE: Amphotericin B (AmB), an antifungal agent that presents a broad spectrum of activity, remains the gold standard in the antifungal therapy. However, sometimes the high level of toxicity forbids its clinical use. The aim of this work was to evaluate and compare the efficacy and toxicity in vitro of Fungizon™ (AmB-D) and two new different AmB formulations. METHODS: three products were studied: Fungizon™, and two Fungizon™ /Lipofundin™ admixtures, which were diluted through two methods: in the first one, Fungizon™ was previously diluted with water for injection and then, in Lipofundin™ (A

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Montagna, Maria Teresa, Grazia Lovero, Caterina Coretti, Osvalda De Giglio, Domenico Martinelli, Andrea Bedini, Mario Delia, Antonio Rosato, Mauro Codeluppi, and Giuseppina Caggiano. "In vitro activities of amphotericin B deoxycholate and liposomal amphotericin B against 604 clinical yeast isolates." Journal of Medical Microbiology 63, no. 12 (December 1, 2014): 1638–43. http://dx.doi.org/10.1099/jmm.0.075507-0.

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We determined the in vitro antifungal activity of liposomal amphotericin B (L-AmB) against 604 clinical yeast isolates. Amphotericin B deoxycholate (D-AmB) was tested in parallel against all the isolates. Susceptibility testing was performed according to the Clinical and Laboratory Standards Institute (CLSI) M27-A3 method. Overall, L-AmB was highly active against the isolates (mean MIC, 0.42 µg ml−1; MIC90, 1 µg ml−1; 97.2 % of MICs were ≤1 µg ml−1) and comparable to D-AmB (mean MIC, 0.48 µg ml−1; MIC90, 1 µg ml−1; 97.3 % of MICs were ≤1 µg ml−1). The in vitro activity of D-AmB and L-AmB was c

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Weiler, Stefan, Rosa Bellmann-Weiler, Michael Joannidis, and Romuald Bellmann. "Penetration of Amphotericin B Lipid Formulations into Pleural Effusion." Antimicrobial Agents and Chemotherapy 51, no. 11 (September 4, 2007): 4211–13. http://dx.doi.org/10.1128/aac.01087-07.

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ABSTRACT The penetration of the amphotericin B (AMB) lipid formulations (liposomal AMB, AMB colloidal dispersion, and AMB lipid complex formulations) into pleural effusions in seven critically ill patients was assessed. AMB was detected in all pleural effusion samples at concentrations ranging from 0.02 to 0.43 μg/ml. The penetration ratio was 3 to 44%.

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Fan, Yuying, Yue Wang, and Jianping Xu. "Comparative Genome Sequence Analyses of Geographic Samples of Aspergillus fumigatus—Relevance for Amphotericin B Resistance." Microorganisms 8, no. 11 (October 28, 2020): 1673. http://dx.doi.org/10.3390/microorganisms8111673.

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Amphotericin B (AMB) is a major fungicidal polyene agent that has a broad spectrum of action against invasive fungal infections. AMB is typically used as the last-line drug against serious and life-threatening infections when other drugs have failed to eliminate the fungal pathogens. Recently, AMB resistance in Aspergillus fumigatus has become more evident. For example, a high rate of AMB resistance (96%) was noted in the A. fumigatus population in Hamilton, Ontario, Canada. AMB-resistant strains have also been found in other countries. However, the mechanism of AMB resistance remains largely

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Heinemann, V., B. Kähny, U. Jehn, D. Mühlbayer, A. Debus, K. Wachholz, D. Bosse, H. J. Kolb, and W. Wilmanns. "Serum pharmacology of amphotericin B applied in lipid emulsions." Antimicrobial Agents and Chemotherapy 41, no. 4 (April 1997): 728–32. http://dx.doi.org/10.1128/aac.41.4.728.

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Application of amphotericin B in lipid emulsions (AmB/L) reduced membrane toxicity in vitro and decreased amphotericin B-associated toxic side effects in vivo when compared to that of amphotericin B applied in 5% glucose (AmB/G). Therefore, a comparative analysis of the pharmacological parameters of AmB/L and AmB/G was performed. Thirteen patients were analyzed, and nine of these patients received a subsequent treatment with AmB/G and AmB/L. In patients in both treatment groups amphotericin B showed a biphasic elimination from serum, with a prolonged terminal half-life of approximately 27 h. P

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Andes, D., N. Safdar, K. Marchillo, and R. Conklin. "Pharmacokinetic-Pharmacodynamic Comparison of Amphotericin B (AMB) and Two Lipid-Associated AMB Preparations, Liposomal AMB and AMB Lipid Complex, in Murine Candidiasis Models." Antimicrobial Agents and Chemotherapy 50, no. 2 (February 2006): 674–84. http://dx.doi.org/10.1128/aac.50.2.674-684.2006.

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ABSTRACT It is generally accepted that the lipid formulations of amphotericin B (AMB) are not as potent as conventional AMB on a milligram-per-kilogram basis. We used a neutropenic murine disseminated candidiasis model to compare the in vivo potencies of AMB, liposomal AMB (L-AMB), and AMB lipid complex (ABLC) pharmacodynamically. The pharmacokinetics of the antifungals were examined in serum and in three organs commonly seeded in disseminated candidiasis (kidneys, liver, and lung). Both single-dose time-kill studies and multiple-dosing-regimen studies were used with each of the compounds. Det

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Lewis, Russell E., Guangling Liao, Jinggou Hou, Georgios Chamilos, Randall A. Prince, and Dimitrios P. Kontoyiannis. "Comparative Analysis of Amphotericin B Lipid Complex and Liposomal Amphotericin B Kinetics of Lung Accumulation and Fungal Clearance in a Murine Model of Acute Invasive Pulmonary Aspergillosis." Antimicrobial Agents and Chemotherapy 51, no. 4 (January 29, 2007): 1253–58. http://dx.doi.org/10.1128/aac.01449-06.

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ABSTRACT The reformulation of amphotericin B (AMB) into a lipid complex (AMB lipid complex [ABLC]) or liposomal carrier (liposomal AMB [L-AMB]) changes the rate and extent of drug distribution to the lung. The importance of pharmacokinetic differences among the various lipid AMB formulations in the treatment of invasive pulmonary aspergillosis (IPA) remains unknown. We compared the kinetics of AMB lung accumulation and fungal clearance of ABLC- and L-AMB-treated mice with acute IPA. BALB/c mice were immunosuppressed with cyclophosphamide and cortisone before intranasal inoculation with 1.5 × 1

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Chen, Tao, Lawrence Mwenge, Shabir Lakhi, Duncan Chanda, Peter Mwaba, Síle F. Molloy, Adrian Gheorghe, et al. "Healthcare Costs and Life-years Gained From Treatments Within the Advancing Cryptococcal Meningitis Treatment for Africa (ACTA) Trial on Cryptococcal Meningitis: A Comparison of Antifungal Induction Strategies in Sub-Saharan Africa." Clinical Infectious Diseases 69, no. 4 (March 13, 2019): 588–95. http://dx.doi.org/10.1093/cid/ciy971.

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Abstract Background Mortality from cryptoccocal meningitis remains high. The ACTA trial demonstrated that, compared with 2 weeks of amphotericin B (AmB) plus flucystosine (5FC), 1 week of AmB and 5FC was associated with lower mortality and 2 weeks of oral flucanozole (FLU) plus 5FC was non-inferior. Here, we assess the cost-effectiveness of these different treatment courses. Methods Participants were randomized in a ratio of 2:1:1:1:1 to 2 weeks of oral 5FC and FLU, 1 week of AmB and FLU, 1 week of AmB and 5FC, 2 weeks of AmB and FLU, or 2 weeks of AmB and 5FC in Malawi, Zambia, Cameroon, and

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Tran, Thi H. Yen, Thi T. Giang Vu, and Thi M. H. Pham. "Preparation and Characterization of Liposomes Double-loaded with Amphotericin B and Amphotericin B/hydroxypropyl-beta-cyclodextrin Inclusion Complex." Pharmaceutical Nanotechnology 9, no. 3 (August 13, 2021): 236–44. http://dx.doi.org/10.2174/2211738509666210310160436.

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Background: Amphotericin B (AMB) is water-insoluble polyene, which has a broad spectrum of antifungal activity. The hydrophobic drug only exits in the phospholipid bilayer, leading to a low-drug liposomal loading capacity. Objectives: This study is designed to prepare water-soluble inclusion complex (IC) between AMB and cyclodextrin (CD) to formulate liposomal vesicles, double-loaded with drug molecules in the phospholipid bilayer and AMB/CD IC in the aqueous core. Methods: Water-soluble AMB/CD IC was prepared by pH adjustment of the aqueous media and consequently characterized by scanning ele

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Wasan, K. M., and J. S. Conklin. "Evaluation of renal toxicity and antifungal activity of free and liposomal amphotericin B following a single intravenous dose to diabetic rats with systemic candidiasis." Antimicrobial Agents and Chemotherapy 40, no. 8 (August 1996): 1806–10. http://dx.doi.org/10.1128/aac.40.8.1806.

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Since fungal infections are prevalent in diabetic patients, in whom treatment is often complicated by underlying renal disease and dyslipidemias, the purpose of the present study was to determine if the antifungal activity and nephrotoxic effects of amphotericin B (AmB) and liposomal AmB (L-AmB) are different in nondiabetic (normolipidemic) rats compared with those in diabetic (dyslipidemic) rats with systemic candidiasis. Non diabetic and diabetic rats infected with Candida albicans received a single intravenous dose of either AmB (0.8 mg of AmB per kg of body weight), L-AmB (0.8, 2, or 4 mg

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Kirkpatrick, William R., Brent J. Coco, and Thomas F. Patterson. "Sequential or Combination Antifungal Therapy with Voriconazole and Liposomal Amphotericin B in a Guinea Pig Model of Invasive Aspergillosis." Antimicrobial Agents and Chemotherapy 50, no. 4 (April 2006): 1567–69. http://dx.doi.org/10.1128/aac.50.4.1567-1569.2006.

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ABSTRACT We evaluated combinations of voriconazole (VRC) and liposomal amphotericin B (L-AMB) in a guinea pig invasive aspergillosis model. Simultaneous VRC and L-AMB was most effective, although VRC monotherapy was also effective. These regimens as well as sequential L-AMB followed by VRC were more effective than L-AMB alone or VRC followed by L-AMB.

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Cordonnier, Catherine, Thomas J. Walsh, and Mark Bresnik. "Liposomal Amphotericin B (L-AMB) Is Superior to Amphotericin B Deoxycholate (AmB-d) in Preventing Breakthrough Fungal Infections in Patients with Prolonged Neutropenia and Fever: Results of a Sub-Group Analysis of an Empirical Antifungal Therapy Trial." Blood 104, no. 11 (November 16, 2004): 1336. http://dx.doi.org/10.1182/blood.v104.11.1336.1336.

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Abstract In a trial of empirical antifungal therapy in persistently febrile neutropenic patients, L-AMB was shown to be comparable in overall efficacy with significantly less nephrotoxicity and infusion-related reactions when compared to AmB-d. In addition, significantly fewer proven breakthrough invasive fungal infections (IFI) occurred in the L-AMB treatment group. (Walsh TJ, et al, NEJM1999; 340: 764–71). In order to better evaluate the maximum efficacy benefit of L-AMB in a higher risk patient subset, a sub-group analysis was performed on those patients with duration of neutropenia greater

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Baginski, Maciej, Kamil Sternal, Jacek Czub, and Edward Borowski. "Molecular modelling of membrane activity of amphotericin B, a polyene macrolide antifungal antibiotic." Acta Biochimica Polonica 52, no. 3 (August 5, 2005): 655–58. http://dx.doi.org/10.18388/abp.2005_3426.

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Amphotericin B (AmB) is a well known polyene macrolide antibiotic used to treat systemic fungal infections. Despite its toxicity AmB is still regarded as a life-saving drug. The lack of adequate knowledge of the AmB mechanism of action is a serious obstacle to efficient development of new less toxic derivatives. Complementary to various experimental approaches, computational chemistry methods were used to study AmB mechanism of action. A programme lasting for a decade, that was run by our group covered studies of: i) molecular properties of AmB and its membrane targets, ii) structure and prope

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Dong, Pu-Ting, Cheng Zong, Zeina Dagher, Jie Hui, Junjie Li, Yuewei Zhan, Meng Zhang, Michael K. Mansour, and Ji-Xin Cheng. "Polarization-sensitive stimulated Raman scattering imaging resolves amphotericin B orientation in Candida membrane." Science Advances 7, no. 2 (January 2021): eabd5230. http://dx.doi.org/10.1126/sciadv.abd5230.

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Ergosterol-targeting amphotericin B (AmB) is the first line of defense for life-threatening fungal infections. Two models have been proposed to illustrate AmB assembly in the cell membrane; one is the classical ion channel model in which AmB vertically forms transmembrane tunnel and the other is a recently proposed sterol sponge model where AmB is laterally adsorbed onto the membrane surface. To address this controversy, we use polarization-sensitive stimulated Raman scattering from fingerprint C═C stretching vibration to visualize AmB, ergosterol, and lipid in single fungal cells. Intracellul

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Vazquez, J. A., M. T. Arganoza, J. K. Vaishampayan, and R. A. Akins. "In vitro interaction between amphotericin B and azoles in Candida albicans." Antimicrobial Agents and Chemotherapy 40, no. 11 (November 1996): 2511–16. http://dx.doi.org/10.1128/aac.40.11.2511.

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The use of azole prophylaxis as a measure to prevent invasive fungal infections in high-risk patients is increasing and is now the standard of care in many institutions. Previous studies disagree on whether preexposure of Candida albicans to azoles affects their subsequent susceptibility to amphotericin B (AmB). The present in vitro study indicates that azole exposure generates a subpopulation of cells that are not affected by subsequent exposure to AmB. These cells that are phenotypically resistant to AmB tolerated by most cells not exposed to azole. The percentage of cells that convert to ph

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Yeo, Eun-Jin, Ji-Hye Ryu, Young-Suk Cho, Yang-Sook Chun, L. Eric Huang, Myung-Suk Kim, and Jong-Wan Park. "Amphotericin B blunts erythropoietin response to hypoxia by reinforcing FIH-mediated repression of HIF-1." Blood 107, no. 3 (February 1, 2006): 916–23. http://dx.doi.org/10.1182/blood-2005-06-2564.

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AbstractAmphotericin B (AmB) is widely used for treating severe systemic fungal infections. However, long-term AmB treatment is invariably associated with adverse effects such as anemia. The erythropoietin (EPO) suppression by AmB has been proposed to contribute to the development of anemia. However, the mechanism whereby EPO is suppressed remains obscure. In this study, we investigated the possibility that AmB inhibits the transcription of the EPO gene by inactivating HIF-1, which is a known key transcription factor and regulator of EPO expression. EPO mRNA levels were markedly attenuated by

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Rios Rubiras, Bernat. "Espais de fabricació comunitaris en l’educació primària: Involucrant l’alumnat de Grau en el procés de creació de projectes STEM amb espais de fabricació digital." Ciències: revista del professorat de ciències de Primària i Secundària, no. 42 (June 29, 2021): 40–45. http://dx.doi.org/10.5565/rev/ciencies.442.

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Aquest article relata una activitat desenvolupada al llarg del primer quadrimestre amb l’alumnat de 4t del Grau en Educació Primària de la Universitat Autònoma de Barcelona (UAB). Es tracta d’una activitat desenvolupada conjuntament amb l’espai de fabricació UAB OpenLabs de la facultat d’Enginyeria. L’activitat va permetre a l’alumnat guanyar confiança amb noves tecnologies com ara la talladora làser, la talladora de vinil i el disseny amb Inkscape. Al mateix temps va generar espais perquè es desenvolupessin les pràctiques inherents de l’enginyeria amb un objectiu d’impacte en l’entorn, fent d

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Magalhães, Thais Furtado Ferreira, Marliete Carvalho Costa, Rodrigo Assunção Holanda, Gabriela Freitas Ferreira, Vanessa Silva Dutra Carvalho, Gustavo Jose Cota Freitas, Noelly Queiroz Ribeiro, et al. "N-acetylcysteine reduces amphotericin B deoxycholate nephrotoxicity and improves the outcome of murine cryptococcosis." Medical Mycology 58, no. 6 (January 9, 2020): 835–44. http://dx.doi.org/10.1093/mmy/myz129.

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Abstract Cryptococcosis is a life-threatening fungal infection, and its current treatment is toxic and subject to resistance. Drug repurposing represents an interesting approach to find drugs to reduce the toxicity of antifungals. In this study, we evaluated the combination of N-acetylcysteine (NAC) with amphotericin B (AMB) for the treatment of cryptococcosis. We examined the effects of NAC on fungal morphophysiology and on the macrophage fungicidal activity 3 and 24 hours post inoculation. The therapeutic effects of NAC combination with AMB were investigated in a murine model with daily trea

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