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Journal articles on the topic 'American Standard, inc'

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Published: 4 June 2021

Last updated: 27 July 2025

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1

Barton, Bruce. "The Razor’s Edge between Performativity and Theatricality in Bluemouth Inc.’s American Standard." Canadian Theatre Review 126 (March 2006): 23–26. http://dx.doi.org/10.3138/ctr.126.003.

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My purpose has been to suggest points at which the floor cracks open and we are startled, however pleasantly, by the upsurge of the real into the magic circle where the conventions of theatricality have assured us that the real has been subdued and transcended.

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Barton, Bruce. "Still Ringing: Sounds Collaborative." Canadian Theatre Review 129 (January 2007): 25–29. http://dx.doi.org/10.3138/ctr.129.005.

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In CTR 126, I began a series of three linked articles that consider aspects of the relationship between theatricality and performativity in the work of the Toronto / New York intermedia performance ensemble, Bluemouth Inc. The first article explored the impact of the unanticipated relocation of the company’s 2005 recreation of American Standard from Pat’s Barber Shop on Toronto’s D’Arcy Street to the cavernous rehearsal space of Zero Gravity Circus in the same city’s industrial East End. The second article (in CTR 127) profiled Bluemouth Inc’.s 2005 reimaging of the performance Lenz in the evo

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Pessach, Guy. "The Legacy of Feist Revisited – A Critical Analysis of the Creativity Requirement." Israel Law Review 36, no. 1 (2002): 19–102. http://dx.doi.org/10.1017/s0021223700017891.

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One of the most significant court decisions in copyright law has been the United States Supreme Court's decision in Feist Pub., Inc. v. Rural Tel. Serv. Co., and its path-breaking approach towards the requirement of originality. The grant of copyright protection, in an intangible work, is conditioned upon the fulfillment of the prerequisite of originality. Until the Feist decision, Anglo-American copyright law had a long tradition of interpreting the requirement of originality as imposing a minimum standard of labor, skill or judgment in the production of a work that is not a copy of another w

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CARFAGNINI, MICHAEL. "Too Low a Threshold: Bilcon v Canada and the International Minimum Standard of Treatment." Canadian Yearbook of international Law/Annuaire canadien de droit international 53 (September 13, 2016): 244–77. http://dx.doi.org/10.1017/cyl.2016.17.

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AbstractTreaty obligations to afford foreign investors a minimum standard of treatment (MST) and/or fair and equitable treatment (FET) are hallmarks of international investment law. However, the relationship between such treaty-based obligations and customary international law has been the subject of considerable debate. In the North American Free Trade Agreement (NAFTA) context, the majority tribunal decision and dissenting opinion in Clayton and Bilcon of Delaware Inc. v Government of Canada (Bilcon) reflect ongoing disagreement regarding the threshold for breach of the MST under NAFTA Artic

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Zaiontz, Keren. "Archetypes, Urbanites and Bus Rides: How the “Here“ Becomes the “There“ in Bluemouth Inc.’s American Standard." Canadian Theatre Review 126 (March 2006): 83–87. http://dx.doi.org/10.3138/ctr.126.017.

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The spinning red-and-white pole outside Pat’s Barber Shop on D’Arcy Street in Toronto carries all the promise of a “clean cut“ — flat-top, military cut or shave with a straight-edge razor — fast and cheap. Inside Pat’s shop, there is more talcum powder than oxygen, and the mise en scène, consisting of yellowed walls, worn chairs and a hat rack, appears like a deteriorating illusion nesting among city hospitals, university buildings and trendy restaurants. It is precisely this incongruous setting of small-town coiffeur and modernist architecture that first attracted Bluemouth Inc., an interdisc

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Kamar, Amanda J., Meghana Doniparthi, Nhan Nhan, Ying Zhou, James A. Colton, and Eli D. Ehrenpreis. "445. Correlative Factors for State to State Differences in the Prevalence and Case Fatality Rates of SARS-CoV-2, COVID-19 Infections in the United States of America." Open Forum Infectious Diseases 7, Supplement_1 (2020): S290—S291. http://dx.doi.org/10.1093/ofid/ofaa439.638.

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Abstract Background Individual States of the USA have ethnic, economic, community health and education differences that influence the prevalence and outcomes of COVID-19 infection. We hypothesized that Statewide differences in the prevalence and fatality rates of COVID-19 infections are dependent on factors that may be determined by mathematical modeling. Methods Two separate statistical regression models were developed using COVID-19 case prevalence and case fatality rates functioning as dependent variables. We obtained data from the prevalence and deaths from COVID-19 cases for each state in

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Tunnell, Michael A., and Rebecca M. Brewster. "Energy and Emissions Impacts of Operating Higher-Productivity Vehicles." Transportation Research Record: Journal of the Transportation Research Board 1941, no. 1 (2005): 107–14. http://dx.doi.org/10.1177/0361198105194100113.

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The American Transportation Research Institute and Cummins, Inc. teamed up to investigate the energy and emissions impacts from operating commercial vehicles at weights equal to or greater than existing federal limits. Six vehicle configurations and four gross vehicle weights (GVWs) were modeled over a representative route to estimate fuel usage and corresponding tailpipe emissions. The results provide a comparative estimate of the potential energy and emission impacts from operating different vehicle configurations at various weights. When six configurations were modeled over a representative

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Cochran, David J., Barbara A. Silverstein, Deborah Berkowitz, et al. "The Proposed OSHA Standard Related to Ergonomics." Proceedings of the Human Factors and Ergonomics Society Annual Meeting 38, no. 14 (1994): 841. http://dx.doi.org/10.1177/154193129403801409.

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This roundtable discussion will be devoted to the proposed OSHA Standard related to Ergonomics which is scheduled to be published the first week in October. The discussion will be timely and important. This is a very controversial topic. The participants have been selected from different backgrounds and opinions. Barbara Silverstein is the head of the standard writing team and is on leave at OSHA in Washington, D.C. from her regular employment with the State of Washington Department of Labor and Industries. Deborah Berkowitz is the Director of Safety and Health of a national labor union (Unite

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Bilder, Robert M., Karen S. Postal, Mark Barisa, et al. "Inter Organizational Practice Committee Recommendations/Guidance for Teleneuropsychology in Response to the COVID-19 Pandemic†." Archives of Clinical Neuropsychology 35, no. 6 (2020): 647–59. http://dx.doi.org/10.1093/arclin/acaa046.

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Abstract Objective The Inter Organizational Practice Committee convened a workgroup to provide rapid guidance about teleneuropsychology (TeleNP) in response to the COVID-19 pandemic. Method A collaborative panel of experts from major professional organizations developed provisional guidance for neuropsychological practice during the pandemic. The stakeholders included the American Academy of Clinical Neuropsychology/American Board of Clinical Neuropsychology, the National Academy of Neuropsychology, Division 40 of the American Psychological Association, the American Board of Professional Neuro

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Kurian, A. W., N. M. Chun, M. A. Mills, et al. "BRCA1/2 mutations and cancer risk in Asian-Americans." Journal of Clinical Oncology 25, no. 18_suppl (2007): 10512. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.10512.

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10512 Background: There are significant differences in breast cancer epidemiology between Caucasian and Asian-Americans and even between different Asian groups. These cancer risks and associated BRCA1/2 mutation prevalence have not been well defined in Asians; BRCA1/2 mutation penetrance might differ due to different risk modifiers. We report on a case-control study of BRCA1/2 mutation prevalence and cancer risk in Asian-American women. Methods: Clinical Data Collection: Chart review from cancer genetics services of 4 North American centers with highest Asian volume. BRCA1/2 Mutation Risk Asse

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Dörr, Marcus, Stefan Richter, Siegfried Eckert, et al. "Invasive Validation of Antares, a New Algorithm to Calculate Central Blood Pressure from Oscillometric Upper Arm Pulse Waves." Journal of Clinical Medicine 8, no. 7 (2019): 1073. http://dx.doi.org/10.3390/jcm8071073.

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Background: Antares is an algorithm for pulse wave analysis (PWA) by oscillometric blood pressure (BP) monitors in order to estimate central (aortic) blood pressure (cBP). Antares aims to enable brachial cuff-based BP monitors to be type II-devices, determining absolute cBP values independently of potential peripheral BP inaccuracies. The present study is an invasive validation of the Antares algorithm in the custo screen 400. Methods: We followed entirely the 2017 ARTERY protocol for validation of non-invasive cBP devices, the 2013 American National Standards Institute, Inc./Association for t

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Citera, G., R. Jain, F. Irazoque-Palazuelos, et al. "THU0196 TOFACITINIB IN PATIENTS WITH RHEUMATOID ARTHRITIS AND INDICATIVE OF DEPRESSION AND/OR ANXIETY: A POST HOC ANALYSIS OF PHASE 3 AND PHASE 3B/4 CLINICAL TRIALS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 318–19. http://dx.doi.org/10.1136/annrheumdis-2020-eular.417.

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Background:Depression/anxiety are common in RA pts. SF-36 MCS ≤38 can identify probable major depressive disorder and/or probable generalised anxiety disorder (pMDD/pGAD) in RA pts. Tofacitinib is an oral JAK inhibitor for the treatment of RA.Objectives:To assess pMDD/pGAD prevalence in the tofacitinib RA program and efficacy by baseline (BL) pMDD/pGAD status.Methods:Data from pts receiving tofacitinib, ADA, or PBO were pooled from 5 Phase (P)3 and 1 P3b/4 trials. Demographics/BL characteristics were reported by BL pMDD/pGAD (SF-36 MCS ≤38, presence; >38, absence). Month (M)3/6/9/12 SF-36 M

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Spyropoulos, Alex C., Ron Preblick, Jackie Kwong, Melissa Lingohr-Smith, and Jay Lin. "Is Adherence to the American College of Chest Physicians Recommended Anticoagulation Treatment Duration Associated with Different Outcomes Among Patients with Venous Thromboembolism?" Blood 126, no. 23 (2015): 1126. http://dx.doi.org/10.1182/blood.v126.23.1126.1126.

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Abstract Introduction: Venous thromboembolism (VTE) represents a major clinical and economic burden. The American College of Chest Physicians (ACCP) Guideline 9th Edition on the treatment of VTE recommends a minimum duration of anticoagulation (AC) therapy depending on patient risk profiles. The objectives of this study were to evaluate the clinical and economic outcomes associated with adherence to the AC treatment duration recommendation among VTE patients in the real world setting. Methods: Adult patients (≥18 years of age) with at least 1 inpatient diagnosis or 2 outpatient diagnoses on tw

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Houghton, Raymond L., Yvonne Y. Stevens, Kathryn Hjerrild, et al. "Lateral Flow Immunoassay for Diagnosis of Trypanosoma cruzi Infection with High Correlation to the Radioimmunoprecipitation Assay." Clinical and Vaccine Immunology 16, no. 4 (2009): 515–20. http://dx.doi.org/10.1128/cvi.00383-08.

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ABSTRACT The incidence of blood donors seropositive for Trypanosoma cruzi in North America has increased with population migration and more rigorous surveillance. The United States, considered nonendemic for T. cruzi, could therefore be at risk to exposure to parasite transmission through blood or organ donations. Current tests show variable reactivity, especially with Central American sera. Here we describe the development of a lateral flow immunoassay for the rapid detection of T. cruzi infection that has a strong correlation to the radioimmunoprecipitation assay (RIPA) “gold standard” in th

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Garcia Kutzbach, A., P. Camilo Estrella, V. Khoury, et al. "AB0506 PREVALENCE AND CLINICAL CHARACTERISTICS OF SPONDYLOARTHRITIS IN CENTRAL AMERICA AND CARIBBEAN (PRECAES)." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1280.2–1281. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2775.

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Background:Spondyloarthritis (SpA) is a group of interrelated disorders: axial spondyloarthritis (Ankylosing Spondylitis [AS] /Non Radiographic Axial Spondyloarthritis [Nr-AxSpA]), psoriatic arthritis (PsA), reactive arthritis (ReA), inflammatory bowel disease-associated arthritis (IBD), and undifferentiated SpA (USpA).1Objectives:The objectives of this study were: a) to examine the epidemiology, disease subsets, and clinical characteristics of patients with SpA in Central America and the Caribbean region; and b) to describe the natural history of these conditions in their acute and chronic fo

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Huang, Wei. "Understanding Tesla's Financial Strength: Analysis of Financial Reports and DuPont Analysis." Highlights in Business, Economics and Management 6 (March 27, 2023): 250–61. http://dx.doi.org/10.54097/hbem.v6i.6325.

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Incorporated in 2003, Tesla motors, inc is a leading American automotive company named after electrical engineer and physicist Nikola Tesla. Tesla designs develop, manufactures, and sells high-end fully electric vehicles and advanced electric vehicle powertrains. Meanwhile, it has established its global selling network, service centers, and supercharger station. With a focus on sustainability and innovation, Tesla has set the standard for the industry and is leading the charge toward a brighter future. This essay will suggest the company’s history, products, and business strategy. Additionally

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Yura, Joseph A., and Karl H. Frank. "Testing Method to Determine Slip Coefficient for Coatings Used in Bolted Joints." Engineering Journal 22, no. 3 (1985): 151–55. http://dx.doi.org/10.62913/engj.v22i3.445.

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In 1975, the Steel Structures Painting Council (SSPC) contacted the Research Council on Riveted and Bolted Structural Joints (RCRBSJ), now the Research Council on Structural Connections (RCSC), regarding the difficulties and costs which steel fabricators encounter with restrictions on coatings of contact surfaces for friction-type structural joints. The SSPC also expressed the need for a "standardized test which can be conducted by any certified testing agency at the initiative and expense of any interested party, including the paint manufacturer." And finally, the RCSC was requested to "prepa

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Khalil, Fady T. A., Emad A. El Monem Areeda, Sherif Y. A. Omar, and Mohamed M. A. El Hady. "Comparison of ultrasound guided transversus abdominis plane block with bupivacaine versus levobupivacaine in cesarean section undergoing spinal anesthesia." Research and Opinion in Anesthesia & Intensive Care 12, no. 1 (2025): 28–34. https://doi.org/10.4103/roaic.roaic_36_24.

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Background Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage. Aim To compare the efficacy of ultrasound-guided transverses abdominis plane block using plain bupivacaine 0.25% and levobupivacaine 0.25% after cesarean section via spinal anesthesia. Patients and methods A randomized controlled trials study was carried out at El Shatby Hospital Alexandria University on 44 American Society of Anesthesiologists I and II adult females scheduled for elective cesarean section. The recorded data were analyzed us

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Brunner, H., H. Wasserman, M. Saul, et al. "POS0764 IMPACT OF TOFACITINIB TREATMENT ON HEIGHT IN JUVENILE IDIOPATHIC ARTHRITIS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 673.2–674. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2707.

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BackgroundDiminished growth can be a consequence of juvenile idiopathic arthritis (JIA).[1]Growth hormone signals through a Janus kinase (JAK)2 tyrosine kinase-coupled receptor.[2]Tofacitinib, an oral JAK inhibitor approved for JIA, preferentially inhibits signalling by heterodimeric receptors associated with JAK1 and/or JAK3 and has less functional selectivity for JAK2.ObjectivesTo evaluate the growth of patients (pts) with JIA treated with tofacitinib.MethodsThis post hoc analysis of the Phase 3 trial of tofacitinib in pts with JIA (NCT02592434; a 44-week, 2-part, double-blind [DB], withdraw

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Srour, Samer A., Qaiser Bashir, Denái R. Milton, et al. "Long-Term Survival for Myeloma after Autologous Stem Cell Transplantation." Blood 136, Supplement 1 (2020): 23–24. http://dx.doi.org/10.1182/blood-2020-143053.

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Introduction: Multiple myeloma (MM) remains incurable with only a small proportion of patients surviving over 10 years (long-term survivors) from diagnosis. It has been more than 3 decades since the first autologous stem cell transplantation (ASCT) was performed for MM at our institution. In this study, we sought to determine baseline patient and disease characteristics that are associated with long-term survival after the ASCT. Methods: We included all consecutive patients who received their first ASCT between January 1988 and December 2015. The primary objective was to identify the variables

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Griffin, Michael, Mevlana Gemici, Ashar Javed, et al. "Abstract 471: AIM PD-L1-NSCLC: Artificial intelligence-powered PD-L1 quantification for accurate prediction of tumor proportion score in diverse, multi-stain clinical tissue samples." Cancer Research 82, no. 12_Supplement (2022): 471. http://dx.doi.org/10.1158/1538-7445.am2022-471.

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Abstract Introduction: Important immunotherapy drugs targeting PD-L1 are approved for first and second line treatment for various stages of NSCLC. Reproducible and precise evaluation of PD-L1 expression is essential to accurately evaluate patients’ eligibility for treatment and for enrollment in clinical trials. Current guidelines rely on pathologists to interpret tumor samples, which is challenging in part because different PD-L1 assays have distinct scoring criteria. As a result, determining eligibility by manual assessment can be inconsistent and inaccurate, leading to untreated patients. T

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Singh, J., C. Adams, A. Frick, et al. "AB1825-HPR DECISION TO INITIATE A TUMOR NECROSIS FACTOR INHIBITOR IN RHEUMATOID ARTHRITIS UNCOUPLED FROM DISEASE ACTIVITY MEASURES." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 2144.2–2145. http://dx.doi.org/10.1136/annrheumdis-2023-eular.641.

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BackgroundPrevious studies have demonstrated discordance between patient-based (e.g. RAPID3) and predominantly physician-based (e.g. CDAI) disease activity measures (DAMs).ObjectivesTo examine the relationship between DAMs and decision to initiate TNFi following csDMARDs.MethodsData: PIONEER-Rheumatology, an EMR and open text-extracted database specific to care given by the American Rheumatology Network. Study population: Adult RA patients who received TNFi as initial targeted synthetic or biologic DMARD treatment between Jan 2014 to Apr 2022 after csDMARDs. Assessments: CDAI, RAPID3, DAS28 (i

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Robinson, Patricia A., Michaela L. Tsai, Shelly S. Lo, et al. "Genomic risk classification by the 70-gene signature and 21-gene assay in African American early-stage breast cancer patients." Journal of Clinical Oncology 39, no. 15_suppl (2021): e12568-e12568. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e12568.

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e12568 Background: Genomic risk of recurrence assays provide prognostic information that aids treatment recommendations for patients with early breast cancer (EBC). The 70-gene signature (MammaPrint/MP) and the 21-gene assay (Oncotype DX/ODX) were both validated by large prospective, randomized clinical trials. Previous studies have directly compared the performance of these assays, with moderate discordance widely observed. Recent work showed poor prognostic performance of the ODX in African American (AA) EBC patients (Hoskins et al., 2021). Here, we compare the concordance of two genomic tes

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Stapleton, Michelle, Jeffery Bub, and Suzette Chance. "A Ristocetin-Independent ELISA for the Measurement of VWF Activity." Blood 116, no. 21 (2010): 1411. http://dx.doi.org/10.1182/blood.v116.21.1411.1411.

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Abstract Abstract 1411 Von Willebrand Disease (VWD) is a relatively common bleeding disorder characterized by both quantitative and qualitative deficiencies in von Willebrand Factor. The correct diagnosis and classification of VWD is made on the basis of a personal and family bleeding history and the results of a panel of laboratory tests. Evaluations of both VWF antigen level and function are required. Most commonly VWF function is evaluated based on VWF binding to platelets through the platelet surface glycoprotein GPIba in a platelet aggregation assay (VWF:RCo). The VWF:RCo assay requires t

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Galaznik, Aaron, Jill A. Bell, Meredith M. Hoog, et al. "Systematic Review of Therapy Used in Relapsed or Refractory Diffuse Large B-Cell Lymphoma." Blood 128, no. 22 (2016): 3562. http://dx.doi.org/10.1182/blood.v128.22.3562.3562.

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Abstract INTRODUCTION: Non-Hodgkin's lymphoma is a heterogeneous group of diseases originating in the lymphoid system. The most common subtype, constituting up to 40% of all cases globally, is diffuse large B cell lymphoma (DLBCL).1 Approximately one-third of DLBCL patients treated with standard therapy (since 1998, a combination of chemotherapy plus immunotherapy with the CD20-directed humanized monoclonal antibody rituximab [RCHOP]) at diagnosis will develop relapsed or refractory (R/R) disease.1 Relapsed or refractory disease is defined as those whose disease does not respond to therapy (re

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LeBlanc, Thomas W., Roland B. Walter, Loriana Hernandez-Aldama, et al. "Treatment Decision Making in AML: Factors of Importance to Clinicians, AML Patients and Their Family." Blood 134, Supplement_1 (2019): 3498. http://dx.doi.org/10.1182/blood-2019-124660.

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INTRODUCTION: Acute myeloid leukemia (AML) is a rare hematologic cancer primarily affecting older people, with a median age at diagnosis of 67 years old (Almeida & Ramos, 2016). Heterogeneity in the presentation, functional status and presence of comorbidities among AML patients presents unique challenges for treatment. Intensive chemotherapy (IC), although the best option for prolonging survival, carries a risk of early death and other trade-offs, including significant time spent in the hospital. The toxicity of IC treatment and the requirement for prolonged hospitalizations may negativel

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Hart, Lowell L., and Magali Van den Bergh. "Abstract 3383: Liquid biopsy for PDL-1 status by analysis of cfRNA: Clinical data from a large community practice." Cancer Research 83, no. 7_Supplement (2023): 3383. http://dx.doi.org/10.1158/1538-7445.am2023-3383.

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Abstract PD-L1 testing via immunochemistry has become a widely used tool to predict response to immune checkpoint inhibitor (ICI) therapy in many tumor types. However this marker can be expressed heterogeneously, and can vary with time, treatment effects, and local factors including cytokine expression. Gene expression profiles of immunologically active genes are currently being studied to more accurately predict response to ICI treatment. To evaluate a potentially more straightforward way to accomplish this, we utilized an assay of cfRNA in plasma for PD-L1, utilizing a real-time PCR based as

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Helfgott, S., C. Adams, A. Frick, et al. "AB1824-HPR MULTIPLE TNFI TREATMENT CYCLES AND THE FAILURE OF TRIAL-AND-ERROR CARE FOR PATIENTS WITH RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 2144.1–2144. http://dx.doi.org/10.1136/annrheumdis-2023-eular.116.

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BackgroundInhibitors of tumor necrosis factor-alpha (TNFi) are central to management of rheumatoid arthritis (RA) though continued use beyond initial failure is negatively associated with response to subsequent TNFi treatment.ObjectivesTo assess the patterns of recurrent TNFi use relative to reasons for switch as observed in community rheumatology care in the US.MethodsData: PIONEER-Rheumatology, an EMR and open text-extracted database specific to care given by the American Rheumatology Network (ARN). Study population: Adult (18+ years old) patients with RA, TNFi-treated in 2018 to 2021. Full

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Naseri, Estephania, Fernanda Surita, Anderson Borovac-Pinheiro, Marília Santos, Simone Appenzeller, and Lilian Costallat. "Systemic Lupus Erythematosus and Pregnancy: A Single-Center Observational Study of 69 Pregnancies." Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics 40, no. 10 (2018): 587–92. http://dx.doi.org/10.1055/s-0038-1672136.

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Objective To evaluate the effects of pregnancy in systemic lupus erythematosus (SLE) patients. Methods The present article is a retrospective cohort study. Data were collected from medical records of pregnant women with SLE from January 2002 to December 2012 at Universidade Estadual de Campinas, in the city of Campinas, state of São Paulo, Brazil. Systemic lupus erythematosus and disease activity were defined according to the American College of Rheumatology and the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) criteria respectively. The means, standard deviations (SDs), percent

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Lust, John A., Saad Z. Usmani, Mehdi Hamadani, et al. "Phase 1b/2a Open-Label, Multiple-Dose, Dose-Escalation Study to Evaluate the Safety and Tolerability of SNS01-T Administered by Intravenous Infusion in Patients with Relapsed or Refractory Multiple Myeloma." Blood 120, no. 21 (2012): 2973. http://dx.doi.org/10.1182/blood.v120.21.2973.2973.

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Abstract Abstract 2973 Eukaryotic translation initiation Factor 5A (eIF5A) has been implicated in the regulation of apoptosis and is the only known protein to be modified by hypusination. Hypusinated eIF5A is the predominant form of eIF5A in cancer cells. However, in its unhypusinated form, eIF5A is pro-apoptotic. SNS01-T, designed to treat B-cell cancers, consists of two active components: a plasmid DNA expressing eIF5AK50R (human eIF5A containing a lysine to arginine substitution at position 50) which remains pro-apoptotic because it cannot be hypusinated, and an siRNA against an untranslate

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Slichter, Sherrill J., Larry J. Dumont, Jose A. Cancelas, et al. "Treatment of Bleeding in Severely Thrombocytopenic Patients with Transfusion of Dimethyl Sulfoxide (DMSO) Cryopreserved Platelets (CPP) Is Safe - Report of a Phase 1 Dose Escalation Safety Trial." Blood 128, no. 22 (2016): 1030. http://dx.doi.org/10.1182/blood.v128.22.1030.1030.

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Abstract Availability of platelets (plts) is severely limited by shelf life in some military as well as civilian settings. Additionally, some bleeding, thrombocytopenic patients do not have a therapeutic response to a standard plt transfusion. Methods for cryopreservation of apheresis plts for up to two years in 6% DMSO at <-65°C (CPP) have been developed and evaluated by in vitro assays and by in vivo infusions in non-human primates, in a few controlled human trials, and in field military operations. However, FDA has not yet approved CPP for routine use. Autologous radiolabeled CPP in heal

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Amin, Alpesh N., Nicole Princic, Jay Lin, Stephen Thompson, and Stephen Johnston. "Real-World Analysis of the Duration of Risk of Venous Thromboembolism In US Surgical Patients." Blood 116, no. 21 (2010): 479. http://dx.doi.org/10.1182/blood.v116.21.479.479.

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Abstract Abstract 479 Background: Patients hospitalized for major surgery are at significant risk of developing venous thromboembolism (VTE). In the US, the length of acute hospitalization for surgery has been decreasing. Given the decreased length of hospital stays, the time during which surgical patients are at risk for VTE is not well-understood in real-world clinical practice. Such information could provide insights into whether current recommendations regarding VTE prophylaxis reflect the real world needs. This retrospective, observational study assessed the incidence and time course of V

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Pandey, Manu, Mahesh Swaminathan, Elizabeth A. Griffiths, et al. "Outcomes of Venetoclax-Based Regimens Compared with Hypomethylating Agents (HMA) Alone or 7+3 in Elderly Patients with Newly Diagnosed Acute Myeloid Leukemia (AML): A Single Center Retrospective Analysis." Blood 134, Supplement_1 (2019): 3866. http://dx.doi.org/10.1182/blood-2019-132123.

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In the past year, there has been a paradigm shift in the treatment of elderly and/or unfit patients with newly diagnosed acute myeloid leukemia (AML) with the approval of venetoclax (Ven) plus hypomethylating agents (HMA) or low dose Ara-C (LDAC). Ven/ HMA has shown an impressive complete response + complete response with incomplete count recovery (CR+ CRi) rate of 67% and a median overall survival (OS) of 17.5 months in older patients (pts) (median age 74 years) with intermediate and poor risk cytogenetics (Dinardo C et. Blood 2019). Similarly, Ven/LDAC resulted in a CR+ CRi rate of 54% with

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Anuj, Thapar, Zalawadia Aman, V. Pokharkar Omkar, and S. Satam Sahil. "Classification of pesticides and its damaging effects: a review." Biolife 4, no. 1 (2022): 13–24. https://doi.org/10.5281/zenodo.7309647.

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<strong>ABSTRACT</strong> Organophosphate (OP) pesticides, as a group, are most widely used insecticides in India. OP pesticides are generally used on fruits, vegetables, grains, and pasture seed, cotton, on livestock and domestic animals as well as for building pest control. Pesticides compounds represent an important class of pollutants for food, soil and surface water resources. These pesticides remain in the fruits and vegetables and cannot be removed even after washing which is very harmful and affects the human health, so to remove or neutralize these harmful pesticides some alternative

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Olofsson, Christina, Torbjörn Ahl, Torsten Johansson, et al. "A Multicenter Clinical Study of the Safety and Activity of Maleimide-Polyethylene Glycol–modified Hemoglobin (Hemospan®) in Patients Undergoing Major Orthopedic Surgery." Anesthesiology 105, no. 6 (2006): 1153–63. http://dx.doi.org/10.1097/00000542-200612000-00015.

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Background Hemospan (Sangart Inc., San Diego, CA), a polyethylene glycol-modified hemoglobin with unique oxygen transport properties, has successfully completed a phase I trial in healthy volunteers. Because adverse events are expected to increase with age, the authors conducted a phase II safety study of Hemospan in elderly patients undergoing elective hip arthroplasty during spinal anesthesia. Methods Ninety male and female patients, American Society of Anesthesiologists physical status I-III, aged 50-89 yr, in six Swedish academic hospitals were randomly assigned to receive either 250 or 50

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Stoian, Dana, Bogdan Timar, Mihnea Derban, et al. "Thyroid Imaging Reporting and Data System (TI-RADS): the impact of Quantitative Strain Elastography for better stratification of cancer risks." Medical Ultrasonography 17, no. 3 (2015): 327. http://dx.doi.org/10.11152/mu.2013.2066.173.dst.

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Aims: Due to the elevated prevalence of the solid thyroid nodules in a general population, an appropriate selection of cases referred to surgery is of paramount importance. The main aim of our study was to evaluate the performance of the Thyroid Imaging Reporting and Data System (TI-RADS) as a differential diagnosis tool for thyroid nodules. Material and methods: We evaluated 174 nodules using TI-RADS risk stratification model, using conventional ultrasound and real time elastography parameters and linear multifrequency probe (Hitachi Preirus Machine, Hitachi Inc., Japan). All the nodules were

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Nongbua, T., A. Utta, N. Am-In, J. Suwimonteerabutr, A. Johannisson, and J. Morrell. "54 SINGLE LAYER CENTRIFUGATION BEFORE CRYOPRESERVATION IMPROVES BULL SPERM QUALITY." Reproduction, Fertility and Development 29, no. 1 (2017): 134. http://dx.doi.org/10.1071/rdv29n1ab54.

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Single layer centrifugation (SLC) with Bovicoll is a technique to enhance sperm quality. The purpose of this study was to investigate the effect of SLC before cryopreservation on bull sperm quality after thawing. Semen was collected from 8 bulls (American Brahman, n = 5 and Sahiwal, n = 3) at the North Eastern Bull Centre (KhonKaen, Thailand). The ejaculate was split: one part was prepared following the standard procedure at the bull centre (n = 88) as control. The other part was used for SLC with Bovicoll-B (Johannisson et al. 2016 Theriogenology 86, 140). The SLC-selected sperm samples were

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Wang, Eunice S., Elizabeth A. Griffiths, Roland B. Walter, et al. "Tolerability and Efficacy of Crenolanib and Cytarabine/Anthracycline Chemotherapy in Older Patients (Aged 61 to 75) with Newly Diagnosed FLT3-Mutated Acute Myeloid Leukemia (AML)." Blood 134, Supplement_1 (2019): 3829. http://dx.doi.org/10.1182/blood-2019-130536.

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Background: Older AML patients often present with comorbidities and may have a compromised ability to tolerate intensive chemotherapy. These patients are more likely to have AML secondary to MDS/MPN and are considered to have a biologically distinct disease compared to their younger counterparts, with more frequent occurrence of adverse-risk cytogenetic abnormalities and mutations in genes regulating epigenetic modifications. In addition, the heterogeneity of driver mutations within a single patient contributes to limited responses to standard induction chemotherapy. While FLT3 mutations occur

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SAKHNO, T. V., P. V. PISARENKO, I. V. KOROTKOVA, O. M. OMELIAN, and N. N. BARASHKOV. "THE APPLICATION OF STATISTICAL METHODS OF QUALITY MANAGEMENT BY GMP+ STANDARDS USING FERROMAGNETIC MICROTRACERS." Grain Products and Mixed Fodder’s 18, no. 3 (2018): 39–44. http://dx.doi.org/10.15673/gpmf.v18i3.1078.

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The GMP+FSA Feed Certification scheme is considered and analyzed which was developed in 1992 by the Dutch feed industry in response to various incidents involving contamination in feed materials. Currently it is an international scheme that is managed by GMP+ International in collaboration with stakeholders from numerous European countries. One of the most important and responsible steps in the feed production is mixing - creating a completely homogeneous mixture. In this paper, a statistical quality assessment of mixing of multicomponent feeds using the distribution of added particles – micro

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Jun, Hye Ryeong, Sung Hun Ju, Jung Eun Kim, et al. "Abstract 762: Organo-on-pillar based anticancer drug screening platform for ovarian cancer." Cancer Research 83, no. 7_Supplement (2023): 762. http://dx.doi.org/10.1158/1538-7445.am2023-762.

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Abstract Previously preclinical models for customized drug screening and precision oncology are being developed to replace animal models. Advances in biocompatible organoid technology have made it possible to culture cancer organoids from human tumor tissues. Cancer organoids are easy to proliferate, and large-scale drug screening platforms can be developed in that they can reproducibly repeat experiments with various concentrations of drugs. In this study, we developed automated extracellular matrix integrated, three-dimensional, patient-derived cell spotting technology and pillar-based cance

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Hooshmandi, Melika, Ashraf Mazaheri Tehrani, Majid Habibi Mohraz, Mostafa Leili, and Mohammad javad Assari. "Evaluation of Seasonal Variation on the Health Risks Using the Quantitative Microbial Risk Assessment Approach in a Wastewater Treatment Plant in Hamadan, Iran." Journal of Research in Health Sciences 23, no. 1 (2023): e00576. http://dx.doi.org/10.34172/jrhs.2023.111.

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Background: Wastewater treatment plants (WWTPs) are a source of airborne bacterial contamination that can pose health risks to staff. The aim of this study was to evaluate seasonal variations in the health risks of exposure to Staphylococcus aureus bioaerosols using the quantitative microbial risk assessment (QMRA) approach in a WWTP in Hamadan, Iran. Study Design: This was a descriptive cross-sectional study. Methods: This study determined the emission concentrations of S. aureus bioaerosols in summer and winter. Then, the health risks of three exposure scenarios (the worker, field engineer,

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Lee, Jong Yoon, Donghyun Kim, Stefanida Blake, et al. "403 Comparative Study of Wireless Sensors Versus Type III Home Sleep Apnea Test for Home-based Diagnosis of Obstructive Sleep Apnea." Sleep 44, Supplement_2 (2021): A160. http://dx.doi.org/10.1093/sleep/zsab072.402.

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Abstract Introduction More than 22 million Americans are estimated to have obstructive sleep apnea (OSA), though this disease remains perpetually underdiagnosed. Undiagnosed OSA contributes to poor clinical outcomes, large healthcare costs and an economic burden in excess of $150 billion dollars annually. While polysomnography (PSG) is considered the gold standard to diagnose OSA home sleep apnea testing (HSAT) is now used for most patient cohorts. Wireless sensors may offer a lower cost and less burdensome approach to home testing than traditional HSAT. Methods We performed a fully remote, na

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Galsky, Matt D., Andrea Necchi, Srikala S. Sridhar, et al. "A phase III, randomized, open label, multicenter, global study of first-line (1L) durvalumab in combination with standard of care (SOC) chemotherapy and durvalumab in combination with tremelimumab and SOC chemotherapy versus SOC chemotherapy alone in patients with unresectable locally advanced or metastatic urothelial cancer (UC)." Journal of Clinical Oncology 37, no. 15_suppl (2019): TPS4590. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.tps4590.

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TPS4590 Background: Despite high response rates to 1L SoC for locally advanced or metastatic UC chemotherapy (gemcitabine + cisplatin or gemcitabine + carboplatin for patients who are cisplatin-ineligible [poor performance status, impaired renal function, comorbidities]), most patients experience disease progression. Novel strategies such as combining chemotherapy and immunotherapy offer hope for improving clinical outcomes. Durvalumab is a selective, high affinity, engineered human IgG1 mAb that blocks PD-L1 binding to PD-1 and CD80. Tremelimumab is a human IgG2 mAb directed against CTLA-4. T

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Kaplan, Sheldon L., Adi Klein, Mark Kellogg, et al. "112. A Rapid Host-Protein Signature Based on TNF-related Apoptosis-Induced Ligand (TRAIL), Interferon Gamma Induced Protein-10 (IP-10) and C-Reactive Protein (CRP) Accurately Differentiates Between Bacterial and Viral Infection in Febrile Children: Apollo Sub-Study." Open Forum Infectious Diseases 8, Supplement_1 (2021): S69. http://dx.doi.org/10.1093/ofid/ofab466.112.

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Abstract Background Identifying infectious etiology is essential for appropriate patient management, including antibiotic use. A host-protein signature for differentiating bacterial from viral infection has exhibited robust performance (AUC of 0.9, 95% CI 0.86-0.95) in prior studies. Performance data was lacking for a broad pediatric population recruited in emergency departments (EDs) and urgent care centers (UCCs). Methods Non-immunocompromised children were recruited prospectively from 5 EDs and 3 UCCs in the U.S. and 1 ED in Israel between May 2019 and August 2020. Eligibility required phys

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Maxwell, Kristi, Eric A. Severson, Meagan Montesion, Ingrid Marino, Rachel Anhorn, and Bethany Sawchyn. "CGE19-064: Patient Access to Comprehensive Genomic Profiling for Hematologic Malignancies: Analysis of the Payer Coverage Landscape and Results of Testing in 3,600 Patients." Journal of the National Comprehensive Cancer Network 17, no. 3.5 (2019): CGE19–064. http://dx.doi.org/10.6004/jnccn.2018.7255.

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Comprehensive genomic profiling (CGP) for patients with advanced solid tumors is on the trajectory of becoming standard of care through incorporation into clinical practice, professional society guidelines, availability of an FDA-approved assay, and a national coverage determination from Medicare. For hematologic malignancies, the clinical utility of CGP can be diagnostic, prognostic, or predictive depending on the type of malignancy. Molecular testing has been standard of care for many years for hematologic malignancies, and payer coverage of the CGP approach must now be considered to keep pa

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Renaghan, Eric, Harrison L. Wittels, Luis A. Feigenbaum, et al. "Exposures to Elevated Core Temperatures during Football Training: The Impact on Autonomic Nervous System Recovery and Function." Sports 12, no. 1 (2023): 8. http://dx.doi.org/10.3390/sports12010008.

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Exercising with elevated core temperatures may negatively affect autonomic nervous system (ANS) function. Additionally, longer training duration under higher core temperatures may augment these negative effects. This study evaluated the relationship between exercise training duration and 24 h ANS recovery and function at ≥37 °C, ≥38 °C and ≥39 °C core temperature thresholds in a sample of male Division I (D1) collegiate American football athletes. Fifty athletes were followed over their 25-week season. Using armband monitors (Warfighter MonitorTM, Tiger Tech Solutions, Inc., Miami, FL, USA), c

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Davis, David D., Stephen Dick, Stephen Wilk, MaryClara Jones, and Yuqing Zeng. "Review of Track Inspection and Maintenance Standards for Transit." Transportation Research Record: Journal of the Transportation Research Board 2673, no. 12 (2019): 538–47. http://dx.doi.org/10.1177/0361198118825463.

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Transportation Technology Center, Inc (TTCI) reviewed rail transit track inspection and maintenance standards in North America. These agency standards were benchmarked against similar protocols existing in other parts of the world. In addition, transit agencies were surveyed to document inspection, maintenance, and operating practices to understand variations in inspection and maintenance standards. Approximately 30 agencies participated in the survey which establishes a significant representative sample of North American transit operations. An analysis of track-related accidents was conducted

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Ikeda, Masafumi, Nobuaki Matsubara, Chihiro Kondoh, et al. "Abstract CT177: A phase I, first in human study of CBA-1205, glycoengineered humanized anti-DLK-1 monoclonal antibody in patients with advanced solid tumors." Cancer Research 83, no. 8_Supplement (2023): CT177. http://dx.doi.org/10.1158/1538-7445.am2023-ct177.

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Abstract Background: CBA-1205 is a novel humanized anti-delta-like 1 homolog (DLK-1) antibody. It is a glycoengineered antibody by GlymaxX® technology to potentiate antibody-dependent cellular cytotoxicity activity. DLK-1 is a membrane protein with 6 tandem EGF-like motifs in extracellular region. Overexpression of DLK-1 has been reported in variety of cancer types including hepatocellular carcinoma (HCC), suggesting that DLK-1 could be an ideal target for cancer therapy. Methods: This is a first in human, multicenter, open-label Phase I study. The purpose of part 1 is to evaluate the safety a

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Flannagan, Lauryn Elise, Michela Cadarso, Eleanor Riedl, Md Shahadat Hossan, Ethan S. Lin, and Jeremy D. Kratz. "Abstract 2941: Physiologic epidermal growth factor modeling improves sensitivity of KRASG12Dinhibitor MRTX1133." Cancer Research 85, no. 8_Supplement_1 (2025): 2941. https://doi.org/10.1158/1538-7445.am2025-2941.

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Abstract Background: Pancreatic Ductal Adenocarcinoma (PDAC) remains a formidable cancer type with a median 5-year survival rate of 13%, largely due to ineffective systemic therapy. MRTX1133 is an emerging small molecule inhibitor of KRASG12D which has been shown to be effective across multiple treatment settings. Epidermal growth factor (EGF) is often integrated at supraphysiologic levels in models of luminal cancer types. Here, we evaluate KRASG12D targeting as a function of EGF supplementation to understand both sensitivity and selectivity across EGFR signaling. Methods: Organoids were seed

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Lu, Li-Chun, Yi-Hsuan Lee, Tsung-hao Liu, Yu-Yun Shao, Ann-Lii Cheng, and Chih-Hung Hsu. "Abstract 1526: The distinct tumor microenvironment of advanced hepatocellular carcinoma with high PVR or high PD-L1 expression." Cancer Research 84, no. 6_Supplement (2024): 1526. http://dx.doi.org/10.1158/1538-7445.am2024-1526.

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Abstract Background: The combination of anti-PD-L1 and anti-VEGF has been the standard-of-care for advanced hepatocellular carcinoma (HCC), while additionally targeting TIGIT is under active investigation. We aimed to explore the expression and clinical significance of PVR (CD155), the ligand of TIGIT, within the tumor microenvironment (TME) of advanced HCC. Methods: All HCC tumor specimens were obtained at the advanced stage of HCC. Immunohistochemistry (IHC) was employed to evaluate membranous staining of PVR and PD-L1 of tumor specimens, and semiquantitative scores with IHC 0, 1, 2, or 3 we

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