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1

V. Komarov, Igor, Aleksandr Yu. Ishchenko, Aleksandr Hovtvianitsa, et al. "Fast Amide Bond Cleavage Assisted by a Secondary Amino and a Carboxyl Group—A Model for yet Unknown Peptidases?" Molecules 24, no. 3 (2019): 572. http://dx.doi.org/10.3390/molecules24030572.

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Unconstrained amides that undergo fast hydrolysis under mild conditions are valuable sources of information about how amide bonds may be activated in enzymatic transformations. We report a compound possessing an unconstrained amide bond surrounded by an amino and a carboxyl group, each mounted in close proximity on a bicyclic scaffold. Fast amide hydrolysis of this model compound was found to depend on the presence of both the amino and carboxyl functions, and to involve a proton transfer in the rate-limiting step. Possible mechanisms for the hydrolytic cleavage and their relevance to peptide
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2

Wójcik, J., K. Ruszczyńska, I. Zhukov, and A. Ejchart. "NMR measurements of proton exchange between solvent and peptides and proteins." Acta Biochimica Polonica 46, no. 3 (1999): 651–63. http://dx.doi.org/10.18388/abp.1999_4137.

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Scope and limitations of the NMR based methods, equilibration and magnetization transfer, for measuring proton exchange rates of amide protons in peptides and proteins with water protons are discussed. Equilibration is applied to very slow processes detected by hydrogen-deuterium exchange after a solute is dissolved in D2O. Magnetization transfer allows to study moderately rapid processes in H2O. A number of precautions should be undertaken in order to avoid systemic errors inherent in the magnetization transfer method.
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3

Song, Qingxu, Chencheng Zhang, Xin Chen, and Yufeng Cheng. "Comparing amide proton transfer imaging with dynamic susceptibility contrast-enhanced perfusion in predicting histological grades of gliomas: a meta-analysis." Acta Radiologica 61, no. 4 (2019): 549–57. http://dx.doi.org/10.1177/0284185119871667.

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Background As a subtype of chemical exchange saturation transfer imaging without contrast agent administration, amide proton transfer (APT) imaging has demonstrated the potential for differentiating the histologic grades of gliomas. Dynamic susceptibility contrast-enhanced perfusion, a perfusion-weighted imaging technique, is a well-established technique in grading gliomas. Purpose To compare the ability of amide proton transfer and dynamic susceptibility contrast-enhanced imaging for predicting the grades of gliomas. Material and Methods A comprehensive literature search was performed indepen
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4

Dai, Z., G. Yan, S. Li, et al. "Optimized amide proton transfer imaging of ischemic stroke." Journal of the Neurological Sciences 333 (October 2013): e234. http://dx.doi.org/10.1016/j.jns.2013.07.914.

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5

Tang, Guo Qing, Jean MacInnis, and Michael Kasha. "Proton-transfer spectroscopy of benzanilide. Amide-imidol tautomerism." Journal of the American Chemical Society 109, no. 8 (1987): 2531–33. http://dx.doi.org/10.1021/ja00242a058.

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6

Law, Benjamin King Hong, Ann D. King, Qi-Yong Ai, et al. "Head and Neck Tumors: Amide Proton Transfer MRI." Radiology 288, no. 3 (2018): 782–90. http://dx.doi.org/10.1148/radiol.2018171528.

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7

Ji, Chong-Lei, Pei-Pei Xie, and Xin Hong. "Computational Study of Mechanism and Thermodynamics of Ni/IPr-Catalyzed Amidation of Esters." Molecules 23, no. 10 (2018): 2681. http://dx.doi.org/10.3390/molecules23102681.

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Nickel catalysis has shown remarkable potential in amide C–N bond activation and functionalization. Particularly for the transformation between ester and amide, nickel catalysis has realized both the forward (ester to amide) and reverse (amide to ester) reactions, allowing a powerful approach for the ester and amide synthesis. Based on density functional theory (DFT) calculations, we explored the mechanism and thermodynamics of Ni/IPr-catalyzed amidation with both aromatic and aliphatic esters. The reaction follows the general cross-coupling mechanism, involving sequential oxidative addition,
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8

Zheng, Yang, Xiaoming Wang, and Xuna Zhao. "Magnetization Transfer and Amide Proton Transfer MRI of Neonatal Brain Development." BioMed Research International 2016 (2016): 1–11. http://dx.doi.org/10.1155/2016/3052723.

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Purpose.This study aims to evaluate the process of brain development in neonates using combined amide proton transfer (APT) imaging and conventional magnetization transfer (MT) imaging.Materials and Methods.Case data were reviewed for all patients hospitalized in our institution’s neonatal ward. Patients underwent APT and MT imaging (a single protocol) immediately following the routine MR examination. Single-slice APT/MT axial imaging was performed at the level of the basal ganglia. APT and MT ratio (MTR) measurements were performed in multiple brain regions of interest (ROIs). Data was statis
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Sun, Phillip Zhe, Jinyuan Zhou, Weiyun Sun, Judy Huang, and Peter C. M. van Zijl. "Suppression of lipid artifacts in amide proton transfer imaging." Magnetic Resonance in Medicine 54, no. 1 (2005): 222–25. http://dx.doi.org/10.1002/mrm.20530.

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10

Zong, Xiaopeng, Ping Wang, Seong-Gi Kim, and Tao Jin. "Sensitivity and Source of Amine-Proton Exchange and Amide-Proton Transfer Magnetic Resonance Imaging in Cerebral Ischemia." Magnetic Resonance in Medicine 71, no. 1 (2013): 118–32. http://dx.doi.org/10.1002/mrm.24639.

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11

Kaloo, Masood Ayoub. "Anion Recognition Via polarized –N-H Fragments." JOURNAL OF ADVANCES IN CHEMISTRY 15, no. 2 (2018): 6311–12. http://dx.doi.org/10.24297/jac.v15i2.7963.

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Hydrogen bonding interaction and or proton transfer assets of synthetic molecules in presence of anionic species is pretty fascinating in the field of supramolecular analytical chemistry. Not only amide or urea based derivatives have appeared in the highlights, rather from last few decades, polarized free amine fragments (-NH2) have been brought under the study with prompt signaling. In this report, I will be focusing on the basic aspects which trigger free amine group to decode rapid anion recognition not only under organic media, but also under aqueous conditions in diverse environments.
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12

Chappell, Michael A., Manus J. Donahue, Yee Kai Tee, et al. "Quantitative Bayesian model-based analysis of amide proton transfer MRI." Magnetic Resonance in Medicine 70, no. 2 (2012): 556–67. http://dx.doi.org/10.1002/mrm.24474.

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13

Jones, Craig K., Michael J. Schlosser, Peter C. M. van Zijl, Martin G. Pomper, Xavier Golay, and Jinyuan Zhou. "Amide proton transfer imaging of human brain tumors at 3T." Magnetic Resonance in Medicine 56, no. 3 (2006): 585–92. http://dx.doi.org/10.1002/mrm.20989.

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14

Zhou, Jinyuan, Bachchu Lal, David A. Wilson, John Laterra, and Peter C. M. van Zijl. "Amide proton transfer (APT) contrast for imaging of brain tumors." Magnetic Resonance in Medicine 50, no. 6 (2003): 1120–26. http://dx.doi.org/10.1002/mrm.10651.

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15

Wang, Hongyu. "Chiral Phase-Transfer Catalysts with Hydrogen Bond: A Powerful Tool in the Asymmetric Synthesis." Catalysts 9, no. 3 (2019): 244. http://dx.doi.org/10.3390/catal9030244.

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Asymmetric phase-transfer catalysis has been widely applied into organic synthesis for efficiently creating chiral functional molecules. In the past decades, chiral phase-transfer catalysts with proton donating groups are emerging as an extremely significant strategy in the design of novel catalysts, and a large number of enantioselective reactions have been developed. In particular, the proton donating groups including phenol, amide, and (thio)-urea exhibited unique properties for cooperating with the phase-transfer catalysts, and great advances on this field have been made in the past few ye
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16

Zu, Zhongliang, Junzhong Xu, Hua Li, et al. "Imaging amide proton transfer and nuclear overhauser enhancement using chemical exchange rotation transfer (CERT)." Magnetic Resonance in Medicine 72, no. 2 (2013): 471–76. http://dx.doi.org/10.1002/mrm.24953.

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17

Bohara, Manisha, Kiyohisa Kamimura, Masanori Nakajo, Tomohide Yoneyama, and Takashi Yoshiura. "Amide Proton Transfer Imaging of Cavernous Malformation in the Cavernous Sinus." Magnetic Resonance in Medical Sciences 18, no. 2 (2019): 109–10. http://dx.doi.org/10.2463/mrms.ci.2017-0160.

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18

Joo, Bio, Kyunghwa Han, Yoon Seong Choi, et al. "Amide proton transfer imaging for differentiation of benign and atypical meningiomas." European Radiology 28, no. 1 (2017): 331–39. http://dx.doi.org/10.1007/s00330-017-4962-1.

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19

Msayib, Y., G. W. J. Harston, Y. K. Tee, et al. "Quantitative CEST imaging of amide proton transfer in acute ischaemic stroke." NeuroImage: Clinical 23 (2019): 101833. http://dx.doi.org/10.1016/j.nicl.2019.101833.

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20

Nishie, Akihiro, Yukihisa Takayama, Yoshiki Asayama, et al. "Amide proton transfer imaging can predict tumor grade in rectal cancer." Magnetic Resonance Imaging 51 (September 2018): 96–103. http://dx.doi.org/10.1016/j.mri.2018.04.017.

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21

Jia, Guang, Ronney Abaza, JoAnna D. Williams, et al. "Amide proton transfer MR imaging of prostate cancer: A preliminary study." Journal of Magnetic Resonance Imaging 33, no. 3 (2011): 647–54. http://dx.doi.org/10.1002/jmri.22480.

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22

Salhotra, Amandeep, Bachchu Lal, John Laterra, Phillip Zhe Sun, Peter C. M. van Zijl, and Jinyuan Zhou. "Amide proton transfer imaging of 9L gliosarcoma and human glioblastoma xenografts." NMR in Biomedicine 21, no. 5 (2008): 489–97. http://dx.doi.org/10.1002/nbm.1216.

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23

Wu, Yin, Yinsheng Chen, Yiying Zhao, et al. "Direct radiofrequency saturation corrected amide proton transfer tumor MRI at 3T." Magnetic Resonance in Medicine 81, no. 4 (2018): 2710–19. http://dx.doi.org/10.1002/mrm.27562.

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24

Persson, Filip, and Bertil Halle. "How amide hydrogens exchange in native proteins." Proceedings of the National Academy of Sciences 112, no. 33 (2015): 10383–88. http://dx.doi.org/10.1073/pnas.1506079112.

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Amide hydrogen exchange (HX) is widely used in protein biophysics even though our ignorance about the HX mechanism makes data interpretation imprecise. Notably, the open exchange-competent conformational state has not been identified. Based on analysis of an ultralong molecular dynamics trajectory of the protein BPTI, we propose that the open (O) states for amides that exchange by subglobal fluctuations are locally distorted conformations with two water molecules directly coordinated to the N–H group. The HX protection factors computed from the relative O-state populations agree well with expe
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25

La Penna, Giovanni, and Fabrizio Machetti. "Understanding the Exceptional Properties of Nitroacetamides in Water: A Computational Model Including the Solvent." Molecules 23, no. 12 (2018): 3308. http://dx.doi.org/10.3390/molecules23123308.

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Proton transfer in water involving C–H bonds is a challenge and nitro compounds have been studied for many years as good examples. The effect of substituents on acidity of protons geminal to the nitro group is exploited here with new p K a measurements and electronic structure models, the latter including explicit water environment. Substituents with the amide moiety display an exceptional combination of acidity and solubility in water. In order to find a rationale for the unexpected p K a changes in the (ZZ ′ )NCO- substituents, we measured and modeled the p K a with Z=Z ′ =H and Z=Z ′ =methy
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26

Colognesi, Daniele, Antonino Pietropaolo, Aníbal Javier Ramírez-Cuesta, Michele Catti, Angelo Claudio Nale, and Marco Zoppi. "Proton Vibrations in Lithium Imide and Amide Studied through Incoherent Inelastic Neutron Scattering." Advances in Science and Technology 72 (October 2010): 158–63. http://dx.doi.org/10.4028/www.scientific.net/ast.72.158.

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Lithium imide (Li2NH) and amide (LiNH2) belong to the Li-H-N system, which has been recently considered for on-board hydrogen storage applications. However the imide low-temperature crystal structure is still highly controversial, with at least six options compatible with the diffraction experimental findings. A complementary study on low-temperature Li2NH and LiNH2 has been recently accomplished by the authors using neutron spectroscopy (with energy transfer in the 3-500 meV range). The rationale of these measurements was that crystal structures (especially their proton arrangements) affect i
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27

Jeong, Ha-Kyu, Kyunghwa Han, Jinyuan Zhou, et al. "Characterizing amide proton transfer imaging in haemorrhage brain lesions using 3T MRI." European Radiology 27, no. 4 (2016): 1577–84. http://dx.doi.org/10.1007/s00330-016-4477-1.

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28

Yamashita, Shinji, Minako Azuma, Kiyotaka Saito, Takashi Watanabe, Kiyotaka Yokogami, and Hideo Takeshima. "NI-10 AVAILABILITY OF AMIDE PROTON TRANSFER-WEIGHTED MRI METRICS IN GLIOMA." Neuro-Oncology Advances 1, Supplement_2 (2019): ii27. http://dx.doi.org/10.1093/noajnl/vdz039.123.

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Abstract OBJECTIVE Chemical exchange saturation transfer (CEST) is a novel MR imaging contrast technique that relies on the molecular characteristics of the sample. Amide proton transfer (APT) imaging is an emerging CEST-based MR imaging technique that is sensitive to mobile proteins and peptides in the tissue. APT imaging has become increasingly recognized as a promising imaging modality for glioma. Several reports suggest that APT signals are a promising imaging biomarker for glioma grading and prediction of molecular marker status. In this study, we assessed the utility of APT imaging in gl
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29

Zhang, Hong, Wenzhu Wang, Shanshan Jiang, et al. "Amide proton transfer-weighted MRI detection of traumatic brain injury in rats." Journal of Cerebral Blood Flow & Metabolism 37, no. 10 (2017): 3422–32. http://dx.doi.org/10.1177/0271678x17690165.

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The purpose of this study was to explore the capability and uniqueness of amide proton transfer-weighted (APTw) imaging in the detection of primary and secondary injury after controlled cortical impact (CCI)-induced traumatic brain injury (TBI) in rats. Eleven adult rats had craniotomy plus CCI surgery under isoflurane anesthesia. Multi-parameter MRI data were acquired at 4.7 T, at eight time points (1, 6 h, and 1, 2, 3, 7, 14, and 28 days after TBI). At one and six hours post-injury, average APTw signal intensities decreased significantly in the impacted and peri-lesional areas due to tissue
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30

Togao, O., T. Yoshiura, J. Keupp, et al. "Amide proton transfer imaging of adult diffuse gliomas: correlation with histopathological grades." Neuro-Oncology 16, no. 3 (2013): 441–48. http://dx.doi.org/10.1093/neuonc/not158.

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31

Hectors, Stefanie J. C. G., Igor Jacobs, Gustav J. Strijkers, and Klaas Nicolay. "Amide proton transfer imaging of high intensity focused ultrasound-treated tumor tissue." Magnetic Resonance in Medicine 72, no. 4 (2013): 1113–22. http://dx.doi.org/10.1002/mrm.25000.

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32

Sun, Phillip Zhe, Jinyuan Zhou, Judy Huang, and Peter van Zijl. "Simplified quantitative description of amide proton transfer (APT) imaging during acute ischemia." Magnetic Resonance in Medicine 57, no. 2 (2007): 405–10. http://dx.doi.org/10.1002/mrm.21151.

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33

Blakeley, J. O., X. Ye, M. Lim, et al. "The role of amide proton transfer imaging in detecting active malignant glioma." Journal of Clinical Oncology 29, no. 15_suppl (2011): 2024. http://dx.doi.org/10.1200/jco.2011.29.15_suppl.2024.

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Wang, Rui, Sa-Ying Li, Min Chen та ін. "Amide Proton Transfer Magnetic Resonance Imaging of Alzheimerʼs Disease at 3.0 Tesla". Chinese Medical Journal 128, № 5 (2015): 615–19. http://dx.doi.org/10.4103/0366-6999.151658.

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35

Schmidt, Holger, Nina F. Schwenzer, Sergios Gatidis, et al. "Systematic Evaluation of Amide Proton Chemical Exchange Saturation Transfer at 3 T." Investigative Radiology 51, no. 10 (2016): 635–46. http://dx.doi.org/10.1097/rli.0000000000000292.

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36

Qamar, Sahrish, Ann D. King, Qi-Yong H. Ai, et al. "Pre-treatment amide proton transfer imaging predicts treatment outcome in nasopharyngeal carcinoma." European Radiology 30, no. 11 (2020): 6339–47. http://dx.doi.org/10.1007/s00330-020-06985-5.

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37

Sakata, Akihiko, Tomohisa Okada, Akira Yamamoto, et al. "Grading glial tumors with amide proton transfer MR imaging: different analytical approaches." Journal of Neuro-Oncology 122, no. 2 (2015): 339–48. http://dx.doi.org/10.1007/s11060-014-1715-8.

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38

Lamotte-Brasseur, J., G. Dive, O. Dideberg, P. Charlier, J. M. Frère та J. M. Ghuysen. "Mechanism of acyl transfer by the class A serine β-lactamase of Streptomyces albus G". Biochemical Journal 279, № 1 (1991): 213–21. http://dx.doi.org/10.1042/bj2790213.

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Optimization by energy minimization of stable complexes occurring along the pathway of hydrolysis of benzylpenicillin and cephalosporin C by the Streptomyces albus G beta-lactamase has highlighted a proton shuttle that may explain the catalytic mechanism of the beta-lactamases of class A. Five residues, S70, S130, N132, T235 and A237, are involved in ligand binding. The gamma-OH group of T235 and, in the case of benzylpenicillin, the gamma-OH group of S130 interact with the carboxylate group, on one side of the ligand molecule. The side-chain NH2 group of N132 and the carbonyl backbone of A237
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39

Bisdas, Sotirios, Stefano Casagranda, Diana Roettger, Sebastian Brandner, Lewis Thorne, and Laura Mancini. "Amide proton transfer MRI can accurately stratify gliomas according to their IDH mutation and 1p/19q co-deletion status." Journal of Clinical Oncology 38, no. 15_suppl (2020): 2561. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.2561.

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2561 Background: Amide proton transfer (APT) MRI provides sensitive metrics at the amides and amines offsets from the water resonance and has been shown in small cohorts to differentiate low from high grade gliomas with better diagnostic performance than diffusion- and perfusion-weighted MRI. The purpose of our study was to assess APT-MRI performance to stratify gliomas according to their IDH mutation and 1p/19q status. Methods: Forty-five patients with primary gliomas and diffuse astrocytomas (26 WHO grade II, 11 WHO grade III, 8 WHO grade IV) underwent prospectively multi-parametric MRI with
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40

Zhang, Hong, Huiying Kang, Xuna Zhao, et al. "Amide Proton Transfer (APT) MR imaging and Magnetization Transfer (MT) MR imaging of pediatric brain development." European Radiology 26, no. 10 (2016): 3368–76. http://dx.doi.org/10.1007/s00330-015-4188-z.

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41

Andreas, Loren B., Kristaps Jaudzems, Jan Stanek, et al. "Structure of fully protonated proteins by proton-detected magic-angle spinning NMR." Proceedings of the National Academy of Sciences 113, no. 33 (2016): 9187–92. http://dx.doi.org/10.1073/pnas.1602248113.

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Protein structure determination by proton-detected magic-angle spinning (MAS) NMR has focused on highly deuterated samples, in which only a small number of protons are introduced and observation of signals from side chains is extremely limited. Here, we show in two fully protonated proteins that, at 100-kHz MAS and above, spectral resolution is high enough to detect resolved correlations from amide and side-chain protons of all residue types, and to reliably measure a dense network of 1H-1H proximities that define a protein structure. The high data quality allowed the correct identification of
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42

Smith, Graham, and Urs D. Wermuth. "Three-dimensional hydrogen-bonded structures in the hydrated proton-transfer salts of isonipecotamide with the dicarboxylic oxalic and adipic acid homologues." Acta Crystallographica Section C Crystal Structure Communications 69, no. 10 (2013): 1192–95. http://dx.doi.org/10.1107/s010827011302430x.

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The structures of the 1:1 hydrated proton-transfer compounds of isonipecotamide (piperidine-4-carboxamide) with oxalic acid, 4-carbamoylpiperidinium hydrogen oxalate dihydrate, C6H13N2O+·C2HO4−·2H2O, (I), and with adipic acid, bis(4-carbamoylpiperidinium) adipate dihydrate, 2C6H13N2O+·C6H8O42−·2H2O, (II), are three-dimensional hydrogen-bonded constructs involving several different types of enlarged water-bridged cyclic associations. In the structure of (I), the oxalate monoanions give head-to-tail carboxylic acid O—H...Ocarboxylhydrogen-bonding interactions, formingC(5) chain substructures whi
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43

Zhang, Zewen, Caiqing Zhang, Jian Yao, et al. "Protein-based amide proton transfer-weighted MR imaging of amnestic mild cognitive impairment." NeuroImage: Clinical 25 (2020): 102153. http://dx.doi.org/10.1016/j.nicl.2019.102153.

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44

Shirota, Masami, Masayuki Nitta, Takashi Maruyama, et al. "NI-19 USEFULNESS OF AMIDE PROTON TRANSFER IMAGE IN IMAGING DIAGNOSIS OF GLIOMA." Neuro-Oncology Advances 1, Supplement_2 (2019): ii29. http://dx.doi.org/10.1093/noajnl/vdz039.130.

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Abstract INTRODUCTION APT image is one of the imaging methods in MRI, and it is a molecular image that images the concentration of an amide group having an amino acid increasing in a tumor, and is expected to be clinically applied in the imaging diagnosis of glioma. on the other hand, MET-PET is useful for diagnosis of glioma because it is well accumulated in tumor cells. Based on the results of pathological diagnosis, we compared the two and verified that APT image is useful. METHOD The study included 36 patients who underwent APT image and MET-PET. (Glioma WHO2016 Grade:GII/III/IV,and Pseudo
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45

Simpkins, Nigel S. "ChemInform Abstract: Enantioselective Proton Transfer Chemistry: Asymmetric Synthesis with Chiral Lithium Amide Bases." ChemInform 31, no. 30 (2010): no. http://dx.doi.org/10.1002/chin.200030288.

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46

Zu, Zhongliang, Vaibhav A. Janve, Ke Li, Mark D. Does, John C. Gore, and Daniel F. Gochberg. "Multi-angle ratiometric approach to measure chemical exchange in amide proton transfer imaging." Magnetic Resonance in Medicine 68, no. 3 (2011): 711–19. http://dx.doi.org/10.1002/mrm.23276.

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47

Sun, Phillip Zhe, Yoshihiro Murata, Jie Lu, Xiaoying Wang, Eng H. Lo, and A. Gregory Sorensen. "Relaxation-compensated fast multislice amide proton transfer (APT) imaging of acute ischemic stroke." Magnetic Resonance in Medicine 59, no. 5 (2008): 1175–82. http://dx.doi.org/10.1002/mrm.21591.

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48

Zhou, Jinyuan, Jaishri O. Blakeley, Jun Hua, et al. "Practical data acquisition method for human brain tumor amide proton transfer (APT) imaging." Magnetic Resonance in Medicine 60, no. 4 (2008): 842–49. http://dx.doi.org/10.1002/mrm.21712.

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49

Walker-Samuel, Simon, S. Peter Johnson, Barbara Pedley, Mark F. Lythgoe, and Xavier Golay. "Extracranial measurements of amide proton transfer using exchange-modulated point-resolved spectroscopy (EXPRESS)." NMR in Biomedicine 25, no. 6 (2011): 829–34. http://dx.doi.org/10.1002/nbm.1798.

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50

Klomp, Dennis W. J., Adrienne N. Dula, Lori R. Arlinghaus, et al. "Amide proton transfer imaging of the human breast at 7T: development and reproducibility." NMR in Biomedicine 26, no. 10 (2013): 1271–77. http://dx.doi.org/10.1002/nbm.2947.

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