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Dissertations / Theses on the topic 'Amin, Idi'

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Published: 4 June 2021
Last updated: 2 February 2022

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1

Lara, Sara Veloso. "No limiar do ethos do enunciador e do ator do enunciado no drama político O último rei da Escócia e no documentário-verdade General Idi Amin Dada: um autorretrato." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/8/8147/tde-29062015-145116/.

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Nesta dissertação, investimos na depreensão e no cotejo dos ethé das instâncias dos enunciadores e dos atores do enunciado de duas totalidades fílmicas: o subgênero drama político, O último rei da Escócia, dirigido pelo norte-americano, Kevin MacDonald, em 2006, e o documentário-verdade, General Idi Amin Dada: um autorretrato, dirigido pelo francês Barbet Schroeder, em 1974, na perspectiva da Semiótica francesa. Os enunciadores correspondem ao simulacro de sujeito dos cineastas, em conjunção com roteiristas, operadores de iluminação e de som; e os atores do enunciado correspondem ao simulacro de sujeito de Idi Amin Dada nos filmes. Entende-se o ethos na visada da Semiótica narrativa e discursiva, como um modo recorrente de fazer e ser, depreensível por meio de um percurso gerativo de sentido. As ações dos sujeitos ligadas ao fazer oscilam devido à influência das grandezas, intensidade e extensidade, que os aspectualizam, por meio do olhar do observador, representado pelos espectadores, cujas percepções são temporalizadas, controladas pelo andamento, princípios advindos da Semiótica tensiva. Os ethé dos enunciadores estão diretamente relacionados aos recursos fílmicos: tipos de plano, enquadramentos, tipos de ângulo, movimentos de câmara, iluminação, efeitos sonoros. Todos esses elementos também participam da composição dos ethé dos atores, acrescidos dos elementos corporais, como: gestos, expressão facial, olhar e forma de se mover no espaço. Pautando-nos nos trabalhos de Yuri Lotman (1978), Greimas e Courtès (1979; 2008), Elizabeth Harkot-de-La-Taille (2004; 2008), Norma Discini de Campos (2009; 2006) e Fiorin (2008), analisamos os recursos fílmicos e gestuais, cujas significações erigem da combinação do plano do conteúdo e do plano da expressão, submetidos à percepção dos espectadores. Para tanto, elencamos três cenas emblemáticas de cada filme. Primeiramente, nós as cotejamos separadamente em cada obra, a fim de verificar a possibilidade de convergência ou divergência entre o ethos do enunciador e o do ator do enunciado. Em seguida, cotejamos os dois filmes, a fim de verificar o grau de convergência ou divergência entre os ethé dos enunciadores e entre atores com os estilos dos subgêneros.
In this dissertation, we observe and compare the ethos of the enunciators and the actors of enunciation of two movie subgenres: the political drama The last king of Scotland, directed by the North American filmmaker Kevin McDonald (2006), and the documentary General Idi Amin Dada: a selfportrait (1974), directed by the French filmmaker Barbet Schroeder, from the perspective of French Semiotics. The enunciators correspond to the simulacrum of the subjects responsible for the movie: filmmakers, screen players, sound editor, photography etc; and the actors of the enunciation correspond to the subject Idi Amin Dada. Ethos in the perspective of narrative and discursive semiotics is understood as resulting from repetitive ways of doing and being, which are recognized in the generative process of meaning. The actions of the actors, which are related to the way of doing, vary according to the influence of two valencies: intensity and extensity, which aspectualize them through the viewers gaze, represented by the spectators, whose perceptions are time-measured and controlled by the pacing, principle derived from tensive Semiotics. The ethos of the enunciators is apprehended from the filmic elements: types of plan, framing, angle, camera movements, lighting, sound effects and body elements: gestures, facial expression, gaze and movement in space. Based on the works of Yuri Lotman (1978), Greimas and Courtès (1979), Elizabeth Harkot de-La-Taille (2004), Norma Discini de Campos (2009; 2006), Fiorin (2004; 2008), we perform an analysis of filmic and gestural features of three emblematic scenes in each movie, whose meanings come from the combination of the content and the expression plan submitted to the perception of viewers. Firstly, we compare them separately in order to verify the possibility of convergence or divergence between the ethos of the enunciator and the actor. Then we compare both films in order to verify the degree of convergence or divergence between the ethos of enunciators and the style of each subgenre.
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2

Bernier-Duchaussoy, Maryse. "L'Ouganda du général Idi Amin Dada de 1971-1979 : une étude comparative des approches du London Times et du Guardian." Master's thesis, Université Laval, 2020. http://hdl.handle.net/20.500.11794/67502.

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Le mémoire qui suit a pour objectif de faire ressortir les grandes lignes du traitement de la prise de pouvoir d’Amin, de la crise de la déportation des Asiatiques ainsi que de la rupture des liens diplomatiques entre la Grande-Bretagne et l’Ouganda telles que vues par le London Times et le Guardian. Il s’attardera également sur les divergences et les convergences entre les deux médias. Dans la mesure où elles sont assez distinctes pour représenter des approches à part entière, elle essaiera d’identifier les éléments qui influencent/structurent ces différentes approches en référence aux thèmes mentionnés auparavant.
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3

Bruce-Lockhart, Katherine deVries. "Imagining modernity in the Uganda Prisons Service, 1945-1979." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/269035.

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This dissertation is a social history of the Uganda Prisons Service in the late colonial and early post-colonial periods. Focusing particularly on prison officers, it advances four key arguments. Firstly, it argues that global visions of the prison were crucial in shaping the Service’s development, its institutional culture, and the professional identities of its personnel. From the late colonial period onwards, this vision was anchored on notions of penal welfarism, which positioned the prison as a centre of rehabilitation, staffed by professionals who possessed technical expertise. Secondly, the penal welfare model was combined with an emphasis on the prison’s role as a driver of economic development and a source of public revenue – features that were seen as compatible with penal modernity. Thirdly, this vision of the prison gave the Service a particular imaginative capital, which prison officers used as an important resource. It provided them with a common set of principles and norms through which to define their professional role. Senior officers adopted it with alacrity, pursuing further professionalization through engagement with transnational penal reform networks. Others summoned it as a source of claim-making, using it to call on the state to provide them with greater benefits and treat them as respectable public servants. Finally, visions of penal modernity and professionalism were contested throughout the periods under study, leading officers to engage in boundary work. Officers were regularly defining their role in relation to other spaces of incarceration, such as local government prisons and informal detention sites. With the take-over of Idi Amin in 1971 and the militarization of the state, prison officers’ professional identities were profoundly challenged, but also became particularly important, providing them with a conceptual boundary that at least partially demarcated them from Amin’s regime. Ultimately, the case of the Uganda Prisons Service reminds us of the importance of studying prisons beyond their coercive capacities, paying attention to how such institutions became the focal point of debates over modernity, authority, and professionalism. More broadly, this study challenges the narrative of failure that has dominated popular and scholarly portrayals of state institutions on the African continent, rejecting generic depictions of the postcolony as a site of chaos and disorder.
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4

Stark, Oliver Gerhard. "Beiträge zur Precursorchemie von GaN-Materialien: Gruppe-III-Amid-Azide und Gruppe-III-Tris(trimethylstannyl)amin-Addukte." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=964937255.

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5

Vallius, Laura I. "Modulating the immune system by amino acid depletion : IDO and beyond." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:eb1a1987-4121-4042-be82-2aafb67c9941.

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Amino acid availability plays an important role in modulating the activity of T-cells. One of the pathways employed by T-cells to sense nutrient levels is the “mammalian target of rapamycin” (mTOR) pathway that is inhibited in response to nutrient depletion. Indoleamine 2,3-dioxygenase (IDO) is the first and rate-limiting enzyme along the tryptophan catabolising kynurenine pathway. T-cells are very sensitive to lack of this essential amino acid in their microenvironment and this confers strong immunomodulatory properties to cells expressing active IDO. It therefore has a significant physiological role as a homeostatic mechanism used in mammalian organisms to dampen excessive activation of the immune system but is also used as an immune evasion mechanism by many cancers. In this study, we investigated the IDO inhibitory properties and mechanism of action of the tryptophan metabolite 3-hydroxyanthranilic acid (3-HAA) that potentially forms a negative feedback loop in the kynurenine pathway. We studied the molecule in enzymatic assays, in live cells and discovered that it inhibits IDO in an indirect way via the formation of hydrogen peroxide. Secondly, we looked at the effects of tryptophan and its metabolites on T-cell proliferation and mTOR activity, and discovered a metabolite that inhibits T-cell proliferation. Lastly we examined mechanisms of T-cell suppression employed by myeloid derived suppressor cells (MDSCs), focusing on their ability to deplete amino acids from their microenvironment. We were able to exclude tryptophan consumption as a suppressive mechanism and established that by manipulating extracellular concentrations of several amino acids other than arginine and cysteine – that are known to be utilised by MDSCs - we were able to reduce their inhibitory properties. In summary, we have described in detail how 3-HAA inhibits IDO in in vitro assays, outlined how some tryptophan metabolites can inhibit T-cell proliferation, and clarified aspects of suppressive mechanism employed by MDSCs.
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6

Weiss, Felix. "Lyotrop flüssigkristalline Epoxid-Amin-Additionspolymere und Elastomere." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=970132581.

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7

Malešević, Miroslav. "[Beta]-amino [Beta-amino] acids as secondary structure inducers in peptides." [S.l. : s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=966017811.

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8

Theddu, Naresh. "APPLICATIONS OF ENANTIOPURE SULFINIMINE DERIVED CHIRAL AMINE BUILDING BLOCKS FOR THE ASYMMETRIC SYNTHESIS OF TROPANE ALKALOIDS AND CYCLIC CIS BETA-AMINO ACID DERIVATIVES." Diss., Temple University Libraries, 2011. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/157444.

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Chemistry
Ph.D.
Chiral amines are ubiquitous in natural products and are found in many drugs and drug candidates. Enantiopure sulfinimines [RS(O)N=CHR1] are useful chiral building blocks for the stereoselective synthesis of amines and amine derivatives. The aim of this thesis research is to develop new methods to access chiral amine building blocks for applications in the synthesis of nitrogen-heterocycles including ring-substituted tropinones, tropanes, cyclic cis-beta-amino acid derivatives, and amino-cyclopentitols.
Temple University--Theses
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9

Gensicke, Klaus. "Der Mufti von Jerusalem und die Nationalsozialisten : eine politische Biographie Amin el-Husseinis." Darmstadt Wiss. Buchges, 2007. http://deposit.d-nb.de/cgi-bin/dokserv?id=2945010&prov=M&dokv̲ar=1&doke̲xt=htm.

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10

Bode, Matthias. "Benzo[c][2,7]naphthyridin-5-yl-amine und Benzo[h][1,6]naphthyridin-5-yl-amine." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=979241499.

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11

Jachmann, Nicole. "Flüssigchromatographische Bestimmung aliphatischer und aromatischer Amine mit 4-Chloro-7-nitrobenzo-2-oxa1,3-diazol." [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=967326168.

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12

Kim, Jin Kyung. "Syntheses of Silanediol Amino acids and alpha-amino-alpha-alkylsilanediol precursors." Diss., Temple University Libraries, 2008. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/16809.

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Chemistry
Ph.D.
Two research projects are described: studies of the synthesis of alpha-amino-alpha-alkylsilanes, the synthetic precursor of silanediol-based protease inhibitors, and the synthesis and stability evaluation of silanediol amino acids with an unprecedently unhindered silanediol group. Two methods were investigated as approaches to alpha-amino-alpha-alkylsilanes. First, a silicon-substituted aziridine was chosen as the precursor of an alpha-amino-alpha-alkylsilane via ring opening reactions with carbon nucleophiles. Silyl-substituted aziridines 2-24 and 2-30 were prepared via direct lithiation/silylation of aziridine and employed as substrates for ring opening reactions. In spite of many attempts to ring open these silylaziridines and prepare ?-amino-?-alkylsilanes, optimization of the reaction conditions were unsuccessful. Secondly, alpha-chloro-alpha-benzylsilane 3-12 was prepared as the precursor of an alpha-amino-alpha-alkylsilane via lithiation/benzylation. The alkylation at carbon alpha to silicon to give chloromethylsilane 3-14 was successful when using n-butyllithium for lithiation, which could be explained by the steric encumbrance inherent in the structure. Several attempts for nucleophilic displacement of chloride to obtain alpha-chloro-alpha-benzylsilane 3-11 were unsuccessful possibly due to the steric effect as well as the electronic effect of silicon on the alpha carbon which made the chloride less reactive toward nucleophilic substitution. The silanediol amino acid 4-1 was synthesized originally as a potential arginase inhibitor. Although the expected biological activity was not observed, the studies on silanediol-siloxane distribution of the silanediol amino acid revealed the unique properties of this compound. Under basic conditions, the silanediol amino acid was mainly stable in monomeric form. As the pH decreased, the silanediol amino acid gave a mixture of siloxanes which consisted of a variety of stereoisomers. With available instrumental techniques, monomer, dimers and trimers of the silanediol amino acid were identified.
Temple University--Theses
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13

Baumann, Jana. "Physikalisch-chemische Untersuchungen zur Wasserstoffabgabe von BNH-Verbindungen." Doctoral thesis, [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=967597668.

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14

Lin, Guoliang. "NOVEL METHANOPYRROLIDINE β– AMINO ACIDS." Diss., Temple University Libraries, 2010. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/92631.

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Chemistry
Ph.D.
Methanopyrrolidine-5-carboxylic acids (MetPyr-5-acids), or 5-syn-carboxy-2- azabicyclo[2.1.1]hexanes are building blocks for β-peptides that cannot form backbone hydrogen bonds. To introduce functionality to this ring system, 6-syn-benzyloxymethyl and 6-syn-phenyl substituted derivatives have been prepared by an efficient synthetic procedure. Addition of appropriately substituted allyl amines to 3-butynone, amide protection, and irradiation afford mainly 5-acetyl-2-azabicyclo[2.1.1]hexanes. Haloform oxidation leads to the desired 6-substituted MetPyr-5-acids. A 1-ethoxycarbonyl-MetPyr-5-acid also was prepared in high yield. Condensation of ally amine with ethyl 2,4-dioxopentanoate afforded ethyl 2-(allylamino)-4-oxopent-2- enoate, and this was protected to give ethyl 2-[allyl(tert-butoxycarbonyl)amino]-4- oxopent-2-enoate. Irradiation afforded 5-syn-acetyl-1-ethoxycarbonyl-2- azabicyclo[2.1.1]hexane with high stereoselectivity and oxidation of the acetyl group afforded the desired 1-ethoxycarbonyl-MetPyr-5-acid. Resolutions of (±)-6-syn-benzyloxymethyl-MetPyr-5-acid and (±)-1- ethoxycarbonyl-MetPyr-5-acid were carried out (> 98% ee) by a classical resolution method using (S)-(-)-α-methylbenzylamine. The absolute configurations of (1S,4R,5R,6S)-(-)-6-benzyloxymethyl-MetPyr-5-acid and (1R,4S,5S)-(+)- 1- ethoxycarbonyl-MetPyr-5-acid were determined by X-ray analysis of their 5-(S)-(-)-α- methylbenzylamide. A prior X-ray analysis of N-Boc-(MetPyr)4-CO2Me indicated all amides to be trans oriented with all 5-syn-carbonyl groups directed toward Carbon-4 of the methanopyrrolidine. These structures were assigned as T4T4T4T4 or [T4]n (n = 4). The solution structure was not determined. Homooligomers of (1S,4R,5R)-5-syn-carboxy-2- azabicyclo[2.1.1]hexane (MPCA) terminally protected as N-Boc methylesters were constructed by EDC/HOBt coupling of terminal ester N-deprotected free amine units and N-Boc free acid units. To facilitate NMR analysis of the secondary structures of homooligomers, N-Boc was replaced by N-isobutyryl. NMR experiments indicated that N-isobutyryl-(MetPyr)n-CO2Me, (n = 2, 3, 4) have major favored [T4]n-1T where the orientation of the terminal ester carbonyl could not be determined.
Temple University--Theses
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15

Venne-Dunker, Sabine. "Bindungsaktivierung bei Bis(alkinyl)zirconocenen und Amino-funktionalisierten Zirconocenen." [S.l. : s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=967336317.

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16

Chaijamrus, Sirilux. "Enzymatic hydrolysis of renewable vegetable proteins to amino acids." [S.l. : s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=967342562.

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17

Rubini, Marina. "Protein engineering and design with non canonical amino acids." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=974166073.

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18

Voss, Rebecca. "Mesoporous organosilica materials with amine functions surface characteristics and chirality /." [S.l. : s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=975976362.

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19

Migliorini, Silene. "Metabolismo de triptofano na vigência de choque endotóxico induzido por LPS e hipertriptofanemia." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-15072011-104933/.

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Triptofano (TRP), um amino ácido essencial, é metabolizado por duas vias principais, a via das quinureninas e a via serotonérgica. Em ambas as vias há a possibilidade de formação de compostos ativos no sistema imune que se caracterizam pelas ações imunossupressoras e indutoras de tolerância. Na via serotonérgica há a formação de serotonina (5-HT) e em alguns tecidos de melatonina (MEL). Este composto pode ainda ser oxidado por ação de peroxidases aos seus produtos de abertura de anel indólico o AFMK (N1-acetil-n2-formil-5-metoxiquinuramina) e AMK (N1-acetil-5-metoxiquinuramina). Já na via das quinureninas, o TRP é diretamente metabolizado à N-formilquinurenina (NFK) e este é rapidamente deformilado a quinurenina (QUIN). Neste projeto avaliamos qual o efeito do choque endotóxico induzido por injeção endovenosa de LPS (1 mg/kg) sobre a biodisponibilidade de TRP e formação de seu metabólito QUIN. Este estudo foi realizado em condições controle e na vigência de sobrecarga de TRP (administração subcutânea de 0,8 mg/kg). Utilizamos ratos machos Wistar com 30 dias separados em quatro grupos: GI (controle), GII (LPS), GIII (TRP) e GIV (TRP+LPS). TRP (0,8 mg/Kg) foi injetado por via subcutânea nos tempos 0 e 2 horas. Quando injetado, LPS (1 mg/kg) foi administrado por via intravenosa no tempo 2 horas. Após 1 hora da última administração, sangue e cérebro foram coletados. O cérebro foi seccionado em três regiões: cerebelo, córtex e mesencéfalo, os quais foram processados para obtenção de homogenatos. Tanto os homogenatos quanto o soro foram tratados com acetona para extração de TRP e seus metabólitos. A análise destes compostos foi realizada por cromatografia líquida de alta eficiência (HPLC). A administração de TRP elevou significativamente a sua concentração no soro e no SNC. Quando da administração de LPS no grupo que já havia recebido sobrecarga de TRP (GIV) houve uma marcada elevação de TRP e de QUIN séricos e das regiões do SNC, especialmente na região do córtex. Concluímos que na vigência de choque endotóxico há um aumento da biodisponibilidade de TRP, tanto no soro como no SNC e que há um aumento da metabolização deste pela rota das quinureninas, possivelmente via IDO. Estes resultados contribuem para a compreensão da toxicidade de TRP, especialmente relevante no caso em que haja um choque endotóxico concomitante e evidencia o córtex como uma região mais susceptível para os efeitos tóxicos do TRP.
Tryptophan (TRP) is an essential amino acid, metabolized by two main paths; the kynurenine and the serotonergic pathways. In both, there is the possibility of generation of biologic active compounds, especially on the immune system leading to immunosuppression and tolerance. In the serotonergic path there is the formation of serotonine (5-HT) and in some tissues of melatonine (MEL). The latter can be oxidized by the action of peroxidases to its indole ring opening product AFMK (N1-acetil-n2-formil-5-methoxikynuramine) and AMK (N1-acethyl-5-methoxykynuramine). In the kynurenine path, TRP is metabolized to N-formylkynurenine (NFK) that is deformilated to kynurenine (KYN). In this study we evaluated the effect of a endotoxic skock induced by an intravenous injection of LPS (1 mg/kg) on the bioavailability of TRP and formation of KYN. This study was carried out in control conditions and on TRP overload (subcutaneous administration of 0,8 mg/Kg). One month old male Wistar rats were divide in four groups: GI(control), GII(LPS), GIII(TRP) and GIV (TRP+LPS). TRP (0,8 mg/kg) was subcutaneously injected at zero and 2h times. When injected, LPS (1mg/kg) was intravenously administered at 2 h. After one hour from the last administration, blood and brain were collected. Brain is separated in cerebellum, midbrain and cortex and was lysed for the preparation of homogenates. Both, serum and homogenates were extracted in acetone; TRP and KYN were analyzed by HPLC. TRP overload caused a significant increase in its concentration in serum and brain. When LPS was administered in conjunction with TRP overload (GIV) there was a remarkable increase in TRP and KYN in serum and brain, especially in cortex. Our conclusion is that in the bioavailability of TRP, in serum and in brain, and its metabolization to kynurenine is increased by inflammation. IDO is probably involved in this condition. Our results contribute to the knowledge of TRP toxicity, particularly with a concomitant inflammation and demonstrate the cortex as a region of more susceptibility to TRP toxicity.
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20

Auro, Bhima. "Amino acid residue burial & co-evolution in proteins." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4611/.

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Analysis of the amino-acid co-substitution patterns has long promised the prediction of protein structure but has failed to deliver. One possible reason is that most methods presume that co-substitution is indicative of residue-residue contact, yet the extent to which this conjecture is true is unproven. Here, a method is developed to investigate the relationship between specific co-substitution types and their propensity to occur at different physical separations in a protein structure. Amino-acids are typically segregated into two types; hydrophilic residues, predominantly found on the protein surface, and the hydrophobic residues in the protein interior. Thus, the propensity of a given amino-acid substitution occurring at the surface must differ from that in the interior of the protein, the implications of this for co-substitution has never previously been considered. To allow a definition of surface and buried residues, the cross-over point demarcating the surface residues from the protein interior was calculated here, using a Half Sphere Exposure with a radius of 13 A, as 20 HSEu, above which value a residue can be considered buried, and below which it can be considered to be on the surface.
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21

Moss, Sam. "New synthetic methods to access non-coded amino acids." Thesis, University of Huddersfield, 2014. http://eprints.hud.ac.uk/id/eprint/26443/.

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Amino acids are a ubiquitous class of compounds which are vital to the existence of all life on earth. In addition to providing the building blocks of life’s machinery, they are increasingly finding use as starting materials for total syntheses, as ligands in chiral catalysis or as novel pharmaceutically active compounds in their own right. As such, the development of new synthetic methods to access existing -amino acids, as well as previously unknown amino acids is of significant importance. The introduction contained in the first part of this report aims to provide a general overview of the catalytic methods currently used to prepare -amino acids, as well as to highlight a notable class of -amino acids called the kainoids, with specific attention directed to covering previous total synthesis routes to access (-)--kainic acid. The work described in the second part of this report was based on the extension of methodology developed by Shaw, and focuses on attempts to develop catalytic, diastereoselective aldol reaction methodology with azido hydroxamic acid-containing substrates in order to prepare diastereomerically pure -amino acids. The third and final section of this report discusses the preparation of substituted tetrahydropyridinium ylide precursors and their subsequent rearrangement in the presence of neutrally-generated benzyne is explored. The selectivity observed when asymmetric arynes are generated as reactive species was also investigated. Finally, the successful expansion of this methodology to acyclic substrates is also discussed.
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22

Reng, Diana. "AMPA-([alpha]-amino-3-hydroxy-5-methyl-4-isoxazolpropionsäure) [AMPA-(Alpha-amino-3-hydroxy-5-methyl-4-isoxazolpropionsäure)] induzierte Exzitotoxizität im Innenohr der Taube (Columba livia)." [S.l.] : [s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=960082239.

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23

Gensicke, Klaus. "Der Mufti von Jerusalem und die Nationalsozialisten eine politische Biographie Amin el-Husseinis." Darmstadt Wiss. Buchges., [Abt. Verl.], 1987. http://deposit.d-nb.de/cgi-bin/dokserv?id=2945010&prov=M&dok_var=1&dok_ext=htm.

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24

Meyer, Thomas. "Synthese, Cyclisierung und biologische Wirksamkeit von 4-Amino-5-hydroxy-chinolinen." [S.l.] : [s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=963598260.

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Bresolin, Igor Tadeu Lazzarotto. "Purificação de anticorpos monoclonais utilizando IMAC em membranas de fibra oca de PEVA : c : omparação dos agentes quelantes IDA, CM-Asp e TREN." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/266218.

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Orientador: Sonia Maria Alves Bueno
Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Quimica
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Resumo: Anticorpos monoclonais são imunoglobulinas secretadas por clones de linfócitos B, normais, tumorais ou obtidos pela tecnologia de hibridomas. Os anticorpos monoclonais têm sido utilizados nas áreas analítica e terapêutica, o que implica na necessidade de sua obtenção com pureza superior a 95%. Muitos estudos têm sido realizados visando à purificação de anticorpos monoclonais, destacando-se as técnicas de adsorção seletiva, como as cromatografias de troca iônica, hidrofóbica e de afinidade. Neste trabalho aplicou-se a cromatografia de afinidade em membranas de álcool polietileno-vinílico (PEVA), comparando o desempenho dos agentes quelantes (AQ) ácido iminodiacético (IDA), ácido aspártico carboximetilado (CM-Asp) e tris-2(aminoetil)amina (TREN) com íons metálicos imobilizados na purificação de anticorpos monoclonais anti-TNP, isotipo IgG1 a partir de sobrenadante de cultura celular precipitado e dialisado. Para determinar as melhores condições de adsorção e eluição na presença de diferentes sistemas tamponantes, foram testados os quelatos AQ-Ni2+, AQ-Zn2+ e AQ-Co2+, bem como os agentes quelantes sem metal imobilizado como grupos ionogênicos. De acordo com eletroforeses SDS-PAGE e análises ELlSA das frações dos picos de proteína obtidos, as melhores condições utilizadas para a purificação foi o uso de membranas PEVA-IDA-sem metal e PEVA-CM-Asp-Zn2+, em presença de tampão Tris-HCI 50 mM a pH 7,0 e eluição por aumento de concentração de Tris, atingindo fatores de purificação de 138,9 e 103,8 e pureza de 92,3% e 68,1%, respectivamente. A partir das isotermas de adsorção, determinou-se a capacidade máxima de adsorção e a constante de dissociação dos complexos IDA-lgG1 e CM-Asp-Zn2+ -lgG1 que, de acordo com o ajuste dos parâmetros pelo modelo de Langmuir, mostraram alta capacidade de adsorção e constantes de dissociação características de sistemas de afinidade média. Com o módulo de fibras ocas, construído em nosso laboratório, determinaram-se as curvas de ruptura por meio de experimentos de filtração para os processos propostos, e os resultados obtidos demonstraram que os sistemas de fibras ocas PEVA-IDA e PEVA-GM-Asp-Zn2+ são factíveis para a purificação de anticorpos monoclonais do isotipo IgG1
Abstract: Monoclonal antibodies are immunoglobulins produced by normal, tumoral or hybrids Iymphocytes 8 obtained by hibridoma technology. Hybridomas are resulted from the fusion of Iymphocytes B with malignant myeloma cells which express both the Iymphocyte's property of specific-antibody production and the immortal characteristic of the myeloma cells. Monoclonal antibodies have been used in analytic and therapeutic areas. This application needs highly pure antibodies. Many techniques have been studied focusing monoclonal antibodies purification. These techniques include ion exchange, hydrophobic and affinity chromatography. In this study, we applied polyethylenevinyl alcohol (PEVA) membranes in the purification of monoclonal antibody from cel! culture supematant comparing the chelating agents Iminodiacetic Acid (IDA), Carboxy-methyl Aspartic Acid (CM-Asp) and Tris-2(aminoethyl)amine) (TREN) with different immobilized metal ios, Ni2+, Zn2+ and C02+, and with different buffers. We also evaluated the adsorption and purification of monoclonal antibodies using the chelating agents as ionogenic groups. According to SDS-PAGE electrophoresis and ELlSA analysis, the higher selectivity was obtained in the presence of 50 mM Tris-HCI buffer, pH 7,0 and with elution by increasing Tris concentration, with CM-Asp-Zn2+ and IDA as ionogenic group, which provided the purification of IgG with traces of albumin, reaching purification factors of 138.9 and 103.8 and purities of 92.3% and 68.1, respectively. The adsorbent capacity and the dissociation constant of the complexes IDA-lgG1 e CM-Asp-Zn2+ -lgG1 were determinate from adsorption isotherms. According to Langmuir model, the results indicated that the matrix presents high adsorption capacity and a dissociation constant characteristic for intermediate affinity systems. We also evaluated the breaktrough curves for the proposed processes. These breaktrough curves are important to scale up procedure
Mestrado
Desenvolvimento de Processos Biotecnologicos
Mestre em Engenharia Química
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Slepukhina, Irina N. "Synthesis of boron-cluster containing amino acids and preparation of their polymers." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=980301254.

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27

Rinaldi, Sandrine. "Les hétairoi, compagnons guerriers et amis, images et réalités politiques d'Homère à Alexandre le Grand." Thesis, Paris 10, 2009. http://www.theses.fr/2009PA100196/document.

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Les hétairoi forment, dans le monde guerrier, un groupe d’hommes qui entoure un chef, avec pour principale fonction celle de le servir. Dans les poèmes homériques, l’hétairos est le guerrier qui accompagne son roi ou son chef en expédition, ou le compagnon qui reste dans l’oikos pour veiller sur les biens de celui qui est absent. En Macédoine, les hétairoi constituent, d’une part, les membres de la cavalerie macédonienne et, d’autre part, les hégèmones qui composent l’état-major. Les hétairoi sont ceux qui combattent, qui délibèrent et qui partagent le repas avec leur chef. Certains d’entre eux sont des intimes, du fait d’affinités particulières et de liens d’amitié ; ces relations personnelles s’expliquent, en général, par la notion d’âge. Ainsi, les principaux hétairoi d’un chef sont, pour la plupart, des hommes qui ont le même âge et, donc, qui ont grandi ensemble. La notion d’hétairos est attachée à un certain nombre de valeurs, comme le courage et la fidélité, et, de ce fait, cette notion se trouve liée à l’idéal héroïque. Ainsi, la force de cette communauté s’explique, certes, par le respect des valeurs, par un soutien mutuel, par des liens d’amitié, mais aussi par des pratiques sociales comme le don et le contre-don. Cependant, poussé à l’extrême, cet idéal devient hybris, démesure, et transforme les valeureux hétairoi en êtres orgueilleux, non plus soucieux de leur chef, mais de leur propre personne. Ces hétairoi deviennent, de ce fait, un danger pour le reste de la communauté ou le roi. Ce dernier n’a alors d’autre issue que celle de souhaiter, voire de tramer, leur disparition
Amongst warriors, the hetairoi are a group of men around a leader, with the main purpose of serving him. In Homeric poems, the hetairos may either be a warrior setting out with his king or chief, or a companion remaining at the oikos and taking care of his property during his absence. In Macedonia, the hetairoi are at once the men forming the Macedonian cavalry and the hegemons forming the king’s staff. The hetairoi fight alongside their leader, confer with him, and share his meals. Some are his close friends, where there are stronger affinities or personal friendship ; age usually accounts for these closer relationships. Thus many of the principal hetairoi of a chief are men of his own age group, and therefore grew up with him.The notion of hetairos refers to values such as courage and loyalty, and therefore to the heroic ideal. Thus, the strength of such a community lies in respect for these values, mutual support, and bonds of friendship but also in social practices such as gift-and-counter-gift exchanges.However, this ideal, when taken to extremes, becomes hybris, excess, and turns the valiant hetairoi into arrogant men, caring no more for their leader, but for themselves. As a result, such hetairoi come to be a danger to the rest of the community, or to the king, who is then compelled to wish for, and sometimes even to contrive their death
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Ueberlein, Susanne, Susanne Machill, Hendrik Niemann, Peter Proksch, and Eike Brunner. "The Skeletal Amino Acid Composition of the Marine Demosponge Aplysina cavernicola." Multidisciplinary Digital Publishing Institute, 2014. https://tud.qucosa.de/id/qucosa%3A28673.

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It has been discovered during the past few years that demosponges of the order Verongida such as Aplysina cavernicola exhibit chitin-based skeletons. Verongida sponges are well known to produce bioactive brominated tyrosine derivatives. We could recently demonstrate that brominated compounds do not exclusively occur in the cellular matrix but also in the skeletons of the marine sponges Aplysina cavernicola and Ianthella basta. Our measurements imply that these yet unknown compounds are strongly, possibly covalently bound to the sponge skeletons. In the present work, we determined the skeletal amino acid composition of the demosponge A. cavernicola especially with respect to the presence of halogenated amino acids. The investigations of the skeletons before and after MeOH extraction confirmed that only a small amount of the brominated skeleton-bound compounds dissolves in MeOH. The main part of the brominated compounds is strongly attached to the skeletons but can be extracted for example by using Ba(OH)2. Various halogenated tyrosine derivatives were identified by GC-MS and LC-MS in these Ba(OH)2 extracts of the skeletons.
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Meyer-Plath, Asmus Andres. "Grafting of amino and nitrogen groups on polymers by means of plasma functionalisation." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=972339787.

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Mohamed, Khaled Ahmed El-Sayed Ali. "Study to determine maximum growth capacity and amino acid requirements of Tilapia genotypes." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=96717547X.

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31

Rief, Thomas. "Neue amin- und azidsubstituierte Silane sowie Untersuchungen zur Eignung dieser Verbindungen für die Abscheidung von Silicium(IV)nitrid aus der Gasphase bei niedrigen Drücken." [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=962325465.

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32

Simonato, Jean-Pierre. "Chimie de coordination de la tétraméthylchiroporphyrine avec le fer(III), le cobalt(III) et le rhodium(III) : applications à l'analyse d'énantiomères d'amines, à la complexation énantiosélective d'aminoalcools, et à la catalyse d'aziridination asymétrique." Université Joseph Fourier (Grenoble), 1999. http://www.theses.fr/1999GRE10051.

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Des complexes metalliques de la tetramethylchiroporphyrine, de symetrie et possedant des groupements meso derives du biocartol, ont ete synthetises, caracterises, et utilises dans quatre axes de recherches. _la caracterisation du complexe bis-ethanol de la tetramethylchiroporphyrine de fer(iii), en solution et en phase solide, revele que ce compose presente un etat de spin inhabituel : le spin intermediaire pur (s = 3/2). _l'insertion d'un metal diamagnetique, le cobalt(iii), coordonnant les amines au cur de la porphyrine, a permis l'analyse qualitative et quantitative de la composition de derives d'amines par resonance magnetique nucleaire du proton. Cette methode s'est averee precise, fiable, rapide et tres facile d'utilisation. _l'addition de -aminoalcools sur cette meme molecule resulte en la complexation preferentielle d'un enantiomere. Les aspects cinetiques et thermodynamiques ont ete abordes, et une explication quant a l'enantioselectivite observee est avancee sur la base de liaisons hydrogene intramoleculaires de type c-h___o. _parmi differentes complexes de la tetramethylchiroporphyrine, ceux de fer(iii) et de manganese(iii) ont donne les meilleurs resultats pour la catalyse d'aziridination asymetrique, avec des exces enantiomeriques allant jusqu'a 57% pour le styrene. Un point remarquable est l'induction asymetrique opposee de ces deux catalyseurs, chacun favorisant la formation majoritaire d'un enantiomere.
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Koch, Kerstin. "Statistical analysis of amino acid side chain flexibility for 1:n protein protein docking." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968919413.

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Schlenstedt, Jana. "Molekulare und pharmakologische Charakterisierung von Serotonin-Rezeptoren der Honigbiene Apis mellifera." Phd thesis, [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=98002367X.

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Ahrens, Katharina Maria. "Identification of amino acid residues essential for the catalytic activity of Drosophila P element transposase." [S.l. : s.n.], 1999. http://deposit.ddb.de/cgi-bin/dokserv?idn=959520686.

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36

Rietdorf, Katja. "Wirkungen biogener Amine auf die Erregungs-Sekretions-Kopplung in der Speicheldrüse von Periplaneta americana (L.)." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=970031661.

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Foltz, Martin. "Molecular and functional characterisation of a new mammalian family of proton-coupled amino acid transporters." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=974170380.

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38

Souissi, Wided. "Cytocidal activity of Cry41Aa, an anticancer toxin from Bacillus thuringiensis." Thesis, University of Sussex, 2018. http://sro.sussex.ac.uk/id/eprint/80446/.

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Bacillus thuringiensis (Bt) is a gram positive spore forming bacterium which produces intracellular protein crystals toxic to a wide variety of insect larvae and is the most commonly used biological pesticide worldwide. More recently, Bt crystal proteins known as parasporins have been discovered, that have no known insecticidal activity but target some human cancer cells exhibiting strong cytocidal activities with different toxicity spectra and varied activity levels. Amongst these parasporins, parasporin-3 most closely resembles the commercially used insecticidal toxins and presents the narrowest activity spectrum, showing moderate cytotoxicity against only two cancer cell lines, HL-60 (Human promyelocytic leukemia cells) and HepG2 (Human liver cancer cells). Parasporin-3, also called Cry41Aa, has only been shown to exhibit cytocidal activity towards these two cell lines after being proteolytically cleaved. In order to understand this activation mechanism various mutations were made at the N- or C-terminal region of the protein and the toxicity against both HepG2 and HL-60 cell lines was evaluated. Our results indicate that only N-terminal cleavage is required for activation and that N-terminally deleted mutants show some toxicity without the need for proteolytic activation. Furthermore we have shown that the level of toxicity towards the two cell lines depends on the protease used to activate the toxin. Proteinase K-activated toxin was significantly more toxic towards HepG2 and HL-60 than trypsin-activated toxin. N-terminal sequencing of activated toxins showed that this difference in toxicity is associated with a difference of just two amino acids (serine and alanine at positions 59 and 60 respectively) which we hypothesize occlude a binding motif. Preliminary work carried out on binding showed a lack of correlation between binding and toxicity since toxin binds to both susceptible and non-susceptible cancer cell lines. In an attempt to better understand the mechanism of action of Cry41Aa against these cells, we evolved resistance in HepG2 through repeated exposure to increasing doses of the toxin. Morphological, physiological and genetic characteristics of the resistant cell line were compared with susceptible cells. Toxin was shown to bind to resistant HepG2 similarly to the susceptible line. RNA sequencing identified AQP9 as a potential mediator of resistance but extensive investigations failed to show a direct link. The involvement of certain intracellular signalling pathways were also investigated in order to understand cell responses to the toxin and showed that in response to the toxin p38, but not ERK1/2, is activated and in a dose dependent manner.
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Vadukul, Devkee M. "Factors determining the cytotoxic nature of pathogenic amyloid proteins." Thesis, University of Sussex, 2018. http://sro.sussex.ac.uk/id/eprint/79285/.

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Kyas, Andreas. "Unterschiedlich glycosidierte 2-Amino-2-desoxy-D-Glucuronsäuren Synthese und Verwendung zum Aufbau von Kohlenhydrat-Peptiden /." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=970045417.

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Thoennessen, Oliver. "Replikationsexperimente an offenen Systemen: Oligomerisierung von 5'-Amino-3'-phosphat-Oligodeoxynucleotidderivaten mit alternierenden Pyrimidin-Purin-Sequenzen." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968833683.

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42

Armitage, Georgina Kate. "The Zav'yalov pyrrole synthesis revisited : some derivatives of 3-hydroxy- and 3-amino-pyrroles." Thesis, University of Huddersfield, 2017. http://eprints.hud.ac.uk/id/eprint/34175/.

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The objective of this study was to investigate the acylative-cyclisation-decarboxylation reactions of enamino acids derived from 1,3-difunctional compounds. Remarkably little is known regarding the generality of these variants of the Zav’yalov pyrrole synthesis, despite their considerable scope for the synthesis of functionalised pyrroles. The cyclisation of diethyl 2-(1-carboxyalkylaminomethylene)malonates provided access to a range of 5-(un)substituted-4-acetoxypyrrole-3-carboxylates. However, in some instances the corresponding 4-ethoxypyrrole-3-carboxylates also accounted for up to 20% of the reaction product. 1-Acetyl-4-ethoxy-5-ethylpyrrole-3-carboxylate was characterised by X-ray crystallography. Some of the (aminomethylene)malonates from bifunctional α-amino acids provided anomalous products. For example, the glutamine-derived enamino malonate gave a 5-acetylpyrrolidin-2-one via a Dakin-West-type reaction. The asparagine-enamino malonate cyclised to 4-acetoxy-1-acetyl-5-cyanomethylpyrrole-3-carboxylate probably via an isosuccinimide intermediate. Several mechanisms for the formation of the pyrrole products have been discussed. A 13C-labelling experiment confirmed that the carboxyl function in the starting material is not incorporated in the product. Evidence for the involvement of a 1,3-oxazolium-5-olate (münchnone) accrued from cyclisation of diethyl 2-(1-carboxymethylaminomethylene)malonate with Ac2O in the presence of dimethyl acetylenedicarboxylate which provided a novel 1-alkenylpyrrole, characterised by X-ray crystallography. An alternative pathway supervenes in the Zav’yalov reaction when α,α-disubstitution of the amino acid prevents münchnone and thus pyrrole formation to afford an N-alkenyloxazolidin-5-one. Novel ethyl 4-(di)acetamido-5-(un)substituted-pyrrole-3-carboxylates and the corresponding 3-carbonitriles have been obtained in good yields via the cyclisation of ethyl 2-(1-carboxyalkylaminomethylene)cyanoacetates and (1-carboxyalkylaminomethylene)malononitriles respectively. Evidence for a different cyclisation pathway, in the former, involving intramolecular acylation of the enaminonitrile moiety was observed. Thus, ethyl (2R*,3S*)-1-acetyl-3-cyano-2,4-diacetoxy-5-methyl-2,3-dihydropyrrole-3-carboxylate was characterised by X-ray crystallography. A wide range of novel 2-alkanoyl- and 2-aroyl-3-(1-carboxyalkylamino)acrylonitriles has been obtained via aminomethylenation of β-ketonitriles. The products from their cyclisations (Ac2O-NEt3) were largely independent of the nature of the acyl group but determined by the substituent in the α-amino acid moiety. The 3-(1-carboxy-1-phenylmethylamino)acrylonitriles provided mixtures of 3-acyl-4-(di)acetamido-5-phenylpyrroles in which the 4-acetamido- derivatives predominated. Contrasting behaviour was displayed by the 3-(1-carboxyalkylamino)acrylonitriles derived from alanine, 2-aminobutyric acid and valine in which the cyclisation followed an unexpected course, via enaminone acylation, to the novel 4-acetoxy-1-acetyl-5-alkylpyrrole-3-carbonitriles in high yields. The acylative cyclisation of the 2-acyl-3-(1-carboxymethylamino)acrylonitriles furnished mixtures of pyrroles. In two cases, 3-acetamido-6-aryl-5-cyanopyran-2-ones, generated by a unique cyclisation pathway were isolated. The structure of the 6-phenyl- derivative was confirmed by unambiguous synthesis. The synthesis and acylative cyclisation of (Z)-2-benzoyl-3-(1-carboxyalkylamino)crotononitriles was investigated. Whereas the 3-(1-carboxyethylamino)- derivative provided 4-acetoxy-1-acetyl-2,5-dimethylpyrrole-3-carbonitrile exclusively, the 3-(1-carboxy-1-phenylmethylamino)crotononitrile afforded a mixture of pyrroles. A remarkable minor component was characterised as 4-acetoxy-1-benzoyl-2-methyl-5-phenylpyrrole-3-carbonitrile, the result of sequential [1,5]-benzoyl migrations of a 3H-pyrrole intermediate. The acylative cyclisation of 3-(1-carboxyalkylamino)-2-tosylacrylonitriles provides access to hitherto unknown 3-diacetamido-4-tosyl- and 3-acetamido-4-tosylpyrroles. Cyclisation of 2-(1-carboxyalkylaminomethylene)dibenzoylmethanes offers an excellent, complementary approach to access 5-(un)substituted-3-benzoyl-4-phenylpyrroles, to the existing tosylmethyl isocyanide-based protocols.
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43

Zia, Mariam. "Religious orientations, storytelling and the uncanny : a reading of The Adventures of Amir Hamza." Thesis, University of Sussex, 2017. http://sro.sussex.ac.uk/id/eprint/67330/.

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44

Kolberg, Matthias. "Generation and characterization of free and metal associated amino acid radicals in ribonucleotide reductase using EPR techniques." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=963516744.

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45

Miranda, Manoela. "Molecular and functional characterization of amino acid and peptide transporters in developing seeds of Vicia faba L." [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=964312131.

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46

Walberg, Jörg. "Ausgleich der fehlenden Inkretinstimulation der Insulinsekretion durch Exogenes GLP-1 [7-36 Amid] bei der parenteralen Ernährung." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=974372390.

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47

Alshebli, Abdulmohsen. "Towards making urban planning practices more effective amid rapid urban growth in Riyadh, Saudi Arabia." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8472/.

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This thesis explores the area of urban planning practices examining the rapid urban growth in Riyadh. The research was motivated by the fact that Riyadh continues to suffer from rapid uncontrolled urban growth, with resultant problems in its infrastructure. These problems are associated with the urban planning path failures, both in terms of the discourses and the practices. As result, the urban plan did not help to control the city growth. The research firstly analyses the driving forces that influence urban planning, focusing on three issues as the main reasons for ongoing expansion: planning law, planning structure, and how planning relates to energy discourses in Saudi Arabia. Secondly, it evaluates spatial planning practices revealing four themes for developers and planners to consider: settlement patterns, urban design, land use patterns and transport. Thirdly, by revealing the mechanisms underlying the planning environment it demonstrates how the structures in place affect urban planning practices. Finally, based on the literature review and the findings of the empirical chapters and interviews with those who work in urban planning the thesis offers an understanding of planners’ practices, how they contribute to continued unsustainable growth and, offers policy recommendations for a more sustainable planned future for Riyadh and other cities in Saudi Arabia.
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48

Kemp, Harley. "Investigating the effect of plant amino acid transporters AtAAP1 and AtAAP2 on aphid-plant interactions." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/3169/.

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A model system of Myzus persicae, Brevicoryne brassicae and Arabidopsis thaliana was used to investigate the effect of loss of function mutations in the plant amino acid transporter genes, AtAAP1 (Accession number: At1g58360) and AtAAP2 (Accession number: At5g09220). Homozygous mutant lines for each transporter were screened for phenotypic changes. Silique numbers and total silique seed mass were reduced for both aap1 and aap2 plants in comparison to wildtype plants (p < 0.05). Individual seed weight was also significantly reduced in aap2 plants (p < 0.05). Aphid probing behaviour, measured using EPG, indicated both aphid species took significantly longer attempting to locate a sieve element and reach sustained E2 feeding when on aap1 and aap2 plants (p < 0.05). The rate of aphid feeding was also significantly slower for both aphid species feeding on aap1 and aap2 (p < 0.05). M. persicae and B. brassicae feeding on aap1 and aap2 exhibited no change in aphid performance when compared to aphids on control plants (p > 0.05). Following antibiotic elimination of aphid symbionts in both species, aposymbiotic aphids were found to grow significantly slower on aap1 and aap2 plants in comparison with aposymbiotic aphids feeding on control plants (p < 0.005).
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Yu, Minghao, Zifan Wang, Haozhe Zhang, Panpan Zhang, Tao Zhang, Xihong Lu, and Xinliang Feng. "Amino Functionalization Optimizes Potential Distribution: A Facile Pathway Towards High-Energy Carbon-Based Aqueous Supercapacitors." Elsevier, 2019. https://tud.qucosa.de/id/qucosa%3A74442.

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Resolving the mismatch between the practical potential window (PPW) and the available capacitive potential window of supercapacitor electrodes provides a feasible way to expand the operating voltage of supercapacitors, which further boosts energy density. Here, our research unveils a unique approach to manually control the PPW of the corresponding carbon-based supercapacitors (CSCs) by rational functionalization with amino groups. The extra pair of electrons from amino N atoms naturally adsorbs cations in the electrolyte, which rationalizes the surface charge of the carbon electrode and adjusts the PPW. A remarkable voltage expansion is achieved for CSCs, from 1.4 V to its maximum limit, 1.8 V, correspondently resulting in an approximately 1-fold increase in the energy density. Importantly, such a simple strategy endows our CSCs with an outstanding maximum energy density of 7.7 mWh cm⁻³, which is not only among the best values reported for thin-film CSCs but also comparable to those reported for Li thin-film batteries. These encouraging results are believed to bring fundamental insights into the nature of potential control in energy storage devices.
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50

Maina, Mahmoud Bukar. "From chromatin to protein synthesis : the role of glutamate, amyloid beta and tau in Alzheimer's disease." Thesis, University of Sussex, 2017. http://sro.sussex.ac.uk/id/eprint/70463/.

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