Relevant bibliographies by topics / Amino β-lactam

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  2. Dissertations / Theses
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  4. Conference papers

Academic literature on the topic 'Amino β-lactam'

Author: Grafiati
Published: 5 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "Amino β-lactam"

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Kanwar, Seema, та Sain D. Sharma. "(Chloromethylene)Dimethylammonium Chloride: A Highly Efficient Reagent for the Synthesis of β-Lactams from β-Amino Acids". Journal of Chemical Research 2005, № 11 (2005): 705–7. http://dx.doi.org/10.3184/030823405774909414.

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(Chloromethylene)dimethylammonium chloride 1, is a unique reagent that conveniently and efficiently mediates the amide bond formation in β-lactams via cyclodehydration of β-amino acids leading to β-lactam formation. The process involves the formation of a highly reactive activated ester of a β-amino acid which gets cyclised to the corresponding β-lactam in excellent yield. The reaction proceeds smoothly and cleanly as the by-products formed are the water soluble-dimethyl formamide and triethylamine hydrochloride.
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Li, Lu, Qiyao Wang, Hui Zhang, Minjun Yang, Mazhar I. Khan та Xiaohui Zhou. "Sensor histidine kinase is a β-lactam receptor and induces resistance to β-lactam antibiotics". Proceedings of the National Academy of Sciences 113, № 6 (2016): 1648–53. http://dx.doi.org/10.1073/pnas.1520300113.

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β-Lactams disrupt bacterial cell wall synthesis, and these agents are the most widely used antibiotics. One of the principle mechanisms by which bacteria resist the action of β-lactams is by producing β-lactamases, enzymes that degrade β-lactams. In Gram-negative bacteria, production of β-lactamases is often induced in response to the antibiotic-associated damage to the cell wall. Here, we have identified a previously unidentified mechanism that governs β-lactamase production. In the Gram-negative enteric pathogenVibrio parahaemolyticus, we found a histidine kinase/response regulator pair (Vbr
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Omote, Masaaki, Atsushi Tarui, Masakazu Ueo та ін. "One-Pot Ring-Opening Peptide Synthesis Using α,α-Difluoro-β-Lactams". Synthesis 52, № 23 (2020): 3657–66. http://dx.doi.org/10.1055/s-0040-1707238.

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α,α-Difluoro-β-lactams successfully underwent ring-opening aminolysis with various amino acids in 2,2,2-trifluoroethanol to afford fluorine-containing peptides. In this aminolysis, it was found that 2,2,2-trifluoroethanol first attacked the α,α-difluoro-β-lactams with cleavage of lactam ring to form the corresponding open-chain 2,2,2-trifluoroethyl esters as reactive intermediates. The trifluoroethyl esters were more electrophilic compared with the corresponding methyl ester and thereby accelerated the aminolysis with various amino acids to form β-amino acid peptides with α,α-difluoromethylene
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Terada, Tomohiro, Hideyuki Saito, Mayumi Mukai та Ken-Ichi Inui. "Recognition of β-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells". American Journal of Physiology-Renal Physiology 273, № 5 (1997): F706—F711. http://dx.doi.org/10.1152/ajprenal.1997.273.5.f706.

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PEPT1 and PEPT2 are H+-coupled peptide transporters expressed preferentially in the intestine and kidney, respectively, which mediate uphill transport of oligopeptides and peptide-like drugs such as β-lactam antibiotics. In the present study, we have compared the recognition of β-lactam antibiotics by LLC-PK1 cells stably transfected with PEPT1 or PEPT2 cDNA. Cyclacillin (aminopenicillin) and ceftibuten (anionic cephalosporin without an α-amino group) showed potent inhibitory effects on the glycylsarcosine uptake in the PEPT1-expressing cells. Other β-lactams, such as cephalexin, cefadroxil, a
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Skoglund, Erik, Henrietta Abodakpi, Rafael Rios, et al. "In Vivo Resistance to Ceftolozane/Tazobactam in Pseudomonas aeruginosa Arising by AmpC- and Non-AmpC-Mediated Pathways." Case Reports in Infectious Diseases 2018 (December 23, 2018): 1–4. http://dx.doi.org/10.1155/2018/9095203.

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Two pairs of ceftolozane/tazobactam susceptible/resistant P. aeruginosa were isolated from 2 patients after exposure to β-lactams. The genetic basis of ceftolozane/tazobactam resistance was evaluated, and β-lactam-resistant mechanisms were assessed by phenotypic assays. Whole genome sequencing identified mutations in AmpC including the mutation (V213A) and a deletion of 7 amino acids (P210–G216) in the Ω-loop. Phenotypic assays showed that ceftolozane/tazobactam resistance in the strain with AmpCV213A variant was associated with increased β-lactamase hydrolysis activity. On the other hand, the
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LaCuran, Alecander E., Kevin M. Pegg, Eleanor M. Liu та ін. "Elucidating the Role of Residue 67 in IMP-Type Metallo-β-Lactamase Evolution". Antimicrobial Agents and Chemotherapy 59, № 12 (2015): 7299–307. http://dx.doi.org/10.1128/aac.01651-15.

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ABSTRACTAntibiotic resistance in bacteria is ever changing and adapting, as once-novel β-lactam antibiotics are losing their efficacy, primarily due to the production of β-lactamases. Metallo-β-lactamases (MBLs) efficiently inactivate a broad range of β-lactam antibiotics, including carbapenems, and are often coexpressed with other antibacterial resistance factors. The rapid dissemination of MBLs and lack of novel antibacterials pose an imminent threat to global health. In an effort to better counter these resistance-conferring β-lactamases, an investigation of their natural evolution and resu
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Wheadon, Michael J., та Craig A. Townsend. "Evolutionary and functional analysis of an NRPS condensation domain integrates β-lactam, ᴅ-amino acid, and dehydroamino acid synthesis". Proceedings of the National Academy of Sciences 118, № 17 (2021): e2026017118. http://dx.doi.org/10.1073/pnas.2026017118.

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Nonribosomal peptide synthetases (NRPSs) are large, multidomain biosynthetic enzymes involved in the assembly-line–like synthesis of numerous peptide natural products. Among these are clinically useful antibiotics including three classes of β-lactams: the penicillins/cephalosporins, the monobactams, and the monocyclic nocardicins, as well as the vancomycin family of glycopeptides and the depsipeptide daptomycin. During NRPS synthesis, peptide bond formation is catalyzed by condensation (C) domains, which couple the nascent peptide with the next programmed amino acid of the sequence. A growing
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Remete, Attila Márió, та Loránd Kiss. "Alicyclic β- and γ-Amino Acids: Useful Scaffolds for the Stereocontrolled Access to Amino Acid-Based Carbocyclic Nucleoside Analogs". Molecules 24, № 1 (2019): 161. http://dx.doi.org/10.3390/molecules24010161.

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Stereocontrolled synthesis of some amino acid-based carbocyclic nucleoside analogs containing ring C=C bond has been performed on β- and γ-lactam basis. Key steps were N-arylation of readily available β- or γ-lactam-derived amino ester isomers and amino alcohols with 5-amino-4,6-dichloropyrimidine; ring closure of the formed adduct with HC(OMe)3 and nucleophilic displacement of chlorine with various N-nucleophiles in the resulting 6-chloropurine moiety.
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Guérin, François, Christophe Isnard, Vincent Cattoir та Jean Christophe Giard. "Complex Regulation Pathways of AmpC-Mediated β-Lactam Resistance in Enterobacter cloacae Complex". Antimicrobial Agents and Chemotherapy 59, № 12 (2015): 7753–61. http://dx.doi.org/10.1128/aac.01729-15.

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ABSTRACTEnterobacter cloacaecomplex (ECC), an opportunistic pathogen causing numerous infections in hospitalized patients worldwide, is able to resist β-lactams mainly by producing the AmpC β-lactamase enzyme. AmpC expression is highly inducible in the presence of some β-lactams, but the underlying genetic regulation, which is intricately linked to peptidoglycan recycling, is still poorly understood. In this study, we constructed different mutant strains that were affected in genes encoding enzymes suspected to be involved in this pathway. As expected, the inactivation ofampC,ampR(which encode
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Wachino, Jun-ichi, Yoshihiro Yamaguchi, Shigetarou Mori, Hiromasa Kurosaki, Yoshichika Arakawa та Keigo Shibayama. "Structural Insights into the Subclass B3 Metallo-β-Lactamase SMB-1 and the Mode of Inhibition by the Common Metallo-β-Lactamase Inhibitor Mercaptoacetate". Antimicrobial Agents and Chemotherapy 57, № 1 (2012): 101–9. http://dx.doi.org/10.1128/aac.01264-12.

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ABSTRACTA novel subclass B3 metallo-β-lactamase (MBL), SMB-1, recently identified from aSerratia marcescensclinical isolate, showed a higher hydrolytic activity against a wide range of β-lactams than did the other subclass B3 MBLs, i.e., BJP-1 and FEZ-1, from environmental bacteria. To identify the mechanism underlying the differences in substrate specificity among the subclass B3 MBLs, we determined the structure of SMB-1, using 1.6-Å diffraction data. Consequently, we found that SMB-1 reserves a space in the active site to accommodate β-lactam, even with a bulky R1 side chain, due to a loss
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Dissertations / Theses on the topic "Amino β-lactam"

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Bhattacharya, Biplob. "Synthesis and Anti-MRSA Activity of Hydrophilic C3-Acylated N-Thiolated β-Lactams and N-Acyl Ciprofloxacin-N-Thiolated β-Lactam Hybrids". Scholar Commons, 2012. http://scholarcommons.usf.edu/etd/4289.

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The Turos laboratory has been working with N-thiolated β-lactams for years trying to understand the mode of action and structural features it needs to have biological activity. Over the years new data has shown promising inhibitory activity against various microbes. In this dissertation, a review of the vast amount of work carried out on N-thiolated β-lactams in Turos laboratory has been done and their novelty, in terms of structure and mechanism has been discussed. A complete outline of our work in the discovery and ongoing development of these compounds, starting from our initial, unexpected
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Flanigan, David L. Jr. "Studies in Rhodium Catalyzed Intramolecular C-H Insertion of Amino Acid Derived α-Diazo-α-(substituted)acetamides and its Application to the Total Synthesis of clasto-Lactacystin β-Lactone". Scholar Commons, 2004. https://scholarcommons.usf.edu/etd/1037.

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Lactacystin is a microbial metabolite isolated by Omura that exhibits neurotrophic activity in neuroblastoma cell lines. Lactacystin and especially its β-lactone analog are the first examples of non-polypeptide small molecules capable of specifically inhibiting the 20S proteasome. Various asymmetric total syntheses of lactacystin and its analogs have been reported. The total synthesis of clasto -lactacystin β-lactone is achieved using L-serine methyl ester as the starting material and the sole source of stereochemical induction. The success of this synthesis hinges on two featured transformati
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Rodionov, Dmitrii Gennadievitch. "Regulation of β-lactam-induced lysis in escherichia coli". Thesis, 1996. http://hdl.handle.net/1828/7369.

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The penicillin tolerance of ammo acid-deprived re/A+ Escherichia coli is attributed to the stringent response. The β-lactam-induced lysis of amino acid-deprived bacteria resulting from relaxation of the stringent response was inhibited by cerulenin, or by glycerol deprivation in the case of a gpsA mutant (defective in the biosynthetic snglycerol 3-phosphate dehydrogenase). Therefore, β-lactam-induced lysis of amino acid-deprived cells was dependent on phospholipid synthesis. Both the priming and the lysis induction stages of β-lactam-induced lysis were shown to require phospholipid synthesis
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Geranurimi, Azade. "Lactam-peptide modulators of biased interlukin-1 receptor signaling for mitigating inflammation without compromising immuno-vigilance." Thesis, 2019. http://hdl.handle.net/1866/23926.

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Les accouchements prématurés restent un défi pour la médecine moderne. Malgré les efforts de préventions déployés, les taux de naissances prématurés sont en constante augmentation dans les pays industrialisés. Le récepteur interleukine-1 (IL-1R) a été étudié dans le but de développer des agents thérapeutiques pouvant prolonger la gestation et mener à des prognostiques néonataux. Dans cette optique, il y a été démontré que le peptide 101.10 possède a démontré une capacité à moduler le récepteur IL-1R, retarder les accouchements prématurés et réduire l’incidence de la rétinopathie prématurée pa
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Schneiderová, Michaela. "Heterologní exprese genu pro esterasu alfa-aminokyselin z kmene Achromobacter sp. CCM 4824 v Escherichia coli BL21(DE3)." Master's thesis, 2015. http://www.nusl.cz/ntk/nusl-343816.

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On the chromosomal DNA of the microorganism Achromobacter sp. CCM 4824, which was gained in the Laboratory of enzyme technology MBU AVCR v.v.i., there was identified a gene coding an enzyme capable of hydrolyzation of semi-synthetic β-lactam antibiotics ampicillin and cephalosporin with a D-phenylglycine as a side chain. This enzyme belongs to a group of α-amino acid esterases, which are interesting because of a potential use in kinetically controled synthesis of β-lactam antibiotics. In several aspects α-amino acid esterases might be better than actually used penicillin acylases and that is w
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TRULLI, LAURA. "Reactivity of trifluoromethyl aldimines with active methylene compounds." Doctoral thesis, 2016. http://hdl.handle.net/11573/924571.

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In this thesis the reactivity of N-protected trifluoromethyl (E)-aldimines towards different active methylene compounds in the Mannich-type and aza-Reformatsky reactions was studied. At first, suitable trifluoromethyl aldimines were reacted with β-dicarbonyl compounds, including diethyl malonate and several β-keto esters. The presence of a trifluoromethyl group, lowering both nitrogen basicity and carbon electrophilicity of the imine C=N group, greatly affects the Mannich-type addition of β-dicarbonyl compounds. In fact, the most common organic or inorganic bases, such as some organocatalysts
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Zanobini, Alessandra [Verfasser]. "Synthesis of new spirocyclopropanated β-lactams [beta-lactams] and their application as building blocks for β-amino [beta-amino] acid peptides / vorgelegt von Alessandra Zanobini". 2005. http://d-nb.info/979970334/34.

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Book chapters on the topic "Amino β-lactam"

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Palomo, C., and M. Oiarbide. "β-Lactam Ring Opening: A Useful Entry to Amino Acids and Relevant Nitrogen-Containing Compounds." In Heterocyclic Scaffolds I. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/7081_2009_11.

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Page, Michael I. "Structure and Reactivity of β-Lactams." In Amino Acids, Peptides and Proteins in Organic Chemistry. Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527631803.ch5.

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Palomo, Claudio, Jesús M. Aizpurua, Iñaki Ganboa та Mikel Oiarbide. "Synthesis of β-Amino Acids and Their Derivatives from β-Lactams: Update". У Enantioselective Synthesis of β-Amino Acids. John Wiley & Sons, Inc., 2005. http://dx.doi.org/10.1002/0471698482.ch20.

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Barredo, José Luis, Marta Rodriguez-Sáiz, José Luis Adrio, and Arnold L. Demain. "Synthesis of β-Lactams (Cephalosporins) by Bioconversion." In Amino Acids, Peptides and Proteins in Organic Chemistry. Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527631803.ch4.

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Konaklieva, Monika I., and Balbina J. Plotkin. "Asymmetric Synthesis of β-Lactams via the Staudinger Reaction." In Amino Acids, Peptides and Proteins in Organic Chemistry. Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527631827.ch9.

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Ojima, Iwao, Larisa Kuznetsova, Ioana Maria Ungureanu, Antonela Pepe, Ilaria Zanardi, and Jin Chen. "Fluoro-β-lactams as Useful Building Blocks for the Synthesis of Fluorinated Amino Acids, Dipeptides, and Taxoids." In ACS Symposium Series. American Chemical Society, 2005. http://dx.doi.org/10.1021/bk-2005-0911.ch031.

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Wolkenberg, S. E., and R. M. Garbaccio. "[2+2] Cycloaddition and the β-Lactam Route to Amino Acids." In Three Carbon-Heteroatom Bonds: Acid Halides; Carboxylic Acids and Acid Salts. Georg Thieme Verlag KG, 2007. http://dx.doi.org/10.1055/sos-sd-020-00397.

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Yamamoto, Yoshinori, Naoki Asao, and Naofumi Tsukada. "Asymmetric synthesis of β-amino acids and β-lactam derivatives via conjugate addition of metal amides." In Advances in Asymmetric Synthesis Volume 3. Elsevier, 1999. http://dx.doi.org/10.1016/s1874-5148(98)80003-1.

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Nacsa, Eric D., and Tristan H. Lambert. "Oxidation." In Organic Synthesis. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190646165.003.0006.

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Huanfeng Jiang at the South China University of Technology developed (J. Am. Chem. Soc. 2013, 135, 5286) the palladium-catalyzed dehydrogenative aminohalogenation of methyl acrylate with aniline 1. A 1,3-hydrogen shift/ chlorination catalyzed by an iridium complex was reported (Angew. Chem. Int. Ed. 2013, 52, 6273) by Belén Martín- Matute at Stockholm University. Robert M. Waymouth discovered (J. Am. Chem. Soc. 2013, 135, 7593) the chemoselective oxidation of polyol 5 by a cationic palladium species. A ruthenium(II) hydride was found to catalyze the conversion of alcohols such as 7 to carboxyl
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Taber, Douglass F. "C–N Ring Construction: The Glorius Synthesis of ent-Monomorine." In Organic Synthesis. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190646165.003.0054.

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Ryan Gilmour of the Westfälische Wilhelms-Universität Münster employed (Chem. Eur. J. 2014, 20, 794) an organocatalyst to direct the enantioselective aziridination of 1 to 2. Vanessa Kar-Yan Lo and Chi-Ming Che of Hong Kong University devised (Angew. Chem. Int. Ed. 2014, 53, 2982) a Ru catalyst for the enantioselective aziridi­nation (not illustrated) of terminal alkenes. Shu-Li You of the Shanghai Institute of Organic Chemistry and Aiwen Lei of Wuhan University described (Angew. Chem. Int. Ed. 2014, 53, 2443) the Pd-mediated carbonylation of 3 to the β-lactam 4. Professor You reported (J. Am.
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Conference papers on the topic "Amino β-lactam"

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Yongo-Luwawa, Charity D., та William D. Lubell. "Synthesis and application of β-amino γ-lactam (Bgl) residues". У 37th European Peptide Symposium. The European Peptide Society, 2024. http://dx.doi.org/10.17952/37eps.2024.p2247.

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