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Dissertations / Theses on the topic 'Amino acid metabolism'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Poole, Philip. "Amino acid metabolism in Rhizobium." Thesis, Poole, Philip (1986) Amino acid metabolism in Rhizobium. PhD thesis, Murdoch University, 1986. https://researchrepository.murdoch.edu.au/id/eprint/51728/.

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Addition of a broad range of L-amino acids and several D-amino acids to washed cells of Rhizobium leguminosarum strains WU235 and MNF3841 grown on glucose/NH4Cl elicited a low rate of O2 consumption. L-Glutamate, L-glutamine, L-aspartate, L-asparagine, L-alanine or L-histidine served as the sole source of nitrogen and carbon for growth of strain WU235 and each caused a several-fold increase in the amino acid dependent O2 consumption. In all these cultures excess ammonia was liberated, with the quantity depending on the number of nitrogen atoms per amino acid molecule. A very high dicarboxylic

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2

Ebikeme, Charles E. "Amino acid transporters and amino acid metabolism in trypanosoma brucei brucei." Connect to e-thesis, 2007. http://theses.gla.ac.uk/55/.

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Thesis (Ph.D.) - University of Glasgow, 2007.<br>Ph.D. thesis submitted to the Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, 2007. Includes bibliographical references.

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3

Ebikeme, Charles E. "Amino acid transporters & amino acid metabolism in Trypanosoma brucei brucei." Thesis, University of Glasgow, 2007. http://theses.gla.ac.uk/55/.

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The development of new drugs against Human African Trypanosomiasis is much needed due to toxicity, efficacy and availability problems with current drug treatments for this resurgent parasitic disease. Delivery of drugs into cells is an important determinant of therapeutic efficacy of drugs. An effective means of selective drug delivery is to use plasma membrane transport systems to mediate the entry of drugs into the cell. Some amino acid transporters fulfil the criteria needed for successful exploitation of nutrient transport systems for drug delivery. The Trypanosoma brucei genomic database

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4

Cooper, Leah. "Nonessential amino acid metabolism in humans." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/52641.

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Nutritionally, there is a dietary requirement for the essential amino acids (EAA) but also a requirement for nitrogen (N) intake for the de novo synthesis of the nonessential amino acids (NEAA). It has been suggested that some NEAA may be more metabolically important than others. The first study (Glutamate Requirement Study) aims to examine the application of the indicator amino acid oxidation (IAAO) technique to determine if a dietary requirement for glutamate exists in adult humans. The second study (NEAA Study) aims to determine the metabolic demand of nine of the NEAA (Ala, Arg, Asn, Asp,

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5

Wang, Alice Chun-Yin. "Amino acid metabolism in the inflammatory niche." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/28572.

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Stroma and parenchyma represent the supportive and functional components in every organ of the body, respectively. Beyond their ability to produce structural support and to differentiate into tissues of mesodermal origin, mesenchymal stromal cells (MSC) exhibit potent immunomodulatory properties. Such a function requires an activation step ('licensing signal') provided by the inflammatory microenvironment to which MSC are exposed. My results have attributed immunosuppressive effects of MSC to essential amino acid (EAA) deprivation. Amongst the EAA consuming enzymes examined, blocking nitric ox

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6

Hou, Chunsheng 1968. "Sulfur amino acid catabolism in a piglet model." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=78381.

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A model was developed in growing piglets to study the use of urinary total sulfur excretion as an indicator of sulfur amino acid (SAA) catabolism and the nitrogen (N)/sulfur (S) balance ratio as an indicator of non-protein SAA storage. The recovery of administrated methionine as urinary total S over 48 hours was 106% in well-nourished piglets, but only 69% in protein malnourished piglets. The N/S balance ratio of protein malnourished piglets was lower than that of well-nourished piglets, and this ratio further decreased after methionine administration. We conclude that in a protein maln

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7

Sharer, Nicholas M. "Sulphur amino acid metabolism, oxidative stress and pancreatitis." Thesis, University of Southampton, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.396793.

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8

Lee, Edward Robert. "Investigations related to branched-chain amino acid metabolism." Thesis, University of Warwick, 1989. http://wrap.warwick.ac.uk/99899/.

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A novel synthetic route to heterogeneous acyloins was developed using benzothiazole/thiazolium species. The synthetic route mimics the biological action of thiamine pyrophosphate (TPP) in acetohydroxyacid synthase, the first enzyme of the valine-isoleucine biosynthetic pathway. The synthetic intermediates were examined by x- ray crystallography. Racemic [3,4-13C2]-α-acetolactate was synthesised. Treatment of the 13C-labelled α-acetolactate with acetolactate decarboxylase and analysis of the subsequent reactions by Hnmr showed that the enzyme rapidly decarboxylated the S-isomer to give [l,2-13C

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9

Brown, Toby James Neville. "Analytical studies of some amino acid secondary metabolism." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300806.

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10

Hawkey, Robin Keith. "Amino acid oxidation and protein metabolism in animals." Thesis, University of Nottingham, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334760.

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11

Salter, M. "Aromatic amino acid metabolism in the rat liver." Thesis, University of Manchester, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374780.

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12

Smith, Elizabeth Anne. "Dissimilatory amino acid metabolism by human colonic bacteria." Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627591.

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13

Mutsvangwa, Timothy. "Studies of amino acid metabolism in isolated sheep hepatocytes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq24419.pdf.

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14

Eijk, Hendrikus Maria Hubertus van. "Analytical aspects to the study of amino acid metabolism." [Maastricht : Maastricht : Universiteit Maastricht] ; University Library, Maastricht University [Host], 1999. http://arno.unimaas.nl/show.cgi?fid=6843.

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15

Dubbelhuis, Peter Foeke. "Regulation of metabolism by amino acid dependent signal transduction." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2004. http://dare.uva.nl/document/75780.

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16

Kyriakopoulos, Sarantos. "Amino acid metabolism in Chinese hamster ovary cell culture." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/25143.

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The present thesis focuses on amino acids (a.a.) and their metabolism by Chinese hamster ovary cells, the workhorse of the multibillion dollar biopharmaceutical industry. The aim of the research was to explore a.a. transport and metabolism and define optimal operating conditions during fed-batch culture, which is the most common process mode used industrially. A fast and reliable way to calculate a.a. concentration ranges in media and feeds is of vital importance, as a.a. are the monomers of proteins, which account for 70% of dry cell weight. The desired recombinant product of bioprocesses is

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17

Myers, Adelyn. "Modeling post absorptive amino acid metabolism in dairy cattle." Thesis, Virginia Tech, 2018. http://hdl.handle.net/10919/95890.

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The purpose of this research was to evaluate four objectives: 1) update and evaluate predictions of essential amino acid (EAA) outflows from the rumen, 2) predict EAA use and release by the portal drained viscera (PDV) and liver (LIV) of dairy cows, 3) predict EAA use by the mammary (MAM) and non-splanchnic, non-mammary (OTH) tissues, and 4) predict milk protein production from MAM use. To evaluate the first objective, a model was constructed using previously derived equations for ruminally undegraded (RUP), microbial (MiP) and endogenous protein (EndP) flow from the rumen and refit to literat

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18

Uo, Takuma. "Enzymological Studies of D-Amino Acid Metabolism in Eucaryotes." Kyoto University, 2001. http://hdl.handle.net/2433/150758.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第8986号<br>農博第1168号<br>新制||農||819(附属図書館)<br>学位論文||H13||N3505(農学部図書室)<br>UT51-2001-F316<br>京都大学大学院農学研究科応用生命科学専攻<br>(主査)教授江﨑信芳, 教授清水昌, 教授天地輝夫<br>学位規則第4条第1項該当

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19

Pérez, Martí Albert. "The role of FGF21 in the metabolic response to amino acid restriction." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/401895.

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Obesity and associated metabolic diseases have reached epidemic proportions, affecting not only high-income countries but also low- and middle-income ones. In this context, the search for therapeutic approaches to treat obesity is becoming a priority worldwide. In this regard, the metabolic hormone fibroblast growth factor 21 (FGF21) has been identified as a potential candidate for the treatment of obesity and metabolic syndrome. Previous work by our group described that FGF21 is highly induced in liver in response to leucine deprivation and that the transcription factor ATF4 mediates this

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20

Berlo, Carolus Leonardus Hubertus van. "Splanchnic amino acid and ammonia metabolism studies in the pig /." Maastricht : Maastricht : Rijksuniversiteit Maasticht ; University Library, Maastricht University [Host], 1988. http://arno.unimaas.nl/show.cgi?fid=5614.

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21

Lee, Meng Huee. "Studies on ketoacid-dependent dioxygenases involved in amino acid metabolism." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362049.

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22

Peiris, Indrani Dammika. "Protein and amino acid metabolism during early pregnancy in sheep." Thesis, University of Reading, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280540.

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23

McLean, Mary Anne. "Amino acid neurotransmitter metabolism : computer models and '1'3C-NMR studies." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319780.

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24

Bruce, Mark. "Amino acid metabolism during exercise and recovery in human subjects." Thesis, Loughborough University, 2001. https://dspace.lboro.ac.uk/2134/33569.

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The depletion of muscle and liver glycogen observed during prolonged submaximal exercise is associated with fatigue. Re-synthesis of glycogen stores during the recovery period after exercise is therefore essential for the recovery of endurance exercise capacity. In recent years, attention has focussed on the supplementation of protein in addition to glucose-polymer during recovery from exercise in an attempt to further increase glycogen synthesis. The aims of the first and second studies in this thesis were to investigate the effect of glucose-polymer and amino acid ingestion, and solely amino

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25

Bertolo, Robert Francis. "Amino acid metabolism in parenterally and enterally fed piglets, how important is gut metabolism?" Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0027/NQ51033.pdf.

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26

Bruce, C. I. "Metabolism of preformed amino acids by rumen bacteria in vivo." Thesis, University of Nottingham, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376397.

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27

Karlsson, Anna. "Exploring amino acid metabolism in Saccharomyces cerevisiae for improved eco-efficient production of chiral amine." Thesis, Malmö universitet, Fakulteten för hälsa och samhälle (HS), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-25085.

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Kirala aminer används idag både som aktiva substanser och som bindningsmedel i flertalet läkemedel, dock är dagens produktion med kinetic resolution ineffektiv vilket gör att mer effektiva och miljövänliga produktionssätt eftersträvas. Biotransformation har visat sig både vara miljövänligt och en effektiv metod för att producera kirala aminer. Aminosyror kan användas som aminodonatorer för att producera den kirala aminen 1-methyl-3-phenylpropylamine (MPPA) från prokirala ketonen bensylaceton (BA) med hjälp av aminetransaminas. I denna studie användes metaboliskt konstruerad Saccharomyces cerev

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28

Gowrie, Ian Joseph. "A mew method to estimate whole body protein turnover in man." Thesis, City University London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269291.

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29

Smith, Douglas W. 1961. "The lysinuric protein intolerance phenotype : amino acid transport in cultured skin fibroblasts." Thesis, McGill University, 1986. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=65416.

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30

Rathbone, Daniel Lee. "Synthetic and enzymatic studies related to branched-chain amino acid metabolism." Thesis, University of Warwick, 1987. http://wrap.warwick.ac.uk/55738/.

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Several sytheses of a-acetolactate analogues (2-hydroxy-3-oxo carboxylic esters) and related compounds were developed. The action of the enzyme acetolactate decarboxylase upon these compounds was studied. A synthesis of 3-bromo-2-oxo carboxylic acids, esters and amides was developed. Inhibition studies using methyl 3-bromo-3-methyl-2-oxo butanoate with pig liver esterase indicated that the esters were not suitable mechanism-based inhibitors of the enzyme. A synthesis of 3-hydroxy-2-oxo carboxylic esters was developed. These compounds were found to isomerise, via alkyl group migration, to the c

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31

Barona, Gómez Francisco. "Functional and structural genomics of amino acid metabolism in Streptomyces coelicolor." Thesis, University of Warwick, 2003. http://wrap.warwick.ac.uk/59424/.

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An investigation of amino acid metabolism in Streptomyces coelicolor, including the anabolism of tryptophan, histidine, the branched-chain amino acids and proline, as well as the catabolism of the latter, is reported. The experiments reported herein were conceptually conceived within a functional genomics framework. For this purpose the complete genome sequence of S. coelicolor was systematically exploited. Moreover, the current knowledge on the physiology of Streptomyces was taken onboard, as well as the prevailing and emerging notions on the evolution of proteins and metabolic pathways. Some

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32

Rushowski, Clare Elizabeth. "A study of pathogenicity and amino acid metabolism in Stagonospora nodorum." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390793.

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33

Heinemann, Björn [Verfasser]. "Amino acid metabolism under drought stress in Arabidopsis thaliana / Björn Heinemann." Hannover : Gottfried Wilhelm Leibniz Universität, 2021. http://d-nb.info/1238221696/34.

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34

Howlett, R. M. "Analysis of Campylobacter jejuni amino acid metabolism and solute transport systems." Thesis, University of Sheffield, 2013. http://etheses.whiterose.ac.uk/3792/.

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35

Ceppa, Florencia Andrea <1986&gt. "Diet: Microbiota Interaction in the Gut-Focus on Amino Acid Metabolism." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7348/1/Florencia.Ceppa_tesi.pdf.

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This study aims to measure the impact of protein and amino acid fermentation on the composition and metabolic output of gut microbiota. Although dissimilatory pathways have been described for most amino acids, microbial degradation routes within the gut microbiota are relatively unexplored. The objectives were (1) to characterize amino acid breakdown by the colonic microbiota, (2) to determine the fermentation products formed from individual amino acids/protein (3) to examine how amino acid metabolism is impacted by the presence of a fermentable fiber (prebiotic inulin) and finally (4) to eval

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36

Ceppa, Florencia Andrea <1986&gt. "Diet: Microbiota Interaction in the Gut-Focus on Amino Acid Metabolism." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7348/.

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This study aims to measure the impact of protein and amino acid fermentation on the composition and metabolic output of gut microbiota. Although dissimilatory pathways have been described for most amino acids, microbial degradation routes within the gut microbiota are relatively unexplored. The objectives were (1) to characterize amino acid breakdown by the colonic microbiota, (2) to determine the fermentation products formed from individual amino acids/protein (3) to examine how amino acid metabolism is impacted by the presence of a fermentable fiber (prebiotic inulin) and finally (4) to eval

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37

Miniaci, Sandra A. "Maternal dietary glucose restriction and its effect on amniotic fluid amino acid composition." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0001/MQ44224.pdf.

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38

Boyd, Shelton Roosevelt. "Characterization of the amino acid transporter AAP1 in Arabidopsis thaliana." Thesis, Virginia Tech, 2018. http://hdl.handle.net/10919/99368.

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Amino acids are essential molecules in plant metabolism. Amino acids carry reduced nitrogen while serving as precursors for protein synthesis and secondary metabolites. Translocation of amino acids in the cell is mediated by amino acid transporters. While about 100 transporters have been identified, only a dozen have been fully characterized. The regulation of amino acid transporters is not fully understood and stands as the basis of this study. Previous toxicity-based screenings of Arabidopsis thaliana mutants led to the isolation of a loss-of-function line and the phenylalanine insensitive g

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39

Cruz, Maria Eliane de Melo da. "The regulation of amino acid and protein metabolism in the lactating rat." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.253389.

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40

AJAZI, ARTA. "ATG6/BECLIN 1 COUPLES THE REPLICATION STRESS RESPONSE TO AMINO ACID METABOLISM." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/471447.

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In the budding yeast Saccharomices Cerevisiae, Atg6 is a non-catalytic component of the phosphatidylinositol (PtdIns) kinase complex Vps34-Vps15-Atg6, which phosphorylates PtdIns to produce phosphatidylinositol 3-phosphate (PtdIns(3)P). Atg6 is conserved among species, including its mammalian ortologue, Beclin 1, which is partially inactivated in breast and ovarian cancers. Beclin 1 involvement in human cancer is not fully established, but it could act as a tumor suppressor by regulating autophagy. Genome instability is a hallmark of cancer cells. The replication stress checkpoint has evolv

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41

Roussel, Guenièvre. "The effects of amino acid deprivation on iron metabolism in Caco-2 cells." Thesis, University of Aberdeen, 2016. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=229800.

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42

Zhang, Qingfen. "Peptide Fragmentation and Amino Acid Quantification by Mass Spectrometry." Diss., The University of Arizona, 2006. http://hdl.handle.net/10150/195288.

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Research presented in this dissertation falls into two parts: fragmentation mechanisms of peptide and fragmentation mechanism of amino acid derivatives. The study of peptide fragmentation may help to improve protein identification by incorporating the rules governing this process into search algorithms. This study elucidates the chemical 'rules' governing peptide dissociation. It is believed that these 'rules' can be incorporated into searching algorithms to achieve better protein identification. The present study focuses on the effects of different amino acids on fragmentation. Amino acids w

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43

Mueller, Martin J. "Leukotriene A₄ hydrolase : identification of amino acid residues involved in catalyses and substrate-mediated inactivation /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4934-4/.

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44

Zhang, Yongfang. "Amino acid metabolism and requirement in teleost during their early life stages and implications in fish formulated diets." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1199374737.

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45

Pollard, Matthew. "Cloning and molecular characterisation of novel sodium dependent glutamine and glutamate transport systems." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364871.

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46

Jackson, Nicola Clare. "The effect of nutritional support and GH/IGF-I treatment on glutamine metabolism in the critically ill." Thesis, King's College London (University of London), 2000. https://kclpure.kcl.ac.uk/portal/en/theses/the-effect-of-nutritional-support-and-ghigfi-treatment-on-glutamine-metabolism-in-the-critically-ill(fc28929f-a22e-4dbb-899e-cbb158298674).html.

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47

Higham, S. M. "Studies in the relationship between pH, carbohydrate and nitrogen metabolism in human dental plaque." Thesis, University of Liverpool, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382064.

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48

Kim, Ji-Hyuk. "Effect of amino acid balance on energy and nitrogen metabolism in growing broiler chickens." Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/28358.

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Three experiments were performed to test the assumption that imbalanced dietary amino acid mixtures must lead to increased heat production. The first experiment was based on diets formulated to have a wide range of crude protein concentrations but a fixed concentration of lysine, formulated to be the first-limiting amino acid. In the second experiment, lysine concentration was varied over a wide range while CP content was kept constant. To prevent the masking of dietary effects by thermoregulatory demands, the third experiment was performed at 30°C with the diets similar to the diets used in t

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49

TOMBARI, CAMILLA. "Role of mutant p53 as mechanosensitive regulator of amino-acid metabolism in breast cancer." Doctoral thesis, Università degli Studi di Trieste, 2022. http://hdl.handle.net/11368/3014980.

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Amino acids are crucial nutrients for cancer cells since they provide plenty of metabolic and energetic intermediates and promote their survival in challenging environments, thus enabling them to proliferate, disseminate and generate metastases. Tumors are indeed avid for amino acids and, consequently, they aberrantly increase amino acids intake, biosynthesis and catabolism. This metabolic reprogramming represents an Achille’s heel of tumors. Thus, unveiling the oncogenic drivers that reprogram amino acid metabolism in cancer is fundamental to understand disease progression and to find therape

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50

Harper, Peter Andrew Windsor. "Studies on neurological disorders of neonatal calves associated with spongy changes in the central nervous system : neuroaxial oedema and the inborn errors of amino acid metabolism." Thesis, The University of Sydney, 1987. https://hdl.handle.net/2123/25996.

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Investigations of neurological disease in neonatal calves were conducted over a four and a half year period. The studies commenced with so called Hereditary Neuraxial Oedema of Poll Hereford calves. It was determined that two distinct disease entities in this breed had led to confusion regarding the diagnosis of this disorder.

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