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Dissertations / Theses on the topic 'Amino acid; Neurotransmitter'

Author: Grafiati

Published: 4 June 2021

Last updated: 14 February 2022

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1

Agarwal, Shailesh Ramjilal. "Pharmacological modeling and regulation of excitatory amino acid transporters (EAATS)." CONNECT TO THIS TITLE ONLINE, 2007. http://etd.lib.umt.edu/theses/available/etd-09262007-111510/.

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2

Chao, Chih-Kai. "The vesicular glutamate transporter (VGLUT) heterologous expression, proteoliposome, computational and mass spectral studies /." CONNECT TO THIS TITLE ONLINE, 2008. http://etd.lib.umt.edu/theses/available/etd-12112008-140102/.

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3

Neville, Lewis Frederic. "Pre-synaptic modulation of cortical excitatory amino acid neurotransmitter release." Thesis, University of Southampton, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328909.

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4

McLean, Mary Anne. "Amino acid neurotransmitter metabolism : computer models and '1'3C-NMR studies." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319780.

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5

Magnuson, David Stuart Keith. "Analysis of excitatory amino acid receptors in the rat spinal cord in vivo and in vitro." Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/29017.

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Several endogenous amino acids including L-glutamate and L-aspartate have potent excitatory effects in the central nervous system. They are thought to act as synaptic transmitters in many neural pathways including those in the spinal cord. Three distinct receptors have been described through which these excitatory amino acids exert their effects. These are referred to as quisqualate, kainate and N-methyl-D-aspartate (NMDA) receptors, after the exogenous excitants most specific for each. In addition, sub-types of the NMDA receptor have been proposed to account for differences observed in the ac

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6

Glencorse, Thora Ann. "Molecular biology of the chicken brain GABAâ†A receptor." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240925.

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7

Nusser, Zoltan. "Localisation of amino acid neurotransmitter receptors in the hippocampus and cerebellum." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260787.

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8

Meredith, Rhiannon Mair. "Amino acid neurotransmitter release in the chick forebrain following filial imprinting." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621357.

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9

Teoh, Hwee. "Modulation of neurotransmitter amino acid release from the rat isolated spinal cord." Thesis, University College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321647.

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10

Smith, Wesley Edward. "Elucidation of the Specificity of Neuroactive Steroids and Related Compounds at the at the Vesicular Glutamate Transporter." The University of Montana, 2007. http://etd.lib.umt.edu/theses/available/etd-09262007-110515/.

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As the primary excitatory amino acid, glutamate is essential to proper functioning of the mammalian CNS. Proper regulation of the synaptic release of glutamate, potentially regulated by synaptic vesicle content, is one of many critical aspects to normal excitatory functioning. In particular, the vesicular glutamate transporters (VGLUTs), which load synaptic vesicles with glutamate prior to presynaptic release of neurotransmitter, are distinct from that of the plasma membrane excitatory amino acid transporters (EAAT). The development of a library of compounds which selectively inhibit the uptak

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11

Boulland, Jean-Luc. "Recycling the amino acid neurotransmitter glutamate in the CNS : l'alchimie du glutamate et de la glutamine." Paris 6, 2004. http://www.theses.fr/2004PA066017.

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12

Harrison, Lydia Margaret. "Effects of alteration of the dietary amino acid balance on brain neurotransmitter concentrations and patterns of growth and food intake in the chick." Thesis, University of Edinburgh, 1988. http://hdl.handle.net/1842/28203.

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13

Smith, Samantha Jane. "Amino acid neurotransmitter function in the prefrontal cortex : neurochemical basis for modulation via potential targets for antipsychotic drugs." Thesis, University of Sheffield, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.401170.

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14

Tripathy, Srikant. "Interactions between GABAergic, dopaminergic and cholinergic neurotransmitter systems in form deprived myopic chick." Queensland University of Technology, 2008. http://eprints.qut.edu.au/18385/.

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Myopia is a refractive defect of the eye in which collimated light produces images focused in front of the retina. Myopia can be artificially induced in animal models by form deprivation (form deprivation myopia, FDM) or by application of negative lenses (lens induced myopia, LIM). In this study myopia was induced using diffusers. The project had two main aims: 1. To determine if there is an interaction between the GABAergic system and dopaminergic system in the retina in terms of myopia? 2. To determine if there is an interaction between the GABAergic system and cholinergic system in the

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15

Mavencamp, Terri Lynn. "Design, synthesis and biological evaluation of a family of excitatory amino acid transporter 3 (EAAT3) preferring inhibitors." [Missoula, Mont.] : The University of Montana, 2008. http://etd.lib.umt.edu/theses/available/etd-03212009-152926/unrestricted/Mavencamp_umt_0136D_10009.pdf.

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16

Wafford, Keith Allan. "Receptors for amino acid neurotransmitters in the insect CNS." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.330264.

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17

Smith, Adam Luke. "Characterization of excitatory amino acid receptors using novel structural analogues." Thesis, University of Oxford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302953.

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18

Luk, Kelvin. "Novel roles of amino acid neurotransmitters in mammalian forebrain development." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84288.

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Neurotransmitters play multiple roles in the development and maturation of the central nervous system (CNS). In particular, glutamate and gamma-amino butyric acid (GABA) have been shown to influence the proliferation and survival of a variety of CNS cell types. Here, these two properties have been investigated in the developing rodent telencephalon. An in vivo model whereby specific subpopulations of neuronal progenitors are targeted according to their time of appearance was utilized in conjunction with stereological quantification techniques. Results demonstrate that while glutamate ha

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19

Richmond, Saul Alexander. "Characterization of excitatory amino acid receptors in the mammalian central nervous system." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308536.

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20

Ellison, D. W. "A study of amino acid neurotransmitters in Huntington's and Alzheimer's diseases." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598836.

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21

Richards, Dannette Shanon. "CHARACTERIZATION OF EXCITATORY AMINO ACID NEUROTRANSMITTERS AT MOTONEURON SYNAPSES CONTACTING RENSHAW CELLS." Wright State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=wright1260896604.

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22

Smith, Stephen E. "An investigation of the effects of electroconvulsive shock on mesolimbic dopamine and amino acid transmitter systems." Thesis, University of Oxford, 1995. http://ora.ox.ac.uk/objects/uuid:6dc583e0-cb02-4550-87cb-195ac4264f3e.

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23

Zinebi, Fatiha. "Mécanismes amino-acidergiques cellulaires impliqués dans l'hyperexcitabilité du système nerveux central de mammifère sous haute pression d'hélium : étude électrophysiologique in vitro des transferts synaptiques et électrotoniques dans l'Hippocampe de rat." Aix-Marseille 1, 1988. http://www.theses.fr/1988AIX11141.

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24

Daisley, Jonathan Niall. "The effects of passive avoidance learning on the release of amino acids and other putative transmitters in the forebrain of the day-old chick." Thesis, Open University, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308148.

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25

Pigeon, Dominique. "Etude des enzymes de synthèse des catécholamines et phosphorylation de la tyrosine hydroxylase de phéochromocytome de rat." Paris 6, 1986. http://www.theses.fr/1986PA066168.

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La structure et le régulation des enzymes de synthèse des catécholamines ont été étudiées dans le phéochromocytome de rat. Nous avons mis au point un protocole permettant la séparation des trois premiers enzymes de la voie de synthèse. Ceci a permis de purifier partiellement la dopamine beta -hydroxylase et de mettre en évidence son inhibiteur endogène, qui a été décrit pour la première fois. Nous avons montré qu'une activité protéine kinase était copurifiée avec la tyrosine hydroxylase, qu'elle phosphoryle. Cette activité a été caractérisé et la séquence primaire du site de phosphorylation a

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26

Wu, Jin. "In vivo monitoring of amino acid neurotransmitters in rat brain by microdialysis and capillary electrophoresis with laser-induced fluorescence detection." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0009/MQ60193.pdf.

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27

Butchbach, Matthew E. R. "Regulation of glutamate transport by GTRAP3-18 and by lipid rafts." Connect to this title online, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1054650123.

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Thesis (Ph. D.)--Ohio State University, 2003.<br>Title from first page of PDF file. Document formatted into pages; contains xviii, 160 p.; also includes graphics Includes bibliographical references (p. 132-160). Available online via OhioLINK's ETD Center

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28

Vyas, Chandni Atul. "Rapid Detection of Biogenic Amines using Capillary Electrophoresis and Gradient Elution Isotachophoresis." Diss., Temple University Libraries, 2010. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/112673.

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Chemistry<br>Ph.D.<br>The metabolism of amino acids produces important chemical signaling molecules called neurotransmitters, which are responsible for carrying out important actions within the human body. There are approximately one hundred identified neurotransmitters. Neurotransmitter study is important due to their involvement in biological, physiological, pharmacological, and pathological functions. Commonly employed methods for neurotransmitter detection are mainly based upon microdialysis. However, the methods suffer from disadvantages. Microdialysis fails to determine the absolute conc

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29

Friedrich, Anne. "Studies of the expression and characterization of various transport systems at RBE4 cells, an in vitro model of the blood-brain barrier." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2003. http://nbn-resolving.de/urn:nbn:de:swb:14-1060258657421-84155.

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The purpose of this study was the investigation of several transport systems expressed at the BBB. The identification and functional characterization of such transport systems is essential to provide a basis for strategies to regulate drug disposition into the brain. Immortalized rat brain endothelial cells (RBE4 cells) have been used in this study as an in vitro model of the BBB. The present study has shown that the RBE4 cells are a suitable model of the BBB for transporter studies. These cells do express the amino acid transport systems L and y+, which are known to be present at the BBB. The

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30

Friedrich, Anne. "Studies of the expression and characterization of various transport systems at RBE4 cells, an in vitro model of the blood-brain barrier." Doctoral thesis, Technische Universität Dresden, 2002. https://tud.qucosa.de/id/qucosa%3A23820.

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The purpose of this study was the investigation of several transport systems expressed at the BBB. The identification and functional characterization of such transport systems is essential to provide a basis for strategies to regulate drug disposition into the brain. Immortalized rat brain endothelial cells (RBE4 cells) have been used in this study as an in vitro model of the BBB. The present study has shown that the RBE4 cells are a suitable model of the BBB for transporter studies. These cells do express the amino acid transport systems L and y+, which are known to be present at the BBB. The

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31

Lambot, Laurie. "Etude fonctionnelle de la neurotransmission glutamatergique cortico-striatale et GABAergique striatale dans la physiologie normale et pathologique." Doctoral thesis, Universite Libre de Bruxelles, 2015. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209007.

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Apprendre de nouvelles séquences d'actions est l'une des fonctions cruciales du système nerveux central. Cet apprentissage est notamment assuré par les ganglions de la base ;ceux-ci jouent un rôle critique dans la sélection d'actions ou la prise de décisions en permettant l'apprentissage et la sélection des programmes moteurs les plus appropriés. Comprendre la physiologie de cette circuiterie neuronale hautement complexe et particulièrement celle du striatum - structure d'entrée des ganglions de la base - est donc d'une importance capitale dans l'amélioration de notre compréhension de ce systè

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32

Heneghan, John F. "M₁ Muscarinic Modulation of N-Type Calcium Channels: A Dissertation." eScholarship@UMMS, 2006. https://escholarship.umassmed.edu/gsbs_diss/255.

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The influx of calcium through N-type calcium channels (N-current) affects a myriad of neuronal functions. These include the triggering of synaptic release of neurotransmitter, adjustment of membrane potential and changes in gene transcription. N-channels are highly modulated proteins, so that N-current is attenuated or potentiated in response to environmental changes. In turn, the modulation of N-current has a direct effect on the downstream events, making the N-channel a focal point in neural signaling, and its modulation a mechanism for short term plasticity. The modulation of N-current by M

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33

Miksa, Michael. "N-Methyl-D-Aspartat-Antagonisten induzierten apoptotische Zelluntergänge im Gehirn junger Ratten." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2004. http://dx.doi.org/10.18452/15030.

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Der wichtigste exzitatorische Neurotransmitter Glutamat spielt eine grosse Rolle in der Gehirnentwicklung, wie neuronale Migration und Synaptogenese. Ob glutamaterge Stimulation für das Überleben entwickelnder Neuronen notwendig ist, war bislang jedoch unbekannt. Um zu untersuchen, ob eine Hemmung von Glutamatrezeptoren im unreifen Gehirn zu Neurodegeneration führt, wurden Ratten im Alter von 1 bis 31 Tagen für 24 Stunden mit dem N-Methyl-D-Aspartat-(NMDA) Glutamatrezeptorantagonisten Dizocilpin (MK801) behandelt. Die Dichte neuronaler Degeneration wurde mikroskopisch in Kupfer-Silber- und TUN

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34

Gabriel, Luke R. "Dynamic Regulation at the Neuronal Plasma Membrane: Novel Endocytic Mechanisms Control Anesthetic-Activated Potassium Channels and Amphetamine-Sensitive Dopamine Transporters: A Dissertation." eScholarship@UMMS, 2013. http://escholarship.umassmed.edu/gsbs_diss/725.

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Endocytic trafficking dynamically regulates neuronal plasma membrane protein presentation and activity, and plays a central role in excitability and plasticity. Over the course of my dissertation research I investigated endocytic mechanisms regulating two neuronal membrane proteins: the anesthetic-activated potassium leak channel, KCNK3, as well as the psychostimulant-sensitive dopamine transporter (DAT). My results indicate that KCNK3 internalizes in response to Protein Kinase C (PKC) activation, using a novel pathway that requires the phosphoserine binding protein, 14-3-3β, and demonstrates

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35

Domingues, Diego Soares. "Desenvolvimento de métodos por cromatografia líquida acoplada à espectrometria de massas em tandem para análises de fármacos (LC-MS/MS no modo column switching com capilar monolítico de sílica híbrida), aminoácidos e neurotransmissores (HILIC-MS/MS) em amostras de plasma de pacientes esquizofrênicos." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/59/59138/tde-03102015-152159/.

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A esquizofrenia é um transtorno neuropsiquiátrico crônico que afeta aproximadamente 1% da população mundial. As teorias neurobiológicas descrevem que a esquizofrenia é essencialmente causada por alterações bioquímicas e estruturais do cérebro, devido às disfunções nos sistemas glutamatérgico, dopaminérgico e serotoninérgico. Desta forma, a determinação das concentrações de aminoácidos e neurotransmissores em amostras de plasma de pacientes esquizofrênicos pode auxiliar na avaliação da eficácia da terapia. Além dos antipsicóticos, medicação de primeira linha no tratamento inicial da esquizofren

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36

Hwa, Chen Yu, and 陳毓華. "Regulation of Acetylcholine Release and Activity of Amino Acid Neurotransmitter Receptors by Intracellular and External pH Changes." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/16468955166330798506.

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博士<br>國立臺灣大學<br>藥理學研究所<br>87<br>It has been commonly assumed that both extracellular pH (pHo) and intracellular pH (pHi) in various excitable cells and tissues are well regulated by homeostatic mechanisms. Changes in pHo and pHi tend to exert profound effects on the properties of cells, because enzymes and ion channels are clearly affected by changes in pH. In the last two decades, however, several techniques for measuring pHi have evolved to study how pHi is regulated. Both intra- and extralcellular pH will be changed under physiological or pathological conditions. However, the

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37

Brennan, Michael James William. "Mechanisms Of Release And Reuptake Of Amino Acid Central Neurotransmitters." Thesis, 2015. http://hdl.handle.net/10539/16443.

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38

Musgrave, Travis. "Amino acid and biogenic amine concentrations during experimental autoimmune encephalomyelitis and the disease-modifying effects of phenelzine treatment." Master's thesis, 2011. http://hdl.handle.net/10048/1950.

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The project described in this thesis began with a broad analysis of the changes to amino acid and biogenic amine concentrations in the central nervous system (CNS) during experimental autoimmune encephalomyelitis (EAE) in mice, an animal model of Multiple Sclerosis (MS). That study identified deficits in specific neurotransmitters during EAE that I targeted pharmacologically using the antidepressant drug phenelzine. Phenelzine administration substantially influenced the concentrations of amino acids and biogenic amines in EAE mice in a manner likely to be therapeutic. In the final experiment,

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39

莊東憬. "Significance of L-aromatic amino acid decarboxylase activities on brain levels of the neurotransmitters catecholamine and 5-hydroxytryptamine." Thesis, 1988. http://ndltd.ncl.edu.tw/handle/67971810234604950133.

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40

Simão, Alcides Pinto. "Gas-Phase Conformational Characterization of Trace Amine Neurotransmitters: a rotational spectroscopy study." Doctoral thesis, 2020. http://hdl.handle.net/10316/91053.

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Tese no âmbito do Doutoramento em Química, ramo de Espectroscopia Molecular apresentada ao Departamento de Química da Faculdade de Ciências e Tecnologia da Universidade de Coimbra<br>A presente dissertação trata das preferências conformacionais de uma série de aminas residuais (octopamina, sinefrina, fenilglicinol e fenilefrina), bem como de um precursor aminoácido (ácido pipecólico) e de um aminossacarídeo (glucosamina), estudadas em condições de isolamento em fase gasosa recorrendo ao uso de uma combinação de técnicas de espectroscopia rotacional hifenada com ablação laser. Livre de qualq

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