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Relevant bibliographies by topics / Amino acids – Synthesis – Research / Dissertations / Theses

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Dissertations / Theses on the topic 'Amino acids – Synthesis – Research'

Author: Grafiati

Published: 4 June 2021

Last updated: 5 February 2022

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1

Brown, David. "The synthesis of amino acids by free radical methods." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670245.

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2

Landis, Geoffrey Carrothers. "Synthesis and biological activities of tachykinin and opioid-related compounds, synthesis of unusual amino acids, and the investigations into the smooth muscle pharmacology of tachykinins." Diss., The University of Arizona, 1989. http://hdl.handle.net/10150/184656.

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Eight cyclic analogues of Substance P were made in order to investigate the conformation of the C-terminal end of the peptide. These analogues were designed to test three literature models describing the active conformation of substance P. Although the potencies of the analogues were low (in the micromolar range), our results support Cotrait's and Hospital's model (1986). Several substance P antagonists were synthesized. These compounds did not demonstrate agonistic activity nor anatagonistic activity. The tryptophan side chain is contributing to the antagonistic activity of these analogues, a

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3

Middleton, Richard John. "Synthesis of unnatural [alpha] - amino acids." Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338866.

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4

Warden, Irene. "Synthesis of novel #beta# - amino acids." Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280010.

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5

Ichihara, Osamu. "Asymmetric synthesis of #beta#-amino acids." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259948.

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6

Fenwick, David R. "Asymmetric synthesis of #beta#-amino acids." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306983.

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7

Shim, Sung Bo. "Synthesis of some novel amino acids." Thesis, University of Oxford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293408.

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8

Spivey, Alan Christopher. "The synthesis of #gamma#-amino acids." Thesis, University of Oxford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293418.

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9

Humphries, Mark Edward. "Enantioselective synthesis of functionalised amino acids." Thesis, University of Bath, 1999. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.760731.

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10

Roselt, P. D. "Synthesis of side-chain functionalized amino acids." Adelaide Thesis (Ph.D.) -- University of Adelaide, Department of Organic Chemistry, 1993. http://hdl.handle.net/2440/21643.

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11

Mohamed, Nazim. "Synthesis of derivatized oxopiperazines from amino acids." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0016/NQ44518.pdf.

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12

Parsons, Andrew Frederick. "The synthesis of the Kainoid amino acids." Thesis, University of Oxford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293473.

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13

Hill, Steven. "The synthesis of bicyclic guanidino amino acids." Thesis, Cardiff University, 2012. http://orca.cf.ac.uk/42018/.

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Small molecules, such as oligopeptides can interact with nucleic acid targets and subsequently stimulate or supress biological functions. The purpose of this thesis was to produce nucleic acid targeting oligopeptides which contain non-natural amino acids as part of their sequence. Certain amino acids display selectivity for certain nucleobases. Arginine has a high propensity for being present at the binding interface of both protein-DNA and protein-RNA complexes. This thesis was aimed at the synthesis of two arginine analogues in which the guanidino side chain was locked in a bicyclic framewor

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14

Berthelot, Didier. "Synthesis of novel heterocyclic α-amino acids". Thesis, Open University, 2001. http://oro.open.ac.uk/19072/.

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This thesis describes the incorporation of heterocycles as part of an α-amino acid side-chain. Two methods were adopted. The first involved the alkylation of a pseudoephedrine glycinamide enolate using haloalkanes. The method was validated by making the naturally occurring amino acid phenylalanine. Subsequently naphthyl-, pyridyl-, biphenyl- and isoxazolyl- groups were successfully incorporated into the amino acid side chain. The enantiomeric excess of the product amino acids was found to be moderate (10-87%) due to poor diastereoselectivity in the key alkylation step. Moreover, the strict exp

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15

Lowe, Christopher. "The synthesis of antibiotics and amino acids." Thesis, University of Oxford, 1989. http://ora.ox.ac.uk/objects/uuid:e1648252-c0dc-42af-a11a-03df8ecb83c1.

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This thesis is divided into two parts: Part One describes synthetic approaches to the naturally occurring antibiotic Lactivicin (1) and its acylamino derivatives, involving the condensation of protected L-cycloserine with 2-oxoglutaric acid. The phenoxyacetyl-amino derivative (2) exhibited antibacterial activity. A method was developed for the selective deprotonation of the endocyclic amide of the protected cycloserine; the resulting anion was then quenched with various electrophiles. In this manner, the Lactivicin analogues (3) and (4) were prepared. Whilst (3) was biologically inactive, (4)

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16

Fraser, Joanne Louise. "The synthesis of enantiomerically pure amino acids." Thesis, University of Newcastle Upon Tyne, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295057.

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17

Berthelot, Didier. "Synthesis of novel heterocyclic #alpha#-amino acids." Thesis, Open University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367226.

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18

Whitcombe, Nicole Jane. "The synthesis of conformationally constrained amino acids." Thesis, King's College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251584.

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19

Knight, Jamie David. "Synthesis and applications of cyclic amino acids." Thesis, King's College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404320.

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20

O'Neill, Maeve. "Enzyme catalysed synthesis of B-amino acids." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.707605.

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21

Lovett, Victoria Jane. "Synthesis of amino acids using organometallic chemistry." Thesis, University of Sheffield, 2013. http://etheses.whiterose.ac.uk/5416/.

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22

Hutton, Craig Anthony. "Stereoselective functionalization of [alpha]-amino acids /." Title page, contents and abstract only, 1993. http://web4.library.adelaide.edu.au/theses/09PH/09phh9838.pdf.

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23

Zammit, Charlotte Maria. "Asymmetric synthesis of β- and γ- amino acids". Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:35138286-c217-4d28-990b-941149b5daa5.

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This thesis is concerned with the development of new synthetic routes for the asymmetric syntheses of a range of β- and γ-amino acids. Chapter 1 introduces the various biological activities displayed by cyclic β-amino acid containing compounds together with their occurrence in pharmaceutical molecules and β-peptides. Some of the most commonly used synthetic strategies for the preparation of carbocyclic β-amino acids are briefly described, with the focus on the formation and functionalisation of a five-membered carbocyclic ring. Chapter 2 describes a full investigation into a highly diastereose

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24

Teoh, Euneace Ching Mei. "Synthesis of amino acids by metal-catalysed reactions." Monash University, School of Chemistry, 2004. http://arrow.monash.edu.au/hdl/1959.1/9633.

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25

Christian, Paul William Nicholas. "Nitroalkenes in the asymmetric synthesis of amino acids." Thesis, Imperial College London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267891.

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26

Farthing, Christopher Neil. "The synthesis of optically active #alpha#-amino acids." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308737.

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27

Bunnage, Mark E. "Asymmetric synthesis of #beta#-amino-#alpha#-hydroxy acids." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335769.

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28

Campbell, Rachel Mary. "Towards the synthesis of isotopically labelled amino acids." Thesis, University of Newcastle Upon Tyne, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.577154.

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29

Dunn, Michael J. "Synthesis of optically active unsaturated #alpha#-amino acids." Thesis, University of Newcastle Upon Tyne, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357641.

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30

Chowdhry, Muhammad Irfan. "New methods for the synthesis of amino acids." Thesis, University of Exeter, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.479410.

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31

Cooper, Tracey Sara. "Synthesis of amino acids from chiral oxime ethers." Thesis, University of Exeter, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432786.

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32

Long, G. CliÌona. "Approaches to the synthesis of chlorinated amino acids." Thesis, University of Bristol, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.412349.

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33

Pickavance, Paul. "Synthesis of Oxo-Amino Acids by Fukuyama Coupling." Thesis, University of Sheffield, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487611.

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This thesis describes the development of the Fukuyama coupling reaction of amino acid derived organozinc iodides i and amino acid derived aryl thiol esters ii to access a range of orthogonally protected oxo-bis-amino acids iii. Pentafluorophenylthiol esters (eg iv) have been developed as alternative electrophiles in this reaction and give improved yields when compared with their non-fluorinated analogues. Application of this coupling process was then undertaken in the synthesis of the alanine-alanine dipeptide isostere v, and a range of azabicyc1o[X.Y.O]alkane amino acids, of which vi was succ

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34

Stewart, A. S. J. "Organometallic derivatives of amino acids and peptides." Thesis, Robert Gordon University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376684.

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35

Razzino, Pasquale. "Asymmetric [alpha]-amino acid synthesis /." Title page, contents and abstract only, 1991. http://web4.library.adelaide.edu.au/theses/09PH/09phr279.pdf.

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36

Li, Feng. "Synthesis of branched amino acids Isonorstatine, Phenylisothreonine, Lactacystin analogues, and amino polyols /." [S.l. : s.n.], 2007. http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-30447.

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37

Leung, Wai-yin David. "Synthesis and physical properties of fatty acid derivatives containing amino, amido functions and L-amino acid residues /." [Hong Kong : University of Hong Kong], 1993. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13637666.

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38

Bush, Stephen Michael. "The synthesis of chiral polymers derived from amino acids, and hydroxy acids." Thesis, Bangor University, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263285.

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39

Smethurst, Chris. "Asymmetric synthesis of cyclic amines." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298718.

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40

Yu, Heewon. "Pseudopoly(amino acids) : a study of the synthesis and characterization of polyesters made from α-L-amino acids". Thesis, Massachusetts Institute of Technology, 1988. http://hdl.handle.net/1721.1/16498.

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41

Zhang, Fan. "Synthesis of organometallic foldamers and cyclopropene alpha-amino acids." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 211 p, 2006. http://proquest.umi.com/pqdweb?did=1172109511&sid=6&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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42

Davis, Danny Thomas. "The stereoselective synthesis of amino acids for biosynthetic studies." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq24771.pdf.

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43

Parkes, Alastair L. "Diketopiperazines in the asymmetric synthesis of #alpha#-amino acids." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270239.

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44

Walters, Iain A. S. "The asymmetric synthesis of #alpha#-alkyl-#beta#-amino acids." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335837.

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45

Sweet, Miles J. "Applications of ÃŸ-amino acids in synthesis and structure." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418131.

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46

Jones, Catrin A. "The asymmetric synthesis of #alpha#-amino acids from imines." Thesis, Bangor University, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263167.

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47

Birchall, Andrew Carl. "The synthesis of novel homochiral polymers from amino acids." Thesis, Bangor University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310924.

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48

Fanning, Katherine Nora. "New approaches for the synthesis of unusual amino acids." Thesis, University of Glasgow, 2008. http://theses.gla.ac.uk/210/.

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The thermal and metal-catalysed aza-Claisen rearrangement of allylic trichlororacetimidates has found widespread application in the synthesis of nitrogen-containing molecules including alkaloids, antibiotics and unnatural amino acids. We have recently investigated the use of this reaction for the rearrangement of chiral molecules. This has led to the development of a highly diastereoselective, ether-directed palladium(II)-catalysed process which has been used for the synthesis of β-hydroxy-α-amino acids. To expand the scope and understanding of the rearrangement, a number of analogues of 1 hav

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49

Ochocinska, Agata. "Synthesis towards 3-ribosyl amino acids, small gene probes." Thesis, University of Reading, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.529972.

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50

Ward, Paul A. "Novel glycosyl amino acids for solid phase glycopeptide synthesis." Thesis, University of Nottingham, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413221.

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