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Dissertations / Theses on the topic 'Amino derivative'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

KRSTIC, MILENA. "IN BATCH AND IN FLOW SYNTHESIS OF QUATERNARY AMINO ACIDS/AMINO DERIVATIVES." Doctoral thesis, Università degli Studi di Milano, 2022. https://hdl.handle.net/2434/938246.

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2

Hatanaka, Takahiro. "Studies of transport of neutral/basic amino acids and amino acid-derivative drugs using intestinal brush border membrane vesicles and the ATB[0,+] clone." Kyoto University, 2002. http://hdl.handle.net/2433/149524.

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3

Uwaha, Makio. "Simple Models for Chirality Conversion of Crystals and Molecules by Grinding." The Physical Society of Japan, 2008. http://hdl.handle.net/2237/13865.

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4

Nguyen, Thach-Mien Duong. "Synthesis and decomposition kinetics of ester derivative of procarcinogen and promutagen, PhIP, 1-methyl-6-phenylimidazo[4,5-b]pyridine." Oxford, Ohio : Miami University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=miami1169670407.

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5

NGUYEN, DUONG THACH-MIEN. "SYNTHESIS AND DECOMPOSITION KINETICS of ESTER DERIVATIVE of PROCARCINOGEN and PROMUTAGEN, PhIP, 1-methyl-6-phenylimidazo[4,5-b]pyridine." Miami University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=miami1169670407.

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6

Mota, Clélia de Alencar Xavier. "Efeito antinociceptivo e antiinflamatório do 2-[(4-nitro-benzilideno)-amino]-4,5,6,7-tetraidro-benzo[b]tiofeno-3-carbonitrila (6CN10) em camundongos." Universidade Federal da Paraíba, 2012. http://tede.biblioteca.ufpb.br:8080/handle/tede/6775.

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Made available in DSpace on 2015-05-14T12:59:49Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 2233780 bytes, checksum: 36fd18af67f2bd8e2c76af844131f20c (MD5) Previous issue date: 2012-08-27<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Heterocyclic compounds are the biggest sources of synthetic drugs and have grown exponentially with important applications in the pharmaceutical industry. Amongst the heterocyclic compounds, it has been highlighted the thiophenes category and its derivatives, which call attention for presenting important pharmacological actions, especially

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7

Martins, Aline Carvalho [UNESP]. "Estudo de resistência anti-helmíntica ao monepantel em propriedades de ovinos de uma microrregião em torno de Jaboticabal-SP." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/134368.

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Submitted by ALINE CARVALHO MARTINS null (alinecarvalhomartins@hotmail.com) on 2016-02-29T01:32:05Z No. of bitstreams: 1 Tese defesa com correções.pdf: 2266757 bytes, checksum: a86bbd4a6396a41dc83d25dac4029acf (MD5)<br>Approved for entry into archive by Ana Paula Grisoto (grisotoana@reitoria.unesp.br) on 2016-02-29T16:45:46Z (GMT) No. of bitstreams: 1 martins_ac_dr_jabo.pdf: 2266757 bytes, checksum: a86bbd4a6396a41dc83d25dac4029acf (MD5)<br>Made available in DSpace on 2016-02-29T16:45:46Z (GMT). No. of bitstreams: 1 martins_ac_dr_jabo.pdf: 2266757 bytes, checksum: a86bbd4a6396a41dc83d25da

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8

Leung, Wai-yin David. "Synthesis and physical properties of fatty acid derivatives containing amino, amido functions and L-amino acid residues /." [Hong Kong : University of Hong Kong], 1993. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13637666.

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9

Peters, Steven Carlton. "Crosslinked amino acid derivatives." Title page, table of contents and abstract only, 1991. http://web4.library.adelaide.edu.au/theses/09PH/09php4831.pdf.

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10

梁偉賢 and Wai-yin David Leung. "Synthesis and physical properties of fatty acid derivatives containingamino, amido functions and L-amino acid residues." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1993. http://hub.hku.hk/bib/B31233752.

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11

Tan, Eng Wui. "Regioselective modification of amino acid derivatives /." Title page, contents and abstract only, 1990. http://web4.library.adelaide.edu.au/theses/09PH/09pht1612.pdf.

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12

Van, Kralingen Leon. "Controlled polymerization of amino acid derivatives." Thesis, Link to the Internet, 2008. https://etd.sun.ac.za/jspui/handle/10019/919.

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13

Kociuba, Katherine. "Radical functionalisation of amino acid derivatives /." Title page, table of contents and abstract only, 1996. http://web4.library.adelaide.edu.au/theses/09PH/09phk76.pdf.

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14

Hindle, Neil. "Amino sugars and their glycosides." Thesis, University of Oxford, 1995. http://ora.ox.ac.uk/objects/uuid:78ab400f-4a4c-47bb-9d18-1b3bef205044.

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This thesis describes approaches to the transformation of simple carbohydrates into a polyhydroxylated pyrrolidine and the formation of its glucosides. Chapter one describes the synthesis of the naturally occurring pyrrolidine 2,5-dideoxy-2,5-imino-D-mannitol. Synthesised from di-O-isopropylidene-D-glucose, the key steps are the introduction of nitrogen at C-5 with retention of configuration. Then cyclisation of the nitrogen onto the C-2 position with inversion to form the pyrrolidine ring. Reduction of the aldehyde furnished the polyhydroxylated heterocycle in 3.4% yield over 16 steps. The sy

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15

Goubet, D. C. M. "Asymmetric synthesis of α-amino acid derivatives". Thesis, Swansea University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.637081.

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A general background to α-amino acids is discussed in the first chapter. After a brief account on classification, properties and applications of these compounds, asymmetric processes leading to optically enriched residues are reviewed in detail. The second chapter describes the envisaged stereoselective approach towards these substrates involving Michael-type addition onto a chiral didehydroalanine derivative. Syntheses of α,β-unsaturated amino acids are reviewed after a brief section on Michael-type reactions. The preparation of a chiral didehydroamino acid residue has been investigated using

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16

Hay, M. P. "Atom transfer reactions of amino acid derivatives." Thesis, University of Canterbury. Chemistry, 1987. http://hdl.handle.net/10092/7974.

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Investigations of atom transfer reactions of amino acid derivatives are described in this thesis. Reaction of N-benzoylvaline methyl ester (29a) with sulphuryl chloride gave the β-chlorovaline derivative (30a) and lesser amounts of diastereoisomers of the r-chlorovaline derivative (31a). Studies of reactions of the valine derivatives (29a-c) with sulphuryl chloride, and of the photolyses of the corresponding N-chlorovaline derivatives (39a-c) have shown that the reaction of (29a) with sulphuryl chloride and the photolysis of (39a) involve regioselective intermolecular transfer of the respectiv

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17

Stewart, A. S. J. "Organometallic derivatives of amino acids and peptides." Thesis, Robert Gordon University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376684.

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18

Masesane, Ishmael Baperi. "Stereoselective routes to cyclic β-amino acid derivatives". Thesis, Durham University, 2003. http://etheses.dur.ac.uk/3700/.

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The literature structure of the natural product oryzoxymycin and an array of 3-mono-,3,4-di- and 3,4,5-tri-hydroxylated derivatives of 2-aminocyclohexane-l-carboxyhc acid (ACHC) were stereoselectively prepared from oxanorbomene adducts derived from the Diels Alder reaction of ethyl (E)-3-nitroacrylate and furan. The central reaction for these syntheses was the base mediated β-elimination of the oxygen bridge of the oxanorbomene adducts or their derivatives. The asymmetnc synthesis of the literature structure of oryzoxymycin involved chiral HPLC or enzyme catalysed kinetic resolution of the end

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19

Smith, David John. "Complexation of amino-acid derivatives using macrocyclic receptors." Thesis, University of Bath, 1996. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319219.

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20

Mohamed, Nazim. "Synthesis of derivatized oxopiperazines from amino acids." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0016/NQ44518.pdf.

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21

Mahajan, Anju. "Chemistry of 4-azalysine and its derivatives." Thesis, University of Nottingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324756.

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22

Laughton, Peter. "Synthesis of #beta#-carboxyaspartic acid derivatives and studies on 3-methoxycarbonylmethylene-3,4,5,6-tetrahydro- 2H-1,4-oxazine-2-one derivatives." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390088.

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23

Ng, S. C. "Enzymatic and non enzymatic synthesis of amino acid derivatives." Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379948.

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24

Kausar, Nighat. "Experimental spectroscopic and theoretical studies of amino acid derivatives." Thesis, University of Greenwich, 2008. http://gala.gre.ac.uk/6207/.

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Experimental vibrational/electronic circular dichroism spectroscopic and theoretical studies of amino acid derivatives, i.e. N-acetyl-L-Asp, N-acetyl-L-Glu, and di-amino acid peptide/derivatives, i.e. L-Asp-L-Glu, a-N-acetyl-L-Asp-L-Glu, and ß-N-acetyl-L-Asp-L-Glu are reported. The calculated structures for N-acetyl-L-Asp and N-acetyl-L-Glu differ. The conformation of the trans amide moiety changes with the carbon chain length of the side chain of the amino acid derivatives. In the computed structures of N-acetyl-L-Asp and N-acetyl-L-Glu all backbone atoms are in-plane, except the side chain g

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25

Shepherd, Emma J. "The development of enantioselective receptors for amino acid derivatives." Thesis, University of Southampton, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343011.

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26

Rossi, Sara. "Enantioselective receptors for racemate separation of amino acids' derivatives." Thesis, University of Southampton, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289912.

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27

Nieland, Nick. "Investigations of derivatives of 14#beta#-amino-7,8-dihydromorphinone." Thesis, University of Bristol, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265328.

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28

Mas-Roselló, Josep. "C-arylation and alkenylation of α-amino acid derivatives". Thesis, University of Bristol, 2017. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.738542.

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29

Clark, Howard C. S. "Amido derivatives of titanium and yttrium." Thesis, University of Sussex, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309437.

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30

Spray, Caroline Ann. "4-ketoproline derivatives as chiral templates in synthesis." Thesis, University of Sussex, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239542.

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(2S)-trans-4-Hydroxyproline has been studied as a chiral template for the preparation of kainoids. Conversion to protected 4-ketoproline derivatives has allowed functionalisation at C-3 to be investigated. Although the tendency to epimerisation has caused problems, we have successfully introduced a variety of alkyl side chains with cis stereochemistry at this position. Functionalisation of the 3-alkyl-4-ketoprolines at C-4 has been investigated and a method has been found to prepare compounds which are functionalised stereospecifically at both C-3 and C-4. These have potential for study as kai

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31

Larsson, Andreas. "Antiadhesive agents targeting uropathogenic Escherichia coli : Multivariate studies of protein-protein and protein-carbohydrate interactions." Doctoral thesis, Umeå : Dept. of Chemistry, Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-314.

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32

Wang, Yulan. "Spectroscopic studies of solid amino acid derivatives and their mixtures." Thesis, University of East Anglia, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389201.

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33

Evans, Lyndsay Ann. "Synthesis of hydroxy and amino acid derivatives using stereoselective epoxidation." Thesis, University of Sheffield, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425618.

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34

Garrido, Neil. "The asymmetric synthesis of Î±- and Î²-amino acid derivatives." Thesis, University of Reading, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.428296.

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35

Withell, Kirsti. "Gas-phase pyrolysis of amino- and amidomethylidene Meldrum's acid derivatives." Thesis, University of Edinburgh, 1998. http://hdl.handle.net/1842/11597.

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A range of new amino- and amidomethylidene Meldrum's acid derivatives have been prepared and subjected to flash vacuum pyrolysis. The <I>N-</I>substituents were chosen as potential groups for the expected pyrolysis products, pyrrol-3(2<I>H</I>)-ones. The initial use of silanes, hydrazines and benzylamines was not successful; silylamines were quantitatively deprotected on reaction with 5-methoxymethylidene Meldrum's acid (MMMA), hydrazine derivatives were successfully prepared but pyrolyses failed to produce protected pyrrolones and, although <I>N-</I>benzyl protected pyrrolones could be prepar

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36

Yamanaka, Hayato. "BIOCHEMICAL STUDIES ON SILICON-CONTAINING AMINO ACIDS AND THEIR DERIVATIVES." Kyoto University, 1999. http://hdl.handle.net/2433/181795.

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37

Theddu, Naresh. "APPLICATIONS OF ENANTIOPURE SULFINIMINE DERIVED CHIRAL AMINE BUILDING BLOCKS FOR THE ASYMMETRIC SYNTHESIS OF TROPANE ALKALOIDS AND CYCLIC CIS BETA-AMINO ACID DERIVATIVES." Diss., Temple University Libraries, 2011. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/157444.

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Chemistry<br>Ph.D.<br>Chiral amines are ubiquitous in natural products and are found in many drugs and drug candidates. Enantiopure sulfinimines [RS(O)N=CHR1] are useful chiral building blocks for the stereoselective synthesis of amines and amine derivatives. The aim of this thesis research is to develop new methods to access chiral amine building blocks for applications in the synthesis of nitrogen-heterocycles including ring-substituted tropinones, tropanes, cyclic cis-beta-amino acid derivatives, and amino-cyclopentitols.<br>Temple University--Theses

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38

Kapur, Neha. "Radical approaches towards the synthesis of peptidomimetic templates." Thesis, University of York, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323502.

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39

Glink, Peter Thomas. "Synthesis of unsaturated [alpha]-amino acid derivatives by palladium catalysed modification /." Title page, contents and absract only, 1993. http://web4.library.adelaide.edu.au/theses/09PH/09phg561.pdf.

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40

Foley, Mark Kneale. "Characterisation of the interactions between amino acid derivatives and phenolic compounds." Thesis, Bangor University, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.443633.

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41

Brown, Stuart Andrew. "Dynamic kinetic resolution : synthesis of optically active α-amino acid derivatives". Thesis, University of Edinburgh, 1999. http://hdl.handle.net/1842/13058.

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The dynamic kinetic resolution of 2-phenyl-4-subsittuted-5(4<I>H</I>)-oxazolones 89a-g has been investigated as a method for the synthesis of optically active α-amino acid derivatives. The effects of lipase, [either Novozyme (<I>Candida antarctica </I>lipase B), or Lipozyme (<I>Rhizomucor miehei</I> lipase)], solvent, nucleophile, and the addition of external triethylamine to the reaction is described. When R<SUP>1</SUP> = Ph, an 88% yield and 98% enantiomeric excess (e.e.) of α-amino acid ester 96a was obtained with Novozyme<SUP>®</SUP> in acetonitrile as solvent. The synthesis of novel 5(4<I

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42

Treweeke, Nigel R. "Preparation of #alpha#-substituted amino acid derivatives by dynamic kinetic resolution." Thesis, University of Sussex, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390818.

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43

Yatchang, Marina Fosso. "Synthesis and Biological Activity of Aminoglycosides and 1,4-Naphthoquinone Derivatives." DigitalCommons@USU, 2012. https://digitalcommons.usu.edu/etd/1371.

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The research described in this dissertation is at the interface of organic chemistry and biology, and it aimed at designing and synthesizing biologically active molecules for the possible development of therapeutic agents. Spinal muscular atrophy is an incurable disease that affects 1 in every 6000 babies, making it the leading genetic cause of infant mortality. While no treatment is available, efforts are being taken to solve this issue. Part of the work outlined in this dissertation was carried out in collaboration with researchers from the University of Missouri to investigate a potential t

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44

Vogt, Henning. "Organo catalytic strategies towards [alpha], [alpha] [alpha, alpha] disubstituted amino acid derivatives." Berlin Logos-Verl, 2006. http://deposit.d-nb.de/cgi-bin/dokserv?id=2861590&prov=M&dok_var=1&dok_ext=htm.

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45

Vukelić, Stella [Verfasser]. "Synthesis of Fluorinated Amino Acids and Their Derivatives in Flow / Stella Vukelić." Berlin : Freie Universität Berlin, 2017. http://d-nb.info/1137867884/34.

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46

Pim, Huat Phua. "Asymmetric aza-Michael reactions for the synthesis of Î²-amino acid derivatives." Thesis, Imperial College London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441296.

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47

Gaspari, Paul. "Asymmetric Synthesis of 1,3-Amino Alcohols and Tropinone Derivatives From Enantiopure Sulfinimines." Diss., Temple University Libraries, 2011. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/125180.

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Chemistry<br>Ph.D.<br>Heterocycles that contain nitrogen, such as piperidine, pyrrolidine and tropane, are widespread as natural product alkaloids and serve as templates for many bioactive drugs and drug candidates. The intent of this research is to the develop asymmetric syntheses of piperidine-containing syn and anti 1,3-amino alcohols as well as tropinone and tropane-containing derivatives using sulfinimines (N-sulfinyl imines) as precursors for acid-catalyzed cascade cyclizations. Chiral N-sulfinyl b-amino ketones derived from N-sulfinyl b-amino Weinreb amides, serve as novel and direct pr

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48

Jiang, Rong. "Benzotriazole auxiliary in the synthesis of heterocyclic compounds and amino acid derivatives." [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0011594.

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49

Atkinson, Rachel Clare. "Asymmetric α-arylation of α-amino acids via rearrangement of urea derivatives". Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/asymmetric-alphaarylation-of-alphaamino-acids-via-rearrangement-of-urea-derivatives(0a24a74d-ad3e-4db8-9b56-a0dea53be889).html.

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Quaternary amino acids are biologically important and useful building blocks for both natural product and pharmaceutical targets. They can be made from their naturally occurring proteinogenic tertiary counterparts through methods such as alkylation. However, α-arylation of amino acids is challenging with only a small number of methods available, which are far from general and access only a limited substrate scope. The N to C rearrangement chemistry established in the Clayden group allowed us to develop a transition metal-free arylation of amino acid enolates. This works by intramolecular deliv

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50

Kinney, William D. "Expansion of the Genetic Code to Include Acylated Lysine Derivatives and Photocaged Histidine." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5903.

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The genetic code of all known organisms is comprised of the 20 proteinogenic amino acids that serve as building blocks on a peptide chain to form a vast array of proteins. Proteins are responsible for virtually every biological process in all organisms; however, the 20 amino acids contain a limited number of functional groups that often leaves much to be desired. The lack of diversity addresses the need to increase the genetic repertoire of living cells to include a variety of amino acids with novel structural, chemical, and physical properties not found in the common 20 amino acids. In order

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