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Journal articles on the topic 'Amino-oxy compounds'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Laddi, U. V., and S. R. Desai. "SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW 1,3,4- OXADIAZOLES, 1,2,4-TRIAZOLES AND 1,3,4-THIADIAZOLES." INDIAN DRUGS 53, no. 06 (2016): 18–23. http://dx.doi.org/10.53879/id.53.06.10489.

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Some new 5-[(((α-phenyl/methyl)benzylidene)amino)oxy]methyl/ethyl-2-[4-(substituted aryl)/allyl)] amino-1,3,4-oxadiazoles (4a-p), 3-[(((α-phenyl/methyl)- benzylidene) amino)oxy]methyl/ethyl-4-(4- substitutedaryl)/allyl-5-mercapto-1,2,4-triazoles (5a-p) and 5-[(((α-phenyl/methyl)-benzylidene)amino) oxy]- methyl/ethyl-2-[4-(substituted aryl)/allyl)]amino-1,3,4-thiadiazoles (6a-p) were prepared starting from α/β-[((α-(phenyl/methyl)benzylidene)amino)oxy acetic/propionic acid hydrazides (1a-d). The structures of all the compounds have been established by elemental and spectral (IR, 1HNMR and mass)

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2

Laddi, U. V., and S. Desai. "SOME NEW 1,3,4-OXADIAZOLES AS ANTIMICROBIAL AGENTS." INDIAN DRUGS 53, no. 02 (2016): 15–18. http://dx.doi.org/10.53879/id.53.02.10490.

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Some new 5-[(((α-phenyl/methyl)benzylidene)amino)oxy]methyl/ethyl-2-amino/4-substituted aryl/ aryloxymethylarmercapto/piperidino/ morpholino-1,3,4-oxadiazoles (2a-d–5a-d) with biologically active biostere methyelne amino oxy methyl/ethyl moiety, were prepared starting from α/β-[((α-(phenyl/methyl) benzylidene)amino)oxy acetic/propionic acid hydrazides (1a-d). The structures of the compounds have been characterised by elemental and spectral (IR, 1HNMR and mass) analysis. All the newly synthesised compounds have been screened for their antimicrobial activity by cup plate method, against Escheric

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3

Tahira, Banu, Rajora Sonal, Khatri Dilip, and L. Talesara G. "Synthesis of some isoindole-1,3-dione and amino-oxyalkyl derivatives of benzimidazole." Journal of Indian Chemical Society Vol. 77, Jun 2000 (2000): 300–301. https://doi.org/10.5281/zenodo.5869883.

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Department of Chemistry, College of Science, Sukhadia University, Udaipur-313 001, India <em>Manuscript received 3 May 1999, revised 14 October 1999, accepted 23 February 2000</em> 2-(Bromoalkoxy)-1<em>H</em>-isoindole-1,3-diones are condensed with benzimidazole and its derivatives to give 2-[(benzimidazole-1-yl)-alkoxy]- 1<em>H</em>-isoindole-1,3-diones. Hydrolysis under acidic conditions gives the corresponding amino-oxy compounds.

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4

Mahdi, Omar, Hanaa Salih, and Abdullah Kshash. "Design, Synthesis of a Novel Banana-Shaped Compounds via Esterification." Diyala Journal For Pure Science 17, no. 4 (2021): 81–92. http://dx.doi.org/10.24237/djps.17.04.568c.

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Schiff's Bases were synthesized from the reaction of p-amino benzoic acid and alkoxybenzaldehyde in absolute ethanol and reacted with (E)-3-((4-hydroxybenzylidene) amino) phenol used DCC (N,N'-Dicyclocarbodiimide) and DAMP (4-(Dimethylamino) pyridine ) to 3-(((E)-4-((4-(((E)-4 alkoxy benzylidene) amino) benzoyl) oxy) benzylidene) amino) phenyl4- (E)- 4-alkoxy benzyli dene ) amino) benzoate. The structures of the products were confirmed by their melting points, FT-IR, 1HNMR spectra.

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5

Makarasen, Arthit, Mayuso Kuno, Suwicha Patnin, et al. "Molecular Docking Studies and Synthesis of Amino-oxy-diarylquinoline Derivatives as Potent Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors." Drug Research 69, no. 12 (2019): 671–82. http://dx.doi.org/10.1055/a-0968-1150.

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AbstractIn this study, amino-oxy-diarylquinolines were designed using structure-guided molecular hybridization strategy and fusing of the pharmacophore templates of nevirapine (NVP), efavirenz (EFV), etravirine (ETV, TMC125) and rilpivirine (RPV, TMC278). The anti-HIV-1 reverse transcriptase (RT) activity was evaluated using standard ELISA method, and the cytotoxic activity was performed using MTT and XTT assays. The primary bioassay results indicated that 2-amino-4-oxy-diarylquinolines possess moderate inhibitory properties against HIV-1 RT. Molecular docking results showed that 2-amino-4-oxy

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6

Egorova, Irina, Elena Maltseva, and Lyudmila Pinchuk. "Phytochemical study of Glycyrrhiza pallidiflora Maxim." BIO Web of Conferences 128 (2024): 00023. http://dx.doi.org/10.1051/bioconf/202412800023.

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This article presents the results of the primary phytochemical study of Glycyrrhiza pallidiflora Maxim. introduced in the southeast of Western Siberia. The qualitative and quantitative composition of several primary and secondary metabolites in underground and aboveground organs of the plant were studied in different years of introduction and vegetation period. The presence of triterpene saponins, coumarins, chromones, chalcones, aurones, 5-oxy-flavones, 5-oxy-flavonols, flavan-3-ols, and proanthocyanidins was determined. The total content of phenolic compounds in the grass reached 2.83±0.22%

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7

Khalefa, Omar S. "New Schiff base compounds with benzene moiety: FT-IR, 1H and 13C NMR Spectroscopy (1D) studies." BASRA JOURNAL OF SCIENCE 38, no. 1 (2020): 98–110. http://dx.doi.org/10.29072/basjs.20200105.

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New Schiff bases compounds containing benzene moiety has been synthesized from reaction between (4-(((4-(Alkyloxy) benzylidene) amino) methyl) phenyl)methan amine and 4-((6-bromohexyl) oxy)benzaldehyde or 4-(4-bromobutoxy)benzaldehyde. FT-IR of these compounds have been studied. The complete 1H and 13C NMR assignment of these compounds has been obtained using one-dimensional NMR techniques including 1H and 13C experiments. The data deduced from this study show that the alkyl chain and the phenyl rings are in different planes compared to the benzene ring.

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8

Khalefa, Omar S. "New Schiff base compounds with benzene moiety: FT-IR, 1H and 13C NMR Spectroscopy (1D) studies." BASRA JOURNAL OF SCIENCE 38, no. 1 (2020): 98–110. http://dx.doi.org/10.29072/basjs.20200108.

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New Schiff bases compounds containing benzene moiety has been synthesized from reaction between (4-(((4-(Alkyloxy) benzylidene) amino) methyl) phenyl)methan amine and 4-((6-bromohexyl) oxy)benzaldehyde or 4-(4-bromobutoxy)benzaldehyde. FT-IR of these compounds have been studied. The complete 1H and 13C NMR assignment of these compounds has been obtained using one-dimensional NMR techniques including 1H and 13C experiments. The data deduced from this study show that the alkyl chain and the phenyl rings are in different planes compared to the benzene ring.

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9

Vijay, Kumar Salvi, Pemawat Gangotri, Bapna Archita, and L. Talesara G. "Synthesis, characterization and antimicrobial activity of substituted 3-(phthalazine-1-ylamino)alkanoic acid containing imidoxy moiety." Journal of Indian Chemical Society Vol. 86, May 2009 (2009): 491–97. https://doi.org/10.5281/zenodo.5810168.

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Synthetic Organic Chemistry Research Laboratory, Department of Chemistry, M. L. Sukhadia University, Udaipur-313 001, Rajasthan, India <em>E-mail</em> : gtalesara@yahoo.com <em>Manuscript received 12 May 2008, revised 16 January 2009, accepted 20 January 2009</em> Hydrozinolysis of phthalyl derivatives of amino acid la-c afforded [(4-oxo-3,4-dihydrophthalazine-1- yl)amino]substituted acetic acid 2a-c, which on reaction with POCI<sub>3</sub>/PCI<sub>5</sub> gave ((4-chlorophahalazine-1-yl)amino]substituted acetic acid 3a-c. This when condensed with <em>N</em>-hydroxyphthalimide/ N-hydroxysuccin

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10

Sun, Guanghui, Weilian Xie, Hong Xiao, and Guohai Xu. "Controlled interpenetration of 44networks: syntheses and structures of two Cu3-cluster coordination polymers." Acta Crystallographica Section C Structural Chemistry 74, no. 11 (2018): 1540–46. http://dx.doi.org/10.1107/s2053229618014262.

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The reaction of copper nitrate and triethanolamine with benzene-1,4-dicarboxylic acid (bdcH2) or 4,4′-[1,4-phenylenebis(oxy)]dibenzoic acid (podaH2) leads to the formation of poly[bis(μ4-benzene-1,4-dicarboxylato-κ4O1:O1′:O4:O4)bis{μ2-[bis(2-hydroxyethyl)amino]ethanolato-κ4N,O,O′,O′′:κO}tricopper(II)], [Cu3(C8H4O4)2(C6H14NO3)2] or [Cu3(μ4-bdc)2(teaH2)2] (I), and poly[bis{μ4-4,4′-[1,4-phenylenebis(oxy)]dibenzoato-κ4O:O′:O′′:O′′}bis{μ2-[bis(2-hydroxyethyl)amino]ethanolato-κ4N,O,O′,O′′:κO}tricopper(II)], [Cu3(C20H12O6)2(C6H14NO3)2] or [Cu3(μ4-poda)2(teaH2)2], (II). The two representative compound

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11

Nováková, Zdena, Jana Tomanová, Lucie Štěrbová, and Pavel Drašar. "Steroid and bile acids amide conjugates with D-glucosamine." Collection of Czechoslovak Chemical Communications 76, no. 1 (2011): 65–74. http://dx.doi.org/10.1135/cccc2010105.

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New type of amide conjugates of steroid and bile acids with D-glucosamine 1 and 2 were prepared. Title compounds are prepared via acid chloride or using N-[({[(1E)-1-cyano-2-ethoxy-2-oxoethylidene]amino}oxy)(dimethylamino)methylidene]-N-methylmethanaminium tetrafluoroborate as condensation agent. They were examined for gelation properties with negative results. Per-O-acetylated D-glucosamine hydrochloride was prepared in one step procedure from D-glucosamine hydrochloride by acetylation in a mixture of acetyl chloride and acetic acid.

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12

Zeng, Yao-Fu, Yu-Qin Duan, Lanqing Liao, Xiaokang Long, Cheng Gao, and Xianghao Wen. "Synthesis and cytotoxic activity of 7,4’-O-modified genistein amino acid derivatives." Journal of Chemical Research 43, no. 11-12 (2019): 451–56. http://dx.doi.org/10.1177/1747519819871032.

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Fifteen 7,4’- O-modified genistein amino acid derivatives are synthesized through nucleophilic substitution and hydrolysis, followed by condensation with diverse amino acid esters. The antiproliferative activity of all the synthesized compounds is evaluated against three cancer cell lines (MGC-803, HeLa, HCT-116) and one normal cell line (HUVEC) using 5-fluorouracil (5-Fu) as the positive control. The results show that methyl [2-({5-hydroxy-3-[4-(2-{[3-(4-hydroxyphenyl)-1-methoxy-1-oxopropan-2-yl]amino}-2-oxoethoxy)phenyl]-4-oxo-4 H-chromen-7-yl}oxy)acetyl] tyrosinate exhibits significant anti

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13

Khramtsova, Ekaterina E., Ekaterina A. Lystsova, Evgeniya V. Khokhlova, Maksim V. Dmitriev, and Andrey N. Maslivets. "Amination of 5-Spiro-Substituted 3-Hydroxy-1,5-dihydro-2H-pyrrol-2-ones." Molecules 26, no. 23 (2021): 7179. http://dx.doi.org/10.3390/molecules26237179.

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The 3-hydroxy-1,5-dihydro-2H-pyrrol-2-one motif is a valuable scaffold in drug discovery. The replacement of the 3-oxy fragment in 3-hydroxy-1,5-dihydro-2H-pyrrol-2-ones-based compounds with a 3-amino one (3-amino analogs of 3-hydroxy-1,5-dihydro-2H-pyrrol-2-ones, 3-amino-1,5-dihydro-2H-pyrrol-2-ones) can play a crucial role in their biological effect. Thus, approaches to 3-amino-1,5-dihydro-2H-pyrrol-2-ones are of significant interest. We developed an approach to 5-spiro-substituted 3-amino-1,5-dihydro-2H-pyrrol-2-ones that could not be obtained using previously reported approaches (reactions

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14

Dang, Phu H., Tho H. Le, Truong N. V. Do, Hai X. Nguyen, Mai T. T. Nguyen, and Nhan T. Nguyen. "Diarylalkanoids as Potent Tyrosinase Inhibitors from the Stems of Semecarpus caudata." Evidence-Based Complementary and Alternative Medicine 2021 (January 4, 2021): 1–8. http://dx.doi.org/10.1155/2021/8872920.

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From a CHCl3-soluble extract of the stems of Semecarpus caudata (Anacardiaceae), two new diarylalkanoids, semedienone (1) and semetrienone (2), were isolated. Their structures were elucidated based on NMR spectroscopic data interpretation. These compounds possess strong tyrosinase inhibitory activity with the IC50 values of 0.033 and 0.11 μM, respectively. Docking studies of 1 and 2 with oxy-tyrosinase were carried out to analyze their interactions. Accordingly, semedienone (1) showed good interactions with the peroxide group and amino acid residues. The biosynthesis of the isolated diarylalka

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15

Wan, Li, Yang Zihui, Hu Aixi, et al. "Synthesis and fungicidal activities of 2-{[(2-(1H-1,2,4-triazol-1-yl)-ethylidene)amino]oxy}alkanamides containing dihydrobenzofuran." Heterocyclic Communications 24, no. 6 (2018): 339–44. http://dx.doi.org/10.1515/hc-2017-0245.

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Abstract In order to find new compounds with high fungicidal activity, acetamide derivatives 4a–x were rationally designed, synthesized, characterized and tested against various fungi in vivo. The bioassay results indicate that compounds 4k,m,o,r exhibit an 80% inhibition rate against Rhizoctonia solani at 500 mg/L, and compound 4j shows an 80% inhibition rate against Blumeria graminis at 500 mg/L. Therefore, compounds of 4 are promising fungicidal candidates worthy of further development.

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16

Lelyukh, Maryan I., Ivan O. Krukovskiy, Zoryana M. Komarenska, Nataliia V. Yelahina, Taras I. Chaban, and Ihor G. Chaban. "Appliance Features of 4-Amino-1,2,4-triazole-3-thiols in the Synthesis of 3,6-Disubstituted [1,2,4]Triazolo[3,4-b] [1,3,4]thiadiazoles." Acta Chimica Slovenica 72, no. 2 (2025): 238–59. https://doi.org/10.17344/acsi.2025.9169.

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4-Amino-5-substituted-4H-1,2,4-triazole-3-thiols are versatile synthons for the construction of various biologically active heterocycles. This is provided by the close proximity of the amino and mercapto groups, which serve as readily accessible nucleophilic centers for the preparation of N-bridged heterosystems. One of the possible and convenient directions of using 4-amino-4H-1,2,4-triazole-3-thiols in heterocyclic synthesis is based on their utilization in reaction with various carboxylic acids in the presence of dehydrating reagents, most often phosphorus oxychloride. Synthesized as follow

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17

Cheng, Jie, Jianwei Shao, Yifei Ye, et al. "Microfluidic Preconcentration Chip with Self-Assembled Chemical Modified Surface for Trace Carbonyl Compounds Detection." Sensors 18, no. 12 (2018): 4402. http://dx.doi.org/10.3390/s18124402.

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Carbonyl compounds in water sources are typical characteristic pollutants, which are important indicators in the health risk assessment of water quality. Commonly used analytical chemistry methods face issues such as complex operations, low sensitivity, and long analysis times. Here, we report a silicon microfluidic device based on click chemical surface modification that was engineered to achieve rapid, convenient and efficient capture of trace level carbonyl compounds in liquid solvent. The micro pillar arrays of the chip and microfluidic channels were designed under the basis of finite elem

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18

Pospíšilová, Šárka, Ivan Malík, Kristyna Bezouskova, et al. "Dibasic Derivatives of Phenylcarbamic Acid as Prospective Antibacterial Agents Interacting with Cytoplasmic Membrane." Antibiotics 9, no. 2 (2020): 64. http://dx.doi.org/10.3390/antibiotics9020064.

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1-[2-[({[2-/3-(Alkoxy)phenyl]amino}carbonyl)oxy]-3-(dipropylammonio)propyl]pyrrolidinium/azepan- ium oxalates or dichlorides (alkoxy = butoxy to heptyloxy) were recently described as very promising antimycobacterial agents. These compounds were tested in vitro against Staphylococcus aureus ATCC 29213, Enterococcus faecalis ATCC 29212 (reference and control strains), three methicillin-resistant isolates of S. aureus, and three isolates of vancomycin-resistant E. faecalis. 1-[3-(Dipropylammonio)-2-({[3-(pentyloxy-/hexyloxy-/heptyloxy)phenyl]carbamoyl}oxy)propyl]pyrrolidinium dichlorides showed h

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19

Dollendorf, Christian, Susanne Katharina Kreth, Soo Whan Choi, and Helmut Ritter. "Polymerization of novel methacrylated anthraquinone dyes." Beilstein Journal of Organic Chemistry 9 (February 28, 2013): 453–59. http://dx.doi.org/10.3762/bjoc.9.48.

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A new series of polymerizable methacrylated anthraquinone dyes has been synthesized by nucleophilic aromatic substitution reactions and subsequent methacrylation. Thereby, green 5,8-bis(4-(2-methacryloxyethyl)phenylamino)-1,4-dihydroxyanthraquinone (2), blue 1,4-bis(4-((2-methacryloxyethyl)oxy)phenylamino)anthraquinone (6) and red 1-((2-methacryloxy-1,1-dimethylethyl)amino)anthraquinone (12), as well as 1-((1,3-dimethacryloxy-2-methylpropan-2-yl)amino)anthraquinone (15) were obtained. By mixing of these brilliant dyes in different ratios and concentrations, a broad color spectrum can be genera

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20

Abeer, Fauzi Al-Rubaye, Jawad Kadhim Mohanad, and Hadi Hameed Imad. "Phytochemical Profiles of Methanolic Seeds Extract of Cuminum cyminum using GC-MS Technique." International Journal of Current Pharmaceutical Review and Research 8, no. 2 (2017): 114–24. https://doi.org/10.5281/zenodo.12677798.

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The aims of this study were identify the chemical components as well as anti-microbial activities of the methanolic seedsextract of Cuminum cyminum. GC-MS analysis revealed the existence of the Benzene , 1,1'-oxybis[4-phenoxy- ,Stearyltrimethylammonium chloride , Benzenemethanol , 4-hydroxy-α-[1-methylamino)ethyl]-,(R*,S*)- , Quinolin2(1H)-one , 3,4,5,6,7,8-hexahydro-3-dimethylaminomethyl- , 5-Hepten-2-amine , N,6-dimethyl- , 2-Pentanone , 4-amino-4-methyl- , Benzedrex , α-Pinene , 10-(dimethylaminomethyl)- , Ethanamine ,2-(2,6-dimethylphenoxy)-N-methyl-, Ephedrine , 1-(1,4-cyclohe

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21

Kovrizhina, Anastasia R., Alina A. Kolpakova, Andrei A. Kuznetzov, and Andrei I. Khlebnikov. "Ethyl 5-Oxo-5-(((12-oxoindolo[2,1-b]quinazolin-6(12H)-ylidene)amino)oxy)pentanoate." Molbank 2022, no. 4 (2022): M1451. http://dx.doi.org/10.3390/m1451.

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Indolo[2,1-b]quinazolin-6,12-dione (tryptanthrin) derivatives present important types of nitrogen-containing heterocyclic compounds which are useful intermediate products in organic synthesis and have potential pharmaceutical applications. The new ethyl 5-oxo-5-(((12-oxoindolo[2,1-b]quinazolin-6(12H)-ylidene)amino)oxy)pentanoate (Compound 2) was synthesized. Compound 2 is the first example of a tryptanthrin derivative containing a dicarboxylic acid residue in the side chain. The Z,E-isomerism of Compound 2 was investigated by DFT calculations. Bioavailability was evaluated in silico using ADME

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22

Bleshinskaya, A. S., O. G. Boldyreva, B. M. Zolotarev, V. A. Dorokhov, O. S. Chizhov, and B. M. Mikhailov. "Organoboron compounds and mass spectrometric study of derivatives of 2-amino- and 2-oxy-1,2-azaboroline." Bulletin of the Academy of Sciences of the USSR Division of Chemical Science 38, no. 3 (1989): 517–22. http://dx.doi.org/10.1007/bf00958043.

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23

Tran Hoai Tu, Nguyen Trung Nhan, and Dang Hoang Phu. "Synthesis of benzamide derivatives and evaluation of their in vitro and in silico tyrosinase inhibitory activities." Vietnam Journal of Science and Technology 62, no. 4 (2024): 660–69. http://dx.doi.org/10.15625/2525-2518/18302.

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In this research, six benzamide derivatives were traditionally synthesized using hydrazine, carbazide, and hydroxylamine derivatives through the pre- or in situ activation of the carboxylic acid functionality. Their chemical structures were identified as N′-phenylbenzohydrazide, N′-(2,4-dinitrophenyl)benzohydrazide, N′-(benzoyloxy)benzamide, N-dibenzoylurea, 2-amino-5-(4-phenyl)-1,3,4-thiadiazole, and benzohydrazide based on the interpretation of NMR spectroscopic data. Among these products, N′-phenylbenzohydrazide and N-(benzoyloxy)benzamide showed potent tyrosinase inhibitory activity with t

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24

Lauro, Figueroa-Valverde, Rosas-Nexticapa Marcela, Mateu-Armand Virginia та ін. "Preparation of two Cyclobutadiene-steroid derivatives Theoretical Analysis of its Interaction with the μ, d, and k Opiod-receptors". Oriental Journal of Chemistry 34, № 6 (2018): 2689–702. http://dx.doi.org/10.13005/ojc/340601.

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The objective of this investigation was to develop two cyclobutadiene-steroid derivatives (compounds 6 or 7) to evaluate its theoretical interaction on µ, d, and k opioid-receptors. The synthesis of 6 or 7 was carried out using a series of reactions which involves. 1) addition/cyclization: 2) imination, 3) etherification and 4) oxy-functionalization. Chemical structure of all compounds was confirmed using elemental analysis and NMR spectra. In addition, a theoretical analysis on the interaction of compounds 6 or 7 with µ, d, and k opioid-receptors was evaluated using a docking model. The resul

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Malík, Ivan, Jozef Csöllei, Ivan Solovič, et al. "Dibasic Derivatives of Phenylcarbamic Acid Against Mycobacterial Strains: Old Drugs and New Tricks?" Molecules 23, no. 10 (2018): 2493. http://dx.doi.org/10.3390/molecules23102493.

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In order to provide a more detailed view on the structure–antimycobacterial activity relationship (SAR) of phenylcarbamic acid derivatives containing two centers of protonation, 1-[2-[({[2-/3-(alkoxy)phenyl]amino}carbonyl)oxy]-3-(dipropylammonio)propyl]pyrrolidinium oxalates (1a–d)/dichlorides (1e–h) as well as 1-[2-[({[2-/3-(alkoxy)phenyl]amino}carbonyl)oxy]-3-(di-propylammonio)propyl]azepanium oxalates (1i–l)/dichlorides (1m–p; alkoxy = butoxy to heptyloxy) were physicochemically characterized by estimation of their surface tension (γ; Traube’s stalagmometric method), electronic features (lo

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Uma, P., J. Suresh, Revathi Selvaraj, and A. Arun. "Antimicrobial and Drug Releasing Studies of Novel Acrylate Polymer based on Triazine." Asian Journal of Chemistry 33, no. 11 (2021): 2707–14. http://dx.doi.org/10.14233/ajchem.2021.23018.

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This work is focused on the synthesis and characterization of versatile acrylate polymer of chalcone based triazine for their antibacterial activity and cumulative drug release behaviour studies. The novel acrylate monomer 4-(3-(4-((4-(4-(3-(4-((7-chloroquinolin-4-yl)amino)-phenyl)-3-oxoprop-1-en-1- yl)phenoxy)-6-((4-nitrophenyl)amino)-1,3,5-triazin-2-yl)oxy)phenyl)-3-oxoprop-1-en-1- yl)phenylacrylate (SCP) is from novel chalcone and acryloyl chloride. Homo and copolymers of SCP were prepared using acrylic acid and hydroxyethyl acrylate. Physical characterization confirms the formation of the

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27

Nikalje, Anna P. G., Mangesh S. Ghodke, Firoz A. K. Khan, and Jaiprakash N. Sangshetti. "Microwave Assisted Facile Synthesis and Biological Evaluation of Novel 2-Indolyl -1, 5-Benzothiazepines." Open Pharmaceutical Sciences Journal 3, no. 1 (2016): 117–30. http://dx.doi.org/10.2174/1874844901603010117.

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Background: The research work reports facile, eco-friendly microwave- assisted solvent free synthesis of coupled heterocyclic system 2-(1H-indol-3-yl)-4-substitued-2, 3-dihydrobenzo [1, 5] thiazepine derivatives obtained by cyclo condensation of 1-substituted-3(1H-indolyl)-2-propen-1-ones with 2-amino thiophenol in presence of eco-friendly catalyst zirconium(IV) oxy chloride, in solvent-free conditions. The reaction was completed in 3-6 minutes and gives better yields than the conventional synthesis which requires 6-8 hrs. Result and Conclusion: The newly synthesized compounds were evaluated f

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Chehardoli, Gholamabbas, Fatemeh Karimi, Tahmineh Akbarzadeh, Roshanak Hariri, and Zahra Najafi. "Novel 2-Amino-pyrano[3,2-c]quinoline-3-carbonitrile Derivatives Bearing Benzyloxy Phenyl Moiety as Butyrylcholinesterase Inhibitors: Design, Synthesis, In Vitro Evaluation, and Molecular Docking Studies." Avicenna Journal of Pharmaceutical Research 3, no. 2 (2022): 82–90. http://dx.doi.org/10.34172/ajpr.1068.

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Background: Alzheimer’s disease (AD), the main form of dementia, is a multifactorial neurodegenerative disease, and several hypotheses have been proposed for its pathogenesis. Among them, cholinergic hypofunction is the main reason and plays a significant role in cognitive impairment. According to this theory, ChE inhibitors improve the performance of the cholinergic system and increase memory function. Thus, this study investigated a novel series of 2-amino-pyrano[3,2-c]quinoline-3-carbonitrile derivatives bearing benzyloxy phenyl moiety as ChE enzyme inhibitors. Methods: The synthesized comp

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Sati, Bhawana, Alka Tyagi, and Anurag. "Newer Coumarin-linked Heterocyclic Hybrids: Design, Synthesis and Biological Assessment as Possible Anti-Alzheimer Drugs." Asian Journal of Chemistry 37, no. 3 (2025): 552–60. https://doi.org/10.14233/ajchem.2025.33211.

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As newer acetyl cholinesterase antagonists which could be effective in Alzheimer’s disease management, derivatives of 4-hydroxycoumarin were prepared. The 2-((2-oxo-2H-chromen-4-yl)oxy)-N-(pyridin-3-yl)acetamide derivative (4c) and 2-((2-oxo-2H-chromen-4-yl)oxy)-N-(pyridin-4-yl)acetamide (4d) showed the maximum AChE inhibition effect (IC50 = 0.957 ± 0.014 and 1.377 ± 0.018 mM, respectively) among the 16 coumarin-derived compounds evaluated against human acetylcholinesterase (hAChE). PHE 338 and HID 447 are responsible for ligand identification and trafficking by creating a polar π-π interactio

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Abu Khalaf, Reema, Areej NasrAllah, and Ghadeer AlBadawi. "Cholesteryl Ester Transfer Protein Inhibitory Activity of New 4-Bromophenethyl Benzamides." Jordan Journal of Pharmaceutical Sciences 16, no. 2 (2023): 381–90. http://dx.doi.org/10.35516/jjps.v16i2.1465.

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Cardiovascular diseases, as coronary heart disease, heart failure, and hypertension are the first leading cause of death in the United States and the third globally. CETP is a glycoprotein excreted mainly from the liver and found in plasma. Normal plasma CETP concentration is 1-4 µg/ml, while the ratio increased 70-80% in dyslipidemic patients. There is a growing need for new CETP inhibitors which encourages us to conduct this research. In this work, synthesis and in vitro study for four new 4-bromophenethylbenzamides 9a-d were carried out. In vitro study showed that the targeted compounds 9a-

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Hafez, Hend N., and Abdel-Rhman B. A. El-Gazzar. "Synthesis and evaluation of antitumor activity of new 4-substituted thieno[3,2-d]pyrimidine and thienotriazolopyrimidine derivatives." Acta Pharmaceutica 67, no. 4 (2017): 527–42. http://dx.doi.org/10.1515/acph-2017-0039.

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Abstract 3-Methyl-6-phenyl-2-thioxo-2,3-dihydrothieno[3,2-d]pyrimidin- 4(1H)-one (2), on treatment with phosphorous oxychoride, affored 4-chloro-3-methyl-6-phenyl -thieno[3,2-d]pyrimidine- 2(3H)-thione (3). A series of novel 6-phenyl-thieno[3,2-d]pyrimidine derivatives 4-9 bearing different functional groups were synthesized via treatment of compound 3 with different reagents. On the other hand, compound 2 was used to synthesize ethyl-[(3-methyl-6-phenyl-2-thioxo-2,3-dihydrothieno[ 3,2-d]pyrimidin-4-yl)-oxy]acetate (10), 2-hydrazinyl- -3-methyl-6-phenyl-thieno[3,2-d]pyrimidin-4(3H)-one (11), 3

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32

Afagnigni, Alian Désiré, Maximilienne Ascension Nyegue, Steve Valdi Djova, and François-Xavier Etoa. "LC-MS Analysis, 15-Lipoxygenase Inhibition, Cytotoxicity, and Genotoxicity of Dissotis multiflora (Sm) Triana (Melastomataceae) and Paullinia pinnata Linn (Sapindaceae)." Journal of Tropical Medicine 2020 (February 18, 2020): 1–8. http://dx.doi.org/10.1155/2020/5169847.

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This study aims to evaluate the anti-inflammatory, cytotoxicity, and genotoxicity activities of Dissotis multiflora (Sm) Triana and Paullinia pinnata Linn used traditionally in Cameroon to treat infectious diseases. Phytochemical screening was carried out using the LC-MS procedure. The ferrous oxidation-xylenol orange (FOX) assay was used to determine the 15-lipoxygenase (15-LOX) inhibitory activity of the plant samples. The tetrazolium-based colorimetric (MTT) assay was performed using Vero cells. The Ames test was carried out using Salmonella typhimurium TA98 and TA100 tester strains. LC-MS

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33

Kramar, Ana, Matea Korica, and Mirjana Kostić. "Comparative Analysis of Electrokinetic Properties of Periodate- and TEMPO-Oxidized Regenerated Cellulose Fabric Functionalized with Chitosan." Textiles 4, no. 1 (2024): 57–69. http://dx.doi.org/10.3390/textiles4010005.

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The electrokinetic properties of materials give useful insight into the behavior of surfaces in contact with liquids and other compounds and their quantification is a powerful tool to predict their behavior during further processing and application, especially in textile materials. In this work, we perform a comparative analysis of influence of the two most common selective oxidative protocols for viscose (regenerated cellulose) fabrics on subsequent functionalization with chitosan, and cellulose fabrics’ electrokinetic properties, zeta potential in a pH range of approx. 3–10, and isoelectric

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34

Garaev, Timur M., Ilya I. Yudin, Natalya V. Breslav, et al. "In Vitro Study of Antiviral Properties of Compounds Based on 1,4-Dioxane Derivative of Closo-Decaborate Anion with Amino Acid Ester Residues Against Influenza Virus A/IIV-Orenburg/83/2012(H1N1)pdm09." Molecules 29, no. 24 (2024): 5886. https://doi.org/10.3390/molecules29245886.

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New derivatives of the closo-decaborate anion [B10H9–O(CH2)2O(CH2)3C(O)–L–OCH3]2− (An) (1: L = Trp; 2: L = His; 3: L = Met; 4: L = Ala(2-oxopyrrolidin-3-yl) (Pld) were synthesized and isolated as tetraphenylphosphonium salts (Ph4P)2An. Anions 12−; 22−; 32−, and 42− contain a pendant functional group from the L-tryptophan methyl ester, L-histidine methyl ester, L-methionine methyl ester, or methyl 2-amino-3-(2-oxopyrrolidin-3-yl)propanoate (-Trp–OCH3, -His–OCH3, -Met–OCH3, or -Pld–OCH3) residue, respectively, bonded with the boron cluster anion through the oxybis[(ethane-2,1-diyl)oxy] spacer. T

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35

Dronova, M. L., Z. S. Suvorova, and Yu V. Korotkyi. "Relationship of antimicrobial activity and chemical structure of the arylaliphatic aminoalcohol derivatives." Farmatsevtychnyi zhurnal, no. 5 (September 4, 2018): 95–104. http://dx.doi.org/10.32352/0367-3057.5.15.06.

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Arylaliphatic aminoalcohols appeared to be the new promising class of compounds for the development of antibacterial and antifungal agents. The aim of the presented study was to analyze the «chemical structure-antimicrobial activity» relationship for further activity-directed synthesis of compounds of this class. The antimicrobial activity of the compounds was investigated by serial broth dilution method. Primary analysis of the effect of substituents’ structure on the ability of the derivatives to inhibit the growth of test-microorganisms was carried out by empirical method. Molecular s

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Rádl, Stanislav, Petr Hezký, Petr Konvička, and Ivan Krejčí. "Synthesis and Analgesic Activity of Some Substituted 1-Benzofurans and 1-Benzothiophenes." Collection of Czechoslovak Chemical Communications 65, no. 7 (2000): 1093–108. http://dx.doi.org/10.1135/cccc20001093.

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2-Benzoyl- and 2-(pyridylcarbonyl)-1-benzofuran-3-amines were prepared from 2-hydroxybenzonitrile and corresponding bromoethanone derivatives. 2-Benzoyl- and 2-(pyridylcarbonyl)-1-benzothiophene-3-amines were prepared analogously from 2-sulfanylbenzonitrile. 2-Benzoyl-1-benzofuran-3-amine treated with acetic anhydride or ethyl chloroformate provided the corresponding N-acetyl or N-ethoxycarbonyl derivatives. These N-activated compounds were alkylated with ethyl bromoacetate to provide ethyl N-acetyl-N-(2-benzoyl-1-benzofuran-3-yl)glycinate and ethyl N-(2-benzoyl-1-benzofuran-3-yl)-N-ethoxycarb

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37

Bakheit, Ahmed H., Mohamed W. Attwa, Adnan A. Kadi, and Hamad M. Alkahtani. "Structural Analysis and Reactivity Insights of (E)-Bromo-4-((4-((1-(4-chlorophenyl)ethylidene)amino)-5-phenyl-4H-1,2,4-triazol-3-yl)thio)-5-((2-isopropylcyclohexyl)oxy) Furan-2(5H)-one: A Combined Approach Using Single-Crystal X-ray Diffraction, Hirshfeld Surface Analysis, and Conceptual Density Functional Theory." Crystals 13, no. 9 (2023): 1313. http://dx.doi.org/10.3390/cryst13091313.

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This study presents a comprehensive exploration of the structure–reactivity relationship of (E)-3-bromo-4-((4-((1-(4-chlorophenyl)ethylidene)amino)-5-phenyl-4H-1,2,4-triazol-3-yl)thio)-5-((2-isopropylcyclohexyl)oxy)furan-2(5H)-one. The study embarked on an in-depth investigation into the solid-state crystal structure of this organic compound, employing computational Density Functional Theory (DFT) and related methodologies, which have not extensively been used in the examination of such compounds. A single-crystal X-ray diffraction (SCXRD) analysis was initially performed, supplemented by a Hi

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38

Utami, Sri, Mokhamad Fahmi Rizki Syaban, Diana Yuswanti Putri, Victor Alvianoes Guterez Hose, Husnul Khotimah, and Yuyun Yueniwati. "Bioinformatics Examination of Quercetin from Salacca zalacca Skin, Fruit, and Seed as a Potent Active Compounds Against Hypercholesterolemia Via PCSK9 Inhibition." Trends in Sciences 22, no. 4 (2025): 9237. https://doi.org/10.48048/tis.2025.9237.

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Hypercholesterolemia is a high-risk factor for cardiovascular disease. The increasing prevalence of hypercholesterolemia necessitates effective therapy. One of the novel targets is proprotein convertase subtilisin/kexin type 9 (PCSK9). However, the high cost of PCSK9 inhibitors limits their availability in low-income and middle-income countries. Salacca zalacca (SZ) is an herbal plant with various pharmacological properties, especially cholesterol metabolism. Novel PCSK9 inhibitors from herbal plants may be promising for drug development based on bioinformatic predictive analysis. This study i

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Derafa, Wassila, Nadia A.A. Elkanzi, Ali M. Ali, and Aly Abdou. "Three Co(II), Ni(II) and Cu(II) Schiff base complexes incorporating 2-[(4-{[(4-methylphenyl)sulfonothioyl]oxy}phenyl)methylene] amino}benzoic acid: Synthesis, structural, dft, biological and molecular docking investigation." Bulletin of the Chemical Society of Ethiopia 38, no. 2 (2024): 325–46. http://dx.doi.org/10.4314/bcse.v38i2.5.

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New 2-[(4-[(4-methylphenyl)sulfonothioyl)methylene]aminobenzoic acid ligand-Co(II), Ni(II), and Cu(II) complexes are synthesized and characterized in this article. Elemental analysis, mass spectroscopy, conductivity tests, magnetic susceptibility, Fourier transform infrared spectroscopy, thermogravimetric analysis, electronic absorption spectroscopy, and density functional theory calculations were used to determine the coordination mode, and geometry of the synthesized compounds. The Schiff-base ligand was shown to be mono-negatively charged and coordinate to metal ions in a bi-dentate mode th

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40

Chalbot, Marie-Cecile G., and Ilias G. Kavouras. "Nuclear Magnetic Resonance Characterization of Water Soluble Organic Carbon of Atmospheric Aerosol Types." Natural Product Communications 14, no. 5 (2019): 1934578X1984997. http://dx.doi.org/10.1177/1934578x19849972.

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The water soluble organic carbon of the prevalent atmospheric aerosol sources (traffic exhausts, paved road dust, agricultural soil, native soil, wood combustion, epicuticular waxes from pine and broad-leaved trees, and pollen) has been characterized using 1H (1-dimensional), 1H-1H-correlation spectroscopy and 1H-13C-heteronuclear single quantum correlation 2-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopy. Traffic exhaust particles were mainly constituted of primary alcohols, carbohydrates, functionalized olefins, C3 and C4 oxy- and hydroxyl-carboxylic acids, and short-chain al

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41

Berger, Louise C., Judith Wilson, Pamela Wood, and Bradley J. Berger. "Methionine Regeneration and Aspartate Aminotransferase in Parasitic Protozoa." Journal of Bacteriology 183, no. 15 (2001): 4421–34. http://dx.doi.org/10.1128/jb.183.15.4421-4434.2001.

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ABSTRACT Aspartate aminotransferases have been cloned and expressed fromCrithidia fasciculata, Trypanosoma brucei brucei, Giardia intestinalis, andPlasmodium falciparum and have been found to play a role in the final step of methionine regeneration from methylthioadenosine. All five enzymes contain sequence motifs consistent with membership in the Ia subfamily of aminotransferases; the crithidial and giardial enzymes and one trypanosomal enzyme were identified as cytoplasmic aspartate aminotransferases, and the second trypanosomal enzyme was identified as a mitochondrial aspartate aminotransfe

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42

Hayashi, Yoshiharu. "Synthesis and selective herbicidal activity of methyl (E,Z)-[[[1-[5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrophenyl]-2-methoxyethylidene]amino]oxy]acetate and analogous compounds." Journal of Agricultural and Food Chemistry 38, no. 3 (1990): 839–44. http://dx.doi.org/10.1021/jf00093a053.

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43

Cao, Liwei, Hong Wang, and Huashan Zhang. "Analytical potential of 6-oxy-(N-succinimidyl acetate)-9-(2'-methoxycarbonyl) fluorescein for the determination of amino compounds by capillary electrophoresis with laser-induced fluorescence detection." ELECTROPHORESIS 26, no. 10 (2005): 1954–62. http://dx.doi.org/10.1002/elps.200410227.

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44

Mali, Suraj N., Sudhir Sawant, Hemchandra K. Chaudhari, and Mustapha C. Mandewale. "In Silico Appraisal, Synthesis, Antibacterial Screening and DNA Cleavage for 1,2,5-thiadiazole Derivative." Current Computer-Aided Drug Design 15, no. 5 (2019): 445–55. http://dx.doi.org/10.2174/1573409915666190206142756.

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Background: : Thiadiazole not only acts as “hydrogen binding domain” and “two-electron donor system” but also as constrained pharmacophore. Methods:: The maleate salt of 2-((2-hydroxy-3-((4-morpholino-1, 2,5-thiadiazol-3-yl) oxy) propyl) amino)- 2-methylpropan-1-ol (TML-Hydroxy)(4) has been synthesized. This methodology involves preparation of 4-morpholino-1, 2,5-thiadiazol-3-ol by hydroxylation of 4-(4-chloro-1, 2,5-thiadiazol-3-yl) morpholine followed by condensation with 2-(chloromethyl) oxirane to afford 4-(4-(oxiran-2-ylmethoxy)-1,2,5-thiadiazol- 3-yl) morpholine. Oxirane ring of this com

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45

Aziz, Mubashir, Muhammad Sarfraz, Muhammad Khurrum Ibrahim, et al. "Evaluation of anticancer potential of tetracene-5,12-dione (A01) and pyrimidine-2,4-dione (A02) via caspase 3 and lactate dehydrogenase cytotoxicity investigations." PLOS ONE 18, no. 12 (2023): e0292455. http://dx.doi.org/10.1371/journal.pone.0292455.

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Cancer stands as a significant global cause of mortality, predominantly arising from the dysregulation of key enzymes and DNA. One strategic avenue in developing new anticancer agents involves targeting specific proteins within the cancer pathway. Amidst ongoing efforts to enhance the efficacy of anticancer drugs, a range of crucial medications currently interact with DNA at the molecular level, exerting profound biological effects. Our study is driven by the objective to comprehensively explore the potential of two compounds: (7S,9S)-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,

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46

Rizak, Galina. "SEARCH FOR BİOLOGİCALLY ACTİVE SUBSTANCES USİNG THE EXAMPLE OF 2.4-DIOXO- AND 4-IMINO-2-OXO- 3-PHENYL-5-R-6-R`-THIENO[2.3-D]PYRIMIDINES, ROSPECTS FOR THEİR USE İN PHARMACY AND MEDİCİNE." Azerbaijan Pharmaceutical and Pharmacoterapy Journal 23, no. 1 (2023): 29–46. http://dx.doi.org/10.58495/bucc4973.

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The purpose of this paper was the development of new bioactive substances – derivatives of 2.4-dioxo- and 4-imino-2-oxo-3-phenyl-5-R-6-R`-thieno[2.3-d]pyrimidines; researching the structure of invented substances and conducting their pharmacological analysis. Such research methods were used as synthesis of ethyl 4-R-5-R`-2-aminothiophene-3-carboxylates, nitriles of 4- R-5-R`-2-aminothiophene-3-carboxylic acids, their ureide derivatives 2.4-dioxo- and 4-imino-2- oxo-3-phenyl-5-R-6-R`-thieno[2.3-d]pyrimidines, their alkyl, acyl and cyanoethyl derivatives and products of their chemical transforma

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47

Rossmann, Michael. "The first protein Structure Determinations." Acta Crystallographica Section A Foundations and Advances 70, a1 (2014): C1801. http://dx.doi.org/10.1107/s2053273314081996.

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Max Perutz had been studying the structure of haemoglobin for 21 years using highly original and creative techniques, when I arrived in Cambridge in the summer of 1958. Most recently he had explored the use of isomorphous replacement by substituting specific amino acids with heavy metal compounds. Together with Ann Cullis, he had collected three dimensional diffraction data on native haemoglobin crystals and on three heavy atom derivatives. But now Max needed help in analyzing this data. I had had experience in determining three small aromatic hydrocarbon structures as a graduate student with

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48

Al-Rubaye, Dr Abeer Fauzi Murad, and Dr Bashar Oda Jawad. "Analysis of Metabolites by GC-MS and FTIR Spectroscopy Techniques to Ethanolic Whole Plant Extract from Thymus Vulgaris and Assessment of its Antibacterial Potency." South Asian Research Journal of Applied Medical Sciences 7, no. 04 (2025): 158–68. https://doi.org/10.36346/sarjams.2025.v07i04.008.

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Background: The use of medicinal plants has been crucial in the treatment of a wide range of illnesses. The medicinal herb thymus vulgaris has a long history of biological and pharmacological applications. Small chemicals called metabolites are involved in metabolic activities that are critical for the growth, maintenance, and function of cells. Metabolite concentrations typically span multiple orders of magnitude, and their molecular weights are typically 50–1500 Da. Metabolites are quite sensitive to a wide range of environmental factors, and the metabolome is itself very dynamic and time-de

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Beltyukova, S. V., O. I. Teslyuk, and E. O. Liventsova. "EFFECT OF BOVINE SERUM ALBUMIN ON THE LUMINESCENT PROPERTIES OF FLAVONOIDS." Scientific Bulletin of the Uzhhorod University. Series «Chemistry» 46, no. 2 (2022): 35–40. http://dx.doi.org/10.24144/2414-0260.2021.2.35-40.

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Flavonoids, as representatives of the class of aromatic phenols, in the structure of which have several cyclic groups and form chelates with many metal ions. Quercetin, morin and rutin belong to the group of polyphenolic compounds that actively absorb ultraviolet light and have wide absorption bands with high values of molar absorption coefficients. Quercetin and morin in ethanolic solutions show their own intense luminescence. The luminescence intensity (Ilum) of rutin, in the 3-oxy group of which the hydrogen atom is replaced by rhamnose, is of little importance. In the presence of bov

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Akbar, Hafiz Sajid, Naveed Muhammad, Muhammad S. Jan, et al. "Design, Synthesis, Molecular Docking, and Anti‐Inflammatory Potential of Amide Coupling Carboxylate Derivatives." ChemistrySelect 9, no. 14 (2024). http://dx.doi.org/10.1002/slct.202303100.

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AbstractEight new amide‐based carboxylate derivatives were synthesized and evaluated for anti‐inflammatory potentials using in‐vitro, in‐vivo and in silico studies. In cyclooxygenase‐2 assay, maximum percent antagonist potential was exhibited by sodium 4‐((4‐fluorophenyl) amino)‐4‐oxobutanoate (93.91 %), bis ((4‐((4‐methoxy‐2‐nitrophenyl)amino)‐4‐oxobutanoyl)oxy) zinc (93.04 %), and bis ((4‐((4‐bromo‐2‐fluorophenyl) amino)‐4‐oxobutanoyl)oxy)zincio (2‐bromopyridine) (92.64 %) with IC50 values of 1.65, 2.08, and 0.288 μM/ml respectively. Celecoxib demonstrated 98.60 % effect with an IC50 value o

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