Relevant bibliographies by topics / Aminoglycosides – biosynthesis

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters

Academic literature on the topic 'Aminoglycosides – biosynthesis'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Aminoglycosides – biosynthesis"

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Ban, Yeon Hee, Myoung Chong Song, Je Won Park, and Yeo Joon Yoon. "Minor components of aminoglycosides: recent advances in their biosynthesis and therapeutic potential." Natural Product Reports 37, no. 3 (2020): 301–11. http://dx.doi.org/10.1039/c9np00041k.

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This Highlight covers the recent advances in the biosynthetic pathways of aminoglycosides including their minor components, together with the therapeutic potential for minor aminoglycoside components and semi-synthetic aminoglycosides.
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Ezraty, Benjamin, Alexandra Vergnes, Manuel Banzhaf, et al. "Fe-S Cluster Biosynthesis Controls Uptake of Aminoglycosides in a ROS-Less Death Pathway." Science 340, no. 6140 (2013): 1583–87. http://dx.doi.org/10.1126/science.1238328.

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All bactericidal antibiotics were recently proposed to kill by inducing reactive oxygen species (ROS) production, causing destabilization of iron-sulfur (Fe-S) clusters and generating Fenton chemistry. We find that the ROS response is dispensable upon treatment with bactericidal antibiotics. Furthermore, we demonstrate that Fe-S clusters are required for killing only by aminoglycosides. In contrast to cells, using the major Fe-S cluster biosynthesis machinery, ISC, cells using the alternative machinery, SUF, cannot efficiently mature respiratory complexes I and II, resulting in impendence of t
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Yu, Yi, Qi Zhang, and Zixin Deng. "Parallel pathways in the biosynthesis of aminoglycoside antibiotics." F1000Research 6 (May 18, 2017): 723. http://dx.doi.org/10.12688/f1000research.11104.1.

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Despite their inherent toxicity and the global spread of bacterial resistance, aminoglycosides (AGs), an old class of microbial drugs, remain a valuable component of the antibiotic arsenal. Recent studies have continued to reveal the fascinating biochemistry of AG biosynthesis and the rich potential in their pathway engineering. In particular, parallel pathways have been shown to be common and widespread in AG biosynthesis, highlighting nature’s ingenuity in accessing diverse natural products from a limited set of genes. In this review, we discuss the parallel biosynthetic pathways of three re
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Krahn, Thomas, Christie Gilmour, Justin Tilak, et al. "Determinants of Intrinsic Aminoglycoside Resistance in Pseudomonas aeruginosa." Antimicrobial Agents and Chemotherapy 56, no. 11 (2012): 5591–602. http://dx.doi.org/10.1128/aac.01446-12.

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ABSTRACTScreening of a transposon insertion mutant library ofPseudomonas aeruginosafor increased susceptibility to paromomycin identified a number of genes whose disruption enhanced susceptibility of this organism to multiple aminoglycosides, including tobramycin, amikacin, and gentamicin. These included genes associated with lipid biosynthesis or metabolism (lptA,faoA), phosphate uptake (pstB), and two-component regulators (amgRS, PA2797-PA2798) and a gene of unknown function (PA0392). Deletion mutants lacking these showed enhanced panaminoglycoside susceptibility that was reversed by the clo
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Mitousis, Lena, Hannes Maier, Luka Martinovic, et al. "Engineering of Streptoalloteichus tenebrarius 2444 for Sustainable Production of Tobramycin." Molecules 26, no. 14 (2021): 4343. http://dx.doi.org/10.3390/molecules26144343.

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Tobramycin is a broad-spectrum aminoglycoside antibiotic agent. The compound is obtained from the base-catalyzed hydrolysis of carbamoyltobramycin (CTB), which is naturally produced by the actinomycete Streptoalloteichus tenebrarius. However, the strain uses the same precursors to synthesize several structurally related aminoglycosides. Consequently, the production yields of tobramycin are low, and the compound’s purification is very challenging, costly, and time-consuming. In this study, the production of the main undesired product, apramycin, in the industrial isolate Streptoalloteichus tene
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Urbanek, Dorota A., Ewgenij Proschak, Yusuf Tanrikulu, Steffi Becker, Michael Karas, and Gisbert Schneider. "Scaffold-hopping from aminoglycosides to small synthetic inhibitors of bacterial protein biosynthesis using a pseudoreceptor model." MedChemComm 2, no. 3 (2011): 181. http://dx.doi.org/10.1039/c0md00207k.

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Malott, Rebecca J., Barbara R. Steen-Kinnaird, Tracy D. Lee, and David P. Speert. "Identification of Hopanoid Biosynthesis Genes Involved in Polymyxin Resistance in Burkholderia multivorans." Antimicrobial Agents and Chemotherapy 56, no. 1 (2011): 464–71. http://dx.doi.org/10.1128/aac.00602-11.

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ABSTRACTA major challenge to clinical therapy ofBurkholderia cepaciacomplex (Bcc) pulmonary infections is their innate resistance to a broad range of antimicrobials, including polycationic agents such as aminoglycosides, polymyxins, and cationic peptides. To identify genetic loci associated with this phenotype, a transposon mutant library was constructed inB. multivoransATCC 17616 and screened for increased susceptibility to polymyxin B. Compared to the parent strain, mutant 26D7 exhibited 8- and 16-fold increases in susceptibility to polymyxin B and colistin, respectively. Genetic analysis of
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Kumar B, Abishek, Bency Thankappan, Angayarkanni Jayaraman, and Akshita Gupta. "Evaluation of Antibiotic Tolerance in Pseudomonas aeruginosa for Aminoglycosides and Its Predicted Gene Regulations through In-Silico Transcriptomic Analysis." Microbiology Research 12, no. 3 (2021): 630–45. http://dx.doi.org/10.3390/microbiolres12030045.

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Pseudomonas aeruginosa causes chronic infections, such as cystic fibrosis, endocarditis, bacteremia, and sepsis, which are life-threatening and difficult to treat. The lack of antibiotic response in P. aeruginosa is due to adaptive resistance mechanism, which prevents the entry of antibiotics into the cytosol of the cell to achieve tolerance. Among the different groups of antibiotics, aminoglycosides are used as a parenteral antibiotic for the treatment of P. aeruginosa. This study aimed to determine the kinetics of antibiotic tolerance and gene expression changes in P. aeruginosa exposed to a
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Hobbie, Sven N., Peter Pfister, Christian Brüll, Eric Westhof, and Erik C. Böttger. "Analysis of the Contribution of Individual Substituents in 4,6-Aminoglycoside-Ribosome Interaction." Antimicrobial Agents and Chemotherapy 49, no. 12 (2005): 5112–18. http://dx.doi.org/10.1128/aac.49.12.5112-5118.2005.

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ABSTRACT The 4,6-disubstituted 2-deoxystreptamines interfere with protein biosynthesis by specifically targeting the ribosomal A site. These drugs show subtle variations in the chemical groups of rings I, II, and III. In the present study we used site-directed mutagenesis to generate mutant strains of Mycobacterium smegmatis mc2155 SMR5 ΔrrnB with mutations in its single rRNA allele, rrnA. This genetic procedure gives rise to strains carrying homogeneous populations of mutant ribosomes and was used to study the contribution of individual chemical substituents to the binding of 4,6-disubstitute
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Kumar, Nitin, Chih-Chia Su, Tsung-Han Chou, et al. "Crystal structures of the Burkholderia multivorans hopanoid transporter HpnN." Proceedings of the National Academy of Sciences 114, no. 25 (2017): 6557–62. http://dx.doi.org/10.1073/pnas.1619660114.

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Strains of the Burkholderia cepacia complex (Bcc) are Gram-negative opportunisitic bacteria that are capable of causing serious diseases, mainly in immunocompromised individuals. Bcc pathogens are intrinsically resistant to multiple antibiotics, including β-lactams, aminoglycosides, fluoroquinolones, and polymyxins. They are major pathogens in patients with cystic fibrosis (CF) and can cause severe necrotizing pneumonia, which is often fatal. Hopanoid biosynthesis is one of the major mechanisms involved in multiple antimicrobial resistance of Bcc pathogens. The hpnN gene of B. multivorans enco
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Dissertations / Theses on the topic "Aminoglycosides – biosynthesis"

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Fan-Minogue, Hua. "Understanding the molecular mechanism of eukaryotic translation termination functional analysis of ribosomal RNA and eukaryotic release factor one /." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2009r/fan-minogue.pdf.

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Reva, Anna. "Enzymology of gentamicin biosynthesis." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/277902.

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Gentamicin C complex is a mixture of five structurally similar aminoglycoside antibiotics, gentamicins C1, C1a, C2, C2a, and C2b, produced by the actinomycete bacterium Micromonospora echinospora. It is established in clinical use and despite significant toxicity remains valuable to treat severe Gram-negative bacterial infections. There is a pressing need to develop novel versions of such antibiotics to combat the rise of resistance among pathogens. Engineering of the pathway requires a detailed knowledge of the genes, enzymes, and intermediates involved. The final steps of gentamicin biosynth
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Fan, Q. "Genetic and biochemical studies of the biosynthesis of glycopeptide and aminoglycoside antibiotics." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598931.

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My project explored the biosynthesis of teicoplanin and neomycin as representatives of glycopeptides and aminoglycosides respectively, with a focus on the characterisation of the biosynthetic enzymes and the development of methods for targeted gene disruption in the producer strains. Both <i>Actinoplanes teichomyceticus </i>ATCC 31121, the teicoplanin producer, and <i>Streptomyces fradiae </i>NCIMB 8233, the neomycin producer, were successfully conjugated. This allowed <i>in vivo</i> study of specific enzymes involved in the biosynthetic pathway. Several aspects of teicoplanin biosynthesis wer
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"Synthetic studies of pseudoaminodisaccharides." 1999. http://library.cuhk.edu.hk/record=b6073208.

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by Stanton Hon-Lung Kok.<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 1999.<br>Includes bibliographical references (p. 142-147).<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Mode of access: World Wide Web.<br>Abstracts in English and Chinese.
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Aboshanab, Khaled Mohamed Anwar [Verfasser]. "Genetic studies on the biosynthesis of the major aminoglycoside antibiotics : isolation, analysis and comparison of the biosynthetic gene clusters for 12 aminoglycoside antibiotics / presented by Khaled Mohamed Anwar Aboshanab." 2005. http://d-nb.info/98288706X/34.

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Nasim, Md Talat, A. Ghouri, B. Patel, et al. "Stoichiometric imbalance in the receptor complex contributes to dysfunctional BMPR-II mediated signalling in pulmonary arterial hypertension." 2008. http://hdl.handle.net/10454/6113.

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Heterozygous germline defects in a gene encoding a type II receptor for bone morphogenetic proteins (BMPR-II) underlie the majority of inherited cases of the vascular disorder known as pulmonary arterial hypertension (PAH). However, the precise molecular consequences of PAH causing mutations on the function of the receptor complex remain unclear. We employed novel enzymatic and fluorescence activity based techniques to assess the impact of PAH mutations on pre-mRNA splicing, nonsense-mediated decay (NMD) and receptor complex interactions. We demonstrate that nonsense and frameshift mutations t
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Book chapters on the topic "Aminoglycosides – biosynthesis"

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Kudo, Fumitaka. "Biosynthesis of Aminoglycoside Antibiotics." In Comprehensive Natural Products III. Elsevier, 2020. http://dx.doi.org/10.1016/b978-0-12-409547-2.14619-0.

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Wehmeier, Udo F., and Wolfgang Piepersberg. "Chapter 19 Enzymology of Aminoglycoside Biosynthesis—Deduction from Gene Clusters." In Methods in Enzymology. Elsevier, 2009. http://dx.doi.org/10.1016/s0076-6879(09)04619-9.

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Kudo, Fumitaka, and Tadashi Eguchi. "Chapter 20 Biosynthetic Enzymes for the Aminoglycosides Butirosin and Neomycin." In Methods in Enzymology. Elsevier, 2009. http://dx.doi.org/10.1016/s0076-6879(09)04620-5.

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Journal articles
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