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Journal articles on the topic 'Aminoglycosides – biosynthesis'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Ban, Yeon Hee, Myoung Chong Song, Je Won Park, and Yeo Joon Yoon. "Minor components of aminoglycosides: recent advances in their biosynthesis and therapeutic potential." Natural Product Reports 37, no. 3 (2020): 301–11. http://dx.doi.org/10.1039/c9np00041k.

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This Highlight covers the recent advances in the biosynthetic pathways of aminoglycosides including their minor components, together with the therapeutic potential for minor aminoglycoside components and semi-synthetic aminoglycosides.

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2

Ezraty, Benjamin, Alexandra Vergnes, Manuel Banzhaf, et al. "Fe-S Cluster Biosynthesis Controls Uptake of Aminoglycosides in a ROS-Less Death Pathway." Science 340, no. 6140 (2013): 1583–87. http://dx.doi.org/10.1126/science.1238328.

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All bactericidal antibiotics were recently proposed to kill by inducing reactive oxygen species (ROS) production, causing destabilization of iron-sulfur (Fe-S) clusters and generating Fenton chemistry. We find that the ROS response is dispensable upon treatment with bactericidal antibiotics. Furthermore, we demonstrate that Fe-S clusters are required for killing only by aminoglycosides. In contrast to cells, using the major Fe-S cluster biosynthesis machinery, ISC, cells using the alternative machinery, SUF, cannot efficiently mature respiratory complexes I and II, resulting in impendence of t

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3

Yu, Yi, Qi Zhang, and Zixin Deng. "Parallel pathways in the biosynthesis of aminoglycoside antibiotics." F1000Research 6 (May 18, 2017): 723. http://dx.doi.org/10.12688/f1000research.11104.1.

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Despite their inherent toxicity and the global spread of bacterial resistance, aminoglycosides (AGs), an old class of microbial drugs, remain a valuable component of the antibiotic arsenal. Recent studies have continued to reveal the fascinating biochemistry of AG biosynthesis and the rich potential in their pathway engineering. In particular, parallel pathways have been shown to be common and widespread in AG biosynthesis, highlighting nature’s ingenuity in accessing diverse natural products from a limited set of genes. In this review, we discuss the parallel biosynthetic pathways of three re

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4

Krahn, Thomas, Christie Gilmour, Justin Tilak, et al. "Determinants of Intrinsic Aminoglycoside Resistance in Pseudomonas aeruginosa." Antimicrobial Agents and Chemotherapy 56, no. 11 (2012): 5591–602. http://dx.doi.org/10.1128/aac.01446-12.

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ABSTRACTScreening of a transposon insertion mutant library ofPseudomonas aeruginosafor increased susceptibility to paromomycin identified a number of genes whose disruption enhanced susceptibility of this organism to multiple aminoglycosides, including tobramycin, amikacin, and gentamicin. These included genes associated with lipid biosynthesis or metabolism (lptA,faoA), phosphate uptake (pstB), and two-component regulators (amgRS, PA2797-PA2798) and a gene of unknown function (PA0392). Deletion mutants lacking these showed enhanced panaminoglycoside susceptibility that was reversed by the clo

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5

Mitousis, Lena, Hannes Maier, Luka Martinovic, et al. "Engineering of Streptoalloteichus tenebrarius 2444 for Sustainable Production of Tobramycin." Molecules 26, no. 14 (2021): 4343. http://dx.doi.org/10.3390/molecules26144343.

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Tobramycin is a broad-spectrum aminoglycoside antibiotic agent. The compound is obtained from the base-catalyzed hydrolysis of carbamoyltobramycin (CTB), which is naturally produced by the actinomycete Streptoalloteichus tenebrarius. However, the strain uses the same precursors to synthesize several structurally related aminoglycosides. Consequently, the production yields of tobramycin are low, and the compound’s purification is very challenging, costly, and time-consuming. In this study, the production of the main undesired product, apramycin, in the industrial isolate Streptoalloteichus tene

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6

Urbanek, Dorota A., Ewgenij Proschak, Yusuf Tanrikulu, Steffi Becker, Michael Karas, and Gisbert Schneider. "Scaffold-hopping from aminoglycosides to small synthetic inhibitors of bacterial protein biosynthesis using a pseudoreceptor model." MedChemComm 2, no. 3 (2011): 181. http://dx.doi.org/10.1039/c0md00207k.

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7

Malott, Rebecca J., Barbara R. Steen-Kinnaird, Tracy D. Lee, and David P. Speert. "Identification of Hopanoid Biosynthesis Genes Involved in Polymyxin Resistance in Burkholderia multivorans." Antimicrobial Agents and Chemotherapy 56, no. 1 (2011): 464–71. http://dx.doi.org/10.1128/aac.00602-11.

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ABSTRACTA major challenge to clinical therapy ofBurkholderia cepaciacomplex (Bcc) pulmonary infections is their innate resistance to a broad range of antimicrobials, including polycationic agents such as aminoglycosides, polymyxins, and cationic peptides. To identify genetic loci associated with this phenotype, a transposon mutant library was constructed inB. multivoransATCC 17616 and screened for increased susceptibility to polymyxin B. Compared to the parent strain, mutant 26D7 exhibited 8- and 16-fold increases in susceptibility to polymyxin B and colistin, respectively. Genetic analysis of

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8

Kumar B, Abishek, Bency Thankappan, Angayarkanni Jayaraman, and Akshita Gupta. "Evaluation of Antibiotic Tolerance in Pseudomonas aeruginosa for Aminoglycosides and Its Predicted Gene Regulations through In-Silico Transcriptomic Analysis." Microbiology Research 12, no. 3 (2021): 630–45. http://dx.doi.org/10.3390/microbiolres12030045.

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Pseudomonas aeruginosa causes chronic infections, such as cystic fibrosis, endocarditis, bacteremia, and sepsis, which are life-threatening and difficult to treat. The lack of antibiotic response in P. aeruginosa is due to adaptive resistance mechanism, which prevents the entry of antibiotics into the cytosol of the cell to achieve tolerance. Among the different groups of antibiotics, aminoglycosides are used as a parenteral antibiotic for the treatment of P. aeruginosa. This study aimed to determine the kinetics of antibiotic tolerance and gene expression changes in P. aeruginosa exposed to a

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9

Hobbie, Sven N., Peter Pfister, Christian Brüll, Eric Westhof, and Erik C. Böttger. "Analysis of the Contribution of Individual Substituents in 4,6-Aminoglycoside-Ribosome Interaction." Antimicrobial Agents and Chemotherapy 49, no. 12 (2005): 5112–18. http://dx.doi.org/10.1128/aac.49.12.5112-5118.2005.

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ABSTRACT The 4,6-disubstituted 2-deoxystreptamines interfere with protein biosynthesis by specifically targeting the ribosomal A site. These drugs show subtle variations in the chemical groups of rings I, II, and III. In the present study we used site-directed mutagenesis to generate mutant strains of Mycobacterium smegmatis mc2155 SMR5 ΔrrnB with mutations in its single rRNA allele, rrnA. This genetic procedure gives rise to strains carrying homogeneous populations of mutant ribosomes and was used to study the contribution of individual chemical substituents to the binding of 4,6-disubstitute

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10

Kumar, Nitin, Chih-Chia Su, Tsung-Han Chou, et al. "Crystal structures of the Burkholderia multivorans hopanoid transporter HpnN." Proceedings of the National Academy of Sciences 114, no. 25 (2017): 6557–62. http://dx.doi.org/10.1073/pnas.1619660114.

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Strains of the Burkholderia cepacia complex (Bcc) are Gram-negative opportunisitic bacteria that are capable of causing serious diseases, mainly in immunocompromised individuals. Bcc pathogens are intrinsically resistant to multiple antibiotics, including β-lactams, aminoglycosides, fluoroquinolones, and polymyxins. They are major pathogens in patients with cystic fibrosis (CF) and can cause severe necrotizing pneumonia, which is often fatal. Hopanoid biosynthesis is one of the major mechanisms involved in multiple antimicrobial resistance of Bcc pathogens. The hpnN gene of B. multivorans enco

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11

Ahmed, Dalia, Laith Yaaqoob, and Sehand Arif. "Biosynthesis of TiO2 nanoparticles using prodigiosin and evaluating its antibacterial activity against biofilm producing MDR- Acinetobacter baumannii." Al-Anbar Journal of Veterinary Sciences 13, no. 2 (2020): 137–51. http://dx.doi.org/10.37940/ajvs.2020.13.2.13.

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A rising number of hospital infections were caused by multi drug resistant A.baumannii. This microorganism has become a big global concern for clinicians. This study aimed to evaluate the antimicrobial activity of biosynthesized TiO2 nanoparticles against biofilm producing multi drug resistant A. baumannii. Bacteria were isolated from burn wounds. The selected isolate was identified using the routine biochemical assays, viteck 2, and confirmed by PCR technique, targeting the 16S rRNA and blaOXA-51 genes. Antimicrobial susceptibility tests were performed using Viteck 2 system and the biofilm pr

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12

Macinga, David R., Gregory M. Cook, Robert K. Poole, and Philip N. Rather. "Identification and Characterization ofaarF, a Locus Required for Production of Ubiquinone inProvidencia stuartii and Escherichia coli and for Expression of 2′-N-Acetyltransferase inP. stuartii." Journal of Bacteriology 180, no. 1 (1998): 128–35. http://dx.doi.org/10.1128/jb.180.1.128-135.1998.

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ABSTRACT Providencia stuartii contains a chromosomal 2′-N-acetyltransferase [AAC(2′)-Ia] involved in the O acetylation of peptidoglycan. The AAC(2′)-Ia enzyme is also capable of acetylating and inactivating certain aminoglycosides and confers high-level resistance to these antibiotics when overexpressed. We report the identification of a locus in P. stuartii, designated aarF, that is required for the expression of AAC(2′)-Ia. Northern (RNA) analysis demonstrated thataac(2′)-Ia mRNA levels were dramatically decreased in aP. stuartii strain carrying anaarF::Cm disruption. TheaarF::Cm disruption

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13

Borodina, Irina, Charlotte Schöller, Anna Eliasson, and Jens Nielsen. "Metabolic Network Analysis of Streptomyces tenebrarius, a Streptomyces Species with an Active Entner-Doudoroff Pathway." Applied and Environmental Microbiology 71, no. 5 (2005): 2294–302. http://dx.doi.org/10.1128/aem.71.5.2294-2302.2005.

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ABSTRACT Streptomyces tenebrarius is an industrially important microorganism, producing an antibiotic complex that mainly consists of the aminoglycosides apramycin, tobramycin carbamate, and kanamycin B carbamate. When S. tenebrarius is used for industrial tobramycin production, kanamycin B carbamate is an unwanted by-product. The two compounds differ only by one hydroxyl group, which is present in kanamycin carbamate but is reduced during biosynthesis of tobramycin. 13C metabolic flux analysis was used for elucidating connections between the primary carbon metabolism and the composition of th

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14

Kudo, Fumitaka, and Tadashi Eguchi. "Biosynthetic genes for aminoglycoside antibiotics." Journal of Antibiotics 62, no. 9 (2009): 471–81. http://dx.doi.org/10.1038/ja.2009.76.

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15

Ali, Niyaz, Yinfu Lin, Zhen Qing, et al. "The Role of Agriculture in the Dissemination of Class 1 Integrons, Antimicrobial Resistance, and Diversity of Their Gene Cassettes in Southern China." Genes 11, no. 9 (2020): 1014. http://dx.doi.org/10.3390/genes11091014.

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Integrons are hot spots for acquiring gene cassettes from the environment and play a major role in the bacterial evolution and dissemination of antimicrobial resistance (AMR), thus posing a serious threat. There are currently studies on integrons and antibiotic resistance genes; however, the presence and association of integrons in different agricultural crops and their subsequent dissemination and role in AMR have not been reported previously. This study examines the abundance of integrons, their gene cassette diversity in various crop soils, and their role in the dissemination of AMR in the

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16

Llewellyn, Nicholas M., and Jonathan B. Spencer. "Biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics." Natural Product Reports 23, no. 6 (2006): 864. http://dx.doi.org/10.1039/b604709m.

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17

Tang, Wei, Zhengyan Guo, Zhenju Cao, et al. "d-Sedoheptulose-7-phosphate is a common precursor for the heptoses of septacidin and hygromycin B." Proceedings of the National Academy of Sciences 115, no. 11 (2018): 2818–23. http://dx.doi.org/10.1073/pnas.1711665115.

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Seven-carbon-chain–containing sugars exist in several groups of important bacterial natural products. Septacidin represents a group of l-heptopyranoses containing nucleoside antibiotics with antitumor, antifungal, and pain-relief activities. Hygromycin B, an aminoglycoside anthelmintic agent used in swine and poultry farming, represents a group of d-heptopyranoses–containing antibiotics. To date, very little is known about the biosynthesis of these compounds. Here we sequenced the genome of the septacidin producer and identified the septacidin gene cluster by heterologous expression. After det

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18

Walker, James B. "Enzymatic Synthesis of Aminoglycoside Antibiotics: Novel Adenosylmethionine:2-Deoxystreptamine N-Methyltransferase Activities in Hygromycin B- and Spectinomycin-Producing Streptomyces spp. and Uses of the Methylated Products." Applied and Environmental Microbiology 68, no. 5 (2002): 2404–10. http://dx.doi.org/10.1128/aem.68.5.2404-2410.2002.

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ABSTRACT Aminocyclitols structurally related to streptamine, a 1,3-diaminocyclitol, are common components of the RNA-binding aminoglycoside antibiotics. The respective aminocyclitol cores of hygromycin B and spectinomycin are N 3-methyl-2-deoxy-d-streptamine and N 1,N 3-dimethyl-2-epi-streptamine. Adenosyl[methyl-14C]methionine:2-deoxystreptamine N-methyltransferase activities were detected in extracts of early-stationary-phase mycelia of the hygromycin B producer Streptomyces hygroscopicus subsp. hygroscopicus ATCC 27438 and the spectinomycin producer Streptomyces flavopersicus ATCC 19756. Ex

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19

Park, Je Won, Yeon Hee Ban, Sang-Jip Nam, Sun-Shin Cha, and Yeo Joon Yoon. "Biosynthetic pathways of aminoglycosides and their engineering." Current Opinion in Biotechnology 48 (December 2017): 33–41. http://dx.doi.org/10.1016/j.copbio.2017.03.019.

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20

Manabe, Shino, and Yukishige Ito. "Mycothiol synthesis by an anomerization reaction through endocyclic cleavage." Beilstein Journal of Organic Chemistry 12 (February 22, 2016): 328–33. http://dx.doi.org/10.3762/bjoc.12.35.

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Mycothiol is found in Gram-positive bacteria, where it helps in maintaining a reducing intracellular environment and it plays an important role in protecting the cell from toxic chemicals. The inhibition of the mycothiol biosynthesis is considered as a treatment for tuberculosis. Mycothiol contains an α-aminoglycoside, which is difficult to prepare stereoselectively by a conventional glycosylation reaction. In this study, mycothiol was synthesized by an anomerization reaction from an easily prepared β-aminoglycoside through endocyclic cleavage.

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21

Flatt, Patricia M., and Taifo Mahmud. "Biosynthesis of aminocyclitol-aminoglycoside antibiotics and related compounds." Nat. Prod. Rep. 24, no. 2 (2007): 358–92. http://dx.doi.org/10.1039/b603816f.

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22

Shao, Lei, Junsheng Chen, Chunxia Wang, et al. "Characterization of a key aminoglycoside phosphotransferase in gentamicin biosynthesis." Bioorganic & Medicinal Chemistry Letters 23, no. 5 (2013): 1438–41. http://dx.doi.org/10.1016/j.bmcl.2012.12.064.

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23

Wong, C. H., M. C. Bryan, P. T. Nyffeler, H. Liu, and Eli Chapman. "Synthesis of carbohydrate-based antibiotics." Pure and Applied Chemistry 75, no. 2-3 (2003): 179–86. http://dx.doi.org/10.1351/pac200375020179.

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Tackling the problem of carbohydrate recognition is a subject of current interest. Our strategies in this regard include development of new methods for the synthesis of saccharides and sugar arrays for screening, design of d-peptides to target bacterial cell-surface sugars, preparation of mechanism-based inhibitors of the enzymes involved in the biosynthesis of saccharides and the synthesis of aminoglycoside mimetics to target RNA.

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24

Felnagle, Elizabeth A., Michelle R. Rondon, Andrew D. Berti, Heidi A. Crosby, and Michael G. Thomas. "Identification of the Biosynthetic Gene Cluster and an Additional Gene for Resistance to the Antituberculosis Drug Capreomycin." Applied and Environmental Microbiology 73, no. 13 (2007): 4162–70. http://dx.doi.org/10.1128/aem.00485-07.

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ABSTRACT Capreomycin (CMN) belongs to the tuberactinomycin family of nonribosomal peptide antibiotics that are essential components of the drug arsenal for the treatment of multidrug-resistant tuberculosis. Members of this antibiotic family target the ribosomes of sensitive bacteria and disrupt the function of both subunits of the ribosome. Resistance to these antibiotics in Mycobacterium species arises due to mutations in the genes coding for the 16S or 23S rRNA but can also arise due to mutations in a gene coding for an rRNA-modifying enzyme, TlyA. While Mycobacterium species develop resista

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Paradise, Michael R., Gregory Cook, Robert K. Poole, and Philip N. Rather. "Mutations in aarE, the ubiA Homolog of Providencia stuartii, Result in High-Level Aminoglycoside Resistance and Reduced Expression of the Chromosomal Aminoglycoside 2′-N-Acetyltransferase." Antimicrobial Agents and Chemotherapy 42, no. 4 (1998): 959–62. http://dx.doi.org/10.1128/aac.42.4.959.

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ABSTRACT The aarE1 allele was identified on the basis of the resulting phenotype of increased aminoglycoside resistance. TheaarE1 mutation also resulted in a small-colony phenotype and decreased levels of aac(2′)-Ia mRNA. The deduced AarE gene product displayed 61% amino acid identity to theEscherichia coli UbiA protein, an octaprenyltransferase required for the second step of ubiquinone biosynthesis. Complementation experiments in both Providencia stuartiiand E. coli demonstrated that aarE andubiA are functionally equivalent.

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26

Nepal, Keshav Kumar, Jin Cheol Yoo, and Jae Kyung Sohng. "Biosynthetic approach for the production of new aminoglycoside derivative." Journal of Bioscience and Bioengineering 110, no. 1 (2010): 109–12. http://dx.doi.org/10.1016/j.jbiosc.2010.01.005.

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27

Ogawara, Hiroshi. "Comparison of Antibiotic Resistance Mechanisms in Antibiotic-Producing and Pathogenic Bacteria." Molecules 24, no. 19 (2019): 3430. http://dx.doi.org/10.3390/molecules24193430.

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Antibiotic resistance poses a tremendous threat to human health. To overcome this problem, it is essential to know the mechanism of antibiotic resistance in antibiotic-producing and pathogenic bacteria. This paper deals with this problem from four points of view. First, the antibiotic resistance genes in producers are discussed related to their biosynthesis. Most resistance genes are present within the biosynthetic gene clusters, but some genes such as paromomycin acetyltransferases are located far outside the gene cluster. Second, when the antibiotic resistance genes in pathogens are compared

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NAGAYA, Atsushi, Satoko TAKEYAMA, and Hideyuki TAMEGAI. "Identification of Aminotransferase Genes for Biosynthesis of Aminoglycoside Antibiotics from Soil DNA." Bioscience, Biotechnology, and Biochemistry 69, no. 7 (2005): 1389–93. http://dx.doi.org/10.1271/bbb.69.1389.

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29

Wang, Jinxiu, Suze Ma, Wei Ding, Tuo Chen, and Qi Zhang. "Mechanistic Study of Oxidoreductase AprQ Involved in Biosynthesis of Aminoglycoside Antibiotic Apramycin." Chinese Journal of Chemistry 39, no. 7 (2021): 1923–26. http://dx.doi.org/10.1002/cjoc.202100070.

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30

Lewandowska-Skarbek, Marlena, and Richard Hutchinson. "Phenotypic Suppression by Aminoglycoside Antibiotics of Mutations Blocking Erythromycin Biosynthesis in Saccharopolyspora erythraea." Journal of Bacteriology 172, no. 11 (1990): 6605–6. http://dx.doi.org/10.1128/jb.172.11.6605-6606.1990.

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31

Kudo, Fumitaka, and Tadashi Eguchi. "Aminoglycoside Antibiotics: New Insights into the Biosynthetic Machinery of Old Drugs." Chemical Record 16, no. 1 (2015): 4–18. http://dx.doi.org/10.1002/tcr.201500210.

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32

TAMEGAI, Hideyuki, Yumi KANDA, and Chiaki KATO. "Genes Encoding Carbocycle-Forming Enzymes Involved in Aminoglycoside Biosynthesis in Deep-Sea Environmental DNA." Bioscience, Biotechnology, and Biochemistry 74, no. 5 (2010): 1102–5. http://dx.doi.org/10.1271/bbb.90901.

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Lv, Meinan, Xinjian Ji, Junfeng Zhao, et al. "Characterization of a C3 Deoxygenation Pathway Reveals a Key Branch Point in Aminoglycoside Biosynthesis." Journal of the American Chemical Society 138, no. 20 (2016): 6427–35. http://dx.doi.org/10.1021/jacs.6b02221.

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34

Lyos, Andrew T., William E. Winter, and Charles M. Henley. "Kanamycin Inhibits Cochlear-Renal ODC in Neonatal Rats." Otolaryngology–Head and Neck Surgery 107, no. 4 (1992): 501–10. http://dx.doi.org/10.1177/019459989210700401.

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Ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis, is important in development and regeneration. We hypothesize that aminoglycoside inhibition of ODC mediates developmental hypersensitivity to aminoglycoside ototoxicity. Kanamycin effects on ODC activity (decarboxylation of ornithine) in vitro were determined in the postmitochondriai fraction of cochlear and renal homogenates from 11-day-old rats. Kanamycin inhibited cochlear and renal ODC by an uncompetitive mechanism. For the cochlear enzyme, the inhibitor constant (Ki) for kanamycin was 99 ± 25 (μmol/L; for the renal enz

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Bury, Priscila dos Santos, Fanglu Huang, Sicong Li, Yuhui Sun, Peter F. Leadlay, and Marcio Vinicius Bertacine Dias. "Structural Basis of the Selectivity of GenN, an Aminoglycoside N-Methyltransferase Involved in Gentamicin Biosynthesis." ACS Chemical Biology 12, no. 11 (2017): 2779–87. http://dx.doi.org/10.1021/acschembio.7b00466.

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Thapa, L. P., T. J. Oh, K. Liou, and J. K. Sohng. "Biosynthesis of spectinomycin: heterologous production of spectinomycin and spectinamine in an aminoglycoside-deficient host,Streptomyces venezuelaeYJ003." Journal of Applied Microbiology 105, no. 1 (2008): 300–308. http://dx.doi.org/10.1111/j.1365-2672.2008.03788.x.

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Kim, Kyoung-Rok, Tae-Jong Kim, and Joo-Won Suh. "The Gene Cluster for Spectinomycin Biosynthesis and the Aminoglycoside-Resistance Function of spcM in Streptomyces spectabilis." Current Microbiology 57, no. 4 (2008): 371–74. http://dx.doi.org/10.1007/s00284-008-9204-y.

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Clements, Mark O., Sean P. Watson, Robert K. Poole, and Simon J. Foster. "CtaA of Staphylococcus aureus Is Required for Starvation Survival, Recovery, and Cytochrome Biosynthesis." Journal of Bacteriology 181, no. 2 (1999): 501–7. http://dx.doi.org/10.1128/jb.181.2.501-507.1999.

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ABSTRACT A Staphylococcus aureus mutant (SPW3) apparently unable to survive long-term starvation was shown to have a transposon insertion within a gene homologous to ctaA ofBacillus subtilis which encodes a heme A synthase. Analysis of the cytochrome profiles of SPW3 revealed the absence of heme A-containing cytochromes compared to the parental 8325-4 strain. SPW3 demonstrated a 100-fold reduction in the ability to survive starvation induced by glucose limitation, under aerated conditions, compared to 8325-4. Analysis of starved cultures revealed that greater than 90% of the cells which demons

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AOKI, Rie, Atsushi NAGAYA, Shizuka ARAKAWA, Chiaki KATO, and Hideyuki TAMEGAI. "Identification and Diversity of Putative Aminoglycoside-Biosynthetic Aminotransferase Genes from Deep-Sea Environmental DNA." Bioscience, Biotechnology, and Biochemistry 72, no. 5 (2008): 1388–93. http://dx.doi.org/10.1271/bbb.80033.

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40

Park, Sung Ryeol, Je Won Park, Yeon Hee Ban, Jae Kyung Sohng, and Yeo Joon Yoon. "2-Deoxystreptamine-containing aminoglycoside antibiotics: Recent advances in the characterization and manipulation of their biosynthetic pathways." Nat. Prod. Rep. 30, no. 1 (2013): 11–20. http://dx.doi.org/10.1039/c2np20092a.

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Ohnishi, Yasuo, Jun Ishikawa, Hirofumi Hara, et al. "Genome Sequence of the Streptomycin-Producing Microorganism Streptomyces griseus IFO 13350." Journal of Bacteriology 190, no. 11 (2008): 4050–60. http://dx.doi.org/10.1128/jb.00204-08.

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ABSTRACT We determined the complete genome sequence of Streptomyces griseus IFO 13350, a soil bacterium producing an antituberculosis agent, streptomycin, which is the first aminoglycoside antibiotic, discovered more than 60 years ago. The linear chromosome consists of 8,545,929 base pairs (bp), with an average G+C content of 72.2%, predicting 7,138 open reading frames, six rRNA operons (16S-23S-5S), and 66 tRNA genes. It contains extremely long terminal inverted repeats (TIRs) of 132,910 bp each. The telomere's nucleotide sequence and secondary structure, consisting of several palindromes wit

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TAMEGAI, Hideyuki, To-ichiro KUKI, Yuri UDAGAWA, Rie AOKI, Atsushi NAGAYA, and Shu-ichi TSUKADA. "Exploration of Genes That Encode a Carbocycle-Forming Enzyme Involved in Biosynthesis of Aminoglycoside Antibiotics from the Environmental DNA." Bioscience, Biotechnology, and Biochemistry 70, no. 7 (2006): 1711–16. http://dx.doi.org/10.1271/bbb.60045.

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McCusker, J. H., and J. E. Haber. "crl mutants of Saccharomyces cerevisiae resemble both mutants affecting general control of amino acid biosynthesis and omnipotent translational suppressor mutants." Genetics 119, no. 2 (1988): 317–27. http://dx.doi.org/10.1093/genetics/119.2.317.

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Abstract Cyocloheximide resistant lethal (crl) mutants of Saccharomyces cerevisiae, defining 22 unlinked complementation groups, are unable to grow at 37 degrees. They are also highly pleiotropic at their permissive temperature of 25 degrees. The mutants are all unable to arrest at the G1 stage of the cell cycle when grown to stationary phase or when starved for a single amino acid, though they do arrest at G1 when deprived of all nitrogen. The crl mutants are also hypersensitive to various amino acid analogs and to 3-aminotriazole. These mutants also "tighten" leaky auxotrophic mutations that

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TAMEGAI, Hideyuki, Hiroshi SAWADA, Eriko NANGO, et al. "Roles of a 20 kDa Protein Associated with a Carbocycle-Forming Enzyme Involved in Aminoglycoside Biosynthesis in Primary and Secondary Metabolism." Bioscience, Biotechnology, and Biochemistry 74, no. 6 (2010): 1215–19. http://dx.doi.org/10.1271/bbb.90961.

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Barrow, W. W., E. L. Wright, K. S. Goh, and N. Rastogi. "Activities of fluoroquinolone, macrolide, and aminoglycoside drugs combined with inhibitors of glycosylation and fatty acid and peptide biosynthesis against Mycobacterium avium." Antimicrobial Agents and Chemotherapy 37, no. 4 (1993): 652–61. http://dx.doi.org/10.1128/aac.37.4.652.

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Li, Ruilian, Xianghua Yuan, Jinhua Wei, et al. "Synthesis and Evaluation of a Chitosan Oligosaccharide-Streptomycin Conjugate against Pseudomonas aeruginosa Biofilms." Marine Drugs 17, no. 1 (2019): 43. http://dx.doi.org/10.3390/md17010043.

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Microbial biofilms are considerably more resistant to antibiotics than planktonic cells. It has been reported that chitosan coupling with the aminoglycoside antibiotic streptomycin dramatically disrupted biofilms of several Gram-positive bacteria. This finding suggested the application of the covalent conjugate of antimicrobial natural polysaccharides and antibiotics on anti-infection therapy. However, the underlying molecular mechanism of the chitosan-streptomycin conjugate (CS-Strep) remains unclear and the poor water-solubility of the conjugate might restrict its applications for anti-infec

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Kudo, Fumitaka, Ayaka Mori, Mai Koide, et al. "One-pot enzymatic synthesis of 2-deoxy-scyllo-inosose from d-glucose and polyphosphate." Bioscience, Biotechnology, and Biochemistry 85, no. 1 (2021): 108–14. http://dx.doi.org/10.1093/bbb/zbaa025.

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Abstract 2-Deoxy-scyllo-inosose (2DOI, [2S,3R,4S,5R]-2,3,4,5-tetrahydroxycyclohexan-1-one) is a biosynthetic intermediate of 2-deoxystreptamine-containing aminoglycoside antibiotics, including butirosin, kanamycin, and neomycin. In producer microorganisms, 2DOI is constructed from d-glucose 6-phosphate (G6P) by 2-deoxy-scyllo-inosose synthase (DOIS) with the oxidized form of nicotinamide adenine dinucleotide (NAD+). 2DOI is also known as a sustainable biomaterial for production of aromatic compounds and a chiral cyclohexane synthon. In this study, a one-pot enzymatic synthesis of 2DOI from d-g

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Marmont, Lindsey S., Jacquelyn D. Rich, John C. Whitney, et al. "Oligomeric lipoprotein PelC guides Pel polysaccharide export across the outer membrane ofPseudomonas aeruginosa." Proceedings of the National Academy of Sciences 114, no. 11 (2017): 2892–97. http://dx.doi.org/10.1073/pnas.1613606114.

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Secreted polysaccharides are important functional and structural components of bacterial biofilms. The opportunistic pathogenPseudomonas aeruginosaproduces the cationic exopolysaccharide Pel, which protects bacteria from aminoglycoside antibiotics and contributes to biofilm architecture through ionic interactions with extracellular DNA. A bioinformatics analysis of genome databases suggests that gene clusters for Pel biosynthesis are present in >125 bacterial species, yet little is known about how this biofilm exopolysaccharide is synthesized and exported from the cell. In this work, we cha

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Nango, Eriko, Takashi Kumasaka, Takao Sato, Nobuo Tanaka, Katsumi Kakinuma, and Tadashi Eguchi. "Crystallization and X-ray analysis of 2-deoxy-scyllo-inosose synthase, the key enzyme in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics." Acta Crystallographica Section F Structural Biology and Crystallization Communications 61, no. 7 (2005): 709–11. http://dx.doi.org/10.1107/s1744309105018841.

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Lindley, Helen K., V. Jayne Deeble, Ursula Peschke, Mary O'Neill, Simon Baumberg, and Jonathan Cove. "Dependence on reporter gene of apparent activity in gene fusions of a Streptomyces griseus streptomycin biosynthesis promoter." Canadian Journal of Microbiology 41, no. 4-5 (1995): 407–17. http://dx.doi.org/10.1139/m95-054.

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The adjacent genes strR–strA–strB1 lie within the large cluster of genes of streptomycin biosynthesis and resistance in Streptomyces griseus. sirR encodes a pathway-specific activator StrR, suggested by previous work to be either an antiterminator or a conventional activator, binding to its DNA target via a helix-turn-helix motif. strB1 is transcribed in an StrR-dependent fashion from a promoter (PstrB1) that lies downstream from strA; between PstrB1 and sirB1 there is a 300-bp leader region containing numerous inverted repeats that could represent modulatable transcription termination sites.

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