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Journal articles on the topic 'Aminoglycosides Drug resistance in microorganisms'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Petca, Răzvan-Cosmin, Silvius Negoiță, Cristian Mareș, Aida Petca, Răzvan-Ionuț Popescu, and Călin Bogdan Chibelean. "Heterogeneity of Antibiotics Multidrug-Resistance Profile of Uropathogens in Romanian Population." Antibiotics 10, no. 5 (2021): 523. http://dx.doi.org/10.3390/antibiotics10050523.

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Urinary tract infections (UTIs) are a leading cause of morbidity for both males and females. The overconsumption of antibiotics in general medicine, veterinary, or agriculture has led to a spike in drug-resistant microorganisms; obtaining standardized results is imposed by standard definitions for various categories of drug-resistant bacteria—such as multiple-drug resistant (MDR), extensive drug-resistant (XDR), and pan drug-resistant (PDR). This retrospective study conducted in three university teaching hospitals in Romania has analyzed urine probes from 15,231 patients, of which 698 (4.58%)

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Немченко, Ulyana Nemchenko, Григорова, et al. "analysis of phago- and antibiotic sensitivity of Enterobacteriaceae bacteria isolated from women of reproductive age." Бюллетень Восточно-Сибирского научного центра Сибирского отделения Российской академии медицинских наук 1, no. 5 (2016): 150–54. http://dx.doi.org/10.12737/23414.

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Pelvic inflammatory diseases occupy a special place in the structure of general morbidity, and are polymicrobial in nature with dominance of opportunistic microorganisms, in particular bacteria of the family Enterobacteriaceae.The aim was to study the composition of the vaginal microbiota in women of reproductive age with pelvic inflammatory diseases, as well as to determine the sensitivity of isolated microorganisms to antibiotics and bacteriophages.The study included 70women of reproductive age, among them 37were diagnosed with colpitis and cervicitis, 33women in the comparison group (women

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CHARTERIS, WILLIAM P., PHILLIP M. KELLY, LORENZO MORELLI, and J. KEVIN COLLINS. "Effect of Conjugated Bile Salts on Antibiotic Susceptibility of Bile Salt–Tolerant Lactobacillus and Bifidobacterium Isolates." Journal of Food Protection 63, no. 10 (2000): 1369–76. http://dx.doi.org/10.4315/0362-028x-63.10.1369.

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Virtually every antibiotic may cause in vivo alterations in the number, level, and composition of the indigenous microbiotae. The degree to which the microbiotae are disturbed depends on many factors. Although bile may augment antibiotic activity, studies on the effect of bile on the antibiotic susceptibility of indigenous and exogenous probiotic microorganisms are lacking. It was against this background that the antibiotic susceptibility of 37 bile salt–tolerant Lactobacillus and 11 Bifidobacterium isolates from human and other sources was determined in the presence of 0.5% wt/wt oxgall (conj

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Souza, Teógenes, Maria Morais-Braga, José Costa, Antônio Saraiva, and Henrique Coutinho. "Enhancement of antimicrobial activity of antibiotics and antifungals by the use of natural products from Pityrogramma calomelanos (L.) link." Archives of Biological Sciences 64, no. 1 (2012): 43–48. http://dx.doi.org/10.2298/abs1201043s.

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The ethanol extract and methanol fraction of Pityrogramma calomelanos (L.) link were evaluated for antibacterial, antifungal and modulatory activities against strains of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans, C. krusei and C. tropicalis. The antimicrobial activity of the natural products was evaluated by the microdilution method associated or not with aminoglycosides and antifungals. The ethanol extract and methanol fraction of P. calomelanos showed good activity against S. aureus when associated with aminoglycosides and with benzoilmetronidazol agai

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Golovko, A. M., N. G. Pinchuk, T. I. Fotina, and Zh E. Klishchova. "Determination of bactericidal properties of the drug “Saroflox” in relation to museum test cultures of microorganisms." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 21, no. 95 (2019): 89–92. http://dx.doi.org/10.32718/nvlvet9516.

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Everyone knows that test cultures are used to control and quality the growth properties of nutrient media, to check the activity of antiseptics and disinfectants, as well as to assess the adequacy of the sensitivity of the tested microorganisms to new antibacterial drugs, which are currently produced by rapid temp. with the development of antibiotic resistance of microorganisms to most of the active substances used in new drugs. Moreover, it is the understanding that most antibiotics are clinically useless in treating infectious diseases because of their long-term use for chemotherapy purposes

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García-Méndez, Jorge, Erika M. Carrillo-Casas, Andrea Rangel-Cordero, et al. "Nocardia transvalensisDisseminated Infection in an Immunocompromised Patient with Idiopathic Thrombocytopenic Purpura." Case Reports in Infectious Diseases 2016 (2016): 1–3. http://dx.doi.org/10.1155/2016/3818969.

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Nocardia transvalensiscomplex includes a wide range of microorganisms with specific antimicrobial resistance patterns. N. transvalensisis an unusualNocardiaspecies. However, it must be differentiated due to its natural resistance to aminoglycosides while otherNocardiaspecies are susceptible. The present report describes aNocardiaspecies involved in an uncommon clinical case of a patient with idiopathic thrombocytopenic purpura and pulmonary nocardiosis. Microbiological and molecular techniques based on the sequencing of the 16S rRNA gene allowed diagnosis ofNocardia transvalensissensu stricto.

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V. A., Mochonyi, Savchenko O. A., Podsevakhina S. L., and Tkachenko O. V. "PROBLEMS OF THE TREATMENT OF PNEUMONIA CAUSED BY PSEUDOMONAS AERUGINOSA." Modern medical technologies 42, no. 3 (2019): 78–83. http://dx.doi.org/10.34287/mmt.3(42).2019.15.

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Pseudomonas infection is one of the most problematic pathogens of pneumonia, because it has natural resistance to many antibiotics, is able to quickly form acquired resistance, often causes severe pneumonia with a poor prognosis. Analysis of the literature data showed that today P. Aeruginosa demonstrates resistance to all anti-pest control antibiotics, with the exception of polymyxin. The levels of resistance of P.Aeruginosa are very considerably depending on the region of the survey and the profile of the hospital, which requires monitoring the sensitivity of microorganisms in each departmen

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Pkhakadze, Tamara Yakovlevna, G. G. Okropiridze, E. S. Malysheva, T. Ya Pkhakadze, G. G. Okropiridze, and E. S. Malysheva. "Choice of Antibacterial Agents for Prevention and Treatment of Infectious Complications in Traumatologic and Orthopaedic Patients by Microbiologic Monitoring." N.N. Priorov Journal of Traumatology and Orthopedics 16, no. 4 (2009): 73–78. http://dx.doi.org/10.17816/vto200916473-78.

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Etiologic structure of infectious complications in traumatologic and orthopaedic patients has been studied at CITO named after N.N. Priorov during the period from 2005 to 2007. Using modern agents and techniques 6799 samples from 3023 patients were studied. Resistance of pathogenic microorganisms to the wide spectrum of antibiotics including the drugs of last gene-ration was studied. Basing on the study results the protocols for the application of modern antibiotics including protected aminopeptides, cephalosporins of third-forth generation including the protected ones, glycopeptides, oxazolid

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Ahsan, ASM Areef, Lovely Barai, Mohammad Omar Faruq, et al. "Antibiotic Resistance Pattern among Bacteria causing Ventilator Associated Pneumonia in An Intensive Care Unit of Bangladesh." Bangladesh Critical Care Journal 4, no. 2 (2016): 69–73. http://dx.doi.org/10.3329/bccj.v4i2.30019.

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Background : Ventilator-associated pneumonia (VAP) is the most common type of nosocomial infection in critical care practice with high morbidity and mortality. Microorganisms responsible for VAP vary from place to place. So, identification of causative organism and knowledge of their resistance pattern is very important for empirical choice of antibiotic in managing VAP. The aim of this survey was to evaluate the quantitative cultures of endotracheal aspirates to determine the microorganisms responsible for VAP and to study their antibiotic resistance pattern.Materials and Methods: This cross

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AL-Khikani, Falah Hasan. "Antimicrobial Resistance Profile Among Major Bacterial Pathogens in Southern Babil, Iraq." Galician Medical Journal 27, no. 3 (2020): E202036. http://dx.doi.org/10.21802/gmj.2020.3.6.

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Background: At present, drug-resistant pathogens are considered one of the major increasing causes of morbidity and mortality around the world. The data on microorganisms' resistance assist define the best available treatment for patients. Therefore, this study aimed to screen the antimicrobial-resistant profile of different drugs in major clinical pathogens of urine, ear and wound infections. Methods: This study was conducted in Al-Shomali General Hospital, Southern Babil, Iraq from October 2019 to May 2020. Totally 67 clinical specimens obtained from the wound, urine, and ear discharge

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Barriuso, Jorge Bárcena, Deivid Roni Ribeiro, Javier Felipe Burchard, et al. "Characterization and in vitro susceptibility profile of bacterial samples harvest from canine chronic otitis." Medicina Veterinária (UFRPE) 15, no. 2 (2021): 110–18. http://dx.doi.org/10.26605/medvet-v15n2-4396.

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This study aimed to identify which are the most frequent bacteria evolved in cases of chronic otitis in dogs in the metropolitan region of Curitiba, as well to determine their in vitro antimicrobial susceptibility. Data of positive bacterial culture from dogs affected by chronic or recurrent otitis were compiled from the records of the veterinary hospital of Pontifícia Universidade Católica do Paraná, Curitiba, southern Brazil. In a period of 16 months, a total of 83 bacterial cultures were performed, resulting in 192 isolates. All isolates were submitted to antimicrobial susceptibility tests,

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Gajbhiye, Varsha P., and Lamture Y. R. "Drug utilization pattern of antimicrobials use in upper respiratory tract infection in paediatric patient of rural tertiary care hospital." International Journal of Basic & Clinical Pharmacology 8, no. 1 (2018): 74. http://dx.doi.org/10.18203/2319-2003.ijbcp20185161.

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Background: Antimicrobial agents (AMAs) are most commonly prescribed drugs for lower respiratory tract infection (LRTI). This study was conducted to evaluate pattern of prescription and AMAs use in paediatric patient for LRTI in wards of rural tertiary care teaching hospital.Methods: This is prospective, observational study undertaken in paediatric patient in tertiary care hospital. Prescriptions of 60 patient of age group 1-12years diagnosed with LRTI admitted in paediatric ward of rural tertiary care teaching hospital were studied. Positive blood sample were studied for common microorganisms

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Mitache, Mihaela Magdalena, Otilia Banu, Elvira Borcan, et al. "Resistance and Virulence Patterns in Gram Negative and Gram Positives Rods Isolated from the Hospital Environment in Bucharest, Romania." Revista de Chimie 69, no. 11 (2018): 3126–32. http://dx.doi.org/10.37358/rc.18.11.6697.

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We aimed to investigate the antibiotic resistance�and virulence�markers in�Gram negative bacilli (GNB) and Gram positives coccus (GPC), strains recently isolated from the�hospital environment and from patients with surgical wound infections in order to obtain epidemiologically relevant data.The strains identification was performed with�the automated miniApi system. The resistance�phenotypes were established�using disk diffusion (CLSI, 2017). 61 strains were screened for the production of enzymatic soluble virulence factors: hemolysins, amylase, caseinase, aesculin hydrolysis, DNA-ase, lipase,

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Kotsyuba, K. R., O. S. Voronkova, A. І. Vіnnіkov та T. M. Shevchenko. "Механізми стійкості до антибіотиків представників родини Enterobacteriaceae". Visnyk of Dnipropetrovsk University. Biology, medicine 5, № 1 (2014): 33–38. http://dx.doi.org/10.15421/021407.

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The paper deals with the basic medical scheme of antibiotics use for treatment of lesions caused by enterobacteria and mechanisms of resistance of Enterobacteriaceae to different classes of antibiotics. It is known that the main mechanisms of resistance to antibiotics are enzymatic inactivation, modification of the target, efflux, violation of conduct through the membrane and formation of metabolic shunt. The most common cases of resistance to beta-lactams among Enterobacteriaceae relate to production of plasmid and chromosomal beta-lactamases, violation of the permeability of the outer membra

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Nazarchuk, O. A., A. I. Starodub, O. V. Rymsha, V. A. Starodub, and S. A. Kolodii. "Characteristics of the etiological structure and susceptibility to antibiotics, antiseptics of infectious pathogens of respiratory organs in children in critical states." Reports of Vinnytsia National Medical University 22, no. 2 (2018): 311–17. http://dx.doi.org/10.31393/reports-vnmedical-2018-22(2)-16.

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The study of the etiological structure, the properties of pathogens of the respiratory infectious diseases in children and their resistance to antibacterial agents is particularly relevant in modern conditions, expands the search for new approaches to combating pathogens, improves the results of treatment and reduces the mortality of this pathology. The aim — study of etiological structure, sensitivity to antibiotics and antiseptics of pathogens of infectious and inflammatory diseases of respiratory organs in children. In the study there were enrolled 247 patients who were treated in Vinnytsia

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Shipitsyna, I. V., E. V. Osipova, O. A. Astashova, and D. S. Leonchuk. "Monitoring of the leading causative agents of osteomyelitis and their antibiotic resistance." Russian Clinical Laboratory Diagnostics 65, no. 9 (2020): 562–66. http://dx.doi.org/10.18821/0869-2084-2020-65-9-562-566.

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The annual monitoring of the species composition of the causative agents of osteomyelitis, the identification of antibiotic-resistant strains, the study of the species composition of associations of microorganisms, their adhesive activity will prevent the spread of infection. Analyze the spectrum of the leading causative agents of osteomyelitis, their antibiotic sensitivity, and also the adhesive activity of the identified bacterial associations. A microbiological analysis of 2197 smears of adult patients with various etiological forms of osteomyelitis who were treated in the departments of th

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Kotov, S. V., S. A. Pulbere, S. V. Belomyttsev, R. A. Perov, N. V. Alesina, and E. A. Zheltikova. "Antibiotic resistance – a new challenge of modern urology." Experimental and Сlinical Urology 13, no. 5 (2020): 113–19. http://dx.doi.org/10.29188/2222-8543-2020-13-5-113-119.

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Introduction. Analyze of the incidence and resistance to antibacterial drugs to microorganisms isolated in urine cultures of patients with urinary tract infections (UTI) from 2012 to 2019. Materials and methods. In the clinic of urology clinical hospital № 1 named after N.I. Pirogov and in the city clinical hospital № 29 named after N.E. Bauman was analyzed the results of 6083 urine cultures in 5027 patients. The traditional standardized inoculation was carried out with a 10 μl loop on the following nutrient media: agar with the addition of 5% sheep blood (Pronadisa, Spain), Levin agar (Pronad

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Kyriakidis, Ioannis, Eleni Vasileiou, Zoi Dorothea Pana, and Athanasios Tragiannidis. "Acinetobacter baumannii Antibiotic Resistance Mechanisms." Pathogens 10, no. 3 (2021): 373. http://dx.doi.org/10.3390/pathogens10030373.

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Acinetobacter baumannii is a Gram-negative ESKAPE microorganism that poses a threat to public health by causing severe and invasive (mostly nosocomial) infections linked with high mortality rates. During the last years, this pathogen displayed multidrug resistance (MDR), mainly due to extensive antibiotic abuse and poor stewardship. MDR isolates are associated with medical history of long hospitalization stays, presence of catheters, and mechanical ventilation, while immunocompromised and severely ill hosts predispose to invasive infections. Next-generation sequencing techniques have revolutio

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Srivastava, Parul, Yogesh B. Khandokar, and Jade K. Forwood. "Purification, crystallization and preliminary X-ray diffraction analysis of theN-acetyltransferase SAV0826 fromStaphylococcus aureus." Acta Crystallographica Section F Structural Biology Communications 70, no. 2 (2014): 211–14. http://dx.doi.org/10.1107/s2053230x13034493.

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Staphylococcus aureusis a prevalent microorganism that is capable of causing a wide range of infections and diseases. Several strains of this bacterial species have developed antibiotic resistance to methicillin and vancomycin, and higher death rates are still being reported each year owing to multidrug-resistant strains. Certain GCN5-relatedN-acetyltransferases (GNATs) exhibit a broad substrate range, including aminoglycosides, histones, other proteins and serotonin, and have been implicated in antibiotic drug resistance. Here, the expression, purification, crystallization and preliminary X-r

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Salipante, Stephen J., Miriam Barlow, and Barry G. Hall. "GeneHunter, a Transposon Tool for Identification and Isolation of Cryptic Antibiotic Resistance Genes." Antimicrobial Agents and Chemotherapy 47, no. 12 (2003): 3840–45. http://dx.doi.org/10.1128/aac.47.12.3840-3845.2003.

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ABSTRACT GeneHunter is a transposon tool designed for the experimental activation and identification of silent antibiotic resistance genes. The method permits the identification of novel resistance genes that lack previously identified homologues. Using Salmonella enterica serovar Typhimurium strain LT2 as a test organism for the in vivo version of the GeneHunter method, we were able to activate, clone, and identify two cryptic antibiotic resistance genes, the aminoglycoside acetyltransferase aac(6′)-Iaa and the probable Mar-A regulon activator rma. Because the method requires being able to el

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Pise, Nitin D., and Swapnil B. Kaikade. "Analysis of prescribing pattern of antimicrobial agents and its rationality in tertiary care rural setup of Central India." International Journal of Basic & Clinical Pharmacology 6, no. 9 (2017): 2289. http://dx.doi.org/10.18203/2319-2003.ijbcp20173761.

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Background: Antimicrobial agents are most commonly prescribed drug and share major cost of the treatment. Excessive and inappropriate use of antimicrobial has become a global problem, resulting not only in substantial economic burden on healthcare system but also in contributing to the selective pressure favoring the emergence of antibiotic-resistant microorganisms. Antimicrobial agents which one uses for prophylactic, empiric and therapeutic purposes, depends upon the local epidemiology of infectious diseases, microbiology and resistance pattern as well as local clinical experience. Rational

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Khodabandeh, Mahmoud, Mohsen Mohammadi, Mohammad Reza Abdolsalehi, et al. "High-Level Aminoglycoside Resistance in Enterococcus Faecalis and Enterococcus Faecium; as a Serious Threat in Hospitals." Infectious Disorders - Drug Targets 20, no. 2 (2020): 223–28. http://dx.doi.org/10.2174/1871526519666181130095954.

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Aims and Objectives: The present work aimed to evaluate the frequency of aminoglycoside- modifying enzymes encoding genes in the E. faecalis and E. faecium and their antibiotic resistance profile. Methods: A total of 305 different clinical samples were subjected for identification and antibiotic susceptibility test. The high-level aminoglycoside resistance was identified by MIC and Kirby Bauer disc diffusion method. The prevalence of aac (6')-Ie-aph (2'')-Ia, aph (3')-IIIa and ant (4')- Ia genes was determined by multiplex- PCR. In total, 100 enterococci strains were isolated. The prevalence o

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Junior, Adelino Freire, Fernando Fagundes, Mozar Castro Neto, Carine Barbosa, and Thais Alves. "Evaluation of Initial Outcomes of an Antimicrobial Stewardship Program in a Nonprofit Hospital in Brazil." Infection Control & Hospital Epidemiology 41, S1 (2020): s228—s229. http://dx.doi.org/10.1017/ice.2020.775.

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Background: One of the main global public health challenges is the fight against microbial resistance, according to the World Health Organization. Inadequate use of antimicrobials is considered one of the main factors related to the phenomenon and is quite common in the hospital environment. Managing the use of antimicrobials in hospitals has become a necessity and has shown positive results in many ways, such as maximizing the effects of pharmacotherapy, preventing the emergence of resistant microorganisms, and reducing healthcare costs. Methods: The prescriptions for patients admitted to a 3

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Kryukov, E., Shamil' Gizatullin, Daniil Korabelnikov, Marat Ziyatdinov, Anastasia Sidorova, and Ekaterina Kolobaeva. "The main pathogens of healthcare-associated infections in patients of neurosurgery intensive care unit and antimicrobial activity of the most used antibacterial drugs." Russian Medical and Social Journal 1, no. 2 (2019): 40–56. http://dx.doi.org/10.35571/rmsj.2019.2.004.

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Importance. Healthcare-associated infectionsare an important issue in the neurosurgery. The changes in the epidemiological structure of etiological agents, the increase of antimicrobial drug resistance may lead to the ineffectiveness of previously used patterns for the prevention and treatment of healthcare-associated infections. Objective.The aim of the research was to study the microbiological structure of leading etiological agents that cause healthcare-associated infectionsin patients of neurosurgery intensive care unitand to evaluate the effectiveness of the most used antibacterial

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Martynenko, H. A. "Analysis and forecasts of Salmonella spp. antibiotic resistance in Dnipropetrovsk region (Ukraine)." Veterinary Medicine: inter-departmental subject scientific collection, no. 105 (August 7, 2019): 16–19. http://dx.doi.org/10.36016/vm-2019-105-3.

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The paper presents data of the research aimed at studying the species composition of major pathogens circulating in the region and the resistance to antibacterial drugs in pathogens of salmonella, one of the most common zoonoses. Within the period 2014–2018 the qualitative composition of microflora from biological and pathological materials from different groups of animals was studied in Dnipropetrovsk region. Own research results and the results of the regional veterinary statistical reporting were analyzed. Within the short period of five years, 237 cultures of Gram-negative bacteria were de

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Rudenko, Pavel, Yuriy Vatnikov, Nadezhda Sachivkina, et al. "Search for Promising Strains of Probiotic Microbiota Isolated from Different Biotopes of Healthy Cats for Use in the Control of Surgical Infections." Pathogens 10, no. 6 (2021): 667. http://dx.doi.org/10.3390/pathogens10060667.

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Despite the introduction of modern methods of treatment, the creation of new generations of antibacterial agents, and the constant improvement of aseptic and antiseptic methods, the treatment of purulent–inflammatory processes remains one of the most complex and urgent problems in veterinary practice. The article presents the results of the isolation of indigenous microbiota from various biotopes of healthy cats, as well as the study of their biological marker properties for the selection of the most optimal strains in probiotic medicines for the control of surgical infections. It was demonstr

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Ahmed, Dalia, Laith Yaaqoob, and Sehand Arif. "Biosynthesis of TiO2 nanoparticles using prodigiosin and evaluating its antibacterial activity against biofilm producing MDR- Acinetobacter baumannii." Al-Anbar Journal of Veterinary Sciences 13, no. 2 (2020): 137–51. http://dx.doi.org/10.37940/ajvs.2020.13.2.13.

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A rising number of hospital infections were caused by multi drug resistant A.baumannii. This microorganism has become a big global concern for clinicians. This study aimed to evaluate the antimicrobial activity of biosynthesized TiO2 nanoparticles against biofilm producing multi drug resistant A. baumannii. Bacteria were isolated from burn wounds. The selected isolate was identified using the routine biochemical assays, viteck 2, and confirmed by PCR technique, targeting the 16S rRNA and blaOXA-51 genes. Antimicrobial susceptibility tests were performed using Viteck 2 system and the biofilm pr

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Chmielarczyk, Agnieszka, Monika Pomorska-Wesołowska, Dorota Romaniszyn, and Jadwiga Wójkowska-Mach. "Healthcare-Associated Laboratory-Confirmed Bloodstream Infections—Species Diversity and Resistance Mechanisms, a Four-Year Retrospective Laboratory-Based Study in the South of Poland." International Journal of Environmental Research and Public Health 18, no. 5 (2021): 2785. http://dx.doi.org/10.3390/ijerph18052785.

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Introduction: Regardless of the country, advancements in medical care and infection prevention and control of bloodstream infections (BSIs) are an enormous burden of modern medicine. Objectives: The aim of our study was to describe the epidemiology and drug-resistance of laboratory-confirmed BSI (LC-BSIs) among adult patients of 16 hospitals in the south of Poland. Patients and methods: Data on 4218 LC-BSIs were collected between 2016–2019. The identification of the strains was performed using MALDI-TOF. Resistance mechanisms were investigated according to European Committee on Antimicrobial S

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Horiuk, Y. V., M. D. Kukhtyn, V. V. Horiuk, and S. P. Kernychnyi. "COMPARISON OF THE EFFECT OF ANTIBIOTICS AND BACTERIOPHAGE PHAGE SAVB14 ON BIOFILMS FORMED BY STAPHYLOCOCCUS AUREUS VARIANT BOVIS." Podilian Bulletin: Agriculture, Engineering, Economics, no. 32 (June 29, 2020): 166–74. http://dx.doi.org/10.37406/2706-9052-2020-1-19.

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During the development of mastitis in cows, the formation of a biofilm pathogen is an effective way to preserve it in the microenvironment of mammary gland. Biofilm infections are difficult to treat with antimicrobials, and bacterial resistance to antibiotics increases to 1000-fold level, compared with what is observed when grown in planktonic conditions. The aim of study – to determine and compare the effect of antimicrobial drugs and bacteriophage Phage SAvB14 in the destruction of biofilms formed by S. aureus var. bovis. Isolation and species identification of staphylococci were performed a

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Giedraitienė, Agnė, Astra Vitkauskienė, Rima Naginienė, and Alvydas Pavilonis. "Antibiotic Resistance Mechanisms of Clinically Important Bacteria." Medicina 47, no. 3 (2011): 19. http://dx.doi.org/10.3390/medicina47030019.

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Bacterial resistance to antimicrobial drugs is an increasing health and economic problem. Bacteria may be innate resistant or acquire resistance to one or few classes of antimicrobial agents. Acquired resistance arises from: (i) mutations in cell genes (chromosomal mutation) leading to cross-resistance, (ii) gene transfer from one microorganism to other by plasmids (conjugation or transformation), transposons (conjugation), integrons and bacteriophages (transduction). After a bacterium gains resistance genes to protect itself from various antimicrobial agents, bacteria can use several biochemi

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Golub, N. B. "RESISTANCE TO ANTIBIOTICS AND THEIR UTILIZATION BY MICROORGANISMS." Biotechnologia Acta 14, no. 3 (2021): 22–29. http://dx.doi.org/10.15407/biotech14.03.021.

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With the development of antibiotics application, their spread in the natural environment increases dramatically. The presence of antibiotics in the environment changes microorganism and other living beings ratio and composition, which causes a negative impact on biochemical processes that take place in the environment. The spread of antibiotic resistance genes in environmental microorganisms is a growing problem of environmental safety and human health. Aim. The objective of the work was to analyze the adaptation mechanisms of microorganisms to the influence of antibiotics and methods for anti

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Stillwell, Paul C., Gregory L. Kearns, and Richard F. Jacobs. "Endotracheal Tobramycin in Gram-Negative Pneumonitis." Drug Intelligence & Clinical Pharmacy 22, no. 7-8 (1988): 577–81. http://dx.doi.org/10.1177/106002808802200713.

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This report describes the treatment of resistant gram-negative pneumonitis in a compromised host by the combined use of intravenous and endotracheal tobramycin. The endotracheal administration appeared to have an effect on the serum concentration and elimination rate, necessitating a reduction in the amount of drug given intravenously. The only apparent clinical complication of endotracheal drug administration was transient coughing. The addition of endotracheal aminoglycosides to intravenous antibiotics may be useful in pediatric patients with unresponsive (or other difficult-to-treat) pneumo

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Zembower, Teresa R., Gary A. Noskin, Michael J. Postelnick, Chieu Nguyen, and Lance R. Peterson. "The utility of aminoglycosides in an era of emerging drug resistance." International Journal of Antimicrobial Agents 10, no. 2 (1998): 95–105. http://dx.doi.org/10.1016/s0924-8579(98)00033-8.

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Avner, Benjamin S., Arsenio M. Fialho, and Ananda M. Chakrabarty. "Overcoming drug resistance in multi-drug resistant cancers and microorganisms." Bioengineered 3, no. 5 (2012): 262–70. http://dx.doi.org/10.4161/bioe.21130.

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Reeves, Analise Z., Patricia J. Campbell, Razvan Sultana, et al. "Aminoglycoside Cross-Resistance in Mycobacterium tuberculosis Due to Mutations in the 5′ Untranslated Region ofwhiB7." Antimicrobial Agents and Chemotherapy 57, no. 4 (2013): 1857–65. http://dx.doi.org/10.1128/aac.02191-12.

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ABSTRACTSince the discovery of streptomycin's bactericidal activity againstMycobacterium tuberculosis, aminoglycosides have been utilized to treat tuberculosis (TB). Today, the aminoglycosides kanamycin and amikacin are used to treat multidrug-resistant (MDR) TB, and resistance to any of the second-line injectable antibiotics, including kanamycin, amikacin, or capreomycin, is a defining characteristic of extensively drug-resistant (XDR) TB. Resistance to kanamycin and streptomycin is thought to be due to the acquisition of unlinked chromosomal mutations. However, we identified eight independen

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McCollister, Bruce D., Matthew Hoffman, Maroof Husain, and Andrés Vázquez-Torres. "Nitric Oxide Protects Bacteria from Aminoglycosides by Blocking the Energy-Dependent Phases of Drug Uptake." Antimicrobial Agents and Chemotherapy 55, no. 5 (2011): 2189–96. http://dx.doi.org/10.1128/aac.01203-10.

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ABSTRACTOur investigations have identified a mechanism by which exogenous production of nitric oxide (NO) induces resistance of Gram-positive and -negative bacteria to aminoglycosides. An NO donor was found to protectSalmonellaspp. against structurally diverse classes of aminoglycosides of the 4,6-disubstituted 2-deoxystreptamine group. Likewise, NO generated enzymatically by inducible NO synthase of gamma interferon-primed macrophages protected intracellularSalmonellaagainst the cytotoxicity of gentamicin. NO levels that elicited protection against aminoglycosides repressedSalmonellarespirato

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Morić, Ivana, Miloje Savić, Tatjana Ilić-Tomić, Sandra Vojnović, Sanja Bajkić, and Branka Vasiljević. "rRNA Methyltransferases and their Role in Resistance to Antibiotics." Journal of Medical Biochemistry 29, no. 3 (2010): 165–74. http://dx.doi.org/10.2478/v10011-010-0030-y.

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rRNA Methyltransferases and their Role in Resistance to AntibioticsMethyltransferases (MTases), a large protein superfamily, commonly use S-adenosyl-L-methionine (SAM) as the methyl group donor. SAM-dependant MTases methylate both nucleic acids (DNA, RNA) and proteins, and thus modulate their activity, function and folding. Methylation of G1405 or A1408 nucleotides of 16S rRNA in aminoglycoside-producing microorganisms confers the resistance to their own toxic product(s). This mechanism of resistance has been considered as unique to antibiotics producers until recently. Since 2003, methylation

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Demirev, Plamen A., Nathan S. Hagan, Miquel D. Antoine, Jeffrey S. Lin, and Andrew B. Feldman. "Establishing Drug Resistance in Microorganisms by Mass Spectrometry." Journal of The American Society for Mass Spectrometry 24, no. 8 (2013): 1194–201. http://dx.doi.org/10.1007/s13361-013-0609-x.

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ჩიკვილაძე დ., Chikviladze D., Gachechiladze Kh გაჩეჩილაძე ხ., Mikeladze M. მიქელაძე მ., and მეტრეველი დ. Metreveli D. "PROFILE OF COLIFORM STRAINS’ ANTIBIOTIC RESISTANCE." TSMU COLLECTION OF SCIENTIFIC WORKS 49 (November 4, 2019): 135–57. http://dx.doi.org/10.52340/csw.v49i0.208.

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 The spectrum of sensitivity of 112 E. coli strains isolated from patients with acute intestinal infection to 23 antibiotics was investigated by the agar dilution method, which revealed an increase in drug resistance and the emergence of multidrug-resistant strains (33.04%). It was found that the drug resistance of the pathogen to nalidixic acid and carbopenems increased and its high sensitivity to some ftuoroquinolones, III and IV generation aminoglycosides, penicillins and cephalosporins preserved. The drug resistance in future may lead to the formation of hospital strains among E. col

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Akshay, Subramanian, Mihai Bertea, Sven N. Hobbie, et al. "Phylogenetic Sequence Variations in Bacterial rRNA Affect Species-Specific Susceptibility to Drugs Targeting Protein Synthesis." Antimicrobial Agents and Chemotherapy 55, no. 9 (2011): 4096–102. http://dx.doi.org/10.1128/aac.01398-10.

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ABSTRACTAntibiotics targeting the bacterial ribosome typically bind to highly conserved rRNA regions with only minor phylogenetic sequence variations. It is unclear whether these sequence variations affect antibiotic susceptibility or resistance development. To address this question, we have investigated the drug binding pockets of aminoglycosides and macrolides/ketolides. The binding site of aminoglycosides is located within helix 44 of the 16S rRNA (A site); macrolides/ketolides bind to domain V of the 23S rRNA (peptidyltransferase center). We have used mutagenesis of rRNA sequences inMycoba

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Xiong, Y. Q., J. Caillon, H. Drugeon, G. Potel, and D. Baron. "Influence of pH on adaptive resistance of Pseudomonas aeruginosa to aminoglycosides and their postantibiotic effects." Antimicrobial Agents and Chemotherapy 40, no. 1 (1996): 35–39. http://dx.doi.org/10.1128/aac.40.1.35.

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Adaptive resistance to aminoglycosides in Pseudomonas aeruginosa and other gram-negative bacilli is usually induced by the initial exposure to the drug. We investigated the influence of pH on the adaptive resistance of a clinical P. aeruginosa strain to aminoglycosides in vitro and on their postantibiotic effects. For adaptive resistance, the first-exposure concentrations of both amikacin and netilmicin were one, two, four, and eight times the MIC of each drug and the second-exposure concentrations were two times the MIC of each drug. Adaptive resistance was greater and more prolonged with hig

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Coutinho, Henrique D. M., José G. M. Costa, Edeltrudes O. Lima, Vivyanne S. Falcão-Silva, and José P. Siqueira-Júnior. "In vitrointerference ofMomordica charantiain the resistance to aminoglycosides." Pharmaceutical Biology 00, no. 00 (2009): 090818050145039–4. http://dx.doi.org/10.1080/13880200902991540.

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Reena Rajan. "Mechanism of Drug Resistance in Enterococci and Therapeutic Options - A Review." International Journal of Research in Pharmaceutical Sciences 12, no. 1 (2021): 102–6. http://dx.doi.org/10.26452/ijrps.v12i1.3942.

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Enterococci exhibit an array of ways for constitutional and extrinsic resistance to primary antimicrobial agents available for clinical use. Susceptibility of these agents to β lactams, aminoglycosides or glycopeptides antibiotics or low susceptibility to combination of these agents, monomicrobial or polymicrobial nature of the infection, the involvement of heart valves or other endovascular structures affects therapy of Enterococcal infection. Vancomycin-resistant phenotypes A and B are most prevalent among medically important Enterococci isolates. Due to poor uptake of aminoglycosides, moder

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Dhamdhere, Girija, Ganesh Krishnamoorthy, and Helen I. Zgurskaya. "Interplay between Drug Efflux and Antioxidants in Escherichia coli Resistance to Antibiotics." Antimicrobial Agents and Chemotherapy 54, no. 12 (2010): 5366–68. http://dx.doi.org/10.1128/aac.00719-10.

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ABSTRACT We investigated possible cross talk between endogenous antioxidants glutathione, spermidine, and glutathionylspermidine and drug efflux in Escherichia coli. We found that cells lacking either spermidine or glutathione are less susceptible than the wild type to novobiocin and certain aminoglycosides. In contrast, exogenous glutathione protects against both bactericidal and bacteriostatic antibiotics. The glutathione protection does not require the AcrAB efflux pump but fails in cells lacking TolC because exogenous glutathione is toxic to these cells.

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Hocquet, Didier, Christelle Vogne, Farid El Garch, et al. "MexXY-OprM Efflux Pump Is Necessary for Adaptive Resistance of Pseudomonas aeruginosa to Aminoglycosides." Antimicrobial Agents and Chemotherapy 47, no. 4 (2003): 1371–75. http://dx.doi.org/10.1128/aac.47.4.1371-1375.2003.

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ABSTRACT Exposure of Pseudomonas aeruginosa to aminoglycosides frequently selects for recalcitrant subpopulations exhibiting an unstable, “adaptive” resistance to these antibiotics. In this study, we investigated the implication in the phenomenon of MexXY-OprM, an active efflux system known to export aminoglycosides in P. aeruginosa. Immunoblotting experiments demonstrated that the transporter MexY, but not the outer membrane pore OprM, was overproduced during the post-drug exposure adaptation period in wild-type strain PAO1. Furthermore, MexY production was dependent upon the degree of bacter

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Wargo, Kurt A., and Jonathan D. Edwards. "Aminoglycoside-Induced Nephrotoxicity." Journal of Pharmacy Practice 27, no. 6 (2014): 573–77. http://dx.doi.org/10.1177/0897190014546836.

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Aminoglycosides are among the oldest antibiotics available to treat serious infections caused by primarily, Gram-negative bacteria. The most commonly utilized parenteral agents in this class include gentamicin, tobramycin and amikacin. Aminoglycosides are concentration-dependent, bactericidal agents that undergo active transport into the cell where they inhibit protein synthesis on the 30S subunit of the bacterial ribosome. As the use of aminoglycosides became more widespread, the toxic effects of these agents, most notably ototoxicity and nephrotoxicity, became more apparent. When other, safe

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Jassem, Agatha N., James E. A. Zlosnik, Deborah A. Henry, Robert E. W. Hancock, Robert K. Ernst, and David P. Speert. "In VitroSusceptibility of Burkholderia vietnamiensis to Aminoglycosides." Antimicrobial Agents and Chemotherapy 55, no. 5 (2011): 2256–64. http://dx.doi.org/10.1128/aac.01434-10.

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ABSTRACTBurkholderia cepaciacomplex (BCC) bacteria are opportunistic pathogens that can cause severe disease in cystic fibrosis (CF) patients and other immunocompromised individuals and are typically multidrug resistant. Here we observed that unlike other BCC species, most environmental and clinicalBurkholderia vietnamiensisisolates were intrinsically susceptible to aminoglycosides but not to cationic antimicrobial peptides or polymyxin B. Furthermore, strains acquired aminoglycoside resistance during chronic CF infection, a phenomenon that could be induced under tobramycin or azithromycin pre

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Fong, Desiree H., and Albert M. Berghuis. "Structural Basis of APH(3′)-IIIa-Mediated Resistance to N1-Substituted Aminoglycoside Antibiotics." Antimicrobial Agents and Chemotherapy 53, no. 7 (2009): 3049–55. http://dx.doi.org/10.1128/aac.00062-09.

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ABSTRACT Butirosin is unique among the naturally occurring aminoglycosides, having a substituted amino group at position 1 (N1) of the 2-deoxystreptamine ring with an (S)-4-amino-2-hydroxybutyrate (AHB) group. While bacterial resistance to aminoglycosides can be ascribed chiefly to drug inactivation by plasmid-encoded aminoglycoside-modifying enzymes, the presence of an AHB group protects the aminoglycoside from binding to many resistance enzymes, and hence, the antibiotic retains its bactericidal properties. Consequently, several semisynthetic N1-substituted aminoglycosides, such as amikacin,

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Khurshid, Mohsin, Muhammad Hidayat Rasool, Muhammad Hussnain Siddique, et al. "Molecular mechanisms of antibiotic co-resistance among carbapenem resistant Acinetobacter baumannii." Journal of Infection in Developing Countries 13, no. 10 (2019): 899–905. http://dx.doi.org/10.3855/jidc.11410.

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Introduction: The spread of carbapenem-resistant Acinetobacter baumannii (CRAB) is difficult to control especially in the hospitals due to the successful mobilization and evolution of the genetic elements harboring the resistant determinants. The study was conducted to examine the distribution of aminoglycosides, tetracycline, and sulfonamide-resistant determinants among CRAB isolates that carry the blaOXA-23 gene. Methodology: For a total of 160 CRAB strains isolated at tertiary care hospitals of Pakistan that mainly carried blaOXA-23 gene were included in the study to evaluate the asso

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Noor, Rashed, Syeda Muntaka Maniha, Taskina Murshed, and M. Majibur Rahman. "Effectiveness of Antibiotics: Anti-Bacterial Activity or Microbial Drug Resistance?" Bangladesh Journal of Microbiology 36, no. 2 (2020): 111–14. http://dx.doi.org/10.3329/bjm.v36i2.45537.

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Antibiotics, both broad- and narrow spectrum, are widely used for treatment of specific infection by a consortium of microorganisms or by a single pathogen, respectively. Oral or intravenous, or even topical administration of different categories of antibiotics in various forms is a common practice round the globe. Yet for the recent years a major public health issue has been raised by the emergence of the drug-resistance microorganisms. A number of researches focused on the issue of the ineffectiveness of antibiotics as well as regarding the evolution of the drugresistance genes within the pa

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