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Relevant bibliographies by topics / Aminopropiophenone

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Journal articles

Academic literature on the topic 'Aminopropiophenone'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 July 2025

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Journal articles on the topic "Aminopropiophenone"

1

Marrs, T. C., R. H. Inns, J. E. Bright, and S. G. Wood. "The Formation of Methaemoglobin by 4-aminopropiophenone (PAPP) and 4-(N-hydroxy) aminopropiophenone." Human & Experimental Toxicology 10, no. 3 (1991): 183–88. http://dx.doi.org/10.1177/096032719101000306.

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Oral dosing of rats with the cyanide antidote 4-aminopropiophenone (PAPP), brought about peak methaemoglobin levels at 15-40 min, but peak levels were attained at 15-25 min after intravenous dosing. After both oral and intravenous administration at equimolar doses, 4-(N-hydroxy)aminopropiophenone (PHAPP), the putative methaemoglobin-producing metabolite of PAPP, produced higher peak levels of methaemoglobin than PAPP. Plasma from rats injected with PAPP was capable of forming methaemoglobin when added to naive rat erythrocytes. The identity of the metabolite responsible is discussed.

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2

Vera, William J., and Ajoy K. Banerjee. "First synthesis of 3-methoxy-4-aminopropiophenone." Journal of Chemical Research 36, no. 9 (2012): 543–44. http://dx.doi.org/10.3184/174751912x13418461206368.

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3

Fisher, P., and C. O'Connor. "Oral toxicity of p-aminopropiophenone to ferrets." Wildlife Research 34, no. 1 (2007): 19. http://dx.doi.org/10.1071/wr06125.

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Ferrets (Mustela furo) are pests in New Zealand and new methods are being sought for their control. The hydrochloride form of p-aminopropiophenone (PAPP) was highly toxic to ferrets when delivered by gavage, with LD50 and LD99 values of 15.52 and 20.80 mg kg–1, respectively. Signs of toxicosis progressed through pallor and cyanosis, impaired coordination, prostration with reduced responses to stimuli, with death in ~2 h. In a preliminary assessment of effective doses of PAPP in bait, 19 of 20 ferrets consumed chick carcasses containing ~46 mg PAPP within 40 min. Ferrets that ate chick baits al

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4

Bright, J. E., and T. C. Marrs. "Effect of p-aminopropiophenone (PAPP), a cyanide antidote, on cyanide given by intravenous infusion." Human Toxicology 6, no. 2 (1987): 133–37. http://dx.doi.org/10.1177/096032718700600205.

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1 Beagle bitches were infused with potassium cyanide solution after protection with p-aminopropiophenone (PAPP). 2 Methaemoglobin levels fell very rapidly after the start of the infusion. 3 Whole blood and plasma cyanide estimations revealed that most of the cyanide was sequestered inside the red cells. 4 Animals survived a supralethal dose of cyanide when protected with PAPP.

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5

Marrs, T. C., and J. E. Bright. "Kinetics of Methaemoglobin Production (1)." Human Toxicology 5, no. 5 (1986): 295–301. http://dx.doi.org/10.1177/096032718600500501.

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Methaemoglobin profiles have been studied by using ISIS, a simulation package, and NONLIN, a ion-linear least-squares analysis regression program. A simple kinetic model which satisfactorily describes methaemoglobin profiles after p-aminopropiophenone (PAPP) administration and 4-dimethylaminophenol (DMAP) administration has been developed. The two compounds differed nainly in their effective rates of elimination. The model less satisfactorily described methaemoglobin profiles after p-hydroxyaminopropiophenone (PHAPP) administration.

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6

Bright, J. E., and T. C. Marrs. "Kinetics of Methaemoglobin Production (2). Kinetics of the Cyanide Antidote p-Aminopropiophenone During Oral Administration." Human Toxicology 5, no. 5 (1986): 303–7. http://dx.doi.org/10.1177/096032718600500502.

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The kinetics of methaemoglobin production by orally administered p-aminopropiophenone (PAPP) was studied by using a kinetic model previously developed to describe methaemoglobinaemia consequent on intravenous injection of PAPP. Both ISIS, a simulation package, and NONLIN, a non-linear least-squares regression analysis program, were used to analyse the data. Some modification of the model was necessary to describe oral profiles and 40-50% of the administered PAPP appeared to be being metabolized at first pass to a non-active metabolite.

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7

Bright, J. E., A. C. Woodman, T. C. Marrs, and S. G. Wood. "Sex differences in the production of methaemoglobinaemia by 4-aminopropiophenone." Xenobiotica 17, no. 1 (1987): 79–83. http://dx.doi.org/10.3109/00498258709047177.

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8

Baskin, Steven I., and Robert F. Fricke. "The Pharmacology of p-Aminopropiophenone in the Detoxification of Cyanide." Cardiovascular Drug Reviews 10, no. 3 (1992): 358–75. http://dx.doi.org/10.1111/j.1527-3466.1992.tb00256.x.

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9

Fisher, Penny M., Cheryl E. O'Connor, and Elaine C. Murphy. "Acute oral toxicity of p‐aminopropiophenone to stoats (Mustela erminea)." New Zealand Journal of Zoology 32, no. 3 (2005): 163–69. http://dx.doi.org/10.1080/03014223.2005.9518409.

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10

KONTANI, Hitoshi, Akihiro MANO, Ryozo KOSHIURA, et al. "Central muscle relaxant activities of 2-methyl-3-aminopropiophenone derivatives." Folia Pharmacologica Japonica 89, no. 2 (1987): 91–101. http://dx.doi.org/10.1254/fpj.89.91.

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