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Journal articles on the topic 'Amlodipine and hydrochlorothiazide'

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Published: 2 June 2025
Last updated: 31 July 2025

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1

Nagaraju, Pappula, Jyothi Koppula, and Ayesha Ameen Shaik. "Development and Validation of Novel RP-HPLC Method for the Simultaneous Estimation of Amlodipine and Hydrochlorothiazide in Combined Dosage Form." International Journal of Science and Healthcare Research 4, no. 3 (2019): 160–65. https://doi.org/10.5281/zenodo.3935426.

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A simple, specific, accurate, rapid, inexpensive Reversed Phase High Performance liquid chromatographic method has been developed and validated for the simultaneous determination of Amlodipine and Hydrochlorothiazide in pharmaceutical tablet dosage form. Separation was achieved using a C18 column with mobile phase consisting of Phosphate Buffer (pH 3.4) and Methanol (55:45 v/v) in isocratic mode at 1 ml/min flow rate. Column effluent was monitored at 238 nm using a UV detector. The retention time for Amlodipine and Hydrochlorothiazide was found to be 2.7 and 3.4 min respectively the method was
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Deeks, Emma D. "Amlodipine/Valsartan/Hydrochlorothiazide." American Journal Cardiovascular Drugs 9, no. 6 (2009): 411–18. http://dx.doi.org/10.2165/11204350-000000000-00000.

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Jeon, So-Yeon, Ji-Hyeon Jeon, Jin-Hyang Park, et al. "Simultaneous Analysis of a Combination of Anti-Hypertensive Drugs, Fimasartan, Amlodipine, and Hydrochlorothiazide, in Rats Using LC-MS/MS and Subsequent Application to Pharmacokinetic Drug Interaction with Red Ginseng Extract." Toxics 10, no. 10 (2022): 576. http://dx.doi.org/10.3390/toxics10100576.

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Fimasartan, amlodipine, and hydrochlorothiazide are commonly used in combination therapies as antihypertensive drugs. This study aimed to develop and validate an analytical method for fimasartan, its active and major metabolite fimasartan-amide, amlodipine, and hydrochlorothiazide in rat plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The standard calibration curves for fimasartan (1–500 ng/mL), its active and major metabolite fimasartan-amide (0.3–100 ng/mL), amlodipine (0.5–200 ng/mL), and hydrochlorothiazide (5–5000 ng/mL) were linear with R2 > 0.9964, and the int
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Saminathan, J., and T. Vetrichelvan. "UV SPECTROPHOTOMETRIC ABSORPTION CORRECTION METHOD FOR SIMULTANEOUS ESTIMATION OF OLMESA RTAN MEDOXOMIL, AMLODIPINE BESYLATE AND HYDROCHLOROTHIAZIDE IN COMBINED TABLET DOSAGE FORM." INDIAN DRUGS 54, no. 07 (2017): 40–45. http://dx.doi.org/10.53879/id.54.07.10761.

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A simple, accurate, precise, economical and validated uv spectrometric absorption correction method was developed for olmesartan, medoxomil amlodipine besylate and hydrochlorothiazide in bulk and its dosage form. The stock solutions were prepared in methanol followed by further dilutions with double distilled water. The λmax for olmesartan, amlodipine besylate and hydrochlorothiazide were 256.5 nm, 362 nm and 316 nm, respectively. Beer’s law was obeyed in the concentration range of 3-18 μg/mL, 1- 6μg/mL and 2-12 μg/mL, respectively. The method was validated by following the analytical performa
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5

Deeks, Emma D. "Olmesartan Medoxomil/Amlodipine/Hydrochlorothiazide." Drugs 71, no. 2 (2011): 209–20. http://dx.doi.org/10.2165/11206770-000000000-00000.

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6

Thi Thu Nguyen, Hien, Tho Van Duong, and Dung Thanh Phan. "Development and validation of HPLC method for simultaneous determination of amlodipine besylat, telmisartan and hydrochlorothiazide in combined tablets." MedPharmRes 7, no. 4 (2023): 67–74. http://dx.doi.org/10.32895/ump.mpr.7.4.8.

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Introduction: A combination of three active ingredients amlodipine besylate, telmisartan, and hydrochlorothiazide has been used and proven effective in the treatment of hypertension in patients with moderate to severe hypertension, while it contributes to a reduction in product costs and increases patient compliance. However, there are no monographs in pharmacopoeias for the simultaneous quantification of these three active ingredients. Therefore, in order to contribute to the establishment of an in-house specification for domestic generic drugs, shorten the time of quantifying each ingredient
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Fadhilla, Salma Nara, and Dharma Permana. "The use of antihypertensive drugs in the treatment of essential hypertension at outpatient installations, Puskesmas Karang Rejo, Tarakan." Yarsi Journal of Pharmacology 1, no. 1 (2020): 7–14. http://dx.doi.org/10.33476/yjp.v1i1.1209.

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Background: Essential hypertension is the most common type of hypertension, affecting 95% of hypertensive patients. Essential hypertension can be managed through a combination lifestyle changes and antihypertensive drugs. The aim of this study was to know the use of antihypertensive drugs in the treatment of essential hypertensive at outpatient installations, Puskesmas Karang Rejo, Tarakan.Methods: The research method is descriptive by using secondary data from complete patient medical records of the essential hypertension patients undergoing outpatient treatment at Puskesmas Karang Rejo, Tara
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Vischer, Annina S., Gabriela M. Kuster, Raphael Twerenbold, et al. "Influence of Antihypertensive Treatment on RAAS Peptides in Newly Diagnosed Hypertensive Patients." Cells 10, no. 3 (2021): 534. http://dx.doi.org/10.3390/cells10030534.

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(1) Background: Recently, influences of antihypertensive treatment on the renin–angiotensin–aldosterone system (RAAS) has gained attention, regarding a possible influence on inflammatory and anti-inflammatory pathways. We aimed to study the effects of newly initiated antihypertensive drugs on angiotensin (Ang) II and Ang (1–7) as representers of two counter-regulatory axes. (2) Methods: In this randomized, open-label trial investigating RAAS peptides after the initiation of perindopril, olmesartan, amlodipine, or hydrochlorothiazide, Ang II and Ang (1–7) equilibrium concentrations were measure
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Huang, Qi FANG, Di Zhang, Yihong Luo, et al. "COMPARISON OF TWO SINGLE-PILL DUAL COMBINATION ANTIHYPERTENSIVE THERAPIES IN CHINESE PATIENTS." Journal of Hypertension 42, Suppl 1 (2024): e115-e116. http://dx.doi.org/10.1097/01.hjh.0001020472.97256.69.

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Objective: Current hypertension guidelines recommend combination of an angiotensin-converting enzyme inhibitor or angiotensin-receptor blocker with a calcium-channel blocker or thiazide diuretic as initial antihypertensive therapy in patients with monotherapy uncontrolled hypertension. However, to what extent these two different combinations are comparable in blood pressure (BP) lowering efficacy and safety remains under investigation, especially in the Chinese population. We investigated the BP lowering efficacy and safety of the amlodipine/benazepril and benazepril/hydrochlorothiazide dual t
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Lee, I.-Te, Wayne Huey-Herng Sheu, Yi-Jen Hung, Jung-Fu Chen, Chih-Yuan Wang, and Wen-Jane Lee. "Assessment of Glomerular Filtration Rate Based on Alterations of Serum Brain-Derived Neurotrophic Factor in Type 2 Diabetic Subjects Treated with Amlodipine/Benazepril or Valsartan/Hydrochlorothiazide." Disease Markers 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/780743.

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Background. Brain-derived neurotrophic factor (BDNF) is associated with sympathetic activation. However, the effects of BDNF on diabetic nephropathy are unknown. The aim of this study was to assess the estimated glomerular filtration rates (eGFRs) and changes in serum BDNF levels in type 2 diabetic subjects treated with antihypertensive medications.Methods. In this randomized, double-blind clinical trial, type 2 diabetic subjects with hypertension were assigned to either the benazepril/amlodipine or valsartan/hydrochlorothiazide treatment groups for a 16-week period. The post hoc analyses were
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Beitollahi, Hadi, Farshid Ebadinejad, Fahimeh Shojaie, and Masoud Torkzadeh-Mahani. "A magnetic core–shell Fe3O4@SiO2/MWCNT nanocomposite modified carbon paste electrode for amplified electrochemical sensing of amlodipine and hydrochlorothiazide." Analytical Methods 8, no. 32 (2016): 6185–93. http://dx.doi.org/10.1039/c6ay01438k.

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12

Tandililing, Senfri, Alwiyah Mukaddas, and Ingrid Faustine. "Profil Penggunaan Obat Pasien Hipertensi Esensial Di Instalasi Rawat Jalan Rumah Sakit Umum Daerah I Lagaligo Kabupaten Luwu Timur Periode Januari-Desember Tahun 2014." Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) 3, no. 1 (2017): 49–56. http://dx.doi.org/10.22487/j24428744.2017.v3.i1.8139.

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This study aimed to determine the demographic and clinical characteristics and profile of drug use in patients with essential hypertension at outpatient installations I Lagaligo General Hospital East Luwu Regency period January-December 2014. The research method is descriptive done retrospectively by collecting secondary data from medical records essential hypertension patients undergoing outpatient treatment at General Hospital I Lagaligo East Luwu Regency period January-December 2014. The number of samples in the study were 145 patients. The dominant demographic characteristics of women that
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Umegbolu, Emmanuel I. "Prescribing patterns in systemic hypertension and pharmaco-economics (cost effectiveness and cost minimisation analyses) of the commonly prescribed antihypertensives in a district hospital in Enugu State, Southeast Nigeria." International Journal of Research in Medical Sciences 6, no. 1 (2017): 20. http://dx.doi.org/10.18203/2320-6012.ijrms20175706.

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Background: Prescribing patterns in systemic hypertension vary from place to place. Studies have shown that cost could be one of the factors responsible for non-adherence to treatment among hypertensive patients. Nigerian pharmacoeconomics studies have not provided a general guide on cost-effective prescribing for hypertensive patients in the country. The aim of the study was to examine the prescribing patterns, do cost effectiveness and cost minimisation analyses of the commonly prescribed antihypertensives, and determine if cost is a major reason many of the hypertensive patients of the Dist
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14

Sundström, Johan, Lars Lind, Shamim Nowrouzi, et al. "Heterogeneity in Blood Pressure Response to 4 Antihypertensive Drugs." JAMA 329, no. 14 (2023): 1160. http://dx.doi.org/10.1001/jama.2023.3322.

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ImportanceHypertension is the leading risk factor for premature death worldwide. Multiple blood pressure–lowering therapies are available but the potential for maximizing benefit by personalized targeting of drug classes is unknown.ObjectiveTo investigate and quantify the potential for targeting specific drugs to specific individuals to maximize blood pressure effects.Design, Setting, and ParticipantsA randomized, double-blind, repeated crossover trial in men and women with grade 1 hypertension at low risk for cardiovascular events at an outpatient research clinic in Sweden. Mixed-effects mode
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15

Soboleva, M. S., and E. E. Loskutova. "Analysis of acquisition and the monthly cost of antihypertensive therapy with modern fixed-dose combinations in the Far Eastern Federal District." FARMAKOEKONOMIKA. Modern Pharmacoeconomic and Pharmacoepidemiology 14, no. 1 (2021): 41–49. http://dx.doi.org/10.17749/2070-4909/farmakoekonomika.2021.061.

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Objective: analyzing the acquisition and monthly costs for patients on modern fixed-dose antihypertensive combinations in three regions of the Far Eastern Federal District.Material and methods. Intra-group analysis of retail of antihypertensive drugs for 2019 in drugstores of the Khabarovsk Region, Sakhalin Region, Amur Region (n=100) was carried out. The calculation of the monthly cost of therapy was performed and total sales indicators were identified. Statistical analysis: dispersion analysis, Spearman's rank correlation coefficient, Kruskal–Wallis test.Results. The maximum demand in patien
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Sirenko, Yu M., O. L. Rekovets, G. D. Radchenko, et al. "Influence fixed combination therapy on arterial stiffness and erectile function in patients with arterial hypertension." Ukrainian Journal of Cardiology 28, no. 3 (2021): 20–29. http://dx.doi.org/10.31928/1608-635x-2021.3.2029.

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The aim – to evaluate the therapeutic efficacy and dynamics of arterial stiffness using сardio-ankle vascular index (CAVI), as well as the dynamics of erectile function in men of the generic fixed triple combination of valsartan/amlodipine/hydrochlorothiazide and a double fixed combination of valsartan/amlodipine in the treatment of patients with arterial hypertension II–III degree. Materials and methods. The study included patients with moderate and severe arterial hypertension without diabetes. Patients were divided into 2 groups by the method of envelopes of 25 each. The first group (n=25)
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Mansano, Guilherme Roberto, Ana Paula Pires Eisele, and Elen Romão Sartori. "Electrochemical evaluation of a boron-doped diamond electrode for simultaneous determination of an antihypertensive ternary mixture of amlodipine, hydrochlorothiazide and valsartan in pharmaceuticals." Analytical Methods 7, no. 3 (2015): 1053–60. http://dx.doi.org/10.1039/c4ay02511c.

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18

Groenland, Eline H., Monique E. A. M. van Kleef, Michiel L. Bots, Frank L. J. Visseren, Kim C. M. van der Elst, and Wilko Spiering. "Plasma Trough Concentrations of Antihypertensive Drugs for the Assessment of Treatment Adherence." Hypertension 77, no. 1 (2021): 85–93. http://dx.doi.org/10.1161/hypertensionaha.120.16061.

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Biochemical drug screening by liquid chromatography-tandem mass spectrometry in plasma is an accurate method for the quantification of plasma concentrations of antihypertensive medications in patients with hypertension. Trough concentrations could possibly be used as drug-specific cutoff values in the biochemical assessment of (non-)adherence. We performed a literature review and meta-analysis of pharmacokinetic studies to determine plasma trough concentrations of amlodipine, hydrochlorothiazide, and valsartan. PubMed was searched for pharmacokinetic studies up to September 2020. Eligible stud
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Farvardin, Najmeh, Shohreh Jahani, Maryam Kazemipour, and Mohammad Mehdi Foroughi. "The synthesis and characterization of 3D mesoporous CeO2 hollow spheres as a modifier for the simultaneous determination of amlodipine, hydrochlorothiazide and valsartan." Analytical Methods 12, no. 13 (2020): 1767–78. http://dx.doi.org/10.1039/d0ay00022a.

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20

Ghule, A. S., T. Thomas, M. Joseph, K. S. Navya Sree, and K. Bhat. "SIMULTANEOUS ESTIMATION OF TELMISARTAN, HYDROCHLOROTHIAZIDE AND AMLODIPINE BESYLATE IN TABLET PREPARATION BY CHEMOMETRIC ASSISTED SPECTROPHOTOMETRIC ANALYSIS." INDIAN DRUGS 55, no. 07 (2018): 59–66. http://dx.doi.org/10.53879/id.55.07.11109.

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A chemometric method was developed by application of Partial Least Square regression to for the simultaneous estimation of telmisartan, hydrochlorothiazide and amlodipine besylate in tablet preparations. Calibration set was prepared considering seven sets; each set with twenty-four mixed solutions and twenty-one ternary mixed solutions, were prepared as a validation set. The absorbance data matrix for training set was obtained by recording absorbance within wavelength range 220-320 nm at 2nm intervals. The developed method was validated according to ICH Q2 (R1) guidelines and results were repo
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Dessislava Vladimirova Ilieva-Tonova, Ivanka Petkova Pencheva-El Tibi, and Assena Christova Serbezova. "UV spectrophotometric test for analysis of antihypertensive drug combinations containing amlodipine." World Journal of Advanced Pharmaceutical and Life Sciences 2, no. 1 (2022): 001–8. http://dx.doi.org/10.53346/wjapls.2022.2.1.0036.

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The present study provides rapid test for the identity and quantification of Amlodipine besylate as monoproduct and in double and triple antihypertensive drug combinations. Test represents direct analysis - drug mixtures are analyzed in solution without prior separation using UV-VIS spectrophotometry. The spectral characteristics of the complex spectrum are used for authentication, counterfeiting, identification and assay. Basic spectral characteristics are determined and analytical parameters of the validation process are investigated. The method uses 4 types of calculations for normal and de
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Katkale, Akshay, Sagar Fodase, Ashok Pingle, Ganesh Dhikale, Pratik Waghmare, and Deepak Dhake. "Simultaneous Analysis of Anti-Hypertensive Drugs by RP-HPLC: An Overview." Asian Journal of Pharmaceutical Research and Development 12, no. 1 (2024): 87–97. http://dx.doi.org/10.22270/ajprd.v12i1.1355.

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High performance liquid chromatography (HPLC) is an important qualitative and quantitative technique, generally used for the estimation of pharmaceutical and biological samples. In now a day pharmaceutical market, many newer antihypertensive combination drugs are available to control hypertension as well as to keep society healthy and stress free. All presently available old drugs have frequent dosing produces various side effects. So, there is need to analyse such antihypertensive drugs. The aim of this review is to analysed such commonly used antihypertensive combination drugs by using rever
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Vichairuangthum, Kitigon, and Paiboon Chotnaparatpat. "Efficacy and Safety of Aliskiren/Amlodipine or Aliskiren/Amlodipine/Hydrochlorothiazide Combinations." Journal of Hypertension 33 (June 2015): e5. http://dx.doi.org/10.1097/01.hjh.0000469736.42759.ce.

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Ostroumova, O. D., A. I. Kochetkov, F. T. Ageev, et al. "The Effects of Telmisartan and Its Combinations on Office Blood Pressure: Results of Prospective Observational Study TAINA." Rational Pharmacotherapy in Cardiology 16, no. 2 (2020): 175–90. http://dx.doi.org/10.20996/1819-6446-2020-04-07.

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Aim. To evaluate the effectiveness and safety of telmisartan, used in monotherapy or in combination with hydrochlorothiazide or amlodipine, in real clinical practice in patients with diagnosed arterial hypertension who have not reached the target levels of blood pressure (BP).Material and methods. The study was a non-intervention, prospective, multicenter, comparative, observational, epidemiological program, which was carried out in Russian medical institutions. The total patient population in which the prescribed therapy was administered included 1933 people (758 men and 1175 women, mean age
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Barrios, Vivencio, and Carlos Escobar. "Valsartan–amlodipine–hydrochlorothiazide: the definitive fixed combination?" Expert Review of Cardiovascular Therapy 8, no. 11 (2010): 1609–18. http://dx.doi.org/10.1586/erc.10.115.

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Rekovets, Oksana, Yuriy Sirenko, and Sergey Progonov. "Study of the effect of different drug treatment strategies in patients with hypertension." Ukrainian Scientific Medical Youth Journal 144, no. 1 (2024): 61–75. http://dx.doi.org/10.32345/usmyj.1(144).2024.61-75.

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fixed combinations of antihypertensive medications can improve blood pressure (BP) control, reduce complications and increase life expectancy. The objective of our study was to analyze the efficiency of fixed, free and not traditional combinations of antihypertensive medications in the management of patients with arterial hypertension. 396 patients with hypertension with various degrees of its severity were examined. The inclusion criteria were the age of patients older than 18 years and the level of office BP greater than 140/90 mm Hg. Patients were in three observational groups: traditional
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NELDAM, S. "Telmisartan + hydrochlorothiazide versus amlodipine + hydrochlorothiazide in older patients with predominantly systolic hypertension." American Journal of Hypertension 18, no. 5 (2005): A90—A91. http://dx.doi.org/10.1016/j.amjhyper.2005.03.252.

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28

Sagarad, Suresh V., and Hari Prasad S. "A prospective and open label study of use of cilnidipine and chlorthalidone fixed dose combination in Indian hypertensive patients, intolerant or uncontrolled on amlodipine and hydrochlorothiazide combination." International Journal of Advances in Medicine 4, no. 6 (2017): 1522. http://dx.doi.org/10.18203/2349-3933.ijam20174673.

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Background:Primary aim of this study was to evaluate the antihypertensive efficacy of the Cilnidipine and Chlorthalidone fixed dose combination in Indian hypertensive patients who are not controlled on traditionally used amlodipine and hydrochlorothiazide combination and also to evaluate the safety of this combination.Methods: A total of 70 eligible patients were enrolled in this prospective, open label study. The patients were given cilnidipine (10 mg) and chlorthalidone (12.5 mg) who had not achieved target blood pressure (140/90 mmHg) despite on amlodipine (5 mg) and hydrochlorothiazide (12
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Sawant, Swati D., Sanjeevani M. Chawre, Kalpana S. Dudhal, and Amit A. Bansode. "Evaluation of losartan plus hydrochlorothiazide combination therapy against amlodipine monotherapy in patients of hypertension." International Journal of Basic & Clinical Pharmacology 8, no. 11 (2019): 2528. http://dx.doi.org/10.18203/2319-2003.ijbcp20194797.

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Background: Microalbuminuria has been shown to predict cardiovascular disease (CVD) in patients with hypertension. Recently the FDC of losartan and hydrochlorothiazide (HCTZ) has been reported to be effective for achieving a target BP level and also improvement in cardiovascular prognosis. The present study was conducted to compare effect of losartan plus hydrochlorothiazide combination therapy and high dose amlodipine monotherapy on blood pressure and microalbuminuria.Methods: Total 184 patients with hypertension were randomly allocated to two groups. The patients in group 1 received Amlodipi
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PRISANT. "E087 Assessment of sexual dysfunction with bisoprolol/hydrochlorothiazide, bisoprolol, hydrochlorothiazide, enalapril and amlodipine." American Journal of Hypertension 11, no. 4 (1998): 117A. http://dx.doi.org/10.1016/s0895-7061(97)91149-3.

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31

Chrysant, Steven G., Catherine Chrysant, Joanna Trus, and Anne Hitchcock. "Antihypertensive Effectiveness of Amlodipine in Combination With Hydrochlorothiazide." American Journal of Hypertension 2, no. 7 (1989): 537–41. http://dx.doi.org/10.1093/ajh/2.7.537.

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32

Calhoun, David A., Yves Lacourcière, Yann Tong Chiang, and Robert D. Glazer. "Triple Antihypertensive Therapy With Amlodipine, Valsartan, and Hydrochlorothiazide." Hypertension 54, no. 1 (2009): 32–39. http://dx.doi.org/10.1161/hypertensionaha.109.131300.

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Judd, Eric, and Edgar A. Jaimes. "Aliskiren, amlodipine and hydrochlorothiazide triple combination for hypertension." Expert Review of Cardiovascular Therapy 10, no. 3 (2012): 293–303. http://dx.doi.org/10.1586/erc.12.7.

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Ageev, F. T., and M. D. Smirnova. "Clinical Efficacy and Tolerability of Antihypertensive Therapy with Single Pill Combinations of Telmisartan in Patients with Arterial Hypertension in Clinical Practice According to the ON TIME Observational Study." Rational Pharmacotherapy in Cardiology 18, no. 6 (2023): 638–47. http://dx.doi.org/10.20996/1819-6446-2022-12-01.

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Aim. To assess the clinical outcomes and tolerability of antihypertensive therapy with single pill combinations (SPC) amlodipine + telmisartan and hydrochlorothiazide + telmisartan in clinical practice.Material and methods. Patients with hypertension of grade 1-3 (n=13647; 57.6% women; age 59.3±11.4 years) who received therapy with SPC amlodipine + telmisartan or hydrochlorothiazide + telmisartan were included in an observational multicenter study. Information on complaints, history, previous therapy, history of novel coronavirus infection (COVID-19) during the previous year was obtained. Also
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Karim, Abdul, Sarwat Iqbal, Shabbir Ali Bhatti, Mujeeb-ur-Rehman Abid, Naveed Iqbal, and Asad Ejaz. "Efficacy, Safety and Tolerability of Valsartan and Hydrochlorothiazide Compared to Valsartan and Amlodipine in Stage 2 Hypertension." Journal of Shalamar Medical & Dental College - JSHMDC 3, no. 1 (2022): 120–27. http://dx.doi.org/10.53685/jshmdc.v3i1.94.

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Background: Hypertension is a growing medical and public health issue. The United States and European treatment guidelines have been issued to attain smooth control of hypertension in various categories of patients. It is a need of time to unveil safe combination therapies in various populations. Objectives: (i) To determine the efficacy of valsartan and hydrochlorothiazide versus valsartan and amlodipine (ii) To determine the safety and tolerability of both combinations. Materials & Methods: This experimental study was conducted at Shalamar Hospital Lahore. 126 patients with stage 2 hyper
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Niushko, Tetiana Y., Olena K. Tarasiuk, and Yulia K. Sikalo. "THE EFFECTIVENESS OF COMBINATED ANTIHYPERTENSIVE TREATMENT IN PATIENTS WITH ESSENTIAL HYPERTENSION OF THE II-ND STAGE DEPENDING ON THE TYPE OF DAILY BLOOD PRESSURE PROFILE AND THE TYPE OF REMODELLING OF THE LEFT VENTRICLE." Wiadomości Lekarskie 73, no. 1 (2020): 46–51. http://dx.doi.org/10.36740/wlek202001108.

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The aim: To evaluate the dynamics of structural and functional parameters of the heart, vessels in patients with hypertension of the II-nd stage under the influence of combined antihypertensive treatment depending on the type of the left ventricle remodelling and the profile of blood pressure (BP). Materials and methods: The study involved 110 patients with hypertension of the II-nd stage. The ambulatory blood pressure monitoring, echocardiography and Doppler examination of the shoulder arteries were performed. Initial treatment included bisoprolol, lisinopril, hydrochlorothiazide. With imposs
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Darwish, Hany W., Said A. Hassan, Maissa Y. Salem, and Badr A. El-Zeany. "Sequential Spectrophotometric Method for the Simultaneous Determination of Amlodipine, Valsartan, and Hydrochlorothiazide in Coformulated Tablets." International Journal of Spectroscopy 2013 (December 15, 2013): 1–8. http://dx.doi.org/10.1155/2013/273102.

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A new, simple and specific spectrophotometric method was developed and validated in accordance with ICH guidelines for the simultaneous estimation of Amlodipine (AML), Valsartan (VAL), and Hydrochlorothiazide (HCT) in their ternary mixture. In this method three techniques were used, namely, direct spectrophotometry, ratio subtraction, and isoabsorptive point. Amlodipine (AML) was first determined by direct spectrophotometry and then ratio subtraction was applied to remove the AML spectrum from the mixture spectrum. Hydrochlorothiazide (HCT) could then be determined directly without interferenc
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Nandeesha, Hanumanthappa, Purushothaman Pavithran, and T. Madanmohan. "Effect of Antihypertensive Therapy on Serum Lipids in Newly Diagnosed Essential Hypertensive Men." Angiology 60, no. 2 (2008): 217–20. http://dx.doi.org/10.1177/0003319708316167.

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The effect of antihypertensives on serum lipids in newly diagnosed male essential hypertensive patients was studied. The participants (n = 99) were randomly allocated to receive amlodipine, atenolol, enalapril, hydrochlorothiazide, and a combination of amlodipine and atenolol. Lipid parameters were estimated before and after 8 weeks of therapy. The atenolol and thiazide group showed a significant increase in triglycerides (TGs) and very-low-density lipoprotein cholesterol (VLDL-C). High-density lipoprotein cholesterol (HDL-C) and HDL-C to low-density lipoprotein cholesterol (LDL-C) ratio were
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39

Posse, Veronica, Clara Ryu, Cesar Romero, and Sihyun Jeon. "O81 EFFECT OF ANTIHYPERTENSIVE MEDICATIONS ON URINARY SODIUM TO POTASSIUM (Na/K) RATIO." Journal of Hypertension 42, Suppl 3 (2024): e37. http://dx.doi.org/10.1097/01.hjh.0001062764.10428.d3.

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Background: The urinary sodium to potassium ratio (Na/K) greater than 2 indicating either excess sodium or insufficient potassium intake. However, the effect of antihypertensive medications on the urinary Na/K ratio has not been evaluated. We hypothesized that antihypertensive medication would acutely affect the urinary Na/K ratio. Methods: Male and female C57BL/6J mice, 14 weeks old, and a separate cohort of 24-month-old mice were subjected to a regular chow diet (NaCl 0.4%) and a high salt diet (4%). Urinary Na/K ratios in spot urine samples were measured three times a week. After baseline m
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40

Sai, Keerthana P. C. 1. Midhun M. Nair2 *. Thahsin3 Shifna E. P. 4. Shirin5. "Losartan-H Induced Steven Johnson's Syndrome – A Case Report." International Journal in Pharmaceutical Sciences 2, no. 3 (2024): 155–60. https://doi.org/10.5281/zenodo.10792598.

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Steven Johnson’s Syndrome (SJS) is a life-threatening mucocutaneous reaction characterized by skin detachment and blistering. SJS is most commonly triggered by medications, characterized by extensive necrosis and detachment of the epidermis. This case report delves into a rare adverse drug reaction involving Losartan, an angiotensin II receptor antagonist, and hydrochlorothiazide which is a diuretic commonly used for hypertension. A 72-year-old female developed Steven Johnson Syndrome (SJS) after administration of a Losartan-Hydrochlorothiazide combination., the patient’s past medi
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41

Soares, Cristiane Regina, and Meiry Fernanda Pinto Okuno. "Análise das potenciais interações medicamentosas e eventos adversos." Revista Remecs - Revista Multidisciplinar de Estudos Cientí­ficos em Saúde 9, no. 15 (2024): 68–81. http://dx.doi.org/10.24281/rremecs2024.9.15.6881.

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Analisar as potenciais interações medicamentosas e os eventos adversos. Estudo transversal e quantitativo, realizado em um ambulatório na cidade de São Paulo - SP, com 117 idosos, no período de março a novembro de 2019. A coleta de dados foi realizada pela transcrição integral dos receituários, as interações medicamentos foram analisadas na base de dados Drugs.com. e, após, realizada análise por estatística descritiva. Na categoria grave, 40% foram entre o anlodipino versus a sinvastatina, as moderadas, entre a hidroclorotiazida versus a metformina (5,8%) e as leves entre a hidroclorotiazida v
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42

Cho, Eun Joo, Hae Young Lee, Ki Chul Sung, et al. "Comparison of 24-Hour Ambulatory Central Blood Pressure Reduction Efficacy Between Fixed Amlodipine or Up-Titrated Hydrochlorothiazide Plus Losartan: The K-Central Study." American Journal of Hypertension 32, no. 10 (2019): 992–1002. http://dx.doi.org/10.1093/ajh/hpz050.

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Abstract OBJECTIVE The main objective of this study was to evaluate non-inferiority of office mean systolic blood pressure (BP) reduction efficacy and superiority of 24-hour ambulatory central BP reduction efficacy between losartan combined with fixed dose amlodipine (L/A group) and dose up-titrated hydrochlorothiazide (L/H group) according to office BP. METHODS We conducted a prospective, randomized, double-blind multicenter trial in 231 patients with hypertensive (mean age = 59.2 ± 12.2 years). Patients received losartan 50 mg monotherapy for 4 weeks, followed by additional use of amlodipine
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43

Soboleva, M. S., and E. E. Loskutova. "Dynamics of the sales of fixed-doses antihypertensive combinations in the southern regions of the far Eastern federal district." "Arterial’naya Gipertenziya" ("Arterial Hypertension") 24, no. 4 (2018): 469–77. http://dx.doi.org/10.18705/1607-419x-2018-24-4-469-477.

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Background. Advantages of the two-component drugs are well-known and described in the professional standards and guidelines. However, in clinical practice their application is often limited, despite the increase in the variants of full-doses combinations.Objective. To analyze the dynamics of sales of the fixed-doses antihypertensive combinations in regions of the Far Eastern federal district.Design and methods. We present the results of the pharmacoepidemiological study of the regional pharmaceutical market of the antihypertensive fixeddoses combinations in Khabarovskii, Primorskii region and
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44

Borodulina, A. D., E. O. Kutumova, G. I. Lifshits, and F. A. Kolpakov. "Mathematical Modeling of Antihypertensive Therapy with Azilsartan Medoxomil on the Example of Clinical Data of a Real Patient." Mathematical Biology and Bioinformatics 18, no. 1 (2023): 228–50. http://dx.doi.org/10.17537/2023.18.228.

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Hypertension is a pathology caused by increased systolic and/or diastolic blood pressure. The disease can be controlled by various antihypertensive drugs. This study simulates the response of the human cardiovascular and renal systems to the action of the angiotensin II receptor blocker azilsartan medoxomil, taking into account dual combinations of this drug with the thiazide diuretic hydrochlorothiazide, the $upbeta$-blocker bisoprolol and the calcium channel blocker amlodipine. For this purpose, we consider an agent-based mathematical model of blood pressure regulation, previously developed
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45

Ram, C. Venkata S. "Olmesartan medoxomil, amlodipine besylate and hydrochlorothiazide triple combination for hypertension." Expert Review of Cardiovascular Therapy 9, no. 1 (2011): 9–19. http://dx.doi.org/10.1586/erc.10.163.

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46

Shangwen, S., L. Fanghong, Z. Yingxin, W. Shujian, and L. Zhendong. "Effects of amlodipine plus amiloride/hydrochlorothiazide versus amlodipine plus telmisartan on carotid atherosclerosis in hypertensive patients." Heart 97, Suppl 3 (2011): A116. http://dx.doi.org/10.1136/heartjnl-2011-300867.344.

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47

Sison, Jorge, Samir Helmy Assaad-Khalil, Robert Najem, et al. "Real-world clinical experience of amlodipine/valsartan and amlodipine/valsartan/hydrochlorothiazide in hypertension: the EXCITE study." Current Medical Research and Opinion 30, no. 10 (2014): 1937–45. http://dx.doi.org/10.1185/03007995.2014.942415.

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48

Kaila, Harshad O., Mrunal A. Ambasana, and Anamik K. Shah. "Development and Validation of a Reversed-Phase Ultra-Performance Liquid Chromatographic Method for the Simultaneous Determination of Six Drugs Used for Combined Hypertension Therapy." Journal of AOAC INTERNATIONAL 96, no. 2 (2013): 295–300. http://dx.doi.org/10.5740/jaoacint.10-466.

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Abstract A simple, rapid, and reliable ultra-performance LC assay method has been developed for the simultaneous estimation of orally administered hypertension drugs (atenolol, hydrochlorothiazide, amlodipine besylate, indapamide, nifedipine, and lercanidipine hydrochloride), any of which may be administered with atenolol in combined hypertension therapy. Chromatography was carried out at 25°C on a 2.1 × 50 mm id, 1.7 μm particle size Acquity BEH C18 column with the isocratic mobile phase 0.01 M, 4.0 pH aqueous phosphate buffer–acetonitrile (50 + 50, v/v) at a flow rate of 0.35 mL/min. All dru
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49

Wu, Patrick, Scott D. Nelson, Juan Zhao, et al. "DDIWAS: High-throughput electronic health record-based screening of drug-drug interactions." Journal of the American Medical Informatics Association 28, no. 7 (2021): 1421–30. http://dx.doi.org/10.1093/jamia/ocab019.

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Abstract Objective We developed and evaluated Drug-Drug Interaction Wide Association Study (DDIWAS). This novel method detects potential drug-drug interactions (DDIs) by leveraging data from the electronic health record (EHR) allergy list. Materials and Methods To identify potential DDIs, DDIWAS scans for drug pairs that are frequently documented together on the allergy list. Using deidentified medical records, we tested 616 drugs for potential DDIs with simvastatin (a common lipid-lowering drug) and amlodipine (a common blood-pressure lowering drug). We evaluated the performance to rediscover
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50

Bubnova, Marina Gennad'evna. "Perspektivy klinicheskogo primeneniyanovoy fiksirovannoy kombinatsii -preparata Ko-Eksforzh v lecheniiarterial'noy gipertonii." CardioSomatics 2, no. 1 (2011): 64–71. http://dx.doi.org/10.26442/cs44978.

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Summary. This review is concerned with improving of blood pressure (BP) control in patients with arterial hypertension (AH). The reasons for the low treatment compliance and combined antihypertensive therapy benefits are analyzed. Data for futility of an extended use of antihypertensive drugs (AHD) fixed combinations are given. Studies demonstrating high efficacy and safety of a new triple fixed combination of amlodipine, valsartan and hydrochlorothiazide (HCT) are presented as well. Patients with hypertension, which should more actively use this combination of drugs, are signified.
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