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Relevant bibliographies by topics / Amoebicide

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Academic literature on the topic 'Amoebicide'

Author: Grafiati

Published: 4 June 2021

Last updated: 9 February 2022

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Journal articles on the topic "Amoebicide"

1

Martín-Pérez, Tania, Irene Heredero-Bermejo, Cristina Verdú-Expósito, and Jorge Pérez-Serrano. "In Vitro Evaluation of the Combination of Melaleuca alternifolia (Tea Tree) Oil and Dimethyl Sulfoxide (DMSO) against Trophozoites and Cysts of Acanthamoeba Strains. Oxygen Consumption Rate (OCR) Assay as a Method for Drug Screening." Pathogens 10, no. 4 (April 19, 2021): 491. http://dx.doi.org/10.3390/pathogens10040491.

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Ameobae belonging to the genus Acanthamoeba are responsible for the human diseases Acanthamoeba keratitis (AK) and granulomatous amoebic encephalitis (GAE). The treatment of these illnesses is hampered by the existence of a resistance stage (cysts). In an attempt to add new agents that are effective against trophozoites and cysts, tea tree oil (TTO) and dimethyl sulfoxide (DMSO), separately and in combination, were tested In Vitro against two Acanthamoeba isolates, T3 and T4 genotypes. The oxygen consumption rate (OCR) assay was used as a drug screening method, which is to some extent useful in amoebicide drug screening; however, evaluation of lethal effects may be misleading when testing products that promote encystment. Trophozoite viability analysis showed that the effectiveness of the combination of both compounds is higher than when either compound is used alone. Therefore, the TTO alone or TTO + DMSO in combination were an amoebicide, but most of the amoebicidal activity in the combination’s treatments seemed to be caused mainly by the TTO effect. In fact, DMSO alone seems to be a non-amoebicide, triggering encystment. Regarding cytotoxicity, these compounds showed toxicity in human corneal epithelial cells (HCEpiC), even at low concentrations when tested in combination. In conclusion, the use of TTO and DMSO, in combination or alone, cannot be recommended as an alternative for AK treatment until more cytotoxicity and cyst adhesion tests are performed.

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Beugelmans, René, Michèle Bois-Choussy, Philippe Gayral, and Marie Christine Rigothier. "Synthèse par SRN1 et évaluation de l'activité amoebicide de nouveaux dérivés quinoléiniques." European Journal of Medicinal Chemistry 23, no. 6 (November 1988): 539–46. http://dx.doi.org/10.1016/0223-5234(88)90097-9.

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Toledano-Magaña, Yanis, Ruth Meléndrez-Luévano, Marisol Navarro-Olivarria, Juan Carlos García-Ramos, Marcos Flores-Alamo, Luis Ortiz-Frade, Lena Ruiz-Azuara, and Blanca M. Cabrera-Vivas. "Synthesis, characterization and evaluation of the substituent effect on the amoebicide activity of new hydrazone derivatives." Med. Chem. Commun. 5, no. 7 (2014): 989–96. http://dx.doi.org/10.1039/c4md00075g.

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Santos, André L., Regina M. Takeuchi, Nelson R. Stradiotto, Ana Paula Esteves, and Maria José Medeiros. "Study of the electrochemical reduction of amoebicide teclozan and its amperometric determination in pharmaceutical formulations." Journal of the Brazilian Chemical Society 19, no. 6 (2008): 1144–52. http://dx.doi.org/10.1590/s0103-50532008000600014.

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García-Ramos, Juan Carlos, Yanis Toledano-Magaña, Luis Gabriel Talavera-Contreras, Marcos Flores-Álamo, Vanessa Ramírez-Delgado, Emmanuel Morales-León, Luis Ortiz-Frade, et al. "Potential cytotoxic and amoebicide activity of first row transition metal compounds with 2,9-bis-(2′,5′-diazahexanyl)-1,1-phenanthroline (L1)." Dalton Transactions 41, no. 34 (2012): 10164. http://dx.doi.org/10.1039/c2dt30224a.

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Tomita, Shinichi, Chie Suzuki, Hitomi Wada, Miya Nomachi, Masaki Imayasu, and Kaoru Araki-Sasaki. "Effects of lactoferrin on the viability and the encystment of Acanthamoeba trophozoites." Biochemistry and Cell Biology 95, no. 1 (February 2017): 48–52. http://dx.doi.org/10.1139/bcb-2016-0054.

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Lactoferrin (LF) is an iron-binding basic glycoprotein that has an antimicrobial effect against certain microbes. The purpose of this study is to evaluate the amoebicidal effect of bovine milk LF (bLF) against Acanthamoeba clinical-isolate trophozoites, which cause severe keratitis. Most of the risk factor for Acanthamoeba keratitis is from wearing soft contact lenses (SCLs). Acanthamoeba trophozoites were incubated in bovine LF (bLF) solution, and the ratios of viability and encystment were determined with microscopic analysis of cyst formation. The amoebicidal effect of bLF was assessed by Trypan blue assay. The ratios of viable cells in the presence of iron-free bLF (apo-bLF), native-bLF, and iron-saturated bLF (Fe-bLF) at the concentration of 10 μmol/L for 60 min were 7.7% ± 4.6%, 80.7% ± 10.1%, and 97.3% ± 1.5%, respectively. Apo-bLF showed potent amoebicidal effect against Acanthamoeba trophozoites, but Fe-bLF did not have this effect. After treating with apo-bLF, most dead cells were nonglobular forms of trophozoites but not cystic forms. Encystment of Acanthamoeba was assessed by the sarkosyl-calcofluor white assay. The encystment ratios treated with 0.5% propylene glycol (positive control) and 10 μmol/L apo-bLF for 24 h were 96.12% ± 10.6% and 0.47% ± 0.5%, respectively. These results suggest that the amoebicidal effect of apo-bLF without encystment might lead to the prevention of contamination of Acanthamoeba in SCL stock cases.

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Venugopalan, B., B. Patel, PJ Karnik, NJ de Souza, DK Chatterjee, and N. Iyer. "Synthesis of diphenyl bisamidines as potential amoebicides." European Journal of Medicinal Chemistry 31, no. 6 (January 1996): 485–88. http://dx.doi.org/10.1016/0223-5234(96)85169-5.

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Anwar, Ayaz, Mohammad Ridwane Mungroo, Simal Khan, Itrat Fatima, Rafaila Rafique, Kanwal, Khalid Mohammed Khan, Ruqaiyyah Siddiqui, and Naveed Ahmed Khan. "Novel Azoles as Antiparasitic Remedies against Brain-Eating Amoebae." Antibiotics 9, no. 4 (April 17, 2020): 188. http://dx.doi.org/10.3390/antibiotics9040188.

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Balamuthia mandrillaris and Naegleria fowleri are opportunistic protozoan pathogens capable of producing infection of the central nervous system with more than 95% mortality rate. Previously, we have synthesized several compounds with antiamoebic properties; however, synthesis of compounds that are analogues of clinically used drugs is a highly desirable approach that can lead to effective drug development against these devastating infections. In this regard, compounds belonging to the azole class possess wide range of antimicrobial properties and used clinically. In this study, six novel benzimidazole, indazole, and tetrazole derivatives were synthesized and tested against brain-eating amoebae. These compounds were tested for their amoebicidal and static properties against N. fowleri and B. mandrillaris. Furthermore, the compounds were conjugated with silver nanoparticles and characterized. The synthetic heterocyclic compounds showed up to 72% and 65% amoebicidal activities against N. fowleri and B. mandrillaris respectively, while expressing up to 75% and 70% amoebistatic activities, respectively. Following conjugation with silver nanoparticles, amoebicidal activities of the drugs increased by up to 46 and 36% versus B. mandrillaris and N. fowleri. Minimal effects were observed when the compounds were evaluated against human cells using cytotoxicity assays. In summary, azole compounds exhibited potent activity against N. fowleri and B. mandrillaris. Moreover, conjugation of the azole compounds with silver nanoparticles further augmented the capabilities of the compounds against amoebae.

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Derda, Monika, Edward Hadaś, and Barbara Thiem. "Plant extracts as natural amoebicidal agents." Parasitology Research 104, no. 3 (December 3, 2008): 705–8. http://dx.doi.org/10.1007/s00436-008-1277-9.

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Baig, Abdul Mannan, Junaid Iqbal, and Naveed Ahmed Khan. "In VitroEfficacies of Clinically Available Drugs against Growth and Viability of an Acanthamoeba castellanii Keratitis Isolate Belonging to the T4 Genotype." Antimicrobial Agents and Chemotherapy 57, no. 8 (May 13, 2013): 3561–67. http://dx.doi.org/10.1128/aac.00299-13.

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ABSTRACTThe effects of clinically available drugs targeting muscarinic cholinergic, adrenergic, dopaminergic, and serotonergic receptors; intracellular calcium levels and/or the function of calcium-dependent biochemical pathways; ion channels; and cellular pumps were tested against a keratitis isolate ofAcanthamoeba castellaniibelonging to the T4 genotype.In vitrogrowth inhibition (amoebistatic) assays were performed by incubatingA. castellaniiwith various concentrations of drugs in the growth medium for 48 h at 30°C. To determine amoebicidal effects, amoebae were incubated with drugs in phosphate-buffered saline for 24 h, and viability was determined using trypan blue exclusion staining. For controls, amoebae were incubated with the solvent alone. Of the eight drugs tested, amlodipine, prochlorperazine, and loperamide showed potent amoebicidal effects, as no viable trophozoites were observed (>95% kill rate), while amiodarone, procyclidine, digoxin, and apomorphine exhibited up to 50% amoebicidal effects. In contrast, haloperidol did not affect viability, but all the drugs tested inhibitedA. castellaniigrowth. Importantly, amlodipine, prochlorperazine, and loperamide showed compelling cysticidal effects. The cysticidal effects were irreversible, as cysts treated with the aforementioned drugs did not reemerge as viable amoebae upon inoculation in the growth medium. Except for apomorphine and haloperidol, all the tested drugs blocked trophozoite differentiation into cysts in encystation assays. Given the limited availability of effective drugs to treat amoebal infections, the clinically available drugs tested in this study represent potential agents for managing keratitis and granulomatous amoebic encephalitis caused byAcanthamoebaspp. and possibly against other meningoencephalitis-causing amoebae, such asBalamuthia mandrillarisandNaegleria fowleri.

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Dissertations / Theses on the topic "Amoebicide"

1

ROUSSEL, BESOMI MICHELE. "A propos de cinq cas de resistance d'amibiases coliques communes a des traitements associant 5-nitro-imidazole et amoebicide de contact (type difetarsone)." Aix-Marseille 2, 1990. http://www.theses.fr/1990AIX20266.

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Chadapaud, Sylviane. ""Simaruba amara"." Paris 5, 1997. http://www.theses.fr/1997PA05P077.

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Book chapters on the topic "Amoebicide"

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Mehlhorn, Heinz. "Amoebicides." In Encyclopedia of Parasitology, 117. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-43978-4_147.

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Mehlhorn, Heinz. "Amoebicides." In Encyclopedia of Parasitology, 1. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27769-6_147-2.

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Conference papers on the topic "Amoebicide"

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Wardana, Fendi Yoga, Defi Kartika Sari, Myrna Adianti, Adita Ayu Permanasari, Lidya Tumewu, Tomoyoshi Nozaki, Aty Widyawaruyanti, and Achmad Fuad Hafid. "Amoebicidal Activities of Indonesian Medicinal Plants in Balikpapan, East Kalimantan." In Bromo Conference, Symposium on Natural Products and Biodiversity. SCITEPRESS - Science and Technology Publications, 2018. http://dx.doi.org/10.5220/0008357700770082.

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