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1

Pommier, S., and C. Prioul. "Amorçage et propagation de fissure en fond d’entaille dans le superalliage N18, sous sollicitation de fatigue-fluage à 650°C." Revue de Métallurgie 91, no. 9 (1994): 1343. http://dx.doi.org/10.1051/metal/199491091343.

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2

Hild, François, Stéphane Roux, Marie-Christine Baïetto, et al. "« Radioscopies » d’une fissure de fatigue." Instrumentation Mesure Métrologie 12, no. 1-2 (2012): 131–52. http://dx.doi.org/10.3166/i2m.12.1-2.131-152.

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3

Bogard, F., P. Lestriez, and Y. Q. Guo. "Numerical Modeling of Fatigue Damage and Fissure Propagation under Cyclic Loadings." International Journal of Damage Mechanics 17, no. 2 (2007): 173–87. http://dx.doi.org/10.1177/1056789508088961.

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4

Chen, Hong-kai, and Hong-mei Tang. "Method to calculate fatigue fracture life of control fissure in perilous rock." Applied Mathematics and Mechanics 28, no. 5 (2007): 643–49. http://dx.doi.org/10.1007/s10483-007-0509-1.

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5

Jendoubi, K., N. Ranganathan, and J. P. Baïlon. "Technique de mesurein situ du CTOD au bout d'une fissure de fatigue." Materials and Structures 24, no. 1 (1991): 24–31. http://dx.doi.org/10.1007/bf02472677.

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6

Coulon, A., B. Knosp, and H. Saisse. "Plastification et déformation en fond d’entaille lors de l’amorçage d’une fissure de fatigue." Matériaux & Techniques 74, no. 1-2 (1986): 9–15. http://dx.doi.org/10.1051/mattech/198674010009.

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7

Onwubuya, M. N., and K. A. Odior. "Deformation Contour Analysis in Elastic Plastic Fatigue Fissure using Local and Global Integral Approach." International Journal of Advanced Engineering Research and Science 7, no. 5 (2020): 233–40. http://dx.doi.org/10.22161/ijaers.75.28.

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8

Bouami, Driss, and Daniel De Vadder. "Fermeture et ouverture de fissure de fatigue : détection et mesure par une méthode ultrasonore." Matériaux & Techniques 74, no. 3-4 (1986): 81–84. http://dx.doi.org/10.1051/mattech/198674030081.

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9

Thevenet, D., C. Erny, J. Y. Cognard, and M. Korner. "Prévision de l’amorçage d’une fissure de fatigue dans des assemblages soudés pour applications navales." Matériaux & Techniques 98, no. 4 (2010): 279–86. http://dx.doi.org/10.1051/mattech/2010103.

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10

Sniezek, Lucjan, Ireneusz Szachogluchowicz, Janusz Torzewski, and Krzysztof Grzelak. "Fatigue Cracking of AA2519-Ti6Al4V Laminate Bonded by Explosion Welding." Solid State Phenomena 250 (April 2016): 182–90. http://dx.doi.org/10.4028/www.scientific.net/ssp.250.182.

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This paper presents test results of AA2519/TI6AL4V composite laminate structure and mechanical properties. The composite laminate was merged by explosive welding using a transition AA1050 alloy layer. The tested composite after formation was annealed, quenched in water and then aged to strengthen it. The heat treatment process was carried out in order to improve the physical and strength properties of the laminate. Weld endurance properties were determined through fatigue testing performed in constant total deformation amplitude (εac) conditions.The paper also describes the influence of test conditions on hysteresis loop shape, process of cyclic material strengthening and weakening, and fatigue life. Low cycle test results were approximated using a straight line with the following formula: σa = K'(εap)n which enables the K'fatigue strength coefficient, and the n' cyclic strengthening index to be determined. Test results also include fatigue fracture surface analysis. Distinctive fatigue fissure characteristics were investigated through studying fatigue fracture surface microstructure using a scanning electron microscope.
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11

Lafarie-Frenot, M. C., and C. Gasc. "Fermeture d'une fissure de fatigue, dans le vide : influence de la rugosité des surfaces rompues." Revue de Physique Appliquée 22, no. 6 (1987): 375–88. http://dx.doi.org/10.1051/rphysap:01987002206037500.

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12

Dewji, Hasnain R., James L. Drummond, Shahrbanoo Fadavi, and Indru Punwani. "Bond strength of Bis-GMA and glass ionomer pit and fissure sealants using cyclic fatigue." European Journal of Oral Sciences 106, no. 1 (1998): 594–99. http://dx.doi.org/10.1046/j.0909-8836.1998.eos106110.x.

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13

Abdelmoula, Radhi, Jean-Jacques Marigo, and Thibaut Weller. "Construction d'une loi de fatigue à partir d'un modèle de forces cohésives : cas d'une fissure en mode III." Comptes Rendus Mécanique 337, no. 1 (2009): 53–59. http://dx.doi.org/10.1016/j.crme.2008.12.001.

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14

Shamshiri Milani, Hourieh, Nezhat Shakeri, and Taha Asbaghi. "Application of Repeated Measures Method to Compare Physical Maternal Health Index in a Follow-up Study." Global Journal of Health Science 9, no. 3 (2016): 276. http://dx.doi.org/10.5539/gjhs.v9n3p276.

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<p>Maternal health is a concept indicating the health of mothers during pregnancy, childbirth and the post-partum period. Recent literature indicates that the maternal mortality rate in Iran is 23 per 100,000 live birth. For every death, 20 to 30 mothers suffer from chronic and acute illnesses arising from pregnancy and delivery; therefore, using a valid and reliable indicator will help researchers assess maternal health more precisely. In this longitudinal study, attempt has been made to compare mothers’ health status by using a subjective tool for evaluating the Physical-Maternal Health Index (P-MHI). The most common complaints made by mothers were headache, back pain, mastitis, nipple fissure, breast abscess, abdominal pain, pain in genitalia, constipation, hemorrhoids, anal fissure, urinary problems/Incontinence, fatigue, and dizziness/vertigo. The P-MHI is defined on the basis of these complaints scaling 0-100. The higher the index, the better the health status of mothers. It was administered by structured interviews with 743 participants before and during pregnancy, one week, two, four, and six months after childbirth (2010-2011). Post-natal mothers experience various problems, with back pain and fatigue being the most common. The P-MHI was at its lowest level in the first week after delivery (76 out of 100), followed by the second month (82 out of 100). The results showed that not only do mothers significantly lose their reproductive health after pregnancy, they don't attain their pre-pregnancy health status even six months after delivery (P<0.0005). The trend of the P-MHI identified when and what kind of health care is the most urgent need of post-natal mothers.</p>
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15

Lautrou, Nicolas, David Thévenet, and Jean-Yves Cognard. "Une méthode de calcul de la durée de vie à l'amorçage de fissure de fatigue dans un joint soudé en acier S355NL." Mécanique & Industries 8, no. 3 (2007): 207–15. http://dx.doi.org/10.1051/meca:2007040.

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16

JAVED, EJAZ AHMAD. "FAMILIAL DUANE’S SYNDROME." Professional Medical Journal 17, no. 03 (2010): 522–25. http://dx.doi.org/10.29309/tpmj/2010.17.03.2900.

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Objectives: To describe a family suffering from Duane’s Syndrome. Study Design: Case series studies. Setting: Diagnosis and Research department of Ophthalmology, Allied Hospital ,PMC, Faisalabad Period; Oct 2009 (One month).Presentation: A Gentle man , 65 years old , shopkeeper , resident of Jaranwala, Faisalabad, presented with his four children two male and two female with complaint of asymmetry of their unilateral eyes, since birth. There was no history of maternal intake of drugs, or smoking during pregnancy. There was no history of trauma or surgery. On examination the unaided vision of all the study cases was 6/6, 6/6.The cornea, conjunctiva , lens, iris, pupil, vitreous and retina of all the subjects was normal. The IOP of the all was also with in normal range. The ocular motility and lid fissure narrowing was noted in different ocular gazes. The lymph nodes and Thyroid gland examination was done. The Hiss screen test was done to quantifyindividual muscle action. The Levator function test, cover tests, papillary reactions, Slit Lamp Examination, Fundus examination were performed. The lids fatigue ability tests and strength of hands grip was estimated at the last.All cranial nerves were examined. Urine ,Blood and Thyroid tests were requested and documented. Results; The all the cases had lid fissure narrowing in one of their horizontal gazes. The all of them had under action of one of their horizontal muscles. So all the children had been proved to be suffering from unilateral Familial Duane’s Syndrome. In our clinical practice the Familial DS is rarely found None of the study patients showed amblyopia, diplopia, upshots or down shoots phenomenon. Similarly no associated systemic anomalies were seen.
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17

Perry, K., J. Johnson, R. Yeadon, and N. Fitzpatrick. "Headless self-compressing cannulated screw fixation for treatment of radial carpal bone fracture or fissure in dogs." Veterinary and Comparative Orthopaedics and Traumatology 23, no. 02 (2010): 84–101. http://dx.doi.org/10.3415/vcot-09-01-0006.

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Summary Objectives: To report the application and clinical outcome of the treatment of radial carpal bone fracture in five dogs using a variably-pitched, headless cannulated compression screw (Acutrak®). Methods: Arthroscopy was performed prior to surgical repair in three cases. In two cases, a fissure within the radial carpal bone was more clearly apparent when oblique indirect illumination was employed at arthrotomy. Following Acutrak® screw placement via arthrotomy, external coaptation was applied in all cases for a period of two weeks. Results: Five dogs were treated, of which four were Boxers, and one was a Labrador Retriever crossbreed. All dogs were lame prior to treatment. There was no history of trauma, and all dogs had soft tissue swelling on the dorsal aspect of the radiocarpal joint. In all cases the fissure or fracture line was oblique in orientation, extending disto-medially from the midpoint of the radiocarpal joint proximally to the level of the second carpal bone distally. All fractures treated demonstrated progressive radiographic healing, and all dogs were free of lameness at six weeks postoperatively, but two of the five fractures failed to reach complete radiographic union. All dogs remained lameness-free with mean follow-up of 12.5 months. Discussion: Acutrak® screws are headless devices which achieve compression, even in small bone fragments. Threads engage both the near and far fracture segments, leading to increased screw-bone contact which maximizes pull-out strength and may increase the fatigue strength of the screw. Clinical significance: Fixation of two-piece canine radial carpal-bone fractures with the Acutrak® screw proved a reliable alternative to conventional compression screw fixation, and may have benefits over alternatives attributable to screw design and application technique.
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18

Combrade, P., and M. Foucault. "Fatigue-corrosion de l'acier de cuve 16 MND 5 en milieu primaire de REP : rôle des phénomènes de dépassivation- repassivation en pointe de fissure." Revue de Métallurgie 89, no. 10 (1992): 915–18. http://dx.doi.org/10.1051/metal/199289100915.

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19

Ather, Hafiz Mughees, Arfan Mahmood, Affan Shahid, Mohammed Osama, and Mohammad Idrees Shani. "Epidemiological charactristics of acute hepatitis in tertiary care hospital." Professional Medical Journal 28, no. 7 (2021): 1039–43. http://dx.doi.org/10.29309/tpmj/2021.28.07.5153.

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Objective: To record the epidemiological, characteristics of Acute hepatitis patients. Study Design. Cross Sectional study. Setting: Government General Hospital Ghulam Muhammad Abad, Faisalabad. Period: March 2019 to 30th of September 2019. Material & Methods: A total of 92 patients included in the study. Patient’s epidemiological characteristics, symptoms and lab results were recorded during hospital stay. Categorical variables were analyzed using Chi-Square and Fissure Exact tests. P value of <0.05 was considered statistically significant. Results: 78% were male & 22% were female. Water source was 16% filtered water, 32% ground water & 52% was Government supplied water. Most common symptom was yellow sclera (100%), Dark urine (100%), Nausea, fatigue and anorexia (Each 87%), Vomiting (83%), Fever (73%), Right hypochondriac pain (70%), Body aches (66%) and headache was 61%. Among the risk factors other than water source, outside eating was present in 74% and tattooing was present in 5% while blood transfusion history and Ear/Nose piercing was 0%. All 92 patients discharged in stable condition (100%). Tests for determination of cause i.e HAV & HEV serology were ordered in each case. Conclusion: Young males were affected more commonly. Presentation of acute hepatitis varies in symptoms but mostly the disease is self-limiting and running a mild course without leading to liver failure. Most common risk factor was outside eating in unhygienic environment which should be avoided.
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20

Tivers, M. S., J. Grierson, and A. P. Moores. "Clinical assessment of a shaft screw for stabilization of the humeral condyle in dogs." Veterinary and Comparative Orthopaedics and Traumatology 27, no. 03 (2014): 179–85. http://dx.doi.org/10.3415/vcot-13-05-0063.

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SummaryObjective: To report the use of a 4.5 mm shaft screw for the management of humeral condylar fractures (HCF) and incomplete ossification of the humeral condyle (IOHC) in dogs, and to assess risk factors for complications.Methods: Dogs with HCF or IOHC that were managed with a 4.5 mm shaft screw with a minimum follow-up of six months from surgery were included. Data from the case records were used to identify risk factors for complications. Long-term follow-up was provided by an owner questionnaire and veterinary re-examination.Results: Forty-three elbows were treated in 40 dogs (14 IOHC, 29 HCF). Minor complications were seen in four cases (9%) and major complications in 10 cases (23%). There were no statistically significant risk factors for major complication. Infection resulted in shaft screw removal from three IOHC cases. Four of eight IOHC cases that had a lateral approach had a major complication compared with zero out of six dogs that had a medial approach, but this difference was not significant (p = 0.085). Nine of 12 IOHC cases and 20/23 HCF cases had excellent or good limb use at the time of long-term follow- up (median of 106 weeks, range 26–227 weeks). All fractures healed but IOHC fissure healing was inconsistent. Fatigue failure of shaft screws was not seen.Clinical significance: The use of shaft screws for the management of IOHC and HCF is associated with a relatively low rate of complications (compared to previous reports) and a good long-term outcome.
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21

Kaplan, Danielle, John B. O'Hara, Carolina Posada, and Kristin E. Slyne. "A-78 Interdisciplinary Consultation in a Case of Herpes Simplex Encephalitis with Unique Neuropsychiatric Symptoms." Archives of Clinical Neuropsychology 36, no. 6 (2021): 1121–22. http://dx.doi.org/10.1093/arclin/acab062.96.

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Abstract Objective Herpes simplex encephalitis (HSE) is a rare neurological condition (~2–4 per million) marked by brain inflammation caused by herpes simplex virus (HSV). HSE is associated with both cognitive and neuropsychiatric symptoms, particularly memory and executive dysfunction. We present the case of a 63-year-old, right-handed, St. Lucian female who completed serial neuropsychological evaluations (NPE). Method The patient presented with a six-day history (per collateral) of fever, confusion, and nausea. The patient denied cognitive changes. Magnetic Resonance Imaging (MRI) revealed leptomeningeal enhancement in the right sylvian fissure, multiple right temporal sulci, and inferior right frontal lobe (Figure 1). There was no indication of seizures. Cerebrospinal fluid analysis was positive for HSV-1. A two-week course of intravenous acyclovir was initiated on hospital day three. Results (Table 1). Initial NPE results (day five) revealed global cognitive impairment with sparing of auditory attention; exam was limited secondary to significant fatigue. Following completion of antivirals, subsequent NPE (day 17) revealed similar findings, despite improved alertness; left neglect (Figure 2) and significant anosagnosia (i.e., lack of disease awareness) and anosodiaphoria (i.e., indifference reaction to neurological deficits) were noted. Two-month outpatient follow-up NPE revealed marginal improvement in aspects of language and learning, but continued memory impairment, dense anosagnosia, and anosodiaphoria. Conclusion In this case, the patient presented with salient neuropsychiatric sequelae of HSE that have not been commonly associated with this condition in the extant literature. Her denial of cognitive symptoms may have initially confounded the differential diagnosis, emphasizing the importance of multi-specialty collaboration. Limitations of available normative data also complicated examination.
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22

Orlowski, Robert Z., Shadia Zaman, Sheeba K. Thomas, et al. "Phase II Study Of The c-MET Inhibitor ARQ 197 (Tivantinib) In Patients With Relapsed Or Relapsed/Refractory Multiple Myeloma (RRMM)." Blood 122, no. 21 (2013): 1953. http://dx.doi.org/10.1182/blood.v122.21.1953.1953.

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Abstract Background c-MET receptor tyrosine kinase (RTK) activity has been implicated in establishing the oncogenic phenotype across several human cancers with high levels of the activating c-MET ligand, hepatocyte growth factor (HGF). Malignant plasma cells secrete HGF-activator (HGFA), which converts HGF to its active form, and high HGF levels are correlated with a poor prognosis in multiple myeloma. Syndecan 1 (CD138) on malignant plasma cells binds HGF and potentiates interleukin-6-induced growth and migration. HGF stimulation of myeloma cells also activates autophosphorylation of c-MET and other critical downstream signaling pathways promoting oncogenesis. Finally, pre-clinical studies have shown that suppression of c-MET signaling with a number of small molecules, including ARQ 197, induced myeloma cell apoptosis. Tivantinib-mediated cytotoxic response was observed at concentrations of less than 5 µM, which are achievable in the clinic. These findings supported the hypothesis that suppression of the HGF/c-MET signaling axis could be a rational strategy against RRMM. Methods In this phase II study, the efficacy and safety of ARQ 197, a non-competitive and highly selective inhibitor of the c-MET RTK, was studied in patients with RRMM. Primary objectives were to determine the overall response rate (ORR) to single-agent tivantinib in patients who had received one to four prior lines of therapy, and to define the toxicities in this population. A Simon’s Minimax 2-stage design was used for the study. ARQ 197 was administered at a starting oral dose of 360 mg twice daily with meals for each day of every 4-week treatment cycle. This dose was selected from prior phase I investigations in solid tumors, and at this dose level, steady-state plasma levels of ARQ 197 were 7 µM. Treatment could continue providing that patients did not experience undue toxicities, or disease progression. Tivantinib is provided through the Cancer Therapy Evaluation Program (CTEP), and this study was supported by CTEP, as well as the MD Anderson Cancer Center SPORE in Multiple Myeloma. Results A total of 16 patients were enrolled and treated to date, including 9 men and 7 women, who had received a median of 1 prior line of therapy (range 1-3), including stem cell transplant in ten. The mean patient age was 66 (range 49-76), with ethnicity including 13 Caucasian Americans, 2 African Americans, and 1 Asian American. Patients have received a median of 3 cycles of therapy to date (1-11) with one patient continuing on study, and all were evaluable for toxicity, while 11 were evaluable for response based on having completed two treatment cycles. The most common adverse events (AEs) of any grade seen in at least 25% of patients and felt to be at least possibly drug related included fatigue or decreased neutrophils (94% each), pain (81%), myalgias (56%), diarrhea (38%), memory impairment, respiratory disorders, and rash (31% each), and hypertension (25%), and these were predominantly grade 1 or 2. Grade 3 or 4 AEs included neutropenia (31% and 25%, respectively), syncope, infection, pain (13% of each, all grade 3), and anal fissure, cough, fatigue, hypertension, and pulmonary embolism (6% each, all grade 3). Stable disease (SD) has been seen as the best response in 4/11 (36%) evaluable patients, which was maintained for up to 11 cycles, while the remaining patients showed evidence of disease progression. Conclusion Single-agent tivantinib has been well tolerated in patients with RRMM, and the ability to achieve stable disease in patients with previously progressing myeloma does support the possibility that targeting c-MET has some promise. Future studies with rationally designed combination regimens incorporating a c-MET inhibitor and other novel agents may better define the role of this class of drugs in our armamentarium against myeloma. Disclosures: Orlowski: Bristol-Myers Squibb: Honoraria, Membership on an entity’s Board of Directors or advisory committees, Research Funding; Celgene Corporation: Honoraria, Membership on an entity’s Board of Directors or advisory committees, Research Funding; Millennium: The Takeda Oncology Company: Honoraria, Membership on an entity’s Board of Directors or advisory committees, Research Funding; Onyx Pharmaceuticals: Honoraria, Membership on an entity’s Board of Directors or advisory committees, Research Funding; Resverlogix: Research Funding; Array Biopharma: Honoraria, Membership on an entity’s Board of Directors or advisory committees; Genentech: Honoraria, Membership on an entity’s Board of Directors or advisory committees; Merck: Membership on an entity’s Board of Directors or advisory committees. Thomas:Millenium: Research Funding; Novartis: Research Funding; Celgene: Research Funding; Immunomedics: Research Funding; Pharmacyclics: Membership on an entity’s Board of Directors or advisory committees; Onyx: Membership on an entity’s Board of Directors or advisory committees. Shah:Celgene: Consultancy, Research Funding; Array: Consultancy, Research Funding; Novartis: Consultancy, Research Funding; Millenium: Consultancy, Research Funding; Onyx: Consultancy, Research Funding.
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23

Dorkhom, Stephan Joseph, Shadia Zaman, Sheeba K. Thomas, et al. "Phase II Study of the c-Met Inhibitor ARQ 197 (Tivantinib) in Patients with Relapsed Multiple Myeloma." Blood 120, no. 21 (2012): 2976. http://dx.doi.org/10.1182/blood.v120.21.2976.2976.

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Abstract Abstract 2976 Background: c-Met receptor tyrosine kinase (RTK) activity has been implicated in establishing the oncogenic phenotype across several human cancers with high levels of the activating c-Met ligand, hepatocyte growth factor (HGF). Malignant plasma cells secrete HGF-activator (HGFA), which converts HGF to its active form, and high HGF levels are correlated with a poor prognosis in multiple myeloma (MM). Syndecan 1 (CD138) on malignant plasma cells binds HGF and potentiates interleukin-6-induced growth and migration. HGF stimulation of myeloma cells also activates autophosphorylation of c-Met and other critical downstream signaling pathways promoting oncogenesis. Finally, pre-clinical studies have shown that suppression of c-Met signaling with a number of small molecules, including ARQ 197, induced myeloma cell apoptosis. Tevantinib-mediated cytotoxic response was observed at concentrations of less than 5 μM, which are achievable in the clinic. These findings supported the hypothesis that suppression of the HGF/c-Met signaling axis could be a rational strategy against relapsed multiple myeloma. Methods: In this phase II study, the efficacy and safety of ARQ 197, a non-competitive and highly selective inhibitor of the c-Met RTK, is being studied in patients with relapsed multiple myeloma. Primary objectives were to determine the overall response rate (ORR) to single-agent tivantinib in patients with relapsed multiple myeloma who had received one to four prior lines of therapy, and to define the toxicities in this population. ARQ 197 was administered at a starting oral dose of 360 mg twice daily with meals for each day of every 4-week treatment cycle. This dose was selected from prior phase I investigations in solid tumors, and at this dose level, steady-state plasma level sof ARQ-197 were 7 μM. Treatment could continue providing that patients did not experience undue toxicities, or disease progression. Tivantinib is provided through the Cancer Therapy Evaluation Program (CTEP), and this study is supported by CTEP, as well as the M. D. Anderson Cancer Center SPORE in Multiple Myeloma. Results: A total of 10 patients have been enrolled and treated to date, all of whom were evaluable for toxicity, with 8 evaluable for response based on having completed two treatment cycles. Patients had received from 1–3 prior lines of therapy for their disease, and 7/10 (70%) had presented with International Staging System stage I disease at diagnosis. All patients on study had an ECOG performance status of 1 or better, and received a median of 3.5 cycles of tivantinib (range 1–7). The most common adverse events (AEs) of any grade seen in at least 30% of patients included diarrhea (30%), dizziness (30%), dry eyes (30%), shortness of breath (30%), memory change (30%), myalgias (40%), fatigue (60%), and neutropenia (60%). Serious AEs (SAEs) occurred in 2 patients, including one patient with grade 3 syncope, and another with grade 4 neutropenia and a grade 3 anal fissure. Stable disease (SD) has been seen as the best response in 5/7 (71%) evaluable patients, which was maintained for up to 7 cycles, while the remaining patients showed evidence of disease progression. Conclusion: Enrollment is continuing to this first study of any c-Met inhibitor in patients with relapsed multiple myeloma to better define the role of single-agent tivantinib in this setting. To date, tivantinib has been tolerated well, and some evidence of activity has been seen, with stable disease in 63% of patients, all of whom were progressing at the time of enrollment. Updated toxicity and efficacy data will be presented at the time of the Annual Meeting. Correlative studies are also underway with the goal of identifying potential predictive biomarkers. Disclosures: Off Label Use: Tivantinib is being evaluated for patients with relapsed myeloma, but is not yet approved in this setting.
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24

Bouvard, Jean-Luc, Jean-Louis Chaboche, Frédéric Feyel, and Franck Gallerneau. "Simulation numérique de la propagation de fissure dans les superalliages monocristallins." European Journal of Computational Mechanics, August 23, 2007, 845–63. http://dx.doi.org/10.13052/remn.16.845-863.

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In this study, a numerical method is developped to simulate fatigue crack growth. This method is based on a numerical coupled analysis using a cohesive zone modelling under cyclic loading in order to develop a coupled predictive approach of the crack growth. First, we present this damage law, then its validation by a convergence study of the solution with mesh size. We apply this model to the crack growth calculations in the case of a smooth specimen with a precracking made with a single crystal superalloy. Finally, we define the method to calibrate the cohesive zone model parameters on the base of experimental tests performed in pur fatigue regime.
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25

Tetikkurt, Cuneyt, Zeynep Ferhan Ozseker, and Fatma Gülsüm Karakaş. "Splenic artery aneurysm in Sjögren’s syndrome." Monaldi Archives for Chest Disease 89, no. 2 (2019). http://dx.doi.org/10.4081/monaldi.2019.1082.

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A 40-year-old female presented with cough, exertional dyspnea, abdominal pain with distention, fatigue, dry eyes and dry mouth. Past history revealed asthma. Physical examination was normal except for tachypnea. We found leukocytosis, azygos fissure on chest X-ray along with normal pulmonary function tests and arterial blood gases. Thorax computed tomography (CT) revealed bronchiectasis and ground glass opacities in both lungs. Abdominal CT demonstrated thrombosed proximal splenic artery aneurysm. Further diagnostic procedures were done and according to the positive Schirmer test and compatible histopathologic findings of the salivary gland, diagnosis of primary Sjögren’s syndrome was established. Splenic artery aneurysm is rare occurring in less than 1% of the population that usually appears as an incidental finding. This is the first case in literature that introduces Sjögren’s syndrome as a risk factor for splenic artery aneurysm. The silent presentation of the splenic artery aneurysm should previse the clinicians that such an occurrence may cause a significant diagnostic dilemma.
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26

Wolf de Goes, Caroline Marção, Patricia Stella Pucharelli Fontanini, Lia Lorena Pimentel, and Ana Elisabete Paganelli G. de Avila Jacintho. "ANÁLISE DA APLICAÇÃO DE CONCRETO COM ADIÇÃO DE MACROFIBRAS ESTRUTURAIS SINTÉTICAS E MICROFIBRAS DE VIDRO ANTI-CRACK AR EM PISOS." REEC - Revista Eletrônica de Engenharia Civil 12, no. 1 (2016). http://dx.doi.org/10.5216/reec.v12i1.37400.

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RESUMO: As fibras vêm sendo muito utilizadas para reforçar o concreto, e hoje, existe uma grande variedade delas, por exemplo, fibras de polipropileno, fibras sintéticas, fibras com baixo teor de carbono, e fibras de polietileno. O emprego das fibras nas misturas cimentícias promove diversas melhorias ao concreto armado, como, aumento da resistência à fadiga e ao impacto; tenacidade à flexão; aumento da capacidade de absorção de energia, que transferem tensões através de fissuras, fazendo com que reduza sua propagação e expansão; e maior ductilidade, pois em concretos não reforçados, após a primeira fissura, o concreto se torna deficiente. Nesta pesquisa foram apresentadas as principais vantagens da adição de macrofibras estruturais sintéticas e microfibras de vidro ao concreto em pisos para redução de fissuras. O presente trabalho tem o objetivo de apresentar um Estudo de Caso e propor dois novos traços de concreto com adição de macrofibras estruturais sintéticas e microfibras de vidro como reforço de pisos e um traço referência sem adição de fibras. Foram analisadas as resistências à compressão axial, diametral, tração na flexão, impacto e módulo de elasticidade, dos novos traços e do concreto utilizado no Estudo de Caso, bem como, foram apresentadas as vantagens e desvantagens dessa mistura em relação ao concreto convencional. ABSTRACT: The fibers have been widely used for reinforcing concrete, and today, there are a plenty of them, like, polypropylene fibers, synthetic fibers, fibers with low carbon content andpolyethylene fibers. The use of fibers in cementitious mixtures promotes several improvements to the concrete, as, increased resistance to fatigue and impact, flexural toughness, increased capacity of energy absorption, that transfer stresses through the cracks, reducing the propagation and expansion, and more ductility, because unreinforced concrete, after the first fissure, the concrete becomes disabled. This research will analyze the main advantages of the application of macro synthetic structural fibers and micro AR glass fibers to concrete floors to reduce cracks. This paper aims to present a case study and two new features have been proposed using macro synthetic structural fibers and micro AR glass fibers addition on reinforced concrete on floors and one feature without fibers. Resistance to axial compression, diametrical compression, flexural thoughness, impact resistance and elasticity module were analyzed of the new features and the concrete used at case study, as well as the advantages and disadvantages of this mixture comparing to conventional concrete.
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