Relevant bibliographies by topics / AMPA receptors. structure-activity relationship

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'AMPA receptors. structure-activity relationship'

Author: Grafiati
Published: 4 June 2021
Last updated: 3 February 2022

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Journal articles on the topic "AMPA receptors. structure-activity relationship"

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Moreno-Pedraza, Francy Johanna, Leonardo René Lareo, and Edgar Antonio Reyes-Montaño. "Estudio computacional de las relaciones evolutivas de los receptores ionotrópicos NMDA, AMPA y kainato en cuatro especies de primates." Universitas Scientiarum 15, no. 3 (2010): 183. http://dx.doi.org/10.11144/javeriana.sc15-3.csot.

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<p><strong></strong><strong>Objective.</strong> To identify the influence of changes on the secondary structure and evolutionary relationship of NMDA, AMPA and kainate receptors in <em>Homo sapiens</em>,<em> Pan troglodytes</em>, <em>Pongo pygmaeus</em> and <em>Macaca mulatta</em>. <strong>Materials and methods.</strong> We identified 91 sequences for NMDA, AMPA and kainate receptors and analyzed with software for predicting secondary structure, phosphorylation sites, multiple alignments, selection of pro
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Liao, Su-Qun, Guo-Qiang Hou, Xuan Pan, Cong-Shu Liao, and Dong-Feng Li. "The Gain Modulation by N-methyl-D-aspartate in the Projection Neurons of Robust Nucleus of the Arcopallium in Adult Zebra Finches." Neural Plasticity 2012 (2012): 1–7. http://dx.doi.org/10.1155/2012/931780.

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The song of zebra finch is stable in life after it was learned successfully. Vocal plasticity is thought to be a motor exploration that can support continuous learning and optimization of performance. The activity of RA, an important pre-motor nucleus in songbird’s brain, influences the song directly. This variability in adult birdsong is associated with the activity of NMDA receptors in LMAN-RA synapses, but the detailed mechanism is unclear. The control of gain refers to modulation of a neuron's responsiveness to input and is critically important for normal sensory, cognitive, and motor func
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De Sarro, G., F. Nava, G. Calapai, and A. De Sarro. "Effects of some excitatory amino acid antagonists and drugs enhancing gamma-aminobutyric acid neurotransmission on pefloxacin-induced seizures in DBA/2 mice." Antimicrobial Agents and Chemotherapy 41, no. 2 (1997): 427–34. http://dx.doi.org/10.1128/aac.41.2.427.

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The behavioral and convulsant effects of pefloxacin (PEFLO), a quinolone derivative, were studied after intraperitoneal (i.p.) administration to Dilute Brown Agouti DBA/2J (DBA/2) mice, a strain genetically susceptible to sound-induced seizures. The anticonvulsant effects of some excitatory amino acid (EAA) antagonists acting at N-methyl-D-aspartate (NMDA) or alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and kainate (KA) receptors and of some compounds enhancing gamma-aminobutyric acid (GABA)-ergic transmission against seizures induced by PEFLO were also evaluated. The presen
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Antrobus, Shane, Brandon Pressly, Atefeh Mousavi Nik, Heike Wulff, and Isaac N. Pessah. "Structure-Activity Relationship of Neuroactive Steroids, Midazolam, and Perampanel Toward Mitigating Tetramine-Triggered Activity in Murine Hippocampal Neuronal Networks." Toxicological Sciences 180, no. 2 (2021): 325–41. http://dx.doi.org/10.1093/toxsci/kfab007.

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Abstract Tetramethylenedisulfotetramine (tetramine or TETS), a potent convulsant, triggers abnormal electrical spike activity (ESA) and synchronous Ca2+ oscillation (SCO) patterns in cultured neuronal networks by blocking gamma-aminobutyric acid (GABAA) receptors. Murine hippocampal neuronal/glial cocultures develop extensive dendritic connectivity between glutamatergic and GABAergic inputs and display two distinct SCO patterns when imaged with the Ca2+ indicator Fluo-4: Low amplitude SCO events (LASE) and High amplitude SCO events (HASE) that are dependent on TTX-sensitive network electrical
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Kapsali, F., C. Tsopelas, I. Kamilaris, M. Dimitraka, and A. Sardis. "Glutamate and Depression." European Psychiatry 24, S1 (2009): 1. http://dx.doi.org/10.1016/s0924-9338(09)70883-1.

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Glutamate is the principal excitatory neurotransmitter in the cerebral cortex and it is implicated in the pathophysiology of depression and antidepressant activity.Aim:Aim of this study is to review recent studies and examine the physiology of glutamate and its receptors, pathophysiology of NMDA, effects of stress on glial cells and glutamate neurotransmission and explore the antidepressant properties of NMDA antagonists.Method:Review of recent pharmacological, imaging and genetic studies.Results:Increasing evidence supports a tight relationship between stress, the glutamatergic system and dep
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CROOK, JOANNA D., ORIN S. PACKER, and DENNIS M. DACEY. "A synaptic signature for ON- and OFF-center parasol ganglion cells of the primate retina." Visual Neuroscience 31, no. 1 (2013): 57–84. http://dx.doi.org/10.1017/s0952523813000461.

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AbstractIn the primate retina, parasol ganglion cells contribute to the primary visual pathway via the magnocellular division of the lateral geniculate nucleus, display ON and OFF concentric receptive field structure, nonlinear spatial summation, and high achromatic temporal–contrast sensitivity. Parasol cells may be homologous to the alpha-Y cells of nonprimate mammals where evidence suggests that N-methyl-D-aspartate (NMDA) receptor-mediated synaptic excitation as well as glycinergic disinhibition play critical roles in contrast sensitivity, acting asymmetrically in OFF- but not ON-pathways.
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Varga, Edina, Gábor Juhász, Zsolt Bozsó, Botond Penke, Lívia Fülöp, and Viktor Szegedi. "Abeta(1-42) Enhances Neuronal Excitability in the CA1 via NR2B Subunit-Containing NMDA Receptors." Neural Plasticity 2014 (2014): 1–12. http://dx.doi.org/10.1155/2014/584314.

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Neuronal hyperexcitability is a phenomenon associated with early Alzheimer’s disease. The underlying mechanism is considered to involve excessive activation of glutamate receptors; however, the exact molecular pathway remains to be determined. Extracellular recording from the CA1 of hippocampal slices is a long-standing standard for a range of studies both in basic research and in neuropharmacology. Evoked field potentials (fEPSPs) are regarded as the input, while spiking rate is regarded as the output of the neuronal network; however, the relationship between these two phenomena is not fully
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Li, Cheng-Shu, and David V. Smith. "Glutamate Receptor Antagonists Block Gustatory Afferent Input to the Nucleus of the Solitary Tract." Journal of Neurophysiology 77, no. 3 (1997): 1514–25. http://dx.doi.org/10.1152/jn.1997.77.3.1514.

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Li, Cheng-Shu and David V. Smith. Glutamate receptor antagonists block gustatory afferent input to the nucleus of the solitary tract. J. Neurophysiol. 77: 1514–1525, 1997. The effects of excitatory amino acid (EAA) receptor antagonists in blocking the synaptic transmission between gustatory fibers of the chorda tympani (CT) nerve and taste-responsive neurons within the nucleus of the solitary tract (NST) were examined electrophysiologically in urethan-anesthetized hamsters. Single neurons in the NST were recorded extracellularly and drugs were microinjected into the vicinity of the cell with t
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Larsen, Anja Probst, Pierre Francotte, Karla Frydenvang, et al. "Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure–Activity Relationship at AMPA Receptors." ACS Chemical Neuroscience 7, no. 3 (2016): 378–90. http://dx.doi.org/10.1021/acschemneuro.5b00318.

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Kim, Y. I., and S. H. Chandler. "NMDA-induced burst discharge in guinea pig trigeminal motoneurons in vitro." Journal of Neurophysiology 74, no. 1 (1995): 334–46. http://dx.doi.org/10.1152/jn.1995.74.1.334.

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1. The responses of guinea pig trigeminal motoneurons (TMNs) to N-methyl-D,L-aspartate (NMA) were studied using brain stem slice preparations and whole cell patch-clamp (n = 89) or conventional microelectrode (n = 22) recording techniques. The primary goals of this study were to determine whether N-methyl-D-aspartate (NMDA) receptor activation would produce spontaneous bursting activity in TMNs and, if so, the underlying mechanisms responsible for the generation of these bursts. 2. Bath-applied NMA (100-300 microM, n = 80) in standard perfusion medium elicited depolarization, increase in appar
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Dissertations / Theses on the topic "AMPA receptors. structure-activity relationship"

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Nahas, Roger I. "Synthesis and structure-activity relationship of a series of sigma receptor ligands." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/4840.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2007.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on February 26, 2008) Vita. Includes bibliographical references.
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Senthil, Vijayalakshmi. "Structure, activity and relationship studies of peptide and non-peptide analogs with secretin receptor : in search of agonist and/or antagonist." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/207206.

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Class B GPCRs are emerging target in drug research. Currently these receptors serve as drug targets for several drug discovery companies and more than 50 percent of the drugs in the market targets GPCRs. Secretin receptor is found to be expressed in various tissues. Secretin regulates many bodily functions from energy to water homeostasis through both central and peripheral system. Though it holds a history of 100 years, the major drawback is its structural insights. In evidence of its integrated role in physiology as a potential target, the lookout for a novel agonist and / or antagonist for
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Hall, Sara M. "Bradykinin Ligands and Receptors Involved in Neuropathic Pain." Diss., The University of Arizona, 2015. http://hdl.handle.net/10150/578606.

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Neuropathic pain is a prevalent disease with no effective, safe treatments and limited knowledge on the mechanisms involved. One target for neuropathic pain treatment may be the blockade of Dynorphin A (Dyn A). Dyn A is a unique endogenous ligand that possesses well-known neuroinhibitory effects via opioid receptors and neuroexcitatory effects that are mediated through the bradykinin 2 receptors (B2Rs). Extensive SAR was carried out to develop a ligand for the blockade of the excitatory actions of Dyn A at the B2R. A lead ligand was able to block Dyn A-induced hyperalgesia in naïve animals and
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Hislop, James Nicholas. "An investigation of the relationship between gonadotrophin-releasing hormone receptor structure, internalisation and signalling." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368565.

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Qiu, Fei-Hua. "Proto-oncogene c-kit : structure and relationship to the transmembrane receptor kinases /." Access full-text from WCMC, 1989. http://proquest.umi.com/pqdweb?did=744572251&sid=1&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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Meaney, Steve. "Studies on oxysterols : origins, properties and roles /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-635-9.

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Shi, Huaiqiu Galen. "Protein recognition of template imprinted polymer surfaces /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/8075.

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Ruda, Marcus. "Design and synthesis of steroid mimetic libraries using solid phase techniques /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-049-4/.

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Xing, Li. "Non-enveloped virus infection probed with host cellular molecules : a structural study /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-289-2.

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Abbas, Haider. "Expression of sigma receptors in human cancer cell lines and effects of novel sigma-2 ligands on their proliferation." Thesis, University of Wolverhampton, 2018. http://hdl.handle.net/2436/621768.

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Sigma receptors originally thought to be an opioid receptor is now categorized as a distinct class of receptor. There are two main subtypes, the sigma-1 receptor and an uncharacterised binding site, named the sigma-2 binding site. The presence of the sigma-2 binding site shows high correlation with proliferation of cells and is associated with cancer. I have categorized sigma-1 and sigma-2 binding sites in 11 human tumour cell lines. I have demonstrated that tumour cell lines from a range of tissues express both sigma-1 and sigma-2 binding sites. One exception is the MCF7 breast cancer cell li
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Books on the topic "AMPA receptors. structure-activity relationship"

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Robert, Rein, and Golombek Amram, eds. Computer-assisted modeling of receptor-ligand interactions: Theoretical aspects and applications to drug design : proceedings of the 1988 OHOLO Conference held in Eilat, Israel, April 24-28, 1988. Liss, 1989.

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William, Hutchens T., J.T. Baker Chemical Co., and University of California, Los Angeles., eds. Protein recognition of immobilized ligands: Proceedings of a J.T. Baker-UCLA Colloquium, held at Santa Fe, New Mexico, December 2-7, 1987. A.R. Liss, 1989.

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1948-, Henderson David, ed. Steroid receptors and antihormones. New York Academy of Sciences, 1995.

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(Editor), Thomas Schrader, and Andrew D. Hamilton (Editor), eds. Functional Synthetic Receptors. Wiley-VCH, 2005.

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Schrader, Thomas, and Andrew D. Hamilton. Functional Synthetic Receptors. Wiley-VCH Verlag GmbH, 2005.

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Schrader, Thomas, and Andrew D. Hamilton. Functional Synthetic Receptors. Wiley & Sons, Incorporated, John, 2006.

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Thomas, Schrader, and Hamilton Andrew D, eds. Functional synthetic receptors. Wiley-VCH, 2005.

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Jean-Marc, Kamenka, Domino Edward F. 1924-, and French-U.S. Seminar CNRS/NSF on Multiple Sigma and PCP Receptor Ligands: Mechanisms for Neuromodulation and Protection? (3rd : 1991 : La Grande Motte, France), eds. Multiple sigma and PCP receptor ligands: Mechanisms for neuromodulation and neuroprotection? NPP Books, 1992.

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Kamenka, J. M. Multiple Sigma and Phencyclidine Receptor Ligands: Mechanisms for Neuromodulation and Protection. Npp Books, 1992.

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Williams, Michael, 1947 Jan. 3-, Glennon Richard A. 1945-, Timmermans, P. B. M. W. M., American Society for Pharmacology and Experimental Therapeutics., and American Chemical Society. Division of Medicinal Chemistry., eds. Receptor pharmacology and function. Dekker, 1989.

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Book chapters on the topic "AMPA receptors. structure-activity relationship"

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Mörl, K., and A. G. Beck-Sickinger. "Structure-Activity Relationship of Peptide-Derived Ligands at NPY Receptors." In Neuropeptide Y and Related Peptides. Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-642-18764-3_16.

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Jin, G. Z., K. X. Huang, W. D. Le, and S. X. Xu. "Structure-Activity Relationship of Tetrahydroprotoberberines on Central Dopamine Receptors: (−)-Stepholidine—a New Antagonist of Dopamine Receptors." In Pharmacology and Functional Regulation of Dopaminergic Neurons. Palgrave Macmillan UK, 1988. http://dx.doi.org/10.1007/978-1-349-10047-7_7.

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Kimura, Sadao, Katsutoshi Goto, Yuka Shigematsu, Yoshiki Sugita, and Ichiro Kanazawa. "The Mammalian Tachykinins and Their Receptors: Structure-Activity Relationship of the Mammalian Tachykinins." In Neuroendocrine Molecular Biology. Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-5131-3_13.

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Ward, C. W., T. P. J. Garrett, N. M. McKern, L. G. Sparrow, and M. J. Frenkel. "Structural Relationships between Members of the Insulin Receptor Family." In Insulin & Related Proteins - Structure to Function and Pharmacology. Springer Netherlands, 2002. http://dx.doi.org/10.1007/0-306-47582-0_12.

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De Meyts, P., and J. Whittaker. "Structure-Function Relationships of Insulin and Insulin-Like Growth factor-I Receptor Binding." In Insulin & Related Proteins - Structure to Function and Pharmacology. Springer Netherlands, 2002. http://dx.doi.org/10.1007/0-306-47582-0_11.

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Pérodin, Jacqueline, Roger Bossé, Sylvain Gagnon, et al. "Structure-Activity Relationship of the Agonist-Antagonist Transition on the Type 1 Angiotensin II Receptor; the Search for Inverse Agonists." In Recent Advances in Cellular and Molecular Aspects of Angiotensin Receptors. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4899-1376-0_14.

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Cai, Minying, Paolo Grieco, Jonathan Wiens, Dev Trivedi, and Victor J. Hruby. "Structure-Activity Relationship Studies of New Cyclic MSH Analogues Using Cloned-Human Melanocortin Receptors Lead to Greater Selectivity and Inverse Agonists." In Peptides: The Wave of the Future. Springer Netherlands, 2001. http://dx.doi.org/10.1007/978-94-010-0464-0_416.

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Bachmair, F., R. Hoffmann, G. Daxenbichler, and Th Langew. "Studies on structure—Activity relationships of retinoic acid receptor ligands by means of molecular modeling." In Vitamins & Hormones. Elsevier, 2000. http://dx.doi.org/10.1016/s0083-6729(00)59007-4.

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Galigniana, Mario D., and G. Piwien Pilipuk. "Activation of the Ligand–Mineralocorticoid Receptor Functional Unit by Ancient, Classical, and Novel Ligands. Structure–Activity Relationship." In Vitamins & Hormones. Elsevier, 2004. http://dx.doi.org/10.1016/s0083-6729(04)69002-9.

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Deeb, Omar, Heidy Martínez-Pachecho, Guillermo Ramírez-Galicia, and Ramón Garduño-Juárez. "Application of Docking Methodologies in QSAR-Based Studies." In Pharmaceutical Sciences. IGI Global, 2017. http://dx.doi.org/10.4018/978-1-5225-1762-7.ch033.

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The computational strategies permeate all aspects of drug discovery such as virtual screening techniques. Virtual screening can be classified into ligand based and structure based methods. The ligand based method such as Quantitative Structure Activity Relationship (QSAR) is used when a set of active ligand compounds is recognized and slight or no structural information is available for the receptors. In structure based drug design, the most widespread method is molecular docking. It is widely accepted that drug activity is obtained through the molecular binding of one ligand to receptor. In their binding conformations, the molecules exhibit geometric and chemical complementarity, both of which are essential for successful drug activity. The molecular docking approach can be used to model the interaction between a small drug molecule and a protein, which allow us to characterize the performance of small molecules in the binding site of target proteins as well as to clarify fundamental biochemical processes.
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Conference papers on the topic "AMPA receptors. structure-activity relationship"

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Ali, Syed M., Chris Brassard, Audra Dalton, et al. "Abstract 3905: Synthesis and structure activity relationship of substituted N,6-diphenyl-5,6-dihydrobenzo[h]quinazolin-2-amine as inhibitors of fibroblast growth factor receptors (FGFR)." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-3905.

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Charon, M. H., L. Tranqui, A. Andrieux, G. Hudry-Clergeon, and G. Marguerie. "FIBRINOGEN BINDING TO ENDOTHELIAL CELLS AND INTERFERING PEPTIDES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644735.

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Fibrinogen interacts with platelets and endothelial cells via specific binding sites. While the platelet fibrinogen receptor has been identified and was found to be associated with GPIIb-IIIa, the binding site on endothelial cells has not been characterized yet. The platelet GPIIb-IIIa belongs to the newly identified cytoadhesin family which includes immunologicaly related receptors interacting with RGD containing proteins. A cytoadhesin has recently been described on endothelial cells and the possibility that fibrinogen might interact with this glycoprotein was examined. Peptides correspondin
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