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Dissertations / Theses on the topic 'AMPA receptors. structure-activity relationship'

Author: Grafiati

Published: 4 June 2021

Last updated: 3 February 2022

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1

Nahas, Roger I. "Synthesis and structure-activity relationship of a series of sigma receptor ligands." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/4840.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2007.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on February 26, 2008) Vita. Includes bibliographical references.

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2

Senthil, Vijayalakshmi. "Structure, activity and relationship studies of peptide and non-peptide analogs with secretin receptor : in search of agonist and/or antagonist." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/207206.

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Class B GPCRs are emerging target in drug research. Currently these receptors serve as drug targets for several drug discovery companies and more than 50 percent of the drugs in the market targets GPCRs. Secretin receptor is found to be expressed in various tissues. Secretin regulates many bodily functions from energy to water homeostasis through both central and peripheral system. Though it holds a history of 100 years, the major drawback is its structural insights. In evidence of its integrated role in physiology as a potential target, the lookout for a novel agonist and / or antagonist for

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3

Hall, Sara M. "Bradykinin Ligands and Receptors Involved in Neuropathic Pain." Diss., The University of Arizona, 2015. http://hdl.handle.net/10150/578606.

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Neuropathic pain is a prevalent disease with no effective, safe treatments and limited knowledge on the mechanisms involved. One target for neuropathic pain treatment may be the blockade of Dynorphin A (Dyn A). Dyn A is a unique endogenous ligand that possesses well-known neuroinhibitory effects via opioid receptors and neuroexcitatory effects that are mediated through the bradykinin 2 receptors (B2Rs). Extensive SAR was carried out to develop a ligand for the blockade of the excitatory actions of Dyn A at the B2R. A lead ligand was able to block Dyn A-induced hyperalgesia in naïve animals and

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4

Hislop, James Nicholas. "An investigation of the relationship between gonadotrophin-releasing hormone receptor structure, internalisation and signalling." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368565.

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5

Qiu, Fei-Hua. "Proto-oncogene c-kit : structure and relationship to the transmembrane receptor kinases /." Access full-text from WCMC, 1989. http://proquest.umi.com/pqdweb?did=744572251&sid=1&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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6

Meaney, Steve. "Studies on oxysterols : origins, properties and roles /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-635-9.

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7

Shi, Huaiqiu Galen. "Protein recognition of template imprinted polymer surfaces /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/8075.

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8

Ruda, Marcus. "Design and synthesis of steroid mimetic libraries using solid phase techniques /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-049-4/.

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9

Xing, Li. "Non-enveloped virus infection probed with host cellular molecules : a structural study /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-289-2.

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10

Abbas, Haider. "Expression of sigma receptors in human cancer cell lines and effects of novel sigma-2 ligands on their proliferation." Thesis, University of Wolverhampton, 2018. http://hdl.handle.net/2436/621768.

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Sigma receptors originally thought to be an opioid receptor is now categorized as a distinct class of receptor. There are two main subtypes, the sigma-1 receptor and an uncharacterised binding site, named the sigma-2 binding site. The presence of the sigma-2 binding site shows high correlation with proliferation of cells and is associated with cancer. I have categorized sigma-1 and sigma-2 binding sites in 11 human tumour cell lines. I have demonstrated that tumour cell lines from a range of tissues express both sigma-1 and sigma-2 binding sites. One exception is the MCF7 breast cancer cell li

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11

Lidén, Martin. "Molecular aspects of retinol uptake and activation /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-556-9/.

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12

Commare, Bruno. "Conception et synthèse de nouveaux agonistes de récepteurs métabotropiques du glutamate." Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05P621/document.

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Le glutamate est le principal neurotransmetteur excitateur du système nerveux central. Il est responsable de la majorité des transmissions synaptiques. En revanche, cet acide aminé naturel est aussi impliqué dans de nombreuses neuropathologies notamment en cas de surconcentration au niveau des synapses. Les récepteurs métabotropiques du glutamate, capables de moduler la transmission synaptique, constituent des cibles thérapeutiques prometteuses. Ces récepteurs sont divisés en trois groupes et notre laboratoire s’est focalisé sur ceux du groupe III et particulièrement le sous-type 4 qui présent

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13

Gianella-Borradori, Matteo Luca. "The identification & optimisation of endogenous signalling pathway modulators." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:4c87de5d-24a7-4998-8edb-917c3922aae1.

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<strong>Chapter 1</strong> Provides an overview of drug discovery with particular emphasis on library selection and hit identification methods using virtual based approaches. <strong>Chapter 2</strong> Gives an outline of the bone morphogenetic protein (BMP) signalling pathway and literature BMP pathway modulators. The association between the regulation of BMP pathway and cardiomyogenesis is also described. <strong>Chapter 3</strong> Describes the use of ligand based virtual screening to discover small molecule activators of the BMP signalling pathway. A robust cell based BMP responsive gene a

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14

Johannesson, Petra. "Synthesis of Aldehyde-Functionalized Building Blocks and Their Use for the Cyclization of Peptides : Applications to Angiotensin II." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5211-6/.

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15

Klose-Stier, Alexandra. "Synthese von neuartigen Sphingosin-Derivaten." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät, 2017. http://dx.doi.org/10.18452/17794.

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Sphingolipide sind essentielle Bestandteile der Plasmamembranen aller eukaryotischen Organismen und besitzen als Signalmoleküle regulierende Eigenschaften auf diverse zelluläre Prozesse. Hierbei spielen die G-Protein-gekoppelten S1P-Rezeptoren eine wichtige Rolle. Diese werden durch das natürliche Sphingosin-1-phosphat sowie die Sphingosin-Derivate FTY720 und cis-4-Methylsphingosin selektiv adressiert. Diese Arbeit beschreibt die Synthese von fünfzehn neuartigen Sphingosin-Derivaten mit potenziell neuen biologischen Eigenschaften. Hierfür wurde die Leitstruktur des natürlichen D-erythro-Sphing

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16

Davis, Jon Michael. "The modulation of polymorphonuclear neutrophil function by cytotoxic necrotizing factor type 1 -- expressing uropathogenic Escherichia coli /." Download the dissertation in PDF, 2005. http://www.lrc.usuhs.mil/dissertations/pdf/JDavis2005.pdf.

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17

Feve, Marie. "Utilisation d'une approche de chimie biologie intégrative dans la recherche de nouvelles molécules actives sur la prolifération et la différenciation des cellules souches cancéreuses." Phd thesis, Université de Strasbourg, 2012. http://tel.archives-ouvertes.fr/tel-00804357.

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Depuis l'émergence du concept de cellules souches cancéreuses (CSC), de telles cellules ont été isolées à partir de diverses tumeurs solides, dont les glioblastomes. Les CSC et les propriétés qui les caractérisent permettent de mieux comprendre l'hétérogénéité tumorale, ainsi que l'agressivité de certaines tumeurs et les récidives après traitement. Avec la mise en évidence des CSC, un nouveau paradigme est apparu dans le domaine de la thérapie anticancéreuse visant à cibler non seulement les cellules de la masse tumorale, mais également les CSC, plus résistantes aux chimio- et radiothérapies,

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18

Simms, Amy Nicole. "Examination of Neisseria gonorrhoeae opacity protein expression during experimental murine genital tract infection /." Download the dissertation in PDF, 2005. http://www.lrc.usuhs.mil/dissertations/pdf/Simms2005.pdf.

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19

López, Muñoz Laura. "Homology modeling and structural analysis of the antipsychotic drugs receptorome." Doctoral thesis, Universitat Pompeu Fabra, 2010. http://hdl.handle.net/10803/7228.

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Classically it was assumed that the compounds with therapeutic effect exert their action interacting with a single receptor. Nowadays it is widely recognized that the pharmacological effect of most drugs is more complex and involves a set of receptors, some associated to their positive effects and some others to the side effects and toxicity. Antipsychotic drugs are an example of effective compounds characterized by a complex pharmacological profile binding to several receptors (mainly G protein-coupled-receptors, GPCR). In this work we will present a detailed study of known antipsychotic drug

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20

"AMPA receptor activation and deactivation : a study of protein : ligand interactions of the GluR2 ligand binding core by x-ray crystallography /." Cph. : The Royal Danish School of Pharmacy, 2002. http://www.dfh.dk/phd/defences/andershogner.htm.

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21

Whittemore, Marilyn Schulte. "Synthesis, structure-activity relationships and photochemical studies of novel coumarins, dihydrophsoralens and dihydroangelicins as photo-activated agonists of the psoralen receptor /." Diss., 1998. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:9914440.

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