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Journal articles on the topic 'AMPA receptors. structure-activity relationship'

Author: Grafiati

Published: 4 June 2021

Last updated: 3 February 2022

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1

Moreno-Pedraza, Francy Johanna, Leonardo René Lareo, and Edgar Antonio Reyes-Montaño. "Estudio computacional de las relaciones evolutivas de los receptores ionotrópicos NMDA, AMPA y kainato en cuatro especies de primates." Universitas Scientiarum 15, no. 3 (2010): 183. http://dx.doi.org/10.11144/javeriana.sc15-3.csot.

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<p><strong></strong><strong>Objective.</strong> To identify the influence of changes on the secondary structure and evolutionary relationship of NMDA, AMPA and kainate receptors in <em>Homo sapiens</em>,<em> Pan troglodytes</em>, <em>Pongo pygmaeus</em> and <em>Macaca mulatta</em>. <strong>Materials and methods.</strong> We identified 91 sequences for NMDA, AMPA and kainate receptors and analyzed with software for predicting secondary structure, phosphorylation sites, multiple alignments, selection of pro

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Liao, Su-Qun, Guo-Qiang Hou, Xuan Pan, Cong-Shu Liao, and Dong-Feng Li. "The Gain Modulation by N-methyl-D-aspartate in the Projection Neurons of Robust Nucleus of the Arcopallium in Adult Zebra Finches." Neural Plasticity 2012 (2012): 1–7. http://dx.doi.org/10.1155/2012/931780.

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The song of zebra finch is stable in life after it was learned successfully. Vocal plasticity is thought to be a motor exploration that can support continuous learning and optimization of performance. The activity of RA, an important pre-motor nucleus in songbird’s brain, influences the song directly. This variability in adult birdsong is associated with the activity of NMDA receptors in LMAN-RA synapses, but the detailed mechanism is unclear. The control of gain refers to modulation of a neuron's responsiveness to input and is critically important for normal sensory, cognitive, and motor func

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3

De Sarro, G., F. Nava, G. Calapai, and A. De Sarro. "Effects of some excitatory amino acid antagonists and drugs enhancing gamma-aminobutyric acid neurotransmission on pefloxacin-induced seizures in DBA/2 mice." Antimicrobial Agents and Chemotherapy 41, no. 2 (1997): 427–34. http://dx.doi.org/10.1128/aac.41.2.427.

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The behavioral and convulsant effects of pefloxacin (PEFLO), a quinolone derivative, were studied after intraperitoneal (i.p.) administration to Dilute Brown Agouti DBA/2J (DBA/2) mice, a strain genetically susceptible to sound-induced seizures. The anticonvulsant effects of some excitatory amino acid (EAA) antagonists acting at N-methyl-D-aspartate (NMDA) or alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and kainate (KA) receptors and of some compounds enhancing gamma-aminobutyric acid (GABA)-ergic transmission against seizures induced by PEFLO were also evaluated. The presen

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Antrobus, Shane, Brandon Pressly, Atefeh Mousavi Nik, Heike Wulff, and Isaac N. Pessah. "Structure-Activity Relationship of Neuroactive Steroids, Midazolam, and Perampanel Toward Mitigating Tetramine-Triggered Activity in Murine Hippocampal Neuronal Networks." Toxicological Sciences 180, no. 2 (2021): 325–41. http://dx.doi.org/10.1093/toxsci/kfab007.

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Abstract Tetramethylenedisulfotetramine (tetramine or TETS), a potent convulsant, triggers abnormal electrical spike activity (ESA) and synchronous Ca2+ oscillation (SCO) patterns in cultured neuronal networks by blocking gamma-aminobutyric acid (GABAA) receptors. Murine hippocampal neuronal/glial cocultures develop extensive dendritic connectivity between glutamatergic and GABAergic inputs and display two distinct SCO patterns when imaged with the Ca2+ indicator Fluo-4: Low amplitude SCO events (LASE) and High amplitude SCO events (HASE) that are dependent on TTX-sensitive network electrical

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5

Kapsali, F., C. Tsopelas, I. Kamilaris, M. Dimitraka, and A. Sardis. "Glutamate and Depression." European Psychiatry 24, S1 (2009): 1. http://dx.doi.org/10.1016/s0924-9338(09)70883-1.

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Glutamate is the principal excitatory neurotransmitter in the cerebral cortex and it is implicated in the pathophysiology of depression and antidepressant activity.Aim:Aim of this study is to review recent studies and examine the physiology of glutamate and its receptors, pathophysiology of NMDA, effects of stress on glial cells and glutamate neurotransmission and explore the antidepressant properties of NMDA antagonists.Method:Review of recent pharmacological, imaging and genetic studies.Results:Increasing evidence supports a tight relationship between stress, the glutamatergic system and dep

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6

CROOK, JOANNA D., ORIN S. PACKER, and DENNIS M. DACEY. "A synaptic signature for ON- and OFF-center parasol ganglion cells of the primate retina." Visual Neuroscience 31, no. 1 (2013): 57–84. http://dx.doi.org/10.1017/s0952523813000461.

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AbstractIn the primate retina, parasol ganglion cells contribute to the primary visual pathway via the magnocellular division of the lateral geniculate nucleus, display ON and OFF concentric receptive field structure, nonlinear spatial summation, and high achromatic temporal–contrast sensitivity. Parasol cells may be homologous to the alpha-Y cells of nonprimate mammals where evidence suggests that N-methyl-D-aspartate (NMDA) receptor-mediated synaptic excitation as well as glycinergic disinhibition play critical roles in contrast sensitivity, acting asymmetrically in OFF- but not ON-pathways.

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7

Varga, Edina, Gábor Juhász, Zsolt Bozsó, Botond Penke, Lívia Fülöp, and Viktor Szegedi. "Abeta(1-42) Enhances Neuronal Excitability in the CA1 via NR2B Subunit-Containing NMDA Receptors." Neural Plasticity 2014 (2014): 1–12. http://dx.doi.org/10.1155/2014/584314.

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Neuronal hyperexcitability is a phenomenon associated with early Alzheimer’s disease. The underlying mechanism is considered to involve excessive activation of glutamate receptors; however, the exact molecular pathway remains to be determined. Extracellular recording from the CA1 of hippocampal slices is a long-standing standard for a range of studies both in basic research and in neuropharmacology. Evoked field potentials (fEPSPs) are regarded as the input, while spiking rate is regarded as the output of the neuronal network; however, the relationship between these two phenomena is not fully

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8

Li, Cheng-Shu, and David V. Smith. "Glutamate Receptor Antagonists Block Gustatory Afferent Input to the Nucleus of the Solitary Tract." Journal of Neurophysiology 77, no. 3 (1997): 1514–25. http://dx.doi.org/10.1152/jn.1997.77.3.1514.

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Li, Cheng-Shu and David V. Smith. Glutamate receptor antagonists block gustatory afferent input to the nucleus of the solitary tract. J. Neurophysiol. 77: 1514–1525, 1997. The effects of excitatory amino acid (EAA) receptor antagonists in blocking the synaptic transmission between gustatory fibers of the chorda tympani (CT) nerve and taste-responsive neurons within the nucleus of the solitary tract (NST) were examined electrophysiologically in urethan-anesthetized hamsters. Single neurons in the NST were recorded extracellularly and drugs were microinjected into the vicinity of the cell with t

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9

Larsen, Anja Probst, Pierre Francotte, Karla Frydenvang, et al. "Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure–Activity Relationship at AMPA Receptors." ACS Chemical Neuroscience 7, no. 3 (2016): 378–90. http://dx.doi.org/10.1021/acschemneuro.5b00318.

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10

Kim, Y. I., and S. H. Chandler. "NMDA-induced burst discharge in guinea pig trigeminal motoneurons in vitro." Journal of Neurophysiology 74, no. 1 (1995): 334–46. http://dx.doi.org/10.1152/jn.1995.74.1.334.

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1. The responses of guinea pig trigeminal motoneurons (TMNs) to N-methyl-D,L-aspartate (NMA) were studied using brain stem slice preparations and whole cell patch-clamp (n = 89) or conventional microelectrode (n = 22) recording techniques. The primary goals of this study were to determine whether N-methyl-D-aspartate (NMDA) receptor activation would produce spontaneous bursting activity in TMNs and, if so, the underlying mechanisms responsible for the generation of these bursts. 2. Bath-applied NMA (100-300 microM, n = 80) in standard perfusion medium elicited depolarization, increase in appar

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11

Zarrinmayeh, Hamideh, Eric Tromiczak, Dennis M. Zimmerman, et al. "A novel class of positive allosteric modulators of AMPA receptors: Design, synthesis, and structure–activity relationships of 3-biphenyl-4-yl-4-cyano-5-ethyl-1-methyl-1H-pyrrole-2-carboxylic acid, LY2059346." Bioorganic & Medicinal Chemistry Letters 16, no. 19 (2006): 5203–6. http://dx.doi.org/10.1016/j.bmcl.2006.07.012.

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12

Kumar, Sanjay S., and John R. Huguenard. "Properties of Excitatory Synaptic Connections Mediated by the Corpus Callosum in the Developing Rat Neocortex." Journal of Neurophysiology 86, no. 6 (2001): 2973–85. http://dx.doi.org/10.1152/jn.2001.86.6.2973.

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Despite the major role of excitatory cortico-cortical connections in mediating neocortical activities, little is known about these synapses at the cellular level. Here we have characterized the synaptic properties of long-range excitatory-to-excitatory contacts between visually identified layer V pyramidal neurons of agranular frontal cortex in callosally connected neocortical slices from postnatal day 13 to 21( P13–21) rats. Midline stimulation of the corpus callosum with a minimal stimulation paradigm evoked inward excitatory postsynaptic currents (EPSCs) with an averaged peak amplitude of 5

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13

Galas, M. C., M. F. Lignon, M. Rodriguez, et al. "Structure-activity relationship studies on cholecystokinin: analogues with partial agonist activity." American Journal of Physiology-Gastrointestinal and Liver Physiology 254, no. 2 (1988): G176—G182. http://dx.doi.org/10.1152/ajpgi.1988.254.2.g176.

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In the present study, hepta- and octapeptide analogues of the C-terminal part of cholecystokinin, modified on the C-terminal phenylalanine residue, were synthesized. CCK analogues were prepared in which the peptide bond between aspartic acid and phenylalanine had or had not been modified and were lacking the C-terminal primary amide function. These CCK derivatives were able to cause full stimulation of amylase release from rat pancreatic acini but without a decrease in amylase release at supramaximal concentrations. There was a close relationship between the abilities of these derivatives to s

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14

Jaracz, Stanislav, Koji Nakanishi, Anders A. Jensen, and Kristian Strømgaard. "Ginkgolides and Glycine Receptors: A Structure–Activity Relationship Study." Chemistry - A European Journal 10, no. 6 (2004): 1507–18. http://dx.doi.org/10.1002/chem.200305473.

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15

Nelson, Sharon H., and Odd S. Steinsland. "Dopamine receptors: Structure-activity relationship of d-tubocurarine analogues." European Journal of Pharmacology 108, no. 2 (1985): 209–12. http://dx.doi.org/10.1016/0014-2999(85)90729-0.

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16

Isokawa, Masako, Michel Levesque, Itzhak Fried, and Jerome Engel. "Glutamate Currents in Morphologically Identified Human Dentate Granule Cells in Temporal Lobe Epilepsy." Journal of Neurophysiology 77, no. 6 (1997): 3355–69. http://dx.doi.org/10.1152/jn.1997.77.6.3355.

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Isokawa, Masako, Michel Levesque, Itzhak Fried, and Jerome Engel, Jr. Glutamate currents in morphologically identified human dentate granule cells in temporal lobe epilepsy. J. Neurophysiol. 77: 3355–3369, 1997. Glutamate-receptor-mediated synaptic transmission was studied in morphologically identified hippocampal dentate granule cells (DGCs; n = 31) with the use of whole cell patch-clamp recording and intracellular injection of biocytin or Lucifer yellow in slices prepared from surgically removed medial temporal lobe specimens of epileptic patients (14 specimens from 14 patients). In the curr

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17

Ojima, Masanori. "Structure-Activity relationship for prostaglandins. An approach to prostaglandin receptors." Ensho 11, no. 3 (1991): 217–24. http://dx.doi.org/10.2492/jsir1981.11.217.

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18

Fouache, Allan, Nada Zabaiou, Cyrille De Joussineau, et al. "Flavonoids differentially modulate liver X receptors activity—Structure-function relationship analysis." Journal of Steroid Biochemistry and Molecular Biology 190 (June 2019): 173–82. http://dx.doi.org/10.1016/j.jsbmb.2019.03.028.

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19

Frączyk, Justyna, Agnieszka Mrozek, and Zbigniew J. Kamiński. "Structure–activity relationship in binding ligands to library of artificial receptors." Bioelectrochemistry 80, no. 1 (2010): 2–9. http://dx.doi.org/10.1016/j.bioelechem.2010.06.001.

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20

Narimatsu, Shogo, Yasuo Yoshioka, Tomohiro Morishige, et al. "Structure–activity relationship of T-cell receptors based on alanine scanning." Biochemical and Biophysical Research Communications 415, no. 4 (2011): 558–62. http://dx.doi.org/10.1016/j.bbrc.2011.10.092.

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21

Watkins, J. C. "Some chemical highlights in the development of excitatory amino acid pharmacology." Canadian Journal of Physiology and Pharmacology 69, no. 7 (1991): 1064–75. http://dx.doi.org/10.1139/y91-158.

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Important findings in the excitatory amino acid (EAA) field that have stemmed directly from work initiated in chemical laboratories are discussed from a historical point of view, showing how each has contributed to our present knowledge of EAA receptors. The groups of compounds discussed include simple analogues and derivatives of short-chain excitatory amino acids, longer-chain analogues, analogues containing ring structures essential to the acidic nature of the ω-terminal, and conformationally restricted agonists and antagonists. Recent interest has centred on antagonists for the N-methyl-D-

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22

Dolman, Nigel P., Julia C. A. More, Andrew Alt, et al. "Structure−Activity Relationship Studies on N3-Substituted Willardiine Derivatives Acting as AMPA or Kainate Receptor Antagonists." Journal of Medicinal Chemistry 49, no. 8 (2006): 2579–92. http://dx.doi.org/10.1021/jm051086f.

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23

Crittenden, Deborah L., Mary Chebib, and Meredith J. T. Jordan. "A quantitative structure–activity relationship investigation into agonist binding at GABAC receptors." Journal of Molecular Structure: THEOCHEM 755, no. 1-3 (2005): 81–89. http://dx.doi.org/10.1016/j.theochem.2005.07.029.

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24

Brown, Andrew J., Irene Castellano-Pellicena, Carl P. Haslam, Paula L. Nichols, and Simon J. Dowell. "Structure-Activity Relationship of the GPR55 Antagonist, CID16020046." Pharmacology 102, no. 5-6 (2018): 324–31. http://dx.doi.org/10.1159/000493490.

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Background/Aims: CID16020046 blocks the effect of the lipid lysophosphatidylinositol (LPI) at its receptor, GPR55. CID16020046 and another antagonist, ML193, have been used to investigate GPR55-mediated effects of LPI on cells, tissues, and in vivo. Here we describe the structure-activity relationship of CID16020046. Methods: Yeast or human cells were engineered to express GPR55 or control receptors. Cells were pretreated with a test agent before agonist challenge. Functional responses were quantified by yeast gene-reporter or calcium imaging. Results: Three substituents around the central pyr

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25

Zaidi, M., S. D. Brain, J. R. Tippins, et al. "Structure-activity relationship of human calcitonin-gene-related peptide." Biochemical Journal 269, no. 3 (1990): 775–80. http://dx.doi.org/10.1042/bj2690775.

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The calcitonin-calcitonin-gene-related peptide (CGRP) gene complex encodes a small family of peptides: calcitonin, CGRP and katacalcin. Calcitonin is a circulating hormone that prevents skeletal breakdown by inhibiting the resorption of bone by osteoclasts. CGRP, a potent vasodilator, is involved in normal regulation of blood flow. The calcitonins structurally resemble the CGRP peptides, and both are known to cross-react at each others' receptors. The present study was undertaken to examine the structural prerequisites for biological activity of the intact CGRP molecule. We therefore prepared

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Bourguignon, Jean-Jacques, Martine Schmitt, and Bruno Didier. "Design and structure-activity relationship analysis of ligands of gamma-hydroxybutyric acid receptors." Alcohol 20, no. 3 (2000): 227–36. http://dx.doi.org/10.1016/s0741-8329(99)00086-5.

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27

Kleczkowska, Patrycja, and Andrzej W. Lipkowski. "Neurotensin and neurotensin receptors: Characteristic, structure–activity relationship and pain modulation—A review." European Journal of Pharmacology 716, no. 1-3 (2013): 54–60. http://dx.doi.org/10.1016/j.ejphar.2013.03.004.

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28

Yip, Cecil C. "Cell-membrane hormone receptors: some perspectives on their structure and function relationship." Biochemistry and Cell Biology 66, no. 6 (1988): 549–56. http://dx.doi.org/10.1139/o88-065.

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There are three structural regions common to hormone receptors on the cell membrane: an external region containing the ligand-specific binding domain, a hydrophobic region transversing the membrane, and a cytoplasmic region involved in the expression of activity. The structural features of these regions are broadly reviewed in regard to their functional roles. It is suggested that the specificity of cellular response to hormonal stimulation lies not only in the binding of a specific ligand by the external domain but also in the cytoplasmic region of a receptor. The cytoplasmic region can eithe

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29

Catalani, Valeria, Michelle Botha, John Martin Corkery, et al. "The Psychonauts’ Benzodiazepines; Quantitative Structure-Activity Relationship (QSAR) Analysis and Docking Prediction of Their Biological Activity." Pharmaceuticals 14, no. 8 (2021): 720. http://dx.doi.org/10.3390/ph14080720.

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Designer benzodiazepines (DBZDs) represent a serious health concern and are increasingly reported in polydrug consumption-related fatalities. When new DBZDs are identified, very limited information is available on their pharmacodynamics. Here, computational models (i.e., quantitative structure-activity relationship/QSAR and Molecular Docking) were used to analyse DBZDs identified online by an automated web crawler (NPSfinder®) and to predict their possible activity/affinity on the gamma-aminobutyric acid A receptors (GABA-ARs). The computational software MOE was used to calculate 2D QSAR model

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30

Nekoei, Mehdia, Mahmoudb Salimi, Mohsenc Dolatabadi, and Majida Mohammadhosseini. "A quantitative structure-activity relationship study of tetrabutylphosphonium bromide analogs as muscarinic acetylcholine receptors." Journal of the Serbian Chemical Society 76, no. 8 (2011): 1117–27. http://dx.doi.org/10.2298/jsc101122102s.

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Quantitative structure-activity relationship (QSAR) of tetrabutylphosphonium bromide (TBPB) analogs as muscarinic acetylcholine receptors (mAChRs) was studied. A suitable set of molecular descriptors was calculated and stepwise multiple linear regression (SW-MLR) was employed to select those descriptors that resulted in the best fitted models. A MLR model with three selected descriptors was obtained. Furthermore, the MLR model was validated using the leave-one-out (LOO) and leave-group-out (LGO) crossvalidation, and the Y-randomization test. This model, with high statistical significance (R2 t

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31

Lang, Manja, and Annette Beck-Sickinger. "Structure-Activity Relationship Studies: Methods and Ligand Design for G-Protein Coupled Peptide Receptors." Current Protein & Peptide Science 7, no. 4 (2006): 335–53. http://dx.doi.org/10.2174/138920306778017981.

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32

Lüddens, Hartmut, Hans-J. Lang, and Esa R. Korpi. "Structure–activity relationship of furosemide-derived compounds as antagonists of cerebellum-specific GABAA receptors." European Journal of Pharmacology 344, no. 2-3 (1998): 269–77. http://dx.doi.org/10.1016/s0014-2999(97)01577-x.

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33

Chen, Xin, Hyunah Choo, Xi-Ping Huang, et al. "The First Structure–Activity Relationship Studies for Designer Receptors Exclusively Activated by Designer Drugs." ACS Chemical Neuroscience 6, no. 3 (2015): 476–84. http://dx.doi.org/10.1021/cn500325v.

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34

Poulsen, Mette H., Simon Lucas, Tinna B. Bach, et al. "Structure–Activity Relationship Studies of Argiotoxins: Selective and Potent Inhibitors of Ionotropic Glutamate Receptors." Journal of Medicinal Chemistry 56, no. 3 (2013): 1171–81. http://dx.doi.org/10.1021/jm301602d.

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35

Khlebnikov, Andrei I., Igor A. Schepetkin, and Mark T. Quinn. "Computational structure–activity relationship analysis of small-molecule agonists for human formyl peptide receptors." European Journal of Medicinal Chemistry 45, no. 11 (2010): 5406–19. http://dx.doi.org/10.1016/j.ejmech.2010.09.001.

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36

Taferner, Barbara, Wolfgang Schuehly, Antje Huefner, et al. "Modulation of GABAA-Receptors by Honokiol and Derivatives: Subtype Selectivity and Structure–Activity Relationship." Journal of Medicinal Chemistry 54, no. 15 (2011): 5349–61. http://dx.doi.org/10.1021/jm200186n.

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37

Rattan, Satish, and Raj K. Goyal. "Structure-activity relationship of subtypes of cholecystokinin receptors in the cat lower esophageal sphincter." Gastroenterology 90, no. 1 (1986): 94–102. http://dx.doi.org/10.1016/0016-5085(86)90080-6.

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38

Xiong, Xiao-Feng, Mette H. Poulsen, Rama A. Hussein, Niels G. Nørager, and Kristian Strømgaard. "Structure-Activity Relationship Study of Spider Polyamine Toxins as Inhibitors of Ionotropic Glutamate Receptors." ChemMedChem 9, no. 12 (2014): 2661–70. http://dx.doi.org/10.1002/cmdc.201402278.

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Mellor, I. R., T. J. Brier, F. Pluteanu, et al. "Modification of the philanthotoxin-343 polyamine moiety results in different structure-activity profiles at muscle nicotinic ACh, NMDA and AMPA receptors." Neuropharmacology 44, no. 1 (2003): 70–80. http://dx.doi.org/10.1016/s0028-3908(02)00336-2.

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Li, Yong, Gaston Calfa, Takafumi Inoue, Michelle D. Amaral, and Lucas Pozzo-Miller. "Activity-Dependent Release of Endogenous BDNF From Mossy Fibers Evokes a TRPC3 Current and Ca2+ Elevations in CA3 Pyramidal Neurons." Journal of Neurophysiology 103, no. 5 (2010): 2846–56. http://dx.doi.org/10.1152/jn.01140.2009.

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Multiple studies have demonstrated that brain-derived neurotrophic factor (BDNF) is a potent modulator of neuronal structure and function in the hippocampus. However, the majority of studies to date have relied on the application of recombinant BDNF. We herein report that endogenous BDNF, released via theta burst stimulation of mossy fibers (MF), elicits a slowly developing cationic current and intracellular Ca2+ elevations in CA3 pyramidal neurons with the same pharmacological profile of the transient receptor potential canonical 3 (TRPC3)-mediated IBDNF activated in CA1 neurons by brief loca

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41

Pigini, Maria, Wilma Quaglia, Francesco Gentili та ін. "Structure–activity relationship at α-adrenergic receptors within a series of imidazoline analogues of cirazoline". Bioorganic & Medicinal Chemistry 8, № 5 (2000): 883–88. http://dx.doi.org/10.1016/s0968-0896(00)00030-4.

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Evans, Jay T., Laura S. Bess, Sandra C. Mwakwari, et al. "Synthetic Toll-like Receptors 7 and 8 Agonists: Structure–Activity Relationship in the Oxoadenine Series." ACS Omega 4, no. 13 (2019): 15665–77. http://dx.doi.org/10.1021/acsomega.9b02138.

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Bodnar, Alice L., Luz A. Cortes-Burgos, Karen K. Cook та ін. "Discovery and Structure−Activity Relationship of Quinuclidine Benzamides as Agonists of α7 Nicotinic Acetylcholine Receptors". Journal of Medicinal Chemistry 48, № 4 (2005): 905–8. http://dx.doi.org/10.1021/jm049363q.

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Żydek, Grażyna, and Elżbieta Brzezińska. "Development and Validation of Quantitative Structure-Activity Relationship Models for Compounds Acting on Serotoninergic Receptors." Scientific World Journal 2012 (2012): 1–11. http://dx.doi.org/10.1100/2012/157950.

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A quantitative structure-activity relationship (QSAR) study has been made on 20 compounds with serotonin (5-HT) receptor affinity. Thin-layer chromatographic (TLC) data and physicochemical parameters were applied in this study. RP2 TLC 60F254plates (silanized) impregnated with solutions of propionic acid, ethylbenzene, 4-ethylphenol, and propionamide (used as analogues of the key receptor amino acids) and their mixtures (denoted as S1–S7 biochromatographic models) were used in two developing phases as a model of drug-5-HT receptor interaction. The semiempirical method AM1 (HyperChem v. 7.0 pro

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Arias, Hugo R., Dominik Feuerbach, Katarzyna M. Targowska-Duda, and Krzysztof Jozwiak. "Structure–activity relationship of ibogaine analogs interacting with nicotinic acetylcholine receptors in different conformational states." International Journal of Biochemistry & Cell Biology 43, no. 9 (2011): 1330–39. http://dx.doi.org/10.1016/j.biocel.2011.05.011.

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46

Veerasamy, Ravichandran, Anitha Roy, Rohini Karunakaran, and Harish Rajak. "Structure–Activity Relationship Analysis of Benzimidazoles as Emerging Anti-Inflammatory Agents: An Overview." Pharmaceuticals 14, no. 7 (2021): 663. http://dx.doi.org/10.3390/ph14070663.

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A significant number of the anti-inflammatory drugs currently in use are becoming obsolete. These are exceptionally hazardous for long-term use because of their possible unfavourable impacts. Subsequently, in the ebb-and-flow decade, analysts and researchers are engaged in developing new anti-inflammatory drugs, and many such agents are in the later phases of clinical trials. Molecules with heterocyclic nuclei are similar to various natural antecedents, thus acquiring immense consideration from scientific experts and researchers. The arguably most adaptable heterocyclic cores are benzimidazole

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Żydek, Grażyna, and Elżbieta Brzezińska. "NP TLC DATA IN STRUCTURE-ACTIVITY RELATIONSHIP STUDY OF SELECTED COMPOUNDS WITH ACTIVITY ON DOPAMINERGIC, SEROTONINERGIC, AND MUSCARINIC RECEPTORS." Journal of Liquid Chromatography & Related Technologies 35, no. 6 (2012): 834–53. http://dx.doi.org/10.1080/10826076.2011.613139.

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Cacciari, Barbara, Pamela Crepaldi, Chun Yan Cheng, et al. "Structure Activity Relationship of 4-Amino-2-thiopyrimidine Derivatives as Platelet Aggregation Inhibitors." Medicinal Chemistry 15, no. 8 (2019): 863–72. http://dx.doi.org/10.2174/1573406415666190208124534.

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Abstract:

Background: Platelet aggregation plays a pathogenic role in the development of arterial thrombi, which are responsible for common diseases caused by thrombotic arterial occlusion, such as myocardial infarction and stroke. Much efforts are directed toward developing platelet aggregation inhibitors that act through several mechanisms: The main antiplatelet family of COXinhibitors, phosphodiesterase inhibitors, and thrombin inhibitors. Recently, the important role in the platelet aggregation of adenosine diphosphate (ADP)-activated P2Y12 and P2Y1 receptors, Gprotein coupled receptors of the P2 pu

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Ojima, M., and T. Tokuhiro. "Hypothesis for the receptors of human blood platelet aggregation and its inhibition by structure-activity relationship." Prostaglandins, Leukotrienes and Essential Fatty Acids 47, no. 1 (1992): 69–76. http://dx.doi.org/10.1016/0952-3278(92)90188-o.

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Rárová, Lucie, Jana Steigerová, Miroslav Kvasnica, et al. "Structure activity relationship studies on cytotoxicity and the effects on steroid receptors of AB-functionalized cholestanes." Journal of Steroid Biochemistry and Molecular Biology 159 (May 2016): 154–69. http://dx.doi.org/10.1016/j.jsbmb.2016.03.017.

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