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Journal articles on the topic 'Amphibian skin secretions'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

CHEN, Tianbao, Susan FARRAGHER, Anthony J. BJOURSON, David F. ORR, Pingfan RAO, and Chris SHAW. "Granular gland transcriptomes in stimulated amphibian skin secretions." Biochemical Journal 371, no. 1 (2003): 125–30. http://dx.doi.org/10.1042/bj20021343.

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Amphibian defensive skin secretions are complex, species-specific cocktails of biologically active molecules, including many uncharacterized peptides. The study of such secretions for novel peptide discovery is time-limited, as amphibians are in rapid global decline. While secretion proteome analysis is non-lethal, transcriptome analysis has until now required killing of specimens prior to skin dissection for cDNA library construction. Here we present the discovery that polyadenylated mRNAs encoding dermal granular gland peptides are present in defensive skin secretions, stabilized by endogeno

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2

Indriani, Sylvia, Supatra Karnjanapratum, Nilesh Prakash Nirmal, and Sitthipong Nalinanon. "Amphibian Skin and Skin Secretion: An Exotic Source of Bioactive Peptides and Its Application." Foods 12, no. 6 (2023): 1282. http://dx.doi.org/10.3390/foods12061282.

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Amphibians have been consumed as an alternative protein source all around the world due to their delicacy. The skin of edible amphibians, particularly frogs and giant salamanders, always goes to waste without further utilization. However, these wastes can be utilized to extract protein and bioactive peptides (BPs). Various BPs have been extracted and reported for numerous biological activities such as antioxidant, antimicrobial, anticancer, antidiabetic, etc. The main BPs identified were brevinins, bombesins, dermaseptins, esculentins, magainin, temporins, tigerinins, and salamandrins. This re

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3

Nikolaieva, I. "AMPHIBIAN SKIN SECRETIONS: A POTENTIAL SOURCE OF PROTEOLYTIC ENZYMES." Biotechnologia Acta 11, no. 5 (2018): 42–48. http://dx.doi.org/10.15407/biotech11.05.042.

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4

Kyriachenko, Y., O. Oskyrko, I. Udovychenko, and T. Halenova. "Hemolytic activity of skin secretions of amphibians that inhabit the Ukraine territory." Bulletin of Taras Shevchenko National University of Kyiv. Series: Biology 80, no. 1 (2020): 6–10. http://dx.doi.org/10.17721/1728_2748.2020.80.6-10.

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Secretions derived from amphibian skin glands serve as a potential reservoir of various valuable active molecules. Currently, the multiple substances with diverse therapeutic activities among the components of glandular secretions of different species of amphibians have been found. It has been proven that they have antibacterial, antifungal, antiprotozoal, antidiabetic, antineoplastic, analgesic, and sleep-inducing properties. Taking this into consideration, to get the basic knowledge about the properties of the components of skin secretions of some Anura species that inhabit the territory of

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5

Cao, Xiaoqing, Jing Tang, Zhe Fu, et al. "Identification and Characterization of a Novel Gene-encoded Antioxidant Peptide from Odorous Frog Skin." Protein & Peptide Letters 26, no. 3 (2019): 160–69. http://dx.doi.org/10.2174/0929866525666181114153136.

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Background: Amphibian skin plays an essential role in protecting organisms from harmful external factors such as UV radiation. How amphibians protect themselves from reactive oxygen species following long-term sun exposure is an important and interesting question. Amphibian skins possess a novel antioxidant system composed of various Antioxidant Peptides (AOPs), which maintain redox homeostasis. However, only a few AOPs have been identified so far. Methods: Using combinational methods of peptidomics and genomics, we characterized a novel gene-encoded antioxidant peptide (herein named OA-VI12)

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6

Evans, Christine M., and Edmund D. Brodie. "Adhesive Strength of Amphibian Skin Secretions." Journal of Herpetology 28, no. 4 (1994): 499. http://dx.doi.org/10.2307/1564965.

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7

Udovychenko, I., D. Oliynyk, J. Dudkina, T. Halenova, and O. Savchuk. "Analysis of the common spadefoot toad (PELOBATES FUSCUS) skin secretions on the presence of the potential hemostasis system effectors." Bulletin of Taras Shevchenko National University of Kyiv. Series: Biology 77, no. 1 (2019): 38–44. http://dx.doi.org/10.17721/1728_2748.2019.77.38-44.

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Since nowadays the chemical synthesis of new bioactive compounds is a complicated and expensive procedure, alongside with the increased price for drugs based on synthetic biologically active compounds, scientists lay emphasize on natural sources as a promising raw material for various biologically active substances. Amphibian skin glands secretions are a powerful source of potential pharmacological agents. Currently their antimicrobial, antiviral, cardiotonic and antidiabetic activities have been studied in detail, although almost nothing is known about the effects of the tailless amphibians'

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8

Kwok, Hang Fai, Tianbao Chen, Craig Ivanyi, and Chris Shaw. "DNA in Amphibian and Reptile Venom Permits Access to Genomes without Specimen Sacrifice." Genomics Insights 1 (January 2008): GEI.S1039. http://dx.doi.org/10.4137/gei.s1039.

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Amphibian defensive skin secretions and reptile venoms are rich sources of bioactive peptides with potential pharmacological/pharmaceutical applications. As amphibian and reptile populations are in rapid global decline, our research group has been developing analytical methods that permit generation of robust molecular data from non-invasive skin secretion samples and venom samples. While previously we have demonstrated that parallel proteome and venom gland transcriptome analyses can be performed on such samples, here we report the presence of DNA that facilitates the more widely-used applica

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9

Ramsey, Jeremy P., Laura K. Reinert, Laura K. Harper, Douglas C. Woodhams, and Louise A. Rollins-Smith. "Immune Defenses against Batrachochytrium dendrobatidis, a Fungus Linked to Global Amphibian Declines, in the South African Clawed Frog, Xenopus laevis." Infection and Immunity 78, no. 9 (2010): 3981–92. http://dx.doi.org/10.1128/iai.00402-10.

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ABSTRACT Batrachochytrium dendrobatidis is a chytrid fungus that causes the lethal skin disease chytridiomycosis in amphibians. It is regarded as an emerging infectious disease affecting diverse amphibian populations in many parts of the world. Because there are few model amphibian species for immunological studies, little is known about immune defenses against B. dendrobatidis. We show here that the South African clawed frog, Xenopus laevis, is a suitable model for investigating immunity to this pathogen. After an experimental exposure, a mild infection developed over 20 to 30 days and declin

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10

Lin, Yan, Nan Hu, Haoyang He, et al. "A Hylarana latouchii Skin Secretion-Derived Novel Bombesin-Related Pentadecapeptide (Ranatensin-HLa) Evoke Myotropic Effects on the in vitro Rat Smooth Muscles." Toxins 11, no. 4 (2019): 204. http://dx.doi.org/10.3390/toxins11040204.

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Amphibians have developed successful defensive strategies for combating predators and invasive microorganisms encountered in their broad range of environments, which involve secretion of complex cocktails of noxious, toxic and diverse bioactive molecules from the skins. In recent years, amphibian skin secretions have been considered as an extraordinary warehouse for the discovery of therapeutic medicines. In this study, through bioactivity screening of the Hylarana latouchii skin secretion-derived fractions, a novel peptide belonging to ranatensin subfamily (ranatensin-HLa) was discovered, and

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11

Udovychenko, Iryna, Yuliia Dudkina, Denys Oliinyk, Oleksandra Oskyrko, Oleksii Marushchak, and Tetiana Halenova. "Amphibian skin glands secretions affect plasma coagulation tests." ScienceRise: Biological Science, no. 5(14) (November 27, 2018): 36–40. http://dx.doi.org/10.15587/2519-8025.2018.148075.

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12

Demori, Ilaria, Zeinab El Rashed, Viola Corradino, et al. "Peptides for Skin Protection and Healing in Amphibians." Molecules 24, no. 2 (2019): 347. http://dx.doi.org/10.3390/molecules24020347.

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Amphibian skin is not to be considered a mere tegument; it has a multitude of functions related to respiration, osmoregulation, and thermoregulation, thus allowing the individuals to survive and thrive in the terrestrial environment. Moreover, amphibian skin secretions are enriched with several peptides, which defend the skin from environmental and pathogenic insults and exert many other biological effects. In this work, the beneficial effects of amphibian skin peptides are reviewed, in particular their role in speeding up wound healing and in protection from oxidative stress and UV irradiatio

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13

Ramsey, Jeremy P., Laura K. Reinert, Laura K. Harper, Douglas C. Woodhams, and Louise A. Rollins-Smith. "Immune defenses against Batrachochytrium dendrobatidis, a fungus linked to global amphibian declines, in the South African clawed frog, Xenopus laevis." Infection and Immunity 78, no. 9 (2010): 3981–92. https://doi.org/10.5281/zenodo.13524186.

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(Uploaded by Plazi for the Bat Literature Project) Batrachochytrium dendrobatidis is a chytrid fungus that causes the lethal skin disease chytridiomycosis in amphibians. It is regarded as an emerging infectious disease affecting diverse amphibian populations in many parts of the world. Because there are few model amphibian species for immunological studies, little is known about immune defenses against B. dendrobatidis. We show here that the South African clawed frog, Xenopus laevis, is a suitable model for investigating immunity to this pathogen. After an experimental exposure, a mild infecti

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14

Ramsey, Jeremy P., Laura K. Reinert, Laura K. Harper, Douglas C. Woodhams, and Louise A. Rollins-Smith. "Immune defenses against Batrachochytrium dendrobatidis, a fungus linked to global amphibian declines, in the South African clawed frog, Xenopus laevis." Infection and Immunity 78, no. 9 (2010): 3981–92. https://doi.org/10.5281/zenodo.13524186.

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Abstract:

(Uploaded by Plazi for the Bat Literature Project) Batrachochytrium dendrobatidis is a chytrid fungus that causes the lethal skin disease chytridiomycosis in amphibians. It is regarded as an emerging infectious disease affecting diverse amphibian populations in many parts of the world. Because there are few model amphibian species for immunological studies, little is known about immune defenses against B. dendrobatidis. We show here that the South African clawed frog, Xenopus laevis, is a suitable model for investigating immunity to this pathogen. After an experimental exposure, a mild infecti

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15

Ramsey, Jeremy P., Laura K. Reinert, Laura K. Harper, Douglas C. Woodhams, and Louise A. Rollins-Smith. "Immune defenses against Batrachochytrium dendrobatidis, a fungus linked to global amphibian declines, in the South African clawed frog, Xenopus laevis." Infection and Immunity 78, no. 9 (2010): 3981–92. https://doi.org/10.5281/zenodo.13524186.

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Abstract:

(Uploaded by Plazi for the Bat Literature Project) Batrachochytrium dendrobatidis is a chytrid fungus that causes the lethal skin disease chytridiomycosis in amphibians. It is regarded as an emerging infectious disease affecting diverse amphibian populations in many parts of the world. Because there are few model amphibian species for immunological studies, little is known about immune defenses against B. dendrobatidis. We show here that the South African clawed frog, Xenopus laevis, is a suitable model for investigating immunity to this pathogen. After an experimental exposure, a mild infecti

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16

Ramsey, Jeremy P., Laura K. Reinert, Laura K. Harper, Douglas C. Woodhams, and Louise A. Rollins-Smith. "Immune defenses against Batrachochytrium dendrobatidis, a fungus linked to global amphibian declines, in the South African clawed frog, Xenopus laevis." Infection and Immunity 78, no. 9 (2010): 3981–92. https://doi.org/10.5281/zenodo.13524186.

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Abstract:

(Uploaded by Plazi for the Bat Literature Project) Batrachochytrium dendrobatidis is a chytrid fungus that causes the lethal skin disease chytridiomycosis in amphibians. It is regarded as an emerging infectious disease affecting diverse amphibian populations in many parts of the world. Because there are few model amphibian species for immunological studies, little is known about immune defenses against B. dendrobatidis. We show here that the South African clawed frog, Xenopus laevis, is a suitable model for investigating immunity to this pathogen. After an experimental exposure, a mild infecti

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17

Bai, Bing, Xiaojuan Hou, Lei Wang, et al. "Feleucins: Novel Bombinin Precursor-Encoded Nonapeptide Amides from the Skin Secretion ofBombina variegata." BioMed Research International 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/671362.

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The first amphibian skin antimicrobial peptide (AMP) to be identified was named bombinin, reflecting its origin from the skin of the European yellow-bellied toad (Bombina variegata). Bombinins and their related peptides, the bombinin Hs, were subsequently reported from other bombinid toads. Molecular cloning of bombinin-encoding cDNAs from skin found that bombinins and bombinin Hs were coencoded on the same precursor proteins. Here, we report the molecular cloning of two novel cDNAs from a skin secretion-derived cDNA library ofB. variegatawhose open-reading frames each encode a novel bombinin

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18

Oskyrko, S., J. Dudkina, T. Nikolaieva, T. Halenova, and O. Marushchak. "Variability and properties of host defense peptides from the skin secretions of anurans." Bulletin of Taras Shevchenko National University of Kyiv. Series: Biology 76, no. 2 (2018): 51–56. http://dx.doi.org/10.17721/1728_2748.2018.76.51-56.

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Cationic antimicrobial proteins are an important part of innate nonspecific immunity. It is the first defensive level, which is inherent in almost all living organisms. The main objective of such proteins is the destruction of dangerous microorganisms (fungi, bacteria, viruses, parasites etc.). The skin of amphibians is a rich source of these molecules, which are produced and stockpiled in skin glands, which are usually located on the dorsal side of the body. Basically, they are spread over the surface of the body or grouped in special morphological structures – parotids. Currently the host de

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19

Reshmy, V., V. Preeji, A. Parvin, K. Santhoshkumar, and S. George. "Molecular Cloning of a Novel Bradykinin-Related Peptide from the Skin of Indian Bronzed Frog Hylarana Temporalis." Genomics Insights 3 (January 2010): GEI.S5409. http://dx.doi.org/10.4137/gei.s5409.

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Bradykinin-related peptides (BRPs) constitute one of the most studied groups of bioactive peptides in amphibian skin secretions. The present study describes the successful isolation of a novel BRP (hylaranakinin TE) from the skin secretion of the Indian bronzed frog Hylarana temporalis. The deduced open reading frame consisted of 115 amino acid residues with a putative signal peptide of 22 amino acid residues, followed by a spacer region and mature peptide regions that encode for two BRPs: a canonical bradykinin R-9-R with a C-terminal extension of FVPASSL and Thr 6 -BK. The Thr 6 -BK reported

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20

Yang, Jie, Chengliang Tong, Junmei Qi, et al. "Engineering and Structural Insights of a Novel BBI-like Protease Inhibitor Livisin from the Frog Skin Secretion." Toxins 14, no. 4 (2022): 273. http://dx.doi.org/10.3390/toxins14040273.

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The Bowman–Birk protease inhibitor (BBI) family is a prototype group found mainly in plants, particularly grasses and legumes, which have been subjected to decades of study. Recently, the discovery of attenuated peptides containing the canonical Bowman–Birk protease inhibitory motif has been detected in the skin secretions of amphibians, mainly from Ranidae family members. The roles of these peptides in amphibian defense have been proposed to work cooperatively with antimicrobial peptides and reduce peptide degradation. A novel trypsin inhibitory peptide, named livisin, was found in the skin s

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21

Che, Qiaolin, Yu Zhou, Hailong Yang, Jianxu Li, Xueqing Xu, and Ren Lai. "A novel antimicrobial peptide from amphibian skin secretions of Odorrana grahami." Peptides 29, no. 4 (2008): 529–35. http://dx.doi.org/10.1016/j.peptides.2008.01.004.

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22

Xu, Xueqing, and Ren Lai. "The Chemistry and Biological Activities of Peptides from Amphibian Skin Secretions." Chemical Reviews 115, no. 4 (2015): 1760–846. http://dx.doi.org/10.1021/cr4006704.

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23

Hernández-Pérez, Jesús, Aida Serra, Siu Sze, Patricia Conway, Jørgen Schlundt, and Jorge Benavides. "Identification of Arenin, a Novel Kunitz-Like Polypeptide from the Skin Secretions of Dryophytes arenicolor." International Journal of Molecular Sciences 19, no. 11 (2018): 3644. http://dx.doi.org/10.3390/ijms19113644.

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Amphibian skin secretions are enriched with complex cocktails of bioactive molecules such as proteins, peptides, biogenic amines, alkaloids guanidine derivatives, steroids and other minor components spanning a wide spectrum of pharmacological actions exploited for centuries in folk medicine. This study presents evidence on the protein profile of the skin secretions of the canyon tree frog, Dryophytes arenicolor. At the same time, it presents the reverse-phase liquid chromatography isolation, mass spectrometry characterization and identification at mRNA level of a novel 58 amino acids Kunitz-li

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Xiao, Yao, Cunbao Liu, and Ren Lai. "Antimicrobial peptides from amphibians." BioMolecular Concepts 2, no. 1-2 (2011): 27–38. http://dx.doi.org/10.1515/bmc.2011.006.

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AbstractIncreased prevalence of multi-drug resistance in pathogens has encouraged researchers to focus on finding novel forms of anti-infective agents. Antimicrobial peptides (AMPs) found in animal secretions are components of host innate immune response and have survived eons of pathogen evolution. Thus, they are likely to be active against pathogens and even those that are resistant to conventional drugs. Many peptides have been isolated and shown to be effective against multi-drug resistant pathogens. More than 500 AMPs have been identified from amphibians. The abundance of AMPs in frog ski

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Shaw, Chris. "Venom-based medicines: Advancing drug discovery with reptile and amphibian venom peptides." Biochemist 31, no. 5 (2009): 34–37. http://dx.doi.org/10.1042/bio03105034.

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Amphibian skin has long been known by humans to possess intriguing biological properties and scientific examination of these secretions has revealed that their components possess a range of medical properties. In Japan and China, toad venom has been used as an expectorant, anti-haemorrhagic, diuretic and cardiac stimulant, and some peptides in the secretions of South American frogs and toads have antibiotic and anticancer properties. In fact, the pharmaceutical industry was built upon the realization of the healing and therapeutic potential of many lead compounds used in ethnic or traditional

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Bowie, John H., Kate L. Wegener, Brian C. S. Chia, et al. "Host Defence Antibacterial Peptides from Skin Secretions of Australian Amphibians. The Relationship Between Structure and Activity." Protein & Peptide Letters 6, no. 5 (1999): 259–69. http://dx.doi.org/10.2174/092986650605221117113359.

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Abstract: Peptides have been isolated and characterised from the secretions of skin glands of twenty five species of Australian amphibian. Many peptides are host defence agents, showing, for example, neuropeptide and/or antibacterial activity. This review describes the relationship between activity and structure of the antibacterial peptides, particularly the caerin and uperin groups of peptide from the genera Litoria and Uperoleia.

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Proaño-Bolaños, Carolina, Ailín Blasco-Zúñiga, José Rafael Almeida, et al. "Unravelling the Skin Secretion Peptides of the Gliding Leaf Frog, Agalychnis spurrelli (Hylidae)." Biomolecules 9, no. 11 (2019): 667. http://dx.doi.org/10.3390/biom9110667.

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Frog skin secretions contain medically-valuable molecules, which are useful for the discovery of new biopharmaceuticals. The peptide profile of the skin secretion of Agalychnis spurrelli has not been investigated; therefore, the structural and biological characterization of its compounds signify an inestimable opportunity to acquire new biologically-active chemical scaffolds. In this work, skin secretion from this amphibian was analysed by molecular cloning and tandem mass spectrometry. Although the extent of this work was not exhaustive, eleven skin secretion peptides belonging to five peptid

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Santana, Carlos José Correia, Ana Carolina Martins Magalhães, Agenor C. M. dos Santos Júnior, et al. "Figainin 1, a Novel Amphibian Skin Peptide with Antimicrobial and Antiproliferative Properties." Antibiotics 9, no. 9 (2020): 625. http://dx.doi.org/10.3390/antibiotics9090625.

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Amphibian skin secretions are abundant in bioactive compounds, especially antimicrobial peptides. These molecules are generally cationic and rich in hydrophobic amino acids, have an amphipathic structure and adopt an α-helical conformation when in contact with microorganisms membranes. In this work, we purified and characterized Figainin 1, a novel antimicrobial and antiproliferative peptide from the cutaneous secretion of the frog Boana raniceps. Figainin 1 is a cationic peptide with eighteen amino acid residues—rich in leucine and isoleucine, with an amidated C-terminus—and adopts an α-helic

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Zhou, Xiaowei, Jie Xu, Ruimin Zhong, et al. "Pharmacological Effects of a Novel Bradykinin-Related Peptide (RR-18) from the Skin Secretion of the Hejiang Frog (Ordorrana hejiangensis) on Smooth Muscle." Biomedicines 8, no. 7 (2020): 225. http://dx.doi.org/10.3390/biomedicines8070225.

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Bradykinin (BK) and bradykinin-related peptides (BRPs), which were identified from a diversity of amphibian skin secretions, exerted contractile and relaxing effects on non-vascular and vascular smooth muscle, respectively. Here, we report a novel bradykinin-related peptide with a molecular mass of 1890.2 Da, RVAGPDKPARISGLSPLR, which was isolated and identified from Ordorrana hejiangensis skin secretions, followed by a C-terminal extension sequence VAPQIV. The biosynthetic precursor-encoding cDNA was cloned by the “shotgun” cloning method, and the novel RR-18 was identified and structurally c

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30

Corbin, Connie. "Exploring Differing Host Cutaneous Microbiome and Immune Responses Contributing to Chytridiomycosis Susceptibility in Amphibians." McGill Science Undergraduate Research Journal 17, no. 1 (2022): 81–85. http://dx.doi.org/10.26443/msurj.v17i1.181.

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Chytridiomycosis is an emerging infectious disease caused by Batrachochytrium dendrobatidis, a fungal pathogen affecting the skin of amphibians. Chytridiomycosis is differentially affecting amphibian species and populations across the world, causing severe declines and extinctions. It is spread by contact or zoospores travelling in water sources. It is not yet fully understood why susceptibility is so variable. Understanding differing susceptibility is crucial for realising any successful conservation efforts. Multiple factors appear responsible for the differing susceptibility. The two factor

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Conlon, J. Michael, Milena Mechkarska, and Jérôme Leprince. "Peptidomic analysis in the discovery of therapeutically valuable peptides in amphibian skin secretions." Expert Review of Proteomics 16, no. 11-12 (2019): 897–908. http://dx.doi.org/10.1080/14789450.2019.1693894.

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Sciani, Juliana Mozer, Paulo Luiz de-Sá-Júnior, Adilson Kleber Ferreira, et al. "Cytotoxic and antiproliferative effects of crude amphibian skin secretions on breast tumor cells." Biomedicine & Preventive Nutrition 3, no. 1 (2013): 10–18. http://dx.doi.org/10.1016/j.bionut.2012.11.001.

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Wei, Xue-Song, Ling-Zhen Liu, Xian-Ling Bian, et al. "Protein composition of extracellular vesicles from skin secretions of the amphibian Bombina maxima." Zoological Research 43, no. 4 (2022): 687–90. http://dx.doi.org/10.24272/j.issn.2095-8137.2022.4.dwxyj202204023.

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34

Santana, Carlos José Correia, Ana Carolina Martins Magalhães, César Augusto Prías-Márquez, et al. "Biological Properties of a Novel Multifunctional Host Defense Peptide from the Skin Secretion of the Chaco Tree Frog, Boana raniceps." Biomolecules 10, no. 5 (2020): 790. http://dx.doi.org/10.3390/biom10050790.

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In recent years, the number of new antimicrobial drugs launched on the market has decreased considerably even though there has been an increase in the number of resistant microbial strains. Thus, antimicrobial resistance has become a serious public health problem. Amphibian skin secretions are a rich source of host defense peptides, which generally are cationic and hydrophobic molecules, with a broad-spectrum of activity. In this study, one novel multifunctional defense peptide was isolated from the skin secretion of the Chaco tree frog, Boana raniceps. Figainin 2 (1FLGAILKIGHALAKTVLPMVTNAFKPK

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CLARKE, B. T. "THE NATURAL HISTORY OF AMPHIBIAN SKIN SECRETIONS, THEIR NORMAL FUNCTIONING AND POTENTIAL MEDICAL APPLICATIONS." Biological Reviews 72, no. 3 (2007): 365–79. http://dx.doi.org/10.1111/j.1469-185x.1997.tb00018.x.

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CLARKE, B. T. "THE NATURAL HISTORY OF AMPHIBIAN SKIN SECRETIONS, THEIR NORMAL FUNCTIONING AND POTENTIAL MEDICAL APPLICATIONS." Biological Reviews of the Cambridge Philosophical Society 72, no. 3 (1997): 365–79. http://dx.doi.org/10.1017/s0006323197005045.

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37

Wang, Lei, Anita Smyth, Anders H. Johnsen, et al. "FMRFamide-related peptides (FaRPs): A new family of peptides from amphibian defensive skin secretions." Biochemical and Biophysical Research Communications 383, no. 3 (2009): 314–19. http://dx.doi.org/10.1016/j.bbrc.2009.04.002.

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38

Fu, Siqi, Canwei Du, Qijian Zhang, Jiayu Liu, Xushuang Zhang, and Meichun Deng. "A Novel Peptide from Polypedates megacephalus Promotes Wound Healing in Mice." Toxins 14, no. 11 (2022): 753. http://dx.doi.org/10.3390/toxins14110753.

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Amphibian skin contains wound-healing peptides, antimicrobial peptides, and insulin-releasing peptides, which give their skin a strong regeneration ability to adapt to a complex and harsh living environment. In the current research, a novel wound-healing promoting peptide, PM-7, was identified from the skin secretions of Polypedates megacephalus, which has an amino acid sequence of FLNWRRILFLKVVR and shares no structural similarity with any peptides described before. It displays the activity of promoting wound healing in mice. Moreover, PM-7 exhibits the function of enhancing proliferation and

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Marenah, L., PR Flatt, DF Orr, S. McClean, C. Shaw, and YH Abdel-Wahab. "Brevinin-1 and multiple insulin-releasing peptides in the skin of the frog Rana palustris." Journal of Endocrinology 181, no. 2 (2004): 347–54. http://dx.doi.org/10.1677/joe.0.1810347.

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Few studies have comprehensively examined amphibian granular gland secretions for novel insulinotropic peptides. This study involved isolation and characterisation of biologically active peptides from the skin secretions of Rana palustris frogs. Crude secretions obtained by mild electrical stimulation from the dorsal skin surface were purified by reversed-phase HPLC on a semipreparative Vydac C18 column, yielding 80 fractions. These fractions were assayed for insulin-releasing activity using glucose-responsive BRIN-BD11 cells. Acute 20 min incubations were performed in Krebs Ringer bicarbonate

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Liu, Naixin, Zhe Li, Buliang Meng, et al. "Accelerated Wound Healing Induced by a Novel Amphibian Peptide (OA-FF10)." Protein & Peptide Letters 26, no. 4 (2019): 261–70. http://dx.doi.org/10.2174/0929866526666190124144027.

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Background: Despite the continued development of modern medicine, chronic wounds are still a critical issue in clinical treatment, placing a great physiological, psychological, and financial burden on patients. Researchers have investigated many methods to solve this problem, with bioactive peptides gaining increasing attention due to their considerable advantages and diverse functions, as well as low cost, simple storage, and easy transportation. Methods: In this research, a novel peptide (named OA-FF10) was identified from the skin secretions of the odorous frog species Odorrana andersonii.

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Wang, Hui, Haoyang He, Xiaoling Chen, et al. "A Novel Antimicrobial Peptide (Kassinatuerin-3) Isolated from the Skin Secretion of the African Frog, Kassina senegalensis." Biology 9, no. 7 (2020): 148. http://dx.doi.org/10.3390/biology9070148.

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Amphibian skin secretions are remarkable sources of novel bioactive peptides. Among these, antimicrobial peptides have demonstrated an outstanding efficacy in killing microorganisms via a general membranolytic mechanism, which may offer the prospect of solving specific target-driven antibiotic resistance. Here, the discovery of a novel defensive peptide is described from the skin secretion of the African frog, Kassina senegalensis. Named kassinatuerin-3, it was identified through a combination of “shot-gun” cloning and MS/MS fragmentation sequencing. Subsequently, a synthetic replicate was sub

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Dong, Yanjing, Daning Shi, Yuan Ying, et al. "A Novel Kunitzin-Like Trypsin Inhibitor Isolated from Defensive Skin Secretion of Odorrana versabilis." Biomolecules 9, no. 7 (2019): 254. http://dx.doi.org/10.3390/biom9070254.

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Protease inhibitors that were identified from amphibian skin secretions with low molecular weights and potent inhibitory activity were thought to be potential candidates for novel peptide drugs. Here, a novel peptide with trypsin inhibitory activity was found in the skin secretion of the Chinese bamboo leaf odorous frog, Odorrana versabilis. Based on the sequence alignments of sequencing results, the novel peptide (ALKYPFRCKAAFC) was named as Kunitzin-OV. The synthetic replicate of Kunitzin-OV was subjected to a series of functional assays, and it exhibited a trypsin inhibitory activity with a

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Ramsey, Jeremy, Laura Reinert, Laura Harper, Douglas Woodhams, and Louise Rollins-Smith. "Innate and adaptive immune defenses against a fungus linked to global amphibian declines in the South African Clawed Frog, Xenopus laevis (43.24)." Journal of Immunology 184, no. 1_Supplement (2010): 43.24. http://dx.doi.org/10.4049/jimmunol.184.supp.43.24.

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Abstract Many amphibian species have suffered population declines due to an emerging infectious disease, chytridiomycosis, caused by the chytrid fungus, Batrachochytrium dendrobatidis (Bd). Little is known about immune defenses against this skin pathogen. Here we show that antimicrobial peptides in the skin mucus of the South African clawed frog, Xenopus laevis, inhibited Bd growth in vitro, and skin peptides secreted under natural conditions were within the range of concentrations required to inhibit Bd growth. Peptide secretion was induced by norepinephrine stimulation in a dose-dependent fa

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Ma, Jie, Yu Luo, Lilin Ge, et al. "Ranakinestatin-PPF from the Skin Secretion of the Fukien Gold-Striped Pond Frog,Pelophylax plancyi fukienensis: A Prototype of a Novel Class of BradykininB2Receptor Antagonist Peptide from Ranid Frogs." Scientific World Journal 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/564839.

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The defensive skin secretions of many amphibians are a rich source of bradykinins and bradykinin-related peptides (BRPs). Members of this peptide group are also common components of reptile and arthropod venoms due to their multiple biological functions that include induction of pain, effects on many smooth muscle types, and lowering systemic blood pressure. While most BRPs are bradykinin receptor agonists, some have curiously been found to be exquisite antagonists, such as the maximakinin gene-related peptide, kinestatin—a specific bradykinin B2-receptor antagonist from the skin of the giant

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Siano, Alvaro, Maria Humpola, Eliandre de Oliveira, et al. "Leptodactylus latrans Amphibian Skin Secretions as a Novel Source for the Isolation of Antibacterial Peptides." Molecules 23, no. 11 (2018): 2943. http://dx.doi.org/10.3390/molecules23112943.

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Amphibians´ skin produces a diverse array of antimicrobial peptides that play a crucial role as the first line of defense against microbial invasion. Despite the immense richness of wild amphibians in Argentina, current knowledge about the presence of peptides with antimicrobial properties is limited to a only few species. Here we used LC-MS-MS to identify antimicrobial peptides with masses ranging from 1000 to 4000 Da from samples of skin secretions of Leptodactylus latrans (Anura: Leptodactylidae). Three novel amino acid sequences were selected for chemical synthesis and further studies. The

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Wang, Ying, Xiaoqing Cao, Zhe Fu, et al. "Identification and characterization of a novel gene-encoded antioxidant peptide obtained from amphibian skin secretions." Natural Product Research 34, no. 6 (2018): 754–58. http://dx.doi.org/10.1080/14786419.2018.1499635.

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Bai, Bing, Yingqi Zhang, Hui Wang, et al. "Parallel Peptidome and Transcriptome Analyses of Amphibian Skin Secretions Using Archived Frozen Acid-Solvated Samples." Molecular Biotechnology 54, no. 2 (2012): 187–97. http://dx.doi.org/10.1007/s12033-012-9551-6.

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Brand, Guilherme D., José Roberto S. A. Leite, Luciano P. Silva, et al. "Dermaseptins fromPhyllomedusa oreadesandPhyllomedusa distincta." Journal of Biological Chemistry 277, no. 51 (2002): 49332–40. http://dx.doi.org/10.1074/jbc.m209289200.

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Amphibian skin secretions are known as a rich source of biologically active molecules, most of which are alkaloids, biogenic amines, and peptides. Dermaseptins are a class of antimicrobial peptides present in tree frogs of thePhyllomedusagenus. They are cationic molecules of 28–34 residues that permeabilize the membrane of Gram-positive and Gram-negative bacteria, yeasts, and filamentous fungi, showing little or no hemolytic activity. This work reports the isolation, molecular mass analysis, primary structure determination, biological activities, and potential therapeutic applications of an an

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Chianese, Annalisa, Carla Zannella, Alessandra Monti, et al. "The Broad-Spectrum Antiviral Potential of the Amphibian Peptide AR-23." International Journal of Molecular Sciences 23, no. 2 (2022): 883. http://dx.doi.org/10.3390/ijms23020883.

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Viral infections represent a serious threat to the world population and are becoming more frequent. The search and identification of broad-spectrum antiviral molecules is necessary to ensure new therapeutic options, since there is a limited availability of effective antiviral drugs able to eradicate viral infections, and consequently due to the increase of strains that are resistant to the most used drugs. Recently, several studies on antimicrobial peptides identified them as promising antiviral agents. In detail, amphibian skin secretions serve as a rich source of natural antimicrobial peptid

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Clarke, Emma, Kimberly Ange-van Heugten, Troy N. Tollefson, et al. "Comparison of Corticosterone Concentrations in Dermal Secretions and Urine in Free-Ranging Marine Toads (Rhinella marina) in Human Care." Veterinary Medicine International 2023 (September 19, 2023): 1–9. http://dx.doi.org/10.1155/2023/1467549.

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Corticosterone concentrations have been measured in amphibians by collecting blood or urine samples. However, blood sampling is invasive, and urine can be difficult to collect. A novel method of swabbing the skin of an amphibian has been utilized in numerous species but has not been verified in marine toads (Rhinella marina). This pilot study tested dermal swabs as a noninvasive method for collecting and measuring dermal corticosterone secretions. Swabs were used to collect dermal secretion samples from sixty-six free-ranging marine toads collected on Zoo Miami grounds. The subsequent day the

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