Relevant bibliographies by topics / Amplification Methods

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Amplification Methods'

Author: Grafiati
Published: 5 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "Amplification Methods"

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Carrino, John J., and Helen H. Lee. "Nucleic acid amplification methods." Journal of Microbiological Methods 23, no. 1 (1995): 3–20. http://dx.doi.org/10.1016/0167-7012(95)00024-f.

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Birkenmeyer, Larry G., and Isa K. Mushahwar. "DNA probe amplification methods." Journal of Virological Methods 35, no. 2 (1991): 117–26. http://dx.doi.org/10.1016/0166-0934(91)90127-l.

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Bonilla, Luis Fabián, Jamison H. Steidl, Grant T. Lindley, Alexei G. Tumarkin, and Ralph J. Archuleta. "Site amplification in the San Fernando Valley, California: Variability of site-effect estimation using the S-wave, coda, and H/V methods." Bulletin of the Seismological Society of America 87, no. 3 (1997): 710–30. http://dx.doi.org/10.1785/bssa0870030710.

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Abstract During the months that followed the 17 January 1994 M 6.7 Northridge, California, earthquake, portable digital seismic stations were deployed in the San Fernando basin to record aftershock data and estimate site-amplification factors. This study analyzes data, recorded on 31 three-component stations, from 38 aftershocks ranging from M 3.0 to M 5.1, and depths from 0.2 to 19 km. Site responses from the 31 stations are estimated from coda waves, S waves, and ratios of horizontal to vertical (H/V) recordings. For the coda and the S waves, site response is estimated using both direct spec
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Parshikov, B. Y., N. V. Prudnikov, E. A. Leonova, and N. A. Solovyov. "Femtosecond Laser Pulses Amplification Methods." Russian Journal of General Chemistry 94, no. 9 (2024): 2538–44. http://dx.doi.org/10.1134/s1070363224090317.

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Altwegg, M., and J. Verhoef. "Amplification methods in diagnostic microbiology." Journal of Microbiological Methods 23, no. 1 (1995): 1–2. http://dx.doi.org/10.1016/0167-7012(95)00020-l.

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Bodulev, O. L., and A. M. Soloviev. "HIGHLY SENSITIVE METHODS FOR MICRORNA DETECTION USING ISOTHERMAL METHODS FOR NUCLEIC ACIDS AMPLIFICATION." http://eng.biomos.ru/conference/articles.htm 1, no. 19 (2021): 244–46. http://dx.doi.org/10.37747/2312-640x-2021-19-244-246.

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This work will present the results of the development of two new highly sensitive heterogeneous methods for the determination of miRNA-141 and miRNA-39 using the isothermal circular strand-displacement amplification and the catalytic hairpin assembly methods for analyte amplification.
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Park, Jee-Woong. "Principles and Applications of Loop-Mediated Isothermal Amplification to Point-of-Care Tests." Biosensors 12, no. 10 (2022): 857. http://dx.doi.org/10.3390/bios12100857.

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For the identification of nucleic acids, which are important biomarkers of pathogen-mediated diseases and viruses, the gold standard for NA-based diagnostic applications is polymerase chain reaction (PCR). However, the requirements of PCR limit its application as a rapid point-of-care diagnostic technique. To address the challenges associated with regular PCR, many isothermal amplification methods have been developed to accurately detect NAs. Isothermal amplification methods enable NA amplification without changes in temperature with simple devices, as well as faster amplification times compar
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Padzil, Faiz, Abdul Razak Mariatulqabtiah, Wen Siang Tan, et al. "Loop-Mediated Isothermal Amplification (LAMP) as a Promising Point-of-Care Diagnostic Strategy in Avian Virus Research." Animals 12, no. 1 (2021): 76. http://dx.doi.org/10.3390/ani12010076.

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Over the years, development of molecular diagnostics has evolved significantly in the detection of pathogens within humans and their surroundings. Researchers have discovered new species and strains of viruses, while mitigating the viral infections that occur, owing to the accessibility of nucleic acid screening methods such as polymerase chain reaction (PCR), quantitative (real-time) polymerase chain reaction (qPCR) and reverse-transcription qPCR (RT-qPCR). While such molecular detection methods are widely utilized as the benchmark, the invention of isothermal amplifications has also emerged
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Zanoli, Laura Maria, and Giuseppe Spoto. "Isothermal Amplification Methods for the Detection of Nucleic Acids in Microfluidic Devices." Biosensors 3 (December 27, 2012): 18–43. https://doi.org/10.3390/bios3010018.

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Diagnostic tools for biomolecular detection need to fulfill specific requirements in terms of sensitivity, selectivity and high-throughput in order to widen their applicability and to minimize the cost of the assay. The nucleic acid amplification is a key step in DNA detection assays. It contributes to improving the assay sensitivity by enabling the detection of a limited number of target molecules. The use of microfluidic devices to miniaturize amplification protocols reduces the required sample volume and the analysis times and offers new possibilities for the process automation and integrat
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Wolcott, M. J. "Advances in nucleic acid-based detection methods." Clinical Microbiology Reviews 5, no. 4 (1992): 370–86. http://dx.doi.org/10.1128/cmr.5.4.370.

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Laboratory techniques based on nucleic acid methods have increased in popularity over the last decade with clinical microbiologists and other laboratory scientists who are concerned with the diagnosis of infectious agents. This increase in popularity is a result primarily of advances made in nucleic acid amplification and detection techniques. Polymerase chain reaction, the original nucleic acid amplification technique, changed the way many people viewed and used nucleic acid techniques in clinical settings. After the potential of polymerase chain reaction became apparent, other methods of nuc
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Dissertations / Theses on the topic "Amplification Methods"

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King, George. "Studies of amplification methods in immunohistochemistry." Thesis, University of Aberdeen, 2001. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU537963.

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The aim of this project was to compare and contrast the results of three related methodologies which are of particular relevance or potential within our department -. a manually performed streptAvidin Biotin Complex (sABC/ HRP) method which for many years has served as our 'standard' immunocytochemical method; an integrated semi-automated systems from DAKO based on the TechMate 500 immunostainer and the ChemMate reagent package;. a manually performed tyramide amplification method regarded as amongst the most sensitive immunocytochemical method currently available. Antigen retrieval investigati
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McElfish, Erin Marie. "Methods for parallel amplification of single DNA molecules." Diss., [La Jolla] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p1467961.

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Thesis (M.S.)--University of California, San Diego, 2009.<br>Title from first page of PDF file (viewed September 17, 2009). Available via ProQuest Digital Dissertations. Includes bibliographical references (p.76-77).
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Fernandez, Llenalia Garcia. "Statistical modelling of performance data for molecular amplification methods in diagnostic virology." Thesis, University of Abertay Dundee, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.650529.

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Nucleic Acid Technology (NAT), introduced in the late 90s, is a molecular amplification method that can be used for the diagnosis and management of patients with infectious diseases. NAT test results are obtained quicker and are quantified, providing great.er information than the positive/negative results available from traditional techniques. However, NATs arc technically demanding, susceptible to contamination and hence results from associated diagnostic tests may be inaccurate. External Quality Assessment (EQA) services are programmes developed to assess and advance the quality performance
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Thornley, John K. "Methods of application of piezoelectric multilayer actuators to high-speed clutching, using displacement amplification." Thesis, Loughborough University, 1993. https://dspace.lboro.ac.uk/2134/10851.

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The suitability of electromagnetic actuating devices for application to machines with ever more demanding response time specifications is discussed, with the proposal that piezoelectric actuator technology can produce practical devices with faster response times than solenoids, for example. This thesis discusses and validates the proposition that the performance of piezoelectric ceramic actuators makes them viable devices for inclusion in high-speed machine applications, where rapid clutching using two-state actuation is required. Further, techniques are devised and explored for the design and
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Civit, Pitarch Laia. "Development of electrochemical biosensors and solid-phase amplification methods for the detection of human papillomavirus genes." Doctoral thesis, Universitat Rovira i Virgili, 2012. http://hdl.handle.net/10803/84033.

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Un diagnòstic ràpid, precís i fiable és crucial per a la identificació d'una malaltia, com el càncer, on la detecció precoç pot millorar els resultants del tractament. El càncer de coll uterí és el tercer més comunament diagnosticat i la quarta causa de mort per càncer en les dones. La infecció persistent de virus del papil•loma humà d'alt risc (VPH) és la principal causa de càncer de coll uterí. Els biosensors electroquímics han rebut una important atenció a causa de les seves característiques. La seva compatibilitat amb tecnologies de microfabricació els fa atractius per al diagnòstic d'ADN
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Mignardi, Marco. "In situ Sequencing : Methods for spatially-resolved transcriptome analysis." Doctoral thesis, Stockholms universitet, Institutionen för biokemi och biofysik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-110057.

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It is well known that cells in tissues display a large heterogeneity in gene expression due to differences in cell lineage origin and variation in the local environment at different sites in the tissue, a heterogeneity that is difficult to study by analyzing bulk RNA extracts from tissue. Recently, genome-wide transcriptome analysis technologies have enabled the analysis of this variation with single-cell resolution. In order to link the heterogeneity observed at molecular level with the morphological context of tissues, new methods are needed which achieve an additional level of information,
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Wirta, Valtteri. "Mining the transcriptome - methods and applications." Doctoral thesis, Stockholm : School of Biotechnology, Royal Institute of Technology, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4115.

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Bernander, Sverker. "Detection and epidemiologic subtyping of Legionella pneumophila using DNA-based molecular methods /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-745-2.

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Nordén, Johan. "Assessment of methods for microRNA isolation, microRNA amplification, and development of a normalization strategy for sepsis biomarker research." Thesis, Högskolan i Skövde, Institutionen för biovetenskap, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-18442.

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Sepsis, defined by organ dysfunction caused by an adverse immune response of the host to an infection, comes with considerable cost in human lives and as a substantial burden financially. Significant upgrades have been made over the past two decades when diagnosing and treating sepsis but still with room for improvements. Early detection is a cornerstone in the fight against sepsis, and the focus on strengthening diagnostics is in the forefront of modern research. The implementation of biomarkers may be the path of progression in this objective. This study aimed at establishing procedural foun
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Tombolato, Fabio. "Theoretical and computational methods for soft matter problems." Doctoral thesis, Università degli studi di Padova, 2008. http://hdl.handle.net/11577/3425989.

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The present thesis deals with the development and implementation of models for problems in soft condensed matter, at the interface between biology and material science. In particular, two projects have been carried out. The first focuses on the molecular origin of chirality in liquid crystalline solutions of semiflexible polyelectrolytes like DNA, columnar aggregates of deoxyguanosine tetramers (G-wires) and filamentous becteriophages. The second project deals with the integration between theoretical and experimental methods for the study of membrane-proteins systems, starting from the analys
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Books on the topic "Amplification Methods"

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Rolfs, Arndt, Ines Weber-Rolfs, and Ulrich Finckh, eds. Methods in DNA Amplification. Springer US, 1994. http://dx.doi.org/10.1007/978-1-4615-2530-1.

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1959-, Rolfs Arndt, Weber-Rolfs Ines, Finckh Ulrich, and International PCR Symposium on Usage of PCR and Alternative Amplification Methods in Infectious and Genetic Diseases (2nd : 1993 : Berlin, Germany), eds. Methods in DNA amplification. Plenum Press, 1994.

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Mayer, Gaetan. Amplification methods for the immunolocalization of rare molecules in cells and tissues. Urban & Fischer, 2001.

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Mayer, Gaétan. Amplification methods for the immunolocalization of rare molecules in cells and tissue. Urban & Fischer, 2001.

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Dirk, Lassner, Pustowoit Barbara, Rolfs Arndt 1959-, and Augustusburg Conference of Advanced Science on Problems of Quantitation of Nucleic Acids by Amplification Techniques (1996), eds. Modern applications of DNA amplification techniques: Problems and new tools. Plenum Press, 1997.

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Osher, Stanley. Essentially non-oscillatory shock capturing methods applied to turbulence amplification in shock wave calculations. National Aeronautics and Space Administration, 1989.

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Scialpi, Angela, and Alessio Mengoni, eds. La PCR e le sue varianti. Firenze University Press, 2008. http://dx.doi.org/10.36253/978-88-6453-159-5.

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The book "La PCR e le sue varianti" is designed as a reference tool for those whose laboratory activities deal with methods based on nucleic acid amplification. The text provides the theoretical bases of the polymerase chain reaction (PCR) and its variants (e.g. RT-PCR, quantitative PCR, isothermic PCR) in a rapid and concise manner and describes the principal applications used for genetic identification and the study of genetic polymorphism, in the form of a protocol that can be easily consulted by the users.
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1949-, Potapov Alexander I., ed. Modulated waves: Theory and applications. The Johns Hopkins University Press, 1999.

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Farrell, Robert E. RNA methodologies: A laboratory guide for isolation and characterization. Academic Press, 1993.

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Farrell, Robert E. RNA methodologies: A laboratory guide for isolation and characterization. 2nd ed. Academic Press, 1998.

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Book chapters on the topic "Amplification Methods"

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Wang, Yun Wayne. "Signal Amplification Methods." In Clinical Virology Manual. ASM Press, 2016. http://dx.doi.org/10.1128/9781555819156.ch14.

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Sanno, Naoko, Akira Teramoto, and R. Yoshiyuki Osamura. "Tyramide Amplification in Immunohistochemistry." In Morphology Methods. Humana Press, 2001. https://doi.org/10.1007/978-1-59259-190-9_15.

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O’Leary, John. "The Polymerase Chain Reaction and Fixed Tissues." In Methods in DNA Amplification. Springer US, 1994. http://dx.doi.org/10.1007/978-1-4615-2530-1_1.

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Wiedmann, Martin, Wendy Wilson, John Czajka, Francis Barany, and Carl A. Batt. "Ligase-Mediated Detection Techniques." In Methods in DNA Amplification. Springer US, 1994. http://dx.doi.org/10.1007/978-1-4615-2530-1_10.

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van Gemen, B., T. Kievits, and P. F. Lens. "Qualitative and Quantitative Detection of Nucleic Acids of Infectious Agents by NASBA." In Methods in DNA Amplification. Springer US, 1994. http://dx.doi.org/10.1007/978-1-4615-2530-1_11.

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Kleiber, J., C. Kaletta, M. Hartl, C. Kessler, P. Kirch, and C. Majewski. "Application of NASBA to the Detection of Listeria Monocytogenes." In Methods in DNA Amplification. Springer US, 1994. http://dx.doi.org/10.1007/978-1-4615-2530-1_12.

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Wang, Ch H., and B. Flehmig. "Confirmation of Hepatitis C Virus Carrier State by Polymerase Chain Reaction in Cases with Nondiagnostic Serologies." In Methods in DNA Amplification. Springer US, 1994. http://dx.doi.org/10.1007/978-1-4615-2530-1_13.

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Lucotte, G., C. Mura, A. Aouizenate, T. Champenois, and J. Marchand. "Confirmation of Hepatitis C Virus Positive Seras by Polymerase Chain Reaction." In Methods in DNA Amplification. Springer US, 1994. http://dx.doi.org/10.1007/978-1-4615-2530-1_14.

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Kämmerer, U., B. Kunkel, and K. Korn. "Specific Detection and Rapid Identification of Human Enteroviruses by PCR Amplification." In Methods in DNA Amplification. Springer US, 1994. http://dx.doi.org/10.1007/978-1-4615-2530-1_15.

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Kessler, H. H., K. Pierer, D. Stünzner, and E. Marth. "Detection of Herpes Simplex Virus Using Polymerase Chain Reaction." In Methods in DNA Amplification. Springer US, 1994. http://dx.doi.org/10.1007/978-1-4615-2530-1_16.

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Conference papers on the topic "Amplification Methods"

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Jin, Jing, Houfeng Wang, Hao Zhang, Xiaoguang Li, and Zhijiang Guo. "DVD: Dynamic Contrastive Decoding for Knowledge Amplification in Multi-Document Question Answering." In Proceedings of the 2024 Conference on Empirical Methods in Natural Language Processing. Association for Computational Linguistics, 2024. http://dx.doi.org/10.18653/v1/2024.emnlp-main.266.

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Bao, Keqin, Jizhi Zhang, Yang Zhang, Xinyue Huo, Chong Chen, and Fuli Feng. "Decoding Matters: Addressing Amplification Bias and Homogeneity Issue in Recommendations for Large Language Models." In Proceedings of the 2024 Conference on Empirical Methods in Natural Language Processing. Association for Computational Linguistics, 2024. http://dx.doi.org/10.18653/v1/2024.emnlp-main.589.

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Kim, Hyeonwoo, Gyoungjin Gim, Yungi Kim, et al. "SAAS: Solving Ability Amplification Strategy for Enhanced Mathematical Reasoning in Large Language Models." In Proceedings of the 2024 Conference on Empirical Methods in Natural Language Processing: Industry Track. Association for Computational Linguistics, 2024. http://dx.doi.org/10.18653/v1/2024.emnlp-industry.15.

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Yu, Zhongjun, Boran Fan, and Xin Zhao. "Discrepancies of Amplification Factor Method in Stability Design of Tall Buildings." In IABSE Symposium, Tokyo 2025: Environmentally Friendly Technologies and Structures: Focusing on Sustainable Approaches. International Association for Bridge and Structural Engineering (IABSE), 2025. https://doi.org/10.2749/tokyo.2025.0453.

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&lt;p&gt;As building height increases, structural design constraint shifts from strength and displacement limitations to stability requirements. High-rise buildings experience growing displacements and internal forces under lateral and vertical loads, leading to instability that differs from buckling caused by gravity loads alone.Stability constraints, derived via the amplification factor method, depend on lateral stiffness and mass distribution. Using a simplified layer model, this paper compares Chinese and American codes on stability performance under lateral loads and validates displacemen
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Dubois, J. M. S., P. R. Roberge, and J. R. S. Giguere. "Eddy Current Sliding Probe Technology for the Detection of Corrosion in Multi-Layered Aircraft Structures." In CORROSION 2000. NACE International, 2000. https://doi.org/10.5006/c2000-00296.

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Abstract Corrosion in multi-layered structures cannot be effectively monitored by most Non-Destructive Testing methods. However, combining a multi-frequency eddy current technique with sliding probe technology, external amplification, digitization, and robotics provides the ability to quantify small amounts (3% of one plate thickness) of material loss in sub-layers not otherwise detectable using an industrial eddy current scope. The technique developed can be used in the field for aircraft inspection.
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Kobtsev, Sergey M. "Method of laser pulse amplification." In Novel Optical Systems, Methods, and Applications XXIV, edited by Cornelius F. Hahlweg and Joseph R. Mulley. SPIE, 2021. http://dx.doi.org/10.1117/12.2594935.

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Saitoh, Hidetaka, Takashi Soga, Shinji Kubo, Syuichi Sanki, and Morihisa Hoga. "Development methods for chemical amplification resist." In Photomask Japan '98 Symposium on Photomask and X-Ray Mask Technology V, edited by Naoaki Aizaki. SPIE, 1998. http://dx.doi.org/10.1117/12.328818.

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Chang, Shaojie, Zhenhua Wu, Diwei Liu, Renbin Zhong, and Min Hu. "Study of electron beam harmonic amplification methods." In 2023 24th International Vacuum Electronics Conference (IVEC). IEEE, 2023. http://dx.doi.org/10.1109/ivec56627.2023.10157811.

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Alexander, Akopov, and Lerer Alexander. "Raman scattering amplification parameters study in photonic crystals." In 2014 International Conference on Mathematical Methods in Electromagnetic Theory (MMET). IEEE, 2014. http://dx.doi.org/10.1109/mmet.2014.6928698.

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Moghimi, Saed, and Sinan Akkar. "EFFECT OF MAJOR SEISMOLOGICAL PARAMETERS ON DIRECTIVITY DOMINANT SPECTRAL AMPLIFICATION." In 6th International Conference on Computational Methods in Structural Dynamics and Earthquake Engineering Methods in Structural Dynamics and Earthquake Engineering. Institute of Structural Analysis and Antiseismic Research School of Civil Engineering National Technical University of Athens (NTUA) Greece, 2017. http://dx.doi.org/10.7712/120117.5741.18397.

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Reports on the topic "Amplification Methods"

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Levisohn, Sharon, Maricarmen Garcia, David Yogev, and Stanley Kleven. Targeted Molecular Typing of Pathogenic Avian Mycoplasmas. United States Department of Agriculture, 2006. http://dx.doi.org/10.32747/2006.7695853.bard.

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Intraspecies identification (DNA "fingerprinting") of pathogenic avian mycoplasmas is a powerful tool for epidemiological studies and monitoring strain identity. However the only widely method available for Mycoplasma gallisepticum (MG) and M. synoviae (MS)wasrandom amplified polymorphic DNA (RAPD). This project aimed to develop alternative and supplementary typing methods that will overcome the major constraints of RAPD, such as the need for isolation of the organism in pure culture and the lack of reproducibility intrinsic in the method. Our strategy focussed on recognition of molecular mark
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Radvand, Tina, and Alireza Talebpour. A Quantum Optimization Algorithm for Optimal Electric Vehicle Charging Station Placement for Intercity Trips. Illinois Center for Transportation, 2024. https://doi.org/10.36501/0197-9191/24-028.

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Electric vehicles (EVs) play a significant role in enhancing the sustainability of transportation systems. However, their widespread adoption is hindered by inadequate public charging infrastructure, particularly to support long-distance travel. Identifying optimal charging station locations in large transportation networks presents a well-known NP-hard combinatorial optimization problem, as the search space grows exponentially with the number of potential charging station locations. This report introduces a quantum search-based optimization algorithm designed to enhance the efficiency of solv
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Hajdini, Ina. Mis-specified Forecasts and Myopia in an Estimated New Keynesian Model. Federal Reserve Bank of Cleveland, 2023. http://dx.doi.org/10.26509/frbc-wp-202203r.

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The paper considers a New Keynesian framework in which agents form expectations based on a combination of autoregressive mis-specified forecasts and myopia. The proposed expectations formation process is shown to be consistent with all three empirical facts on consensus inflation forecasts. However, while mis-specified forecasts can be both sufficient and necessary to match all three facts, myopia alone is neither. The paper then derives the general equilibrium solution consistent with the proposed expectations formation process and estimates the model with likelihood-based Bayesian methods, y
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Mojidra, Rushil, and Keri Ryan. Influence of Vertical Ground Motion on Bridges Isolated with Spherical Sliding Bearings. Pacific Earthquake Engineering Research Center, University of California, Berkeley, CA, 2019. http://dx.doi.org/10.55461/rynq3624.

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The motivation for this project developed from testing of a full scale building isolated with triple friction pendulum bearings on the E-defense shake table in Japan. The test demonstrated experimentally that the vertical component of ground motion can amplify both the base shear and the story acceleration in the isolated building. Vertical shaking introduced high-frequency variation in the axial force of the bearings, and, consequently, a high-frequency component in the bearing lateral force, which excited higher structural modes in the building. Since vertical bridges are flexible in the ver
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Schöner, Wolfgang, Jorrit van der Schot, Peter Schweitzer, Sophie Elixhauser, and Anna Burdenski. Snow to Rain: From phase transition of precipitation to changing local livelihoods, emotions and affects in East Greenland. Verlag der Österreichischen Akademie der Wissenschaften, 2023. http://dx.doi.org/10.1553/ess-snow2rain.

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Snow2Rain investigated the impacts and perception of climate change in East Greenland through a holistic approach that includes natural science methods of time series analysis and statistical climatology on the one hand, and social science approaches of social anthropology on the other. In addition, this interdisciplinary approach was based in a transdisciplinary framework by involving the local people in Tasiilaq (East Greenland) and their knowledge. Based on the intention to study the effects of climate close to the everyday life of the locals, snow was chosen as one such interdisciplinary i
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Johnson, Madeleine. Study Unveils New Method for Universal Extraction and PCR Amplification of Fungal DNA. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada613354.

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Levisohn, Sharon, Mark Jackwood, and Stanley Kleven. New Approaches for Detection of Mycoplasma iowae Infection in Turkeys. United States Department of Agriculture, 1995. http://dx.doi.org/10.32747/1995.7612834.bard.

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Abstract:
Mycoplasma iowae (Mi) is a pathogenic avian mycoplasma which causes mortality in turkey embryos and as such has clinical and economic significance for the turkey breeder industry. Control of Mi infection is severely hampered by lack of adequate diagnostic tests, together with resistance to most antibiotics and resilience to environment. A markedly high degree of intra-species antigenic variation also contributes to difficulties in detection and control of infection. In this project we have designed an innovative gene-based diagnostic test based on specific amplification of the 16S rRNA gene of
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