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Journal articles on the topic 'Amygdalina'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Tuset, J. J., and M. A. T. Portilla. "Taxonomic status of Fusicoccum amygdali and Phomopsis amygdalina." Canadian Journal of Botany 67, no. 5 (1989): 1275–80. http://dx.doi.org/10.1139/b89-168.

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A comparative study was done in Spain of canker and withering of branches in almond and peach trees. Similar diseases of these fruit trees, described by several authors and attributed to Fusicoccum amygdali and Phomopsis amygdalina, suggests that these fungi are identical. Spanish isolates produced phialidic conidiogenous cells and occasionally β-conidia typical of the genus Phomopsis. A study of the type specimen of F. amygdali reveals that it also belongs in Phomopsis. Phomopsis amygdali (Del.) Tuset & Portilla comb.nov. is proposed to accommodate the fungus; Phomopsis amygdalina Canonac

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Putri, Adira Aulia, Irdat Mukaromah, Novi Dwi Pratiwi, and Galih Noor Alivian. "UTILIZATION OF AFRICAN LEAVES (VERNONIA AMYGDALINA) TO LOWER BLOOD PRESSURE IN PATIENTS WITH HYPERTENSION: A SYSTEMATIC REVIEW." International Journal of Biomedical Nursing Review 1, no. 1 (2022): 52. https://doi.org/10.20884/1.ijbnr.2022.1.1.6534.

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Introduction: Hypertension is a non-communicable disease caused by genetics, stress, and lack of physical activity. So far, no effective drugs have been found to cure high blood pressure. Vernonia amygdalina contains substances that can lower blood pressure, namely flavonoids and potassium. Purpose: The systematic review aims to assess the potential of vernonia amygdalina in lowering blood pressure in hypertensive people. Methods: Articles are obtained from electronic databases such as PubMed, ScienceDirect, and Google Scholar published from 2011 to 2021. Keywords used: ("African leaf" OR "bit

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Aulannisa, Fidya, Isnaini Nur Jannah, Erna Ayu Wulandari, Vira Cesar Oktaviani, and Eka Saputri. "Systematic Review Perbandingan Efektifitas Daun Insulin (Smallanthus sonchifolius) dan Daun Afrika (Vernonia amygdalina) dalam Penurunan Kadar Gula Darah Tikus Diabetes." Generics: Journal of Research in Pharmacy 1, no. 2 (2021): 70–78. http://dx.doi.org/10.14710/genres.v1i2.11148.

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Objective: Diabetes Melitus (DM) adalah penyakit ditandai dengan kadar glukosa darah sewaktu sama atau lebih dari 200 mg/dl, dan kadar glukosa darah puasa di atas atau sama dengan 126 mg/dl. Daun pada tanaman insulin atau yacon (Smallanthus sonchifolius) dan tanaman afrika (Vernonia amygdalina Del.) telah diketahui memiliki kemampuan menurunkan kadar glukosa darah. Penulisan systemtic review ini bertujuan untuk mengetahui perbedaan penurunan kadar glukosa darah tikus putih yang diberi perlakuan daun insulin (Smallanthus sonchifolius) dan daun afrika (Vernonia amygdalina Del).Metode: Pencarian

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Shui, Lanya, Kaisen Huo, Yan Chen, Zilin Zhang, Yanfang Li, and Jun Niu. "Integrated metabolome and transcriptome revealed the flavonoid biosynthetic pathway in developing Vernonia amygdalina leaves." PeerJ 9 (April 26, 2021): e11239. http://dx.doi.org/10.7717/peerj.11239.

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Background Vernonia amygdalina as a tropical horticultural crop has been widely used for medicinal herb, feed, and vegetable. Recently, increasing studies revealed that this species possesses multiple pharmacological properties. Notably, V. amygdalina leaves possess an abundance of flavonoids, but the specific profiles of flavonoids and the mechanisms of fl avonoid bi osynthesis in developing leaves are largely unknown. Methods The total flavonoids of V. amygdalina leaves were detected using ultraviolet spectrophotometer. The temporal flavonoid profiles of V. amygdalina leaves were analyzed by

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Nguemfo Tchankugni, Arlette, Mpoame Mbida, Jürgen Hescheler, and Filomain Nguemo. "Effect of Ethanolic Extract of Vernonia amygdalina on the Proliferation, Viability and Function of Mouse Induced Pluripotent Stem Cells and Cardiomyocytes." Plants 12, no. 5 (2023): 1108. http://dx.doi.org/10.3390/plants12051108.

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Vernonia amygdalina (V. amygdalina) leaves are commonly used in traditional medicine around the world for the treatment of a plethora disorders, including heart disease. The aim of this study was to examine and evaluate the cardiac effect of V. amygdalina leaf extracts using mouse induced pluripotent stem cells (miPSCs) and their cardiomyocytes’ (CMs) derivatives. We used a well-established stem cell culture to assess the effect of V. amygdalina extract on miPSC proliferation, EB formation and the beating activity of miPS cell-derived CMs. To study the cytotoxic effect of our extract, undiffer

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K, Igwe, Ikpeazu O, and Otuokere I. "Evaluation the Effect of Vernonia amygdalina. Del Leaves Ethanol Extract on Blood Sugar and its Synergism with Glibenclamide in Rats." Al-Anbar Journal of Veterinary Sciences 13, no. 1 (2020): 26–34. http://dx.doi.org/10.37940/ajvs.2020.13.1.4.

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Antidiabetic activity of Vernonia amygdalina and its possible synergism with glibenclamide was checked. Forty eight rats were used for the research, for hypoglycermic study of V. amygdalina alone, they were grouped into five of six rats each. Group 1 was the negative control and was administered distilled water orally. Groups 2, 3, and 4 were the treatment groups which received 100, 200 and 300 mg/kg body weight of the V. amygdalina extract respectively orally by intubation. Group 5 was the positive control group which received a known antidiabetic drug, glibenclamide. Diabetes was induced wit

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7

D.O., Ejembi,, Daniel, B.C., Adejoh, O., et al. "Comparative Study on the Effect of Aqueous Extract of Moringa Oleifera and Vernonia Amygdalina Leaves on Some Biochemical Indices of Male Wistar Rats." International Journal of Research and Scientific Innovation XII, no. V (2025): 220–26. https://doi.org/10.51244/ijrsi.2025.12060019.

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Metabolic disturbances are sometimes due to alterations in some biochemical parameters and thereby become an indicator for the assessment of metabolic syndrome. The present study evaluates the comparative effects of aqueous extract of Moringa oleifera and Vernonia amygdalina on some biochemical indices in male adult Wister rats. Thirty-two adult male Wister rats of average weight of 152 g. Rats were randomly assigned into four groups of eight each. Group one served as the control and each rat in this group received 2ml of distilled water orally and daily. Groups two and three received 2.5 g/ml

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8

Prananda, Arya Tjipta, Aminah Dalimunthe, Urip Harahap, et al. "Vernonia amygdalina protects against doxorubicin-induced hepatic and renal damage in rats: mechanistic insights." Pharmacia 70, no. 3 (2023): 825–35. http://dx.doi.org/10.3897/pharmacia.70.e112425.

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The use of the chemotherapeutic agent doxorubicin is limited due to its potential to cause signifi-cant hepatorenal damage. The present study aimed to investigate the potential hepatoprotective and nephroprotective effects of Vernonia amygdalina, a medicinal plant with known antioxidant and anti-inflammatory properties, against doxorubicin-induced toxicity in rats. Male Wistar rats were randomly divided into four groups: Control, Doxorubicin (DOX), DOX + Vernonia Amyg-dalina (DOX+VA), and Vernonia amygdalina (VA) alone. DOX and DOX+VA groups were treated with a single intraperitoneal injection

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Son, Hoang Le, Ha Nguyen Anh Tu, and Tran Van Minh. "Ameliorative Potentials of Vernonia amygdalina on Acetaminophen-induced Acute Liver Injury in Mice." Asian Journal of Biotechnology and Bioresource Technology 9, no. 2 (2023): 22–35. http://dx.doi.org/10.9734/ajb2t/2023/v9i2180.

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Aims: To investigate the ameliorative potentials of Vernonia amygdalina on acetaminophen-induced liver injury in mice. Methodology: Acetaminophen-induced acute liver injury was conducted on Swiss-albino mice weighing 25 - 30 g. Group A was maintained as a negative control (healthy liver) while group B was assigned as a positive control (damaged liver). Group C, D and E were orally administered 100 mg/kg, 200 mg/kg and 400 mg/kg of dried Vernonia amygdalina leaf extract, respectively. Meanwhile, group F, G and H were orally administered 100 mg/kg, 200 mg/kg and 400 mg/kg of fresh Vernonia

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Prananda, Arya Tjipta, Aminah Dalimunthe, Urip Harahap, et al. "Vernonia amygdalina protects against doxorubicin-induced hepatic and renal damage in rats: mechanistic insights." Pharmacia 70, no. (3) (2023): 825–35. https://doi.org/10.3897/pharmacia.70.e112425.

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The use of the chemotherapeutic agent doxorubicin is limited due to its potential to cause signifi-cant hepatorenal damage. The present study aimed to investigate the potential hepatoprotective and nephroprotective effects of Vernonia amygdalina, a medicinal plant with known antioxidant and anti-inflammatory properties, against doxorubicin-induced toxicity in rats. Male Wistar rats were randomly divided into four groups: Control, Doxorubicin (DOX), DOX + Vernonia Amyg-dalina (DOX+VA), and Vernonia amygdalina (VA) alone. DOX and DOX+VA groups were treated with a single intraperitoneal injection

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11

Oseghale, Ikalo David, Olabisi Promise Lawal, Daniel Osezuwa Ubebe, et al. "Ethnomedicinal and Phytopharmacological Aspects of Vernonia amygdalina (Bitter Leaf) Utilized as a Traditional Medicinal Herb." Asian Journal of Research in Biochemistry 14, no. 6 (2024): 41–57. http://dx.doi.org/10.9734/ajrb/2024/v14i6326.

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Vernonia amygdalina Delile, commonly known as “bitter leaf,” is a shrub in the Asteraceae family, widely seen in tropical regions of Africa. Vernonia amygdalina is found to be traditionally used in African medicine. Various parts of this plant, especially the leaves, are utilized to treat ailments such as fever, diabetes, and gastrointestinal issues. Research from multiple researchers has shown a wide range of phytochemical and bioactive compounds present in Vernonia amygdalina; examples are terpenoids, tannins, alkaloids, saponins, flavonoids, steroids, glycosides, etc., which have contribute

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12

Oklusola-Mainde, Olubukola Olayemi, and Michael Tosin Bayode. "Comparative antimicrobial study of Vernonia amygdalina Del. and Lawsonia inermis L. against microorganisms from aqueous milieu." European Journal of Biological Research 11, no. 3 (2021): 283–93. https://doi.org/10.5281/zenodo.4742538.

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Limitations have been concurrent with the use of antibiotics in chemotherapy. Hence, antimicrobial potency of aqueous and ethanol leaf extracts of <em>Vernonia amygdalina</em> and <em>Lawsonia inermis</em> on some selected multiple antibiotic resistant bacteria and fungi isolated from stream were compared. The phytochemical evaluation and antimicrobial susceptibility test of MAR bacteria and fungi was achieved via CLSI reference standard of perfloxacin (10 µg) and ketoconazole (150 mg/ml) with susceptibility index (>14.00 mm and >15.00 mm, respectively) as control for bacteria and

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13

Ajayi, Abayomi, Titilayo Ige, Nich Arawa Ude, et al. "Aqueous extract of bitter leaf Vernonia amygdalina Delile (Asterales: Asteraceae) ameliorates testosterone-induced benign prostatic hyperplasia (BPH) in Wistar rats." Brazilian Journal of Biological Sciences 4, no. 7 (2017): 45–52. http://dx.doi.org/10.21472/bjbs.040706.

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Benign prostatic hyperplasia (BPH) is an age-dependent condition involving prostate enlargement which may lead to lower urinary tract symptoms (LUTS). This study was designed to study the ameliorative effect of the aqueous extract of bitter leaf Vernonia amygdalina Delile (Asterales: Asteraceae) on testosterone-induced BPH in a rat model. Thirty adult male Wister rats were randomly divided into six groups (A to F), with BPH induced through a single subcutaneous injection of 5 mg/kg of testosterone propionate (TP) and Vernonia amygdalina administered in various doses through oral gavage for 14

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14

OSAGIE, O. A., N. B. AGUEBOR-OGIE, and G. E. ERIYAMREMU. "THE EFFECT OF METHANOLIC EXTRACT OF Vernonia amygdalina ON LIPID PEROXIDATION AND SOME ANTIOXIDANT ENZYME ACTIVITIES IN THE EARLY STAGE OF CYCASIN INDUCED TESTICULAR CARCINOGENESIS IN RATS." Nigerian Journal of Life Sciences (ISSN: 2276-7029) 4, no. 1 (2022): 175–80. http://dx.doi.org/10.52417/njls.v4i1.169.

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This study evaluated the effect of Vernonia amygdalina (V. amygdalina) on testicular lipid peroxidation, Superoxide Dismutase (SOD) and catalase (CAT) activities in the early stages of cycasin-induced testicular carcinogenesis in rats. Fifty male Wistar rats with an average weight of 175g were divided into five groups of 10 animals each. Group 1 was fed with a Normal Diet (ND) and acted as experimental control. Group 2 was fed with a Normal Diet compounded with cycasin for 6 weeks. Group 3 to Group 5 were fed with Normal Diet compounded with cycasin V. amygdalina in varied amount and duration

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15

Usunomena, U., N. Paulinus Okolie, and I. Gerald Eze. "Inhibitory Effect of Vernonia amygdalina on Dimethylnitrosamine (DMN)-induced Liver Fibrosis in Rats." International Journal of Clinical Pharmacology & Toxicology (IJCPT) 4, no. 4 (2015): 179–84. https://doi.org/10.19070/2167-910X-1500030.

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In this study, the protective effect of Vernonia amygdalina ethanolic leaf extract against hepatic fibrosis induced by repeated intermittent administration of Dimethylnitrosamine (DMN) was investigated in rats. A total of 48 rats divided into 4 groups were used. Group 1 served as control, Group 2 received 200mg/kg Vernonia amygdalina only for 14days, Group 3 received 200mg/kg Vernonia amygdalina for 14 days followed by intraperitoneal administration of 10mg/kg DMN on first three days of each week for 2 weeks, while Group 4 received intraperitoneal administration of 10mg/kg

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16

Harefa, Herman Syukur, Poppy Anjelisa Zaitun Hasibuan, and Urip Harahap. "Cytotoxic and Apoptotic Activities of Vernonia amygdalina Extract in HepG2 Cell Line." Indonesian Journal of Pharmaceutical and Clinical Research 5, no. 2 (2022): 24–29. http://dx.doi.org/10.32734/idjpcr.v5i2.6350.

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Liver cancer is a malignant tumor originating from the development of chronic hepatitis or cirrhosis and is responsible for damage to the shape and function of the liver. The loss of the ability of conventional chemotherapy to inhibit the growth of cancer cells is a major focus in the world. Natural ingredients are the solution to this problem, for example the use of Vernonia amygdalina leaves. Vernonia amygdalina contains flavonoids, cardiac glycosides, and steroids/triterpenoids which are reported to have anticancer properties. This study aims to examined the activity of these plants as anti

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17

Afuye, O. O., and S. O. Omotayo. "Evaluation of In vitro Anti-Diabetic Properties of Biosynthesized Magnesium Oxide Nanoparticles from Vernonia amygdalina (Bitter Leaf) Aqueous Leaf Extract." European Journal of Medicinal Plants 35, no. 1 (2024): 45–55. http://dx.doi.org/10.9734/ejmp/2024/v35i11178.

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Introduction: Vernonia amygdalina is a common shrub that is widely used and extracts from them have been traditionally used as remedies for treating diabetes mellitus in various parts of the world. The use of V. amygdalina to synthesize MgO nanoparticles has been used for various biomedical applications and it is compatible with anti-diabetic studies. This research investigates the in vitro anti-diabetic potentials of biosynthesized from aqueous V. amygdalina leaf extract. Methodology: Aqueous extract of V. amygdalina-MgO nanoparticles were characterized using Fourier Transform Infrared, X-ray

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Sukarjati, Sukarjati, and Ganda Adi Nugroho. "Potensi Ekstrak Daun Afrika (Vernonia amygdalina), Daun Pepaya (Carica papaya L) Serta Kombinasi Kedua Ekstrak Terhadap Jumlah Folikel Primer, Sekunder dan Tersier Pada Mencit (Mus musculus)." Wahana 73, no. 2 (2021): 39–57. http://dx.doi.org/10.36456/wahana.v73i2.4513.

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African leaf (Vernonia amygdalina) and papaya leaf (Carica papaya L) are plants that contain secondary metabolites and are thought to have antifertility effects. V amygdalina and C papaya L leaves contain flavonoids, saponins, tannins, and alkaloids. The purpose of this study was to prove that V amygdalina leaf extract, C papaya L leaf and the combination of the two extracts could reduce the number of primary, secondary and tertiary follicles. This study used 44 female mice. Extraction was carried out by maceration . The doses of V amygdalina leaf extract and C papaya L leaf extract used were

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C. Oladele, Funmilola. "Therapeutic Efficacy of Vernonia amygdalina and Persea americana Extracts in Mitigating Endothelial Dysfunction, Oxidative Stress, and Cardiac Biomarkers in Lipopolysaccharide-Induced Hypertension during Pregnancy." Journal of Obstetrics Gynecology and Reproductive Sciences 9, no. 3 (2025): 01–10. https://doi.org/10.31579/2578-8965/264.

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Objective: This study investigates the therapeutic efficacy of Vernonia amygdalina and Persea americana extracts in mitigating lipopolysaccharide-induced hypertension during pregnancy, focusing on endothelial dysfunction, oxidative stress, and cardiac biomarkers in albino rats. Materials and Methods: V. amygdalina and P. americana samples were collected, dried, powdered, and extracted using ethanol. Fifty-four pregnant Wistar rats were divided into nine groups, including a control group, an LPS-only group, and groups treated with various dosages of V. amygdalina and P. americana extracts. The

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Fitriani, Nyayu, Kamalia Layal, and Kamila Kamila. "Aktivitas Antidiabetes Kombinasi Ekstrak Etanol Daun Andrographis Paniculata dan Vernonia Amygdalina." Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan 7, no. 2 (2017): 104. http://dx.doi.org/10.32502/sm.v7i2.1371.

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Diabetes mellitus merupakan sekelompok penyakit metabolik yang ditandai dengan hiperglikemia kronik yang diakibatkan oleh defek pada sekresi insulin, aksi insulin atau keduanya. Daun Andrographis paniculata dan Vernonia amygdalina merupakan tanaman yang dapat digunakan sebagai pengendali kadar gula dalam darah. Penelitian ini bertujuan untuk mengetahui efektivitas kombinasi ekstrak kedua daun dibandingkan dengan acarbose dalam menurunkan kadar gula darah postprandial tikus diabetes. Penelitian ini adalah penelitian eksperimental, dengan pre dan post test control group design. Tikus diinduksi d

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Emiri, U. N., and E. B. Enaregha. "Phytochemical screening and antifungal potency of Vernonia amygdalina (bitter leaf) extract against post harvest mycodeterioration of tomato (Lycopersicum esculentum)." Brazilian Journal of Biological Sciences 7, no. 17 (2020): 327–37. http://dx.doi.org/10.21472/bjbs(2020)071708.

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The study investigated fungi associated with post harvest tomato fruits sold in the open market in Port Harcourt Metropolis. The antifungal activity (bitter leaf) extracts against spoilage was studied using well-in-agar diffusion method. Results showed that mean percentage incidence of fungi isolated from tomato fruits were Rhizopus stolonifer (56%), Aspergillus niger (62%) and Altermaria altermata (35%). Aqueous and ethanolic extracts of Vernonia amygdalina at different concentrations (20%, 40%, and 60%) (w/v) were used against fungi isolates, while water and ketoconzole (0.5 mg/mL) served as

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Hsu, Chia-Fang, Fu-An Yang, Shih-Chuan Liu, et al. "Protective Role of Vernonia Amygdalina Leaf Aqueous Extract Against Neomycin-Induced Hair Cell Damage in Transgenic Zebrafish." Current Topics in Nutraceutical Research 18, no. 4 (2020): 366–72. http://dx.doi.org/10.37290/ctnr2641-452x.18:366-372.

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Aminoglycoside treatment increases the loss of hair cells in the inner ear. Once the hair cells are lost, they are unable to regenerate spontaneously, and the resulting hearing loss is profound and irreversible in humans. The aqueous extract from the leaves of Vernonia amygdalina has been reported to have antioxidant properties. In this study, we evaluated whether the aqueous extracts of Vernonia amygdalina leaf could protect hair cells from aminoglycoside-induced damage using a transgenic zebrafish line. Our results showed that the EC<sub>50</sub> of 1,1-Diphenyl-2 picrylhydrazyl radical scav

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Awwaliah, Mardhatillah, Mukhriani Mukhriani, Nur Asma, and Muhammad Ikhlas Arsul. "Korelasi Kadar Fenol dan Flavonoid terhadap Indeks Aktivitas Antioksidan Ekstrak Batang Vernonia amygdalina." Jurnal Sains dan Kesehatan 5, no. 5 (2023): 652–58. http://dx.doi.org/10.25026/jsk.v5i5.1959.

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Bitter leaf (in Africa) is the most widely cultivated species of the genus Vernonia which is the most prominent in the family Asteraceae that has been studied in Africa. African leaves have been widely used for traditional medicine and/or treating various human diseases. This study aimed to determine the bioactive compounds that correlate to the antioxidant activity of V. amygdalina stem. Extraction of V. amygdalina stem was carried out by reflux method. Determination of total phenol and flavonoid content was done spectroscopically. Antioxidant activity was measured based on antioxidant activi

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Davies, Koofreh, Emmanuel Olorunsola, Nathaniel Udokang, Kubiat Umana, Mfonobong Alozie, and Innocent Edagha. "Ameliorative Effects of Vernonia amygdalina and Moringa oleifera Extracts on Cognitive Impairment in Diabetic Wistar Rats." NIgerian Journal of Neuroscience 13, no. 2 (2022): 67–76. http://dx.doi.org/10.47081/njn2022.13.2/004.

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This study investigated the ameliorative effects of Vernonia amygdalina and Moringa oleifera on cogni-tive impairment in alloxan-induced diabetes mellitus in male Wistar rats. The animals were allotted into eight groups of five. Group 1 were not induced nor treated. Diabetes was induced with alloxan (135 mg/kg body weight) in groups 2-8. Group 2 which served as diabetic control received distilled water (10 mL/kg). Groups 3-8 were administered ethanol extracts of V. amygdalina (200 mg), M. oleifera (500 mg), V. amygdalina (400 mg), M. oleifera (1,500 mg), V. amygdalina (300 mg) + M. oleifera (1

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Rotimi, Damilare Emmanuel, Goodnews Mavoghenegbero Ben-Goru, Ikponmwosa Owen Evbuomwan, et al. "Zingiber officinale and Vernonia amygdalina Infusions Improve Redox Status in Rat Brain." Evidence-Based Complementary and Alternative Medicine 2022 (September 26, 2022): 1–9. http://dx.doi.org/10.1155/2022/9470178.

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The study investigated the effects of Zingiber officinale root and Vernonia amygdalina leaf on the brain redox status of Wistar rats. Twenty-four (24) rats weighing 160 ± 20 g were randomly assigned into four (4) groups, each with six (6) rats. Animals in Group 1 (control) were orally administered distilled water (1 mL), while the test groups were orally administered 5 mg/mL of either Z. officinale, V. amygdalina infusion, or a combination of both, respectively, for 7 days. The rats were sacrificed at the end of treatments and blood and tissue were harvested and prepared for biochemical assays

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Ahamefula Sunday Ezekwe, Karibo Amakiri Okari, Peter Gift Wokocha, Mike Tochi Achor, and Boma Ngo Fubara. "Evaluating alloxan-induced diabetic rats." International Journal of Science and Research Archive 13, no. 2 (2024): 3544–52. https://doi.org/10.30574/ijsra.2024.13.2.2499.

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The increasing incidence of diabetes and the adverse effects of chemical medications underscore the importance of exploring alternative non-pharmacological treatments. Vernonia amygdalina, a widely utilized medicinal herb, shows promising therapeutic potential. This study investigated the impact of aqueous leaf extracts of Vernonia amygdalina on various biochemical parameters in alloxan-induced diabetic rats. Diabetes was induced in male Wistar rats through intraperitoneal injection of alloxan (150 mg/kg). The rats were then randomly divided into four groups: Group 1 (normal control), Group 2

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Usunobun, Usunomena, and Okolie Ngozi. "Phytochemical analysis and proximate composition of Vernonia amygdalina." International Journal of Scientific World 4, no. 1 (2016): 11. http://dx.doi.org/10.14419/ijsw.v4i1.5845.

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<p><strong>Background:</strong> <em>Vernonia amygdalina</em> is used to prepare dishes as well as a multi-purpose fodder tree with high biomass yield. This study was conducted to determine phytochemicals and proximate composition of <em>Vernonia amygdalina</em> leaves.</p><p><strong>Methods:</strong> Evaluation of <em>Vernonia amygdalina</em> for phytochemicals and proximate composition were conducted using standard methods.</p><p><strong>Results:</strong> Result showed that <em>Vernonia

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Chainanta, Jiratchaya, Kittiporn Yakajay, Chanakarn Chinda, et al. "Vernonia amygdalina Extract Loaded Microspheres for Controlling Phytophthora palmivora." Sustainability 15, no. 14 (2023): 10842. http://dx.doi.org/10.3390/su151410842.

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The adverse effects of modern fungicide consumption have caused many issues in the agroecosystem. Hence, under sustainable agriculture concepts, it is important to research alternatives to the currently used fungicide. The use of secondary metabolite-containing herbal extracts for treating plant diseases has become the latest trend in sustainable and green agriculture. However, the poor solubility and volatile nature of many compounds cause practical issues when using them in the field. Hence, bioactive compound delivery through nano- or micro-particles has become a successful technique to imp

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Abdulrahman, A., M. G. Garba, S. Gaddafi, and A. Yusuf. "RESPONSE OF YANKASA RAMS TO VARIOUS INCLUSION LEVELS OF PROPAGATED BITTER LEAF (Vernonia amygdalina) ON PERFORMANCE AND RUMEN ECOLOGY." FUDMA Journal of Animal Production and Environmental Science 1, no. 1 (2025): 46–51. https://doi.org/10.33003/japes.2025.v1i1.46-51.

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The experiment evaluated the response of Yankasa rams fed graded levels of propagated Bitter Leaf (Vernonia amygdalina) on growth performance, nutrient digestibility, rumen ecology, and blood profile. Twenty (20) rams were randomly allocated into four dietary treatments consisting of 0%, 5%, 10%, and 15% inclusion levels of dry bitter leaf. Growth performance, nutrient digestibility trail and rumen fluid were collected and analyzed accordingly. Data obtained were analyzed using statistical analysis system (SAS,2002). Growth performance results showed that T3(15%) had an outstanding (P<0.05)

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Boadu, A., S. Singh, R. Karpoormath, and M. Nlooto. "REVIEW ON ETHNOMEDICINAL USES, PHYTOCHEMICAL CONSTITUENTS AND PHARMACOLOGICAL EVIDENCE ON LEAF EXTRACT OF PERSEA AMERICANA AND VERNONIA AMYGDALINA OF THE AFRICAN CONTINENT - A REVIEW." INDIAN DRUGS 56, no. 01 (2019): 7–24. http://dx.doi.org/10.53879/id.56.01.11623.

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People on the African continent frequently consume Persea americana and Vernonia amygdalina for food and medicinal purposes. The review is an effort to compile ethnomedicinal, phytochemical and pharmacological knowledge is the above two plants from the year 2000 till now. A search was carried out using a combination of several keywords : Persea americana, Vermonia amygdalina, traditional medicine, ethnomedicine, avocado, bitter leaf and integrated approaches. Published papers in English language were retrieved from the online bibliographical databases: Web of Science, PubMed, Google Scholar, S

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Awwaliah, Mardhatillah, Mukhriani Mukhriani, Nur Asma, and Muhammad Ikhlas Arsul. "Korelasi Kadar Fenol dan Flavonoid terhadap Indeks Aktivitas Antioksidan Ekstrak Batang Vernonia amygdalina." Jurnal Sains dan Kesehatan 5, no. 5 (2024): 652–58. https://doi.org/10.30872/jsk.v5i5.561.

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Daun afrika merupakan spesies yang paling banyak dibudidayakan dari genus Vernonia yang paling menonjol dalam famili Asteraceae yang telah dipelajari di Afrika. Daun afrika telah banyak digunakan untuk pengobatan tradisional dan/atau mengobati berbagai penyakit pada manusia. Tujuan dari penelitian ini adalah untuk mengetahui senyawa bioaktif yang berkorelasi terhadap aktivitas antioksidan dari batang V. amygdalina. Ekstraksi batang V. amygdalina dilakukan dengan metode refluks. Penentuan kadar fenol dan flavonoid total dilakukan secara spektroskopi. Aktivitas antioksidan diukur berdasarkan ind

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Chijindu, Pass C., Onyeka B. Onyeukwu, and Udomah Ogheneoruese. "Evaluation of Nutritional, Phytochemicals and Antioxidant Capacity of Telfairia Occidentalis F. and Vernonia Amygdalina Delile Leaves." Nigerian Journal of Biochemistry and Molecular Biology 39, no. 3 (2024): 170–77. https://doi.org/10.4314/njbmb.v39i3.8.

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This study assessed the nutritional composition, phytochemical constituents, and antioxidant activities of Telfairia occidentalis and Vernonia amygdalina leaves. Standard analytical methods were employed to evaluate the powdered and aqueous extracts of both plants. Findings indicated that T. occidentalis exhibited higher levels of moisture (11.43%), crude fiber (9.11%), protein (8.19%), and crude lipid (3.67%) compared to V. amygdalina. No significant difference was observed in total ash content between the two species. Qualitative phytochemical analysis identified the presence of saponins, ca

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Ilechukwu, C. C., C. O. Ezenwelu, J. C. Ifemeje, J. N. Ilechukwu, and I. H. Iheukwumere. "Comparative Assessment of the In vitro Antioxidant Activity and Phytochemical Analysis of Vernonia amygdalina Leaf and Ocimum gratissimum Leaf." IPS Journal of Drug Discovery Research and Reviews 3, no. 1 (2025): 38–43. https://doi.org/10.54117/ijddrr.v3i2.33.

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Vernonia amygdalina and Ocimum gratissimum are a major part of the diet in many Nigerian families due to their wide culinary applications and appeal. This study, therefore, compared the in-vitro antioxidant activity and phytochemical content of the extracts of these two plants. The methanol extracts of freshly plucked leaves of Vernonia amygdalina and Ocimum gratissimum were obtained and extracted using standard procedures. The phytochemical composition and in-vitro antioxidant parameters (nitric oxide and hydrogen peroxide) were assessed. The results of the phytochemical screening of methanol

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Ikbal, Abu Md Ashif, Amlanjyoti Rajkhowa, P. Chinglemba Singh, Paromita Dutta Choudhury, and Ram Kumar Sahu. "Assessment of Phytochemical and Anthelmintic Activity of Some Selected Ethnomedicinal Plants from Barak Valley Region of Assam." Biomedical and Pharmacology Journal 13, no. 4 (2020): 1825–31. http://dx.doi.org/10.13005/bpj/2057.

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Since ancient times it has been observed that the ethnomedicinal knowledge is backbone of rural healthcare. The traditional healers of Barak Valley region of Assam used traditional medicine for the treatment of various diseases including helminths infection. Hence the current study was planned to explore the traditional medicines namely Justicia adhatoda, Vernonia amygdalina, Mikania micrantha and Momordica charantia used as anthelmintic activity by the local people of Barak Valley region of Assam. The decoction of leaves of Justicia adhatoda, Vernonia amygdalina, Mikania micrantha and Momordi

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Ikbal, Abu Md Ashif, Amlanjyoti Rajkhowa, P. Chinglemba Singh, Paromita Dutta Choudhury, and Ram Kumar Sahu. "Assessment of Phytochemical and Anthelmintic Activity of Some Selected Ethnomedicinal Plants from Barak Valley Region of Assam." Biomedical and Pharmacology Journal 13, no. 4 (2020): 1825–31. http://dx.doi.org/10.13005/bpj/2057.

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Since ancient times it has been observed that the ethnomedicinal knowledge is backbone of rural healthcare. The traditional healers of Barak Valley region of Assam used traditional medicine for the treatment of various diseases including helminths infection. Hence the current study was planned to explore the traditional medicines namely Justicia adhatoda, Vernonia amygdalina, Mikania micrantha and Momordica charantia used as anthelmintic activity by the local people of Barak Valley region of Assam. The decoction of leaves of Justicia adhatoda, Vernonia amygdalina, Mikania micrantha and Momordi

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Maulana, Maulana Zulkarnain Imansyah, and Atriana Zain. "Uji Efektivitas Sediaan Krim Ekstrak Etanol Daun Afrika (Vernonia amygdalina Del.) Terhadap Bakteri Propionibacterium acnes." Jurnal Kesehatan Yamasi Makassar 7, no. 1 (2023): 81–88. http://dx.doi.org/10.59060/jurkes.v7i1.239.

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Daun Afrika (Vernonia amygdalina Del.) atau yang dulu disebut “Daun Pahit” merupakan salah satu varietas tanaman yang digunakan sebagai obat herbal. Daun afrika berkhasiat sebagai antibakteri, antijamur, antialergi, antioksidan, analgesik dan antiinflamasi. Daun afrika mengandung metabolit sekunder seperti flavonoid, saponin, tanin, steroid, terpenoid. Penelitian ini bertujuan untukmengetahui efektivitas sediaan krim ekstrak etanol daun Afrika (Vernonia amygdalina Del.) terhadap bakteri Propionibacterium acnes. Penelitian ini dilakukan dengan metode Eksperimental Laboratorium. Di buat krim eks

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Anifowose, Oluwagbenga, Bitrus W. Tukura, and Obaje D. Opaluwa. "Detoxification Efficiency of Ethanolic Leaf Extracts of Moringa oleifera and Vernonia amygdalina on Aflatoxin B1 in Rice and Maize." International Journal of Scientific Research in Chemical Sciences 12, no. 2 (2025): 1–6. https://doi.org/10.26438/ijsrcs.v12i2.187.

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The prevalence of aflatoxin B1 in stored agricultural produce and their subsequent effect on food safety has stepped up researches to identify novel phytoremediation techniques. This research evaluates the potency of phytochemical remediation on aflatoxin B1 (AFB1) in stored rice and maize using ethanolic leaf extracts of Moringa oleifera and Vernonia amygdalina. HPLC-UV/Vis spectroscopy was employed in the determination of the detoxification levels of the AFB1 in the samples. Phytochemical constituents in the plant extracts were quantified using standard methods. Phytochemical concentrations

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Omeodu, SI, and PO Uahomo. "ANTI-HYPERGLYCEMIC AND HEPATOPROTECTIVE PROPERTIES OF COMBINED AQUEOUS LEAF EXTRACT OF Vernonia amygdalina AND Moringa oleifera IN EXPERIMENTALLY INDUCED DIABETIC RAT MODEL." International Journal of Recent Research in Life Sciences (IJRRLS) 10, no. 1 (2023): 1–7. https://doi.org/10.5281/zenodo.7496485.

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<strong>Abstract:</strong> This study was carried out to investigate the anti-hyperglycemic and hepato-protective properties of combined leaf extracts of <em>Vernonia amygdalina</em> and <em>Moringa oleifera</em> in alloxan-induced diabetic Wistar rats. The study design involved 25 rats weighing 140 to 2100g which were randomly divided into 5 groups of 5 rats each. Group 1 received distilled water and feed; group 2 received no treatment; group 3 received 4% extract combination of <em>V. amygdalina</em> and <em>M. oleifera</em>; group 4 received 8% extract combination of <em>V. amygdalina</em>

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Bbosa, Godfrey S., Robert Lubajo, Aloysius M. Lubega, Gordon Odia, and John Katerega. "Effects of leaf extracts of Vernonia amygdalina on the force and rate of contractility of an isolated mammalian heart." International Journal of Basic & Clinical Pharmacology 8, no. 11 (2019): 2389. http://dx.doi.org/10.18203/2319-2003.ijbcp20194773.

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Background: Vernonia amygdalina is a common medicinal plant that is widely used by local communities and traditional herbalists in central Uganda in management of various conditions including hypertension that occurs as a result of changes in heart contractility. However, there is limited scientific information of V. amygdalina effects on the force and rate of contractility of the heart. The study evaluated the inotropic and chronotropic effect of methanol, aqueous, ether and total crude leaf extracts of V. amygdalina on isolated perfused rabbit heart.Methods: An experimental laboratory based

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EHI-Omosun, MB, and GI EZE. "Effects of Aqueous Leaf Extract of Vernonia amygdalina on High-Fat Diet-Induced Injury in the Heart and Aorta of the Adult Wistar Rat." Journal of Phytopharmacology 12, no. 2 (2023): 93–99. http://dx.doi.org/10.31254/phyto.2023.12205.

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The aim of this study was to investigate the effects of aqueous leaf extract of Vernonia amygdalina in Wistar rats fed with high-fat diet. 30 adult Wistar rats weighing between 250g and 280g were randomly assigned into 5 groups of 6 rats per group. Group A rats were placed on rat food and water only. Group B rats received 1000mg/kg body weight / day (BWT/D) of margarine. Group C rats received 300mg/kg BWT/D of V. amygdalina. Group D rats received 1000mg/kg BWT/D of margarine and 150mg/kg BWT/D of V. amygdalina. Group E rats received 1000mg/kg BWT/D of margarine and 300mg/kg BWT/D of V. amygdal

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Elizabeth Obioma Nweke, Cosmas Chiedozie Ofoegbu, Melford Uche Elendu, Chijioke Ikejiaku Ugboaja, and Eziamaka Okechukwu Daniel. "Evaluation of the effect of ethanol leaf extract of Vernonia amygdalina on the Testicle of Diabetic Wistar Rats." GSC Biological and Pharmaceutical Sciences 20, no. 2 (2022): 220–25. http://dx.doi.org/10.30574/gscbps.2022.20.2.0300.

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The aim of this study was to evaluate the effect of ethanol leaf extract of V. amygdalina on the testicle of alloxan induced diabetic wistar rats. Freshly harvested leaves of V. amygdalina was washed with clean tap water and subsequently dried at room temperature prior to being ground to fine powder. Twenty (20) adult male wistar rats were divided into four (4) groups of five (5) rats per group. · Group I was the normal control and was fed rat chow and water · Group II was induced diabetes without treatment, while · Groups III and IV were diabetic rats administered with 100 mg/kg and 200 mg/kg

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Zhang, Meng, Tetsukazu Yahara, Shuichiro Tagane, et al. "Cryptocarya kaengkrachanensis, a new species of Lauraceae from Kaeng Krachan National Park, southwest Thailand." PhytoKeys 140 (March 4, 2020): 139–57. http://dx.doi.org/10.3897/phytokeys.140.34574.

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A new species of Lauraceae, Cryptocarya kaengkrachanensis M.Z.Zhang, Yahara &amp; Tagane, from Kaeng Krachan National Park, Phetchaburi Province, southwestern Thailand, is described and illustrated. This species is morphologically most similar to C. amygdalina in that its leaves are pinnately veined, leathery, and apparently glabrous (but microscopically hairy) abaxially, twigs are yellowish brown hairy, and fruits are 1.36 to 1.85 times longer than width. However, C. kaengkrachanensis is distinguished from C. amygdalina in having the leaves of ovate and elliptic (vs. oblong-lanceolate) wi

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Usunobun, Usunomena, and Gabriel Anyanwu. "Dimethylnitrosamine (DMN) pre-treated rats and protective effect of Vernonia amygdalina post-treatment on liver function." International Journal of Pharmacology and Toxicology 4, no. 1 (2016): 74. http://dx.doi.org/10.14419/ijpt.v4i1.6065.

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Background: Liver disease and toxicity is common, especially with many drug treatments. The effect of Vernonia amygdalina ethanolic leaf extract post-treatment on rats pre-treated with dimethylnitrosamine (DMN) was evaluated.Methods: Male wistar rats were orally administered DMN (single dose of 25 mg/kg) on first day and thereafter post-treated with 100 and 200mg/kg ethanolic leaf extract of Vernonia amygdalina for seven days. Analysis of serum concentrations of albumin, total protein, total bilirubin and glucose were carried out.Results: Administration of DMN alone to rats significantly incre

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Magaji, Auwal, Zinat Mahmud, and Aminu Mustafa. "Phytochemical Analysis and Assessment of Antibacterial Efficacy of Vernonia amygdalina (Bitter Leaf) against Some Selected Clinical Bacterial Isolates." UMYU Journal of Microbiology Research (UJMR) 8, no. 2 (2023): 174–80. http://dx.doi.org/10.47430/ujmr.2382.020.

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Vernonia amygdalina is a plant known to contain substances with reported antimicrobial properties against various microorganisms. This study therefore, aimed at assessing the antibacterial properties of Vernonia amygdalina extract against some clinical bacterial isolates. The bacterial isolates were obtained from General hospital Azare, and the Vernonia amygdalina leaves were purchased at Azare central market. Various compounds, including saponins, glycosides, tannins, flavonoids, steroids, phenolic compounds, and alkaloids, were identified in the plant extract via phytochemical screening. Dif

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45

Zhang, Meng, Tetsukazu Yahara, Shuichiro Tagane, et al. "Cryptocarya kaengkrachanensis, a new species of Lauraceae from Kaeng Krachan National Park, southwest Thailand." PhytoKeys 140 (March 4, 2020): 139–57. https://doi.org/10.3897/phytokeys.140.34574.

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A new species of Lauraceae, Cryptocarya kaengkrachanensis M.Z.Zhang, Yahara & Tagane, from Kaeng Krachan National Park, Phetchaburi Province, southwestern Thailand, is described and illustrated. This species is morphologically most similar to C. amygdalina in that its leaves are pinnately veined, leathery, and apparently glabrous (but microscopically hairy) abaxially, twigs are yellowish brown hairy, and fruits are 1.36 to 1.85 times longer than width. However, C. kaengkrachanensis is distinguished from C. amygdalina in having the leaves of ovate and elliptic (vs. oblong-lanceolate) with l

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Uthman H. "Kinetic Studies on the Inhibition Potential of Bitter Leaf (Vernonia Amygdalin) in the Management of Diabetes." GSC Advanced Research and Reviews 21, no. 3 (2024): 184–97. https://doi.org/10.30574/gscarr.2024.21.3.0483.

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The aim of this study was to investigate the inhibition potential of extracts from Vernonia amygdalina on α-amylase and α-glucosidase activity, and its useful mechanisms in the treatment of diabetes specifically Type 2. The searchlight is beamed on the potential of the plant extract to inhibit the activity of α-amylase and thereby determining its mechanism or mode on inhibition as well as its IC50 value. The inhibition of alpha-amylase and alpha-glucosidase enzymes is a key strategy in managing diabetes. Vernonia amygdalina is a natural plant extract that has been used traditionally to manage

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Tedla, Abebe, Tesfaye Sharew, Minbale Gashu, and Belete Tewabe. "Comparative Study of the Phytochemical Constituents and Antibacterial Activity of Vernonia amygdalina and Moringa oleifera Crude Extracts." BERHAN INTERNATIONAL RESEARCH JOURNAL OF SCIENCE AND HUMANITIES 8, no. 1 (2024): 62–81. https://doi.org/10.61593/dbu.birjsh.01.08.04.

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Vernonia amygdalina Amharic vernacular name “Grawa” and Moringa oleifera Amharic vernacular name “Shiferaw”, are the most common traditional medicinal plants used in Ethiopia. The parts of these plants such as stem bark, leaves and flowers showed varieties of medicinal properties and cure various human and animal diseases and ailments. The purpose of this study was to investigate the antibacterial activity and the phytochemical constituents of the crude extracts of Vernonia amygdalina and Moringa oleifera. Maceration technique was employed to obtain crude extracts from the various parts of the

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ZAHRA, IKLILA. "UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN AFRIKA (Vernonia amygdalina Del.) TERHADAP BAKTERI Escherichia coli ATCC 25922 SECARA In Vitro." MEDFARM: Jurnal Farmasi dan Kesehatan 10, no. 1 (2021): 28–34. http://dx.doi.org/10.48191/medfarm.v10i1.52.

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Obat tradisional merupakan bahan atau ramuan berupa tumbuhan, bahan hewan atau bahan lainnya. Salah satu contoh obat tradisional adalah Tanaman Daun Afrika (Vernonia amygdalina Del.). Daun Afrika (Vernonia amygdalina Del.) memiliki beberapa kandungan kimia seperti Flavanoid, alkaloid, tanin dan kandungan kimia lainnya yang diyakini berkhasiat untuk pengobatan beberapa penyakit seperti diabetes, hipertensi, asam urat dan antibakteri. Tujuan: Penelitian ini bertujuan untuk mengetahui potensi antibakteri pada Escherichia coli dengan menggunakan metode difusi cakram. Hasil Penelitian : Zona hambat

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M. Muhammad, E.D. Putra, H. Cintya, and D. Satria. "THE EFFECT OF SOLVENT TOWARDS ANTIOXIDANT ACTIVITY OF Vernonia amygdalina Delile LEAVES." RASAYAN Journal of Chemistry 16, no. 02 (2023): 760–65. http://dx.doi.org/10.31788/rjc.2023.1628059.

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Antioxidants guard against reactive oxygen free radicals. Antioxidants neutralize free radicals by adding electrons to them, preventing bodily harm. African leaves (Vernonia amygdalina Delile.) contain an antioxidant. African leaves are the leaves of a thousand diseases because they have pharmacological effects on various diseases. African leaves contain steroids/triterpenoids, glycosides, saponins, tannins, and flavonoids. This study examined Vernonia amygdalina Delile. leaf combination ethanol extract antioxidant properties. The extracts were prepared with the reflux method using methanol, b

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Raimi, C. O., W. A. Oyelade, and A. O. Iyanda. "Histopathological effect of aqueous bitter leaf extract (Vernonia amygdalina) on acetaminophen-induced liver damage in albino rat (Rattus norvegicus)." Nigerian Journal of Animal Production 47, no. 4 (2020): 24–31. http://dx.doi.org/10.51791/njap.v47i4.95.

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Liver diseases are a worldwide problem. Medicinal plants are being increasingly utilized to treat a wide variety of diseases, liver disorder inclusive. The effect of aqueous leaf extracts of Vernonia amygdalina on acetaminophen-induced liver damage via the assessment of the histopathological examination was examined. Five groups of albino rats were used (n = 5). Animals in group 1 were fed normal laboratory pellet and water ad libitum (Control); those in group 2 received 3000mg/kg of acetaminophen alone. Groups 3, 4 and 5 received 3000mg/kg of acetaminophen and in addition 50mg/kg Vernonia amy

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